Publications

[rational parameters in the treatment of bacterial meningitis with modern cephalosporins].	modern cephalosporins are by now well established therapeutic drugs in the treatment of bacterial meningitis. particularly for gram-negative meningitis they are valuable therapeutic tools. in most cases, they are very efficient and less toxic than former therapeutic regimens. of course, they cannot replace penicillin g in the therapy of meningitis with penicillin-sensitive bacteria. the advantages and disadvantages of the single compounds, cefotaxime, latamoxef, ceftizoxime, cefmenoxime, ceftazi ...	1987	3312038
chemotherapy for bacterial infections of the central nervous system.	over the past six years, many new agents have become available for the treatment of bacterial central nervous system (cns) infections. certain principles guide the use of these agents for cns infections: first, an antimicrobial agent must be able to penetrate the cns to be effective; second, the cns is a "relatively immunoincompetent site" so that an antimicrobial must achieve levels within the cns capable of killing the offending bacterium. the lack of efficacy of chloramphenicol for meningitis ...	1987	3314156
cephalosporins in the treatment of meningitis.	the synthesis of new cephalosporin antibiotics has provided agents which can effectively be used to treat most of the different forms of meningitis. none of the first generation cephalosporins can be considered acceptable as agents to treat meningitis. cefuroxime can be used to treat meningitis due to streptococcus pneumoniae, haemophilus influenzae and neisseria meningitidis in children. agents such as cefotaxime and ceftriaxone are appropriate for neonatal meningitis due to escherichia coli an ...	1987	3319497
the role of interleukin 1 and 2 in generation of acquired resistance against mouse typhoid infection afforded by dialyzable factor from salmonella typhimurium.	dialyzable factor (df) prepared from a ribosomal fraction of salmonella typhimurium was tested for its ability to induce interleukin 1 (il 1) and 2 (il 2) production, in relation to acquired resistance, after an intraperitoneal injection of df. il 1 production in vitro by peritoneal macrophages of df-treated mice reached the maximum 4 days after injection, at the time when the nonspecific local resistance via macrophages directly activated with df became apparent (kita et al, microbiol. immunol. ...	1987	3323855
[infection by listeria monocytogenes after a renal transplant. report of 6 cases].		1987	3329762
listeria monocytogenes endocarditis.		1988	3339880
listeria monocytogenes peritonitis.	listeria monocytogenes peritonitis in a patient with cirrhosis and simultaneous soft tissue infection is reported. six previously documented cases are reviewed. all seven patients were bacteremic, suggesting hematogenous seeding to the peritoneum as the pathogenic mechanism. clinical and laboratory characteristics of l. monocytogenes peritonitis are compared with peritonitis of other bacterial etiologies.	1988	3341344
antibacterial activity of recombinant murine beta interferon.	recombinant murine beta interferon was protective and therapeutic for mice against listeria monocytogenes infection in vivo. the recombinant murine beta interferon caused enhanced h2o2 release by macrophages in vivo, but not in vitro.	1988	3343048
susceptibility of hrs/j mice to listeriosis: dynamics of infection.	congenitally hairless hrs/j homozygous (hr/hr) mice as well as phenotypically normal littermates (hr/+) were found to exhibit unusual susceptibility to infection with listeria monocytogenes with 50% of the animals dying within a 10-day period (ld50) at an infecting inoculum approaching 200 microorganisms. in marked contrast to the outbred cd-1 strain as well as other listeria-susceptible mice, hrs/j hosts are virtually incapable of limiting infection with virulent listeria. the dynamics of infec ...	1988	3343051
effect of combined treatment of anti-inflammatory drug and mannoheptulose on the production of tumour necrosis factor and endotoxin shock in mice.	the endotoxin shock induced in mice by injection of viable listeria monocytogenes and challenged with endotoxin can be alleviated by combined administration of mannoheptulose with acetylsalicylate or sulindac. the ability of animals to secrete tumour necrosis factor into the blood was, however, not affected. the significance of these observations are discussed.	1988	3359411
successful surgical treatment of a case of listeria monocytogenes endocarditis.	endocarditis due to listeria monocytogenes is rare with only twenty one cases to our knowledge appearing in the world's literature to date. we report a further case with a successful surgical outcome and stress the importance of surgery in the treatment of infective endocarditis. there is a clear predilection of this organism for the left side of the heart and systemic embolization is frequent. in contrast to other clinical forms of listeriosis, endocarditis has not been associated with debilita ...	1988	3360833
tumor necrosis factor alpha in cerebrospinal fluid during bacterial, but not viral, meningitis. evaluation in murine model infections and in patients.	to evaluate the potential role of cachectin/tnf-alpha in the pathogenesis of bacterial and viral meningitis, concentrations and kinetics of tnf-alpha were determined in cerebrospinal fluid (csf). after intracerebral, but not systemic, infection with listeria monocytogenes in mice, tnf-alpha was detected as early as 3 h after infection reaching maximum titers after 24 h. however, tnf-alpha was not found in serum during the course of listeria infection. in contrast to bacterial meningitis, no tnf- ...	1988	3367098
listeria monocytogenes. a cause of unexplained death in low-risk patients?		1988	3367896
[quantitative bacteriological studies in experimentally infected laboratory animals. 4. effect of activated and inactivated immunomodulators on experimental listeria monocytogenes infections].		1988	3369916
prosthetic hip infection caused by listeria monocytogenes.		1988	3373031
effect of a high-fat diet on resistance to listeria monocytogenes.	effects of a high-fat diet on macrophage (m phi) functions were investigated. eight-week-old ddn mice were fed a high-fat diet and carbon clearance was tested. remarkable suppression of phagocytic activity (k16) was observed in mice fed such a diet for 1 or 2 weeks. resistance against listeria monocytogenes inoculated intravenously (iv) with a lethal, a sublethal, or a non-pathogenic dose was observed in the liver of mice fed a high-fat diet. when mice were infected with a lethal dose of bacteri ...	1988	3373520
in vitro activities of two oxazolidinone antimicrobial agents, dup 721 and dup 105.	the antibacterial activities of dup 105 and dup 721, new oxazolidinone antimicrobial agents, were compared with those of beta-lactams and glycopeptides. ninety percent of staphylococcus aureus and staphylococcus epidermidis isolates, including methicillin-resistant isolates, were inhibited by 4 micrograms of dup 105 and 1 microgram of dup 721 per ml. dup 721 inhibited hemolytic streptococcus groups a, b, c, f, and g at a concentration of less than or equal to 1 microgram/ml, and it inhibited vir ...	1988	3377467
listeriosis in the united states: 1980-1982.	the magnitude of the public health problem associated with listeria monocytogenes in the united states has been unknown, and the route of transmission is largely undetermined. investigations of recent outbreaks, however, have shown that the infection can be foodborne. we estimated the expected frequency of sporadic listeriosis based on hospital discharge data from the professional activity study of the commission on professional and hospital activities for the years 1980 through 1982. the incide ...	1988	3377624
perinatal listeriosis underdiagnosed as a cause of pre-term labour?	between april 1, 1985, and april 1, 1986, four cases of perinatal listeriosis were reported at the maastricht academic hospital. all cases were of the early-onset type. all mothers were admitted for pre-term labour between 28 and 33 weeks of gestation. pre-natal symptoms included maternal fever, non-characteristic influenza-like manifestations, leucocytosis and (pre-term) meconium-stained amniotic fluid. two neonates died, one in utero and one due to listeriosis sepsis. another neonate developed ...	1988	3384163
sera from patients with high titers of antibody to streptolysin o react with listeriolysin.	sera of patients with suspected rheumatic fever and elevated titers of antibody to streptolysin o were examined by an immunoblotting technique. all but two serum samples, which yielded relatively low titers, bound to a 60-kilodalton protein in the supernatant from a culture of listeria monocytogenes, which presumably represents the listeriolysin.	1988	3384901
effects of ozone on the defense to a respiratory listeria monocytogenes infection in the rat. suppression of macrophage function and cellular immunity and aggravation of histopathology in lung and liver during infection.	we have investigated the effect of exposure to ozone on defense mechanisms to a respiratory infection with listeria monocytogenes in the rat. for this purpose rats were continuously exposed to o3 concentrations ranging from 0.25 to 2.0 mg/m3 for a period of 1 week. in this model defense to a respiratory infection with listeria depends on acquired specific cellular immune responses, as well as on natural nonspecific defense mechanisms. the results confirm earlier findings that show that ozone exp ...	1988	3400093
[pathogens in neonatal infection and their resistance properties].	among 1252 consecutively treated intensive-neonatologic patients during the years 1985 to 1987 79 cases (= 6.5%) of neonatal septicemia were diagnosed by positive blood- and/or cerebrospinal fluid cultures. the relation between early onset type (up to the 4th day of life) and late onset type was 4:1. the most frequent pathogen was staphylococcus epidermidis (40% of early onset type, 56% of late onset type) followed in the case of early onset type by listeria monocytogenes (13%), streptococci (11 ...	1988	3407209
ondine's curse in listeria monocytogenes brain stem encephalitis.	a case of necrotizing brain stem encephalitis due to listeria monocytogenes is described in a 48-year-old man who had brain stem encephalitis of complicated course and with selective destruction of the vasomotoric and respiratory centers. he developed that very rare ondine's curse syndrome, being only able to breathe when awake. the literature on ondine's curse and brain stem encephalitis due to lm is reviewed. brain stem encephalitis has a mortality near 100%. the only treatment for ondine's cu ...	1988	3407390
toxic effects of benzene and benzene metabolites on mononuclear phagocytes.	benzene is a potent bone marrow toxin in animals and man. animal studies have shown that exposure to benzene can alter t lymphocyte functions and decrease the resistance of animals to listeria monocytogenes and transplanted tumor cells. mononuclear phagocytes participate in host resistance to listeria and tumor cells. the purpose of the studies presented here was to determine the effects of benzene and benzene metabolites on macrophage functions and the ability of macrophages to be activated for ...	1988	3422522
an in-vitro comparison of the intraphagocytic bioactivity of erythromycin and roxithromycin.	the binding to human polymorphonuclear leucocytes and the intracellular bioactivity of the macrolide antibiotics erythromycin and roxithromycin on legionella micdadei, listeria monocytogenes and staphylococcus aureus were investigated in vitro by the combination of a fluorochrome microassay and a radioassay. polymorphs with intact or absent membrane-associated oxidative metabolism were used to investigate the interactions which may occur between the intrinsic oxygen-dependent antimicrobial syste ...	1987	3429387
[clinical and therapeutic observations on meningitis caused by listeria monocytogenes].		1987	3431206
remote effects of inflammation on non-specific immunity.	following inflammation induced in mice with non-biodegradable, non-diffusible, and non-antigenic substances, host resistance is increased against bacteria, parasites and malignant cells injected at a distance from the inflammatory focus. this resistance is also increased in germ-free and nude mice. the increased resistance is correlated with (1) an increased leukopoiesis induced, at least in part, by a protein (mw = 40 kda, pi = 5.2) which, in vitro, is able to induce the differentiation of bone ...	1987	3443469
ci-934, a new difluoroquinolone: in vitro antibacterial activity and proposed disk diffusion test interpretive criteria.	the susceptibility of 7,763 clinical isolates at four medical centers to ci-934 and three comparative quinolones was tested. ci-934 was the most active compound against gram-positive isolates, such as staphylococci (mic 90 = 0.25 microgram/ml), and enterococci (mic 90 = 0.5 microgram/ml). ci-934 was the least active of these drugs against pseudomonas spp. (mic 90 = greater than 8.0 micrograms/ml). against all other organisms ci-934 was very effective, being most comparable with enoxacin. with a ...	1987	3471371
in vitro activity of ci-934 compared with ciprofloxacin, enoxacin, norfloxacin, and vancomycin.	the in vitro activity of the quinolone ci-934 was compared with ciprofloxacin, norfloxacin, enoxacin, and vancomycin against 607 gram-positive and -negative isolates. ci-934 inhibited 90% of the enterobacteriaceae, aeromonas hydrophila, and acinetobacter spp. at 1 microgram/ml. decreased activity was observed against pseudomonas aeruginosa. pseudomonas maltophilia, and other pseudomonas spp. with ci-934 mic90 greater than or equal to 8 micrograms/ml. ci-934 activity against gram-positive organis ...	1987	3472704
comparative in vitro activities of pefloxacin, ofloxacin, enoxacin and ciprofloxacin against 256 clinical isolates.	the antibacterial activity of four new fluoroquinolone carboxylic acids, pefloxacin, ofloxacin, enoxacin and ciprofloxacin, against 256 clinical isolates was investigated by means of an agar dilution method. generally, all quinolones tested had a high activity against gram-negative bacteria. more than 90% of enterobacteriaceae strains were inhibited by a quinolone concentration of 0.4 microgram/ml. also strains usually resistant to conventional beta-lactam antibiotics, and sometimes to third-gen ...	1987	3473910
[listeria monocytogenes infection in children].	listeria monocytogenes infection is relatively unusual in children. two cases are reported which illustrate that meningitis and septicemia are the most frequent manifestations at this age. prognosis is especially bad in immunodeficient patients.	1987	3476024
bacteremia and fungemia in patients with the acquired immunodeficiency syndrome.	forty-nine episodes of bacteremia and fungemia occurred in 38 of 336 patients with the acquired immunodeficiency syndrome seen at our institution since 1980. there were five types of infections. infections commonly associated with a t-cell immunodeficiency disorder comprised 16 episodes and included those with salmonella species, listeria monocytogenes, cryptococcus neoformans, and histoplasma capsulatum. infections commonly associated with a b-cell immunodeficiency disorder included those with ...	1986	3485396
effect of cyclosporin a on immunity to listeria monocytogenes.	the effect of the immunosuppressive drug cyclosporin a (cs-a) on immunity to the facultative intracellular bacterium listeria monocytogenes was investigated in unprimed and primed mice. different treatment protocols were followed to evaluate the time dependence of cs-a-mediated immune suppression and the effect of cs-a on immunological memory to l. monocytogenes. the effect of cs-a was observed only during and after activation of t cell-mediated immunity, whereas early resistance exerted by macr ...	1986	3485573
cyclosporine inhibits macrophage-mediated antigen presentation.	the influence of cyclosporine on antigen-specific, macrophage-dependent t cell activation was analyzed in vitro. murine t cell activation by antigens derived from listeria monocytogenes was monitored by the production of interleukin 2. pretreatment (2 hr, 37 degrees c) of macrophages with cyclosporine resulted in a cell population with a markedly diminished capacity to support the activation of t lymphocytes. when cyclosporine-pretreated macrophages were added to cultures of untreated t cells an ...	1986	3486899
the relative difference in anti-listeria resistance of c57bl/6 and a/j mice is not eliminated by active immunization or by transfer of listeria-immune t cells.	in this study, we examined the effects of active and adoptive immunization on the anti-listeria resistance of innately resistant c57bl/6 and innately susceptible a/j mice. although active immunization with a sublethal dose of viable listeria monocytogenes markedly enhanced the anti-listeria resistance of both c57bl/6 and a/j mice, the 100-fold difference between the two strains in innate anti-listeria resistance was not diminished. following immunization with an equivalent sublethal dose (0.1 ld ...	1986	3488261
colony-forming cells and colony-stimulating activity during listeriosis in genetically resistant or susceptible mice.	serum colony-forming activity (csa) and colony-forming cells (cfc) of resistant (c57bl/10 scsn) and susceptible (balb/cj) mice were studied during listeria monocytogenes infection. key findings were also checked in susceptible cba/h mice. prompt, bacterial dose-dependent increases in serum csa were observed in all mice following infection. in response to the same challenge dose, serum csa increased more in susceptible mice, possibly because rapid bacterial proliferation lead to high bacterial nu ...	1986	3488827
effect of acute nutritional deprivation on macrophage colony-stimulating factor and macrophage progenitor cells in mice.	the effect of short-term nutritional deprivation on host defenses and on the parameters of macrophage production was determined in outbred mice. confirming previous data from this laboratory, initial experiments demonstrated that starved mice were relatively resistant to infection by listeria monocytogenes as determined by spleen and liver bacterial counts. the number of macrophage progenitor cells in bone marrow rose slightly during a 72-h starvation period and returned to normal during refeedi ...	1986	3489677
antigen-specific lyt-2+ cytolytic t lymphocytes from mice infected with the intracellular bacterium listeria monocytogenes.	in vitro expanded t cell lines were used to determine whether antigen-specific cytolytic t lymphocytes are generated after infection with the intracellular bacterium, listeria monocytogenes. spleen cells from infected mice were cultured in the presence of syngeneic accessory cells, listerial antigen, and interleukin 2 containing supernatants. cell lines were greater than 98% thy-1+, l3t4-, lyt-2+. bone-marrow macrophages were used as target cells in two in vitro cytolytic assay systems. the lyt- ...	1986	3489772
in vitro activity and beta-lactamase stability of two oral cephalosporins, ceftetrame (ro 19-5247) and cefetamet (ro 15-8074).	ceftetrame (ro 19-5247) and cefetamet (ro 15-8074), two new orally administered aminothiazolyl imimomethoxy cephalosporins, inhibited hemolytic streptococci and streptococcus pneumoniae at less than or equal to 0.5 micrograms/ml but were less active against staphylococci than were cephalexin and cefaclor. they did not inhibit s. faecalis, s. faecium, listeria monocytogenes, corynebacterium jk species, or pseudomonas aeruginosa. haemophilus influenzae, branhamella catarrhalis, and neisseria gonor ...	1986	3490827
listeria monocytogenes meningitis treated with trimethoprim-sulfamethoxazole.		1986	3491979
parasite accessory cell interactions in murine leishmaniasis. i. evasion and stimulus-dependent suppression of the macrophage interleukin 1 response by leishmania donovani.	interleukin 1 (il 1) is a principal mediator of the host immune response to microbial challenge. accessory cells of the monocyte-macrophage series are a major source of this cytokine and are also chronically parasitized by protozoa of the genus leishmania. this suggests that characterization of the macrophage il 1 response to leishmania would increase our understanding of the regulation of host immunity to these organisms. in the present study, the macrophage il 1 response to leishmania donovani ...	1987	3493291
the effects of an anti-i-ab antibody on murine host resistance to listeria monocytogenes.	infection with listeria monocytogenes stimulates t cell proliferation and t cell-derived lymphokine production. the release of lymphokines, in turn, "activates" macrophages, enhancing their bactericidal capacity. because prior studies suggest that i-a+ accessory cells play a critical role in this pathway, we assessed the effects of an anti-i-a antibody on the murine host resistance to listerial infection. to this end, we infused listeria into control c57bl/6 mice (i-ab haplotype) and mice of the ...	1987	3494082
comparative antibacterial activity of a new oral cephalosporin, bmy-28100.	bmy-28100 is a new oral cephalosporin which had in vitro activity superior to that of cephalexin and cefaclor against staphylococci, beta-hemolytic streptococcal species, and streptococcus pneumoniae. it inhibited beta-lactamase-producing haemophilus influenzae, neisseria gonorrhoeae, 50% of streptococcus faecalis isolates, listeria monocytogenes, and 50 to 75% of escherichia coli and klebsiella species at less than or equal to 8 micrograms/ml, but high producers of beta-lactamase were resistant ...	1987	3495236
differential protein synthesis by murine peritoneal macrophages elicited by various stimuli.	protein synthetic patterns of murine peritoneal macrophages were analyzed by two-dimensional polyacrylamide gel electrophoresis (2d page) of 35s methionine-labeled proteins. while the protein synthetic patterns exhibited by resident, inflammatory, and activated macrophages had numerous common features that distinguished them from the other normal non-macrophage cell types examined, unique proteins also characterized each macrophage population from the others. the accumulation by resident macroph ...	1987	3496410
recombinant murine interleukin-1 alpha enhancement of nonspecific antibacterial resistance.	in this study we report that treatment with recombinant murine interleukin-1 alpha (ril-1 alpha) significantly enhanced the resistance of mice to infection by the facultative intracellular pathogen listeria monocytogenes. the greatest level of protection was observed at a dose of 1,000 lymphocyte-activating factor units (approximately 0.17 micrograms) of ril-1 alpha per mouse. although ril-1 alpha enhanced antibacterial resistance when administered either intravenously or intraperitoneally, grea ...	1987	3497878
passive transfer of acquired resistance to listeria monocytogenes infection is independent of mononuclear cell granuloma formation.	this study documents the formation of leukocyte foci in the livers of mice infused with either normal or immune t cells and then challenged intravenously with listeria monocytogenes. the results show that the transfer of antilisterial resistance occurred before mononuclear cell granuloma formation and was associated instead with the appearance of foci of infiltrating lymphocytes and neutrophils. numbers of these foci remained low in mice which received immune cells but increased progressively un ...	1987	3500132
augmented nonspecific resistance and simultaneous impairment of specific immunity to listeria monocytogenes in tumor-bearing mice.	meth a tumor-bearing mice were examined for changes in the host defense mechanism against infection with listeria monocytogenes. the resistance of tumor-bearing mice to systemic, i.e., intravenous, infection in an early phase of the infection was suppressed for 1-3 days after tumor implantation (5 x 10(5) cells/mouse, subcutaneously), but was augmented thereafter even on the 35th day as compared with normal mice. suppression and enhancement of the resistance of tumor-bearing mice to primary infe ...	1987	3501807
abilities of human oligodendroglial cells and mouse schwann cells to phagocytose mycobacterium leprae and other mycobacteria.	human oligodendroglial kg-1-c cells derived from human cerebral mixed glioma and mouse schwann cells derived from dorsal root ganglion were studied with respect to their abilities to phagocytose various mycobacteria, especially mycobacterium leprae, and other microorganisms. kg-1-c cells phagocytosed m. leprae at a markedly higher rate than balb/3t3, bhk 21, hela s3, mks-a tu-7, xc, tsv-5, n-18, and schwann cells but at a lower rate than peritoneal macrophages. schwann cells also exhibited subst ...	1986	3510165
effects of suramin on the in vivo antimicrobial resistance against listeria monocytogenes and mycobacterium bovis (bcg) in mice.	following one intraperitoneal injection of suramin (400 mg/kg) in mice, biphasic alterations of the resistance to listeria monocytogenes were observed, depending on the timing of the drug administration in relation to the intravenous challenge. treatment with suramin, concomitantly or 1 day before, enhanced markedly the bacterial growth in spleen and liver, detected as early as 3 to 6 h after the challenge, the maximum being observed at 48 h in the liver. in contrast, an increased resistance was ...	1986	3514011
treatment of listeria monocytogenes infection with trimethoprim-sulfamethoxazole: case report and review of the literature.	a 55-year-old female recipient of an orthotopic liver transplant, who was receiving azathioprine, prednisone and cyclosporin, developed bacteremia due to listeria monocytogenes. because of a penicillin allergy, the patient was treated primarily with trimethoprim-sulfamethoxazole, to which she responded well. the prior literature on use of trimethoprim-sulfamethoxazole in listeria infections is reviewed, and future recommendations are considered. on the basis of the experience described in this c ...	1986	3523699
macrophage suppression by a low-molecular-weight fraction of murine spleen cell culture supernatant.	macrophage suppression has been reported to be mediated by a component of murine serum. the present investigation involves in vitro production of this macrophage modulator (suppressor) by concanavalin a-stimulated murine spleen cells. spleen cell culture supernatant containing this suppressor, which has been called macrophage suppressor factor (msf), caused a significant decrease in in vitro phagocytosis of listeria monocytogenes by resident murine peritoneal macrophages. the molecular weight of ...	1986	3527448
increased phagocytic activity in mice treated by a mouse granuloma protein.	intravenous injection of a protein extracted from a talc-induced granuloma (mgp) enhanced the blood clearance of a highly virulent strain of salmonella typhimurium. this protein was able to enhance mouse resistance to systemic infection with listeria monocytogenes when injected one or two days prior to infection. furthermore, since mgp-treated athymic mice were also protected against listeria infection, mature t cells were most likely not involved in this enhanced resistance. these findings sugg ...	1986	3530114
immunotoxicity studies in mice exposed to methyl isocyanate.	the effects of methyl isocyanate (mic) on systemic immunity were evaluated in female b6c3f1 mice exposed via inhalation to 0, 1, or 3 ppm for 6 hr per day on four consecutive days. humoral immunity, measured as the antibody response to sheep erythrocytes, and natural killer cell activity were not affected by mic. furthermore, resistance to the infectious agents listeria monocytogenes, mouse malaria parasite, and influenza virus, or to b16f10 transplantable tumor cells, was not compromised by mic ...	1986	3532429
complement split product c5a mediates the lipopolysaccharide-induced mobilization of cfu-s and haemopoietic progenitor cells, but not the mobilization induced by proteolytic enzymes.	intravenous (i.v.) injection of mice with lipopolysaccharide (lps), and the proteolytic enzymes trypsin and proteinase, mobilizes pluripotent haemopoietic stem cells (cfu-s) as well as granulocyte-macrophage progenitor cells (gm-cfu) and the early progenitors of the erythroid lineage (e-bfu) from the haemopoietic tissues into the peripheral blood. we investigated the involvement of the complement (c) system in this process. it appeared that the early mobilization induced by lps and other activat ...	1986	3533267
bacterial meningitis in infants two to six weeks old.	we reviewed our experience with bacterial meningitis in older neonates (2 to 6 weeks of age) during a five-year period. seventeen patients with bacterial meningitis were diagnosed and treated. bacteria recovered from the cerebral spinal fluid (csf) included pneumococci (29%), e. coli and meningococci (23% each), group b streptococci (12%), enterobacter and h. influenzae (6% each). there were no cases of listeria monocytogenes. the mean duration of symptoms before admission was 3.1 days. the mort ...	1986	3539885
in vitro activity of ciprofloxacin against gram-positive bacteria. an overview.	a review of european data published before july 1986 and data from the authors' laboratory showed very similar activity of ciprofloxacin against gram-positive bacteria in all studies. mean minimal inhibitory concentrations against 50 percent (mic50) and 90 percent (mic90) of staphylococcal strains were 0.32 and 0.59 mg/liter, respectively. the drug was equally active against staphylococcal strains resistant and susceptible to methicillin and/or gentamicin. the range of mic50 and mic90 values for ...	1987	3555058
differential growth of legionella pneumophila in guinea pig versus mouse macrophage cultures.	legionella pneumophila is a facultative intracellular bacterium which replicated well in inbred guinea pig strain 2 peritoneal macrophages at a low infectivity ratio. in contrast, the growth of this organism was markedly restricted in mouse (bdf1) peritoneal macrophages, even at a relatively high infectivity ratio. the initial uptake of l. pneumophila organisms by macrophages was similar in both animal species, and both groups of macrophages supported the growth of listeria monocytogenes. treatm ...	1987	3570468
lack of synergism of ampicillin and gentamicin in experimental listeriosis.	strain slcc 4013 of listeria monocytogenes is susceptible in vitro to ampicillin (mic 0.5 mg/l) as well as to gentamicin (mic 0.5 mg/l). whereas treatment of mice infected with this virulent strain with 0.5 mg ampicillin twice a day resulted in a marked decrease in bacterial counts per spleen, the administration of 2 mg gentamicin twice a day hardly reduced bacterial multiplication. the combination of both drugs was not much more effective than ampicillin alone. thus, a synergistic effect of bot ...	1987	3570481
transient immunologic defect in a case of listeria rhombencephalitis.	we report a case of listeria rhombencephalitis in a previously healthy 60-year-old man. listeria rhombencephalitis is a rare but well-defined clinical syndrome of lower brain-stem involvement caused by listeria monocytogenes. contrary to other listerioses, rhombencephalitis has been mainly observed in patients without predisposing conditions. in our case, however, findings of a detailed immunologic study, performed three months and one year, respectively, after clinical onset of listeria rhomben ...	1987	3579687
[septicemia caused by listeria monocytogenes in the adult].		1987	3586746
immunomodulatory effect of listeria monocytogenes infection. iii. expression of fc receptor and antibody-mediated cytotoxicity in infected mice.	the level of cells expressing fc receptor and their ability to antibody mediated cytotoxicity was determined in this study. the adherent cells fraction isolated from blood leukocytes, splenocytes and peritoneal cells of listeria monocytogenes infected balb/c mice were rosetted with ab-srbc or srbc. moreover, blood leukocytes, splenocytes and peritoneal cells were incubated with ab-51cr srbc and 51cr srbc as target cells and their cytotoxic activity was assessed by the per cent of specific 51cr r ...	1986	3592939
enhancement of immunostimulating and immunotherapeutic effect of bcg vaccines using listerial endotoxin-like substances.	on the basis of experience with the immunomodulating effect of the endotoxin-like component of listeria monocytogenes, designated factor ei, the time parameters concerning the onset and duration of hypersensitivity induced by listeriae, mycobacteria and their components were compared. their differences, just like different mechanism of their effect, following their simultaneous and repeated administration, furnish means of significantly enhancing the anti-tuberculosis and anti-tumor effect of st ...	1986	3596044
modulation of cell-mediated resistance to listeriosis in mice given t-2 toxin.	the modulating effect of preinoculation and postinoculation treatment with a single oral 4.0 mg/kg dosage of t-2 toxin on cell-mediated resistance was studied in mice inoculated with listeria monocytogenes. toxin treatment caused significant decreases in thymus and spleen weights, bone marrow cellularity, and in the total number of circulating leukocytes, lymphocytes, and neutrophils. enhancement or suppression of resistance to listeriosis was dependent on the time of toxin administration relati ...	1987	3603564
listeria monocytogenes infection and hairy cell leukemia.		1987	3605174
corneal ulcer due to listeria monocytogenes.	we present a patient with a corneal ulcer due to listeria monocytogenes, which has not previously been considered to be a feature of human listeriosis. the ulcer responded to topical and subconjunctival gentamicin and cephaloridine. subsequent management was complicated by the development of a fibrinous pupillary membrane leading to pupillary block requiring iridotomy and later vitrectomy with trabeculectomy. listeria monocytogenes may be confused with diphtheroid contaminants seen in corneal ul ...	1987	3608514
[recent trend of childhood bacterial meningitis in japan (1979-1984). part 4. a classification of prognosis and antibiotic treatment based on causative agents].	nine hundred seventy cases of childhood bacterial meningitis treated at 107 institutions in japan from 1979 through 1984 were studied using questionnaire. the number of cases that underwent antimicrobial monotherapy remained nearly constant during the study period, but cases of therapies with beta-lactam combined with aminoglycosides (ags) decreased in number and a gradual increase in the use of beta-lactam combined with non-ags antibiotics including beta-lactam (non ags) was observed. a trend s ...	1987	3613093
comparative in vitro activity of ci934, a new fluoroquinolone, alone and in combination with coumermycin, against gram-positive bacteria.	the in vitro activity of cl934, a new quinolone antimicrobial agent, was studied against 314 strains of gram-positive bacteria representing 6 genera: staphylococcus aureus, streptococcus faecalis, s. agalactiae, s. pyogenes, s. pneumoniae, s. milleri, viridans streptococci, listeria monocytogenes, corynebacterium jk, mycobacterium fortuitum and bacillus spp.; and compared with that of enoxacin, ciprofloxacin, penicillin g, ampicillin, coumermycin, oxacillin, vancomycin, teicoplanin, rifampin, ri ...	1987	3622241
in vitro evaluation of the new paulomycin antibiotic paldimycin.	the comparative in vitro activity of paldimycin, a new antibiotic, was evaluated against 215 gram-positive bacteria. activity of the compound was greater in nutrient agar of ph 6.8 than in mueller-hinton agar. all strains of staphylococci, streptococci, enterococci and listeria monocytogenes were inhibited at concentrations less than or equal to 2 micrograms/ml. activity of the new drug was generally comparable to that of vancomycin.	1987	3622497
mri of listeria rhombencephalitis.	a case of listeria rhombencephalitis in a patient, who was evaluated by mri, is reported. mri showed areas of high signal intensity on t2-weighted images in the rhombencephalon and confirmed the clinical diagnosis of a brainstem affection by listeria monocytogenes.	1987	3627425
endotoxin shock and tumour necrosis factor release in mannoheptulose-treated mice.	administration of mannoheptulose partially protected mice infected with listeria monocytogenes against the lethal effect of a subsequent endotoxin challenge. the ability of these animals to produce tumour necrosis factor was however unaffected. mannoheptulose was observed to reverse the hypoglycaemic effect of endotoxin, possibly through inhibition of insulin secretion. the therapeutic significance of these observations is discussed.	1987	3664450
clinical manifestations of epidemic neonatal listeriosis.	we report the broad spectrum of clinical manifestations in 23 infants with positive cultures for listeria monocytogenes who were treated in our hospital during a recent epidemic. the majority of infants (70%) were preterm and none was small for gestational age. thirteen (56%) had respiratory distress at birth with evidence of congenital pneumonia. four of the 5 deaths occurred among these infants. four infants considered healthy after resuscitation developed fever and lethargy within 36 hours af ...	1987	3670948
[listeria monocytogenes spontaneous peritonitis of the cirrhotic patient].		1987	3671852
arterial occlusion due to listeria meningoencephalitis in an immunocompromised boy.	sequential cat scan studies of the brain were performed in a 7-year-old boy with listeria monocytogenes serotype 1 meningoencephalitis. the infection occurred while he was receiving maintenance chemotherapy for t-cell non-hodgkin lymphoma. a lesion in the right hemisphere during the infection resulted in an excessive enlargement of the right ventricle 10 months later, most probably caused by arterial occlusion.	1987	3672054
listeriosis in diacetoxyscirpenol-treated mice.	mice were treated with the trichothecene mycotoxin diacetoxyscirpenol (das) and subsequently were inoculated intraperitoneally with listeria monocytogenes. the effect of the mycotoxin on the course of the infection was monitored by observing the resultant mortality and the bacterial content of the spleens from inoculated mice. mice given 3 mg of das/kg of body weight, po, at days -2 and -1 before inoculation had increased mortality and splenic listeria counts. in these mice, thymus weights were ...	1987	3674563
listeria monocytogenes infection with rhombencephalitis.		1987	3681320
t-2 toxin effects on the serum amyloid p-component (sap) response of listeria monocytogenes- and salmonella typhimurium-infected mice.	t-2 mycotoxin, given to mice 4 days prior to an intraperitoneal inoculation with listeria monocytogenes egd, increases the acute phase response as determined by measurements of serum amyloid protein-p (sap), and decreases the severity of the infection. conversely, when t-2 toxin is given simultaneously with l. monocytogenes the mice become more susceptible to the infection, and the sap levels attained are diminished relative to the non-toxin-treated listeria-infected controls. t-2 toxin given 4 ...	1987	3686547
the pathologic and immunologic effects of inhaled acrolein in rats.	four groups of 40 male sprague-dawley rats each were exposed by inhalation to target concentrations of 0, 0.1, 1.0, and 3.0 ppm of acrolein 6 h/day, 5 days/week for 3 weeks. subsequent changes in local pulmonary immunity were determined by examining the number of antibody plaque-forming cells in the lung-associated lymph nodes following intratracheal immunization with sheep red blood cells. separate groups of rats were evaluated for blastogenic responsiveness to phytohemagglutinin-p and salmonel ...	1987	3686549
production of tumor necrosis factor during murine listeriosis.	during a lethal murine infection with the gram-positive bacterium, listeria monocytogenes, a factor appears in the serum that is capable of lysing certain tumor cells in vitro. the levels of this serum cytotoxic factor increase with the progression of morbidity. neutralization of listeria-induced cytotoxic factor activity with a monospecific antiserum to recombinant murine tumor necrosis factor (tnf) revealed that the cytotoxic factor was antigenically indistinguishable from natural tnf present ...	1987	3693903
[meningitis caused by listeria monocytogenes: a rare complication of cushing's syndrome].		1987	3695691
in-vitro activity of ru 28965, a new macrolide, compared to that of erythromycin.	the activity of a novel macrolide, ru 28965, was compared to that of erythromycin against gram-positive organisms isolated mainly from cancer patients. ru 28965 was active against streptococci including streptococcus pneumoniae and streptococcal groups a, b and g. it was also active against methicillin-susceptible staphylococci, bacillus cereus and listeria monocytogenes. its activity against these organisms was generally equal to that of erythromycin. ru 28965 was moderately active against ente ...	1986	3700283
an unusual case of cutaneous listeriosis.	listeria monocytogenes was identified as the etiological agent in the cutaneous and febrile illness of a 64-year-old male who acquired the organism as a result of contact with the genital tract of a cow while assisting in the delivery of a stillborn calf.	1986	3711288
[listeria monocytogenes meningitis in the adult. study of 10 cases].		1986	3715117
listeria monocytogenes meningitis in aids.		1986	3719486
[infections of the central nervous system in malignant hemopathies].	central nervous system (cns) infections in immunocompromised hosts are often accompanied by subtle disorders because immunosuppression usually decreases the inflammatory response. cns infections in immunocompromised patients are usually caused by organisms different from those found in the general population. the organism causing cns infection in an immunocompromised host can often be predicted if the type of immune abnormality of the patient is known. the common causes of cns infection in immun ...	1986	3726388
listeria monocytogenes endocarditis in a patient on chronic hemodialysis, successfully treated with vancomycin-gentamicin.	a case of listeria monocytogenes endocarditis occurring as a complication of a vascular access infection in a patient on chronic hemodialysis that was successfully treated with a combination of vancomycin and gentamicin is reported. the difficulties in the diagnosis and treatment of l. monocytogenes infections, especially endocarditis, in patients on chronic hemodialysis are discussed.	1986	3733226
rhombencephalitis by listeria monocytogenes: onset of symptoms two days after perianal injections.		1986	3733228
fatal listeria monocytogenes meningitis in two previously healthy adults.		1986	3739064
experimental infection of pregnant ewes with listeria monocytogenes.	eight 18-month-old ewes were infected orally with listeria monocytogenes between 77 and 91 days of pregnancy. only one ewe aborted, 10 days after the first infecting dose, at 94 days of gestation; l monocytogenes was isolated from several sites in both its aborted fetuses. two days after the first infecting dose all the ewes exhibited mild illness and pyrexia lasting for two to three days but the ewe which aborted was seriously ill until nine to 10 days after aborting. agglutination tests carrie ...	1986	3739142
listeria monocytogenes: a rare cause of opportunistic infection in the acquired immunodeficiency syndrome (aids) and a new cause of meningitis in aids. a case report.	a forty-two year-old male homosexual with the acquired immunodeficiency syndrome (aids) developed listeria monocytogenes septicemia and meningitis. the gastrointestinal tract was the likely portal of entry. the patient was treated with intravenous ampicillin with complete and permanent resolution of his listerial infection. although l. monocytogenes infection has been reported as an uncommon complications of aids, we are unaware of listeria meningitis being previously reported in an aids patient ...	1986	3755910
oxidative and phagocytic functions of macrophages during infections induced in mice by mycobacterium intracellulare and listeria monocytogenes.	the oxidative metabolism (chemiluminescence and h2o2 release) and phagocytic activity of mouse peritoneal macrophages during chronic infections induced by mycobacterium intracellulare and more acute infections due to listeria monocytogenes were studied. in m. intracellulare infections, macrophage chemiluminescence in response to phorbol myristate acetate (pma) was greatest at around 2 weeks, with a 1 week lag phase after infection, while the pma-triggered h2o2 release was markedly enhanced even ...	1986	3760821
perinatal listeriosis (early-onset): correlation of antenatal manifestations and neonatal outcome.	listeria monocytogenes is an underdiagnosed and underreported cause of congenital sepsis. twenty mother/infant pairs from whom listeria was isolated were studied at the university of southern california school of medicine and women's hospital during the last ten years to delineate antepartum factors indicative of a fetus at high risk for perinatal listeria sepsis. the combination of high maternal leukocyte count, fetal tachycardia, decreased fetal heart rate variability, and, especially, the abs ...	1986	3763068
immunotoxic effects of t-2 toxin on cell-mediated immunity to listeriosis in mice: comparison with cyclophosphamide.	immunotoxic effects of t-2 toxin and cyclophosphamide on cell-mediated resistance were evaluated in mice exposed to listeria monocytogenes infection. mice were inoculated intraperitoneally with 4.0 x 10(5) (ld50) or 4.0 x 10(4) (nonlethal) l monocytogenes and were treated with 4.0 mg of t-2 toxin/kg of body weight or 180 mg of cyclophosphamide/kg. the immunosuppressive effect of the toxin and cyclophosphamide was indicated by the rapid growth of listeria and significant (p less than 0.005) incre ...	1986	3767103
toxicity and induction of resistance to listeria monocytogenes infection by amphotericin b in inbred strains of mice.	amphotericin b (amb) treatment before infection with the bacterium listeria monocytogenes prolonged survival of akr mice but shortened survival of c57bl/6 mice compared with survival of untreated infected controls. c57bl/6 mice were also more sensitive to the acute toxic effects of amb than akr mice, as were (c57bl/6 x akr)f1 hybrid mice. spleen cells and erythrocytes (rbcs) from the c57bl/6 and the f1 hybrid mice were both more sensitive to the lytic and lethal effects of amb than corresponding ...	1986	3770945
[results of a national survey on the antibiotic therapy of neonatal bacterial infection due to materno-fetal contamination].	the aim of the study was to overview the antibiotic treatments usually prescribed in the different neonatal units and nicu's for neonatal primary bacterial infections. maternal or neonatal fever, shock, respiratory distress, leuconeutropenia, hyperfibrinemia as well as an increased level in c-reactive protein appeared to be the best clinical diagnosis criteria. before isolation of the bacteria, the most frequently prescribed treatment was a combination of ampicillin and gentamicin. when no bacte ...	1986	3774424
[epidemiologic study of human listeriosis in france, 1984].	to estimate the incidence rate of listeriosis in france during one year, a census of all the isolates of listeria monocytogenes was made in 1984 by the microbiologists of 78% of the french hospitals. 630 cases of listeriosis were registered giving a yearly incidence rate of 11.3 cases for 1 million inhabitants. 353 cases (56%) were perinatal listeriosis (positive cultures for l. monocytogenes from the mother, the child or the placenta). compared with earlier data, listeriosis seems to be more fr ...	1986	3786876
epidemic perinatal listeriosis at autopsy.	seven cases of listeriosis identified at perinatal autopsy are described. the cases occurred during the time of a 1985 los angeles, california, epidemic of listeriosis from suspected food contamination by listeria monocytogenes. in only one of seven cases were gross pathologic lesions encountered. microscopic lesions in six cases consisted of rare, localized microabscesses or granuloma-like lesions in multiple organs and contained histiocytes, monocytes, lymphocytes, and polymorphonuclear leukoc ...	1986	3793087
immune protective mechanisms during pregnancy. i. cell-mediated immunity against listeria monocytogenes in pregnant mice.	characteristics of protective mechanisms during pregnancy were investigated using neonatally thymectomized (ntx) and/or pregnant mice infected with sublethal doses of listeria monocytogenes, of which the explosive growth at an early phase of 2 or 3 days after infection is prevented by non-immune macrophages, and complete elimination at a late phase from 4 to 10 days after infection is attributed to the augmented functions of macrophages in co-operation with lymphokine-producing sensitized t lymp ...	1986	3793136
nonneonatal relapsing meningitis caused by listeria monocytogenes.		1986	3797313
listeria monocytogenes cerebritis, bacteremia, and cutaneous lesions complicating hairy cell leukemia.	hairy cell leukemia is a lymphoreticular malignancy characterized by a chronic course and multiple defects in host defense mechanisms. infections are the major cause of morbidity and mortality in this malignancy. opportunistic infections due to pathogens normally controlled by cell-mediated immune mechanisms have been increasingly described but have not included listerial infections. this report describes a case of disseminated listeria monocytogenes infection including the uncommon manifestatio ...	1986	3799637
listeria monocytogenes and the acquired immunodeficiency syndrome.		1987	3800521