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clinical testing of thermally stimulated cardiovascular oscillations in man.the study assessed the physiological validity of an automatic thermal stimulation method to induce synchronised oscillations in the neural cardiovascular control system.19911913758
[specifics in the experience of childbirth via cesarean section]. 20071913867
cloning, sequencing, and expression of the p-protein gene (phea) of pseudomonas stutzeri in escherichia coli: implications for evolutionary relationships in phenylalanine biosynthesis.the phea gene encoding the bifunctional p-protein (chorismate mutase:prephenate dehydratase) was cloned from pseudomonas stutzeri and sequenced. this is the first gene of phenylalanine biosynthesis to be cloned and sequenced from pseudomonas. the phea gene was expressed in escherichia coli, allowing complementation of an e. coli phea auxotroph. the enzymic and physical properties of the p-protein from a recombinant e. coli auxotroph expressing the phea gene were identical to those of the native ...19911919506
experimental infection of domestic ferrets (mustela putorius furo) and siberian polecats (mustela eversmanni) with yersinia pestis.eight domestic ferrets (mustela putorius furo) and two siberian polecats (m. eversmanni) were inoculated subcutaneously with 12 to 1.2 x 10(7) yersinia pestis originally isolated during an epizootic of plague in white-tailed prairie dogs (cynomys leucurus) near meeteetse, park county, wyoming (usa) in 1985. none of the ferrets or polecats developed clinical signs of disease which suggested that black-footed ferrets (m. nigripes), a congener, also would be resistant to plague. all animals receivi ...19911920664
[the effect of extradurally administered analgesics on somatosensory evoked eyelid microvibration in rabbits].we examined the effect of various analgesics administered lumboextradurally or intravenously on acceleration of the eyelid microvibration (emv) due to reflex contraction which was evoked by electrical stimulation of the sciatic and ulnar nerve in rabbits. no significant difference in the inhibition of emv was observed initially between the sciatic nerve and the ulnar nerve stimulated group after 2 mg of morphine, administered either extradurally or intravenously. however, greater inhibition of e ...19911920786
report of the ipsm working party on low- and medium-energy x-ray dosimetry. institute of physical sciences in medicine.new values of the factors required to convert the reading of a radiation dosemeter calibrated in terms of air kerma (or exposure) into absorbed dose to water for medium-energy x-radiation were given in a code of practice published by the iaea in 1987. these are not considered to possess sufficient support from other sources. it is therefore recommended that the f-factors given in icru report 23, and incorporated into the current hpa code of practice (1983), should continue to be used. values of ...20071924540
renal damage in mice after sequential cisplatin and irradiation: the influence of prior irradiation on platinum elimination.doses of 4-6 mg kg-1 c-ddp given 6 months before renal irradiation caused only a modest increase in functional radiation damage (def 1.1). these effects could be explained by additive toxicities and the damage was much less than when c-ddp was given 3-6 months after irradiation. pharmacokinetic studies did not demonstrate any decrease in the rate of platinum elimination after previous low-dose renal irradiation.20071924867
[fibrous hamartoma in infancy and childhood: study of 3 cases, one of them with multiple lesions].we present three cases of fibrous hamartoma of infancy, a pediatric benign fibrous proliferation. the patients were two females (10 months and 6 and half years old) and one male (18 months old). the location was characteristic in two cases: axillae and the fore aspect of the chest wall; the other case corresponds to three separated lesions located at the pubic region. the tumoral diameters were between 0.5 and 3.5 cms. two of the five tumors were adhered to the skin and fascia. in only one case ...20071929014
aberrant expression of intestinal mucin antigens associated with colorectal carcinoma defined by a panel of monoclonal antibodies.small intestine mucin antigen (sima) is an oncofoetal antigen for the colon and is distinct from the normal large intestinal mucin antigen (lima). in the present study, a panel of anti-sima and anti-lima monoclonal antibodies (mab) was used to charaterise altered mucin expression in colorectal adenocarcinomas, by immunohistochemistry and quantitative immunoassays of tissue extracts. these results are compared with cea expression and correlated with various clinicopathological indices. all mucin ...20071931599
[qualitative study of proteinuria in diabetic nephropathy].the qualitative features of the proteinuria in diabetic nephropathy was studied by carrying out tests of clearance quotient of igg and albumin in diabetic patients. diabetic patients with micro and macroalbuminuria showed a major selectivity of proteinuria in relation to normoalbuminuric patients; this suggests a loss of anions at glomerular level.20071932490
[wegener's granulomatosis. apropos of a new case and review of the literature].a case of wegener's granulomatosis (wg) is presented, high-lighting the long-term evolution of affliction of the upper airways without diagnosis, as well as the rapid evolution after detection of the rest of the compounds of the syndrome. we show the difficulties in making a differential diagnosis and the clinical improvement with immunosuppressor treatment.20071932493
hepatocyte hepatitis b surface antigen expression in chronic hepatitis b virus carriers in singapore: correlation with viral replication and liver pathology.the hepatocyte hepatitis b surface antigen (hbsag) expression in 149 liver biopsies from 124 chronic hepatitis b virus (hbv) carriers was correlated with serum hbv dna status and histologic activity. hepatocyte hbsag was stained by the peroxidase-antiperoxidase method and serum hbv dna was determined by dot blot hybridization. sixty-five biopsies (44%) showed minimal changes (mc), 82 biopsies (55%) showed chronic liver disease (cld) and 2 biopsies (1%) showed hepatocellular carcinoma. hepatocyte ...19911932667
measurements of compression of ehrlich ascites tumor cells and their relevance to hematogenous metastasis.ehrlich ascites cancer cells were compressed between glass microscope slides by the addition of weights. the projected areas of the cells were measured, and their surface membrane integrity determined by means of trypan-blue exclusion tests under different compression loads of 0 to 800g. the results are compatible with a two-step mechanism for surface rupture; first the cell membrane is unfolded and then stretched, with modest degrees of stretching associated with membrane rupture. it is calcula ...20071932711
alteration in bone marrow adherent layer growth factor expression: a novel mechanism of chronic myelogenous leukemia progression.philadelphia chromosome1 positive (ph1) chronic myelogenous leukemia (cml) is characterized by metamorphosis of the chronic phase to blastic crisis. however, cellular events associated with this transition are poorly understood. to examine the possible participation of hematopoietic growth factors in this process, we studied growth factor expression in adherent layers of bone marrows derived from cml ph1 patients in various stages of the disease. interleukin-1 beta (il-1 beta) and il-6 mrna were ...19911932751
an analysis of the acog and aap ethics statements on conflicts in maternal-fetal care. 20071932792
nuclear medicine imaging. 20071932819
[facial aging. the evolution of the soft tissues].ageing of the face is one of the most apparent. face varies in shape and aspect. the reasons of these modifications are various: skin ageing, lost of teeth, changes in facial skeleton and modifications of the whole facial soft tissues. soft tissues evolution in mentalis and anterior nasal spin regions was studied on a 206, 21 to 101 years old subjects population. it was shown that in both men and women samples the soft tissues thickness increase in the mentalis region and decrease in that of ant ...20071932872
leprosy in reaction. 20071932917
angioplasty and restenosis. 20071932928
role of diabetes. 20071932942
malingerers, vagrants, and extracontractual arrangements. 20071932961
exogenous surfactants. 20071932965
effects of induced elated and depressed mood on self-focused attention.recent accounts of depression propose a central role for increased self-focus in the onset and maintenance of depression. the present study investigated whether there might also be a converse effect of depressed mood increasing self-focus. a state measure of self-focused attention was administered to normal subjects before and after induction of depressed or happy mood. compared to happy subjects, depressed subjects showed more negative and less positive self-focus. positive and negative externa ...20071933048
a case of ocular tilt reaction and torsional nystagmus due to direct stimulation of the midbrain in man.a case is presented of a patient who underwent insertion of a periaqueductal grey electrode for the relief of chronic pain. shortly after insertion, the patient developed a left-sided ocular tilt reaction (otr). the electrode tip, initially to the right of the midline, was then withdrawn slightly so that it was now on the left side. stimulation at this point gave rise to a worsening of the tilt reaction, in addition to bilateral counter-clockwise torsional nystagmus. computerized tomography and ...19911933234
effect of a nonpeptide angiotensin ii receptor antagonist, dup 753, on angiotensin-related water intake in rats.the effect of peripheral administration of the nonpeptide angiotensin ii-1 (aii) receptor blocker, dup 753, on the dipsogenic responses to peripherally administered angiotensins i, ii, and iii was tested. in all cases, dup 753 significantly inhibited the drinking response, whether administered 15 or 45 minutes prior to administration of the dipsogen. these results suggest that the drinking responses to angiotensins i, ii, and iii are mediated by aii-1 receptors. they also suggest that either aii ...19911933441
lung cancer and smoking. 20071933539
drug use during breast-feeding.the physicochemical and pharmacokinetic factors involved in transfer of drugs into breast milk are reviewed. passage of drugs into milk can best be viewed as a two-compartment system. various ratios of the drug concentration values in the two compartments and ratios of maternal-to-infant intake have been described. knowledge of the limitations of these methods is necessary to properly interpret and apply the literature on drug excretion into breast milk. factors involved in choosing a drug for a ...19911934918
laboratory testing in organ transplantation. laboratory management: regulation of clinical laboratories. 20041934963
the v antigen of yersiniae: an overview. 19911935079
chromosomal marker for the 'high pathogenicity' phenotype in yersinia. 19911935090
preparation of monoclonal antibody to v antigen from yersinia pestis. 19911935094
persistent survival of attenuated yersinia pestis organisms with coexistence of chondroitin sulfate colloidal iron within guinea pig macrophages as an initial step of the induction of potent antiplague immunogenesis. 19911935095
myopic excimer laser keratectomy. a preliminary report. 20071936430
a new strategy to improve a cauliflower mosaic virus vector.co-infection of plants with non-overlapping deletion mutants of cauliflower mosaic virus usually leads to the production of the wild-type virus. to prevent this, a pair of mutants with overlapping deletions was constructed. in infected plants both mutant dnas were stably maintained. such mutants with overlapping deletions will be used as a vector to overcome the size limitation of genes to be cloned.20071937020
the cell cycle-regulated flagellar gene flbf of caulobacter crescentus is homologous to a virulence locus (lcrd) of yersinia pestis.we have characterized flbf, a key locus located at the top of the flagellar gene hierarchy of caulobacter crescentus. this gene is required for transcription from sigma 54 promoters of fla genes expressed late in the cell cycle. we have determined the nucleotide sequence of the gene, mapped the 5' end of the flbf rna, and examined the pattern of expression in the cell cycle. our results show that flbf is expressed earlier in the cell cycle than other fla genes, that it is expressed at a low leve ...19911938923
four-week inhalation exposures of rats to aerosols of three lubricant base oils.sprague-dawley rats were exposed to aerosols of one of three base stocks used to formulate lubricating oils. these stocks were a solvent-refined oil (sro), a hydrotreated and acid-washed white oil (wto) and a severely hydrotreated and hydrocracked oil (hbo). exposures were for 6 h per day, 5 days per week for ca. 4 weeks. there were four groups of rats for each study (10 per sex per group). aerosol concentrations were ca. 0, 50, 210 and 1000 mg m-3 for each material; the mass median aerodynamic ...19911940005
disturbed metabolism of glucose and related hormones in familial amyloidotic polyneuropathy: hypersensitivities of the autonomic nervous system and therapeutic prevention.regulation of glucose metabolism was evaluated by oral glucose tolerance test (ogtt) in patients with familial amyloidotic polyneuropathy (fap). upon oral administration of a loading dose of glucose, plasma levels of glucose, insulin and glucagon changed abnormally in all fap patients tested. although plasma levels of glucose and insulin in the fasted patients were within normal ranges, 33% of fap patients showed hypoglycemia after transient hyperinsulinemia during the examination. furthermore, ...20071940028
image cytometry of progesterone receptor expression during the cell cycle in the mcf-7 cell line.progesterone receptors (pr) appear to be distributed in a heterogeneous way in mammary tumor cells. the study presented here was designed to examine if heterogeneity of pr expression is cell-cycle dependent. immunofluorescence techniques were used to label pr on the mcf-7 human breast cancer cell line and image cytometry was used to analyze the pr expression during g0 (ki-67 antigen-negative cells), g1, s, and g2/m cell-cycle phases. a second pr, brdu, and dna analysis was performed to study pr ...19911940323
maternal hydration increases amniotic fluid index.although adequate amniotic fluid (af) volume is considered an important aspect of fetal well-being, the etiology of decreased af volume is not well understood. a randomized blinded trial was designed to examine our hypothesis that maternal hydration would increase the af index in women with low af indexes. women seen in our testing centers were randomized into control or hydration groups. the control group was instructed to drink their normal amount of fluid; the hydration group was instructed t ...20061945215
maternal hydration increases amniotic fluid index.although adequate amniotic fluid (af) volume is considered an important aspect of fetal well-being, the etiology of decreased af volume is not well understood. a randomized blinded trial was designed to examine our hypothesis that maternal hydration would increase the af index in women with low af indexes. women seen in our testing centers were randomized into control or hydration groups. the control group was instructed to drink their normal amount of fluid; the hydration group was instructed t ...20061945215
[dental health and dental attendance among 25- and 40-year olds].dental and periodontal status and treatment needs were among the parameters assessed and related to the use of oral health services of 25- and 40-year olds in the community of balsfjord, northern norway. the 25-year olds were found to have an average of 27.3 teeth. 13.6 dmft and no deep periodontal pockets (greater than 5.5 mm). the oldest group had an average of 20.2 teeth. twenty per cent wore a full denture in one or both jaws, and deep periodontal pockets were found in 6% of remaining sextan ...20071945814
[clinical research--have the urologists find the road to the future?]. 20071948862
onchocerciasis infection in children born during 14 years of simulium control in west africa.the incidence of onchocerciasis infection in children born since the start of vector control is one of the indicators used in the epidemiological evaluation of the onchocerciasis control programme in west africa (ocp). though initially of littel value, after a decade of control it has become a sensitive indicator of residual transmission. the results of 14 years of control are reported. in 179 villages parasitological surveys were undertaken at intervals of 3-4 years. 15,286 children were examin ...20071949145
[treatment of breastplate deformities: assessment using ct scanning and functional tests].a study to evaluate both the pre- en postoperative functional and morphologic status of major anterior chest wall deformities. four of the eight patients suffered from a progressive reduction in physical capabilities. preoperative pulmonary function tests demonstrated restriction in pulmonary function. in the postoperative period there was progressive return to normal physical strength without objective improvement in pulmonary function. pre- and postoperative thoracometric study by ct scan allo ...20071950309
tympanic membrane retraction pockets. etiology, pathogeny, treatment.the author describes the morphological behaviour of the tympanic membrane, undergoing long term negative pressure in the middle ear cavities. he explains the viscoelastic properties of the tympanic membrane lamina propria, in cases of retraction pockets. he analyses the preferential weakness of some well localized parts of the tympanic membrane and defends an accurate treatment to avoid this pathology.20071950545
haloperidol and lithium carbonate treatment did not influence serum immunoglobulin levels in schizophrenic and affective patients.serum immunoglobulin levels were studied in 153 psychiatric patients (87 schizophrenic, 48 bipolar and 18 unipolar patients), and 35 healthy controls. psychotropic treatments (haloperidol in the schizophrenic patients and lithium in the bipolar affective patients) did not alter serum immunoglobulin levels. decreased mean igm serum level was detected in the major affective patients (unipolar and bipolar) compared with normal controls. nonspecific environmental, infectious, autoimmune and emotiona ...20071950622
increased vitamin e intake restores fish-oil-induced suppressed blastogenesis of mitogen-stimulated t lymphocytes.we sought to determine whether fish-oil supplementation would suppress blastogenesis in vitro of concanavalin a (cona)-stimulated peripheral blood mononuclear cells (pbmcs) and, if so, whether it could be reversed with increased intake of vitamin e. healthy males ate a controlled basal diet providing a total of 40% of energy from fat when fed in conjunction with 15 g/d of either placebo oil (po) or fish-oil concentrate (foc) fortified with 15 mg alpha-tocopherol/d for three periods. the subjects ...20071951163
120-hour 5-fluorouracil (5-fu) continuous infusion (ci) plus bcnu in advanced colorectal cancer.seventy-five previously untreated patients with measurable advanced colorectal cancer were treated with 5 fluorouracil 1,000 mg/m2 as a 24-hour intravenous (i.v.) continuous infusion during days 1-5 and 28-32 every cycle, plus 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu), 200 mg/m2 i.v. bolus on day 1, all given every 8 weeks up to 6 cycles. median karnofsky performance status (kps) was 100. sites of disease at entry were mainly the abdomen (45%) and liver (33%). all patients were evaluable for r ...20071951175
intrusion of posterior teeth with magnets: an experiment in nongrowing baboons. 20071951192
prevalence of birth defects among low-birth-weight infants. a population study.major birth defects are diagnosed in about 3% to 4% of infants during their first year of life. because many infants with birth defects have intrauterine growth retardation, are born prematurely, or both, the rate of birth defects undoubtedly varies according to the infant's birth weight. nevertheless, the magnitude of such variation has not, to our knowledge, been adequately studied in well-defined populations. we analyzed data from the population-based metropolitan atlanta (ga) congenital defe ...20071951228
pyogenic meningitis and cerebral abscesses after endoscopic injection sclerotherapy.infectious complications of endoscopic injection sclerotherapy (eis) are rare. we report here a case in which pyogenic meningitis and multiple cerebral abscesses developed after a session of eis. the patient was successfully treated with a combination of parenteral antibiotics and repeated bedside pus aspirations. prophylactic antibiotics may be considered in such situations for subsequent sessions of eis.20071951249
using dead controls to adjust for confounders in case-control studies.the use of dead controls in a case-control study, the primary purpose of which is to control for confounding, leads to consistent relative risk estimates within stratum of the confounder, even if the causes of death of controls are associated with that confounder. dead controls may be more comparable to dead cases in terms of data quality, and therefore, under these circumstances, the use of dead controls may be advantageous.20071951273
age- and sex-specific cycles in united states suicides, 1973 to 1985.total us suicides peak on the first day of each week, in the first week of each month, and in the late spring of each year. although these cycles are assumed to characterize all us suicides, analyses by age and sex show that the cycles occur only in a few subpopulations. day-of-the-week effects are found almost exclusively in middle-aged suicides; day-of-the-month effects are found almost exclusively in elderly male suicides; and month-of-the-year effects asre found almost exclusively in teenage ...20071951813
[cytological examination of urethral and endocervical smears in the diagnosis of infections].cytologic studies of smears from 130 women suffering from various diseases, including 61 pregnant patients with gestoses, have shown structural changes of the cells in the smears from the endocervix and urethra, that permitted the diagnosis of mycoplasma infection in 43.8% of patients, chlamydia infection, 52.3%, and herpes simplex in 72.3% of patients; in 63.9% of patients these infections were combined. cytologic studies may be useful in the tentative diagnosis of urogenital infections, includ ...19911951977
angiosarcoma in postsurgical lymphedema. an unusual occurrence in a man.a 63-year-old man underwent partial left axillary node dissection for metastatic melanoma of unknown primary. lymphedema of his left upper extremity developed after surgery. eight years later, extensive cutaneous angiosarcoma developed in the edematous limb. the occurrence of cutaneous angiosarcoma in postsurgical lymphedema is extremely rare in men; to our knowledge, our case is the fifth such case thus far reported.19911951986
severe earache following nitrous oxide anaesthesia. 20071952025
blood pressure cuff changeover in paediatric anaesthesia. 20071952028
[the ozone layer and its modification by n2o and inhalation anesthetics].as a result of human activities the ozone layer in the stratosphere, which is necessary for life on earth, has changed. the main causes of ozone destruction are chlorofluorcarbons (cfcs) 11 and 12. recently, caring anesthetists have wondered if and to what degree n2o and popular potent inhalation anesthetics may also contribute to ozone loss. having consulted the literature, we attempt to answer that question. the ozone-destroying n2o is chiefly produced by burning fossil elements and nitrogenou ...19911952035
ana realizes victories for nurses, patients. 20051952356
[various properties of rifr mutants of the plague agent].the properties of the rifr mutants of four vaccinal and two natural strains of the plague bacillus were studied. the frequency of the mutants not growing on the complete nutrient medium after increasing the cultivation temperature to 37 degrees c averaged to 3.10(-1). the frequency of the loss of every of the three known autonomous plasmids or combinations of the 6-md and 65-md plasmids was n.10(-1). in the mutants of some strains with the preserved 47-md plasmid sensitivity to the ca2+ deficien ...19911953182
exaggerated natri-calci-uresis and increased circulating levels of parathyroid hormone and 1,25-dihydroxyvitamin d in patients with senile hypertension.renal handling of na and ca in response to physiological saline infusion (20 ml/kg i.v. for 2 h) was compared between 27 hypertensive (mean +/- sd age 79.8 +/- 9.2 years) and 44 normotensive (79.1 +/- 4.1 years) senile females. compared to the normotensive group, the hypertensive group showed statistically significant decreases in the basal values of serum ca and pra, and significant increases in basal circulating levels of parathyroid hormone and 1,25(oh)2d and in urinary excretions of na, ca a ...20071959361
integration of the plasmid encoding the synthesis of capsular antigen and murine toxin into yersinia pestis chromosome.yersinia pestis, the causative agent of plague, usually carries three plasmids. the largest of them, a 60 megadalton (mda) replicon designated pfra determines the synthesis of capsular antigen (fraction i) and murine toxin. both products are involved in the expression of virulence. previously, several cases of integration into the bacterial chromosome of the calcium dependence plasmid common to pathogenic yersinia species have been described. in this study, using the southern hybridization metho ...19911961108
[the use of lisinopril for congestive heart failure]. 20071965521
[the peptidase activity of a cellular extract of the causative agent of plague].peptidase activity of yersinia pestis cell extract was studied by the hydrolysis of synthetic and some natural substrates, as well as the hydrolysis of fluorogenic aminopeptidase substrates. all peptides and fluorogenic substrates under test were split by y. pestis cell extract, the splitting of alanylaminopeptidase substrate being linked with at least two enzymes of this cell extract.19901973325
[the phenomenon of pilus formation in the interaction of yersinia pestis with macrophages in experimental animals].according to the data of the enzyme immunoassay, adhesion pili were expressed by y. pestis cells eb76 after their cultivation in media with ph similar to that of phagolysosomes. the expression of adhesion pili was found to occur 18 hours after the contact of apiliate cells eb76 with a monolayer of native, but not inactivated (at 56 degrees c for 30 minutes) macrophages of the peritoneal exudate of white mice and guinea pigs. purified adhesion pili possessed cytotoxic action and inhibited the dig ...19901973326
hypothalamo-pituitary axes and feedback control in amphibians and reptiles. 20071974782
failure of chronic glutathione elevation to reduce cytotoxicity produced by exposure to cis-diamminedichloroplatinum(ii), ionizing radiation, or hyperthermia.chinese hamster ovary (cho) cells cultured in vitro were continuously exposed to increasing concentrations of diethylmaleate (dem). chronic exposure of these cells (designated cho/dem) to 80 microm diethylmaleate resulted in an increase in cystine transport, a decrease in glutathione inhibition of the enzyme gamma-glutamylcysteine synthetase, elevation of intracellular glutathione levels to 4.3 times control, and elevation of glutathione-s-transferase activity by 6.6 times. yet, cho/dem and cont ...20071974822
codon 72 polymorphism of the tp53 gene. 19901975675
close relationships between neopterin and beta-2-microglobulin levels in intravenous drug abusers.serum from 36 intravenous drug abusers without acquired immunodeficiency syndrome (aids) or aids-related complex were tested for concentrations of neopterin and beta 2-microglobulin. the seroprevalence of human immunodeficiency virus (hiv) antibody in this group was 50%. previous studies of this group showed that the hiv antibody positive patients had significant increases in hla-dr expression on peripheral blood lymphocytes and increases in serum soluble cd8 antigen. both neopterin and beta 2-m ...19901976599
[the effect of the adhesion pili of yersinia pestis on the physiological activity of the leukocytes and macrophages in experimental animals].the data on the influence of the preparation of y. pestis adhesion pili on peritoneal macrophages in white mice and guinea pigs are presented. y. pestis adhesion pili have been found to induce the dose-dependent increase of cell chemiluminescence. they have also been found to induce a number of biochemical changes in target cells: the secretion of myeloperoxidase, an increase in the activity of camp-dependent protein kinases.19901978453
molecular biology of the cuticle collagen gene families of caenorhabditis elegans and haemonchus contortus. 19901978527
a cloned chromosomal dna fragment which differentiates yersinia pestis from yersinia pseudotuberculosis and yersinia enterocolitica.chromosomal dna from reference yersinia strains was digested individually with 9 restriction endonucleases. dna fragments were separated and analyzed by electrophoresis through agarose gels. the clearest fragment patterns were obtained when ecori was employed. the y. pestis fragment pattern obtained after the use of this enzyme showed the presence of a unique dna fragment with molecular mass 1400 bp. this dna fragment was cloned, purified, labeled with 32p and then used to probe ecori digests of ...19901980253
[the effect of the "37 degrees c--low ph" signal on cells of yersinia pestis].it is established that the synthesis of adhesion piles registered by the results of immunoenzyme analysis and immunoblotting starts 90 min after the action on apilated cells of plaque microbe eb-76 of the signal "37 degrees c-low ph" (cultivation at 37 degrees c and acidic ph). under these conditions a part of cell piline is in a form connected with cells and only inconsiderable part (to 20%) is represented in a form of "classical" piles possessing hemagglutinating activity. it is shown that in ...19901982158
measurement of attitudes and behaviors in public health surveys.we divided 900 general practitioners into two groups: one group received a questionnaire measuring both attitudes and behaviors toward preventive aspects of medical care, while the other received two separate questionnaires--one measuring behaviors, and one measuring attitudes. response rates of the two groups were similar. respondents in the first group retrieved their answer to the attitudinal items when responding to behavioral items, increasing the correlations between attitudes and behavior ...20071983905
traumatic subarachnoid-pleural fistula in a child. a case report.a seven-year-old girl sustained a gunshot wound to the chest and spine. evaluation of a persistent pleural effusion demonstrated a subarachnoid-pleural fistula. surgical closure of the dural defect resulted in resolution of the fistula. traumatic subarachnoid-pleural fistulae are rare. the diagnosis is reached by an awareness of fistula formation from penetrating or blunt trauma to the chest.20071997234
[the effect of the application technic on the formal success of large-field radiotherapies].198 patients suffering from hodgkin's disease or non-hodgkin's lymphomas were irradiated with large-field techniques from 1979 to 1988. 129 of these were treated with common block techniques whereas the field-integrated dose modification (fidm) was applied to 69 patients. retrospective analysis shows that fidm decreases acute toxicity. this was also evident in those patients who were irradiated by accelerated hyperfractionation. although single doses were higher in patients treated with fidm tre ...20072000545
class c firework injuries in a pediatric population.class c fireworks are those which can be readily purchased by the public. between july 1971 and august 1988, 23 patients were admitted to our institution with firework injuries. fourteen patients (60.9%) sustained injuries related to class c fireworks. all patients were males with a mean age of 9.0 +/- 3.6 years, with a total body surface area (tbsa) burn of 18 +/- 20% with 10 +/- 15% being full thickness. thirteen of the 14 patients required hospitalization. five patients were admitted acutely ...20072002527
woodchuck hepatitis virus is a more efficient oncogenic agent than ground squirrel hepatitis virus in a common host.chronic infection with hepatitis b viruses (hepadnaviruses) is a major cause of hepatocellular carcinoma (hcc), but the incubation time varies from 1 to 2 years to several decades in different host species infected with indigenous viruses. to discern the influence of viral and host factors on the kinetics of induction of hcc, we exploited the recent observation that ground squirrel hepatitis virus (gshv) is infectious in woodchucks (c. seeger, p. l. marion, d. ganem, and h. e. varmus, j. virol. ...19912002538
evaluation of preoperative investigations in patients admitted for ovarian primary cytoreductive surgery.consistent with universally established practice, it has been customary in our unit to subject patients with clinically suspected or biopsy proven ovarian cancer to a large number of preoperative investigations. this is in order to determine metastases, surgical strategy, and exclusion of pelvic kidney. this study presents a comparison of the preoperative ultrasonography, computerized tomography, intravenous pyelography, chest x-ray, liver and bone scintigraphy, and barium enema results performe ...19682013447
plasma amine oxidase activities in norrie disease patients with an x-chromosomal deletion affecting monoamine oxidase.two individuals with an x-chromosomal deletion were recently found to lack the genes encoding monoamine oxidase type a (mao-a) and mao-b. this abnormality was associated with almost total (90%) reductions in the oxidatively deaminated urinary metabolites of the mao-a substrate, norepinephrine, and with marked (100-fold) increases in an mao-b substrate, phenylethylamine, confirming systemic functional consequences of the genetic enzyme deficiency. however, urinary concentrations of the deaminated ...20072018626
stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology.the blood-brain barrier transport characteristics of racemic baclofen and the separate r- and s-enantiomers have been determined in vivo in rats by using the unit impulse response methodology. transport rate was determined as blood-brain barrier clearance, the volume of plasma per unit time cleared of baclofen by transport across the blood-brain barrier. plasma elimination kinetics and csf elimination kinetics did not differ among racemic baclofen and the r- and s-enantiomers. transport of each ...19912023878
stereoselective transport of baclofen across the blood-brain barrier in rats as determined by the unit impulse response methodology.the blood-brain barrier transport characteristics of racemic baclofen and the separate r- and s-enantiomers have been determined in vivo in rats by using the unit impulse response methodology. transport rate was determined as blood-brain barrier clearance, the volume of plasma per unit time cleared of baclofen by transport across the blood-brain barrier. plasma elimination kinetics and csf elimination kinetics did not differ among racemic baclofen and the r- and s-enantiomers. transport of each ...19912023878
extradural opioids. 20072031827
anticlastogenic activity of beta-carotene against cyclophosphamide in mice in vivo.beta-carotene (bc), a natural food colourant and an antioxidant, acts as an antimutagen/anticarcinogen in several test systems. the anticlastogenic activity of bc against cyclophosphamide (cp) was studied in bone marrow cells of mice in vivo. seven days' oral priming with bc (2.7 and 27 mg/kg b.w.) followed by an acute treatment with cyclophosphamide (25 mg/kg b.w.; i.p.) inhibited clastogenicity. the values of chromosomal aberrations and micronucleated polychromatic erythrocytes were consistent ...20072034238
immune responses of two mastomys sibling species to yersinia pestis.this study assessed the in vitro cell-mediated immune responses of mastomys natalensis, with a diploid chromosome number of 2n = 32, and mastomys coucha, with a diploid chromosome number of 2n = 36, to yersinia pestis. splenic mononuclear (mn) cells of uninfected m. natalensis proliferated in response to crude fraction 1 of y. pestis and two subfractions derived from fraction 1 in vitro. proliferation was dose dependent and followed the time kinetics of other well-known mitogens. further charact ...19912037358
erythropoietin and the myelodysplastic syndrome. 20072040188
the safety of epoetin-alpha: results of clinical trials in the united states. 20072040198
intraperitoneal chemotherapy. 20072042064
angiotensin converting enzyme inhibition. systemic and regional hemodynamics in rats and humans.the systemic and regional hemodynamic effects of angiotensin i converting enzyme inhibitors (aceis) have been investigated using different experimental methods (pulsed doppler, radioactive microspheres), either in rats (normotensive nt or genetically hypertensive shrs) or in humans (healthy volunteers or patients with congestive heart failure chf). all aceis decreased systemic vascular resistance but the profile of their peripheral vasodilating properties was heterogeneous. acei-induced vasodila ...19912043315
sir frederick hobday memorial lecture. all wind and water: some progress in the study of equine gut motility. 19912044514
glucagon and clonidine testing in the diagnosis of pheochromocytoma.we assessed the sensitivity and specificity of glucagon stimulation and clonidine suppression tests in the diagnosis of pheochromocytoma in 113 hypertensive patients, 39 with and 74 without the tumor. in the glucagon stimulation test, blood was sampled 2 minutes after intravenous injection of 0.28 mumol (1 mg) glucagon, and in the clonidine suppression test, blood was sampled 3 hours after administration of oral clonidine, 1.30 mumol (0.3 mg)/70 kg body wt. baseline levels of catechols in antecu ...20072045133
juxtamedullary afferent arteriolar responses to p1 and p2 purinergic stimulation.we assessed the responsiveness of rat juxtamedullary afferent arterioles to purinergic stimulation using the in vitro blood-perfused juxtamedullary nephron technique combined with videomicroscopy to allow direct measurement of arteriolar inside diameter. to minimize the contribution of endogenously formed angiotensin ii, all rats were pretreated with enalaprilat (2 mg i.v.) for 30 minutes before the right kidney was isolated and prepared for study. renal perfusion pressure was set at 110 mm hg a ...19912045147
central effect of endothelin on neurohormonal responses in conscious rabbits.it has been shown that endothelin-1 (et-1) binding sites exist in the central nervous system and that the injection of intracerebroventricular et-1 induces a pressor response. therefore, we determined the neurohormonal and cardiovascular responses to intracerebroventricular et-1 (25 pmol/kg) in conscious rabbits with chronically instrumented electrodes on the renal sympathetic nerve. intracerebroventricular et-1 provoked a prompt increase in arterial pressure and in renal sympathetic nerve activ ...19912045164
augmentation of endothelium-independent flow constriction in pial arteries at high intravascular pressures.the effects of an increase in intraluminal pressure and flow on the diameter and active smooth muscle tone of pial arteries was studied in perfused segments. resistance arteries (approximately 250-300 microns i.d.) were perfused under controlled pressure and flow conditions, and changes in arterial diameter registered with an automated video device. in any particular segment, diameter measurements were normalized to that observed at 5 mm hg. changes in active wall force were determined by relati ...19912045168
[morbidity in primary health care: patients versus visits].the introduction of the family and community medicine specialist in spain implied the beginning of an epidemiological approach in the activities of primary care, and the publication of the first studies on cared morbidity. variations in tolerance threshold to illness by patients, differences in perception of health problems by physicians, the lack of a consensus on the definition of events that should be registered, together with the lack of a census of the eligible population are important prob ...20072045226
the us: transmission of hiv in a dental office. 19912045229
fumonisin mycotoxins and equine leukoencephalomalacia. 19912045319
spontaneous fracture of a vena-tech inferior vena caval filter. 20072048515
nomenclature of veins in the lower extremity. 20072048529
plague and tularemia.human plague is a local or systemic flea-transmitted infection caused by yersinia pestis. it is maintained in well established enzootic foci among wild rodents. this article discusses the clinical findings in plague, diagnosis, treatment, and prevention of plague, and management of contacts of human plague cases and of exposures to epizootic plague. tularemia shares many features with plague but is widespread in animal and arthropod vector populations and essentially throughout the united states ...19912051013
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