Publications

TitleAbstractYear
Filter
PMID(sorted ascending)
Filter
recovery of lyme disease spirochetes from patients.since the summer of 1982, we have cultured patient specimens for lyme disease spirochetes. of 118 patients cultured, four specimens yielded spirochetes: two from blood, one from a skin biopsy specimen of erythema chronicum migrans (ecm), and one from cerebrospinal fluid. all four isolates appeared identical when examined with a monoclonal antibody. however, attempts to recover the spirochete from synovium or synovial fluid were unsuccessful. in addition, the organism could not be visualized in s ...20166393606
the antibody response in lyme disease.we determined the antibody response against the ixodes dammini spirochete in lyme disease patients by indirect immunofluorescence and an enzyme-linked immunosorbent assay (elisa). the specific igm response became maximal three to six weeks after disease onset, and then declined, although titers sometimes remained elevated during later disease. specific igm levels correlated directly with total serum igm. the specific igg response, often delayed initially, was nearly always present during neuriti ...19846393607
immunodiagnostic tests for lyme disease.standardized serologic tests for lyme disease are needed, as isolation or in situ demonstration of the spirochete has proved difficult. at the centers for disease control (cdc), an indirect immunofluorescence assay (ifa) was modified from a previously described ifa, and an enzyme-linked immunosorbent assay (elisa) was developed with soluble spirochetal antigens. both tests were evaluated with sera from lyme disease patients, normal controls, and patients with other diseases. they were highly spe ...20136393608
immunochemical analysis of lyme disease spirochetes.sera from patients with lyme disease (ld) originating in the united states and europe were examined by western blot analysis for antibodies to ld spirochete components. whereas some components reacted with antibodies from the majority of patients, other components, notably an abundant cellular protein with an apparent molecular weight of 34,000 were less commonly bound. this latter proteinaceous component was in a region of the polyacrylamide gel electrophoresis profile which demonstrated variab ...20136393610
phagocytic cell responses to in vivo and in vitro exposure to the lyme disease spirochete.an experimental skin lesion induced in rabbits by the bite of infected adult ixodes dammini showed dense dermal interstitial inflammatory cell infiltrates composed of mononuclear cells (histiocytes and lymphocytes) and granulocytes. the prevalence of phagocytic cells in this experimental lesion motivated a study on the interactions of macrophages and neutrophils with lyme disease spirochetes. interactions as measured by uptake of radiolabeled spirochetes and by indirect immunofluorescence were e ...19846393611
the new zealand white rabbit: an experimental host for infecting ticks with lyme disease spirochetes.efficiency of the new zealand white rabbit as a host for infecting larval ixodes dammini, i. pacificus, and i. ricinus with lyme disease spirochetes was evaluated. rabbits inoculated with infected midgut suspensions of i. dammini from shelter island, new york, or fed upon by infected ticks from the same area, responded with spirochetemias of sufficient concentrations to infect as many as 30 percent of the ticks. when infected ticks were used as indicators, it appeared that spirochetemias persist ...19846393612
infection in rabbits with the lyme disease spirochete.of 33 rabbits inoculated with lyme disease spirochetes, two developed erythema chronicum migrans at the site of inoculation. spirochetes were seen in skin biopsies of one of the lesions with immunoperoxidase and warthin-starry stains. spirochetes were also recovered from the blood of two additional rabbits two weeks post-inoculation. these findings are characteristic of early lyme disease in humans.19846393613
lyme disease in new jersey, 1978-1982.from 1978 to 1982, 117 cases of lyme disease were reported in new jersey. the number of cases increased each year from four in 1978 and 1979 to 56 in 1982. forty-eight percent of cases occurred in a four-township area in central monmouth county. the proportion of cases with arthritis decreased in 1982 because of early antibiotic treatment and better reporting of milder cases. the proportion of cases with positive serology increased with severity of the clinical syndrome. about 25 percent of pati ...20136393614
lyme disease in minnesota: epidemiologic and serologic findings.during the four years, 1980 to 1983, 83 minnesota residents have been diagnosed with lyme disease. sixty-five of the patients were male. the median age of patients was 39 years with a range from one to 77 years. seventy-five (90 percent) had onset in 1982 and 1983. of these latter cases, 56 (75 percent) recalled a tick bite three to 27 days prior to the development of erythema chronicum migrans. patients experienced possible exposure to ixodes dammini in at least 24 (28 percent) of the 87 minnes ...19846393615
lyme disease: a review. 19846394029
[lyme disease--another tick-borne disease in austria].infection with tick-borne spirochetes (e.g. borrelia burgdorferi) may lead to the development of erythema chronicum migrans, acrodermatitis atrophicans, meningopolyneuritis bannwarth, and a special type of reactive arthritis named lyme disease after the american endemic area. since these diseases occur also in austria, their clinical features are described in this review; a clear distinction must be made between the neurological manifestation of lyme disease and those of tick-bite mediated early ...19846396970
treatment of the early manifestations of lyme disease.during 1980 and 1981, we compared antibiotic regimens in 108 adult patients with early lyme disease. erythema chronicum migrans and its associated symptoms resolved faster in penicillin- or tetracycline-treated patients than in those given erythromycin (mean duration, 5.4 and 5.7 versus 9.2 days, f = 3.38, p less than 0.05). none of 39 patients given tetracycline developed major late complications (meningoencephalitis, myocarditis, or recurrent attacks of arthritis) compared with 3 of 40 penicil ...19836407378
lyme disease is a spirochetosis. a review of the disease and evidence for its cause.fourteen patients with lyme disease showed typical clinical features of erythema chronicum migrans. eighteen biopsy specimens in all were obtained from the cutaneous lesions of these patients. the predominant histologic finding was a superficial and deep perivascular and interstitial infiltrate composed mostly of lymphocytes, or lymphocytes and either plasma cells and eosinophils or both. the plasma cells were found most frequently in biopsy specimens taken from the peripheries of the lesions, w ...19836410931
[lyme disease. a new or newly recognized clinical entity]. 19836415420
update: lyme disease--united states. 19846425627
lyme disease: prevention of the arthritis syndrome through early recognition and antibiotic therapy. 19846427143
erythema chronicum migrans of lyme disease.erythema chronicum migrans (ecm) is the distinctive cutaneous lesion of the multisystem tick-borne spirochetosis, lyme disease. its clinical and histologic pictures are variable. of the 51 patients with ecm of lyme disease, 38 patients (75%) had single lesions, 13 patients (25%) had multiple lesions, and 32 patients (62%) had extracutaneous signs and symptoms. only 15 patients (29%) had symptoms referable to ecm. extracutaneous signs and symptoms were absent in 12 (80%) of the 15 patients. these ...19846465906
[lyme disease in sweden. a patient with arthralgia associated with chronic erythema migrans]. 19846471976
lyme disease as an etiology of "unexplained" recurrent monoarthritis. 19846472235
a focus of lyme disease in monmouth county, new jersey.an endemic focus of lyme disease is present in colt's neck, howell, freehold, and wall townships in monmouth county, new jersey. cases of lyme disease have occurred in this area from 1978 to 1982. fifty-seven of the 117 persons (49%) who acquired their infection in new jersey from 1978 to 1982 live or work in these four townships, whose population of 82,491 is only 1.1% of the population of the entire state. thirty persons who contracted lyme disease were exposed to ticks at the naval weapons st ...19846475916
thirteen british cases of erythema chronicum migrans, a spirochaetal disease.thirteen british cases of erythema chronicum migrans are reported. an antibody to the lyme disease spirochaete was found in three of five recent cases, but lyme disease was not seen. the distribution and life cycle of the tick ixodes ricinus is described and related to the occurrence of erythema chronicum migrans in great britain.19846477830
experimental lyme disease in rabbits: spirochetes found in erythema migrans and blood.in attempts to produce experimental lyme disease, 33 rabbits were inoculated with lyme spirochetes by tick feeding or from tick organ homogenates or cultures. two rabbits developed erythema chronicum migrans at the site of inoculation, in one instance 2 days after injection of a tick organ homogenate and in the other instance, 17 days after feeding of infected ixodes dammini ticks. spirochetes were seen in skin biopsy specimens of the second lesion with warthin-starry and immunoperoxidase stains ...19846480108
update: lyme disease--united states. 19846480956
the spirochetal etiology of lymphocytic meningoradiculitis of bannwarth (bannwarth's syndrome).in all the sera of four patients with meningoradiculitis of bannwarth admitted to the neurological department of the university clinic grosshadern in munich in 1983, we found antibodies against ixodes dammini spirochetes. in three patients antibodies were also present in the csf. in one patient, we isolated spirochetes from the csf and demonstrated specific igg antibodies in serum and csf. this spirochete was morphologically indistinguishable from the i. dammini spirochete and a spirochete isola ...19846481420
update on article on lyme disease. 19846490408
genetic relationship of lyme disease spirochetes to borrelia, treponema, and leptospira spp.genetic studies were performed on the following spirochetes: three lyme disease spirochetes isolated from ixodes ticks and from human spinal fluid; three species of north american borreliae; four species of treponema; and two species of leptospira. the mol% g+c values for lyme disease spirochetes were 27.3 to 30.5%, similar to values of 28.0 to 30.5% for borrelia species but different from the values of leptospira or treponema species which ranged from 35.3 to 53%. lyme disease spirochetes repre ...19846490811
dna characterization of the spirochete that causes lyme disease.lyme disease, a tick-borne disease long recognized in europe but only recently recognized in the united states, was shown in 1982-1983 to be caused by a spirochete, the lyme disease spirochete. whether one or more species of the spirochete exists is unknown, as is its taxonomic status. to answer these questions, we determined (i) the dna base (guanidine-plus-cytosine) content for five strains; (ii) the dna relatedness of 10 strains from europe or the united states (isolated from ticks, humans, a ...19846490812
failure to detect endotoxin in sera from patients with lyme disease. 19846491371
experimental transmission of the lyme disease spirochete to rabbits. 19846491385
[cardiac manifestations of lyme disease. apropos of 2 cases].lyme disease, a well-known entity in the united states, has featured only rarely in the french literature. we report two cases from the cardiology department with acute symptomatic atrio-ventricular block. the illness begins with migratory chronic erythema, which is the best marker of the condition. this is followed by neurological, joint and cardiac manifestations. cardiac involvement consists essentially in a-v block of varying severity, which rapidly regresses. until the recent discovery of t ...19846497303
human phagocyte interactions with the lyme disease spirochete.the interaction between human polymorphonuclear leukocytes and monocytes and the lyme disease spirochete was investigated by incubating phagocytes with microorganisms adherent to plastic or glass surfaces. both cell populations readily phagocytized and killed spirochetes, and antibodies facilitated but were not essential for phagocytosis.19846500703
[chronic migratory erythema: lyme disease?]. 20126510959
a case of lyme disease with cardiac involvement in the netherlands. 20046511091
the clinical spectrum and treatment of lyme disease.lyme disease was recognized as a separate entity because of close geographic clustering of affected children in lyme, connecticut, with what was thought to be juvenile rheumatoid arthritis. it then became apparent that lyme disease is a complex, multisystem disorder. the illness usually begins in summer with erythema chronicum migrans and associated symptoms (stage 1). weeks to months later, some patients develop neurologic or cardiac abnormalities (stage 2), and weeks to years later, many patie ...20166516448
lyme disease: a unique human model for an infectious etiology of rheumatic disease.lyme disease is a complex immune-mediated multi-system disorder that is infectious in origin and inflammatory or "rheumatic" in expression. through its epidemiologic characteristics, large numbers of a seasonally synchronized patient population are readily available for prospective study. lyme disease has a known clinical onset ("zero time"), marked by the characteristic expanding skin lesion, erythema chronicum migrans, and a clearly defined pre-articular phase. at least some manifestations of ...19846516449
neurological findings of lyme disease.neurologic involvement of lyme disease typically consists of meningitis, cranial neuropathy, and radiculoneuritis, alone or in combination, lasting for months. from 1976 to 1983, we studied 38 patients with lyme meningitis. headache and mild neck stiffness, which fluctuated in intensity, and lymphocytic pleocytosis were the common findings. half of the patients also had facial palsies, which were unilateral in 12 and bilateral in seven. in addition, 12 patients had motor and/or sensory radiculon ...20166516450
chronic meningitis and lyme disease in sweden.we studied 35 patients with chronic meningitis. the neurological abnormalities included aseptic meningitis, cranial neuropathy (mostly facial palsy), motor and sensory peripheral radiculoneuropathy, and myelitis. neurological symptoms were sometimes preceded by erythema chronicum migrans or an insect bite and were often accompanied by fever, malaise, profound fatigue, and weight loss. the cerebrospinal fluid (csf) abnormalities consisted of a predominantly mononuclear pleocytosis, an elevated cs ...19846516451
bannwarth's syndrome (lymphocytic meningoradiculitis) in sweden.lymphocytic meningoradiculitis of bannwarth is often associated with a tick bite and erythema chronicum migrans, and therefore may be a european counterpart of lyme disease in north america. of nine patients with lymphocytic meningoradiculitis studied at the neurologic clinic in lund, sweden, six were found to have elevated antibody titers to the lyme spirochete. these studies support the conclusion that the two diseases are related and may be overlapping sectors of a larger clinical spectrum ca ...20136516452
vectorial capacity of north american ixodes ticks.ixodes dammini, the vector of lyme disease and babesiosis, is distributed in various locations in the northeastern quadrant of the united states and nearby canada. the life cycle of this tick, which includes larval, nymphal, and adult stages, spans at least two years. the tick over-winters between larval and nymphal feeding. horizontal transmission of pathogens is facilitated by a feeding pattern in which both the larval and nymphal stages feed on the white-footed mouse, peromyscus leucopus, and ...19846516453
discovery of the lyme disease spirochete and its relation to tick vectors.the various hypotheses concerning the etiologic agent of erythema chronicum migrans of europe and of lyme disease in the united states are reviewed, and an account of events that led to the discovery of the causative spirochetal agent in ixodes dammini is presented. spirochetes morphologically and antigenically similar, if not identical to, the organism detected in i. dammini were also found for the first time in ixodes pacificus and ixodes ricinus, the vectors hitherto incriminated, respectivel ...19846516454
dna characterization of lyme disease spirochetes.lyme disease spirochetes (lds) have phenotypic characteristics of both treponemes and borreliae. to ascertain whether one or more species of lds exist, as well as their taxonomic status, we determined the dna base (g + c) content for three strains of lds, the dna relatedness of ten strains isolated in the united states or europe, and the dna relatedness of lds to other spirochetes. the g + c content of the three lds strains was 28.1-29.0 mol%, most similar to those of borellia hermsii (30.6 mol ...19846516455
susceptibility of the lyme disease spirochete to seven antimicrobial agents.the antimicrobial susceptibility of five lyme disease spirochete strains (two human and three tick isolates) was determined. a macrodilution broth technique was used to determine on three separate test occasions the minimal inhibitory concentrations (mics) of seven antibiotics. the lyme disease spirochete was most susceptible to erythromycin with a mic of less than or equal to 0.06 micrograms/ml. the spirochete was also found to be susceptible to minocycline, ampicillin, doxycycline, and tetracy ...19846516457
the global distribution of lyme disease.following the original description of erythema chronicum migrans (ecm) in sweden in 1909, ecm became widely recognized in europe. the first reported case of ecm acquired in the united states occurred in 1969, and in 1975 the full symptom complex now known as lyme disease was recognized. in 1981, cases of lyme disease were recognized in yet a third continent, australia and, to date, cases acquired in at least 19 countries have been reported. beginning with the original case reported in sweden, cl ...19846516458
geographic distribution of humans, raccoons, and white-footed mice with antibodies to lyme disease spirochetes in connecticut.an indirect immunofluorescence test was used during 1982-1983 to identify antibodies to lyme disease spirochetes in humans, white-footed mice, and raccoons. serologic tests detected igm or total ig antibodies in serum samples from 67 persons. onset of illness, as marked by erythema chronicum migrans (ecm), occurred mainly during july and august. the majority of the persons with lyme disease lived in south central and southeastern connecticut. analyses also verified prior spirochetal infections i ...19846516459
avian and mammalian hosts for spirochete-infected ticks and insects in a lyme disease focus in connecticut.spirochetes and their vectors and reservoirs were studied in a lyme disease focus in east haddam, connecticut, from mid-may through september 1983. ixodes dammini subadults were comparable in number on white-footed mice (peromyscus leucopus) (means = 2.9 +/- 3.6 sd) to those on 27 different species of birds (means = 2.3 +/- 4.2 sd) representing 11 families within the order passeriformes. less commonly found ticks on birds (means less than or equal to 0.1) were immature ixodes dentatus and haemap ...19846516460
prevalence of the lyme disease spirochete in populations of white-tailed deer and white-footed mice.the prevalence of the ixodes dammini spirochete (ids) in white-tailed deer (odocoileus virginianus) and white-footed mice (peromyscus leucopus) was studied on the eastern end of long island, new york. both species commonly occur in a variety of habitats, are preferred hosts of ixodes dammini, and can harbor the spirochetes in the blood. each animal was examined for spirochetemia, tick infestation, and ids infection rates in the ticks that were removed from it. the results obtained suggest that i ...19846516461
[etiology of erythema migrans disease and lyme disease. review and results of personal study].erythema chronicum migrans (ecm), lymphadenosis cutis benigna and acrodermatitis chronica atrophicans (aca) have been well known in europe for a long time as skin diseases induced by tickbites. earlier hints that these inflammatory dermatoses and associated disorders (erythema migrans disease) might be of spirochetal origin are now supported by the findings of several groups in the usa and europe. in the united states the endemic occurrence of a new inflammatory disease which seems to be closely ...19846519987
infection of syrian hamsters with lyme disease spirochetes.syrian hamsters were shown to be susceptible to infection by the lyme disease spirochete borrelia burgdorferi. although these spirochetes did not cause any outward signs of illness in these animals, they did cause a generalized infection. spirochetemia was present during the first 6 days of infection. at 14 days postinfection, spirochetes could be isolated from one or more of the following organs: spleen, eyes, kidneys, liver, testes, and brain. spirochetes were isolated from the eyes and kidney ...19846520220
[lyme disease with av-block in a woman after walking in the woods]. 19846521574
[tick-borne spirochaetales infection of lyme (lyme disease)]. 19846533687
european erythema migrans disease and related disorders.european erythema migrans disease, lymphocytoma, and acrodermatitis chronica are a group of disorders associated with the bite of ixodid ticks. these disorders are now thought to be due to a single, or closely related, ixodid tick spirochetes. european erythema migrans disease closely resembles lyme disease. serological evaluation may help to separate spirochetal lymphocytoma from other pseudolymphomas of nonspirochetal origin and from lymphoma. acrodermatitis chronica atrophicans, so far observ ...20176549090
infections acquired in the fields and forests of the united states.sportsmen, backpackers, and outdoor workers may present with unusual infections acquired in the fields and forests of the united states. infections to be considered in such persons with a febrile illness include rocky mountain spotted fever, colorado spotted tick fever, babesiosis, borreliosis, and lyme disease. the differential diagnoses for clinical presentations of pulmonary and gastrointestinal disease are also discussed.19846549506
lyme disease: a new entity. 19836573608
hla-dr in meningopolyneuritis of garin-bujadoux-bannwarth: contrast to lyme disease?sixteen patients with meningopolyneuritis of garin-bujadoux-bannwarth (mpn-gbb) were examined for hla-dr antigens. in contrast to data in lyme disease (ld), which is caused by an identical or closely related spirochete, no significant association was found between the neurological disease and hla-dr. the reported association between neurological disease and hla-dr2 in ld may be due to the inclusion of cases with neurological disease and arthritis, since chronic arthritis in ld seems to be well c ...19846596406
lyme disease in northern california.lyme disease is a recently described clinical entity with cutaneous, neurologic, articular and cardiac manifestations. since the original description of the disease in 1977, more than 500 cases have been reported. although the vast majority of patients have been from the area near lyme, connecticut, we have seen four patients from northern california with various aspects of lyme disease. this diagnosis should be considered in patients who have traveled to tick regions and who have a distinctive ...19836636745
[lyme disease: a new infectious disease]. 19836656464
[the spirochetal etiology of erythema chronicum migrans and of meningo-polyneuritis garin-bujadoux-bannwarth].erythema chronicum migrans and tick-borne meningo-polyneuritis garin-bujadoux-bannwarth are caused by a spirochete transmitted by ixodes ricinus. the same is true for lyme disease, which is the erythema chronicum migrans infection of north-america transmitted by ticks of the same genus. in europe, this etiology is indicated by demonstration of igg and igm antibodies against borrelia duttoni during the course of infection and by immunofluorescence staining of spirochetes in ticks at sites of infe ...19836659638
"endotoxicity" of the lyme disease spirochete. 19836668073
simultaneous occurrence of babesiosis and lyme disease. 19836682178
lymphocytic meningoradiculitis in the united states.lymphocytic meningoradiculitis (bannwarth's syndrome) is a radicular neuralgia associated with a chronic lymphocytic pleocytosis in cerebrospinal fluid and frequently with unilateral or bilateral peripheral facial weakness. most reported cases have occurred during the summer among adults living in central europe. lymphocytic meningoradiculitis has occurred in the united states in a few patients with lyme disease and erythema chronicum migrans. however, it may occur independently. we describe a w ...19836685240
parasitism by ixodes dammini (acari: ixodidae) and antibodies to spirochetes in mammals at lyme disease foci in connecticut, usa. 19846694176
suppression of human lymphocyte responses by oral spirochetes: a monocyte-dependent phenomenon.spirochetes have been implicated in the pathogenesis of several human infections including syphilis, yaws, lyme disease, and periodontal diseases. we examined soluble sonic extracts of oral spirochetes (treponema denticola and t. vincentii) for their ability to alter human lymphocyte function. these organisms were isolated from subgingival plaque of patients with periodontitis. we found that sonicates of several but not all strains of t. denticola caused a dose-dependent inhibition of human lymp ...19846699406
clinical manifestations and descriptive epidemiology of lyme disease in new jersey, 1978 to 1982.clinical manifestations and epidemiologic characteristics of 117 cases (31 children and 86 adults) of lyme disease in new jersey from 1978 to 1982 are summarized. the male-female sex ratio was 1.9:1. an endemic focus in monmouth county has been recognized. erythema chronicum migrans was present in 93% of cases and was the only clinical manifestation in 25% of patients. nonspecific febrile syndrome, in addition to erythema chronicum migrans, was present in 45% of cases; 26% had arthritis. the pro ...19846708273
amblyomma americanum: a potential vector of lyme disease in new jersey.amblyomma americanum is a likely secondary vector of lyme disease in new jersey. ticks of this species were removed from the site of the characteristic skin lesion known as erythema chronicum migrans on two patients with the disease, and the lyme disease spirochete was isolated from nymphs and adults of this species. that a. americanum is a potential vector is supported by its similarities to ixodes dammini, the known tick vector, in seasonal distribution and host utilization. the extensive rang ...19846710158
lyme disease.lyme disease is a newly recognized disease with diverse but characteristic inflammatory manifestations that involve the skin, joints, heart, and cns. the illness develops following the bite of the ixodes tick and is caused by a treponema-like spirochete. this article reviews the causal, epidemiologic, clinical, and laboratory features of this illness. since a large number of patients described with this treatable disease have been children and the disease may be confused with other more serious ...19846711502
histologic demonstration of intradermal spirochetes in a patient with lyme disease.spirochetal organisms were demonstrated histologically in skin biopsy specimens from a patient with lyme disease and erythema chronicum migrans. the patient responded rapidly to penicillin g benzathine administration. convalescent serum contained a high titer of antibody to an lxodes dammini spirochete antigen. the finding of spirochetes in an erythema chronicum migrans lesion in a patient with clinical lyme disease supports further recent evidence that this illness is an infectious disease caus ...20046711586
antibodies to spirochetes in white-tailed deer and prevalence of infected ticks from foci of lyme disease in connecticut.white-tailed deer (odocoileus virginianus) were examined for the tick, ixodes dammini, and sera were analyzed for antibodies to spirochetes during 1982. of the 323 animals inspected in four areas endemic for lyme disease, 188 (58%) had adult ticks; parasitism ranged from 43% at haddam to 82% at east lyme. direct and indirect fluorescent antibody tests detected spirochetes in 18 of 133 (14%) ticks. indirect immunofluorescence tests revealed antibodies at titers of 1:64-1:4,096 to this bacterium i ...19846716556
leads from the mmwr. update: lyme disease--united states. 19846716612
[tick-borne meningoradiculitis--a form of spirochetosis].three pediatric cases of tick-borne meningoradiculitis are presented. this disease is characterized by a distinct sequence of symptoms: erythema chronicum migrans, localized pain, and eventually radicular asymmetric neurologic involvement (in particular facial palsy) associated with findings of aseptic meningitis. on the basis of specific serologic data in these three patients, it is suggested that the etiology of tick-borne meningoradiculitis is also spirochetal , as recently shown for the tick ...19846729423
variation in a major surface protein of lyme disease spirochetes.two monoclonal antibodies (h6831 and h5ts) differed in their indirect immunofluorescence reactivity when tested against 14 strains of lyme disease spirochetes. strains were bound by both antibodies, by h6831 or h5ts alone, or by neither. western blot and immunoprecipitation studies revealed that the determinants of both antibodies were associated with abundant proteins with apparent subunit molecular weights of ca. 34,000 (34k-range proteins). the following results indicated that the 34k-range p ...19846735474
lyme disease. 19846741124
spirochete-associated arthritis (lyme disease) in a dog. 19846746395
lyme disease--united states, 1980. 19816793824
spirochete isolated in tick vectors of lyme disease. 19826807821
lyme disease. 19826815444
the spirochetal etiology of lyme disease.we recovered a newly recognized spirochete from the blood, skin lesions (erythema chronicum migrans [ecm]), or cerebrospinal fluid of 3 of 56 patients with lyme disease and from 21 of 110 nymphal or adult lxodes dammini ticks in connecticut. these isolates and the original one from l. dammini appeared to have the same morphologic and immunologic features. in patients, specific igm antibody titers usually reached a peak between the third and sixth week after the onset of disease; specific igg ant ...19836828118
spirochetes isolated from the blood of two patients with lyme disease.we isolated spirochetes from the blood of 2 of 36 patients in long island and westchester county, new york, who had signs and symptoms suggestive of lyme disease. the spirochetes were morphologically similar and serologically identical to organisms recently found to infect lxodes dammini ticks, which are endemic to the area and have been epidemiologically implicated as vectors of lyme disease. in both patients, there was a rise in specific antispirochetal antibodies in paired specimens of serum. ...19836828119
lyme disease--success for academia and the community. 19836828125
natural distribution of the ixodes dammini spirochete.spirochetes believed to be the cause of lyme disease were isolated from white-footed mice and white-tailed deer, the preferred natural hosts of ixodes dammini, the tick vector. evidence suggests that deer act as a reservoir of the disease and provide an overwintering mechanism for both spirochetes and adult ticks. some tick larvae may acquire the spirochete by transovarial passage and the nymphal stage may transmit the disease to humans.19836836274
[chronic erythema migrans and tick-transmitted meningopolyneuritis (garin-bujadoux-bannwarth): borrelia infections?].antibodies against borrelia duttoni using indirect immunofluorescence could be demonstrated in 6 patients with erythema chronicum migrans and in 8 persons with tick-borne meningopolyneuritis. significant increases of igg and igm antibody titres in the course of the disease and igg antibodies in the csf indicate recent contact with borrelia duttoni or a closely related agent. demonstration by fluorescence serology of spirochaetaceae in ixodes ricinus in two sites of infection equally indicate suc ...19836839977
bacteriophage in the ixodes dammini spirochete, etiological agent of lyme disease.a bacteriophage with a b-3 morphology was detected by electron microscopy in a spirochete isolated from the tick ixodes dammini. it has a 40- to 50-nm elongated head and a tail 50 to 70 nm in length. it appears devoid of collars or kite-tail structure. the spirochete has been identified as the causative agent of lyme disease.19836853449
lyme disease in north carolina.we report two cases of lyme disease in north carolina, further expanding the distribution of known sporadic cases of this predominantly northeastern problem in southern states. physicians in areas where lyme disease has traditionally not been recognized should be alerted to its characteristic rash (erythema chronicum migrans), tick vector (ixodes species), possible severe manifestations (neurologic, arthritic, and cardiac), and response to appropriate antibiotic therapy (penicillin or tetracycli ...19836857306
ticks and lyme disease in the united states. 19836859709
the early clinical manifestations of lyme disease.lyme disease, caused by a tick-transmitted spirochete, typically begins with a unique skin lesion, erythema chronicum migrans. of 314 patients with this skin lesion, almost half developed multiple annular secondary lesions; some patients had evanescent red blotches or circles, malar or urticarial rash, conjunctivitis, periorbital edema, or diffuse erythema. skin manifestations were often accompanied by malaise and fatigue, headache, fever and chills, generalized achiness, and regional lymphadeno ...19836859726
[erythema migrans disease. a contribution to its clinical features and relation to lyme disease].a largely prospective study averaging 33 months was undertaken in 30 patients with and one without (chronic) erythema migrans. in one case erythema migrans disappeared spontaneously, in the 29 others it persisted up to six months, but quickly responded to antibiotic treatment. measured from the tick bite in 9 patients or from onset of the erythema migrans, arthritis and arthralgia appeared in ten patients on average 6.5 months (0.7-36), and persisted for eight months (0.2-42). in seven of these ...19836872871
was it lyme disease? 19836880371
spirochetes in ixodes dammini and mammals from connecticut.spirochetes were observed in the midguts of 35% of 147 motile ixodes dammini from three locations in lyme and east haddam, connecticut. positive ticks were removed from eastern chipmunks (tamias striatus), raccoons (procyon lotor), white-footed mice (peromyscus leucopus), and a red squirrel (tamiasciurus hudsonicus). spirochetes were isolated in fortified kelly's medium from nine questing or partially engorged i. dammini adults and nymphs and from the bloods of a raccoon and a white-footed mouse ...19836881431
the spirochete in erythema chronicum migrans. demonstration by light and electron microscopy.a lesion of erythema chronicum migrans was examined by light and electron microscopy. spirochetes were identified by light microscopy with steiner silver stain. electron microscopy was performed on deparaffinized tissue of the biopsy specimen and a spirochete was identified in the tissue. this treponema-like spirochete has morphological characteristics similar to those described previously for spirochetes obtained from ticks in areas endemic for lyme disease.19836881479
[the spirochetal etiology of erythema chronicum migrans and garin-bujadoux-bannwarth meningo-polyneuritis].erythema chronicum migrans and tick-born meningo-polyneuritis garin-bujadoux-bannwarth are caused by a spirochete transmitted by ixodes ricinus. the same is true of lyme disease, the erythema chronicum migrans infection of north america transmitted by ticks of the same genus. in europe demonstration of igg and igm antibodies against borrelia duttoni during the course of infection and by immunofluorescence staining of spirochetes in ticks at sites of infection indicate this etiology. in the usa a ...19836884950
demyelinating neuropathy accompanying lyme disease. 19826890169
a case of "lyme disease" acquired in new jersey. 19816942167
lyme disease in new jersey: a cluster of 4 cases and 13 sporadic cases. 19826956739
antibiotic therapy in lyme disease.we studied antibiotic efficacy in 113 patients with erythema chronicum migrans, the first manifestation of lyme disease. erythema chronicum migrans and its associated symptoms resolved faster in patients given penicillin or tetracycline (median duration, 4 and 2 days, respectively) than in untreated patients (10 days; p less than 0.001 and p = 0.005, respectively). erythromycin had no significant effect. although the frequency of subsequent neurologic and cardiac abnormalities was similar in all ...19806967272
lyme carditis: cardiac abnormalities of lyme disease.we studied 20 patients, mostly young adult men, with cardiac involvement of lyme disease. the commonest abnormality (18 patients) was fluctuating degrees of atrioventricular block; eight of them developed complete heart block. thirteen patients had evidence of more diffuse cardiac involvement: electrocardiographic changes compatible with acute myopericarditis (11 patients), radionuclide evidence of mild left ventricular dysfunction (five of 12 patients tested), or frank cardiomegaly (one patient ...19806967274
lyme disease-a tick-borne spirochetosis?a treponema-like spirochete was detected in and isolated from adult ixodes dammini, the incriminated tick vector of lyme disease. causally related to the spirochetes may be long-lasting cutaneous lesions that appeared on new zealand white rabbits 10 to 12 weeks after infected ticks fed on them. samples of serum from patients with lyme disease were shown by indirect immunofluorescence to contain antibodies to this agent. it is suggested that the newly discovered spirochete is involved in the etio ...19827043737
lyme disease: additional evidence of widespread distribution. recognition of a tick-borne dermatitis-encephalitis-arthritis syndrome in an area of known ixodes tick distribution.lyme disease is a process of unknown etiology that has been linked to bites of ticks of the ixodes ricinus complex. central minnesota is an area of known ixodes dammini distribution. this case represents the first recognition of lyme disease from this area. this case presented as a fluctuating meningoencephalitis with superimposed cranial neuropathy. the characteristic skin lesion, erythema chronicum migrans, was recognized by history, and oligoarticular arthritis subsequently developed. physici ...19827072749
lyme disease and erythema chronicum migrans in minnesota. 19827078540
lyme disease. 19827081002
lyme disease first observed to be aseptic meningitis. 19827081166
lyme disease: spirochetes up to old ticks? 19827097930
Refresh
firstprev
...21222324252627282930...
nextlast
Displaying items 2001 - 2100 of 15661