Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| surgery versus surgery and postoperative radiotherapy in squamous cell carcinoma of the buccal mucosa: a comparative study. | the efficacy of postoperative radiotherapy for squamous cell carcinoma of the buccal mucosa was evaluated. | 1998 | 9754758 |
| effect of increasing running velocity on electroencephalogram in a field test. | this study was designed to measure the electroencephalogram (eeg) after exercise with increasing intensity. in a field test with increments in running velocity a 2-min eeg was recorded, together with blood lactate concentration and heart rate, after each stage. an individual protocol was used, with up to six stages of running to ensure comparability of exercise intensity among the subjects, in each of 19 athletes (17 men, 2 women) experienced in leisure-time running. the exercise consisted initi ... | 1998 | 9754974 |
| effect of interleukin-8 on production of tumor-associated substances and autocrine growth of human liver and pancreatic cancer cells. | we have previously reported that human liver cancer cell lines produce interleukin-8 (il-8) at high levels. those tumor cells appeared to express two kinds of il-8 receptor on their surface. in order to analyze the role of il-8 on the biological characteristics of those tumor cells, we suppressed il-8 production from human liver (huh-7 and hucc-t1) and pancreatic cancer cell lines (hup-t4) by treatment with il-8 antisense oligonucleotides. suppression of il-8 production resulted not only in inhi ... | 1998 | 9755878 |
| substrate oxidation and thyroid hormone response to the introduction of a high fat diet in formerly obese women. | to investigate the adaptation in substrate utilization to a sudden change in dietary composition from a medium fat to a high fat diet, during a three day period in formerly obese and never obese women. | 1998 | 9756245 |
| structure of bacteriophage t4 fibritin m: a troublesome packing arrangement. | fibritin, a 52 kda product of bacteriophage t4 gene wac, forms 530 a long fibers, named whiskers, that attach to the phage neck and perform a helper function during phage assembly. fibritin is a homotrimer, with its predominant central domain consisting of 12 consecutive alpha-helical coiled-coil segments linked together by loops. the central domain is flanked by small globular domains at both ends. fibritin m is a genetically engineered fragment of the wild type and contains 74 amino-acid resid ... | 1998 | 9757094 |
| [isolated intramedullary cysticercosis. case report]. | cysticercosis is the most common parasitic disease affecting the central nervous system. although it is still very rare in europe, the frequency will increase due to the influx of immigrants from the endemic areas and increasing trips in these countries. spinal intramedullary cysticercosis is an uncommon manifestation of neurocysticercosis. | 1998 | 9757347 |
| iodide induces thyroid autoimmunity in patients with endemic goitre: a randomised, double-blind, placebo-controlled trial. | iodine is essential for normal thyroid function and the majority of individuals tolerate a wide range of dietary levels. however, a subset of individuals, on exposure to iodine, develop thyroid dysfunction. in this double-blind trial, we evaluated the efficacy and tolerability of low-dose iodine compared with those of levo-thyroxine (t4) in patients with endemic goitre. | 1998 | 9758438 |
| in vitro inhibition of thyroid hormone sulfation by hydroxylated metabolites of halogenated aromatic hydrocarbons. | earlier studies in our laboratory showed that hydroxylated metabolites of polychlorinated biphenyls (pcbs), dibenzo-p-dioxins (pcdds), and dibenzofurans (pcdfs) competitively inhibit thyroxine (t4) binding to transthyretin (ttr) and type i deiodinase (d1) activity. in this study, we investigated the possible inhibitory effects of hydroxylated metabolites of polyhalogenated aromatic hydrocarbons (phahs) on iodothyronine sulfotransferase activity. rat liver cytosol was used as a source of sulfotra ... | 1998 | 9760282 |
| comparison of the effects of iodine and iodide on thyroid function in humans. | concerns have been raised over the use of iodine for disinfecting drinking water on extended space flights. most fears revolve around effects of iodide on thyroid function. iodine (i2) is the form used in drinking-water disinfection. risk assessments have treated the various forms of iodine as if they were toxicologically equivalent. recent experiments conducted in rats found that administration of iodine as i- (iodide) versus i2 had opposite effects on plasma thyroid hormone levels. i2-treated ... | 1998 | 9761130 |
| diverse effects of mild and potent goitrogens on blood-brain barrier nutrient transport. | populations living in goitre endemic areas consume foods rich in a variety of goitrogens of different potencies and some are severely hypothyroid. recently we observed in wistar/nin rats that chronic feeding of kscn to dams produced only a moderate hypothyroidism and decreased the transport of 2-deoxy-d-glucose (2-dg) across the blood-brain barrier (bbb) in the offspring. the present studies were conducted to assess whether severe hypothyroidism would have greater effect on bbb nutrient transpor ... | 1998 | 9761461 |
| time-course analysis of cd25 and hla-dr expression on lymphocytes in interferon-beta 1b-treated multiple sclerosis patients. | to identify immunological markers that could be used to monitor relapsing-remitting multiple sclerosis (rrms) course/activity during interferon beta 1b (ifn beta 1b) therapy, we longitudinally studied hla-dr and cd25 expression by t lymphocytes in 15 ifn beta 1b-treated rrms patients. peripheral blood t cell subsets were analysed before therapy (t0), and after 1 (t1), 2 (t2), 3 (t3), 6 (t4) and 12 (t5) months after therapy initiation. hla-dr expression and the cd3+hla-dr+ t cell number showed a ... | 1998 | 9762669 |
| regional sympathetic function in high spinal cord injury during mental stress and autonomic dysreflexia. | centrally mediated sympathetic stimulation of subjects who have suffered a spinal cord injury (sci) does not activate the decentralized part of the body below the level of the lesion, whereas experimental data indicate an exaggerated response above the level of the lesion. sci subjects may exhibit an autonomic dysreflexia reaction following afferent stimulation below the level of the lesion. in order to investigate the function of the sympathetic nervous system above and below the level of the l ... | 1998 | 9762959 |
| prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. | to review a large single-center experience of patients treated for upper tract transitional cell carcinoma (tcc) with extended follow-up in order to identify patterns of recurrence, assess patient outcomes, and determine the impact of traditional prognostic factors. | 1998 | 9763077 |
| [hyperthyroidism induced by iodinated roentgen contrast media]. | three patients with subclinical hyperthyroid goitre, women aged 63, 72 and 75 years following intravenous administration of an iodinated contrast medium developed hyperthyroidism with a marked rise of the concentration of free t4. thyreostatic agents were unsuccessful in two patients, the third was left untreated. hyperthyroidism improved spontaneously in all three. iodine-induced hyperthyroidism is rare and is usually encountered in patients with a pre-existent autonomous thyroid function. trea ... | 1998 | 9763853 |
| perioperative cytokine release during coronary artery bypass grafting in patients of different ages. | surgical interventions and cardiopulmonary bypass (cpb) induce a systemic inflammatory response with cytokine release. ageing is perceived as a process of impaired immune functions: il-1beta, il-6 and tumour necrosis factor-alpha (tnf-alpha) secretion are increased while il-2 release is reduced in advanced age. at present, little information is available about perioperative immune reactions at different stages of ageing. the aim of the present study was to compare il-6, il-1beta, tnf-alpha, il-1 ... | 1998 | 9764599 |
| cloning and expression of a novel, tissue specifically expressed member of the udp-galnac:polypeptide n-acetylgalactosaminyltransferase family. | we report the cloning and expression of the fifth member of the mammalian udp-galnac:polypeptide n-acetylgalactosaminyltransferase (ppgantase) family. degenerate polymerase chain reaction amplification and hybridization screening of a rat sublingual gland (rslg) cdna library were used to identify a novel isoform termed ppgantase-t5. conceptual translation of the cdna reveals a uniquely long stem region not observed for other members of this enzyme family. recombinant proteins expressed transient ... | 1998 | 9765313 |
| changes in thyroid hormone levels during growth hormone therapy in initially euthyroid patients: lack of need for thyroxine supplementation. | the occurrence of central hypothyroidism in previously euthyroid children during gh therapy has been reported with widely varying incidence. we monitored the acute effects on the hypothalamic-pituitary-thyroid axis in 15 euthyroid children with classic gh deficiency during the first year of gh therapy. all were initially euthyroid, as assessed by normal baseline tsh, t4, free t4, and t3 levels and negative antithyroid antibodies. a thyroid profile (t4, free t4 index, t3, rt3, and tsh) was perfor ... | 1998 | 9768652 |
| circulating iodide concentrations during and after pregnancy. | early, indirect studies suggested that an important aspect of thyroid economy during pregnancy was a decline in plasma or serum inorganic iodide (pii) concentrations, but there is little information concerning circulating iodide concentrations as assessed by direct measurement. the present study was undertaken to determine the relationship between gestation and serum iodide concentrations as assessed by direct measurement of pii. pii concentrations, urinary iodide levels, and other parameters of ... | 1998 | 9768662 |
| complete thyroxine-binding globulin (tbg) deficiency produced by a mutation in acceptor splice site causing frameshift and early termination of translation (tbg-kankakee). | fourteen t4-binding globulin (tbg) variants have been identified at the gene level. they are all located in the coding region of the gene and 6 produce complete deficiency of tbg (tbg-cd). we now describe the first mutation in a noncoding region producing tbg-cd. the proband was treated for over 20 yr with l-t4 because of fatigue associated with a low concentration of serum total t4. fifteen family members were studied showing low total t4 inherited as an x chromosome-linked trait, and affected ... | 1998 | 9768672 |
| low growth hormone-binding protein in infants with congenital hypothyroidism. | we evaluated the circulating levels of gh, insulin-like growth factor i (igf-i), gh-binding protein (ghbp), and igf-binding protein-3 (igfbp-3) before l-t4 therapy in 19 infants with congenital hypothyroidism (ch), aged 12-29 days, diagnosed by neonatal screening and in a group of age- and sex-matched control infants. the same parameters were reevaluated after several months of treatment. serum ghbp was measured by the high performance liquid chromatography-gel filtration method; serum gh, igf-i ... | 1998 | 9768678 |
| the advantages of the lateral decubitus position after spinal anesthesia with hyperbaric tetracaine. | we investigated the effects of lateral decubitus positioning after spinal anesthesia with hyperbaric tetracaine on the spread of sensory blockade and hemodynamic variables. one hundred asa physical status i or ii patients scheduled for elective surgery to the lower limb received spinal anesthesia at a rate of approximately 0.1 ml/s using 0.5% tetracaine in 7.5% glucose with 0.125% phenylephrine in the lateral decubitus position with the operated side dependent. they were randomly divided into th ... | 1998 | 9768787 |
| concentrations of vascular endothelial growth factor in the sera of gastric cancer patients. | vegf (vascular endothelial growth factor) is known to play crucial roles in tumor angiogenesis. in 281 gastric cancer patients, aberrant increase of vegf level was observed in 36 patients (12.8%). in 14 recurrent patients, 8 showed an increase of vegf. the serum vegf levels of stage iv cancer were significantly higher than those of stage i. the serum levels of recurrent patients were significantly higher than those of stage i, ii and iii. vegf levels of patients with serosal invasion were signif ... | 1998 | 9769380 |
| [cellular and humoral immunity in atopic dermatitis]. | in vitro tests of cellular and humoral immunity were analysed by: t and b lymphocytes, t4 and t8 lymphocyte subsets, lymphocyte blast transformation tests with unspecified mitogenom--phytohemaglutinin, c3 and c4 components of the complement and circulating immune complexes at patients from 6 to 54 years old who suffered from atopic dermatitis without any other clinical symptom of atopy (so called "pure" atopic dermatitis). parameters of cellular and humoral immunity were analysed in the active a ... | 1998 | 9769640 |
| efficacy of dose-intensified mec (methotrexate, epirubicin and cisplatin) chemotherapy for advanced urothelial carcinoma: a prospective randomized trial comparing mec and m-vac (methotrexate, vinblastine, doxorubicin and cisplatin). japanese urothelial cancer research group. | to evaluate the antitumor activity in patients with t3b, t4 or metastatic urothelial carcinoma treated with mec or m-vac chemotherapy, by performing a multi-center randomized prospective study. | 1998 | 9769784 |
| characterisation of the bacteriophage t4 comc alpha 55.6 and comcj mutants. a possible role in an antitermination process. | we have performed a new screen for t4 mutants (comc) that overcome the phage growth restriction caused by the escherichia coli rho/tabc mutants. we show that one such mutant (comcj) identifies a different gene from that identified by canonical comc mutants. we compare the regulation of t4 prereplicative transcription in a rho/tabc mutant infected by t4 wild-type, by a canonical comc mutant (comc alpha 55.6) and by comcj. the transcription rates of the two prereplicative genes 39 and 43 is depres ... | 1998 | 9770273 |
| deficient dna-ligase activity in the metabolic disease tyrosinemia type i. | hereditary tyrosinemia type i (ht1) is an autosomal recessive inborn error of metabolism caused by the deficiency of fumarylacetoacetate hydrolase, the last enzyme in the tyrosine catabolism pathway. this defect results in accumulation of succinylacetone (sa) that reacts with amino acids and proteins to form stable adducts via schiff base formation, lysine being the most reactive amino acid. ht1 patients surviving beyond infancy are at considerable risk for the development of hepatocellular carc ... | 1998 | 9770534 |
| the influence of intrathecal fentanyl on the characteristics of subarachnoid block for caesarean section. | forty healthy parturients scheduled for elective caesarean section were randomly allocated to receive either 0.3 ml 0.9% saline (control group, n = 20), or 15 micrograms (0.3 ml) fentanyl (treatment group, n = 20) added to 2.5 ml 0.5% hyperbaric bupivacaine given intrathecally in the sitting position. a sensory block to t4 was achieved after 6.5 min in those who received fentanyl compared to 8.0 min in the control group; this was not significantly different. the highest level of sensory block ac ... | 1998 | 9771182 |
| [effect of osthol and total coumarins of fructus cnidii on thyroid hormone and thyrotropic hormone in kidney-yang deficiency rats]. | osthol and total coumarins of fructus cnidii were given to the model of kidney-yang deficiency rats induced by hydrocortison acetate injection, the changes of serum concentration of thyroxine t3, reverse t3 (rt3), t4 and thyroid stimulating hormone (tsh) were observed. results showed that in comparison with normal rats, all of the criteria mentioned above were lowered significantly (p < 0.01) in model rats. after treatment, the criteria observed were all increased significantly (p < 0.01 or p < ... | 1996 | 9772606 |
| [hypothyroidism--clinical findings, diagnosis, therapy. thyroid tests should be performed on broad indications]. | hypothyroidism is a clinical entity resulting from deficiency of thyroid hormones or, more rarely, from their impaired activity at tissue level. it is a common condition, with a prevalence of 1.9 per cent in women, and the prevalence increases with age. hypothyroidism may be congenital or acquired, primary or secondary, chronic or transient. primary hypothyroidism is caused by disease or treatment which destroys the thyroid gland or interferes with thyroid hormone biosynthesis. autoimmune thyroi ... | 1998 | 9772803 |
| vasopressor hormone response following mesenteric traction during major abdominal surgery. | we investigated the vasopressor hormone response following mesenteric traction (mt) with hypotension due to prostacyclin (pgi2) release in patients undergoing abdominal surgery with a combined general and epidural anesthesia. | 1998 | 9773140 |
| inhibition and activation of the thyroidal axis by the adrenal axis in vertebrates. | hormones of the adrenal or interrenal axis and stress situations which induce elevated glucocorticoid plasma levels (e.g. handling and starvation), inhibit thyroid function in growing and adult vertebrates. however, data indicate that during foetal and embryonic development (mammals and birds) or during larval growth and metamorphosis (fish and amphibians), the adrenal axis may stimulate thyroid function. recent findings have provided some information concerning this stimulatory interference of ... | 1998 | 9773500 |
| impaired thyroid function in murine toxoplasmosis. | a decline in serum thyroxine (t4) occurs in nya: nylar female mice infected with toxoplasma gondii. to ascertain whether the hypothyroxinaemia might be the result of primary thyroid dysfunction, 2 parameters of thyrofollicular cell function were monitored to determine (a) if the cell surface membrane receptors for thyroid-stimulating hormone (tsh) were operative, and (b) whether the cyclic adenosine monophosphate (camp)-dependent cascade of intracellular events leading to the release of t4 was r ... | 1998 | 9774785 |
| aetiology of thyroidal dysfunction in murine toxoplasmosis. | mice infected with toxoplasma gondii manifest a rapid decline in serum thyroxine (t4) levels. to locate the locus of the hypothyroxinaemia, the integrity of the pituitary-thyroid axis of infected mice was assessed by a thyrotropin-releasing hormone (trh) assay. a rise in serum t4 after inoculation of trh implies the release of thyrotropin (thyroid-stimulating hormone) from a functionally intact pituitary. administration of a single, large-dose (1 microgram) bolus of trh to infected mice induced ... | 1998 | 9774786 |
| [papillary carcinoma of the thyroid. a uni- and multivariate analysis of the factors affecting the prognosis inclusive of surgical treatment]. | a total of 463, out of 677 patients operated on for papillary thyroid carcinoma between 1967-1995, were selected, on the basis of a 5-year minimal follow-up (max 28, mean 11.15 +/- 5.29), for uni and multivariate analysis of survival curves. patient sex, age over and under 45 years, tumour size smaller and larger than 15 mm, stage, any tnm parameter, histological variety, surgical procedure on the thyroid and nodes were the factors assessed in order to express the prognosis. | 1998 | 9774838 |
| [hyperthyroidism in people over 50 years of age in senegal. study of 31 cases observed over a 14-year period]. | though common in elderly, with poor and masked symptomatology, hyperthyroidism has never been studied in people older than 50 years of age in african countries. | 1998 | 9775148 |
| aesthesioneuroblastoma. | forty patients were treated or followed up for aesthesioneuroblastoma between 1980 and 1995 at institut gustave roussy, france. there were three t1, seven t2, 15 t3 and 15 t4 lesions. the cervical metastatic rate at presentation was 18 per cent. distant metastases were detected by bone marrow biopsy and bone scan in three patients at presentation. treatment modalities included surgery alone in eight patients, radiotherapy alone in three patients, combined modality surgery plus radiotherapy in 11 ... | 1998 | 9775291 |
| guanine is the target for direct ionisation damage in dna, as detected using excision enzymes. | exposure of an aqueous, aerated solution (ph 7) of a double-stranded dna to 193 nm light, of sufficient energy to ionise dna, leads to selective, non-random modification at guanine in the form of frank single-strand break (ssb) and base modifications, revealed by treatment with either escherichia coli formamidopyrimidine-dna glycosylase (fpg), escherichia coli endonuclease iii (nth) or hot piperidine treatment. there is a similar neighbouring base sequence dependence for fpg- and nth-sensitive d ... | 1998 | 9776756 |
| circular dichroism and uv melting studies on formation of an intramolecular triplex containing parallel t*a:t and g*g:c triplets: netropsin complexation with the triplex. | we have used circular dichroism and uv absorption spectroscopy to characterize the formation and melting behaviour of an intramolecular dna triple helix containing parallel t*a:t and g*g:c triplets. our approach to induce and to stabilize a parallel triplex involves the oligonucleotide 5'-d(g4a4g4[t4]c4t4c4-[t4]g4t4g4) ([t4] represents a stretch of four thymine residues). in a 10 mm sodium cacodylate, 0.2 mm disodium edta (ph 7) buffer, we have shown the following significant results. (i) while ... | 1998 | 9776765 |
| [effect of thyroid hormones on the modulation of genetic expression of liver cytosolic malic enzyme, in rats poisoned with hexachlorobenzene]. | hexachlorobenzene (hcb) is a widespread environmental pollutant. chronic exposure of laboratory animals to hcb triggers porphyria, induction of liver microsomal enzymes, low levels of t4 reproductive dysfunction's, liver and thyroid tumors. previous findings from our laboratory have shown that hcb increased the activity of the liver thyroid-responsive enzymes: malic enzyme (me), glucose-6-phosphate dehydrogenase (g6pd) without any change in the mytochondrial alpha-glycerophosphate dehydrogenase ... | 1998 | 9777035 |
| the effect of recombinant human thyrotropin (rhtsh) on thyroid function in mice and rats. | the vast majority of studies to determine the biological activity of recombinant human thyrotropin (rhtsh) have been carried out in the mouse. we have recently reported that 0.1 mg of rhtsh im (one-ninth the dose given in thyroid cancer patients) given to normal subjects elicits a brisk rise in serum thyroxine (t4), triiodothyronine (t3), and thyroglobulin (tg) concentrations. in contrast, in initial studies in the rat, a low dose of rhtsh failed to increase serum t4 or t3 concentrations. the pr ... | 1998 | 9777753 |
| kinetic characterization of a bacteriophage t4 antimutator dna polymerase. | fidelity of dna replication by bacteriophage t4 dna polymerase is achieved in a multiplicative process: base selection by its polymerase activity and removal of misincorporated nucleotides by its exonuclease activity. the wild-type polymerase is capable of maintaining a balance between the two activities so that dna replication fidelity is maximized without excessive waste of nucleotides. antimutator enzymes exhibit a higher dna replication fidelity than the wild-type enzyme, at the cost of incr ... | 1998 | 9778349 |
| overexpression of transforming growth factor-beta1 in scirrhous carcinoma of the stomach correlates with decreased survival. | a retrospective study of 50 patients with scirrhous carcinoma of the stomach who had undergone surgery was performed to elucidate whether immunohistochemical overexpression of transforming growth factor-beta1 (tgf-beta1) could predict the patients' survival. to evaluate the proliferative activity of the tumor, the proliferating cell nuclear antigen (pcna) index was used. expression of tgf-beta1 was low in 27 patients and high in 23. clinicopathological characteristics were not significantly diff ... | 1998 | 9778627 |
| [the demonstration of blood flow in focal breast lesions by power-doppler sonography. a new approach to assessment?]. | power-doppler sonography is regarded as a very sensitive method for detecting low-velocity and low-volume blood flows. the purpose of our study was to investigate whether increased vascularity in breast carcinoma can be visualized by power-doppler sonography and whether new criteria for differentiating benign and malign lesions can be found. | 1998 | 9779062 |
| bone mineral density by single photon x-ray absorptiometry in chilean children and adolescents. | to assess bone mineralization in healthy chilean children and adolescents, considering sex, age, height, and puberty. | 1998 | 9779858 |
| cerebellar microfolia and other abnormalities of neuronal growth, migration, and lamination in the pit1dw-j homozygote mutant mouse. | the snell dwarf mouse (pit1dw-j homozygote) has a mutation in the pit1 gene that prevents the normal formation of the anterior pituitary. in neonates and adults there is almost complete absence of growth hormone (gh), prolactin (prl), thyroxin (t4), and thyroid-stimulating hormone (tsh). since these hormones have been suggested to play a role in normal development of the central nervous system (cns), we have investigated the effects of the pit1dw-j mutation on the cerebellum and hippocampal form ... | 1998 | 9779941 |
| translation efficiencies of the 5' untranslated region from representatives of the six major genotypes of hepatitis c virus using a novel bicistronic reporter assay system. | the 5' untranslated region (5'utr) of hepatitis c virus (hcv) contains an internal ribosome entry site (ires) which directs translation of the viral open reading frame (orf). the 5'utr is highly conserved between virus isolates in both primary sequence and predicted secondary structure. we cloned and sequenced the 5' regions (nt 18 of the 5'utr to nt 15 of the core coding sequence) of hcv isolates representing the six major genotypes and subcloned these into a bicistronic, dual luciferase report ... | 1998 | 9780040 |
| effects of photoperiod and age on secretory patterns of luteinizing hormone and testosterone and semen production in male domestic turkeys. | the objective of this study was to determine effects of photoperiod and age on the circulating concentrations of lh, testosterone (t), thyroxine (t4), and semen production in male turkeys. male turkeys from 10 or 12 wk of age were maintained under either a long-day (ld) photoperiod of 16l:8d up to 35 wk (ll), or a short-day (sd) photoperiod of 6l:18d to 29 wk and then an ld photoperiod of 16l:8d up to 35 wk of age (sl). plasma concentrations of both lh and t increased by 17 or 18 wk of age under ... | 1998 | 9780324 |
| [locoregional treatment of breast cancer: surgery and radiotherapy]. | locoregional control of breast cancer can be achieved with surgery and radiotherapy. surgery and irradiation is advocated for in situ carcinoma and invasive breast cancer. for t4 lesions, breast cancer locoregional treatment must be performed after neoadjuvant therapy. locoregional recurrences without distant metastasis need radical surgery with or without neoadjuvant chemotherapy. locoregional control of breast cancer is a part of the multidisciplinary approach of this disease. | 1998 | 9781210 |
| acute and delayed effects of a single-dose injection of interleukin-6 on thyroid function in healthy humans. | interleukin-6 (il-6) is produced in response to inflammatory and noninflammatory stress and acts as the principal regulator of the acute-phase protein response. il-6 stimulates the hypothalamic-pituitary-adrenal axis and may be involved in the thyroid function abnormalities observed in nonthyroidal illness (nti). this study examined the effects of single-dose il-6 (3 microg/kg subcutaneously [s.c.]) in healthy human subjects: 19 received il-6 and 13 received control saline injection. the dose of ... | 1998 | 9781636 |
| dna recognition by structure-selective nucleases. | the nucleases discussed in this review show little sequence specificity but instead recognize certain structural features of their respective dna substrates. the level of their structural selectivity ranges from simple discrimination between single- and double-stranded dna (nucleases p1 and s1), the recognition of helical parameters like groove width and flexibility (dnase i), the recognition of helical distortions caused by abasic sites (exonuclease iii, hap1), to the recognition of specialized ... | 1997 | 9782777 |
| endotoxins and endocrine system. | there is good evidence for the interaction of neuroendocrine and immune systems. endotoxin (lps)-induced mediators (e.g., cytokines, prostaglandins etc) set on endocrine organs (e.g., the hypothalamo-pituitry-adrenal axis; thyroid glands etc). endotoxin-treated, intestinal ischemic, or irradiated rats show decreased t4 levels of blood. these animals cannot respond to tsh because the tsh-receptors of follicular membranes are disturbed by lps in the thyroid glands. radiodetoxified endotoxin is an ... | 1998 | 9785034 |
| [influence on patients with sjögren's syndrome after the great hanshin-awaji earthquake]. | we investigated the influence of clinical findings on patients with sjögren's syndrome after the great hanshin-awaji earthquake. fifty eight (90%) of 64 patients were struck severely by the earthquake and 26 patients (42%) were forced to take refuge in emergency shelters. there was no aggravation of clinical findings or complications in eight patients inhabiting the area where the damage was mild. dry eyes were deteriorated in 14 patients (22%). dry mouth was aggravated in 6 patients (9%). howev ... | 1998 | 9785986 |
| [an influence of preop chemotherapy on the hormonal status of the patient with stomach cancer]. | in a gastric cancer patients it was established while examining the concentration of triiodothyronine (t3), thyroxin (t4), prolactin, hydrocortisone and insulin in a blood serum, that the chemotherapy conduction simultaneously with intensive preoperative schedule do not cause the hormone control disorders. it causes an absence of increase of postoperative complications occurrence and lethality as well. | 1998 | 9787563 |
| preoperative radiation with concurrent 5-fluorouracil continuous infusion for locally advanced unresectable rectal cancer. | to determine the percentage of complete responders and the resectability rate for patients with locally advanced carcinoma of the rectum treated by 5-fluorouracil (5-fu) infusional chemotherapy and pelvic radiation. | 1998 | 9788410 |
| irradiation in carcinoma of the vulva: factors affecting outcome. | this report reviews the increasing role of radiation therapy in the management of patients with histologically confirmed vulvar carcinoma, based on a retrospective analysis of 68 patients with primary disease (2 in situ and 66 invasive) and 18 patients with recurrent tumor treated with irradiation alone or combined with surgery. | 1998 | 9788413 |
| extending the indications for breast-conserving treatment to patients with locally advanced breast cancer. | breast-conserving therapy (bcs) has generally been limited to t1 and t2 lesions because it has been thought impossible to achieve good local control with satisfactory cosmesis in patients with more advanced disease. however, many patients with t3 and t4 lesions will exhibit dramatic tumor downstaging with neoadjuvant chemotherapy. it is our hypothesis that for these patients bcs can be performed with good local control and cosmesis. | 1998 | 9788414 |
| a viral suppressor of gene silencing in plants. | gene silencing is an important but little understood regulatory mechanism in plants. here we report that a viral sequence, initially identified as a mediator of synergistic viral disease, acts to suppress the establishment of both transgene-induced and virus-induced posttranscriptional gene silencing. the viral suppressor of silencing comprises the 5'-proximal region of the tobacco etch potyviral genomic rna encoding p1, helper component-proteinase (hc-pro) and a small part of p3, and is termed ... | 1998 | 9789044 |
| [evolution of diagnostic and therapeutic criteria in graves' disease in spain. comparison of the results of 2 surveys in 1987 and 1995]. | to assess the new diagnostic and therapeutic trends for hyperthyroidism due to graves' disease in spain and the differences with respect to a previous study performed in 1987. | 1998 | 9789225 |
| sexuality during pregnancy and the year postpartum. | there have been a few studies conducted on couples' sexual behavior during pregnancy and the year postpartum, but those studies contain sampling bias resulting from recruiting volunteers for sex research. the sample for the current research was recruited for a far less sensitive study, and includes data from both mothers and fathers. | 1998 | 9789517 |
| the effect of exercise training intensity on thyroid activity at rest. | the influence of exercise training intensity on thyroid activity at rest was studied in male wistar rats, weighting 114 g +/- 24 (mean +/- sd) at the beginning of the experiment. animals were assigned to the following groups: untrained controls and rats trained on a treadmill at the speed of 20 m/min over a 5-week period with different intensities: 2 x 60 min weekly, 4 x 60 min, 6 x 20 min, 6 x 40 min and 6 x 60 min weekly. thyroid peroxidase (tpo) and hepatic iodothyronine 5'-monodeiodinase (5' ... | 1998 | 9789797 |
| missense mutation (c1263r) in the thyroglobulin gene causes congenital goiter with mild hypothyroidism by impaired intracellular transport. | metabolic abnormalities in thyroid hormonogenesis cause congenital goiter. here we studied a case of mild hypothyroidism caused by a novel missense mutation in the thyroglobulin (tg) gene. a female patient underwent thyroidectomy twice at the age of 27 and 43 years because of gradual enlargement of the thyroid. by rnase cleavage assay and pcr direct sequencing we identified a thymine to cytosine transition at nucleotide 3828 (from the transcription start site) which causes amino acid change from ... | 1998 | 9790265 |
| thyroxine (t4) metabolism in an athyreotic patient who had taken a large amount of t4 at one time. | as we had an opportunity to take blood samples from a totally thyroidectomized patient who had attempted suicide by taking 2,000 microg of levothyroxine (l-t4), the serum levels of thyroid hormones were sequentially measured to investigate the metabolism of circulating thyroid hormones in an athyreotic human. the serum concentrations of most thyroid hormones reached a peak on the second day, but the serum t3 level showed a peak one day later. the maximum concentrations of t4 (315 microg/l), ft4 ... | 1998 | 9790272 |
| amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis. | we present a 25-year-old woman with amyloid goiter due to hypersensitivity vasculitis, who developed transient thyrotoxicosis resembling subacute thyroiditis. she received prednisolone (20 mg/ day) for three years for hypersensitivity vasculitis, and was diagnosed as having secondary amyloidosis by biopsies of the stomach, rectum and kidneys. she noticed neck swelling with severe right neck tenderness, palpitation, hyperhidrosis and weight loss. an elastic firm diffuse goiter was palpable, and t ... | 1998 | 9790279 |
| long term results of primary radiotherapy with/without neck dissection for squamous cell cancer of the base of tongue. | there are several management options for patients with squamous cell cancer of the base of tongue. we have had an interest in using primary radiotherapy with or without neck dissection, in an effort to provide optimal oncologic as well as functional outcomes. | 1998 | 9790286 |
| single-stranded dna binding properties of the uvsx recombinase of bacteriophage t4: binding parameters and effects of nucleotides. | bacteriophage t4 provides an important model for the biochemistry and genetics of dna metabolism. phage-encoded proteins conduct all essential steps of t4 dna replication, repair, and recombination. central to these three processes is the t4 uvsx protein, a member of the filamentous, atp-dependent class of general recombination enzymes typified by the escherichia coli reca protein. like reca, uvsx forms presynaptic filaments on single-stranded (ss) dna, which are the obligatory nucleoprotein int ... | 1998 | 9790840 |
| identification of the nuclease active site in the multifunctional recbcd enzyme by creation of a chimeric enzyme. | the recombinational hot spot chi modulates the nuclease and helicase activities of the recbcd enzyme, leading to generation of an early dna intermediate for homologous recombination. here we identify the subunit location of the nuclease active site in recbcd. the isolated recb protein cleaves circular single-stranded m13 phage dna, but recb1-929, comprising only the 100 kda n-terminal domain of recb, does not. we reported previously that the reconstituted recb1-929cd enzyme also is not a nucleas ... | 1998 | 9790841 |
| interaction of recbcd enzyme with dna at double-strand breaks produced in uv-irradiated escherichia coli: requirement for dna end processing. | the recbcd enzyme has a powerful duplex dna exonuclease activity in vivo. we found that this activity decreased strongly when cells were irradiated with uv light (135 j/m2). the activity decrease was seen by an increase in survival of phage t4 2(-) of about 200-fold (phage t4 2(-) has defective duplex dna end-protecting gene 2 protein). the activity decrease depended on excision repair proficiency of the cells and a postirradiation incubation. during this time, chromosome fragmentation occurred ... | 1998 | 9791113 |
| delineation of an evolutionary salvage pathway by compensatory mutations of a defective lysozyme. | model-free approaches (random mutagenesis, dna shuffling) in combination with more "rational," three-dimensional information-guided randomization have been used for directed evolution of lysozyme activity in a defective t4 lysozyme mutant. a specialized lysozyme cloning vector phage, derived from phage lambda, depends upon t4 lysozyme function for its ability to form plaques. the substitution w138p in t4 lysozyme totally abolishes its plaque-forming ability. compensating mutations in w138p t4 ly ... | 1998 | 9792108 |
| continuous positive airway pressure requirement during the first month of treatment in patients with severe obstructive sleep apnea. | (1) to compare the continuous positive airway pressure (cpap) requirement at the time of diagnosis (t0), after 2 weeks (t2), and after 4 weeks (t4) of cpap treatment, in patients with severe obstructive sleep apnea (osa); and (2) to assess whether any alteration in cpap requirement over the first 4 weeks of cpap treatment would influence daytime alertness, subjective sleepiness, or mood. | 1998 | 9792578 |
| cloning of a novel member of the udp-galactose:beta-n-acetylglucosamine beta1,4-galactosyltransferase family, beta4gal-t4, involved in glycosphingolipid biosynthesis. | a novel putative member of the human udp-galactose:beta-n-acetylglucosamine beta1,4-galactosyltransferase family, designated beta4gal-t4, was identified by blast analysis of expressed sequence tags. the sequence of beta4gal-t4 encoded a type ii membrane protein with significant sequence similarity to other beta1,4-galactosyltransferases. expression of the full coding sequence and a secreted form of beta4gal-t4 in insect cells showed that the gene product had beta1,4-galactosyltransferase activit ... | 1998 | 9792633 |
| allosteric regulation of vaccinia virus ribonucleotide reductase, analyzed by simultaneous monitoring of its four activities. | as determined by simultaneous monitoring of its four activities, vaccinia virus-coded ribonucleoside diphosphate (rndp) reductase shows responses to individual nucleoside triphosphate effectors-atp, datp, dgtp, and dttp-similar to those previously reported for rndp reductase of mouse, which the viral enzyme closely resembles. this investigation uses the vaccinia enzyme as a readily available and convenient model for understanding the cellular enzyme. as previously reported for t4 phage aerobic r ... | 1998 | 9792658 |
| comparison of the effects of thyroxine and triiodothyronine on protein turnover and apoptosis in primary chick muscle cell cultures. | primary chick muscle cells were treated with physiological level of thyroxine (t4) or triiodothyronine (t3) to examine the effects of the hormones on growth, protein turnover, and apoptosis of the cells. creatine kinase activity, as an index of differentiation, was increased by both t4 and t3. even when the conversion from t4 to t3 was blocked by iopanoic acid, t4 increased creatine kinase activity. the rate of protein degradation estimated from [3h] tyrosine release was increased by t3 but not ... | 1998 | 9792793 |
| [prevalence of endemic goiter in the health sector of zitenga (burkina faso)]. | the prevalence of iodine deficiency disorders (idd) was studied in the health district of zitenga village (oubritenga province, burkina faso), as part of an assisted development program. the study was designed to assess the prevalence of idd in a population of more than 2,000 people. a multistage cluster sample of 210 people was randomly selected. the women in the sample were aged 0 to 45 years and the men, 0 to 25 years. clinical and laboratory results (circulating tsh concentration, t4 and iod ... | 1998 | 9794037 |
| direct measurement of the contributions of type i and type ii 5'-deiodinases to whole body steady state 3,5,3'-triiodothyronine production from thyroxine in the rat. | production of t3 from t4 in tissues is catalyzed by two 5'-deiodinases, type i (d1) and type ii (d2), but the quantitative contribution of each pathway to whole body t3 production is not well established. in the presence of propylthiouracil (ptu), d1, but not d2, can be effectively blocked, providing an experimental probe for addressing this problem. decades ago, this approach provided indirect estimates ranging from 23-44% contribution by d2, based on plasma t3 appearance rate comparisons (par3 ... | 1998 | 9794474 |
| outcome of graves' disease after antithyroid drug treatment in taiwan. | the outcome of graves' disease after treatment with antithyroid drugs (atds) varies widely among countries, and large-scale studies in asia are rare. we investigated the associations of various clinical and laboratory features with the outcome of atd therapy for graves' disease in taiwan. a total of 210 patients (177 women, 33 men; mean +/- sd age, 41.7 +/- 15.1 yr) treated with atd in taiwan were included. atd therapy started with methimazole 30 mg daily or propylthiouracil 300 mg daily and was ... | 1998 | 9795530 |
| polymorphism within the cyclin d1 gene is associated with prognosis in patients with squamous cell carcinoma of the head and neck. | we have examined the correlation of a frequent a/g polymorphism within exon 4 of the cyclin d1 gene (ccnd1) with genetic susceptibility and clinical outcome in 384 patients with squamous cell carcinoma (scc) of the head and neck. ccnd1 genotype frequencies were similar in the cases and 191 controls. furthermore, the ccnd1 genotype was not associated with susceptibility to scc of the larynx, pharynx, or oral cavity. the influence of the ccnd1 genotype on clinical outcome was also assessed. we fou ... | 1998 | 9796972 |
| neonatal transient hypothyroidism: aetiological study. italian collaborative study on transient hypothyroidism. | to define the aetiology of neonatal transient hypothyroidism (nth) and recommend preventive measures. | 1998 | 9797631 |
| vertebral fracture assessment using the lateral scoutview of computed tomography in comparison with radiographs. | semiquantitative vertebral fracture assessment was compared between lateral computed tomography (ct) scoutviews and conventional thoracolumbar spinal radiographs. vertebral levels t4-l4 were assessed by both techniques in a group of 56 women (mean age 60 +/- 13 years). in order to compare inter- and intra-observer variabilities for the two techniques, the images were analyzed twice by two independent observers, and percentage agreement and kappa statistics were measured both between readings and ... | 1998 | 9797902 |
| activity of foreign proteins targeted within the bacteriophage t4 head and prohead: implications for packaged dna structure. | the phage-derived expression, packaging, and processing (pepp) system was used to target foreign proteins into the bacteriophage capsid to probe the intracapsid environment and the structure of packaged dna. small proteins with minimal requirements for activity were selected, staphylococcal nuclease (sn) and green fluorescent protein (gfp). these proteins were targeted into the t4 head by means of ipiii (internal protein iii) fusions or cts (capsid targeting sequence) fusions. additional evidenc ... | 1998 | 9799633 |
| the prognostic value of proliferating cell nuclear antigen (pcna) in the advanced cancer of larynx. | it was retrospectively examined whether the tumor growth fraction determined by pcna score in the advanced cancer of larynx could be used as a prognostic factor. there was used immunohistochemical method to evaluate the pcna score of positive cells in paraffin embedded tissues of laryngeal carcinoma obtained from 90 patients. they were treated by surgery in the department of otolaryngology at the medical university in cracow, poland in 1987 and 1988. the follow-up period was not shorter than 5 y ... | 1998 | 9799997 |
| plasma concentrations of thyroid hormones in growing pullets and laying hens reared under two tropical climates and fed on diets with different energy concentrations. | 1. blood samples were taken from growing (14-week-old) and laying (36-week-old) hens reared in either a temperate or a hot, humid climate and fed on 2 dietary energy concentrations (10.03 or 11.7 mj me/kg) to determine the plasma concentrations of 3,3',5'-triiodothyronine (t3) and thyroxine (t4) by radioimmunoassay. 2. plasma t3 concentrations were higher in birds fed on the low energy diet and higher at 14 than at 36 weeks of age, while the effects of climate were complex. 3. plasma t4 concentr ... | 1998 | 9800048 |
| tonsillar carcinoma: analysis of treatment results. | early stage squamous cell carcinoma of the tonsil is amenable to treatment by either surgery or radiation therapy as a single modality, with comparable rates of local control. unfortunately, manifestation of the disease at an early stage is infrequent, and surgery or radiation alone is less successful in controlling advanced disease. this study was conducted to elucidate the optimal treatment plan for advanced stages of tonsillar carcinoma and to identify significant risk factors for development ... | 1998 | 9800624 |
| mechanisms of vascular growth-promoting effects of neuropeptide y: role of its inducible receptors. | we have previously reported that neuropeptide y (npy), a sympathetic cotransmitter and vasoconstrictor, is mitogenic for vascular smooth muscle cells (vsmcs), and now report on the mechanisms mediating these effects. in rat aortic a10 cell line, npy's potency was greater than that of norepinephrine, and efficacy similar to that of platelet-derived growth factor, but less than that of the full serum, in stimulating cell proliferation; this effect was optimal in cell 60-80% cell density. at lower ... | 1998 | 9802414 |
| [right sensory-motor syndrome as the presentation of a spontaneous cervico-thoracic epidural hematoma]. | a spontaneous cervical epidural hematoma is an infrequent cause of cord compression. the commonest clinical presentations are with paraparesia and tetraparesia. transient hemiparesia is very rare and a sensory-motor syndrome is exceptional. | 1998 | 9803502 |
| effect of haptoglobin phenotypes on growth of streptococcus pyogenes. | the haptoglobin (hp) 2-1 and 2-2 phenotypes have been shown to agglutinate streptococcus pyogenes carrying the membrane antigen t4. in this study, the growth rate of two strains of streptococcus pyogenes (t1 and t4) in human serum was compared among haptoglobin phenotypes in vitro. during incubation for 16 hours in serum of different haptoglobin types, only hp 2-1 and hp 2-2 sera showed an inhibitory effect on growth, hp 2-2 being 1.85 times more potent than hp 2-1. growth of streptococcus pyoge ... | 1998 | 9804392 |
| role of ascorbic acid in cadmium-induced thyroid dysfunction and lipid peroxidation. | a study on the effects of ascorbic acid (aa) on heavy metal (cadmium)-induced thyroid dysfunction and lipid peroxidation (lpo) was carried out in swiss male mice. the animals were administered with either cadmium (1.0 mg kg(-1) body wt.) alone or in combination with aa (1 mm) every day for 15 days. while cadmium treatment led to a decrease in the serum concentrations of thyroid hormones and hepatic type i iodothyronine 5'-monodeiodinase (5'd-i) activity, an increase in the level of lipid peroxid ... | 1998 | 9804431 |
| cloning of a human udp-n-acetyl-alpha-d-galactosamine:polypeptide n-acetylgalactosaminyltransferase that complements other galnac-transferases in complete o-glycosylation of the muc1 tandem repeat. | a fourth human udp-galnac:polypeptide n-acetylgalactosaminyltransferase, designated galnac-t4, was cloned and expressed. the genomic organization of galnac-t4 is distinct from galnac-t1, -t2, and -t3, which contain multiple coding exons, in that the coding region is contained in a single exon. galnac-t4 was placed at human chromosome 12q21.3-q22 by in situ hybridization and linkage analysis. galnac-t4 expressed in sf9 cells or in a stably transfected chinese hamster ovary cell line exhibited a u ... | 1998 | 9804815 |
| [the general practitioner and abnormal thyroid function screening]. | the high frequency of thyroid diseases justifies the measurement of serum tsh in regular checkups. if found normal in non-goitrous patients, this measurement is self-sufficient, but pregnant women should also be screened for antithyroid antibodies because they have an increased risk of post-partum hashimoto's disease. abnormal tsh concentrations suggesting hyperthyroidism (tsh < 0,3 mu/l) or hypothyroidism (tsh > 5 mu/l) need free t4 and free t3 complementary determinations, and positive anti-th ... | 1998 | 9805952 |
| a novel dna-binding motif shares structural homology to dna replication and repair nucleases and polymerases. | a novel class of dna-binding domains has been established from at least sixteen recently identified dna-binding proteins. the three-dimensional structure of one of these domains, mrf-2, has been solved using nmr methods. this structure is significantly different from known dna-binding domain structures. the mechanism of dna recognition by this motif has been suggested based on conserved residues, surface electrostatic potentials and chemical shift changes. this new dna-binding motif shares struc ... | 1998 | 9808040 |
| epidural anaesthesia for caesarean delivery in triple and quadruple pregnancies. | mechanical and/or hormonal factors may increase the spread of epidural anaesthesia in pregnancy, and hormonal changes are more pronounced in high-order pregnancies. however, no previous study has evaluated the dose requirements and haemodynamic effects of epidural anaesthesia for caesarean delivery in this latter situation. | 1998 | 9809093 |
| thyroid function during and after cardiopulmonary bypass in children. | the aim of the study was to elucidate the changes in thyroid function during and after cardiopulmonary bypass (cpb) in children. | 1998 | 9809096 |
| the thyrotropin-releasing hormone-like peptides pglu-phe-pro amide and pglu-glu-pro amide increase plasma triiodothyronine levels in the mouse; the activity is sensitive to testosterone. | three naturally occurring peptides, pglu-glu-pro amide, pglu-phe-pro amide and pglu-gln-pro amide, with similar structures to thyrotropin releasing hormone (trh) have recently been identified but no studies of their in vivo activities have been reported previously. we describe here the ability of pglu-phe-pro amide and pglu-glu-pro amide to influence thyroid status. subcutaneous administration of these 'trh-like' peptides in male and female cdi mice led to increased levels of triiodothyronine (t ... | 1998 | 9809870 |
| radical cystectomy for invasive bladder cancer--a local experience. | the aim of this study of patients undergoing cystectomy for invasive transitional cell carcinoma of the bladder was to compare clinical and pathological staging and to review factors that predict survival. | 1998 | 9810218 |
| [adjuvant and neoadjuvant therapy of rectal carcinoma. the current status]. | the consensus conference of the german cancer society (cao/aio/aro, 1.7.1998) has recently updated recommendations for patients with rectal cancer. instead of a former reservation regarding the indication of adjuvant therapy for rectal cancer the actual version of the consensus particularly emphasizes the role of postoperative radiochemotherapy for stage-ii/iii tumors. this article reviews the most recent and ongoing trials of adjuvant and neoadjuvant therapy of rectal cancer. | 1998 | 9810316 |
| changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. | the importance of ashwagandha root extract in the regulation of thyroid function with special reference to type-i iodothyronine 5'-monodeiodinase activity in mice liver has been investigated. although the root extract (1.4 g kg(-1)) administered daily for 20 days by gastric intubation increased serum 3,3',5-triiodothyronine (t3) and tetraiodothyronine (t4) concentrations and hepatic glucose-6-phosphatase activity, hepatic iodothyronine 5'-monodeiodinase activity did not change significantly. fur ... | 1998 | 9811169 |
| h19 overexpression in breast adenocarcinoma stromal cells is associated with tumor values and steroid receptor status but independent of p53 and ki-67 expression. | in a previous study we described the expression of the h19 gene by in situ hybridization (ish) in normal breast and in benign or malignant breast tumors (dugimont t, curgy jj, wernert n, delobelle a, raes mb, joubel a, stehelin d, coll j: biol cell 1995, 85:117-124). in the present work, 1) we extend the previous one to a statistically useful number of adenocarcinomas, including 10 subclasses, 2) we provide information on the precise ish localization of the h19 rna by using, on serial tissue sec ... | 1998 | 9811352 |
| effect of pharmacologically induced changes in milk ejection on suckling in bos taurus. | this experiment was to test the hypothesis that suckling behavior in bos taurus is related to milk ejection. intra-gland milk transport was manipulated by applying four different treatments to four cow-calf pairs: t1, injection of oxytocin during the post-stimulation period; t2, injection of oxytocin before a meal; t3, injection of saline solution at the same times as oxytocin was applied (control) in t1 and t2; t4, injection of an oxytocin antagonist in a similar way as t1. drugs were applied i ... | 1998 | 9811377 |
| replicative functions of minute virus of mice ns1 protein are regulated in vitro by phosphorylation through protein kinase c. | ns1, the major nonstructural protein of the parvovirus minute virus of mice, is a multifunctional phosphoprotein which is involved in cytotoxicity, transcriptional regulation, and initiation of viral dna replication. for coordination of these various functions during virus propagation, ns1 has been proposed to be regulated by posttranslational modifications, in particular phosphorylation. recent in vitro studies (j. p. f. nüesch, r. corbau, p. tattersall, and j. rommelaere, j. virol. 72:8002-801 ... | 1998 | 9811734 |
| protein antimicrobial barriers to bacterial adhesion. | the ability of microorganisms to adhere to solid surfaces is a problem of high visibility and has been the focus of numerous investigations because these organisms can cause disease and food spoilage. during the last several years, considerable attention has been focused on the development of food-grade antimicrobial barriers to adhesion in order to inhibit the initial adhesion of microbial contaminants by application of an antimicrobial agent to the surface rather than trying to remove these co ... | 1998 | 9812283 |
| [controlled clinical trials of hyperfractionated and accelerated radiotherapy in otorhinolaryngologic cancers]. | from 1978 to march 1998, (1,867 patients) were accrued in head and neck trials comparing hyperfractionation (hf) and accelerated fractionation (af) to classical fractionation (cf). two randomized trials (867 pts) led to positive conclusions in favour of the hf & af arms: 1) eortc trial 22791 (356 patients, 1980-87) compared cf (70 gy/35-40 fr/7-8 wks) to hf (80.5 gy/70 fr/7 wks, using 2 fr x 1.15 gy/day) in t2 t3, n0-n1 < 3 cm in oropharyngeal carcinoma. locoregional control (lrc) was higher (p ... | 1998 | 9812410 |