Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| endothoracic sonography with color doppler availability during video assisted thoracic surgery (videothoracoscopic operative staging with ultrasound color doppler) for lung cancer staging. | the preoperative staging of lung cancer can be problematical when we attempt to evaluate t factor (t2-t3 versus t4) and n factor (n0 versus n1-n2). in some cases, radiology tests (ct scan, magnetic resonance imaging) cannot entirely dispel the possibility that the mediastinal structures have been infiltrated. n factor is evaluated mainly by dimensional criteria. however, mediastinoscopy and mediastinotomy do not allow the full exploration of all mediastinal mode stations. | 1998 | 9601997 |
| effects of cisatracurium in children during halothane-nitrous oxide anesthesia. | to determine the neuromuscular blocking effect and recovery profile of cisatracurium besylate in children after administration of a bolus dose that was twice the estimated dose required to produce 95% of the maximum effect (2 x ed95; 0.08 mg/kg) followed by an infusion during halothane-nitrous oxide anesthesia. | 1998 | 9603588 |
| occurrence of a sequence in marine cyanophages similar to that of t4 g20 and its application to pcr-based detection and quantification techniques. | viruses are ubiquitous components of marine ecosystems and are known to infect unicellular phycoerythrin-containing cyanobacteria belonging to the genus synechococcus. a conserved region from the cyanophage genome was identified in three genetically distinct cyanomyoviruses, and a sequence analysis revealed that this region exhibited significant similarity to a gene encoding a capsid assembly protein (gp20) from the enteric coliphage t4. the results of a comparison of gene 20 sequences from thre ... | 1998 | 9603813 |
| effect of storage conditions on cortisol, total thyroxine, and free thyroxine concentrations in serum and plasma of dogs. | to determine for dogs stability of cortisol, thyroxine (t4), and free thyroxine (ft4) in plasma and serum stored in glass or plastic tubes at -20, 4, 25, and 37 c. | 1998 | 9604024 |
| effect of time of sample collection on serum thyroid-stimulating hormone concentrations in euthyroid and hypothyroid dogs. | to determine effect of time of sample collection on serum thyrotropin (canine thyroid-stimulating hormone [ctsh]) concentrations in euthyroid and hypothyroid dogs. | 1998 | 9604026 |
| reduced serum t3 level in a patient with nodular goiter and cardiac myxoma. | we report the unusual case of an 87-year-old woman with cardiac myxoma and adenomatous goiter. she exhibited slight elevations of serum interleukin-6 (il-6), but levels of thyroid hormones such as t3, free t3 and free t4 were all abnormally low. interleukin-6 may potentiate the alteration of thyroid metabolism. | 1997 | 9604790 |
| the value of cyfra 21-1, a new tumor marker, in nasopharyngeal carcinoma. | cyfra 21-1 (cyfra) is a newly-developed tumor marker which is useful in evaluating non-small cell lung carcinoma, especially the squamous cell type. the purpose of this study was to assess the clinical value of cyfra in patients with nasopharyngeal carcinoma (npc). serum levels of cyfra (cis bio-international, france) were measured in 80 patients with untreated npc. the histologic diagnosis of all patients was confirmed by biopsy. twenty two (27.5%) of the tumors were classified as undifferentia ... | 1998 | 9604997 |
| use of the single-cell gel electrophoresis assay for the immunofluorescent detection of specific dna damage. | the single-cell gel electrophoresis assay or comet assay is now a widely used method to assess the level of dna damage in irradiated or chemically modified cells. we propose an adaptation of the currently applied protocol, aimed at singling out a defined modified base, using an immunodetection approach. after the electrophoresis step, the dna tail moment was measured using ethidium bromide. simultaneously, cyclobutane pyrimidine dimers (cpds), the targeted lesions, were revealed by an indirect i ... | 1998 | 9606136 |
| differences in thyroid function between bipolar manic and mixed states. | high rates of thyroid axis abnormalities have been reported in most studies of patients with rapid-cycling bipolar disorder. mixed states share similarities with rapid-cycling, including close temporal occurrence of manic and depressive symptoms, predominance in women, poor outcome, and less robust response to lithium compared with pure mania; however, thyroid axis abnormalities have not been well studied in mixed mania. | 1998 | 9606526 |
| endocrine responses to weaning and changes in post-weaning diet in the young pig. | the effects of weaning and changing post-weaning diet composition on growth patterns and growth-related hormonal profiles were evaluated in neonatal pigs. forty-eight crossbred piglets were assigned to two groups (n = 24/group) based on weaning at 2 or 3 wk of age (2w and 3w groups. respectively). at weaning, piglets were removed from the sow and placed on a commercial starter ration for the first 11 d post-weaning (phase i diet). at day 12 post-weaning, pigs were placed on a growing ration for ... | 1998 | 9606600 |
| value of sextant biopsies in the assessment of local cure following external beam radiotherapy of prostatic adenocarcinoma. | between 1982 and 1992, 73 patients received radical external beam radiotherapy (ebr) for prostatic adenocarcinoma at the central hospital, västerås, with an average dose of 68.1 gy (range 64.5-72.5 gy) and an average cumulative radiation effect (cre) of 18.2 (range 17.1-19.9) all patients had a negative bone scan prior to treatment and presented with clinical stage t1-t4,nx,mo. twenty-four out of 36 surviving patients consented to participate in a follow-up study which included transrectal, ultr ... | 1998 | 9606782 |
| [endoscopic ultrasonography in the staging of esophageal cancer. therapeutic implications]. | endoscopic ultrasonography (eus) provides accurate visualization of the different layers of the gastrointestinal wall and surrounding structures, allowing tn staging of tumors prior surgery. the aim of this study was to evaluate the sensitivity, specificity and accuracy of eus in the staging of esophageal carcinoma as well as its applicability and usefulness in tumors with nontraversable stenoses. eus was performed in 43 patients with esophageal carcinoma. the technique was carried out with a ra ... | 1998 | 9607290 |
| antiparallel dna duplex formation between alternating alpha d(ga)n and beta d(ga)n sequences. | alternating polypurine d(ga)n, sequences exhibit a considerable polymorphism. here we report that alpha d(ga) x d(ga) sequences form an antiparallel stranded duplex dna at neutral ph. the spectroscopic, electrophoretic and thermodynamic properties of the alpha/beta chimeric oligodeoxynucleotide, 5'-d(ga)4(t)4 alpha d(ag)4t-3', support the formation of a hairpin structure with antiparallel strands in the stem. the optical properties of this novel antiparallel structure are different from the para ... | 1998 | 9607333 |
| ethmoid sinus cancer: twenty-nine cases managed with primary radiation therapy. | to describe the outcome of patients with carcinoma of the ethmoid sinus managed with a policy of primary radiation therapy with surgery for salvage of persistent or progressive disease. | 1998 | 9607352 |
| locally recurrent nasopharyngeal carcinoma: treatment results for patients with computed tomography assessment. | to study the treatment outcome in patients with locally recurrent nasopharyngeal carcinoma as restaged by computed tomography (ct). | 1998 | 9607354 |
| preoperative serum vascular endothelial growth factor can predict stage in colorectal cancer. | neovascularization has been shown to be essential for the growth of solid tumors. vascular endothelial growth factor (vegf) is one of the most important mediators of angiogenesis. this study was conducted to determine the significance of this cytokine as a tumor marker for staging colorectal cancer. preoperative serum vegf was measured in 108 colorectal cancer patients and in 136 normal healthy controls. the results of this study showed a significant difference between the four t classes, union ... | 1998 | 9607588 |
| fasting-induced increase in type ii iodothyronine deiodinase activity and messenger ribonucleic acid levels is not reversed by thyroxine in the rat hypothalamus. | the importance of local formation of t3 in the feedback effect of the thyroid gland on hypothalamic trh-producing cells has been established. primary failure of the thyroid gland results in a fall in circulating t4 and t3 levels, leading to an elevation in the production and release of trh in the hypothalamic paraventricular nucleus. in contrast, during short term fasting, declining plasma levels of thyroid hormones coincide with suppressed trh production and release. in the brain, the prevalent ... | 1998 | 9607797 |
| the decrease of liver ldl receptor mrna during fasting is related to the decrease in serum t3. | fasting is associated with a reduction in serum t3 and t4 and a rise of plasma ldl cholesterol. we hypothesized that an hypothyroid-like condition induced by fasting is responsible for the rise in ldl cholesterol. we therefore examined the relation between changes in thyroid hormone and cholesterol metabolism in rats fasted for 0, 8, 12, 24 or 48 h. fasting resulted in a decrease of liver 5'-deiodinase mrna from 8 h (to 50%, p < 0.05, n = 6), of serum t3 from 12 h and of serum t4 at 48 h; serum ... | 1998 | 9608674 |
| nocturnal increases in the triiodothyronine/thyroxine ratio in the rat thymus and pineal gland follow increases of type ii 5'-deiodinase activity. | the type ii 5'-deiodinase (5'd-ii) is regulated by the light-dark cycle in some tissues in which the enzyme is present. this prompted us to investigate putative influences of light-dark cycle on thyroid hormone concentrations in these tissues. the results revealed the following facts: (a) deiodinase activity in the rat thymus exhibits a nyctohemeral profile with peak values late at night and basal values during the day. the thyroid hormone concentrations in the thymus also show a 24 h rhythm wit ... | 1998 | 9608677 |
| flexibility of the thyroiditogenic t cell repertoire for murine autoimmune thyroiditis in cd8-deficient (beta2m -/-) and t cell receptor vbeta(c) congenic mice. | in murine experimental autoimmune thyroiditis (eat), previous studies have revealed a highly adaptable thyroiditogenic t cell repertoire which involves both cd4+ and cd8+ t cells in the susceptible h2k strain. to further test this flexibility, congenic b10.k mice lacking cd8+ t cells (b2m -/-) or harboring 70% t cell receptor (tcr) vbeta gene deletions (vbeta(c)) were immunized with mouse thyroglobulin (mtg) and evaluated for eat 28 days later. all b2m -/- mice developed moderate antibodies to m ... | 1998 | 9609129 |
| transmural care of terminal cancer patients: effects on the quality of life of direct caregivers. | the burden of caring for terminal cancer patients has a negative effect on the informal caregivers' quality of life. | 1998 | 9610646 |
| thyroid function in postmenopausal women with breast cancer on tamoxifen. | in 42 postmenopausal women with breast cancer, aged 48-85 years (mean age 62.4 years) serum thyroid hormone concentrations were measured before and after 6 months of tamoxifen therapy (20 mg daily). in particular triiodothyronine (t3), thyroxine (t4), free triiodothyronine (ft3), free thyroxine (ft4), thyroxine-binding globulin (tbg) and thyroid-stimulating hormone (tsh) concentrations before and 30 minutes after thyrotrophin-releasing hormone (trh) administration (200 microg i.v.) were measured ... | 1998 | 9611055 |
| characterization of werner syndrome protein dna helicase activity: directionality, substrate dependence and stimulation by replication protein a. | werner syndrome is an inherited disease characterized by premature aging, genetic instability and a high incidence of cancer. the wild type werner syndrome protein (wrn) has been demonstrated to exhibit dna helicase activity in vitro. here we report further biochemical characterization of the wrn helicase. the enzyme unwinds double-stranded dna, translocating 3'-->5' on the enzyme-bound strand. hydrolysis of datp or atp, and to a lesser extent hydrolysis of dctp or ctp, supports wrn-catalyzed st ... | 1998 | 9611231 |
| [combined deficiency of thyroid stimulating hormone and growth hormone in a diabetic patient with hashimoto thyroiditis]. | we report the case of a 36-year-old female patient with insulin dependent diabetes who developed hypothyroidism of pituitary origin after giving birth. she had low levels of free t4 and tsh with no response to i.v. trh. antimicrosome antibodies were increased (1/25000), suggesting hashimoto's thyroiditis. the other hormones were normal except for a low level of growth hormone and insulin growth factor 1. there were no antibodies against the pituitary. mri of the pituitary was normal. we suspect ... | 1998 | 9614334 |
| pre-autoimmune thyroid abnormalities in the biobreeding diabetes-prone (bb-dp) rat: a possible relation with the intrathyroid accumulation of dendritic cells and the initiation of the thyroid autoimmune response. | thyroid autoimmune reactions start with an accumulation of mainly dendritic cells in the thyroid. there is increasing evidence that, apart from being antigen-presenting cells, they are also able to control the growth and hormone synthesis of neighbouring endocrine cells. the questions thus arise: are dendritic cells accumulating in the pre-autoimmune thyroid in response to an altered proliferative or metabolic activity of thyrocytes, and do cytokines, monocyte chemoattractants, or both, have a r ... | 1998 | 9614356 |
| antenatal triiodothyronine improves neonatal pulmonary function in preterm lambs. | to characterize 1) pulmonary gas exchange, 2) pulmonary function, 3) lung fluid and tissue phospholipid content, and 4) thyroid hormone in the premature lamb (0.85 of term) after intra-amniotic administration of 100 micrograms of triiodothyronine (t3) 2 weeks before delivery. | 1998 | 9614640 |
| [locally advanced prostate carcinoma (t2b-t4 n0) without and with clinical evidence of local progression (tx n+) with lymphatic metastasis. is radiotherapy for pelvic lymphatic metastasis indicated or not?]. | there is a greater controversy regarding the indication of radiotherapy of the pelvic lymphatics in patients with suspected lymph node metastases in locally advanced prostate cancer (t2b-4 n0) on the one hand and in patients with pathologically proven lymph node metastases in locoregional advanced prostate cancer (tx pn+) on the other hand following definitive radiotherapy and radical prostatectomy. this paper investigates the possible indications for radiotherapy of the pelvic lymphatics in the ... | 1998 | 9614950 |
| effects of 6-n-propyl-2-thiouracil on growth, hormonal profiles, carcass and reproductive traits of boars. | neonatal 6-n-propyl-2-thiouracil (ptu)-induced hypothyroidism reduces body weight but increases testicular size in adult male rodents. the objective of this study was to determine the effect of prepubertal ptu treatment on boars. for experiment i, boars (n = 28) were randomly allotted to eight pens. each pen received one of four ptu doses (0, 0.01, 0.03 and 0.1% in a basal diet) between 28 and 56 days of age (doa). due to a lack of difference among three ptu treatments, ptu-treated boars were po ... | 1998 | 9615182 |
| changes in circulating lh, sex steroid hormones, thyroid hormones and corticosterone in relation to breeding and molting in captive humboldt penguins (spheniscus humboldti) kept in an outdoor open display. | penguins are highly adapted to marine life. their hydrodynamic efficiency depends on feathers which wear with age and need to be replaced regularly. during molting, penguins can not enter the sea to forage and are forced to fast. therefore the duration of molting is necessarily brief. to better understand molting in penguins, we collected plasma samples from 16 (8 pairs) humboldt penguins kept in an open display pen at tokyo sea life park from may to september, 1994 and estimated circulating con ... | 1998 | 9615622 |
| thyroid hormone concentrations and muscle metabolism in amenorrheic and eumenorrheic athletes. | the relationship between resting thyroid hormone concentrations and exercise muscle metabolism was examined among eumenorrheic endurance-trained (n = 11), amenorrheic endurance-trained (n = 8), and eumenorrheic nonathletic (n = 13) subjects. muscle metabolism was assessed with 31phosphorous magnetic resonance spectroscopy by measuring changes in phosphocreatine (pcr), inorganic phosphate (pi), and ph during plantar flexion exercise and recovery. all groups had similar pi/pcr ratios and ph change ... | 1998 | 9615871 |
| effect of thyroid hormone on plasma apolipoproteins and apoa- and apob-containing lipoprotein particles. | apolipoprotein and apob- and apoa-containing lipoprotein particle concentrations were determined in 10 athyreotic patients 4 weeks after withdrawal of synthroid replacement therapy [t4, 0.96 +/- 0.66 microgram ml-1; thyroid-stimulating hormone (tsh), 62.7 +/- 22.8 muiu ml-1] and again 4 weeks after reinstitution of treatment. | 1998 | 9615901 |
| breast cancer in patients treated for hodgkin's disease: clinical and pathological analysis of 76 cases in 63 patients. | in a retrospective multicentric analysis, 63 women treated between 1941 to 1988 for hodgkin's disease (hd) subsequently developed 76 breast cancers (bc). the median age at diagnosis of hd was 26 years (range 7-67), and 22 women (35%) were 20 years old or less. exclusive radiotherapy (rt) was used in 36 women (57%) and combined modalities with chemotherapy (ct) in 25 (39%). breast cancer occurred after a median interval of 16 years (range 2-40) and the median age at diagnosis of the first bc was ... | 1997 | 9616274 |
| bronchoalveolar lavage causes decrease in pao2, increase in (a-a) gradient value and bronchoconstriction in asthmatics. | the aims of this study were to (1) record the changes of (arterial oxygen partial pressure) pao2, (arterial carbon dioxide partial pressure) paco2, (percentage saturation of haemoglobin with oxygen in arterial blood) sao2 and alveolar-arterial (a-a) oxygen gradiant resulting from bronchoalveolar lavage (bal) in asthmatic and normal subjects; (2) measure changes in forced expiratory volume in 1 s (fev1), vital capacity forced (fvc) associated with bal; and (3) assess possible predictive factors f ... | 1998 | 9616511 |
| [combination of transcatheter arterial infusion of smancs and embolization (smancs-tae) for hepatocellular carcinoma--second report]. | patients with unresectable hepatocellular carcinoma (hepatoma) with hypervascularity were treated by smancs-tae. a superselective catheterization technique was used to inject gelatin sponge particles after administration of smancs. in 30 patients of first hepatoma treated by smancs-tae. grade 4 was obtained after 1.7(1-3) courses. the 2-year survival rate was 22%. some of the 24 patients of second hepatoma treated by smancs-tae have survived over 2 years. sixteen patients with advanced hepatoma ... | 1998 | 9617326 |
| [tnm classification of brain tumor]. | tm staging proposed by uicc was classified mainly by histology and tumor size (extension). staging trial was done by using the data of astrocytic tumor cases of the supratentorial region collected both during the periods between 1978 to 1987 by the brain tumor registry of japan (permission for publication: sep. 1994). survival curves classified by t classification in each histology, such as astrocytoma, malignant astrocytoma, glioblastoma, showed a great differences from each other, even at the ... | 1998 | 9617336 |
| a plant transformation vector with a minimal t-dna ii. irregular integration patterns of the t-dna in the plant genome. | a minimal t-dna binary vector was used for agrobacterium-mediated transfer of a chimeric t4 lysozyme gene located next to the left border, and transgenic potato plants which expressed t4 lysozyme protein were identified and further analysed. frequent rearrangements of t4 lysozyme transgenes were detected. a vector derivative containing two matrix associated regions (mars) flanking its multiple cloning site was constructed. in transgenic potato plants, reduced variability in gene expression due t ... | 1998 | 9617825 |
| quantitative reverse transcription strand displacement amplification: quantitation of nucleic acids using an isothermal amplification technique. | recent advances in nucleic acid amplification techniques have allowed for quantitation of viral nucleic acid levels in clinical specimens. the most prevalent testing is carried out for hiv viral load. strand displacement amplification (sda) is an isothermal dna amplification system utilizing a restriction enzyme and a dna polymerase with strand displacement properties. sda was adapted for quantitative rna amplification (qrt-sda) of an hiv gag sequence by including amv reverse transcriptase, a qu ... | 1998 | 9618201 |
| sucrase-isomaltase ontogeny: synergism between glucocorticoids and thyroxine reflects increased mrna and no change in cell migration. | during postnatal maturation of the rat small intestine, glucocorticoid hormones (gc) and thyroxine (t4) act synergistically to elicit a precocious increase of sucrase activity. the current work shows that the synergistic effect on sucrase activity is paralleled by increased steady-state levels of sucrase-isomaltase mrna. the enhancing effects of t4 on dexamethasone (dex)-induced sucrase activity was seen even after prolonged treatment (9 days). moreover, when the location of sucrase-bearing cell ... | 1998 | 9618286 |
| [axillary node removal in clinical node-negative breast carcinoma. can its indication be individualized by "sentinel node" detection?]. | the status of the axillary lymph node(s) is an important prognostic factor in breast cancer and thus decisive in the indication for adjuvant treatment. this study investigated the extent to which examination of the sentinel node (sn) can individualize the need for axillary resection and the diagnosis of lymph nodes be optimized. | 1998 | 9618639 |
| effect of selective substitution of 5-bromocytosine on conformation of dna triple helices. | three triplex dnas containing 5-bromocytosine[brc] were studied by vibrational spectroscopy and molecular modelling. firstly, three oligodeoxypyrimidines of 5'-(tc)3-t4-(brct)3 [cbrc], 5'-(tbrc)3-t4-(ct)3 [brcc] and 5'-(tbrc)3-t4-(brct)3 [brcbrc] were synthesized and then reacted with an oligodeoxypurine of 5'-(ag)3 at ph=4.5 in phosphate buffer respectively to form three comparative hairpin triplex named cy,yc and yy. the results of ft-raman and ir revealed that yy is almost in a-like form, cy ... | 1998 | 9619512 |
| rad52 forms ring structures and co-operates with rpa in single-strand dna annealing. | the rad52 epistasis group in saccharomyces cerevisiae is involved in various types of homologous recombination including recombinational double-strand break (dsb) repair and meiotic recombination. a reca homologue, rad51, plays a pivotal role in homology search and strand exchange. genetic analysis has shown that among members of its epistasis group, rad52 alone is required for recombination between direct repeats yielding deletions. very little has been discovered about the biochemical roles an ... | 1998 | 9619627 |
| infrapetiole exploration of the supraglottis for exposure of the anterior glottal commissure. | effective microlaryngoscopic surgery of the anterior glottal commissure depends on adequate exposure of this region. despite the use of elevated vector suspension and external laryngeal counter-pressure, there are some individuals in whom inadequate exposure precludes execution of the planned surgery. to solve this problem, a procedure was designed in which the anterior vestibular folds and the infrapetiole region of the supraglottis are resected to facilitate complete exposure of the broyle's l ... | 1998 | 9619988 |
| immunoregulatory mechanisms and stress hormones in psoriasis (part 1) | in an earlier paper, the author noted that psoriatic eruptions may be produced in phases of humoral and cellular immunodeficiency and in the presence of streptococcal antigen-releasing inflammatory foci. in this study it was investigated as to whether stress hormones glucocorticoids, catecholamines) are substantially involved in the activity phases (eruptions) of psoriasis. | 1998 | 9620481 |
| the effects of thyroid hormone modulation on rat liver injury associated with ischemia-reperfusion and cold storage. | we investigated the effects of thyroid hormone modulation on liver injury associated with ischemia-reperfusion (i-r) and cold storage in rats. first, euthyroid and thyroxine (t4)-pretreated rats were exposed in vivo to 20-min global liver ischemia, then 30-min reperfusion. liver injury was assessed by measuring serum alanine aminotransferase (alt) levels. liver concentrations of adenine nucleotides, reduced glutathione (gsh), and oxidized glutathione were evaluated. second, rats were given the a ... | 1998 | 9620501 |
| [the function of the thyroid and thyrotropic function in patients with chronic ischemic heart disease and rhythm disorders]. | measured in 119 patients with chronic heart disease (exercise-induced angina in 62, cardiosclerosis in 57 cases) presenting with arrhythmias (extrasystolic arrhythmia, permanent form cardiac fibrillation, association of cardiac fibrillation with ventricular arrhythmia, with n = 58, 38, 23 respectively) were blood levels of thyroid-stimulating hormone (tsh), triiodothyronine (t3) and thyroxin (t4) using immunoradiometric assay. in extrasystolic arrhythmia, permanent form cardiac fibrillation, the ... | 1998 | 9621622 |
| effect of protein and protein-free energy intake on plasma concentrations of insulin-like growth factor i and thyroid hormones in preruminant calves. | we conducted two experiments with preruminant calves weighing 80 to 240 kg to study the long-term nutritional regulation of circulating igf-i, thyroxine (t4), and triiodothyronine (t3). the two experiments were similar in design but were performed with calves of two live weight ranges: 80 to 160 kg (exp. 1) and 160 to 240 kg (exp. 2). in each experiment, 36 calves were allocated to one of 12 dietary treatments, which consisted of six protein intake levels at each of two energy intake levels. dig ... | 1998 | 9621941 |
| spuriously high free thyroxine with the access free t4 assay. | 1998 | 9622776 | |
| [diagnosis of bronchial carcinoma]. | in addition to conventional chest x-rays in ap and lateral projection, computed tomography of the chest, upper abdomen, and head, precutaneous ultrasonography of the abdomen, and bone scintigraphy represent the standard procedures for the primary diagnosis and staging of bronchial carcinoma. magnetic resonance imaging should be reserved for special situations and patients with allergy to i.v. contrast medium. the clinical value of positron emission tomography (pet) primarily with respect to lymp ... | 1998 | 9622819 |
| [urothelial carcinoma of the upper urinary tract. survival and prognostic factors]. | to analyze the survival and the main prognostic factors in patients with transitional cell carcinoma of the upper urinary tract. | 1998 | 9622915 |
| [dysphagia as a symptom of myxedema]. | we present a 79 year old female patient with dysphagia since two years. she showed also a lack of initiation and dysphonia. in the region of the larynx an edema was found and the tongue was hypertrophied. the x-ray examination demonstrated a dilated esophagus without impairment of the passage way. esophagoscopy showed also important edema in the hypopharynx and the entry into the esophagus. the tsh-0 was 74.45 mmu/l, the t3 0.23 and the t4 was 24 nmol/l. scintigraphically an only cherry-stone sm ... | 1998 | 9623334 |
| double-blind comparison of extradural block with three bupivacaine-ketamine mixtures in knee arthroplasty. | we have compared 0.5% bupivacaine 75 mg (group a; n = 15) with three 0.5% bupivacaine 75 mg-ketamine mixtures for extradural block in 59 asa i-iii patients undergoing total knee replacement in a randomized, double-blind study. the following doses of preservative-free 1% ketamine were used: 0.3 mg kg-1 (group b: n = 14); 0.5 mg kg-1 (group c: n = 5); and 0.67 mg kg-1 (group d: n = 15). level of sensory block, degree of motor weakness and sedation scores were recorded before and after operation. d ... | 1998 | 9623427 |
| insulin-like growth factor-binding protein-3 (igfbp-3) but not insulin-like growth factor-i (igf-i) remains elevated in euthyroid tsh-suppressed graves' disease. | thyroid hormones have been shown to be involved in the regulation of insulin-like growth factor-i (igf-i) and igf binding protein-3 (igfbp-3) expression. this is a cross-sectional study to look at the effects of thyroid hormone status on the circulating levels of igf-i and igfbp-3 in a group of 127 patients, aged 20-80 years, who were hyperthyroid, hypothyroid, rendered euthyroid and clinically euthyroid with normal free thyroxine (ft4), but suppressed thyroid stimulating hormone (tsh) levels. t ... | 1998 | 9623636 |
| the effects of thyroid status on serum apolipoprotein a-i-containing lipoprotein particles. | alterations of lipid profile are a well-known phenomenon in thyroid dysfunction. however, little is known about the influence of thyroid hormone on lp a-i and lpa-i:a-ii particles. we have, therefore, studied lpa-i and lpai:a-ii concentrations in a group of 20 patients with hyperthyroidism and in a group of 15 patients with hypothyroidism before and one month after attainment of euthyroidism. in hypothyroid patients, ldl-cholesterol and apo b concentrations decrease significantly after l-t4 repl ... | 1998 | 9623637 |
| preliminary results of bladder preservation by concurrent intraarterial chemotherapy and radiotherapy for muscle-invasive bladder cancer. | we previously reported favorable results of intraarterial doxorubicin chemotherapy in combination with low-dose radiotherapy for locally-advanced bladder cancer. we have now designed a new intraarterial chemotherapy regimen to achieve a higher tumor response rate while preserving a functional bladder. | 1998 | 9624552 |
| neuropsychological impairment and altered thyroid hormone levels in epilepsy. | neuropsychological impairment is a common problem in epilepsy which interferes with the quality of life of patients. similarly, thyroid hormone levels have been observed to be abnormal in patients with epilepsy on various treatments. this study aimed to ascertain any possible correlation between neuropsychological performance and thyroid hormone levels among epilepsy patients. | 1998 | 9624864 |
| occult papillary thyroid carcinoma in hashimoto's thyroiditis presenting as a metastatic bone tumor. | some occult thyroid carcinomas are hypothesized to regress and be eventually obliterated. we report here a patient whose condition supports this hypothesis. a 51-year-old male with primary hypothyroidism due to hashimoto's thyroiditis suffered from a rib bone tumor. he had a diffuse goiter with no nodular lesion. serum ft4 and tsh concentrations were 0.8 ng/dl and 36.4 microu/ml on taking 100 microg/day of t4. anti-tg- and -tpo-ab were strongly positive (99 and 1380 u/ml). the iodine 123 scintig ... | 1998 | 9625454 |
| 99tc(m)-mibi scanning of the thyroid gland in patients with markedly decreased pertechnetate uptake. | diffusely reduced 99tc(m)-pertechnetate uptake is a relatively infrequent but annoying finding that impairs evaluation of the thyroid gland. we studied 32 female patients aged 19-85 years with markedly reduced pertechnetate uptake. the following causes of reduced pertechnetate uptake were recognized: treatment with iodinated pharmaceuticals (n = 15), suppression therapy with t4 (n = 11), subacute thyroiditis (n = 5) and massive tumour replacement (n = 1). 99tc(m)-mibi thyroid scintigraphy was pe ... | 1998 | 9625501 |
| quantitation of amyloid beta-protein (a beta) in the cortex during aging and in alzheimer's disease. | in this study we sought to learn about when and how amyloid beta-protein (a beta) accumulates in the cortex of normal individuals and about the difference in the a beta accumulation between normal aged and alzheimer's disease (ad) brains. from consecutive autopsy cases and ad cases, hippocampus ca1 and occipitotemporal cortex t4 were sampled for a beta quantitation by the well characterized two-site enzyme immunoassays (eias). there was a strong tendency toward a beta 42 accumulation between the ... | 1998 | 9626067 |
| intense sympathetic nerve activity in adults with hypopituitarism and untreated growth hormone deficiency. | perturbations in the sympathetic nervous system may be anticipated in adults with hypopituitarism and untreated gh deficiency, because the syndrome is associated with both peripheral and central factors known to modulate sympathetic traffic. the higher prevalence of hypertension and increased cardiovascular morbidity/mortality reported in gh-deficient patients may suggest increased activity of the sympathetic nervous system. we recorded muscle sympathetic nerve activity (msna) in 10 hypopituitar ... | 1998 | 9626113 |
| fractionated high-dose-rate brachytherapy in primary carcinoma of the nasopharynx. | a growing body of data suggests that local control in nasopharyngeal cancer (npc) is related to the radiation dose administered. we conducted a single-institution study of high-dose radiotherapy (rt), which incorporated high-dose-rate (hdr) brachytherapy (bt). these results were analyzed together with data obtained from controls who did not receive bt. | 1998 | 9626223 |
| thyroxine-induced production of superoxide anion by human alveolar neutrophils and macrophages: a possible mechanism for the exacerbation of bronchial asthma with the development of hyperthyroidism. | bronchial asthma worsens after the development of hyperthyroidism. however, the biochemical mechanism of this phenomenon, which is induced by thyroxine (t4), remains obscure. in the present study, we showed that t4 directly stimulates production of superoxide anion by alveolar neutrophils and macrophages. these cells, when sensitized with a patient's serum and then treated with both the patient's specific allergen and t4, produced higher amounts of superoxide anion than did sensitized cells trea ... | 1998 | 9627810 |
| phage t4 dna [n6-adenine] methyltransferase: kinetic studies using oligonucleotides containing native or modified recognition sites. | the dna-[n6-adenine] methyltransferase of t4 phage (t4 dam mtase) catalyzes methyl group transfer from s-adenosyl-l-methionine (adomet) to the n6-position of adenine in the palindromic sequence, gatc. we have investigated the effect of eliminating different structural components of the recognition site on the ability of a substrate to be bound and methylated by t4 dam. for this purpose, steady state binding (by gel shift assays) and kinetic parameters of methylation (using the methyl donor, [3h- ... | 1998 | 9628341 |
| time-course of interleukin-2 receptor expression in interferon beta-treated multiple sclerosis patients. | the time-course of cd25 (the 55-kd/alpha subunit of the interleukin-2 (il-2) receptor) expression on cd4+ t lymphocytes, and serum levels of soluble il-2 receptors (sil-2r) and il-2 were evaluated in relapsing-remitting multiple sclerosis (rrms) patients treated with interferon beta-1b (ifnbeta1b). peripheral blood samples were collected before therapy (t0), and 1 (t1), 2 (t2), 3 (t3), 6 (t4), and 12 (t5) months after therapy initiation. while at t1 and t2, half the patients showed an increased ... | 1998 | 9628465 |
| chemical and enzymatic properties of bridging 5'-s-phosphorothioester linkages in dna. | we describe physicochemical and enzymatic properties of 5' bridging phosphorothioester linkages at specific sites in dna oligonucleotides. the susceptibility to hydrolysis at various ph values is examined and no measurable hydrolysis is observed at ph 5-9 after 4 days at 25 degrees c. the abilities of three 3'- and 5'-exonuclease enzymes to hydrolyze the dna past this linkage are examined and it is found that the linkage causes significant pauses at the sulfur linkage for t4 dna polymerase and c ... | 1998 | 9628913 |
| [iatrogenic hyperthyroidism secondary to weight loss medication. predictive factors for their precocious detention]. | to establish the differential clinical characteristics between the iatrogenic hyperthyroidism for not conventional medication for obesity treatment (weight losers) and the endogenous by graves basedow disease. | 1998 | 9629770 |
| iodine status, thyroid function and pregnancy: study of swedish and sudanese women. | to examine and compare the effects of pregnancy on the thyroid hormone homeostasis in two different populations with variable iodine supply. | 1998 | 9630385 |
| tnm classification and breast cancer in an african population: a descriptive study. | to determine the stage of female breast cancer in an african population at presentation by using the tnm classification of the international union contra cancer (uicc). | 1997 | 9631114 |
| dna strand exchange proteins: a biochemical and physical comparison. | homologous genetic recombination is an essential biological process that involves the pairing and exchange of dna between two homologous chromosomes or dna molecules. it is of fundamental importance to the preservation of genomic integrity, the production of genetic diversity, and the proper segregation of chromosomes. in escherichia coli, the reca protein is essential to recombination, and biochemical analysis demonstrates that it is responsible for the crucial steps of homologous pairing and d ... | 1998 | 9632377 |
| expressed protein ligation, a novel method for studying protein-protein interactions in transcription. | expressed protein ligation is a novel protein semi-synthesis method that permits the in vitro ligation of a chemically synthesized c-terminal segment of a protein to a recombinant n-terminal segment fused through its c terminus to an intein protein splicing element. in principle, the practical convenience of this method, combined with the expanded opportunities in protein engineering that it provides, makes it well suited for probing the molecular basis of complex processes such as transcription ... | 1998 | 9632677 |
| 3,5,3'-triiodothyronine induces mitochondrial permeability transition mediated by reactive oxygen species and membrane protein thiol oxidation. | ca(2+)-loaded rat liver mitochondria treated with 3,5,3'-triiodothyronine (t3) undergo nonspecific inner membrane permeabilization, as evidenced by mitochondrial swelling, a decrease in membrane potential (delta psi), and an increase in the rate of oxygen uptake. t3 analogues thyroxine (t4), 3',5'-diiodothyronine (t2), and 3,5',3'-triiodothyronine (reverse t3), in decreasing order of potency, resulted in a similar but less extensive effect. permeabilization induced by t3 is dependent on ca2+ (1 ... | 1998 | 9633610 |
| effects of iodotyrosines, thyronines, iodothyroacetic acids and thyromimetic analogues on in vitro copper-induced oxidation of low-density lipoproteins. | we studied the effect of different thyroid compounds [(i2, monoiodo-l-tyrosine (mit), diiodo-l-tyrosine (dit), l-thyronine (t0), 3,5-diiodo-l-thyronine (t2), 3,5,3'-triiodo-l-thyronine (t3), 3,3',5'-triiodo-l-thyronine (rt3), 3,5,3',5'-tetraiodo-l-thyronine (t4), 3,5-diiodothyroacetic acid (ta2), 3,5,3'-triiodothyroacetic acid (ta3) and 3,5,3',5'-tetraiodothyroacetic acid (ta4)] or thyromimetics [(3,5-dimethyl-3'-isopropyl-l-thyronine (dimit) and 3,5-diiodo-3'-isopropyl-thyroacetic acid (ipta2)] ... | 1998 | 9633995 |
| starvation induced hypothyroidism involves perturbations in thyroid superoxide-sod system in pigeons. | this study investigated the influence of starvation over seven days on avian thyroidal superoxide radical levels and superoxide dismutase activity profiles in the indian rock pigeon columba livia intermeida, in relation with iodine metabolism. the serum thyroid hormone profile was assayed to correlate the thyroidal redox status with the circulating thyroid hormone levels. the spin-trapping results suggest a role for thyroidal superoxide anion (o2.-) in causing a hypothyroid state in pigeons duri ... | 1998 | 9635131 |
| carcinoma of the urethra in women. | this analysis was performed to evaluate the influence of clinical and treatment factors on local tumor control, survival, and complications for women with urethral carcinoma. | 1998 | 9635699 |
| acute treatment-related diarrhea during postoperative adjuvant therapy for high-risk rectal carcinoma. | the combination of pelvic radiotherapy and 5-fluorouracil-based chemotherapy is associated with an increase in acute gastrointestinal toxicity during rectal adjuvant therapy, most notably an increased incidence of diarrhea. previous randomized, prospective studies have limited their analysis to presenting rates of severe and life-threatening diarrhea (grade 3 or greater), and few data are available detailing the extent of mild to moderate diarrhea. to provide baseline data for future studies, we ... | 1998 | 9635707 |
| inhibition of escherichia coli rna polymerase by bacteriophage t4 asia. | the 10 kda bacteriophage t4 antisigma protein asia binds the escherichia coli rna polymerase promoter specificity subunit, sigma 70, with high affinity and inhibits its transcription activity. asia binds to sigma 70 primarily through an interaction with sigma 70 conserved region 4.2, which has also been implicated in sequence-specific recognition of the -35 consensus promoter element. here we show that asia forms a stable ternary complex with core rna polymerase (rnap) and sigma 70 and thus does ... | 1998 | 9636696 |
| a human cadaver model for determination of pathologic fracture threshold resulting from tumorous destruction of the vertebral body. | thoracic vertebrae were subjected to compressive loads after drilling of the centrum to simulate destruction from metastatic tumorous involvement. | 1998 | 9636973 |
| changes in cadaveric cancellous vertebral bone strength in relation to time. a biomechanical investigation. | a biomechanical study was conducted during a 3.5-day period to test for changes occurring in pullout strengths of cancellous screws inserted into human cadaveric vertebral bodies. | 1998 | 9636974 |
| altered uv resistance and uv mutational spectrum in repair-proficient murine fibroblasts expressing endonuclease v. | in previously reported studies, we transfected repair-proficient murine fibroblasts with the denv gene of bacteriophage t4 and showed that expression of encoded endonuclease v markedly enhanced cyclobutane pyrimidine dimer (cpd) repair and reduced the frequency of ultraviolet radiation (uv)-induced mutations. in the present studies, we compared the spectra of uv-induced mutations at the hprt locus in denv-transfected and control cells. a significant difference in mutation types was observed. whi ... | 1998 | 9637244 |
| the trophic action of il-7 on pro-t cells: inhibition of apoptosis of pro-t1, -t2, and -t3 cells correlates with bcl-2 and bax levels and is independent of fas and p53 pathways. | signals from the il-7r are essential for normal thymocyte development. we isolated thymocytes from early developmental stages and observed that suspensions of pro-t1, -t2, and -t3 cells rapidly died in culture. addition of il-7 promoted their survival, but did not induce cell division. pro-t4 cells did not undergo rapid cell death, and their survival was therefore independent of il-7. death in the absence of il-7 showed the hallmarks of apoptosis, including dna fragmentation and annexin v bindin ... | 1998 | 9637482 |
| thoracic disc herniations: transthoracic, lateral, or posterolateral approach? a review. | the choice between transthoracic, lateral, and posterolateral approaches to excise thoracic disc herniations remains controversial. | 1998 | 9637619 |
| hiv-related non-hodgkin's lymphoma: chop induction therapy and interferon-alpha-2b/zidovudine maintenance therapy. | in a prospective multicenter study 68 out of 158 patients with hiv infection and malignant lymphoma were assigned to a risk-adapted induction therapy using the following algorithm: high-risk patients fulfilled 2 of 3 criteria: t4 lymphocytes <50/microl; who activity index 3 or 4; pre-existing aids-defining opportunistic infection. normal-risk patients received 4 to 6 cycles of chop chemotherapy; those that achieved complete remission (cr) received zidovudine (500 mg/d) and interferon-alpha maint ... | 1998 | 9638980 |
| [bi-pedical and bi-muscle flap reconstruction of the laryngeal function]. | the method of reconstruction of laryngeal function by bi-pedical and bi-muscle flap (dp-dmf) was presented. the dp-dmf was obtained from sternohyoid muscle, sternothyroid muscle and thyrohyoid muscle. it had enough length, width and plasticity, applicable to all patients with t3 and t4 laryngeal carcinoma. up to now, 102 patients were treated by expanded horizontal hemilaryngectomy and repaired with unilateral or bilateral dp-dmf. after operation, the swallow function returned to normal in 7 to ... | 1996 | 9639721 |
| cardiac troponin i as an early marker of myocardial damage after coronary bypass surgery. | to evaluate the performance of cardiac specific markers, cardiac troponin i (ctni) and ck-mb by mass assay (ck-mb mass), for the early diagnosis of myocardial ischemia and/or infarction after coronary bypass surgery. | 1998 | 9641335 |
| long-term results of 630 thoracoscopic sympathicotomies for primary hyperhidrosis: the vienna experience. | to evaluate of the results of thoracoscopic sympathicotomy for upper limb hyperhidrosis with a median observation period of more than 15 years. | 1998 | 9641386 |
| non-nearest neighbor effects on the thermodynamics of unfolding of a model mrna pseudoknot. | the upstream autoregulatory mrna leader sequence of gene 32 of 17 t-even and related bacteriophages folds into a simple tertiary structural motif, a hairpin-type rna pseudoknot. in phage t4, the pseudoknot is contained within 28 contiguous nucleotides which adopt a pseudocontinuous helical structure derived from two coaxially stacked helical stems of four (stem 1) and seven (stem 2) base-pairs connected by two inequivalent single-stranded loops of five and one nucleotide(s). these two loops cros ... | 1998 | 9641977 |
| mutational analysis of phi29 dna polymerase residues acting as ssdna ligands for 3'-5' exonucleolysis. | here, three highly conserved amino acid residues have been characterized to function as ssdna binding ligands at the 3'-5' exonuclease active site of phi29 dna polymerase. one of these residues, phe65, belongs to motif exo ii, previously described to contain an invariant aspartate and an invariant asparagine involved in catalysis and ssdna binding, respectively. the other two residues, ser122 and leu123, form a newly identified motif "(s/t)lx2h", and are the homologous counterparts of pol i resi ... | 1998 | 9642062 |
| thyroid gland and epididymal sperm motility in rats. | the purpose of this research was to investigate the effect of hypofunction of the thyroid gland, caused by radioactive suppression of the gland, on the pattern of spermatozoa motility in different segments of the rat epididymis. thyroidectomy was obtained by i.p. infection of 270 microci of i-131. after about 30 days, the animal reached hypothyroidism as determined by serum level of t4. when the motility pattern of the sperm obtained from the epididymis of normal rats was compared to that of hyp ... | 1998 | 9642456 |
| the association of congenital hypothyroidism and congenital gastrointestinal anomalies in down's syndrome infants. | to study the prevalence of congenital hypothyroidism in infants with down's syndrome and to verify whether there is an association with other congenital defects. | 1998 | 9642639 |
| [a case of primary squamous cell lung cancer invading the wall of the distal aortic arch and the left subclavian artery: successful surgical management using ecc with selective cerebral perfusion]. | a 37-year-old male was referred to our hospital with symptoms suggesting pneumonia. the preoperative diagnosis was primary lung cancer of the left upper lobe invading the distal aortic arch (daa) (t4, stage iiib). complete resection was performed with associated resection of the pneumonectomy, daa, and left subclavian artery. dacron graft replacement was performed using ecc with selective cerebral perfusion. histological examination revealed squamous cell carcinoma, n1 and negative surgical marg ... | 1998 | 9642697 |
| a randomised comparison of 'casodex' (bicalutamide) 150 mg monotherapy versus castration in the treatment of metastatic and locally advanced prostate cancer. | to evaluate the efficacy and tolerability of 'casodex' monotherapy (150 mg daily) for metastatic and locally advanced prostate cancer. | 1998 | 9643663 |
| uv-dna damage in mouse and human cells induces the expression of tumor necrosis factor alpha. | ultraviolet light induces the expression of tumor necrosis factor alpha (tnf alpha) in many mammalian cells. we have examined the signal for this induction in a human dna repair-deficient cell line carrying a transgene composed of the murine tnf regulatory sequences fused to the chloramphenicol acetyltransferase (cat) structural gene. when compared by fluence, uvc was a more efficient inducer of cat than was uvb, but they were equivalent inducers when compared by the frequency of cyclobutyl pyri ... | 1998 | 9644008 |
| [predictive significance of reflex otalgia in local radical radiotherapy of oropharyngeal carcinomas]. | patients with carcinomas of the upper aero-digestive tract often suffer from ear pain as a tumor associated syndrome. this prospective study examines the predictive and prognostic value of this symptom. | 1998 | 9645211 |
| characterization of gene-specific dna repair by primary cultures of rat hepatocytes. | at present, almost all the information on gene-specific dna repair in mammals comes from studies with transformed cell lines and proliferating primary cells obtained from rodents and humans. in the present study, we measured the repair of specific dna regions in primary cultures of nondividing rat hepatocytes (parenchymal cells). dna damage was induced by irradiating the primary cultures of hepatocytes with ultraviolet (uv) light, and the presence of cyclobutane pyrimidine dimers (cpds) was meas ... | 1998 | 9648918 |
| multigenerational study of the effects of consumption of pcb-contaminated carp from saginaw bay, lake huron, on mink. 1. effects on mink reproduction, kit growth and survival, and selected biological parameters. | this study was conducted to determine the multigenerational effects of consumption of pcb-contaminated carp (cyprinus carpio) from saginaw bay (lake huron) on mink (mustela vison) reproduction and health and to examine selected biomarkers as potential indicators of polyhalogenated hydrocarbon toxicity in mink. the mink were fed diets formulated to provide 0 (control), 0.25, 0.5, or 1.0 ppm polychlorinated biphenyls (pcbs) through substitution of saginaw bay carp for ocean fish in the diets. to d ... | 1998 | 9650571 |
| safety of beating heart anastomosis during video-assisted coronary surgery attested by cardiac troponin i. | our objective was to evaluate the safety of coronary anastomosis on the beating heart by measuring the release of cardiac troponin i during minimally invasive coronary artery bypass grafting (micabg). cardiac troponin i (ctni) is a reliable marker of cardiac ischemia during heart operations under cardiopulmonary bypass (cpb). ten patients (8 males and 2 females, aged 41-63) underwent micabg with single vessel bypass grafting for left anterior descending coronary artery (lad) stenosis (n = 7) or ... | 1998 | 9650674 |
| prostate-thyroid axis: stimulatory effects of ventral prostate secretions on thyroid function. | endocrine cells of the prostate secrete thyrotropin (tsh)-releasing hormone (trh), trh- and tsh-like peptides, and growth factors. propylthiouracil- and methimazole-induced hypothyroidism increased prostatic levels of trh in rats as in hypothalamus, whereas thyroxine (t4) replacement decreased trh. from these reports, we inferred the existence of a prostate-thyroid axis. | 1998 | 9650910 |
| relation between bone mineral content and clinical, hormonal and biochemical parameters in postmenopausal women. | we studied factors related to bone mass after a natural or surgical menopause in 73 healthy women attending the menopause clinic of a university hospital. in the natural menopause group we found inverse correlations between bone mineral density (bmd) vs. menopausal duration; bmd vs. body mass index (bmi) and bmi vs. inorganic phosphate (pi), borderline correlations between weight vs. thyroxin (t4) and weight vs. luteinising hormone (lh) and a positive correlation between androstenedione (d4a) vs ... | 1998 | 9651656 |
| disposition of 2-methylimidazole in rats. | 2-methylimidazole (2-mi), widely used as a chemical intermediate, is also present in cigarette smoke and may form in food and forage as a result of ammoniation of simple sugars. 2-mi has been shown to be neurotoxic in several animal species and to alter serum levels of t3, t4, and thyroid-stimulating hormone (tsh) in the rat, apparently leading to hyperplasia of thyroid follicular cells. in order to better characterize 2-mi-induced toxicity, the disposition of [2-(14)c]-2-mi has been investigate ... | 1998 | 9652548 |
| induction chemotherapy and radiotherapy in loco-regionally advanced epidermoid carcinoma of the anal canal. | to evaluate the efficacy of induction chemotherapy in combination with radiotherapy for treatment of loco-regionally advanced epidermoid anal carcinoma. | 1998 | 9652850 |
| a hypopituitary patient who attained tall stature without growth hormone. | we describe an unusual patient with hypopituitarism who attained tall stature even without growth hormone (gh). a 37-year-old man was devoid of secondary sexual characteristics, but manifested tall stature with a eunuchoidal feature. serum levels of gh, insulin-like growth factor-i, gonadotropins and testosterone were all below normal. gh secretion was not enhanced by any provocative stimulus. adrenocorticotropic hormone increased after administration of corticotropin releasing hormone, but not ... | 1998 | 9652904 |