Publications

intratumoral blood flow in uterine myoma correlated with a lower tumor size and volume, but not correlated with cell proliferation or angiogenesis.	to investigate the correlation of intratumoral blood flow in uterine myoma with cell proliferation, angiogenesis, tumor size, and tumor volume.	1996	8649683
pregnancy outcome at age 40 and older.	to examine pregnancy outcome among women age 40 years and older.	1996	8649698
ventricular outflow tract reconstructions with cryopreserved cardiac valve homografts. a single surgeon's 10-year experience.	from january 1, 1985 through december 31, 1994, one surgeon implanted cryopreserved valved homografts into 149 patients--65 since december 1988. this latter series (ii) was accomplished in a single hospital, facilitating patient follow-up with biannual echocardiograms. analysis of these 65 patients is the primary focus of this report; the indications and early surgical results for the two parts of the series (i and ii) are compared to assess the evolution of a single surgeon's use of homografts ...	1996	8651745
motor changes in presymptomatic huntington disease gene carriers.	to determine whether changes in motor function and reaction time are present in presymptomatic individuals carrying the huntington disease (hd) allele.	1996	8660148
anti-cd4 monoclonal antibodies suppress murine collagen-induced arthritis only at the time of primary immunisation.	we have examined the ability of a mixture of two anti-cd4 mabs to protect against collagen-induced arthritis. anti-cd4 mabs, administered around the time of primary immunisation with type ii collagen in adjuvant, reduced the subsequent incidence of arthritis from 67 to 16% (p < 0.01 by fisher exact test). however, anti-cd4 treatment 3 weeks after the primary immunisation did not significantly affect the incidence of arthritis. this result extends earlier findings concerning the lack of efficacy ...	1996	8660829
glutamine suppresses pge2 synthesis and breast cancer growth.	reduced natural killer (nk) activity found in tumor-bearing hosts has been associated with high levels of prostaglandin e2 (pge2) produced by monocytes in vitro. we have previously demonstrated a dependence of nk cell activity on glutamine (gln) levels in vitro and in vivo. further, glutathione (gsh) is antagonistic to pge2 synthesis. we hypothesized that gln, through increased gsh production, leads to decreased pge2 synthesis and upregulation of nk cytotoxic activity. to test this, we examined ...	1996	8661213
low-molecular-weight heparin versus warfarin for prevention of recurrent venous thromboembolism: a randomized trial.	a group of 105 consecutive patients with venographically proved major acute deep vein thrombosis (dvt) were randomized in an open prospective study to evaluate the comparative efficacy and safety of a fixed dose of subcutaneous low-molecular-weight heparin (lmwh) and warfarin for the prevention of recurrent venous thromboembolism. four patients developed venographically proved recurrent dvt during the 3 months of treatment: three in the lmwh group and one in the warfarin group. nonfatal pulmonar ...	1996	8661630
environmental contaminants and cholinesterase activity in the brain of fisher (martes pennanti) harvested in northern wisconsin.		1996	8661874
inhibition of cellular processing of surfactant protein c by drugs affecting intracellular ph gradients.	surfactant protein c (sp-c) is a hydrophobic protein synthesized and secreted exclusively by alveolar type ii cells through proteolysis of a 21-kda propeptide (sp-c21) to produce the 3.7-kda surface active form. previous studies from this laboratory have demonstrated that early processing of prosp-c involves extensive intracellular proteolysis of the cooh terminus of prosp-c21 in subcellular compartments, which include the acidic type ii cell-specific subcellular organelle, the lamellar body. (b ...	1996	8662952
glycolipid-independent sorting of a secretory glycoprotein to the apical surface of polarized epithelial cells.	proteins attached to the membrane by a glycosylphosphatidylinositol (gpi)-anchor cluster together with glycolipids in detergent-insoluble complexes at the site of sorting in the trans-golgi network. this process has been shown to be critical for the targeting of these proteins to the apical cell surface in polarized epithelial cells. we show in this study that gp80 (clusterin), an apically secreted glycoprotein, is not included in detergent-insoluble complexes in madin-darby canine kidney cells. ...	1996	8663455
selective uptake of viral and monocrystalline particles delivered intra-arterially to experimental brain neoplasms.	in this study we investigated the intra-arterial delivery of viral and nonviral particles to experimental brain tumors. a herpes simplex virus (hsv) vector and monocrystalline iron oxide nanoparticles (mion) were injected into the internal carotid artery of fisher 344 rats harboring intracerebral 9l gliosarcomas, using bradykinin to disrupt the blood-tumor barrier. brain and internal organs were stained both for virus-mediated gene expression and for iron. quantitative comparisons of gene expres ...	1995	8664379
[a case of portal-systemic encephalopathy with slowly progressive, non-flapping tremor].	a 52-year-old man has slowly developed a non-flapping tremor during 30 years. he also had suffered from poor concentration for two years. he had, however, no history of episodic disturbance of consciousness. he had no other neurological symptoms except for tremor and hyperreflexia. the tremor was postural and intentional, and extremely increased at the end point. the factor of intentional tremor and hyperkinesia volitionnelle seems to be present in the tremor. laboratory examination disclosed a ...	1995	8665732
arthrodesis of the wrist for post-traumatic disorders.	we retrospectively reviewed the records of eighty-nine consecutive patients (ninety wrists) who had had a total arthrodesis of the wrist for the treatment of a post-traumatic disorder at one center. fifty-six patients (fifty-seven wrists) had the arthrodesis with plate fixation, and thirty-three patients (thirty-three wrists) had the arthrodesis with a variety of other techniques. the average age of the patients at the time of the arthrodesis was forty-two years, and the dominant wrist was treat ...	1996	8666608
dr. pader replies to dr. fisher (winter 1996)		1996	8668713
continual reassessment method: a likelihood approach.	the continual reassessment method as described by o'quigley, pepe, and fisher (1990, biometrics 46, 33-48) leans to a large extent upon a bayesian methodology. initial experimentation and sequential updating are carried out in a natural way within the context of a bayesian framework. in this paper we argue that such a framework is easily changed to a more classic one leaning upon likelihood theory. the essential features of the continual reassessment method remain unchanged. in particular, large ...	1996	8672707
complexes of myosin subfragment-1 with adenosine diphosphate and phosphate analogs: probes of active site and protein conformation.	previous work has revealed phosphate-dependent differences in the complexes formed from myosin subfragment-1 with adenosine diphosphate (s1.adp) and aluminum fluoride (alf4-) or beryllium fluoride (befx) [phan and reisler, biophys. j., 66 (1994) a78], with the former resembling more the s1**.adp.pi state while the latter resembles more the s1.atp state. in this work, the conformations of the s1.epsilon adp.alf4- and s1.epsilon adp.befx, complexes were examined by nucleotide chase and collisional ...	1996	8672721
gip-2 codon 179 oncogene mutations: absent in adrenal cortical tumors.	the role of g protein mutations in the pathogenesis of adrenal cortex neoplasms is controversial. two published studies disagree on the existence of a cysteine or histidine for arginine substitution at position 179 (r179c/h) of the gtp binding region of the alpha chain of an inhibitory g protein (gi2alpha) in these tumors. prior studies using detection by mutation-specific oligonucleotide hybridization showed either 3 of 11 or 0 of 56 tumors harbored mutations. to resolve this discrepancy and as ...	1996	8678943
overexpression of bcl-2 and mutations in p53 and k-ras in resected human non-small cell lung cancers.	we investigated expression of bcl-2, mutations in p53, and k-ras oncogene in 51 resected human non-small cell lung cancers. the studies were designed to test for the possibility of cooperativity between these oncogenes and p53 in the pathogenesis of lung cancer. an inverse relationship was found between expression of bcl-2 and mutant p53 by immunohistochemistry (p < 0.01; fisher exact test), suggesting that either bcl-2 overexpression or mutations in p53 may fulfill a critical function in the pa ...	1996	8679221
the possible role of tnf-alpha and il-2 in inducing tumor-associated metabolic alterations.	this study was conducted to investigate the role of tumor necrosis factor-alpha (tnf-alpha) and interleukin-2 (il-2) in inducing cancer cachexia, and the results were compared with those obtained from our previous study on fisher 344 rats with methylcholanthrene-induced sarcoma. three groups of male fisher 344 rats received one of the following regimens: 4 x 10(4) iu of human recombinant tnf-alpha per rat per day subcutaneously (sc) for 5 consecutive days (n = 5), 3.5 x 10(5) u human recombinant ...	1996	8680118
vocational outcome of aphasic patients following severe traumatic brain injury.	the incidence and course of aphasia, and its impact on vocational outcome, were determined in a group of 351 patients with severe traumatic brain injury (tbi). aphasia was found in 11.1%, the common forms being amnestic (56%, 22/39), expressive (10.3%, 4/39) and receptive (10.5%, 8/39), as found on the first language assessment. no age difference was found between the aphasic and non-aphasic patients. coma was more common in the aphasics than the non-aphasics (95% and 82%, respectively), althoug ...	1996	8680391
changing aids risk behavior: effects of an intervention emphasizing aids risk reduction information, motivation, and behavioral skills in a college student population.	this research used the information-motivation-behavioral skills (imb) model of aids risk behavior change (j. d. fisher & fisher, 1992a) to reduce aids risk behavior in a college student population. college students received an imb model-based intervention that addressed aids risk reduction information, motivation, and behavioral skills deficits that had been empirically identified in this population, or were assigned to a no-treatment control condition. at a 1-month follow-up, results confirmed ...	1996	8681919
second-trimester amniotic fluid or maternal serum interleukin-10 levels and small for gestational age neonates.	to evaluate if interleukin-10 levels in either early second-trimester amniotic fluid (af) or maternal serum can be utilized as a predictor of the subsequent occurrence of small for gestational age (sga) infants after controlling for gestational age at delivery.	1996	8684756
postoperative management of cesarean patients: the effect of immediate feeding on the incidence of ileus.	to evaluate the effect of immediate feeding on gastrointestinal function in patients undergoing cesarean delivery.	1996	8684757
the regulation by gender, strain, dose, and feeding status of the induction of multiple forms of cytochrome p450 isozymes in rat hepatic microsomes by 2,4,5,2',4',5'-hexachlorobiphenyl.	2,4,5,2',4',5'-hexachlorobiphenyl (hcb) induces hepatic microsomal cytochromes p450 with a similar selectivity for responsive genes to phenobarbital (pb). cyp2bl, cyp2b2, cyp2c6, cyp3al, and cyp2al each showed large strain differences in induction by hcb fisher f344 >> wistar furth (wf) that were much more evident in female rats, paralleling previous observations with pb. these five p450s and epoxide hydrolase were, however, induced more effectively by hcb than by pb and strain differences were ...	1996	8685906
retransplantation reverses mononuclear infiltration but not myointimal proliferation in a rat model of chronic cardiac allograft rejection.	episodes of acute rejection seem to play an important role in the development of chronic allograft failure. whereas acute rejection appears to be fully reversible, at least at early stages, reversibility of chronic graft alterations is still unclear. male fisher f344 rat hearts were heterotopically transplanted into lewis recipients (n=8/group). minimal immunosuppression (rapamycin 0.5 mg/kg for 14 days) guaranteed allograft survival during the observation period (group 1). allografted hearts we ...	1996	8685945
comparative biochemical effects of low doses of mercury ii chloride in the f344 rat and the multimammate mouse (mastomys natalensis).	the biochemical effects and comparative nephroxicity of mercury ii chloride (hgcl2) dosed at 0.75 mg/kg i.p. was investigated in the fisher 344 rat (f344) and mastomys natalensis using high resolution 1h nuclear magnetic resonance (nmr) spectroscopy of urine, histopathology and clinical chemical techniques. the effects of hgcl2 treatment were followed for up to 4 days post-dosing (p.d.). in f344 rats there was extensive proximal tubular damage and renal cortical necrosis together with elevated l ...	1996	8689530
ability of synthetic peptides representing epitopes of outer membrane protein f of pseudomonas aeruginosa to afford protection against p. aeruginosa infection in a murine acute pneumonia model.	three synthetic peptides (nos 9, 10 and 18) representing surface-exposed, linear b-cell epitopes of outer membrane protein f of pseudomonas aeruginosa were each conjugated to the carriers keyhole limpet hemocyanin (klh) and bovine serum albumin (bsa), with the conjugates being used to immunize mice intranasally. mice were also immunized intranasally with a klh/bsa carrier control or with a peptide no. 8 conjugate as a negative control. an immunoglobulin g response reactive with p. aeruginosa who ...	1995	8701588
augmenting kidney mass at transplantation abrogates chronic renal allograft injury in rats.	conventional renal transplantation, which substitutes a single allograft for two native kidneys, imposes an imbalance between nephron supply and the metabolic and excretory demands of the recipient. this discrepancy, which stimulates hyperfunction and hypertrophy of viable allograft nephrons, may be intensified by nephron loss through ischemia-reperfusion injury or acute rejection episodes occurring soon after transplantation. in other settings where less than 50% of the total renal mass remains ...	1996	8705732
[case of fisher syndrome with pemphigus treated by immuno-adsorption plasmapheresis].		1996	8708457
intrahospital transportation: monitoring and risks.	patients' intrahospital transport is considered as part of the mediconursing care continuum, since patients frequently need diagnostic or therapeutic procedures not performed at the bedside (waddell 1975, rutherford & fisher 1986). severe complications, such as airway obstruction, artificial airway or intravenous line removal, arterial blood gas and blood pressure changes, and arrhythmias or cardiac arrest, have been described during this transportation, especially in critically ill patients (ta ...	1996	8717820
timing of the thermographic assessment of burns.	the thermographic assessment of burns using infrared imaging has previously been shown to be a useful aid in the estimation of burn depth. in this study, thermographic images of burns, obtained from 65 patients over a 4-year period, were reviewed. an infrared transparent, water-impermeable membrane was used as a wound cover to abolish evaporative cooling artefacts. single images were obtained from patients with burns to various parts of the body, excluding the hands. a significant change in the ...	1996	8719312
microsurgical composite tissue transplantation at difficult recipient sites facilitated by preliminary installation of vein grafts as arteriovenous loops.	in microvascular surgery when local recipient vessels are inadequate, vein grafting is required. there are several potential inherent disadvantages of immediate vein grafting, including the development of graft thrombosis or leakage, an increased opportunity for technical errors, and an increased number of anastomoses in series. all of these may contribute to a higher failure rate for composite-tissue transplantation requiring vein grafts. the authors hypothesized that in cases where vein grafti ...	1996	8723834
electronic compliance assessment of antifungal prophylaxis for human immunodeficiency virus-infected women.	several prophylactic medications for opportunistic or recurrent infections are used in human immunodeficiency virus-infected individuals. essential to the efficacy evaluation of these agents is the accurate reporting of medication compliance. we hypothesized that poor patient compliance with thrice-weekly fluconazole prophylaxis would correlate with the occurrence of clinical events. fluconazole compliance was monitored electronically by using the medication event monitoring systems with 19 wome ...	1996	8725997
ageing potentiates anaesthetic-induced synaptic depression in hippocampal slices.	the effects of the volatile anaesthetic isoflurane on dendritic field excitatory postsynaptic potentials (fepsp) were compared in hippocampal slices taken from young mature and old fisher 344 rats. application of isoflurane (1% v/v) to young brain slices produced minimal effects on the recorded fepsps. on the contrary, the same anaesthetic concentration depressed field responses obtained from old hippocampal slices by 42 +/- 6.8% compared with baseline values. such increased sensitivity to anaes ...	1996	8730815
ritual and medicinal plants of the ese'ejas of the amazonian rainforest (madre de dios, perú).	the ese'eja is a hunter-fisher-gatherer tribe of amerindians which occupies the south-eastern part of perú. their culture cannot be disassociated from religious beliefs. disease can be caused by accident, distraction or indolence, or by evil powers. these evil powers come either from the direct action of a harmful shaman or by interactions with the devil. a description of shamanic practices is given to elucidate the position of health practices in ese'eja culture, which includes the use of medic ...	1996	8733119
immunohistochemical detection of bcl-2 protein in adenocarcinoma and non-neoplastic cellular compartments of the lung.	the expression of bcl-2 seems to influence the biologic activity of a variety of neoplasms. in this study, we examined bcl-2 protein expression in 47 surgically resected adenocarcinomas of the lung to determine its expression in the neoplastic and adjacent non-neoplastic cells. seven squamous cell carcinomas, six small cell carcinomas, five non-neoplastic lung lesions, and five normal lungs were also studied. the bcl-2 protein was detected after antigen retrieval with bcl-2 monoclonal antibody u ...	1996	8733771
rhinocerebral mucormycosis: predisposing factors, diagnosis, therapy, complications and survival.	mucormycosis is the most acutely fatal fungal infection of the human being (5). although relatively uncommon, its morbidity makes it an extremely important disease for the otolaryngologist-head and neck surgeon. a review of 11 cases of rhinocerebral mucormycosis (nine female and two male patients) admitted from 1961 to 1994 at hospital das clinicas, university of sao paulo was undertaken. the age range was from eight months to 49 years with a median age of 31 years. in the current study, we pres ...	1996	8734267
[prevalence of hepatitis c virus in urban and rural populations of northeast brazil-pilot study].	hepatitis c virus can be found in all continents. however, differences exist with respect to its prevalence. in brazil, epidemiological data are scarce, and are based, in their majority, on information obtained from blood donors and not from the general population. our objective is to show the prevalence of anti-hcv in two distinct populations: one rural and one urban: salvador, a metropolis, and castro alves, a rural village with very little contact with other populations. eight hundred individ ...	1995	8734852
arthroscopic anterior labral reconstruction using a transglenoid suture technique. results in active-duty military patients.	we report the clinical outcome of arthroscopic labral reconstruction using a transglenoid suture technique in a young, active-duty military population. forty-eight patients (49 shoulders) with varying degrees of glenohumeral instability underwent arthroscopic labral reconstruction using a transglenoid suture technique. all patients had traumatic injuries to their shoulders and all patients had magnetic resonance imaging scans demonstrating anterior labral tears. postoperatively, the patients' sh ...	2017	8734874
mixor: a computer program for mixed-effects ordinal regression analysis.	mixor provides maximum marginal likelihood estimates for mixed-effects ordinal probit, logistic, and complementary log-log regression models. these models can be used for analysis of dichotomous and ordinal outcomes from either a clustered or longitudinal design. for clustered data, the mixed-effects model assumes that data within clusters are dependent. the degree of dependency is jointly estimated with the usual model parameters, thus adjusting for dependence resulting from clustering of the d ...	1996	8735023
leeds undergraduate medical education conference, 7-8 july 1995.	the leeds undergraduate medical education conference (lumec) was held on 7-8 july 1995. this conference, devoted entirely to undergraduate medical education, was unique in that it was organized entirely by four medical students. it attracted a wide and enthusiastic audience and excellent speakers. professor charles george (chairman, education committee, general medical council) spoke about tomorrow's doctors, dr mark bailey (part-chairman, medical students' committee of the british medical assoc ...	1996	8736251
signalling by protein kinase c isoforms in the heart.	understanding transmembrane signalling process is one of the major challenge of the decade. in most tissues, since fisher and krebs's discovery in the 1950's, protein phosphorylation has been widely recognized as a key event of this cellular function. indeed, binding of hormones or neurotransmitters to specific membrane receptors leads to the generation of cytosoluble second messengers which in turn activate a specific protein kinase. numerous protein kinases have been so far identified and roug ...	2017	8739230
i/d polymorphism at the locus for ace and apo a-i gene promoter polymorphism as risk factors for coronary artery disease in patients with familial hypercholesterolemia.	in our study we searched for an association between the insertion/deletion (i/d) polymorphism at the ace locus as well as apo a-i promoter polymorphism and coronary artery disease (cad) in patients with familial hypercholesterolemia (fh). 34 fh patients over 40 years were ascertained; 16 patients with cad were compared with 18 patients without cad. there was an excess of dd or id genotype in fh patients with cad (or = 4.9, ci = 1.17-22.17; fisher exact p = 0.012), however, no association between ...	1996	8739332
serial mri, vep, sep and biotesiometry in acute optic neuritis: value of baseline results to predict the development of new lesions at one year follow up.	in an attempt to establish the value of mri, vep, sep, and biotesiometry in monitoring disease evolution we undertook a one year follow up study of 70 untreated patients with acute optic neuritis (on).	1996	8739433
[lymph node involvement and prognosis in medullary cancers of the thyroid gland].	involvement of regional lymph nodes is extremely common in medullary carcinoma of the thyroid gland (mtc). the aim of the present study was to determinate the prognostic of mtc correlated with the regional lymph node involvement. from 1975 to 1994, 23 mtc patients were treated. the surgical protocol included a total thyroidectomy with bilateral dissection of the jugulocarotid chain and of the paratracheal groove. we have distinguished two groups: group n+ (histological lymph nodes involvement) a ...	2006	8746014
expression of ltp by ampa and/or nmda receptors is determined by the extent of nmda receptors activation during the tetanus.	1. we have tested, in ca1 hippocampal slices, the hypothesis that the expression of long-term potentiation (ltp) by alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) and/or n-methyl-d-aspartate (nmda) receptors depends on the degree of nmda receptors activation during the tetanus. 2. slices were perfused in an artificial cerebrospinal fluid (acsf) containing glycine (1 microm), bicuculline (5 microm) and a low mg2+ concentration (0.3 mm). to measure the ampa and nmda receptor-media ...	1995	8747197
amount of subarachnoid blood and vasospasm: current aspects. a transcranial doppler study.	subsequent to admission after aneurysmal subarachnoid haemorrhage (sah), 120 patients (74 women and 46 men) underwent microsurgical clipping of a total of 158 cerebral aneurysms within 96 hours after the bleed. their mean age was 46 (20-91) years. computed tomography (ct) findings were graded according to the modified fisher scale and all patients had daily transcranial doppler (tcd) recordings of their basal cerebral arteries. in 19% of sah was grade i on ct, in 44% grade ii and in 37% grade ii ...	1995	8748829
discrimination of patients with acoustic neuroma and peripheral vestibular lesions with human posture dynamics.	a group of normal subjects (n = 17) was compared with groups of patients with a diagnosis of vestibular neuritis (n = 18), and acoustic neuromas (n = 35). fisher linear discriminant analysis was applied to distinguish clusters of parameters characteristic for each disease. hence it was possible to distinguish the vestibular neuritis patients from the normal group with statistical significance (p < 0.01). also the patients with an acoustic neuroma could be distinguished from the normal subjects w ...	1995	8749072
hospital resource utilization in the treatment of cerebral aneurysms.	the authors reviewed clinical and financial data for all patients treated for nontraumatic subarachnoid hemorrhage (sah) and unruptured cerebral aneurysms at their institution between june 1993 and december 1994. this study sought to identify specific areas of high resource utilization that may be amenable to reduction of expenditures without compromising quality of care. detailed hospital financial data were correlated with clinical grade and course. areas of high resource use were identified b ...	1996	8751624
blood-brain barrier breach following cortical contusion in the rat.	adult fisher 344 rats were subjected to a unilateral impact to the dorsal cortex above the hippocampus at 3.5 m/second, resulting in a 2-mm cortical depression. this caused severe cortical damage and neuronal loss in hippocampus subfields ca1, ca3, and hilus. breakdown of the blood-brain barrier (bbb) was assessed by injecting the protein horseradish peroxidase (hrp) 5 minutes prior to or at various times after injury (5 minutes, 1, 3, 6, and 12 hours, 1, 2, 5, and 10 days). animals were killed ...	1996	8751635
hla-dr5 and dqb1*03 class ii alleles are associated with cutaneous t-cell lymphoma.	cutaneous t-cell lymphoma (ctcl) may present with eczematous lesions, mycosis fungoides (mf), or as exfoliative erythroderma with circulating atypical cells, sezary syndrome (ss). the "malignant" t cells are epidermotropic and clonal, but whether they respond to antigen stimulation is unknown. because cd4+ lymphocytes recognize antigen presented by histocompatibility locus antigen (hla) class ii molecules, and hla association have been found in autoimmune skin diseases, we determined by allele-s ...	1996	8751973
[antiglycolipid antibody in inflammatory neuropathy].	antiglycolipid antibody is frequently detected in the acute phase sera from patients with acute inflammatory demyelinating polyneuropathy (guillain-barré syndrome, gbs). the titer is highest in the serum sample taken first after the neurological onset, and decreases with clinical improvement. antiglycolipid antibody may play a role in the pathogenetic mechanism of gbs. gm1 and gd1b are the antigens most commonly recognized. monoclonal anti-gd1b antibody specifically bound to the paranodal myelin ...	1995	8752399
[removal ability of igg anti-gq1b antibody in immunoadsorption therapy for fisher syndrome--comparison of the removal ability between tryptophane column and phenylalanine column].	anti-gq1b antibody seems to be a pathogenetic factor in the development of fisher syndrome (fs). although several patients received immunoadsorption therapy (iat), whether it can remove the autoantibody has not yet been clarified. we treated two patients with fs by iat using tryptophane column (tr-c) and phenylalanine column (ph-c) (tr-c; 9 times altogether in 2 patients, ph-c: twice altogether in 2 patients), and compared the removal ability of igg anti-gq1b antibody and immunoglobulin between ...	1996	8752688
miller-fisher syndrome associated with campylobacter jejuni bearing lipopolysaccharide molecules that mimic human ganglioside gd3.	a campylobacter jejuni strain of serotype o:10 was isolated from a patient who had miller-fisher syndrome. in its biochemical reactions and cellular morphology, the isolate was characteristic of typical c. jejuni. antibodies against extracted lipopolysaccharide (lps) were detected by passive hemagglutination in the acute- and convalescent-phase patient sera. by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting with the o:10 antiserum, it was demonstrated that the strai ...	1996	8757818
attachment of vibrio alginolyticus to chitin mediated by chitin-binding proteins.	vibrio alginolyticus is the only culturable vibrio associated with the chitinaceous carapace of the copepod tigriopus fulvus (fisher 1860) living in ligurian coastal rock pools (tyrrhenian sea). the characteristics of the interaction between chitin particles and v. alginolyticus were studied by analysing strains isolated both from the copepod surface and from rock-pool water. the highest degree of attachment to chitin was observed at 20 degrees c, in the presence of 3% nacl. bacterial treatment ...	1996	8760933
decreased plasma membrane calcium transport activity in aging brain.	we have assessed the functional properties of both calmodulin (cam) and the plasma membrane ca(2+)-atpase in brains of young, middle aged, and old fisher 344 rats. under optimal conditions of saturating ca2+ and atp, the cam-activated ca(2+)-atpase activity was decreased with increasing age, particularly when cam isolated from the brains of aged rats was used to stimulate the enzyme. in the case of cam, structural modifications within the primary sequence of the protein from aged brains were ide ...	1996	8761328
[recurrent idiopathic facial paralysis and other cranial nerve involvements in 2 members of a family].	we report 2 cases of the same family who presented with alternating recurrent episodes of peripheral facial palsy, associated in one case with ipsilateral trigeminal neuropathy and preceded in the other case by incomplet miller-fisher syndrom. all laboratory and radiological investigations were normal except the electrodiagnostic tests. the etiopathogenetic mecanisms implied and the distinction between familial recurrent bell's palsies and recurrent cranial nerve palsies are discussed.	1996	8763660
photodynamic therapy: a promising new modality for the treatment of cancer.	the first reports on photodynamic therapy (pdt) date back to the 1970s. since then, several thousands of patients, both with early stage and advanced stage solid tumours, have been treated with pdt and many claims have been made regarding its efficacy. nevertheless, the therapy has not yet found general acceptance by oncologists. therefore it seems legitimate to ask whether pdt can still be described as "a promising new therapy in the treatment of cancer". clinically, pdt has been mainly used fo ...	1996	8765658
[psychological stress on patients in tumor after-care after r0 resection of colorectal carcinomas].	in a prospective study 70 patients after curative resection for colorectal carcinoma were asked about the psychological strain in the follow-up program. of these patients, 80.1% felt that they did the right thing and 70% were optimistic and confident regarding the follow-up examinations. only 5 patients (7.1%) had no intention of keeping the follow-up appointment and 12 patients (17.1%) were thinking about recurrence. the patients were afraid of further examinations, and the majority (45 patient ...	1996	8767088
[air conditioning with a high-performance hme (heat and moisture exchanger)--an effective and economical alternative to active humidifiers in ventilated patients. a prospective and randomized clinical study].	heat and moisture exchangers (hme) are used as artificial noses for intubated patients to prevent damage resulting from dry and cold inspired gases. hme collect a large fraction of the heat and moisture of the expired air, adding them to the subsequent inspired breath. in a prospective clinical study the air conditioning capacity of a heated humidifier was compared with a hygroscopic hme. methods. the water content of the ventilated air of 49 intensive care patients requiring artificial ventilat ...	1996	8767565
ramstedt's pyloromyotomy--what is the correct incision?	to retrospectively review starship's complication rates of the vertical midline incision and transverse right upper quadrant incision in ramstedt's pyloromyotomy.	1996	8769050
classification of veterans with post-traumatic stress disorder using visual brain evoked p3s to traumatic stimuli.	post-traumatic stress disorder (ptsd) typically involves a re-experiencing of traumatic events. in a previous p3 study it was found that ptsd patients react both selectively and involuntarily to combat-related pictures, exhibiting augmented p3 event-related potentials and thus providing a brain activity measure. the clinical application of these findings in differentiating ptsd patients from controls was tested.	1996	8770439
the influence of perinatal infective factors on ophthalmia neonatorum.	ophthalmia neonatorum still blinds approximately 10,000 babies annually worldwide. identification of contributory maternal perinatal factors could possibly predict which babies are at greater risk for this disease.	2013	8771523
lipid peroxidation in rats administrated with mercuric chloride.	parenteral administration of mercuric chloride (hgcl2) to rats enhanced lipid peroxidation in liver, kidney, lung, testis, and serum (but not in heart, spleen, or muscle), as measured by the thiobarbituric acid reaction for malondialdehyde (mda) in fresh tissue homogenates and body fluids. after sc injection of hgcl2 (5 mg/kg body wt), mda concentrations in liver and kidney became significantly increased by 9 h and reached peak values at 24 h. dose-response studies were carried out with male alb ...	1996	8773760
preoperative ketorolac increases bleeding after tonsillectomy in children.	to compare the incidence of vomiting following codeine or ketorolac for tonsillectomy in children.	1996	8773860
celiac disease with cerebral calcium and silica deposits: x-ray spectroscopic findings, an autopsy study.	an increased incidence of seizures and cerebral calcifications, usually bilateral and located in the occipital cortex, has been reported in celiac patients. the histology of cerebral lesions is not well defined, and their pathogenesis is only speculative. we report the autopsy results of a patient with celiac disease, seizures, and cerebral calcifications who died following a cerebral hemorrhage caused by fisher-evans syndrome. calcifications were restricted to the cortical gray matter and compo ...	1996	8780097
evaluation of 1-azabicyclo[2.2.2]oct-3-yl alpha-fluoroalkyl-alpha-hydroxy-alpha-phenylacetates as potential ligands for the study of muscarinic receptor density by positron emission tomography.	both 1-azabicyclo[2.2.2]oct-3-yl alpha-(1-fluoroeth-2-yl)-alpha-hydroxy-alpha-phenylacetate (fqne, 5) and 1-azabicyclo[2.2.2]oct-3-yl alpha-(1-fluoropent-5-yl)-alpha-hydroxy-alpha-phenylacetate (fqnpe, 6) were prepared and evaluated as potential candidates for the determination of muscarinic cholinergic receptor (machr) density by positron emission tomography (pet). the results of in vitro binding assays demonstrated that although both 5 and 6 had high binding affinities for m1 and m2 machr subt ...	1996	8782236
first person account: a voice from another closet.	the article that follows is part of the schizophrenia bulletin's ongoing first person accounts series. we hope that mental health professionals--the bulletin's primary audience--will take this opportunity to learn about the issues and difficulties confronted by consumers of mental health care. in addition, we hope that these accounts will give patients and families a better sense of not being alone in confronting the problems that can be anticipated by persons with serious emotional difficulties ...	1996	8782294
cytotoxic effects of kainate ligands on hek cell lines expressing recombinant kainate receptors.	exposure of neurons either for prolonged periods of time or to high concentrations of excitatory amino acids (eaa), such as glutamate, results in neuronal death. kainate also causes cell toxicity through the glutamate receptors. however, it is unclear whether the kainate receptor itself mediates any of the toxic responses. in the present study, hek cells expressing the glur6 +/- ka2 receptor subunit(s) were studied for their susceptibility to toxicity through the kainate receptor by kainate liga ...	1996	8782898
laser-evoked cerebral potentials and sensory function in patients with central pain.	central pain syndromes (cps) could be caused by disinhibition of spinothalamic excitability or by other central nervous system (cns) changes caused by reduced spinothalamic function. to examine these possibilities, we studied 11 patients (ages 51-82 years) with unilateral central pain and with reproducible cerebral evoked vertex potentials in response to cutaneous stimulation of the normal side with pulses from an infra-red co2 laser. all patients had normal tactile and kinesthetic sensation; on ...	1996	8783313
the influence of high-energy shock waves on the development of metastases.	the hypothesis that exposure of a solid tumor to high-energy shock waves (hesw) could lead to an increase of metastases was investigated in an animal model. the highly metastatic at-6 dunning r3327 rat prostate cancer subline was implanted in the hind limb of a fisher-copenhagen rat and was exposed to 6000 shock waves delivered by an experimental lithotripter, or sham-treated, as soon as the tumor had reached a volume of 175-225 mm3. the tumor-bearing leg was amputated 24 h later and the number ...	1996	8783466
exposure to methyl mercury results in serum autoantibodies to neurotypic and gliotypic proteins.	environmental exposure to methyl mercury (mehg) continues to pose a threat to humans, making early detection of neurotoxic effects a pressing concern. an enzyme-linked immunosorbent assay (elisa) to measure serum autoantibodies (ig) to neurotypic and gliotypic proteins [neurofilament triplet (nf68; nf160; nf200), myelin basic protein (mbp) and glial fibrillary acid protein (gfap)] as markers of subclinical neurotoxicity was developed and tested in fisher 344 rats exposed orally to 16 or 32 ppm m ...	1996	8784838
extensive absorption of 2',3'-dideoxyinosine by intratracheal administration in rats.	to evaluate the intratracheal route of administration as an alternative to oral administration for 2',3'-dideoxyinosine (ddi).	1995	8786964
age-related changes in bindings of second messengers in the rat brain.	age-related alterations in bindings of major second messengers in the brain were studied in 3-week- and 6-, 12-, 18- and 24-month-old fisher 344 rats using receptor autoradiography. [3h]phorbol 12,13-dibutyrate (pdbu) and [3h]forskolin were used to label protein kinase c (pkc) and adenylate cyclase, respectively. in immature rats (3-week-old), [3h]pdbu binding showed a significant decrease only in the cerebellum as compared to adult rats (6-month-old), whereas [3h]forskolin binding exhibited a s ...	1995	8788918
penetrating trauma of the internal carotid artery.	to assess management of penetrating internal carotid artery (ica) injuries.	1996	8790179
mixreg: a computer program for mixed-effects regression analysis with autocorrelated errors.	mixreg is a program that provides estimates for a mixed-effects regression model (mrm) for normally-distributed response data including autocorrelated errors. this model can be used for analysis of unbalanced longitudinal data, where individuals may be measured at a different number of timepoints, or even at different timepoints. autocorrelated errors of a general form or following an ar(1), ma(1), or arma(1,1) form are allowable. this model can also be used for analysis of clustered data, where ...	1996	8800609
regional age-related alterations in cholinergic and gabaergic receptors in the rat brain.	the age-related changes of cholinergic and gamma-aminobutyric acid (gaba)ergic receptors were studied in 3-week- and 6-, 12-, 18- and 24-month-old fisher 344 male rat brains using receptor autoradiography. [3h]quinuclidinyl benzilate (qnb), [3h]hemicholinium-3 (hc) and [3h]muscimol were used to label acetylcholine receptors, acetylcholine reuptake sites and gabaa receptors, respectively. in immature rats (3-week-old), [3h]qnb and [3h]muscimol binding showed a significant increase in most brain a ...	1996	8803921
evidence for dna fragmentation in the cns of aged fischer-344 rats.	the aged central nervous system (cns) is characterized by a loss of neurons. apoptosis has been reported to be responsible for neuronal death during development and may also be involved in some age-related neurodegenerative diseases of the cns. no evidence is currently available as to whether apoptosis is also responsible for the loss of neurons associated with physiological aging. in this study, we have found fragmented dna, a characteristic trait of cells undergoing apoptosis, in the hippocamp ...	1996	8804034
the systemic administration of tacrine or selegiline facilitate spatial learning in aged fisher 344 rats.	when compared to young fisher 344 rats, aged fisher 344 rats were impaired in their acquisition of the water maze task as indicated by longer escape latencies and distances to find a hidden platform. in a free swim trial which was performed after the training period, young rats had a better spatial bias, since they spent more time swimming in the previous training quadrant. tacrine 3 mg/kg, an anticholinesterase, and selegiline 0.25 mg/kg, a mao-b inhibitor, partially reversed the acquisition de ...	1996	8811506
microglial cell responses to fetal ventral mesencephalic tissue grafting and to active and adoptive immunizations.	microglia express cytokines, major histocompatibility (mhc) loci, and several other immunologically important constituents. the aim of this study was to detect immunological responses of microglial cells following allogeneic dopaminergic transplantation using active and adoptive immunizations. adult inbred fisher 344 (f344 rt1) rats were unilaterally dopamine (da) depleted in striatum by injection of 6-hydroxydopamine. the degree of degeneration was assessed by recording the rotational response ...	1996	8812150
carcinogenicity of the anticancer topoisomerase inhibitor, amsacrine, in wistar rats.	amsacrine is an antineoplastic drug used in the treatment of acute adult leukemias. to assess its carcinogenic potential, groups of 50 male and 50 female rats were administered amsacrine by lateral tail vein injection at 0 (vehicle control), 0.25, 1, or 3 mg/kg once daily for 5 days, followed by a 23-day recovery period. this cycle of dosing and recovery was repeated a total of six times. the animals were then maintained without dosing for an 18-month observation period. during the dosing phase, ...	1996	8812222
rat to human extrapolation of hcfc-123 kinetics deduced from halothane kinetics: a corollary approach to physiologically based pharmacokinetic modeling.	the goal of this study was to develop a human physiologically based pharmacokinetic (pbpk) model for the chemical hcfc-123 (2,2-dichloro-1,1,1-trifluoroethane) and its major metabolite, trifluoroacetic acid (tfa). no human kinetic data for hcfc-123 are available, thus a corollary approach was developed. hcfc-123 is a structural analog of the common anesthetic agent halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) and follows a common pathway of oxidative biotransformation, resulting in the for ...	1996	8812223
design and evaluation of an olfactometer for the assessment of 3-methylindole-induced hyposmia.	few studies objectively evaluate olfactory function in animals following exposure to chemicals that induce nasal toxicity. an olfactometer capable of generating a reproducible olfactory stimulus and measuring an odorant-cued behavioral response was developed for rats from a commercially available two-way shuttle box. the box was modified to deliver the test odorant, acetaldehyde, to either of two chambers separated by a physical barrier consisting of a downward-directed airwall sandwiched betwee ...	1996	8812225
metallothionein induction and pulmonary responses to inhaled cadmium chloride in rats and mice.	inhaled cdcl2 is a pulmonary carcinogen in rats but not in mice. we hypothesized that pulmonary metallothionein (mt) induction may be different in both species and thereby may lead to different levels of protection from cd-induced lung injury. fisher-344 rats and b6c3f1 mice were exposed for 4 weeks to cdcl2 aerosols of 0, 30, 50, and 150 micrograms/m3 air or 0, 10, 30, and 100 micrograms/m3 air, respectively. animals from each exposure group were terminated at 1, 30 and 133 days after the end o ...	1996	8812267
development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male fisher-344 rats.	methyl tertiary-butyl ether (mtbe) and its metabolite tertiary-butanol (tba) both cause renal tumors in chronically exposed male rats. knowledge of the kinetic behavior of mtbe and tba in rats and its comparison to the kinetics of these chemicals in humans will aid in assessing human risk. the objective of this study was to develop a physiologically based pharmacokinetic (pbpk) model for mtbe and tba in rats that will form the basis for a human model. physiological parameters such as blood flows ...	1996	8812274
interactions of neurotrophic factors gdnf and nt-3, but not bdnf, with the immune system following fetal spinal cord transplantation.	glial cell line-derived neurotrophic factor (gdnf) is known to stimulate survival of dopaminergic and spinal cord motor neurons. however, little is known of the possible immune sequelae of gdnf exposure, or that of other putative trophic factors. to address these questions we utilized in oculo grafts of spinal cord, wherein we could induce different levels of immune responses via allogeneic vs. syngeneic combinations. adult female sprague-dawley and fisher rats were used as hosts for allogeneic ...	1996	8813361
upper extremity deep venous thrombosis in cancer patients with venous access devices--prophylaxis with a low molecular weight heparin (fragmin).	central venous access devices are often essential for the administration of chemotherapy to patients with malignancy, but its use has been associated with a number of complications, mainly thrombosis. the true incidence of upper extremity deep vein thrombosis (dvt) in this setting is difficult to estimate since there are very few studies in which dvt diagnosis was based on objective tests, but its sequelae include septic thrombophlebitis, loss of central venous access and pulmonary embolism. we ...	1996	8815570
antitumoral local effect and metastatic risk of focused extracorporeal pyrotherapy on dunning r-3327 tumors.	we evaluated the effect of focused extracorporeal pyrotherapy on local tumor growth and metastatic potential of the dunning r-3327 tumor inoculated into male copenhagen fisher rats, using the highly metastatic mat ly lu cell line in 64 rats and the slightly metastatic g cell line in 60 rats. five million cells were inoculated subcutaneously into a lower limb and the tumor volume was determined every 48 h. the local effect, the presence of lung and/or lymph node metastases and the spontaneous sur ...	1996	8821695
increased bcl-2 protein levels in prostatic adenocarcinomas are not associated with rearrangements in the 2.8 kb major breakpoint region or with p53 protein accumulation.	bcl-2, an inhibitor of programmed cell death (apoptosis), is present in high levels in a subset of prostatic adenocarcinomas. in this study, 42 prostatic adenocarcinomas were analyzed to determine whether increased bcl-2 levels are associated with rearrangements in the 2.8-kb major breakpoint region, an association known to occur in certain follicular lymphomas featuring a t(14:18) translocation. immunostaining for bcl-2 and p53 proteins was performed on formalin-fixed, paraffin-embedded tumor s ...	1996	8821955
metabolic rate, organ mass, and mitochondrial proton leak variations in lean and obese rats.	the purpose of this study was to determine if differences in metabolic rate between lean and obese strains of rats were associated with differences in proton leak across the inner mitochondrial membrane. metabolic rates were determined for each of five obese zucker, sprague-dawley, and fisher 344 rats and three lean zucker rats by 24-hour indirect respiration calorimetry measurements. feed intakes were different (p < 0.05) among all strains, with the obese zucker rats having the greatest intakes ...	1996	8829800
[a study of soluble form of l-selectin in blood of patients with neuroimmunological disorders].	members of the selection family mediate the first step of leukocyte-endothelial cell interaction in inflammatory lesion. we have examined the soluble form of l-selectin (sl-selectin) in patients with neuroimmunological disorders (48 multiple sclerosis, 2 balo's sclerosis, 18 guillain-barré syndrome, 7 miller-fisher syndrome, 8 chronic inflammatory demyelinating polyneuropathy, and 25 human t-lymphotropic virus type-1 associated myelopathy). the levels of sl-selectin were measured by monoclonal a ...	1996	8831172
infections and reduced functioning kidney mass induce chronic rejection in rat kidney allografts.	the etiology of chronic rejection of kidney allografts is unknown, although hyperfiltration, acute rejection, viral infection and initial graft ischemia have been implicated. to test whether endothelial activation may be the link between these factors and chronic rejection, the endotoxin (lipopolysaccharide-lps), a potent activator of endothelial cells, was evaluated in an established chronic rejection model. bilaterally nephrectomized lewis recipients of orthotopically transplanted fisher 344 k ...	1996	8832148
intermediate filament change in astrocytes following mild cortical contusion.	astrocytes are known to become reactive as a result of various types of lesions. they upregulate astrocytic-specific intermediate filament glial fibrillary acidic protein (gfap) and show a positive signal for the intermediate filament vimentin, a protein primarily found in developing astrocytes. an animal model for cortical contusions has been developed that manifests many of the neuropathologies seen in human closed head injury. the model involves an electronic controlled pneumatic impact devic ...	1996	8833197
glial cell line-derived neurotrophic factor enhances survival and growth of prenatal and postnatal spinal cord transplants.	glial cell line-derived neurotrophic factor was first described as a trophic factor for developing dopamine neurons. however, it has been shown that glial cell line-derived neurotrophic factor messenger rna is also expressed in several areas of the developing brain and spinal cord, suggesting that it may have additional roles in the nervous system. intraocular transplantation of neural tissue provides a unique method to examine in vivo effects of trophic factors. we have therefore studied the ef ...	1996	8834405
implementation of ospop, an algorithm for the estimation of optimal sampling times in pharmacokinetics by the ed, eid and api criteria.	the most common approach to optimize the sampling schedule in parameter estimation experiments is the d-optimality criterion, which consists in maximizing the determinant of the fisher information matrix (max det f). in order to incorporate prior parameter uncertainty in the optimal design, other criteria have been proposed: the ed = max e (det f), eid = min e (l/det f) and api = max e (log det f) criteria, where the expectation is with respect to the given prior distribution of the parameters. ...	1996	8835836
differential immune responses to fetal intracameral spinal cord and cortex cerebri grafts.	while the central nervous system (cns) has been characterized as an immunologically privileged site, there are also several reports describing immunological reactions within the cns. a certain degree of immunological privilege has also been ascribed to the anterior chamber of the eye. we have used the intraocular transplantation model to study immunological reactions in transplants of embryonic neural tissue. outbred sprague-dawley rats and inbred fisher rats were used. pieces of rat parietal co ...	1996	8836687
homicide in homosexual victims: a study of 67 cases from the broward county, florida, medical examiner's office (1982-1992), with special emphasis on "overkill".	forensic pathologists often state that homosexual homicides are more violent than those with heterosexual victims. overkill or wounding far beyond that required to cause death is a frequently used descriptor of these deaths. we quantified the number and extent of injuries between homosexual and heterosexual homicide victims to determine whether one group suffered more violence than the other. this case-control study involved 67 homosexual homicide victims and 195 age, race, and gender-matched he ...	1996	8838474
forced swimming behavior is not related to the corticosterone levels achieved in the test: a study with four inbred rat strains.	the behavior of four inbred strains of rats in the holeboard and the forced swimming tests, and its relationship with a physiological index of stress (serum corticosterone) were studied in adult male rats. the strains were: fisher 344 (fis), lewis (lew), spontaneously hypertensive (shr), and wistar-kyoto (wky). in the holeboard, shr rats were the most active and wky the less active, the other strains showing intermediate levels of activity. during the first exposure to forced swimming wky were f ...	1996	8838618
prediction of lethal or life-threatening cardio-circulatory events in patients who apparently are not at risk : a preliminary retrospective echocardiographic study.	major cardio-circulatory events, defined as circulatory death, myocardial infarction, unstable angina, or stroke, sometimes occur unexpectedly in patients who apparently have no evident increase in risk (absence of overt heart failure, hypertrophy, uncontrolled or severe hypertension, previous or present myocardial infarction, angina, myocarditis, infectious or any other pericardial, valvular or great vessel disease, heart malformation, significant arrhythmia or conduction disturbances). to inve ...	1996	8840215
cholinergic deafferentation enhances rat hippocampal pyramidal neuron responsiveness to locally applied nicotine.	we tested whether cholinergic denervation of the hippocampus of young rats would result in an enhancement of ca1 pyramidal cell responsiveness to nicotine. electrolytic lesions of the medial septal area were performed in young male fisher 344 rats. one month later the rats were anesthetized with pentobarbital and nicotine was locally applied to ca1 pyramidal neurons using pressure microejection. the dose of nicotine required to excite the pyramidal neurons was significantly lower for cells recor ...	1996	8842401