Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| activator-sigma interaction: a hydrophobic segment mediates the interaction of a sigma family promoter recognition protein with a sliding clamp transcription activator. | activation of transcription at bacteriophage t4 late promoters and coupling of late transcription to concurrent replication requires a peculiar transcriptional activator, the gp45 sliding clamp of the t4 dna polymerase. in order to activate transcription, the topologically dna-linked trimeric gp45 must interact with two t4-encoded rna polymerase-binding proteins, the gp33 co-activator, and the gp55 late sigma factor. the carboxy termini of gp55 and gp33 share a similar sequence, which has been s ... | 1998 | 9813112 |
| cloning and sequencing of major capsid protein (mcp) gene of a vibriophage, kvp20, possibly related to t-even coliphages. | a large, tailed, prolate-headed vibriophage designated kvp20 was isolated from seawater. kvp20 was morphologically very similar to the previously described vibriophage, kvp40 (matsuzaki, s., inoue, t., tanaka, s., 1998. virology, 242, 314-318). however, they showed entirely different host specificities and could easily be differentiated from each other by their patterns of dna restriction fragments. the major capsid protein (mcp) gene of kvp20 encoding the precursor of major capsid protein (pro- ... | 1998 | 9813227 |
| suppressive therapy with levothyroxine for solitary thyroid nodules: a double-blind controlled clinical study and cumulative meta-analyses. | levothyroxine suppressive treatment of solitary thyroid nodules is controversial. a 1-yr prospective randomized placebo-controlled trial was conducted to evaluate the effect of t4 on nodule volume and bone mineral density, and meta-analyses were performed to examine the quantitative synthesis of data from similar designed controlled trials. forty-five euthyroid patients (42 females, age range: 19-73 yr) with single, colloid nodules were randomized to t4 (21 patients, 2.7 +/- 0.3 microg/kg, tsh < ... | 1998 | 9814462 |
| minimally invasive coronary surgery: surgical considerations and assessment of cardiac troponin i. | minimally invasive coronary artery bypass grafting (micabg) using internal thoracic artery (ita) without median sternotomy and cardiopulmonary bypass (cpb) become a viable option for the management of proximal left anterior descending artery (lad) disease. recent studies have demonstrated that cardiac troponine i (ctni), a new highly specific diagnostic marker of cardiomyocyte damage, is a reliable marker of cardiac ischemia during heart operations under cpb. | 1998 | 9814799 |
| na+-k+-cl- cotransport in human fibroblasts is inhibited by cytomegalovirus infection. | we examined the effects of human cytomegalovirus (hcmv) infection on the na+-k+-cl- cotransporter (nkcc) in a human fibroblast cell line. using the cl--sensitive dye mqae, we showed that the mock-infected mrc-5 cells express a functional nkcc. 1) intracellular cl- concentration ([cl-]i) was significantly reduced from 53.4 +/- 3.4 mm to 35.1 +/- 3.6 mm following bumetanide treatment. 2) net cl- efflux caused by replacement of external cl- with gluconate was bumetanide sensitive. 3) in cl--deplete ... | 1998 | 9814982 |
| prediction of response to neoadjuvant chemoendocrine therapy in primary breast carcinomas. | our aim was to determine whether biological molecular markers can predict response to neoadjuvant chemoendocrine therapy in patients with early breast cancer. ninety patients (median age 56 years; range, 28-69 years) with primary operable breast carcinoma were studied. they were treated with four 3-weekly cycles of chemotherapy with mitozantrone, methotrexate (+/- mitomycin c), and tamoxifen prior to surgery. fine-needle aspiration was used to obtain samples from patients prior to therapy, and t ... | 1997 | 9815725 |
| bladder tissue pharmacokinetics and antitumor effect of intravesical 5-fluorouridine. | the present study evaluates whether intravesical 5-fluorouridine (fur), a potent fluorinated pyrimidine, is effective against bladder cancer. the tissue and plasma pharmacokinetics of i.v. and intravesical fur were studied in dogs to determine the tissue targeting advantage by the intravesical route. the i.v. study used a bolus fur dose of 4 mg/kg, which is tolerated in humans. the disposition of fur was biphasic, with a peak concentration of 8.8 microgram/ml and a clearance of 127 ml/min/kg. 5- ... | 1997 | 9815765 |
| mrp and mdr1 gene expression in primary breast carcinomas. | to evaluate the clinically important mechanisms of drug resistance in breast cancer, the expression of the mrp gene and the corresponding one for the mdr1 gene were determined in primary breast carcinoma specimens by both reverse transcription-pcr (n = 134) and immunohistochemistry (n = 63). expression of mrp rna was observed in all breast cancer specimens. mdr1 rna was detected in 80 (60%) of the carcinomas. staining with monoclonal antibodies qcrl-1 and qcrl-3, which both recognize mrp, was st ... | 1996 | 9816292 |
| pharmacodynamics of doxorubicin in human bladder tumors. | intravesical doxorubicin treatment delivers high drug concentrations to the bladder wall, yet the treatment produces only a variable and incomplete response in superficial bladder cancer and insignificant activity in muscle-invading disease. this study evaluated the pharmacological basis for the clinical observations and potential prognostic indicators of tumor sensitivity to doxorubicin. the pharmacodynamics of doxorubicin were studied using histocultures of surgical specimens of seven superfic ... | 1996 | 9816297 |
| surgical salvage after failed radiation for paranasal sinus malignancy. | to comment on the role of surgical salvage following failed initial treatment for paranasal sinus malignancy. | 1998 | 9818815 |
| identification and characterization of the fourth single-stranded-dna binding domain of replication protein a. | replication protein a (rpa), the heterotrimeric single-stranded-dna (ssdna) binding protein (ssb) of eukaryotes, contains two homologous ssdna binding domains (a and b) in its largest subunit, rpa1, and a third domain in its second-largest subunit, rpa2. here we report that saccharomyces cerevisiae rpa1 contains a previously undetected ssdna binding domain (domain c) lying in tandem with domains a and b. the carboxy-terminal portion of domain c shows sequence similarity to domains a and b and to ... | 1998 | 9819409 |
| contribution of 3,5,3'-tri-iodothyronine produced locally from thyroxine in several maternal tissues of the near-term pregnant rat. | 3,5, 3'-tri-iodothyronine(t3)is produced by the thyroid and locally, by monodeiodination of thyroxine (t4), in the peripheral tissues. during pregnancy the thyroid hormone status in rats is altered: plasma and tissue levels of t4 and t3 are decreased. we investigated the effects of pregnancy on the contribution of t3 produced locally in the maternal tissues by administering a continuous infusion of [125i]t4 and [131i]t3. the transport of t4 to almost all maternal organs diminished. less t was tr ... | 1998 | 9820624 |
| seasonal regulation of prolactin secretion in hypophyseal stalk transected beef calves. | seasonal regulation of prolactin secretion was investigated in crossbred beef heifer calves. calves were randomly assigned to hypophyseal stalk transection (hst, n = 6) or sham-operation control (soc, n = 6) groups and fitted 1 day before surgery with an indwelling external jugular catheter. prolactin (prl), growth hormone (gh), thyroid stimulating hormone (tsh), thyroxine (t4), and tri-iodothyronine (t3) in peripheral serum were measured by radioimmunoassay in samples obtained before and after ... | 1998 | 9821500 |
| the role of mutation frequency decline and sos repair systems in methyl methanesulfonate mutagenesis. | methyl methanesulfonate (mms) is an sn2 type alkylating agent which predominantly methylates nitrogen atoms in purines. among the methylated bases 3mea and 3meg are highly mutagenic and toxic. the excision of these lesions leads to the formation of apurinic (ap) sites and subsequently to at-->ta or gc-->ta transversions. the in vivo method based on phenotypic analysis of arg+ revertants of escherichia coli k12 and sensitivity to t4 nonsense mutants has been used to estimate the specificity of mm ... | 1998 | 9821881 |
| the effect of lumbar epidural anesthesia on maternal middle cerebral artery blood flow in normal pregnancy: a prospective, randomized, double-blind comparison study. | lumbar epidural anesthesia is associated with a transient elevation in intracranial pressure in both animals and humans and decreased cerebral blood flow in animals. we sought to determine the effect of medium-onset and slow-onset local anesthetic lumbar epidural anesthesia on maternal cerebral blood flow in normal human pregnancy. | 1998 | 9822508 |
| incidence of port site recurrence after laparoscopic cholecystectomy for preoperatively unsuspected gallbladder carcinoma. | we sought to determine the incidence of recurrence of carcinoma at the port site and the outcome of patients with such recurrences after exploratory laparoscopy/laparoscopic cholecystectomy for unsuspected gallbladder carcinoma and analyzed aspects of the laparoscopic procedure associated with recurrences at the port site. | 1998 | 9823395 |
| resympathectomy for palmar and axillary hyperhidrosis. | the aim was to analyse patterns of failure or symptom recurrence after primary sympathectomy for palmar or axillary hyperhidrosis, and to carry out tactical problem-solving for resympathectomy and review the operative findings. | 1998 | 9823911 |
| intrapulmonary satellite nodule of lung cancer as a t factor. | we conducted a validation of the treatment of satellite nodules in the uicc tnm classification of 1993 and 1997. | 1998 | 9824006 |
| determination of thyroxine in the hair of newborns by radioimmunoassay with high-performance liquid chromatographic confirmation. | hair analysis is often used in forensic toxicology to study, retrospectively, chronic exposure of individuals to drugs, and consequently newborn hair may become an ideal sample to study intrauterine exposure to xenobiotics as well as to endogenous compounds. as a tool to investigate a supposed maternal thyroxine (t4) supply to the congenital hypothyroid fetus, we devised to use the analysis of t4 extracted from newborn hair. in the present paper, the analytical method based on t4 extraction from ... | 1998 | 9824220 |
| thyroid function in lead smelter workers: absence of subacute or cumulative effects with moderate lead burdens. | to evaluate the effect of low to moderate occupational lead exposure on thyroid function we conducted a cross-sectional study of 151 male lead smelter workers. | 1998 | 9826077 |
| the bacteriophage t4 dna packaging apparatus targets the unexpanded prohead. | during the morphogenesis of the bacteriophage t4 capsid, a conformational change of the major head shell protein, gene product (gp) 23, causes a 50% increase in capsid volume. this expansion is required to accept the full length chromosome and, therefore, must precede the completion of packaging. the expanded shell is thinner and more stable than its precursor, and can bind accessory proteins which further stabilize it. in phages lambda, t3, t7 and p22, expansion occurs during dna packaging. how ... | 1998 | 9826505 |
| capsid expansion follows the initiation of dna packaging in bacteriophage t4. | most bacteriophages undergo a dramatic expansion of their capsids during morphogenesis. in phages lambda, t3, t7 and p22, it has been shown that expansion occurs during the packaging of dna into the capsid. the terminase-dna complex docks with the portal vertex of an unexpanded prohead and begins packaging. after some of the dna has entered, the major head protein undergoes a conformational change that increases both the volume and stability of the capsid. in phage t4, the link between packaging ... | 1998 | 9826506 |
| tsh and thyroid hormones induce the release of secretory granules in the harderian gland of hypophysectomized frogs, (rana esculenta): morphological observations. | the secretory activity of the harderian gland (hg) in the frog rana esculenta is influenced by pituitary and thyroid hormones. administration of thyroid stimulating hormone (tsh), t3 and t4 to hypophysectomized male and female frogs, affects the release of secretory granules in the lumina of glandular acini. in particular, treatment with t3 radically modified morphological parameters (height and area of acinar lumina of the glandular cells); t4 or tsh had less effect. administration of thiouraci ... | 1998 | 9827054 |
| sulfation of thyroid hormones by liver of rainbow trout, oncorhynchus mykiss. | we studied hepatic sulfation of thyroid hormones (th) in rainbow trout, oncorhynchus mykiss. sulfation of thyroxine (t4) and 3,5,3'-triiodothyronine (t3) was detected in the cytosolic (63-67%), microsomal (12-16%), nuclear (12-14%) and mitochondrial/lysosomal (7-8%) fractions. using 3'-phosphoadenosine 5'-phosphosulfate (paps) as a sulfate donor, sulfation of t4 and t3 by the cytosolic fraction depended on protein concentration and time. the ph profiles for t4- and t3-sulfation were broad and ov ... | 1998 | 9827058 |
| [non-thyroid indications of treatment with thyroid hormones]. | introduction: the use of thyroid hormone is currently strictly limited to thyroid diseases. several recent papers have examined the effects of thyroid hormone in non-thyroidal diseases. these studies examined either the use of the pharmacological properties of thyroid hormone or the effect of the correction of the decrease in triiodothyronine (t3) associated with non-thyroid illnesses. current knowledge and key points: intravenous administration of t3 improves the cardiac index during ongoing ca ... | 1998 | 9827444 |
| inhibitory action of oral thyrotropin-releasing hormone on the glucoregulatory response of the oral glucose tolerance test. | thyrotropin-releasing hormone (trh) has been found in the gastrointestinal tract, where it mainly exerts an inhibitory action. we used oral trh, a stable and powerful formulation, to explore the glucoregulatory response of oral glucose tolerance test (ogtt) on obese patients with impaired glucose tolerance (igt). seven obese patients with igt and eight controls were investigated. three tests were performed on three separate days. on day 1, an oral trh test: a 40 mg trh tablet, was given. blood s ... | 1998 | 9827661 |
| the thyroid axis and depression. | hypothyroidism may give rise to frank depression that usually responds to thyroxine therapy. depressed subjects with subclinical hypothyroidism and/or autoimmune thyroiditis should probably also be treated similarly. most patients with depression, although generally viewed as chemically euthyroid, have alterations in their thyroid function including slight elevation of the serum thyroxine (t4), blunted thyrotropin (tsh) response to thyrotropin-releasing hormone (trh) stimulation, and loss of the ... | 1998 | 9827665 |
| novel hepatoselective insulin analogues: studies with covalently linked thyroxyl-insulin complexes. | to explore the possibility that insulin analogues designed to have restricted access to peripheral tissues may display relative hepatoselectivity in vivo, nalphabeta1-thyroxyl-insulin (b1-t4-ins) and nalphabeta1-thyroxyl-aminohexanoyl insulin (b1-t4-aha-ins) were synthesized. these insulin analogues bind thyroid hormone binding proteins to form high molecular weight complexes. effects of intravenous infusions of b1-t4-ins; b1-t4-aha-ins; combined thyroxine binding globulin (tbg) and b1-t4-ins an ... | 1998 | 9827847 |
| monitoring metal ion flux in reactions of metallothionein and drug-modified metallothionein by electrospray mass spectrometry. | the capabilities of electrospray ionization mass spectrometry are demonstrated for monitoring the flux of metal ions out of and into the metalloprotein rabbit liver metallothionein and, in one example, chlorambucil-alkylated metallothionein. metal ion transfers may be followed as the reactions proceed in situ to provide kinetic information. more uniquely to this technique, metal ion stoichiometries may be determined for reaction intermediates and products. partners used in these studies include ... | 1998 | 9828006 |
| postnatal exposure to chlorinated dioxins and related chemicals on thyroid hormone status in japanese breast-fed infants. | effects of postnatal exposure to polychlorinated dibenzo-p-dioxins (pcdds), polychlorinated dibenzofurans (pcdfs) and coplanar polychlorinated biphenyls (co-pcbs) on thyroid hormone status were studied in the peripheral blood of 36 breast-fed japanese infants. estimated total intakes of these chemicals in toxic equivalent quantity (teq) converted into 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-tcdd) from the breast milk significantly and negatively correlated with the levels of triiodothyronin ... | 1998 | 9828307 |
| change in serum thyroid-stimulating hormone concentration in response to administration of thyrotropin-releasing hormone to healthy dogs, hypothyroid dogs, and euthyroid dogs with concurrent disease. | to determine whether measuring change in serum thyroid-stimulating hormone (tsh) concentration in response to thyrotropin-releasing hormone (trh) administration can be used as a test of thyroid function in dogs suspected of having hypothyroidism. | 1998 | 9828939 |
| clinical and molecular characterization of a brazilian patient with pit-1 deficiency. | we studied a 14 year-old girl with extreme short stature (-9.5 sds), normal psychomotor development and signs of progressive hypothyroidism. basal igf-i and t4 were low. serum gh was low after insulin-induced hypoglycemia and gh-releasing hormone administration. both tsh and prolactin were low and did not rise after trh administration. gonadotropins were normal and cortisol levels were elevated. in contrast, dhea-s levels were low and she did not develop pubic hair until 26 years of age, compati ... | 1998 | 9829213 |
| prognostic implications of pulmonary satellite nodules: are the 1997 staging revisions appropriate? | in the 1992 ajcc and 1993 uicc staging systems, primary lobe satellite nodules increased the t designation of the primary by one level and ipsilateral non-primary lobe satellite nodules raised the t designation to t4. the recent 1997 uicc and ajcc staging revisions assign a t4 (iiib) designation to satellite nodules in a primary lobe, and a m1 (iv) designation to satellites in ipsilateral non-primary lobes. there is abundant evidence showing that satellite nodules are negative prognostic factors ... | 1998 | 9829541 |
| [phase ii study on preoperative radio-chemo-thermotherapy in locally advanced rectal carcinoma]. | recent studies show that preoperative radio-chemotherapy can increase resectability and local control of locally advanced rectal carcinomas. additional regional hyperthermia might increase remission rates and tumor response. we therefore tested regional hyperthermia together with radio-chemotherapy in a phase-ii study on locally advanced rectal carcinomas. | 1998 | 9830436 |
| [treatment of basedow-graves' hyperthyroidism: retrospective analysis after 30 years]. | it is still debated which is the best treatment for basedow-graves' hyperthyroidism (bgh). we reviewed 195 patients treated and followed-up during the past 30 years: 88 treated with propylthiouracil (ptu), 70 with 131i and 37 thyroidectomized. | 1998 | 9830747 |
| studies of the hormonal regulation of type 2 5'-iodothyronine deiodinase messenger ribonucleic acid in pituitary tumor cells using semiquantitative reverse transcription-polymerase chain reaction. | we developed a sensitive competitive rt-pcr technique for quantitating the ratio of d2 to cyclophilin messenger rna (mrna) and used this to study type 2 deiodinase (d2) mrna regulation. hyperthyroidism in rats causes a 2- to 3-fold reduction in anterior pituitary and medial basal hypothalamus (mbh). thyroid hormone (t3) withdrawal increased the d2/cyclophilin ratio 2- to 3-fold over 48 h in both gc and gh4c1 cells. t3 additional reduced d2 gene transcription by 50% over 2 h and about 30% over th ... | 1998 | 9832426 |
| surgery for thoracic esophageal carcinoma with clinically positive cervical nodes. | we attempted to determine whether and under what circumstances surgical intervention should be recommended for patients with clinically positive cervical nodes for metastasis from thoracic esophageal carcinoma by pretreatment examination. | 1998 | 9832686 |
| cell proliferation and apoptosis of thyroid follicular cells are involved in the involution of experimental non-tumoral hyperplastic goiter. | to assess the involvement of cellular inhibition and the appearance of apoptosis in regression of the hyperplastic thyroid gland towards normality, an experimental design was used to elicit non-toxic goiter by inducing hyperplastic goiter in rats by treatment with methimazole. we performed a morphological and pcna immunocytochemical study together with in situ end labelling with bromodeoxyuridine in thyroid glands of rats receiving methimazole in their drinking water over 21 days after which the ... | 1998 | 9833684 |
| human electroencephalographic (eeg) response to olfactory stimulation: two experiments using the aroma of food. | the present studies sought to examine the effect of olfactory stimulation on human central nervous system activity. in the first experiment (n = 21), eeg response to the 'synthetic' odours of chocolate, spearmint, almond, strawberry, vegetable, garlic and onion, and cumin or no odour was recorded from 19 electrodes (f3, f4, f7, f8, fz, t3, t4, t5, t6, p3, p4, pz, o1, o2, c3, c4, cz) in all eeg frequencies (delta, theta, alpha, beta1 and beta2). exposure to the odour of chocolate was associated w ... | 1998 | 9834885 |
| [influence of neoadjuvant treatment on bladder infiltrating tumors treated with radical cystectomy]. | retrospective study of 107 patients diagnosed with infiltrant tumour of the bladder in stage t3-t4 n0-n1, treated with radical surgery. eighty-four (84) received neoadjuvant therapy with radio- and/or chemotherapy. the neoadjuvant treatment was seen to provide significantly better survival, but the specific type of neoadjuvant treatment appears to have no influence. the multivariate study evidenced that the two most influential variables for survival are the complementary treatment and the clini ... | 1998 | 9835083 |
| nasopharyngeal carcinoma in childhood and adolescence. | this study reviews the authors' experience from 1979 through 1996 in the management and outcome of 56 patients with nasopharyngeal carcinoma who were under 20 years of age. | 1998 | 9835902 |
| apnea following spinal anaesthesia in two former pre-term infants. | to report the occurrence of apnea and bradycardia in two former pre-term infants who received spinal anaesthesia without inhalational or intravenous anaesthetic agents during inguinal herniorrhaphy. | 1998 | 9836035 |
| physiological regulation of hypothalamic trh transcription in vivo is t3 receptor isoform specific. | thyroid hormone (tri-iodo-thyronine, t3) exerts transcriptional effects on target genes in responsive cells. these effects are determined by dna/protein interactions governed by the type of t3 receptors (trs) in the cell. as trs show tissue and developmental variations, regulation is best addressed in an integrated in vivo model. we examined tr subtype effects on thyrotropin-releasing hormone (trh) transcription and on the pituitary/thyroid axis end point: thyroid hormone secretion. polyethyleni ... | 1998 | 9837866 |
| [analysis of 33 patients with nasopharyngeal carcinoma--surgical management for persistent tumor after radiation therapy]. | we report thirty-three patients treated for nasopharyngeal carcinoma (npc) in our clinic from 1976 to 1997. they consisted of 24 males and 9 females, and their ages ranged from 17 to 76 years with an average of 56 years. fourteen patients initially presented with ear symptoms due to tubal insufficiency, 11 with cervical lymphadenopathy, 6 with nasal symptoms and 4 with cranial nerve paralysis. the mean interval from the onset of their complaints to the time of difinite diagnosis of npc was 5.8 m ... | 1998 | 9838791 |
| [clinical study of hypopharyngeal carcinoma]. | a clinical study was performed of 83 patients with hypopharyngeal cancer treated in the sapporo medical university hospital from 1982 to 1995. five-year cumulative survival rate was 34.9% in the whole group and 37.2% in the radical surgical and/or radiation treatment group. in the radiation treatment group, the patients with t1, t2, n0 or n1 stage disease, especially those whose original disease responded almost completely to 40gy irradiation, showed high tumor control rates following full-dose ... | 1998 | 9838796 |
| alkaline heating of canola and rapeseed meals reduces toxicity for chicks. | a simple method for improving the nutritive quality of canola and high glucosinolate rapeseed meals for monogastric animals (chicks) was developed; the meals were mixed with nahco3 and nh4hco3, then heated in a conventional oven. chicks fed untreated canola or rapeseed meals gained less weight than those fed a soybean meal diet, whereas chicks fed the alkaline-heated meals had weight gains not significantly different than those fed the soybean diet. the antithyroid effect of the untreated rapese ... | 1998 | 9839830 |
| staging of oesophageal carcinoma with high resolution endoluminal ultrasonography. | oesophageal carcinoma is a disease with poor prognosis despite improved treatment and diagnostic methods. the most important prognostic features are the degree of wall invasion and the presence of lymph node metastasis. endoscopic ultrasonography (eus) in the region of 7.5-12 mhz has improved the accuracy of tumour staging. in the course of 1 year, 21 patients with oesophageal carcinoma were examined with 20 mhz high-resolution intraluminal ultrasonography (hres). in 11 (52%) patients, both ultr ... | 1998 | 9840517 |
| reciprocal interactions between beta1-integrin and epidermal growth factor receptor in three-dimensional basement membrane breast cultures: a different perspective in epithelial biology. | anchorage and growth factor independence are cardinal features of the transformed phenotype. although it is logical that the two pathways must be coregulated in normal tissues to maintain homeostasis, this has not been demonstrated directly. we showed previously that down-modulation of beta1-integrin signaling reverted the malignant behavior of a human breast tumor cell line (t4-2) derived from phenotypically normal cells (hmt-3522) and led to growth arrest in a three-dimensional (3d) basement m ... | 1998 | 9843973 |
| bacteriophage t4 initiates bidirectional dna replication through a two-step process. | two-dimensional gel analysis of the bacteriophage t4 ori(uvsy) region revealed a novel "comet" on the y arc. this comet contains simple y molecules in which the branch points map to the ori(uvsy) transcript region. the comet depends on the the origin and dna synthesis and is abolished by a mutation that reduces replication without affecting transcription. these results argue that the branched molecules are intermediates in replication initiation. a transcriptional terminator, cloned just downstr ... | 1998 | 9844641 |
| continuous hyperfractionated accelerated radiotherapy with/without mitomycin c in head and neck cancer. | to evaluate the effect of mitomycin c to an accelerated hyperfractionated radiation therapy. the aim was to test a very short schedule with/without mitomycin c (mmc) with conventional fractionation in histologically verified squamous cell carcinoma of the head and neck region. | 1998 | 9845100 |
| concurrent tirapazamine and radiotherapy for advanced head and neck carcinomas: a phase ii study. | to evaluate the efficacy and toxicity of tirapazamine, a hypoxic cytotoxin, combined with conventional radiotherapy (rt) for advanced head and neck carcinomas. | 1998 | 9845102 |
| port site recurrences after laparoscopic surgery. a review. | port site metastasis has been a surprising event after laparoscopic procedures in cancer patients. no clear data exist about this phenomenon. the aim of this study is to summarize current epidemiologic knowledge about the risk of this complication. a review of all case reports about port site recurrences was undertaken. to date, 164 cases of port site metastases after videoscopic procedures have been reported in 90 papers. we found 108 cases of implantation after laparoscopy for digestive tumors ... | 1998 | 9845574 |
| surgical treatment of locally advanced rectal cancer. options and strategies. | the results of surgical treatment of locally advanced rectal cancer with special regard to multivisceral resections and preoperative radiotherapy should be analyzed. | 1998 | 9845611 |
| [ability of erythrocytes to deposit thyroid hormones: regulatory role of physico-chemical factors in vitro]. | data obtained suggest the existence of regulation mechanism controlling parameters of thyroid status, that does not require any modification of thyroid gland secretory function. the realisation of this mechanism can involve hormone-depositing function of blood erythrocytes, which is sensitive to a) change of regional or systemic ph and b) change of hematocrit. results of the present study indicate that mammalian erythrocytes are able to bind considerable quantities of t3 and t4 and, t3 binding i ... | 1998 | 9845926 |
| plasma levels of selenium, selenoprotein p and glutathione peroxidase and their correlations to fish intake and serum levels of thyrotropin and thyroid hormones: a study on latvian fish consumers. | to study the relationships between fish intake and different markers of selenium status and thyroid hormone function. | 1998 | 9846591 |
| continuous hyperfractionated accelerated radiotherapy in advanced head and neck malignancies. | 58 patients of advanced head and neck cancer were treated by continuous hyperfractionated accelerated radiotherapy (study group) or conventional radiotherapy (control group). the study group of 29 patients had 26/29 (89%) of patients of stage t3 and t4 with 12/29 (41% 0) > n2 disease. the schedule employed was 1.5 gy 3 times a day in 36 fractions on 12 treatment days without stopping for weekends. the spinal dose has been kept at 40.5 gy and interfraction interval has been strictly kept at 6 hrs ... | 1998 | 9847466 |
| thyroxine replacement attenuates hypothyroxinemia, hearing loss, and motor deficits following developmental exposure to aroclor 1254 in rats. | the nervous system is dependent upon thyroid hormones for normal development, and we previously reported that developmental aroclor 1254 (a1254) exposure caused hypothyroxinemia, hearing loss and other behavioral changes in rats. (goldey et al., 1995a; herr et al., 1996). the hypothesis that a1254-induced hypothyroxinemia may have contributed to the observed functional changes was tested in primiparous long-evans rats given daily oral doses of corn oil (control) or 8 mg/kg of aroclor 1254 from g ... | 1998 | 9848116 |
| pelvic exenteration for advanced primary rectal cancer in male patients. | between november 1987 and january 1996 pelvic exenteration for primary rectal cancer was carried out in 11 male patients. two underwent a primary resection with subtotal cystectomy. in the remaining nine patients, the treatment commenced with a staging laparotomy and the fashioning of an end colostomy of the descending colon, followed by preoperative radiotherapy (50-56 gy in 5 weeks). total exenteration with uretero-ileo-cutaneostomy was carried out 4-6 weeks later. in two patients, the exenter ... | 1998 | 9848333 |
| thyroid dysfunction and nodular goiter in hemodialysis and peritoneal dialysis patients. | to investigate the prevalence of nodular goiter and thyroid dysfunction in uremic patients undergoing hemodialysis (hd) and peritoneal dialysis. | 1998 | 9848631 |
| neomycin b inhibits splicing of the td intron indirectly by interfering with translation and enhances missplicing in vivo. | the aminoglycoside antibiotic neomycin b inhibits translation in prokaryotes and interferes with rna-protein interactions in hiv both in vivo and in vitro. hitherto, inhibition of ribozyme catalysis has only been observed in vitro. we therefore monitored the activity of neomycin b and several other aminoglycoside antibiotics on splicing of the t4 phage thymidylate synthase (td) intron in vivo. all antibiotics tested inhibited splicing, even chloramphenicol, which does not inhibit splicing in vit ... | 1998 | 9848660 |
| the neuropeptides, vip and npy, that are present in the thyroid nerves are not released into the thyroid vein. | in the present study, we tested the hypothesis that the neuropeptides, vasoactive intestinal peptide (vip) and neuropeptide y (npy), which are present in the thyroid nerves, act as physiological neurotransmitters involved in the regulation of thyroid hormone secretion and thyroid blood flow. specifically, we examined whether these neuropeptides can be released into thyroid blood vessels by electrical stimulation of the major thyroid nerves or whether their expression is altered by changes in iod ... | 1998 | 9848726 |
| thyroxine administration to infants of less than 30 weeks gestational age decreases plasma tri-iodothyronine concentrations. | to investigate the effect on thyroid hormone metabolism of the administration of thyroxine to very preterm infants. | 1998 | 9849815 |
| decrease in plasma levels of vasoactive intestinal polypeptide in short bowel syndrome: experimental study. | to investigate the behaviour of the vasoactive intestinal polypeptide (vip) in short bowel syndrome (sbs), an experimental model of massive intestinal resection (mir) was developed. for this purpose, 20 'minipigs' were divided into two experimental groups: a (control) and b (mir). the parameters determined were the mean plasma levels of vip and the degree of steatorrhea at four different times: t1 (basal), t2 (one week after surgery), t3 (two weeks after surgery), and t4 (24 weeks after surgery) ... | 1998 | 9851334 |
| the prediction of the prognosis for rectal carcinoma down-staged by pre-operative radiotherapy by transrectal ultrasonography. | we attempted to determine whether the results of transrectal ultrasonography (trus) could provide any prognostic information about patients with rectal carcinoma treated with pre-operative radiotherapy (rt). | 1998 | 9851337 |
| molecular diagnosis of residual and recurrent thyroid cancer by amplification of thyroglobulin messenger ribonucleic acid in peripheral blood. | serum thyroglobulin measurement by immunoassay is used to detect residual or recurrent thyroid cancer after thyroid ablation. however, the usefulness of immunoassay is limited by both the requirement for thyroid hormone withdrawal to attain optimal test sensitivity and interference by antithyroglobulin antibodies. to circumvent these problems, we amplified thyroglobulin messenger ribonucleic acid (mrna) in peripheral blood using rt-pcr and compared the accuracy of this test to serum thyroglobuli ... | 1998 | 9851791 |
| abortive initiation of transcription at a hybrid promoter. an analysis of the sliding clamp activator of bacteriophage t4 late transcription, and a comparison of the sigma70 and t4 gp55 promoter recognition proteins. | bacteriophage t4 late promoters are transcribed by an rna polymerase holoenzyme comprising the escherichia coli core, e, the phage gene 55-encoded promoter recognition subunit, gp55, and the gene 33-encoded co-activator, gp33. transcriptional initiation is activated by the t4 gene 45-encoded sliding clamp, which is loaded on to dna at enhancer-like sites by its clamp-loader. correct initiation of transcription at late promoters in basal mode requires only rna polymerase core and gp55 (e.gp55). d ... | 1998 | 9852060 |
| substrate mutations that bypass a specific cpn10 chaperonin requirement for protein folding. | the bacteriophage t4 groes homologue, gp31, in conjunction with the escherichia coli chaperonin groel, is both necessary and sufficient to fold the t4 major capsid protein, gp23, to a state competent for capsid assembly as shown by in vivo expression studies. groes is unable to function in this role as a productive co-chaperonin. the sequencing and characterization of mutations within gp23 that confer groel and gp31 chaperonin-independent folding of the mutant protein suggest that the chaperonin ... | 1998 | 9852065 |
| correlation of activated monocytes or b cells with t lymphocyte subsets in patients with graves' disease. | we analyzed the phenotypic characteristics of pbmc from 34 patients with graves' disease (gd) at different stages of the disease to explore the sequence of immunological events associated with it. in all cases their monocytes were in a state of activation and differentiation more advanced than those of a group of 23 healthy individuals. strikingly, some patients had cd14++dr- immature monocytes, which were absent in healthy individuals. cd14+cd16+drhigh monocytes were more abundant in patients. ... | 1998 | 9852205 |
| metachronous cancer: prognostic factors including prior irradiation. | in this article we evaluate two factors that may be responsible for the reported increased mortality rate in metachronous cancers: prior radiation therapy and stage at presentation. a select group of 358 patients was split into three groups: no prior cancer (group 1), prior cancer treated with radiation therapy (group 2), and prior cancer treated with surgery alone (group 3). we compared survival among the three groups according to stage (t1 or t2 vs. t3 or t4) using the lifetest procedure. surv ... | 1998 | 9852536 |
| segmental specificity of chick sympathetic preganglionic projections is influenced by preganglionic neurons from neighboring spinal cord segments. | sympathetic preganglionic neurons of the chick are located between the brachial and lumbosacral enlargements of the spinal cord. their axons exit the spinal cord via their adjacent ventral roots and project rostrally or caudally along the sympathetic trunk to innervate sympathetic ganglia. the projections of sympathetic preganglionic neurons are segmentally specific. neurons from the 16th cervical (c16) and the first thoracic (t1) spinal cord segments project predominantly in the rostral directi ... | 1998 | 9852585 |
| effects of postprandial hyperlipemia on the vitamin e content of lipoproteins. gerbap section lipoprotéines. groupe d'evaluation et de recherche de l'assistance publique des hôpitaux de paris. | delayed postprandial clearance of triglyceride-rich lipoproteins (tgrl) could induce a decrease of low-density lipoprotein (ldl) and high-density lipoprotein (hdl) vitamin e content through its transfer into tgrl. we thus studied lipoprotein vitamin e content during postprandial hypertriglyceridemia induced by a high fat meal without vitamin e supplement. venous blood was drawn from five healthy male volunteers following a 12 h fast at (t0) then 2 h (t2), 4 h (t4), 6 h (t6) and 8 h (t8) after a ... | 1998 | 9853697 |
| hypoplastic anaemia complicating myxoedema coma. | the case of a 68 year old women presenting in myxoedema coma is described. she was found to be anaemic with a haemoglobin of 8.2 g/dl. further investigations showed a pancytopenia and a hypoplastic anaemia confirmed by bone marrow. the patient recovered and became euthyroid following initial treatment with intravenous tri-iodothyronine (t3) and later oral thyroxine (t4) replacement with resolution of pancytopenia and return of bone marrow to normal. | 1998 | 9854303 |
| radiation therapy and concurrent daily intra-arterial infusion of low-dose cisplatin following alteration of pelvic blood flow for invasive bladder cancer: a preliminary report. | concurrent intra-arterial infusion chemotherapy and radiation therapy following alteration of pelvic blood flow was performed in 15 patients with invasive bladder cancer (t2: 2, t3a: 4, t3b: 5, t4: 4). infusion chemotherapy consisted of a daily low-dose of cisplatin with a dose range of 7 to 9 mg per patient. of the 15 patients, 11 achieved complete response (73%) and other had partial response. four of those with cr developed recurrence (local recurrence in three and distant metastasis in one p ... | 1998 | 9854485 |
| seasonality of meal patterns and hormonal correlates in red deer. | two groups of six adult, castrated, male red deer were housed under natural daylength conditions and at ambient temperature at 57 degrees n and fed ad lib. (al) or at a fixed rate of 50 g/kg0.75 initial liveweight per day throughout the study (restricted, r). mean daily intakes of al animals were higher during periods of long daylength than during short daylength (p < 0.001). the higher rates of food intake during periods of long daylength were a function of greater meal durations (p < 0.001), s ... | 1998 | 9855479 |
| carboxyflavins, novel inhibitors of taq dna polymerase. | carboxyflavins were found to be potent selective inhibitors of taq dna polymerase in a polymerase chain reaction. the inhibitions were dose-dependent, and complete inhibitions were observed at the concentration of 3.0 microm. carboxyflavins were much less, or not sensitive to the dna polymerases tested such as calf thymus dna polymerase alpha, rat dna polymerase beta, human immunodeficiency virus type 1 reverse transcriptase, the klenow fragment of e. coli dna polymerase i and t4 dna polymerase. ... | 1998 | 9855699 |
| additive effect of nitric oxide inhalation on the oxygenation benefit of the prone position in the adult respiratory distress syndrome. | the response to inhaled nitric oxide and prone positioning was investigated in 47 patients with adult respiratory distress syndrome to test the hypothesis that inhalation of nitric oxide when in the prone position would result in additive improvement in oxygenation. | 1998 | 9856714 |
| telomere length, telomerase activity and telomerase rna expression during mouse mammary tumor progression. | to investigate the roles of telomere length (mean length of the terminal restriction fragments; trfs), telomerase activity (ta) and telomerase rna (mtr) expression in relation to mouse mammary tumor progression, we examined a pregnancy-dependent mouse mammary tumor line (tpdmt-4) and its four autonomous sublines (t4-oi320: non-metastatic; and t4-oi165, -oi96, and -oi145: artificial metastatic) of ddd/1 mouse origin, and an autonomous growing mammary tumor (jyg-mc) showing spontaneous lung metast ... | 1998 | 9857231 |
| the tsh-dependent variation of the essential elements iodine, selenium and zinc within human thyroid tissues. | instrumental neutron activation analysis was used in order to measure iodine, selenium and zinc concentration in thyroid samples. a pair of samples of normal and nodular tissue were collected from the thyroid gland from 72 patients selected on the basis of pathological criteria (44 cases of multinodular goiter, 12 of chronic lymphocytic thyroiditis (clt), 6 of thyroid adenoma (ta) and 12 of thyroid cancer (tc)). the check for tissue homogeneity and sampling error was performed by means of the co ... | 1998 | 9857330 |
| [thyroid hormones in old german black pied- and holstein-friesian suckling calves. effects of parturition and postpartum adaptation]. | the present trial deals with the effects of birth stress on the thyreoidea respectively on the thyroxine- and triiodthyronine-concentration as well as on their unbound fraction (ft4 and ft3) of suckler calves and the evolution of those parameters in the first three months of life. t4- and t3 concentrations in blood serum of calves were beyond maternal levels increasing significantly in the first 24 hours with strong individual specificity and reaching levels of adult animals at the end of the th ... | 1998 | 9857410 |
| several new bacteriophage t4 genes, mapped by sequencing deletion endpoints between genes 56 (dctpase) and dda (a dna-dependent atpase-helicase) modulate transcription. | we have analyzed dna of wild-type t4 and of 13 independent large viable deletions isolated by homyk and weil (virology 61 (1974) 505-523) and by little (virology 53 (1973) 47-59), by sequencing, cloning, and expression studies. the deletions can be explained by illegitimate recombination between short (4- to 15-bp) ectopic repeats. in four deletions, adjacent regions are partially homologous, and in at least one of them, the base adjacent to the overlap was deleted during recombination. the sequ ... | 1998 | 9858714 |
| [high dosage thyroxine treatment in therapy and prevention refractory patients with affective psychoses]. | the following review summarizes current knowledge on the treatment of therapy-resistant patients with affective disorders with supraphysiological doses of thyroxine (t4). several groups have reported independently of each other that administration of 200-500 micrograms t4/day has excellent effects in 50-65% of patients a) with bipolar disorder, with or without, "rapid cycling" course, who were previously resistant to all prophylactic drugs and b) in the treatment of therapy-resistant depression. ... | 1998 | 9859125 |
| variations in posteroanterior stiffness in the thoracolumbar spine: preliminary observations and proposed mechanisms. | evaluation of posteroanterior (pa) movement in the spine is commonly used in the clinic, but little is known about the mechanisms involved. the purposes of this study were to examine variations in pa stiffness along the thoracolumbar spine and to investigate possible factors that might determine the pattern of stiffness. | 1998 | 9859947 |
| stimulation of bacteriophage t4 middle transcription by the t4 proteins mota and asia occurs at two distinct steps in the transcription cycle. | the bacteriophage t4 encodes proteins that are responsible for tightly regulating mrna synthesis throughout phage development in escherichia coli. the three classes of t4 promoters (early, middle, and late) are utilized sequentially by the host rna polymerase as a result of phage-induced modifications. one such modification is the tight binding of the t4 asia protein to the sigma70 subunit of the rna polymerase. this interaction is pivotal for the transition between t4 early and middle transcrip ... | 1998 | 9860954 |
| mivacurium compared with succinylcholine in children with liver disease. | we have compared mivacurium and succinylcholine in 27 paediatric patients with mild (child's a) to moderate (child's b) liver disease undergoing oesophagogastroduodenoscopy (ogd) and injection of oesophageal varices, with 10 healthy children receiving mivacurium for ent procedures. with mivacurium 0.2 mg kg-1, the severity of liver disease did not correlate with duration of block compared with controls (time from bolus to t1 25%, p = 0.74; t1 25% to t4:t1 > 0.7, p = 0.545). however, initial reco ... | 1998 | 9861140 |
| effects of thyroidectomy and thyroxine replacement on seasonal reproduction in the red deer hind. | two experiments were conducted to test whether thyroid hormones are required for the cessation of the breeding season in female red deer. in expt 1, 16 mature hinds were allocated early in the breeding season (may) to the following groups: thyroidectomized (thx), thyroidectomized and treated with subcutaneous thyroxine implants which increased plasma tri-iodothyronine to physiological concentrations (thx + t4), or euthyroid controls. plasma progesterone concentrations consistent with oestrous cy ... | 1998 | 9861164 |
| gestational transient hyperthyroxinaemia (gth): screening for thyroid function in 23,163 pregnant women using dried blood spots. | transient elevation of serum free t4 (gestational transient hyperthyroxinaemia; gth) occurs occasionally during normal pregnancy, especially in early gestation. however, the frequency of gth and its clinical features remain unclear to date. the aim of this study was to determine the occurrence rate of gth and the relation between serum levels of hcg, free t4 (ft4), and tsh in a large number of pregnant women. | 1998 | 9861323 |
| laryngeal cancer in lower silesia: descriptive analysis of 501 cases. | this paper presents a descriptive analysis of 501 cases of laryngeal cancer. the patients were classified according to their age, sex, primary tumour localisation and stage. there were 448 males and 53 females, with a male-to-female ratio of 8.5:1. the peak incidence of cancer was detected in the 6th and 7th decades of age. the most common primary tumour localisation was the glottis. three-hundred-and-forty patients presented at advanced tumour stages (t3/t4). the proportion of patients presenti ... | 1998 | 9861343 |
| pharmacological effects of propylthiouracil on corticosterone secretion in male rats. | we investigated the direct effects of propylthiouracil (ptu) on corticosterone secretion both in vivo and in vitro. | 1998 | 9861780 |
| acute effects of chundosunbup qi-training on blood concentrations of tsh, calcitonin, pth and thyroid hormones in elderly subjects. | the present study investigated how the systemic treatment of a programmed exercise, chundosunbup (cdsb) qi-training, affects the secretion of thyroid and parathyroid hormones in elderly subjects (10 male and 5 female). plasma concentrations of thyroid stimulating hormone (tsh), triiodothyronine (t3), thyroxine (t4), parathyroid hormone (pth), ionized calcium, and calcitonin were determined. cdsb qi-training induces a slight increase in tsh. both t4 and t3 were increased at the mid-time of cdsb q ... | 1998 | 9862015 |
| staging of breast cancer: what standards should be used in research and clinical practice? | bone scan (bs), chest x-rays (cxr), liver ultrasonography (lus) and laboratory parameters (lp) are frequently used as routine staging procedures for breast cancer patients. these procedures are not always appropriate in either clinical or research settings, regardless of the stage. the aim of this study was to identify groups of patients with differing risks for metastases in order to select more precise standard staging procedures. | 1998 | 9862046 |
| gfp:hiv-1 protease production and packaging with a t4 phage expression-packaging processing system. | a bacteriophage t4-derived protein expression, packaging and processing system was used to create recombinant phage that encode, produce and package a protein composed of human hiv-1 protease fused to green fluorescent protein (gfp). the fusion protein is targeted within the phage capsid by an n-terminal capsid targeting sequence (cts), which is cleaved through proteolysis by the viral scaffold protease p21. the fusion protein is designated cts [symbol see text] gfp:pr. the [symbol see text] sym ... | 1998 | 9863054 |
| [therapeutic effect and its mechanism exploration on mainly using traditional chinese medicine of replenishing qi and nourishing yin in treating graves disease]. | to explore the therapeutic effect and its mechanism mainly using traditional chinese medicine (tcm) of replenishing qi and nourishing yin (rqny) with a small dosage of tapazol for treatment of graves disease (gd). | 1997 | 9863122 |
| [hypotension in acyclovir therapy]. | a 51 year old man developed herpes zoster on the right arm (c5/c6) treated subsequently with aciclovir infusions (500 mg, 3/day). ten months before hospital admission he did have a radical resection of a epi-oro-hypopharyngeal carcinoma (t4/n1/g2, m0; lymphangiosis carcinomatosa) as well as a partial laryngeal resection for a recurrence 3 months later and removal of a cervical lymph node metastasis after two further months. during aciclovir treatment the patient experienced repeated bradycardia ... | 1998 | 9865134 |
| [current results of the treatment of cervical metastatic lymph nodes by concurrent hyperfractionation of carboplatin and irradiation]. | the results of the treatment of metastatic neck nodes is evaluated after a mean follow-up of 24 months (maximum 45 months). fifty-seven patients with epidermoid carcinoma of the head and neck were treated according to a hyperfractionated chemoradiation schedule including two fractions a day. each fraction consisted of 10 mg carboplatin + 115 cgy. two fractions were given each day, five days a week, for a total dose of 700 mg carboplatin + 8050 cgy. whenever possible, surgical salvage was perform ... | 1998 | 9866222 |
| utility of third generation thyrotropin assays in thyroid function testing. | determination of thyrotropin (tsh) by sensitive immunometric assays is currently judged as the most sensitive and also most cost-effective first-line approach to thyroid function testing. further improvement of assay sensitivity has led to the description of third generation tsh assays with a functional sensitivity in the range of 0.01 to 0.02 mu/l. in the present study, we analyzed interassay precision profiles of a commercially available third generation assay (acs:180 tsh-3) and documented th ... | 1998 | 9867193 |
| compensatory changes in groel/gp31 affinity as a mechanism for allele-specific genetic interaction. | previous work has shown that the groel-groes interaction is primarily mediated by the groes mobile loop. in bacteriophage t4 infection, groes is substituted by the gene 31-encoded cochaperonin, gp31. using a genetic selection scheme, we have identified a new set of mutations in gene 31 that affect interaction with groel; all mutations result in changes in the mobile loop of gp31. biochemical analyses reveal that the mobile loop mutations alter the affinity between gp31 and groel, most likely by ... | 1999 | 9867810 |
| [value and limits of surgery in stage iiib non-small-cell bronchial cancers]. | according to the tnm staging system for lung cancers, stage iii is divided into iiia and iiib. this division was based upon the principle that patients with iiia disease could theoretically benefit from complete resection, contrasting with iiib patients for whom surgery is not feasible. the poor prognosis of stage iiib is largely due to its classical inoperability. from the surgical point of view, stage iiib can be subdivided into four subgroups: 1) n3 where resection is possible in selected pat ... | 1998 | 9868402 |
| randomized clinical trial on the combination of preoperative irradiation and surgery in the treatment of adenocarcinoma of gastric cardia (agc)--report on 370 patients. | an attempt was made to define the role of radiotherapy before operation for agc. | 1998 | 9869212 |
| prognostic implications of downstaging following preoperative radiation therapy for operable t3-t4 rectal cancer. | to evaluate the prognostic value of tumor downstaging after preoperative radiation for resectable rectal cancer. | 1998 | 9869213 |
| carcinoma of the tonsillar fossa: prognostic factors and long-term therapy outcome. | to identify prognostic parameters and evaluate the therapeutic outcomes for patients with carcinoma of the tonsillar fossa treated with three treatment modalities. | 1998 | 9869232 |