Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| potential usefulness of the chimaeric type 1/type 2 poliovirus, v510 in universal reduction of poliomyelitis morbidity. | 2007 | 3214600 | |
| antibody response of children to measles vaccine mixed with diphtheria-pertussis-tetanus or diphtheria-pertussis-tetanus-poliomyelitis vaccine. | the feasibility of giving measles vaccine mixed with either diphtheria-pertussis-tetanus (dpt) or dpt-poliomyelitis (dptp) vaccine was investigated to simplify the routine immunization schedule. children 12 to 18 months of age, due for measles immunization, were given measles vaccine alone or mixed with dpt or dptp. their prevaccination and four-weeks postvaccination serum samples were tested for the measles virus hemagglutination-inhibition antibody titer. although 191 children completed the st ... | 1988 | 3257842 |
| simultaneous administration of haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine with routine diphtheria-tetanus-pertussis and inactivated poliovirus vaccinations of childhood. | a haemophilus influenzae type b capsular polysaccharide-diphtheria toxoid conjugate vaccine (prp-d) is capable of protecting infants against invasive h. influenzae diseases. therefore it is very likely that it will be incorporated in routine vaccination schedules during the next few years. in order to test the suitability of simultaneous administration of prp-d and other vaccines we administered it to 25 infants mixed with diphtheria-tetanus-pertussis vaccine at 3, 4 and 6 months and simultaneou ... | 1988 | 3261414 |
| safety of oral poliomyelitis vaccine: results of a who enquiry. | the date received from the 13 countries participating in the world health organization (who) collaborative study to obtain information on the possible risks associated with the use of oral poliomyelitis vaccine (opv) and on measures to reduce these risks if they were shown to exist are reported for 1980-84. the data largely confirm earlier patterns and particularly those for 1975-79. 4 countries with a total population of 39 million were free from cases of acute persistent spinal paralysis (ap ... | 1988 | 3266113 |
| live or inactivated poliomyelitis vaccine: an analysis of benefits and risks. | using decision analysis we evaluated the benefits and risks of continued primary reliance on oral poliomyelitis vaccine (opv) compared to use of inactivated poliovirus vaccine (ipv). we followed a hypothetical cohort of 3.5 million children from birth to age 30 assuming 95 per cent coverage with 98 per cent effective vaccine. primary reliance on ipv would result in more cases of paralytic poliomyelitis as well as more susceptibles remaining in the population than would be expected with continuin ... | 1988 | 3277452 |
| polio immunization policy in the united states: a new challenge for a new generation. | the primary reason that live poliovirus vaccine is recommended in the united states today is because it may immunize contacts who have not otherwise chosen to be vaccinated. this policy places contacts at risk of paralysis from an untested, unlicensed "spread virus" vaccine and places infants at risk for an unproven, theoretical benefit to others, not themselves. the licensed killed poliovirus vaccine provides equivalent protection to those vaccinated, with no risk to recipients or contacts. the ... | 1988 | 3277453 |
| rationale for the sequential use of inactivated poliovirus vaccine and live attenuated poliovirus vaccine for routine poliomyelitis immunization in the united states. | despite the concerns mentioned in the last section, there are many reasons to believe that a polio immunization schedule that incorporates sequential doses of inactivated poliovirus vaccine and live attenuated poliovirus vaccine would provide both humoral and intestinal immunity to the fully immunized person that is at least as good, if not better, than the immunity achieved by the use of ipv or opv alone. a substantial degree of protection should also extend to partially immunized and unimmuniz ... | 2012 | 3320922 |
| sabin and salk poliovirus vaccine: vice versa. | 1987 | 3329800 | |
| from jenner to genes--the next generation of virus vaccines. | vaccination has played a major role in the control of many virus diseases affecting man and animals. two kinds of vaccines are in use: (i) attenuated vaccines, which infect the host without causing disease and (ii) killed vaccines, which consist of large amounts of virus particles that have been inactivated by either physical or chemical agents under conditions that ensure retention of their antigenic properties. despite the success of vaccination there is still a need for products that are safe ... | 1987 | 3332769 |
| simultaneous administration of measles-mumps-rubella vaccine with booster doses of diphtheria-tetanus-pertussis and poliovirus vaccines. | the safety and efficacy of simultaneous administration of measles-mumps-rubella (mmr), diphtheria-tetanus-pertussis (dtp), and trivalent oral poliovirus (opv) vaccines in a test group of 405 children were compared with the safety and efficacy of sequential administration of the same vaccines in a control group of 410 children given mmr followed by booster doses of dtp and opv 2 months later. the study was double blind and placebo controlled with respect to dtp and opv. seroconversion rates to me ... | 1988 | 3340474 |
| stability of oral polio vaccine at different temperatures. | the stability of five batches of oral polio vaccine stored at -20, 4-8, 22 and 36 degrees c for 7, 14 and 21 days was studied. the virus titrations were performed by the standard macro-method. there was little loss in virus titre when samples were kept at -20 and 4-8 degrees c for 21 days, whereas the samples exposed to 36 degrees c for 21 days showed almost complete loss in virus titre. the average loss in virus titre in a year (log tcid50) was 0.47 at -20 degrees c and 0.65 at 4-8 degrees c wh ... | 1988 | 3354252 |
| development and application of rna probes for the study of picornaviruses. | single-stranded rna probes were developed from cloned cdna fragments derived from four picornaviruses; poliovirus type 1, coxsackievirus b3, echovirus 9 and theiler's murine encephalomyelitis virus. in comparative testing with a nick-translated cdna probe, the rna probe was found to be 10-100-fold more sensitive. hybridization conditions were optimized for rna probes to picornavirus targets. longer hybridization times gave an improved signal, as did a temperature of 50 degrees c. formamide conce ... | 1988 | 3380106 |
| live virus vaccines in human immunodeficiency virus-infected children: a retrospective survey. | live virus vaccines can cause serious adverse reactions when administered to immunocompromised patients. because children infected with human immunodeficiency virus (hiv) may be immunosuppressed, immunization of these children with live virus vaccines is a potential problem. a retrospective survey was conducted by the new york city department of health, with consultation from the centers for disease control, to evaluate the frequency of serious adverse events following receipt of live vaccines a ... | 1988 | 3399296 |
| continuing global poliomyelitis morbidity and lacunae of trivalent poliovirus vaccines. | 1988 | 3420972 | |
| progress toward wild poliovirus eradication in el salvador, guatemala, and honduras. | 1987 | 3440181 | |
| association between fever and the antibody response to tamm-horsfall protein in urinary tract infection. | the usefulness of measuring serum antibodies to tamm-horsfall protein (thp) for diagnosing the level of acute urinary tract infections in adult women was evaluated. there was a significant (p less than 0.001) elevation of igg and iga anti-thp in pregnant and non-pregnant women with acute pyelonephritis compared to women with acute cystitis. the changes in anti-thp antibody titre among patients with acute pyelonephritis varied considerably, limiting the value of determining such antibodies for di ... | 1987 | 3445127 |
| clinical improvement of two patients with t lymphotropic retrovirus diseases after polio vaccine hyperimmunization. | patients with acute leukemia have an impaired ability to produce antibodies to poliovirus in response to inoculation with inactivated vaccine. reimmunization will, however, produce a relative increase in antibodies equivalent to that of healthy subjects. a child with acute lymphocytic leukemia was hyperimmunized with salk polio vaccine following a relapse and has had no further relapse nor sequelae for 20 years. an adult physician with acquired immunodeficiency syndrome hyperimmunized himself wi ... | 1987 | 3471369 |
| secretory antibodies in iga-deficient and immunosuppressed individuals. | total levels of igm and secretory igm as well as specific antibodies to poliovirus type i antigen, escherichia coli o antigens, and beta-lactoglobulin were measured in unstimulated and stimulated saliva as well as nasal secretion using an enzyme-linked immunosorbent assay (elisa). the levels of these antibodies in iga-deficient adults with and without frequent respiratory infections and children under immunosuppressive therapy for malignant disease were compared to those in normal adults and inf ... | 1986 | 3489000 |
| immunization of neonates with trivalent oral poliomyelitis vaccine (sabin). | a study was carried out between november 1981 and april 1982 on the immunological effect of administering trivalent live, oral polio vaccine to 200 mature healthy neonates from henan province, china. the initial dose of vaccine was given at 3 days of age, and 2 months thereafter antibodies to poliovirus types 1, 2, and 3, respectively, were detected in 46.7%, 60.7% and 48.6% of the neonates; after the second dose, the levels were 86.9%, 95.3%, and 97.2%, with geometric mean titres of 1:106.2, 1: ... | 1986 | 3493854 |
| analysis of the antigen- and mitogen-induced differentiation of b lymphocytes from asymptomatic human immunodeficiency virus-seropositive male homosexuals. discrepancy between t cell-dependent and t cell-independent activation. | five asymptomatic human immunodeficiency virus (hiv)-seropositive male homosexuals were immunized with the recall antigens tetanus toxoid (tt) and the three types of poliovirus present in diphtheria, tetanus, and polio vaccine. four weeks after immunization, the in vivo response to booster immunization, the in vitro pokeweed mitogen (pwm)-induced igg secretion, and the in vitro t cell-dependent and t cell-independent antigen-induced antibody response were assayed. increase in serum antibody tite ... | 1987 | 3499462 |
| oral poliovirus vaccine in tropical africa: greater impact on incidence of paralytic disease than expected from coverage surveys and seroconversion rates. | during the first 5 years of a poliomyelitis control programme in yaounde, cameroon, a maximum of 35% of children aged 12-23 months were estimated to have received three doses of trivalent oral vaccine. despite this low immunization coverage and low seroconversion rates, which were determined concurrently, the estimated incidence of paralytic poliomyelitis decreased by 85%.a detailed study of immunized children and of children living in the same households suggests that community spread of the va ... | 1987 | 3500802 |
| molecular cloning and sequence determination of the genomic regions encoding protease and genome-linked protein of three picornaviruses. | to investigate the degree of similarity between picornavirus proteases, we cloned the genomic cdnas of an enterovirus, echovirus 9 (strain barty), and two rhinoviruses, serotypes 1a and 14lp, and determined the nucleotide sequence of the region which, by analogy to poliovirus, encodes the protease. the nucleotide sequence of the region encoding the genome-linked protein vpg, immediately adjacent to the protease, was also determined. comparison of nucleotide and deduced amino acid sequences with ... | 1986 | 3512851 |
| demonstration of calicivirus in human faeces by immunosorbent and immunogold-labelling electron microscopy methods. | immunosorbent electron microscopy (isem) and immuno-gold staining (igs) electron microscopy methods have been applied to human faeces, shown by direct electron microscopy (em) to contain calicivirus. caliciviruses were successfully trapped on grids coated with positive rabbit or human antisera against calicivirus, but not with negative sera. caliciviruses were specifically labelled with gold particles, when treated with positive rabbit or human antisera against calicivirus followed by protein a- ... | 1986 | 3539960 |
| injections and poliomyelitis: what are the risks of vaccine associated paralysis? | provocation by injections can increase the risk of paralytic poliomyelitis by up to 25 fold. in england and wales the risk of provocation paralysis from dpt given with oral poliovirus is 1 to 2 cases per million children immunized. cases in india following immunization with oral poliovaccine and dpt are likely to be caused by wild rather than vaccine virus. most cases of poliomyelitis in the third world probably follow provocation by unsterile and unnecessary injections. there should normally be ... | 1986 | 3549394 |
| picornaviral processing: some new ideas. | mature picornaviral proteins are derived by progressive, post-translational cleavage of a giant precursor polyprotein. at least three viral-encoded proteolytic activities are involved in the processing. the first cleavage takes place while the polyprotein is still nascent on a ribosome. in poliovirus, this event is probably catalyzed by peptide 2a, a protein from the middle portion of the genome. most subsequent processing is effected by viral protease 3c, a thiol-type enzyme, responsible for ei ... | 2013 | 3553216 |
| combined live and inactivated poliovirus vaccine to control poliomyelitis in a developing country--five years after. | the gaza strip is an area in transition which in the 1960's had a high prevalence of malnutrition and infectious diseases. the infant mortality was approximatively 140 per 1000 live births. pediatric services were almost non-existant. trivalent oral poliovaccine (topv) has been used since 1967. coverage however did not exceed 70%. from 1973 a network of comprehensive child health centers was spread throughout the area, a set of laws was passed which made vaccination obligatory and the community ... | 1986 | 3556771 |
| paralytic poliomyelitis in italy (1981-85). | fifteen cases of presumptive poliomyelitis occurring in italy between 1981-85 were studied in order to differentiate between paralysis caused by poliovirus and that of different etiology. out of seven confirmed cases three were "temporally associated with vaccination". three aspects are discussed: the need for a careful differential diagnosis of paralytic cases; the over concern about the problem of vaccine-associated cases: the risk connected with re-importation of wild poliovirus strains. | 1987 | 3582600 |
| paralytic poliomyelitis in england & wales, 1970-84. | in 1962 the public health laboratory service (phls) became responsible for the poliomyelitis surveillance scheme for england and wales, which since 1970 has included the world health organisation (who) enquiry into acute persisting spinal paralysis. all the records have been kept, including those of patients who were later considered not to have had poliomyelitis. this paper reviews the cases between 1970-84 of patients normally resident in england and wales, where the clinical features of the i ... | 1987 | 3609178 |
| proportions of immunoglobulin isotypes in paralytic poliomyelitis and after vaccination. | immunoglobulin isotype composition of poliovirus antibodies was studied by isotype-specific solid-phase radio-immunoassay (ria) in four patients with paralytic poliomyelitis, five adults receiving live poliovirus vaccine as a booster immunization, and seven children receiving first doses of inactivated poliovirus vaccine. in paralytic poliomyelitis serum and cerebrospinal fluid (csf) poliovirus antibodies were mainly of igg1, igg3, and iga isotypes. igm antibodies were found in sera but not in c ... | 1987 | 3611298 |
| susceptibility of aedes albopictus c6/36 cells to viral infection. | the susceptibility of the c6/36 clone of aedes albopictus monolayer cell cultures was determined with 46 prototype viruses passed through three subcultures. viral growth was confirmed by titration of the passage material in other susceptible host systems. nineteen viruses demonstrated good growth in c6/36 cells: coxsackievirus group a type 10 and group b types 2, 3, 4, and 5; enterovirus 69; mumps virus; poliovirus types 1 to 3; reovirus types 1 to 3; vaccinia virus; dengue virus type 2; eastern ... | 1987 | 3611315 |
| identification of nuclear cap specific proteins in hela cells. | two polypeptides of apparent molecular mass of 20 and 115 kilodaltons in nuclear fractions from hela cells were shown to recognize and be crosslinked to the cap structure of eukaryotic mrnas in a cap-dependent fashion. crosslinking of the 20 and 115 kda polypeptides was sensitive to inhibition by low concentrations of the cap analogue m7gdp and resistant to inhibition by high kcl concentrations. in addition, crosslinking of these polypeptides to the cap structure occurred in nuclear extracts pre ... | 1987 | 3627995 |
| vaccine-associated poliomyelitis in a household contact with netherton's syndrome receiving long-term steroid therapy. | paralytic poliomyelitis developed in a man 51 days after his two-month-old daughter received her first dose of trivalent live oral poliovirus vaccine. the patient was receiving long-term glucocorticosteroid therapy (tapered to 12.5 mg per day for the eight months prior to his poliomyelitis) for netherton's syndrome, a congenital syndrome characterized by bamboo-like hair, hyperkeratotic and hyperhidrotic skin, and multiple allergies. the patient was ventilator-dependent and quadriplegic througho ... | 1987 | 3674066 |
| vaccine-associated contact paralytic poliomyelitis with atypical neurological presentation. | paralytic poliomyelitis presenting with quadriparesis, transient encephalitis and bulbar symptoms in 2 patients in close contact with recently vaccinated children with trivalent live oral polio vaccine is described. symmetrical lower motor neuron involvement of deltoid muscles with electromyographic confirmation was found. upper motor neuron signs, with symmetrical hyperactive deep tendon reflexes developed in the lower extremities. poliovirus type-2 vaccine-like strain was cultured from one pat ... | 1987 | 3687370 |
| live poliovirus vaccine in patients with chronic glomerulonephritis: effects on renal function and specific antibody response. | twenty-one patients with chronic glomerulonephritis (gn) (5 with renal failure) received three doses of live trivalent poliovirus vaccine administered orally. the effect of the polio vaccination on the renal function and the titers of antibodies to poliovirus were studied. no significant consequence was observed in renal disease. before vaccination, titers of poliovirus type 1 and 3 antibodies were significantly decreased as compared to healthy adult subjects. after vaccination, the patients exh ... | 1987 | 3690900 |
| poliovirus vaccines: live or dead. | 2013 | 3712146 | |
| titration of poliovaccines: improvement of end-point microassays by means of dose-response curves. | the w.h.o.'s titration method for attenuated poliovaccines, using two-fold dilution steps, was assayed concurrently with an alternative method, using four-fold dilution steps. for the two-fold dilution method, the dispersion of the observed proportions of response was very wide, inducing biased estimations for titers and their standard-error by means of simple usual calculation procedures. on the other hand, the use of the four-fold dilution method constantly provides more accurate estimates for ... | 1986 | 3722311 |
| improved inactivated poliovirus vaccine: an update. | 2006 | 3725638 | |
| oral efficacy of win 51711 in mice infected with human poliovirus. | win 51711, a new broad-spectrum anti-picornavirus agent, prevented the development of paralysis and subsequent death in mice infected intracerebrally with a lethal dose of human poliovirus type 2 (mef strain). the prophylactic efficacy of intragastrically administered win 51711 was dose dependent over the 3.9- to 62.5-mg/kg (twice daily) dose range, with a minimal significantly effective dose of less than 15.6 mg/kg per dose (twice daily) (p less than 0.008). an oral four times a day dosage regi ... | 1986 | 3729333 |
| [antiviral action of lysolecithin analogs against human pathogenic viruses]. | the virucidal effect, the inhibition of virus adsorption and penetration and the influence on later phases of replication of human pathogenic viruses were studied. the compounds showed a significant virucidal effect to enveloped viruses (measles virus, herpes virus type 1 and 2), whereas the compounds were ineffective against nonenveloped viruses (coxsackie virus a9 and b1, attenuated poliovirus type 1, adenovirus type 1). interactions with the viral envelope are supposed. | 1986 | 3763682 |
| the effect of primary immunization and concanavalin a on the production of monoclonal natural antibodies. | hybridomas derived from mice sham-immunized with saline were found to secrete 'natural' antibodies with a wide range of specificities. a high response to bovine serum albumin (bsa) and in particular bsa conjugated with oxazolone was observed routinely. the oxazolone-bsa response was probably directed toward antigenic sites exposed as a result of the coupling procedure; only 2% of the oxazolone-bsa-binding supernatants also bound to oxazolone-ovalbumin. an unexpected cross-reactivity was seen bet ... | 1986 | 3770775 |
| fatal disseminated infection due to poliovirus type 2 vaccine. | 1986 | 3776928 | |
| [acute meningoencephalitis caused by type 2 poliovirus during hepatitis a]. | 1986 | 3796191 | |
| "in vitro" study on human mononuclear phagocytic cells behaviour versus dna and rna viruses. | it is generally accepted that mononuclear phagocytic cells are of crucial importance in defence against viral infections. using a method of "in vitro" differentiation from human blood monocytes to macrophages, the interactions between human monocyte-macrophage with herpes simplex virus type 1 and 2, adenovirus type 17, coxsackie virus b type 4, poliovirus type 1 and echo virus type 2, are reported. in all viruses tested on monocytes, the infection of the cells was very poor according to the data ... | 1985 | 3843076 |
| relevance of studies of cellular receptors to the prevention and control of viral disease: memorandum from a who meeting. | this memorandum describes recent scientific advances in the identification and characterization of cell receptors for viruses and their relevance to programmes for the prevention and control of viral diseases. these areas of anti-viral research provide an improved understanding of the mechanisms of viral pathogenesis and a rational basis for the development of anti-viral drugs, viral vaccines, and new diagnostic approaches and reagents. advances in research to characterize the cellular receptors ... | 1985 | 3879672 |
| protective factors in milk and the development of the immune system. | the neonate is immature in certain immunologic functions. the slow development of secretory immunoglobin a (iga) seems to be compensated by selective transfer of secretory igm into exocrine secretions on mucous membranes during the first few months of life. secretory iga and secretory igm antibodies against escherichia coli and poliovirus are already found in the neonate, possibly in response to the maternal anti-idiotypic igg antibodies transplacentally exposing the fetus. via such a mechanism, ... | 1985 | 3880886 |
| local immune responses. | 1985 | 3882186 | |
| vaccines from monoclonal anti-idiotypic antibody: poliovirus infection as a model. | 1985 | 3910363 | |
| the efficacy of dpt and oral poliomyelitis immunization schedules initiated from birth to 12 weeks of age. | infants should receive live trivalent oral poliovirus vaccine (topv) and dpt immunization as early in life as possible in order to minimize the time that they are at risk of contracting these vaccine-preventable diseases. passively acquired circulating maternal antibodies provide protection in the 1st few weeks or months of life. although these antibodies may modify or block the serum immune response during the 1st few weeks of life, the 1st or priming dose of dpt can be given effectively after ... | 1985 | 3914926 |
| entry mechanisms of protein toxins and picornaviruses. | the mode of entry into cells of a number of protein toxins with intracellular sites of action and of three picornaviruses is discussed. of the different toxins in this group, diphtheria toxin has been most thoroughly studied with respect to its uptake mechanism. this toxin binds to cell surface receptors which are possibly part of the major anion-transport system in the cells. the bound toxin is then endocytosed and, when the ph drops below ph 5, a normally hidden hydrophobic domain is exposed a ... | 1985 | 3915869 |
| neonatal paralytic poliomyelitis. a case report. | neonatal poliomyelitis, which was rare even when poliomyelitis was widespread, has not been reported in the united states since use of live oral poliovirus vaccine (sabin's vaccine) became widespread. we report a child who became symptomatic with apnea at 18 days of age and who subsequently developed a permanent monoparesis. serologic and cultural evidence indicated the virus as poliovirus vaccine type. another infant who received live oral poliovirus vaccine was probably the source of the infec ... | 1986 | 3947264 |
| salivary antibody responses to oral and parenteral vaccines in children. | salivary iga antibody to poliovirus and tetanus toxoid was measured in whole salivas of 151 children between 2 and 48 months of age from north america and from scandinavia. children from urban and suburban populations in the greater boston, ma, area receive both oral poliovaccine and a parenteral injection with tetanus toxoid (tt), initially at approximately 2 months of age. children from göteborg, sweden, initially receive parenteral injections of tt at 2 months of age and parenteral injections ... | 1986 | 3958136 |
| control of poliomyelitis in bulgaria: experience of two decades. | 1985 | 3969493 | |
| [flaccid paralysis following oral poliomyelitis vaccination]. | this is the report of a four months old boy who developed a serous meningitis and flaccid paralysis of the left upper and lower extremity 17 days following the first immunisation with a trivalent life poliomyelitis vaccine. the patient recovered well within 2 months. presently a mild functional disturbance and muscle wasting of the left leg can still be observed. an acute poliomyelitis can be due to a wild virus infection in an unimmunized child. secondly an acute poliomyelitis can occur as vacc ... | 1985 | 3975062 |
| the standardization of infectivity titrations of poliovaccines--a who collaborative study. | the reproducibility of a method for infectivity titrations of live poliovaccines using microtitre plates was investigated in a who collaborative study involving eight laboratories. the large variation (up to 100-fold) in estimates of infectivity observed between laboratories using their local methods of assay was reduced to no more than fourfold when a common method was used. however, expressing infectivities relative to those of the monovalent reference viruses improved the agreement between th ... | 1985 | 3997898 |
| virus persistence in groundwater. | more than 50% of the outbreaks of waterborne disease in the united states are due to the consumption of contaminated groundwater. an estimated 65% of the cases in these outbreaks are caused by enteric viruses. little, however, is known about the persistence of viruses in groundwater. the purpose of this study was to determine whether measurable chemical and physical factors correlate with virus survival in groundwater. groundwater samples were obtained from 11 sites throughout the united states. ... | 1985 | 4004211 |
| use of bituminous coal as an alternative technique for field concentration of waterborne viruses. | a filter system that sandwiches a bituminous coal preparation between two prefilters was comparable to those presently used to recover human viruses from large volumes of water. this filter was effective over a ph range of 3.0 to 7.0. poliovirus type 1 recoveries from 100-liter seeded samples of cincinnati tap water did not vary significantly when compared with those of identical samples processed through filterite and millipore filters. in studies with raw domestic sewage, virus recoveries were ... | 1985 | 4004235 |
| [antipoliomyelitis vaccination of young children with a new inactivated vaccine. serological results]. | an inactivated trivalent poliovirus vaccine, prepared on simian line-cells (vero cells), has been injected in 3 doses one month apart in 36 infants, 2 to 11 months old (30 of whom were 2 to 6 months old) to determine its tolerance and antigenic efficacy. each dose contained 40, 8 and 32 antigenic d units for the 3 types respectively. dpt vaccine was injected simultaneously in another part of the body. before beginning the immunization program, 20 infants had significant titers of antibodies agai ... | 1985 | 4004496 |
| [experimental substantiation of using immunomodulators of the phenylimidazothiazole type for the correction of secondary immunologic insufficiency caused by poliomyelitis virus]. | 1985 | 4024598 | |
| ultrastructural changes of motoneurons in monkeys infected with enterovirus 71. brief report. | tissues of the central nervous system (cns) of cynomolgus monkeys were examined by electron microscopy after intraspinal inoculation of enterovirus 71 (e71). a characteristic finding was the appearance of numerous membrane-bound vesicles (mbvs) in affected motoneurons. similar mbvs were also present in e71-infected cynomolgus monkey kidney (cmk) cells in culture. virus-like particles were found within or around mbvs in motoneurons as well as in infected cmk cells in culture. neither mbvs nor e71 ... | 1985 | 4038070 |
| inactivated polio vaccine: industrial production from micro-carrier vero cells culture. | in 1980, we presented our preliminary results of large-scale production of inactivated polio-vaccine (ipv). the virus was produced by vero cells culture grown on micro-carrier in 150 litre tanks; now we produce the poliovirus in 1000 litre tanks. all the tests certifying the 'cell bank' have been passed; the quality of purification procedure was demonstrated; additional clinical studies were done; this new reassessed ipv was licensed in france in july 1982. | 1985 | 4071633 |
| level of antibodies in human gamma-globulin preparations. | 1970 | 4098253 | |
| antibodies in commercial preparations of gamma-globulin. | 1970 | 4098260 | |
| immunoprophylaxis of viral infections in childhood. | 1970 | 4099208 | |
| [interference phenomenon between street rabies virus and poliovirus in tissue cultures]. | 1970 | 4099469 | |
| the mechanism of guanidine inhibition of poliovirus growth in vitro. | 1970 | 4099578 | |
| immunoglobulins level in saliva of children with poliomyelitis and of healthy children after oral vaccination with live attenuated poliovirus strains type 2 and 3. | 1970 | 4101723 | |
| antiviral activity of polyinosinic-polycytidylic acid in the absence of cell-controlled rna synthesis. | 1971 | 4101769 | |
| the size of some mammalian picornaviruses. | 1971 | 4101809 | |
| immunoelectrophoresis of poliovirus antigens. | 1971 | 4103490 | |
| in vitro assembly of poliovirus. ii. evidence for the self-assembly of 14 s particles into empty capsids. | 1971 | 4105254 | |
| biochemical and biophysical properties of vesicular exanthema of swine virus. | 1971 | 4105255 | |
| the structure of heated poliovirus particles. | 1971 | 4105288 | |
| poliovirus antibody response in patients with acute leukemia. | 1971 | 4105452 | |
| poliovirus antibodies in breast-fed infants. | 1971 | 4105976 | |
| late stage synchronization of respiratory syncytial virus replication. | 1971 | 4106351 | |
| isolation of hemorrhagic nephroso-nephritis virus in cell cultures. | 1971 | 4107353 | |
| antigenic characterization of type 3 poliovirus strains isolated (1968-1970) in italy from vaccinated and unvaccinated patients. | 1971 | 4108589 | |
| a2-hong kong influenza virus infection and lipid changes in primary human and other cell types. | 1972 | 4110512 | |
| observations on interactions between fluorescein-iso-thiocyanate conjugates and cells in vitro. | during the course of some routine immunofluorescence studies ;non-specific' staining occurred in the absence of free fluorescein and of any known impurities. the cause of such staining seems to be associated with phasic changes occurring at varying population doublings (;passages') in species-homologous cells subjected to serial cultivation. | 1972 | 4114699 |
| stimulation of restricted reproduction of emc virus in hela cells by non-replicating poliovirus. | 1973 | 4119353 | |
| inhibition of poliovirus rna, synthesis in an in vitro system by antiserum against 14s virus-specific structures. | 1973 | 4120844 | |
| ultrastructural study of viral replication in human fetal intestinal organ culture. | 1973 | 4121665 | |
| virus replication, cytopathology, and lysosomal enzyme response of mitotic and interphase hep-2 cells infected with poliovirus. | mitotic hep-2 cells, selected by the pel (colloidal silica) density gradient method and held in mitosis with colcemid, are readily infected by poliovirus type i (mahoney). they produce and release the same amount of virus as interphase, random-growing cells. in contrast to interphase cells, mitotic cells show no detectable virus-induced cytopathic effect at the light microscopy level and only slight alterations, consisting of small clusters of vacuoles, at the electron microscopy level. mitotic ... | 1973 | 4121707 |
| antitumor activity of silica gel pf 254 eluate. | 1973 | 4125149 | |
| stepwise degradation of poliovirus and top component by concentrated urea. | 1973 | 4125535 | |
| lack of close relationship between three strains of human rhinoviruses as determined by their rna sequences. | the possible genomic homologies between three serotypes of human rhinoviruses (hrv 1a, hrv 2, and hrv 14) were investigated. first we confirmed that these viruses were unrelated by the criterion of the absence of common antigenic determinants on the surfaces of the native virions, as detected by cross-neutralization of complementfixation. rna-rna hybridization was then examined with purified, highly radioactive, double-stranded, replicative-form rna and excess single-stranded virion rna. single- ... | 1973 | 4126194 |
| coupling of peroxidase to poliovirus antibody: characteristics of the conjugates and their use in virus detection. | antibody to poliovirus type 1 (po-1) was coupled to peroxidase by use of glutaraldehyde or 4, 4' -difluoro,3, 3' -dinitro diphenyl sulfone. glutaraldehyde was found to be the superior coupling agent, yielding conjugates that had up to 2.8 x 10(4) enzyme units/ml (75% of total enzyme input). conjugates migrated as a single band when centrifuged in sucrose density gradients, demonstrating that the purification procedure used was effective in removing both noncoupled enzyme and heterogeneous antibo ... | 1973 | 4126429 |
| subacute sclerosing panencephalitis and salk vaccine. | 1973 | 4126479 | |
| editorial: n.z. and s.s.p.e. | 1973 | 4126486 | |
| cultures of tissues from patients with amyotrophic lateral sclerosis. | 1973 | 4126530 | |
| letter: a possible association between paralytic poliomyelitis and multiple sclerosis. | 1973 | 4126643 | |
| structure and infectivity of picornaviral rna encapsidated by cowpea chlorotic mottle virus protein. | poliovirus and mengo virus rna were shown to associate efficiently with cowpea chlorotic mottle virus protein to form pseudovirions. the sedimentation coefficient for the pseudovirions was similar to that of poliovirus, and electron microscope observations showed the mengo pseudovirions to be similar in size to mengo virus. such pseudovirions were infectious and were more resistant to ribonuclease than viral rna; however, under our assay conditions, their infectivity was about equal to that of v ... | 1973 | 4128376 |
| temperature-sensitive poliovirus mutants defective in repression of host protein synthesis are also defective in structural protein. | 1973 | 4128480 | |
| the nucleic acid of infectious bronchitis virus. | 1973 | 4129679 | |
| measles virus antibodies in multiple sclerosis. comparison of antibody titers in cerebrospinal fluid and serum. | 1974 | 4131598 | |
| live-virus vaccines in pregnancy. risks and recommendations. | 1974 | 4134420 | |
| techniques applicable to computer-aided cytophotometry in virology. | 1974 | 4137231 | |
| in vitro effects of silicotungstate on some rna viruses. | 1973 | 4139979 | |
| factors affecting the efficacy of live poliovirus vaccine in warm climates. efficacy of type 1 sabin vaccine administered together with antihuman gamma-globulin horse serum to breast-fed and artificially fed infants in uganda. | a virologically controlled field trial was conducted with live monovalent type 1 poliovirus vaccine in children aged 3-30 months living in a rural area of uganda, in an attempt to find out the reason for the poor efficacy of such vaccine often observed in countries with a warm climate. groups of breast-fed and of artificially fed infants received the vaccine orally, either alone or mixed with horse serum prepared against partly purified human gamma-globulin. irrespective of the diet, the "take r ... | 1974 | 4142936 |
| [experimental study on the adsorption of poliomyelitis-vaccination virus type 2, during filtration through millipore-membrane filters]. | 1972 | 4145475 |