Publications

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[etiology of sarcoidosis in the light of a new histological demonstration method for mycobacteria]. 19654160204
observations on the morphological changes in myco. leprae in leprosy. 19654160467
morphology of mycobacterium leprae in tissue sections. 19674164667
the lack of effect of methimazole therapy in lepromatous leprosy. reassessment by examination of bacterial morphology. 19674165669
microscopic, cultural and serologic studies on mycobacterium leprae and other mycobacteria isolated from leprosy patients. 19674165670
leprosy. a preliminary review of the experimental evaluation of drugs for the treatment of leprosy. 19674167891
effect of ultraviolet irradiation on the acid-fastness of difficult to culture and unculturable mycobacteria. 19684170358
drug resistance of mycobacterium leprae, particularly to dds. 19674173566
leprosy. 19684175655
the surface structure of m. leprae. 19684177793
staining conditions influencing morphological index of acid-fast bacilli. 19684178297
[determination of the viability of leprosy mycobacteria by the cytochemical method]. 19674179208
immunoelectrophoretic study on the plasma protein of mice inoculated with several sorts of mycobacteria, in particular, with m. leprae and m. lepraemurium in the foot pad. 19674183179
erythema nodosum leprosum: a clinical manifestation of the arthus phenomenon. 19694186599
morphology of mycobacterium leprae in tissue sections. correlation with results of mouse foot pad inoculation. 19694187027
studies on mott bacilli (mycobacteria other than tubercle bacilli). 19704190045
an electron microscope study of the band structure of the leprosy bacillus and other mycobacteria. 19694190094
the evaluation of present antileprosy compounds. 19694190238
an improved method for the fluorochrome staining of mycobacteria in tissues and smears. 19704190442
biology of the mycobacterioses. a retrospective review of mycobacteria and the diseases they cause. 19684191743
[new methods of experimental chemotherapy in leprosy]. 19694191849
studies of immune mechanisms in leprosy. ii quantitative relationships of igg, iga, and igm immunoglobulins. 19704192266
[experience with the demonstration of mycobacterium leprae by the "thick drop" method according to markianos and nasal swab preparations]. 19684194413
[experience in the experimental study of leprosy]. 19734196880
immunological reactions of mycobacterium leprae and mycobacterium lepraemurium grown in cayman. 19734197246
immunochemical characteristics and differentiation of nocardiae. 19734202913
[pathogenic mycobacteria in dermatology (author's transl)]. 19734203417
particulate nature of o-diphenoloxidase in mycobacterium leprae and assay of the enzyme by the radioisotope technique. 19734204390
a century of progress in experimental leprosy. 19734205081
the growth of mycobacterium leprae in snakes. 19744207054
bcg antibody profiles in tuberculoid and lepromatous leprosy.in sera from 12 patients with polar tuberculoid leprosy, 12 with subpolar tuberculoid leprosy, and 16 with lepromatous leprosy were demonstrated a total number of 125 anti-bcg precipitins by means of crossed immunoelectrophoresis with intermediate gel. up to 14 different precipitins were found in individual sera, and the complexity in antibody response was higher than previously realized. the specificity of 69% of the antibodies was defined, and these antibodies were titrated in three arbitrary ...19744207518
dopa metabolism by mycobacterium leprae: its implications in culture of the bacillus and chemotherapy of leprosy. 19734207691
[cross reactions in the serological diagnosis of chagas' disease and kala-azar including sera of tuberculous and leprous patients (author's transl)]. 19744207936
immune response to mycobacterium leprae in indeterminate leprosy patients. 19734209177
detection of biological false positive syphilis serum reactions. 19744209642
potential antileprotic agents. 3. inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines. 19744209923
the problem of cultivation of mycobacterium leprae. a review with criteria for evaluating recent experimental work.some criteria are presented to help evaluate papers appearing in the literature claiming successful cultivation of m. leprae either in the absence or in the presence of tissue-cultured cells. recently, electron microscopic studies have definitely shown m. leprae to belong to the genus mycobacterium and its division to occur through transverse section. a survey is given of the mycobacterial strains isolated in the last 10 years from leprosy lesions. these strains belong to taxonomically different ...19734212439
an investigation of takahashi's antitubercle phosphatide kaolin agglutination test (kat) in leprosy. 19744212936
antimycobacterial antibodies in sera from patients throughout the clinico-pathological disease spectrum of leprosy. 19744215284
[prospect of tuberculosis research. in reference to bacteriological aspect (author's transl)]. 19744218277
[an epidemiologist's viewpoint of leprosy]. 19684233037
recent advances in experimental leprosy. 19704244234
bcg vaccination of children against leprosy. preliminary findings of the who-controlled trial in burma.the use of bcg vaccine in the prevention of leprosy has been one of the most important subjects of investigation in the field of leprology in the last 25 years. the action of the vaccine was for many years investigated by determining its effect on the lepromin reaction. field studies were later considered essential to determine whether bcg vaccination would be useful to leprosy contacts, to the child population probably exposed to infection, or to persons persistently lepromin-negative.the inter ...19704246110
muscular changes in lepromatous leprosy. 19704250383
[induction with bacilli extracted from murine lepromas, of lymphoblastic transformation of lymphocytes from human lepers]. 19704252357
experimental arthus reactions using the same antigen in soluble and corpuscular form. 19714255853
[treatment of lepromatous leprosy by ethionamide]. 19724261347
mycobacterium leprae in a muscle spindle. 19724262739
effect of inorganic and organic substances containing sulfur or nitrogen and of vitamins on the growth of mycobacterium leprae. 19744278072
acid mucopolysaccharide metabolism in leprosy. 2. subcellular localization of hyaluronic acid and beta-glucuronidase in leprous infiltrates suggestive of a host-mycobacterium leprae metabolic relationship.electron- and light microscopic analyses were conducted on leprosy skin biopsies relative to the origin of hyaluronic acid, which has previously been observed to be distributed inversely in ratio to the degree of cell- mediated immunity. the present study investigated the subcellular localization of hyaluronic acid and its degrading enzyme in various types of leprosy. hyaluronic acid in some lepromatous leprosy cases was shown to be accumulated in the limiting membranes of the phagosomes of lepr ...19744282081
transmission of mycobacterium leprae to animals. nerve involvement in the ears of hamsters. 19654285970
metabolism of mycobacterium leprae separated from human leprosy nodules. 19674290018
cytological studies on host-parasite relations in experimental leprosy of mice. 19684297645
acute necrotizing lepromatous lymphadenitis: an erythema-nodosum-leprosum-like reaction in lymph nodes.histological examination of lymph-node biopsy specimens in 12 patients with erythema nodosum leprosum showed almost complete replacement of the node by lepromatous granuloma, together with considerable polymorph infiltration. ziehl-neelsen staining demonstrated numerous mycobacterium leprae present in the nodes. the majority of these patients were very ill, and responded to prednisolone or corticotrophin.it is suggested that the histological appearances may represent an intensive inflammatory re ...19684300767
unexpected high incidence of tumours in thymectomized mice treated with anti-lymphocytic globulin and mycobacterium leprae. 19694304484
effects of antilymphocytic serum on host responses to infectious agents. 19704312737
mycobacterium leprae in nerve lesions in lepromatous leprosy. an electron microscopic study. 19704313451
summary of recent abstracts. 8. leprosy. 19704321145
antibodies to mannophosphoinositides in leprosy patients. 19704324604
[leprosy research]. 19714327066
recognition of leprosy. 19734348376
implications of chemoautotrophism in mycobacterium leprae. 19734349602
immunological problems in leprosy research. 1.this memorandum reviews the present status of knowledge of the immunology of leprosy, with particular attention to developments since the publication of a similar review in 1970. the different types of lepromin reaction and their significance in healthy contacts and in patients with tuberculoid and lepromatous leprosy are discussed. the immunological responsiveness of patients with leprosy is also considered, with special attention to in vitro methods for evaluating this response. part 2 of the ...19734355402
the pathogenesis of the neuropathy in dimorphous leprosy: electron microscopic and cytochemical studies. 19744366311
peripheral nerve involvement in leprosy: quantitative histologic aspects. 19744374004
in vitro effects of some chemotherapeutic agents on mycobacteria.examination of the bactericidal and bacteriostatic effects of nine antibiotics on atypical mycobacteria revealed that streptovaricin complex and streptovaricin c exerted bactericidal effects on several strains in concentrations lower than 1.0 mug/ml. an exposure to the drug for 48 hr at 37 c was necessary to effect a complete inactivation of more than 99.9% of the exposed microorganisms. the appearance of strepto-varicin-resistant mutants was observed. however, these mutants were unstable, and r ...19674383871
[an unusual diagnosis in practitioner dermatology]. 19694389292
kinetic testing of drugs against mycobacterium leprae in mice. activity of cephaloridine, rifampin, streptovaricin, vadrine, and viomycin. 19714398128
sequential blockade of the mycobacterial de novo folate pathway. a review. 19714399473
prolongation of the lag phase of mycobacterium leprae by dapsone. 19724550215
incorporation of tritiated thymidine by leprosy bacilli in cultures of human lepromatous macrophages. 19724553085
transfer factor. 19724554090
clofazimine therapy of lepromatous leprosy caused by dapsone-resistant mycobacterium leprae. 19724554496
[chemotherapy of leprosy--effect of the anti-leprotic agent on the growth of acid-fast bacilli in cutaneous and mucous tissue]. 19724554827
the effect of rifampicin and dapsone on experimental mycobacterium leprae infections: minimum inhibitory concentrations and bactericidal action. 19724555734
the continuous bacteremia of lepromatous leprosy. 19724555967
serum lipids in leprosy. 19724557091
mycobacterium leprae: club and other forms of unknown viability. 19724558677
the death rate of mycobacterium leprae during treatment of lepromatous leprosy with acedapsone (dadds). 19724559065
rapid bactericidal effect of rifampin on mycobacterium leprae. 19724559066
histopathological study of early skin lesions in leprosy. 19724559401
immunological determination of mycobacterium leprae by means of cytoplasmic antigens.mycobacterium leprae was isolated and purified from lepromas, the spleen, and the liver of leprosy patients. an immunodiffusion analysis of the cytoplasms obtained from four lots of m. leprae and m. lepraemurium, 295 strains of different actinomycetales, and 12 other bacteria was performed with the use of the cytoplasm antisera. immunological relationships were revealed between the cytoplasms of m. leprae, m. lepraemurium, m. avium, m. gallinarum, m. tuberculosis, m. simiae, m. kansasii, m. chit ...19724559465
a test for the determination of competency in clearing bacilli in leprosy patients.a skin test has been developed to determine the degree of competency in clearing bacilli from the tissues of patients suffering from various forms of leprosy. the test involves the intradermal injection of a suspension of killed mycobacterium leprae. the response of leprosy patients to the injection of other mycobacterial antigens, one prepared from m. lepraemurium and another from an atypical mycobacterium from a hamster, was also investigated in order to study the isopathic phenomenon. since l ...19724561454
summary of recent abstracts. 8. leprosy. 19724562257
studies in the viability of mycobacterium leprae in human liver and bone marrow using thymectomized mouse foot pad technic. 19724562382
combinations of drugs against mycobacterium leprae studied in mice. 19724562383
preparation of purified suspensions of mycobacterium leprae and mycobacterium lepraemurium from biopsy material. 19724562384
cross reactivity of mycobacterium laprae and bcg. a report on further studies. 19724562385
an evaluation of transfer factor as immunotherapy for patients with lepromatous leprosy. 19724562439
recent trends in leprosy research. 19724562677
animal models for research in leprosy. 19724563001
ultrastructural changes in cells of the mouse footpad infected with mycobacterium leprae.ultrastructural changes in cells of the mouse footpad are described which occurred during the log phase of multiplication, the plateau, and the stationary phase of growth of mycobacterium leprae.balb/c mice were inoculated in the right hind footpad with 5 x 10(3) organisms and sacrificed in pairs at 86 to 173 days after inoculation. tissue samples were prepared for electron microscopy by standard techniques. during the early growth phase of m. leprae in the mouse footpad, few organisms can be de ...19724564400
adjuvant activity of mycobacterium leprae.mycobacterium leprae organisms isolated from infected spleen and liver tissue by zonal centrifugation were shown to possess adjuvant activity. histochemical examination of the footpad macrophage epithelioid granuloma showed that macrophages contained large amounts of hemosiderin after the injection of m. leprae and much smaller amounts after the injection of m. tuberculosis.19724565054
inhibition of the multiplication of mycobacterium leprae by methimazole. 19724565731
an attempt to culture mycobacterium leprae in cell-free, semisynthetic, soft agar media.this paper describes an attempt to culture m. leprae from leprous nodules, using cell-free, semisynthetic, soft agar media, and the effects of varying the incubation temperature and the composition of the basic medium, as well as of pretreating the bacterial suspensions with alkali. the identification test carried out in leprosy patients by intradermal injection of bacillary suspensions prepared from the primary cultures and third subcultures suggested that the bacterial masses that had formed i ...19724566288
evaluation of cell mediated immune responses in untreated cases of leprosy. 19724567646
[immunologic and histomorphologic features of responsiveness in patients with leprosy at different stages of treatment]. 19724569353
early response of mouse foot pads to mycobacterium laprae.the purpose of these experiments was to study the early response of mouse foot pads to mycobacterium leprae. to accomplish this, mice were inoculated in both foot pads with large and small numbers of organisms. the animals were sacrificed at intervals from 2 hr to 27 days after inoculation. the microscopical results, which utilized normal balb/c and thymectomized-irradiated b6c3f(1) mice, showed that the tissue responded first with an influx of polymorphonuclear cells and later lymphocytes and m ...19734570280
growth inhibitors and promoters acting on mycobacterium leprae. 19724570283
[leprosy as an immunological model]. 19734570661
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