Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| curcumin induces apoptosis in human colorectal carcinoma (hct-15) cells by regulating expression of prp4 and p53. | curcumin (diferuloylmethane), the yellow pigment of turmeric, is one of the most commonly used and extensively studied phytochemicals due to its pleiotropic effects in several human cancers. in the current study, the therapeutic efficacy of curcumin was investigated in human colorectal carcinoma hct-15 cells. curcumin inhibited hct-15 cells proliferation and induced apoptosis in a dose- and time-dependent manner. hoechst 33342 and dcfhda staining revealed morphological and biochemical features o ... | 2013 | 23686430 |
| total and inorganic arsenic contents in some edible zingiberaceous rhizomes in thailand. | the arsenic accumulation in rhizomes of zingiberaceous plants was determined by atomic absorption spectrometry interfaced with hydride generation system (hg-aas). the raw herbal materials, rhizomes, were collected from different regions of thailand between december 2011 and january 2012. six well-known zingiberaceous plants, 16 samples from each and a total of 96 samples, were analyzed alpinia galanga (khaa), boesenbergia rotunda (kra-chaai), curcuma longa (khamin-chan), curcuma zedoaria (khamin ... | 2013 | 23690845 |
| plant-derived anticancer agents - curcumin in cancer prevention and treatment. | nowadays cancer is still a major public health issue. despite all the progresses made in cancer prevention, diagnosis and treatment, mortality by cancer is on the second place after the one caused by cardiovascular diseases. the high mortality and the increasing incidence of certain cancers (lung, prostate, colorectal) justify a growing interest for the identification of new pharmacological agents efficient in cancer prevention and treatment. in the last fifty years many plant-derived agents (vi ... | 2012 | 23700916 |
| [the prevalence of alternative herbal medicine and nutritional complementary product intake in patients admitted to out-patient cardiology departments]. | to detect the prevalence of alternative herbal medicine and nutritional complementary product intake in patients admitted to outpatient cardiology clinics and to determine demographic characteristics, comorbidities and medical properties of those patients. | 2013 | 23703557 |
| novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment. | curcumin (cur), a naturally occurring polyphenol derived from the root of curcuma longa, has showed potent anticancer and cancer prevention activity in a variety of cancers. however, the clinical translation of cur has been significantly hampered due to its extensive degradation, suboptimal pharmacokinetics, and poor bioavailability. to address these clinically relevant issues, we have developed a novel cur-loaded magnetic nanoparticle (mnp-cur) formulation. herein, we have evaluated the in vitr ... | 2013 | 23704793 |
| modulation of protein quality control systems by food phytochemicals. | there is compelling evidence showing that dietary phytochemicals have exhibited pronounced bioactivities in a number of experimental models. in addition, a variety of epidemiological surveys have demonstrated that frequent ingestion of vegetables and fruits, which contain abundant phytochemicals, lowers the risk of onset of some diseases. however, the action mechanisms by which dietary phytochemicals show bioactivity remain to be fully elucidated and a fundamental question is why this class of c ... | 2013 | 23704811 |
| determination of mercury in ayurvedic dietary supplements that are not rasa shastra using the hydra-c direct mercury analyzer. | mercury has been determined in ayurvedic dietary supplements (trifala, trifala guggulu, turmeric, mahasudarshan, yograj, shatawari, hingwastika, shatavari, and shilajit) by inductively coupled plasma-mass spectrometry (icp-ms) and direct mercury analysis using the hydra-c direct mercury analyzer (teledyne leeman labs hudson, nh, usa). similar results were obtained from the two methods, but the direct mercury analysis method was much faster and safer and required no microwave digestion (unlike ic ... | 2013 | 23710181 |
| an in vitro evaluation of the antimicrobial efficacy of curcuma longa, tachyspermum ammi, chlorhexidine gluconate, and calcium hydroxide on enterococcus faecalis. | this in vitro study was designed to comparatively evaluate the antimicrobial efficacy of curcuma longa (turmeric - t1-10%, t2-20%); tachyspermum ammi (ajwain - a1-10%, a2-20%); chlorhexidine (chx) gluconate gel (hexigel - 1%); and calcium hydroxide (10%) as intracanal medicaments against enterococcus faecalis. | 2013 | 23716967 |
| in vitro evaluation of five different herbal extracts as an antimicrobial endodontic irrigant using real time quantitative polymerase chain reaction. | sodium hypochlorite is the most commonly used irrigant but it has disadvantage like high cytotoxicity. so there is a need to find an alternative to 5.25% sodium hypochlorite against microorganism enterococcus faecalis and candida albicans. literature has shown that these 5 extracts namely terminalia chebula, myristica frangrans, aloe barbadensis, curcuma longa and azadaricta indica has good properties which can be used as a potential endodontic irrigant. | 2013 | 23716972 |
| antinociceptive curcuminoid, kms4034, effects on inflammatory and neuropathic pain likely via modulating trpv1 in mice. | curcumin, the active ingredient of turmeric (curcuma longa), has a wide range of beneficial effects including anti-inflammation and analgesia. however, poor bioavailability of curcumin hinders its clinical application. to overcome this limitation, we modified the structure of curcumin and synthesized new derivatives with favourable pharmacokinetic profiles. recently, curcumin has been shown to have an antagonizing effect on transient receptor potential vanilloid type 1 (trpv1) ion channels. we i ... | 2013 | 23719767 |
| surface-enhanced raman spectroscopy studies of yellow organic dyestuffs and lake pigments in oil paint. | identifying natural, organic dyes and pigments is important for the conservation, preservation, and historical interpretation of works of art. although previous sers studies have demonstrated high sensitivity and selectivity for red lake pigments using various pretreatment conditions, corresponding investigations of yellow lake pigments and paints are relatively sparse. here, surface-enhanced raman scattering (sers) spectroscopy is used to identify a variety of yellow organic dyestuffs and lake ... | 2013 | 23722232 |
| curcumin suppresses migration and proliferation of hep3b hepatocarcinoma cells through inhibition of the wnt signaling pathway. | curcumin, the major phytochemical in turmeric, exerts anti‑proliferative, anticancer and anti‑inflammatory activities in various types of cancer cells. curcumin has been demonstrated to induce apoptosis through multiple signaling pathways; however, its association with survival pathways, including the wnt signaling pathway, is not fully understood. the wnt signaling pathway is involved in diverse functions, including cell development, growth and proliferation. this pathway is important for cance ... | 2013 | 23723038 |
| effects of turmeric on alzheimer's disease with behavioral and psychological symptoms of dementia. | we describe here three patients with the alzheimer's disease (ad) whose behavioral symptoms were improved remarkably as a result of the turmeric treatment, which is the traditional indian medicine. their cognitive decline and behavioral and psychological symptoms of dementia (bpsd) were very severe. all three patients exhibited irritability, agitation, anxiety, and apathy, two patients suffer from urinary incontinence and wonderings. they were prescribed turmeric powder capsules and started reco ... | 2012 | 23723666 |
| curcumin downregulates aquaporin-1 expression in cultured rat choroid plexus cells. | aquaporin-1 (aqp1) is a water channel that is highly expressed on the apical side of the choroid plexus epithelium (cp) and thought to be one of the major pathways for the high water permeability of this structure. blockade of aqp1 in the cp reduce the production of cerebrospinal fluid (csf). downregulation of aqp1 might be protective against some neurological disorders correlated with increased intracranial pressure and/or poor drainage of csf. curcumin, the major constituent of the rhizome of ... | 2013 | 23735000 |
| preparation of monodisperse curcumin-imprinted polymer by precipitation polymerization and its application for the extraction of curcuminoids from curcuma longa l. | a monodisperse molecularly imprinted polymer (mip) for curcumin was first prepared by precipitation polymerization using methacrylamide (mam) and 4-vinylpyridine as functional co-monomers, divinylbenzene as a crosslinker, and a mixture of acetonitrile and toluene as a porogen. the use of mam as the co-monomer resulted in the formation of a monodisperse mip and non-imprinted polymer (nip). mip and nip, respectively, were monodispersed with a narrow particle size distribution (3.3 ± 0.09 and 3.5 ± ... | 2013 | 23739751 |
| human papilloma virus 16 e6 protein as a target for curcuminoids, curcumin conjugates and congeners for chemoprevention of oral and cervical cancers. | curcumin (diferuloyl methane) and its naturally occurring analogs viz. demethoxy, bisdemethoxy and cyclocurcumin, present in rhizomes of curcuma species turmeric, have been shown to inhibit the proliferation of a wide variety of tumor cells. target nuclear protein hpv 16 e6 (pdb id: 2fk4) is the major protein actively participating in oral and cervical cancers. in silico studies indicate that curcumin and its natural analogs have effective binding with different active sites on hpv 16 e6 protein ... | 2013 | 23740392 |
| [study on optimal processing technology of three kinds of processed coptidis rhizoma]. | to optimize the processing technology of coptidis rhizoma and study the effects of different adjuvants on alkaloids during processing. | 2013 | 23750405 |
| curcumin: a boon to colonic diseases. | curcumin, a natural polyphenolic compound present in turmeric, exhibited multiple pharmacological activities. extensive studies in last two decade suggested that curcumin possesses anti-inflammatory, anticancer, antiviral, anti-amyloid, antiarthritic and antioxidant properties. the mechanism for these effects involves modulation of several signaling transduction pathways. various clinical studies have suggested that curcumin might be a potential candidate for the prevention and/or treatment of a ... | 2013 | 23768171 |
| antioxidant and anti-glycation activities correlates with phenolic composition of tropical medicinal herbs. | to determine the contribution of total phenolic content (tpc) in glycation inhibitory activity of common tropical medicinal food and spices with potential antioxidative properties. | 2013 | 23768830 |
| protective effects of ginger-turmeric rhizomes mixture on joint inflammation, atherogenesis, kidney dysfunction and other complications in a rat model of human rheumatoid arthritis. | besides joint destruction, extra-articular complications (outside the locomotor system) are frequent in rheumatoid arthritis (ra) patients, especially cardiovascular, hematological and metabolic disorders. here, we evaluated and compared the protective activity of two different doses of mixture of ginger and turmeric rhizomes powder (1 : 1) suspended in distilled water (gtaq) in alleviating both articular and extra-articular manifestations in rat adjuvant-induced arthritis (aia). | 2013 | 23773648 |
| demethoxycurcumin inhibits energy metabolic and oncogenic signaling pathways through ampk activation in triple-negative breast cancer cells. | demethoxycurcumin (dmc), curcumin (cur), and bisdemethoxycurcumin (bdmc) are major forms of curcuminoids found in the rhizomes of turmeric. this study examined the effects of three curcuminoid analogues on breast cancer cells. the results revealed that dmc demonstrated the most potent cytotoxic effects on breast cancer mda-mb-231 cells. compared with estrogen receptor (er)-positive or her2-overexpressing breast cancer cells, dmc demonstrated the most efficient cytotoxic effects on triple-negativ ... | 2013 | 23777448 |
| curcumin reduces streptococcus mutans biofilm formation by inhibiting sortase a activity. | sortase a is an enzyme responsible for the covalent attachment of pac proteins to the cell wall in streptococcus mutans. it has been shown to play a role in modulating the surface properties and the biofilm formation and influence the cariogenicity of s. mutans. curcumin, an active ingredient of turmeric, was reported to be an inhibitor for staphylococcus aureus sortase a. the aim of this study was to investigate the inhibitory ability of curcumin against s. mutans sortase a and the effect of cu ... | 2013 | 23778072 |
| novel curcumin oral delivery systems. | curcumin, a natural polyphenolic compound derived from turmeric (curcuma longa l), has proven to be a modulator of multiple intercellular signalling pathways linked to inflammation, to proliferation, growth, invasion, drug sensitivity, angiogenesis and metastasis of cancer cells. although curcumin has shown significant efficacy in cell culture studies, it has shown limited efficacy in clinical studies when administered in conventional oral formulations. this discrepancy is largely attributed to ... | 2013 | 23780965 |
| upregulation of extrinsic apoptotic pathway in curcumin-mediated antiproliferative effect on human pancreatic carcinogenesis. | pancreatic cancer is one of the most lethal human cancers, with almost identical incidence and mortality rates. curcumin, derived from the rhizome of curcuma longa, has a long history of use as coloring agent and for a wide variety of disorders. here, the antiproliferative activity of curcumin and its modulatory effect on gene expression of pancreatic cancer cell lines were investigated. the effect of curcumin on cellular proliferation and viability was monitored by sulphurhodamine b assay. apop ... | 2013 | 23794119 |
| immune-stimulatory and anti-inflammatory activities of curcuma longa extract and its polysaccharide fraction. | while curcuminoids have been reported to possess diverse biological activities, the anti-inflammatory activity of polar extracts (devoid of curcuminoids) of curcuma longa (c. longa) has seldom been studied. in this study, we have investigated immune-stimulatory and anti-inflammatory activities of an aqueous based extract of c. longa (nr-inf-02) and its fractions in presence and absence of mitogens. | 2013 | 23798880 |
| curcumin enhances the lung cancer chemopreventive efficacy of phospho-sulindac by improving its pharmacokinetics. | phospho-sulindac (ps) is a safe sulindac derivative with promising anticancer efficacy in colon cancer. we evaluated whether its combination with curcumin could enhance the efficacy in the treatment of lung cancer. curcumin, the principal bioactive component in turmeric, has demonstrated versatile capabilities to modify the therapeutic efficacy of a wide range of anticancer agents. here, we evaluated the effect of co-administration of curcumin on the anticancer activity of ps in a mouse xenograf ... | 2013 | 23807084 |
| antiproliferative activities of lesser galangal (alpinia officinarum hance jam1), turmeric (curcuma longa l.), and ginger (zingiber officinale rosc.) against acute monocytic leukemia. | acute monocytic leukemia (aml m5 or amol) is one of the several types of leukemia that are still awaiting cures. the use of chemotherapy for cancer management can be harmful to normal cells in the vicinity of the target leukemia cells. this study assessed the potency of the extracts from lesser galangal, turmeric, and ginger against aml m5 to use the suitable fractions in neutraceuticals. aqueous and organic solvent extracts from the leaves and rhizomes of lesser galangal and turmeric, and from ... | 2013 | 23819642 |
| curcumin induces apoptosis of hepg2 cells via inhibiting fatty acid synthase. | fatty acid synthase (fas) is highly expressed in many kinds of human cancers, including liver cancer. curcumin is the major active ingredient of curcuma longa and has long been used to treat a variety of maladies. in the present study, we investigated the potential use of curcumin as a kind of fas inhibitor for chemoprevention of liver cancer. curcumin induced hepg2 cell apoptosis with the ic50 value of 8.84 μg/ml. it inhibited intracellular fas activity, and downregulated expression and mrna le ... | 2014 | 23821378 |
| curcumin suppresses multiple dna damage response pathways and has potency as a sensitizer to parp inhibitor. | inhibitors of poly(adp-ribose) polymerase (parp) are promising anticancer drugs, particularly for the treatment of tumors deficient in the dna damage response (ddr). however, it is challenging to design effective therapeutic strategies for use of these compounds against cancers without ddr deficiencies. in this context, combination therapies in which parp inhibitors are used alongside ddr inhibitors have elicited a great deal of interest. curcumin, a component of turmeric (curcuma longa), has be ... | 2013 | 23825154 |
| curcumin inhibits imiquimod-induced psoriasis-like inflammation by inhibiting il-1beta and il-6 production in mice. | curcumin, a selective phosphorylase kinase inhibitor, is a naturally occurring phytochemical present in turmeric. curcumin has been confirmed to have anti-inflammatory properties in addition to the ability to decrease the expression of pro-inflammatory cytokines in keratinocytes. the interleukin-23 (il-23)/il-17a cytokine axis plays a critical role in the pathogenesis of psoriasis. here, we report that topical use of a curcumin gel formulation strongly inhibited imiquimod (imq)-induced psoriasis ... | 2013 | 23825622 |
| back to the roots: photodynamic inactivation of bacteria based on water-soluble curcumin bound to polyvinylpyrrolidone as a photosensitizer. | photodynamic inactivation (pdi), the light-induced and photosensitizer-mediated overproduction of reactive oxygen species in microorganisms, represents a convincing approach to treat infections with (multi-resistant) pathogens. due to its favourable photoactive properties combined with excellent biocompatibility, curcumin derived from the roots of turmeric (curcuma longa) has been identified as an advantageous photosensitizer for pdi. to overcome the poor water solubility and the rapid decay of ... | 2013 | 23828307 |
| the use of an anti-inflammatory supplement in patients with chronic kidney disease. | chronic kidney disease (ckd) is characterized by a continuous reduction in kidney function, increased inflammation, and reduced antioxidant capacity. the objective of this study was to assess the effects of a herbal supplement on systemic inflammation and antioxidant status in non-dialysis ckd patients. sixteen patients with ckd (56.0±16.0 yrs, 171.4±11.9 cm, 99.3±20.2 kg) were randomly chosen to receive a herbal supplement composed of curcuma longa and boswellia serrata, or placebo. plasma leve ... | 2013 | 23828329 |
| crm1 is a cellular target of curcumin: new insights for the myriad of biological effects of an ancient spice. | curcumin is the major constituent of turmeric plant, an ancient spice widely used in indian cuisine and traditional herbal medicine. recently, the potential medical use of curcumin as anti-cancer and anti-inflammatory agent has set off an upsurge in research into the mechanism for its broad biological effects. we showed that crm1, an important nuclear exportin, is a cellular target of curcumin by serious experimental and theoretical investigation. using a nuclear export functional assay, we obse ... | 2013 | 23829533 |
| the binding of curcuma longa extract with bovine serum albumin monitored via time-resolved fluorescence. | turmeric (curcuma longa l.) is obtained from the rhizome of the zingberaceae family and has a long history as an ingredient in cooking. it has been used as a dye and recently research has concentrated on its possible health benefits, specifically because of its antioxidant activity. the principal compound that is responsible for this activity is curcumin, which is present with the other curcuminoids; demethoxycurcumin and bisdemethoxycurcumin. curcumin exhibits fluorescence and its photophysics ... | 2013 | 23829654 |
| efficacy and safety of curcumin in major depressive disorder: a randomized controlled trial. | curcumin, an active ingredient of curcuma longa linn (zingiberaceae), has shown potential antidepressant-like activity in animal studies. the objectives of this trial were to compare the efficacy and safety of curcumin with fluoxetine in patients with major depressive disorder (mdd). herein, 60 patients diagnosed with mdd were randomized in a 1:1:1 ratio for six weeks observer-masked treatment with fluoxetine (20 mg) and curcumin (1000 mg) individually or their combination. the primary efficacy ... | 2014 | 23832433 |
| preventive effects of curcumin against drug- and starvation-induced gastric erosions in rats. | the present study was designed to investigate the gastroprotective, analgesic, and antipyretic effects of curcumin (cur), the major constituent of turmeric. acetylsalicylic acid (asa) was used in this study as a standard drug for comparison. the analgesic activity was measured using the hot-plate test. the antipyretic and antiulcer effects were assessed using yeast-induced pyrexia and gastric ulceration, respectively. curcumin (100 mg/kg) injected intra-peritoneally 1 hr prior to the hot-plate t ... | 2017 | 23833720 |
| targeting proteasomal pathways by dietary curcumin for cancer prevention and treatment. | curcumin, a major component of the golden spice turmeric (curcuma longa), has been linked with the prevention and treatment of a wide variety of cancers through modulation of multiple cell signaling pathways. since the first report from our laboratory in 1995 that curcumin can inhibit activation of the proinflammatory transcription factor nf-κb by inhibiting the 26s proteasomal degradation of iκbα, an inhibitor of nf-κb, this yellow pigment has been shown to inhibit the protease activities of th ... | 2014 | 23834173 |
| the effect of curcumin on breast cancer cells. | curcumin, which is extracted from the plant curcuma longa, has been used in the therapeutic arsenal for clinical oncology. curcumin has chemopreventive and antitumoral activities against some aggressive and recurrent cancers. the expressions and activities of various proteins, such as inflammatory cytokines and enzymes, transcription factors, and gene-products linked with cell survivals and proliferation, can be modified by curcumin. moreover, curcumin decreases the toxic effect of mitomycin c. ... | 2013 | 23843843 |
| curcumin protects against 1-methyl-4-phenylpyridinium ion- and lipopolysaccharide-induced cytotoxicities in the mouse mesencephalic astrocyte via inhibiting the cytochrome p450 2e1. | curcumin is extracted from the rhizomes of the ginger family plant curcuma longa l., which has a good protection for liver, kidney, and immune system. however, there is little information about its contribution in protection of astrocytes recently. the present study was undertaken to elucidate the protective effect of curcumin, an herbal antioxidant, on 1-methyl-4-phenylpyridinium ion- (mpp(+)-) and lipopolysaccharide- (lps-) induced cytotoxicities, as well as the underlying mechanisms by using ... | 2013 | 23843878 |
| the multiple pharmaceutical potential of curcumin in parkinson's disease. | parkinson's disease (pd) is one of the most common neurodegenerative diseases in the elderly. in recent years increasing evidence supports the pharmaceutical potential of curcumin, a polyphenolic compound in the spice turmeric, against pd. here we briefly summarize the pharmacological activities of curcumin in vitro and in animal models of pd, including counteracting oxidative stress and inflammation, preventing α-synuclein aggregation and fibrillation, and inhibiting monoamine oxidase b, which ... | 2014 | 23844695 |
| curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: identification of novel components of turmeric. | turmeric, a dried powder derived from the rhizome of curcuma longa, has been used for centuries in certain parts of the world and has been linked to numerous biological activities including antioxidant, anti-inflammatory, anticancer, antigrowth, anti-arthritic, anti-atherosclerotic, antidepressant, anti-aging, antidiabetic, antimicrobial, wound healing, and memory-enhancing activities. one component of turmeric is curcumin, which has been extensively studied, as indicated by more than 5600 citat ... | 2013 | 23847105 |
| [study on effect of hypericum perforatum on pharmacokinetics of zedoary turmeric oil in compound antiviral preparation]. | to study zedoary turmeric oil (zto) and the pharmacokinetics of its homemade compound antiviral preparation in new zealand rabbits. | 2013 | 23847963 |
| curcumin potentiates the ability of sunitinib to eliminate the vhl-lacking renal cancer cells 786-o: rapid inhibition of rb phosphorylation as a preamble to cyclin d1 inhibition. | curcumin, an important component of the culinary spice turmeric, has been shown to harbor anticancer properties against a wide range of cancer cells with minimal toxicity toward normal cells. two general tyrosine kinase inhibitors (tkis) sunitinib and sorafenib are currently used in treating renal cancer. though the use of these tkis has significantly improved survival, both elicit distressing side effects, limiting their long-term use. we tested the activity of sunitinib and sorafenib to elimin ... | 2013 | 23848205 |
| garcinia benzophenones inhibit the growth of human colon cancer cells and synergize with sulindac sulfide and turmeric. | previous studies indicate that extracts and purified components from garcinia species inhibit the growth of human colon cancer cells. garcinia benzophenones activate the expression of genes in the endoplasmic reticulum and cellular energy stress (mtor) pathways. this study examines the growth inhibitory and synergistic effects of garcinia benzophenones, alone or combined with chemopreventive agents, on human colon cancer cells. to find optimal combination treatments, ht29 colon cancer cells were ... | 2013 | 23848206 |
| curcumin i mediates neuroprotective effect through attenuation of quinoprotein formation, p-p38 mapk expression, and caspase-3 activation in 6-hydroxydopamine treated sh-sy5y cells. | 6-hydroxydopamine (6-ohda) selectively enters dopaminergic neurons and undergoes auto-oxidation resulting in the generation of reactive oxygen species and dopamine quinones, subsequently leading to apoptosis. this mechanism mimics the pathogenesis of parkinson's disease and has been used to induce experimental parkinsonism in both in vitro and in vivo systems. in this study, we investigated the effects of curcumin i (diferuloylmethane) purified from curcuma longa on quinoprotein production, phos ... | 2014 | 23857913 |
| therapeutic potential of turmeric in alzheimer's disease: curcumin or curcuminoids? | alzheimer's disease (ad) is the most common form of dementia. there is limited choice in modern therapeutics, and drugs available have limited success with multiple side effects in addition to high cost. hence, newer and alternate treatment options are being explored for effective and safer therapeutic targets to address ad. turmeric possesses multiple medicinal uses including treatment for ad. curcuminoids, a mixture of curcumin, demethoxycurcumin, and bisdemethoxycurcumin, are vital constituen ... | 2014 | 23873854 |
| antidepressant-like effects of curcumin in chronic mild stress of rats: involvement of its anti-inflammatory action. | mounting evidence suggests that inflammation may contribute to the pathophysiology of depression. curcumin, a polyphenol extracted from the plant curcuma longa, exhibits a number of pharmacological properties, including potent anti-inflammatory action. hence, the current study aimed to explore the immunomodulatory effects of curcumin in an animal model of chronic mild stress (cms). rats were subjected to cms protocol for a period of 21 days to induce depressive-like behavior. the body weight, su ... | 2013 | 23876788 |
| sirt1 activation by curcumin pretreatment attenuates mitochondrial oxidative damage induced by myocardial ischemia reperfusion injury. | ischemia reperfusion (ir) injury (iri) is harmful to the cardiovascular system and causes mitochondrial oxidative stress. silent information regulator 1 (sirt1), a type of histone deacetylase, contributes to iri. curcumin (cur) is a strong natural antioxidant and is the active component in curcuma longa; cur has protective effects against iri and may regulate the activity of sirt1. this study was designed to investigate the protective effect of cur pretreatment on myocardial iri and to elucidate ... | 2013 | 23880291 |
| curcumin induces apoptosis in human gastric carcinoma ags cells and colon carcinoma ht-29 cells through mitochondrial dysfunction and endoplasmic reticulum stress. | in the present study, we investigate the effect of curcumin, a major active component isolated from rhizomes of curcuma longa, on the cytotoxicity of three human carcinoma cell lines (ags, ht-29 and mgc803) in gastrointestinal tract and a normal gastric epithelial cell line ges-1, and the mechanism of curcumin-induced apoptosis. the results indicated that curcumin inhibited the gastrointestinal carcinoma cell growth in a dose-dependent manner and cytotoxicity was more towards the gastric carcino ... | 2013 | 23881281 |
| molecular modeling and docking characterization of czr1, a cc-nbs-lrr r-gene from curcuma zedoaria loeb. that confers resistance to pythium aphanidermatum. | plant nbs-lrr r-genes recognizes several pathogen associated molecular patterns (pamps) and limit pathogen infection through a multifaceted defense response. czr1, a coiled-coil-nucleotide-binding-site-leucine-rich repeat r-gene isolated from curcuma zedoaria l exhibit constitutive resistance to different strains of p. aphanidermatum. majority of the necrotrophic oomycetes are characterized by the presence of carbohydrate pamps β-glucans in their cell walls which intercat with r-genes. in the pr ... | 2013 | 23888096 |
| effect of curcumin against pentylenetetrazol-induced seizure threshold in mice: possible involvement of adenosine a1 receptors. | curcumin, obtained from curcuma longa, has been in use for manifold human disorders. the present study explores the effect of curcumin against pentylenetetrazol (ptz) seizure threshold in mice. the possible involvement of adenosine receptor(s) mechanism was also investigated. minimal dose of ptz (i.v., mg/kg) needed to induce different phases of convulsions were recorded as an index of seizure threshold. curcumin (20-120 mg/kg, p.o.) produced an increase in seizure threshold for convulsions indu ... | 2014 | 23893477 |
| composition and antimicrobial activity of the essential oil from leaves of curcuma longa l. kasur variety. | the essential oil from the leaves of curcuma longa l. kasur variety grown in pakistan was extracted by hydro-distillation. chemical constituents of the essential oil were identified by gas chromatography/mass spectrometry. the chromatographic analysis of oil showed 25 constituents, out of which nine chemical constituents were identified. the eucalyptol (10.27%) was the major component of the essential oil. α-pinene (1.50%), β-phellandrene (2.49%), β-pinene (3.57%), limonene (2.73%), 1,3,8-p-ment ... | 2013 | 23901173 |
| curcumin: a novel therapeutic for burn pain and wound healing. | managing burn injury-associated pain and wounds is a major unresolved clinical problem. opioids, nonsteroidal antiinflammatory drugs (nsaids), antidepressants and anticonvulsants remain the most common forms of analgesic therapy to treat burn patients. however, prolonged treatment with these drugs leads to dose escalation and serious side effects. additionally, severe burn wounds cause scarring and are susceptible to infection. recent encouraging findings demonstrate that curcumin, a major bioac ... | 2013 | 23902423 |
| neuroprotective effects of curcumin and highly bioavailable curcumin on oxidative stress induced by sodium nitroprusside in rat striatal cell culture. | curcumin, a polyphenolic compound extracted from curcuma longa, has several pharmacological activities such as anticancer, anti-inflammatory, and antioxidant effects. the purpose of this study was to investigate the protective effects of curcumin and theracurmin, a highly bioavailable curcumin, against sodium nitroprusside (snp)-induced oxidative damage in primary striatal cell culture. theracurmin as well as curcumin significantly prevented snp-induced cytotoxicity. to elucidate the cytoprotect ... | 2013 | 23902979 |
| turmeric curcumin inhibits entry of all hepatitis c virus genotypes into human liver cells. | hepatitis c virus (hcv) infection causes severe liver disease and affects more than 160 million individuals worldwide. people undergoing liver organ transplantation face universal re-infection of the graft. therefore, affordable antiviral strategies targeting the early stages of infection are urgently needed to prevent the recurrence of hcv infection. the aim of the study was to determine the potency of turmeric curcumin as an hcv entry inhibitor. | 2014 | 23903236 |
| production of l- and d-lactic acid from waste curcuma longa biomass through simultaneous saccharification and cofermentation. | simultaneous saccharification and cofermentation (sscf) of curcuma longa waste biomass obtained after turmeric extraction to l- and d-lactic acid by lactobacillus coryniformis and lactobacillus paracasei, respectively, was investigated. this is a rich, starchy, agro-industrial waste with potential for use in industrial applications. after optimizing the fermentation of the biomass by adjusting nitrogen sources, enzyme compositions, nitrogen concentrations, and raw material concentrations, the ss ... | 2013 | 23911815 |
| are curcuminoids effective c-reactive protein-lowering agents in clinical practice? evidence from a meta-analysis. | inflammation plays a pivotal role in the pathogenesis of atherosclerosis and cardiovascular disease (cvd). in this context, c-reactive protein (crp) has been identified as a strong predictor and independent risk factor of cvd. curcuminoids are multifunctional natural product with promising cardioprotective and anti-inflammatory properties. curcuminoids have been suggested to lower circulating levels of crp, but clinical findings have not been consistent. | 2014 | 23922235 |
| turmeric (curcumin) remedies gastroprotective action. | the purpose of this review is to summarize the pertinent literature published in the present era regarding the antiulcerogenic property of curcumin against the pathological changes in response to ulcer effectors (helicobacter pylori infection, chronic ingestion of non-steroidal anti-inflammatory drugs, and exogenous substances). the gastrointestinal problems caused by different etiologies was observed to be associated with the alterations of various physiologic parameters such as reactive oxygen ... | 2013 | 23922455 |
| neuroprotective properties of curcumin in alzheimer's disease--merits and limitations. | as demographics in developed nations shift towards an aging population, neurodegenerative pathologies, especially dementias such as alzheimer's disease, pose one of the largest challenges to the modern health care system. since there is yet no cure for dementia, there is great pressure to discover potential therapeutics for these diseases. one popular candidate is curcumin or diferuloylmethane, a polyphenolic compound that is the main curcuminoid found in curcuma longa (family zingiberaceae). in ... | 2013 | 23931272 |
| protection from uvb toxicity in human keratinocytes by thailand native herbs extracts. | thai traditional medicine employs a wide range of indigenous herbs in the forms of tincture or tea for the cure of skin and systemic inflammatory diseases. the protection by thai plants extracts against uvb dna damage and cytotoxicity was investigated in human keratinocytes. petroleum ether, dichloromethane and ethanol extracts were prepared from 15 thai herb species, and the total phenolic and flavonoid contents, the antioxidant and uv-absorbing properties were assessed by standard procedures. ... | 2014 | 23931284 |
| curcumin pretreatment attenuates brain lesion size and improves neurological function following traumatic brain injury in the rat. | turmeric has been in use since ancient times as a condiment and due to its medicinal properties. curcumin, the yellow coloring principle in turmeric, is a polyphenolic and a major active constituent. besides anti-inflammatory, thrombolytic and anti-carcinogenic activities, curcumin also possesses strong antioxidant property. the neuroprotective effects of curcumin were evaluated in a weight drop model of cortical contusion trauma in rat. male wistar rats (350-400 g, n=9) were anesthetized with s ... | 2013 | 23932920 |
| curcumin protects microglia and primary rat cortical neurons against hiv-1 gp120-mediated inflammation and apoptosis. | curcumin is a molecule found in turmeric root that has anti-inflammatory, antioxidant, and anti-tumor properties and has been widely used as both an herbal drug and a food additive to treat or prevent neurodegenerative diseases. to explore whether curcumin is able to ameliorate hiv-1-associated neurotoxicity, we treated a murine microglial cell line (n9) and primary rat cortical neurons with curcumin in the presence or absence of neurotoxic hiv-1 gp120 (v3 loop) protein. we found that hiv-1 gp12 ... | 2013 | 23936448 |
| curcumin binds tubulin, induces mitotic catastrophe, and impedes normal endothelial cell proliferation. | curcumin, a component of turmeric spice that imparts flavor and color to curry, is thought to possess anti-inflammatory and antioxidant properties in biological tissues. however, while such efficacies have been described in the context of carcinogenesis, the impact of curcumin on normal cell cycle regulation is poorly understood. here, we provide evidence of curcumin toxicity in proliferating bovine aortic endothelial cells, at concentrations relevant to the diet and below those previously repor ... | 2013 | 23939039 |
| bisdemethoxycurcumin suppresses mcf-7 cells proliferation by inducing ros accumulation and modulating senescence-related pathways. | bisdemethoxycurcumin (bdmc) is a natural derivative of curcumin present in the phenolic components extracted from the dried rhizome of curcuma longa l. bdmc demonstrated potential chemotherapeutic activities but the underlying mechanisms have not been fully clarified. in the present study, the role of reactive oxidative species (ros) in the anti-cancer effects of bdmc was investigated. | 2013 | 23950593 |
| curcumin analog 1, 5-bis (2-trifluoromethylphenyl)-1, 4-pentadien-3-one exhibits enhanced ability on nrf2 activation and protection against acrolein-induced arpe-19 cell toxicity. | curcumin, a phytochemical agent in the spice turmeric, has received increasing attention for its anticancer, anti-inflammatory and antioxidant properties. however, application of curcumin has been limited due to its insolubility in water and poor bioavailability both clinically and experimentally. in addition, the protective effects and mechanisms of curcumin in eye diseases have been poorly studied. in the present study, we synthesized a curcumin analog, 1, 5-bis (2-trifluoromethylphenyl)-1, 4- ... | 2013 | 23954767 |
| curcumin pretreatment prevents potassium dichromate-induced hepatotoxicity, oxidative stress, decreased respiratory complex i activity, and membrane permeability transition pore opening. | curcumin is a polyphenol derived from turmeric with recognized antioxidant properties. hexavalent chromium is an environmental toxic and carcinogen compound that induces oxidative stress. the objective of this study was to evaluate the potential protective effect of curcumin on the hepatic damage generated by potassium dichromate (k2cr2o7) in rats. animals were pretreated daily by 9-10 days with curcumin (400 mg/kg b.w.) before the injection of a single intraperitoneal of k2cr2o7 (15 mg/kg b.w.) ... | 2013 | 23956771 |
| biological effects of some natural and chemical compounds on the potato tuber moth, phthorimaea operculella zell. (lepidoptera:gelechiidae). | the olfactory reaction of larvae and moths was investigated towards 18 oils (6 natural oils and 12 commercial chemical oils). some of these oils such as peppermint and camphor (natural oils) and eugenol and camphene (commercial oils) were repellent to both larvae and moths. other oils such as strawberry and d-limonene were attractive to both larvae and moths. some of the repellent oils were, therefore, tested for their effect on certain biological aspects of the insects. eugenol and peppermint o ... | 0 | 23961036 |
| the efficacy of curcuma longa l. extract as an adjuvant therapy in primary knee osteoarthritis: a randomized control trial. | nonsteroidal anti-inflammatory drugs (nsaids) is one of the most commonly use medication for treatment of knee osteoarthritis which has the analgesic and anti-inflammation by inhibition of prostaglandin synthesis via cox-1 and cox-2 isoenzyme. the problem of prolong using nsaids has side effect on kidney, liver and gi system. curcumin longa extract curcumin) is the asian herbal medicine that has the anti-inflammatory effect by down regulate activation of nf-kappab and proinflammatory cytokines s ... | 2012 | 23964444 |
| design and in vitro evaluation of a new nano-microparticulate system for enhanced aqueous-phase solubility of curcumin. | curcumin, a yellow polyphenol derived from the turmeric curcuma longa, has been associated with a diverse therapeutic potential including anti-inflammatory, antioxidant, antiviral, and anticancer properties. however, the poor aqueous solubility and low bioavailability of curcumin have limited its potential when administrated orally. in this study, curcumin was encapsulated in a series of novel nano-microparticulate systems developed to improve its aqueous solubility and stability. the nano-micro ... | 2013 | 23984402 |
| curcumin protects rat heart mitochondria against anoxia-reoxygenation induced oxidative injury. | it is an important therapeutic strategy to protect mitochondria from oxidative stress, especially during ischemia-reperfusion. curcumin is a naturally occurring phenolic compound isolated as a yellow pigment from turmeric (curcuma longa). this compound has received much attention due to its diversity of biological and pharmacological activities. in this study, an attempt has been made to evaluate the protective effects of curcumin on rat heart mitochondrial injuries induced by in vitro anoxia-re ... | 2013 | 23984717 |
| effect of tea, coffee and turmeric solutions on the colour of denture base acrylic resin: an in vitro study. | discoloration of acrylic resin denture base when it comes in contact with various food materials and beverages in the oral cavity may cause aesthetic concern to a denture wearer. the objective of this study was to evaluate the effect of tea, coffee and turmeric solutions on the colour of different brands of heat cure acrylic resin denture base materials commonly used in india. spectrophotometer was used to evaluate the colour change. a significant difference was found when change in colour was s ... | 2012 | 23997464 |
| clinical evaluation of a formulation containing curcuma longa and boswellia serrata extracts in the management of knee osteoarthritis. | a formulation containing curcuma longa and boswellia serrata extracts (cb formulation) was evaluated for safety and efficacy in osteoarthritic patients and directly compared with the selective cox-2 inhibitor, celecoxib. in total, 54 subjects were screened, 30 subjects were enrolled and 28 completed the study. the treatment was well tolerated and did not produce any adverse effect in patients, as judged by the vital signs, hemogram, liver and renal function tests. the cb formulation at 500 mg ad ... | 2013 | 24002213 |
| antiepileptogenic effect of curcumin on kainate-induced model of temporal lobe epilepsy. | temporal lobe epilepsy (tle) is an intractable neurological disorder. curcumin is the bioactive component of turmeric with anti-epileptic and neuroprotective potential. | 2013 | 24004105 |
| curcumin abrogates lps-induced pro-inflammatory cytokines in raw 264.7 macrophages. evidence for novel mechanisms involving socs-1, -3 and p38 mapk. | curcumin is the active compound in the extract of curcuma longa rhizomes with anti-inflammatory properties mediated by inhibition of intracellular signalling. socs and mapkinases are involved in the signalling events controlling the expression of il-6, tnf-α and pge2, which have important roles on chronic inflammatory diseases. the aim was to assess if these pathways are involved in curcumin-mediated effects on lps-induced expression of these cytokines in macrophages. raw 264.7 murine macrophage ... | 2013 | 24011306 |
| induction with ncb-02 (curcumin) enema for mild-to-moderate distal ulcerative colitis - a randomized, placebo-controlled, pilot study. | curcumin, an active ingredient of turmeric with anti-inflammatory properties, has been demonstrated to be useful in experimental models of ulcerative colitis (uc). it's efficacy in humans needs to be investigated. | 2014 | 24011514 |
| rapid separation and quantitation of curcuminoids combining pseudo two-dimensional liquid flash chromatography and nmr spectroscopy. | rapid separation, characterization and quantitation of curcuminoids are important owing to their numerous pharmacological properties including antimicrobial, antiviral, antifungal, anticancer, and anti-inflammatory activities. in the present study, pseudo two-dimensional liquid flash chromatography was used for the separation of four curcuminoids (curcumin, demethoxy curcumin, bisdemethoxy curcumin and dihydro bisdemethoxy curcumin) for the first time. silica and diol columns were used for separ ... | 2013 | 24013126 |
| evaluation of antioxidant, antimutagenic, and lipid peroxidation inhibitory activities of selected fractions of holarrhena floribunda (g. don) leaves. | exposure to environmental pollutants often leads to an upsurge in the production of reactive oxygen species (ros). ros oxidize cellular fatty acids to produce lipid peroxyl radicals, subsequently transformed into lipid peroxides, which decrease membrane fluidity and increase the activity of various enzymes implicated in degenerative diseases and cancer formation. edible plants that contain exogenous compounds like curcumeroid, β-carotene, turmeric, and so on, protect the aerobic cells from oxida ... | 2013 | 24020060 |
| intranasal curcumin and its evaluation in murine model of asthma. | curcumin, a phytochemical present in turmeric, rhizome of curcuma longa, has been shown to have a wide variety of pharmacological activities including anti-inflammatory, anti-allergic and anti-asthmatic properties. curcumin is known for its low systemic bioavailability and rapid metabolization through oral route and has limited its applications. over the recent decades, the interest in intranasal delivery as a non-invasive route for drugs has increased as target tissue for drug delivery since na ... | 2013 | 24021755 |
| curcumin conjugated silica nanoparticles for improving bioavailability and its anticancer applications. | curcumin, a yellow bioactive component of indian spice turmeric, is known to have a wide spectrum of biological applications. in spite of various astounding therapeutic properties, it lacks in bioavailability mainly due to its poor solubility in water. in this work, we have conjugated curcumin with silica nanoparticles to improve its aqueous solubility and hence to make it more bioavailable. conjugation and loading of curcumin with silica nanoparticles was further examined with transmission elec ... | 2013 | 24028689 |
| characterization of synergistic anti-cancer effects of docosahexaenoic acid and curcumin on dmba-induced mammary tumorigenesis in mice. | the major obstacles to the successful use of individual nutritional compounds as preventive or therapeutic agents are their efficacy and bioavailability. one approach to overcoming this problem is to use combinations of nutrients to induce synergistic effects. the objective of this research was to investigate the synergistic effects of two dietary components: docosahexaenoic acid (dha), an omega-3 fatty acid present in cold-water fish, and curcumin (ccm), an herbal nutrient present in turmeric, ... | 2013 | 24034496 |
| dietary plant extracts alleviate diarrhea and alter immune responses of weaned pigs experimentally infected with a pathogenic escherichia coli. | a study was conducted to evaluate the effects of 3 different plant extracts on diarrhea, immune response, intestinal morphology, and growth performance of weaned pigs experimentally infected with a pathogenic f-18 escherichia coli (e. coli). sixty-four weaned pigs (6.3±0.2 kg bw, and 21 d old) were housed in individual pens in disease containment chambers for 15 d: 4 d before and 11 d after the first inoculation (d 0). treatments were in a 2×4 factorial arrangement: with or without an f-18 e. co ... | 2013 | 24045466 |
| dietary curcuma longa enhances resistance against eimeria maxima and eimeria tenella infections in chickens. | the effects of dietary supplementation with an organic extract of curcuma longa on systemic and local immune responses to experimental eimeria maxima and eimeria tenella infections were evaluated in commercial broiler chickens. dietary supplementation with c. longa enhanced coccidiosis resistance as demonstrated by increased bw gains, reduced fecal oocyst shedding, and decreased gut lesions compared with infected birds fed a nonsupplemented control diet. the chickens fed c. longa-supplemented di ... | 2013 | 24046410 |
| curcumin induces autophagy via activating the ampk signaling pathway in lung adenocarcinoma cells. | curcumin is a major yellow pigment and active component of turmeric widely used as dietary spice and herbal medicine. this compound has been reported to be a promising antitumor agent, although the underlying molecular mechanisms are not fully understood yet. in this study, we reported that curcumin inhibited growth of lung adenocarcinoma cells, but had no cytotoxic activity to imr-90 normal lung fibroblast cells. curcumin induced autophagy in the a549 human lung adenocarcinoma cell line, eviden ... | 2013 | 24048094 |
| protective effect of curcuminoids on age-related mitochondrial impairment in female wistar rat brain. | the present study demonstrated the neuroprotective effect of curcuminoids, the active polyphenols of curcuma longa (l.) rhizomes on mitochondrial dysfunctioning in middle aged and aged female wistar rat brain. rats were orally treated with curcuminoids (100 mg/kg) for 3 months and their brain was collected for evaluation of mitochondrial enzymes and complexes activity, ultra structural changes in mitochondria, neuronal nitric oxide synthase (nnos) protein expression, adenosine triphosphate (atp) ... | 2014 | 24048922 |
| effect of fungicides and plant extracts on the conidial germination of colletotrichum gloeosporioides causing mango anthracnose. | in northern bangladesh, generally mango trees are planted as agroforest that gives higher net present value (npv) than traditional agriculture. mango anthracnose caused by colletotrichum gloeosporioides penz. is seen as a very destructive and widely distributed disease, which results in poor market value. five fungicides such as cupravit, bavistin, dithane m-45, thiovit and redomil were tested against conidial germination of c. gloeosporioides. dithane m-45 and redomil were the most effective wh ... | 2005 | 24049501 |
| curcumin suppresses proliferation and induces apoptosis of human hepatocellular carcinoma cells via the wnt signaling pathway. | curcumin from the rhizome of curcuma longa (zingiberaceae) has been reported to be a chemopreventive agent that affects cell proliferation by arresting the cell cycle in g2 and modulating the wnt signaling pathway. we found that curcumin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma (hcc) cells in a concentration-dependent manner. we identified that curcumin interrupts wnt signaling by decreasing β-catenin activity, which in turn suppresses the expression of β-ca ... | 2013 | 24064724 |
| antidermatophytic properties of ar-turmerone, turmeric oil, and curcuma longa preparations. | curcuma longa l. or turmeric of the family zingiberaceae is widely used in thai traditional medicines for the treatment of rash, itching, tinea, and ringworm. previous studies on turmeric oil reported effective antifungal activity against dermatophytes, a group of fungi that causes skin diseases. in this study, turmeric creams containing 6 and 10% w/w turmeric oil were prepared and tested against clinical strains of dermatophytes using broth dilution technique. minimum fungicidal concentrations ... | 2013 | 24066236 |
| updated review of complementary and alternative medicine treatments for systemic lupus erythematosus. | it is estimated that over 50 % of patients with systemic lupus erythematosus (sle) have utilized complementary and alternative medicine (cam) treatments to reduce symptoms and manage their health. however, there are relatively few randomized controlled trials of cam for sle. this review describes recent studies of vitamins and supplements, acupuncture, and mind-body interventions in sle patients. the recent trials of cam treatments for sle indicate that supplements such as vitamin d, omega 3 fat ... | 2013 | 24078104 |
| the novel heterocyclic trioxirane [(1,3,5-tris oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione (tatt)] exhibits a better anticancer effect than platinum-based chemotherapy by induction of apoptosis and curcumin further enhances its chemosensitivity. | the heterocyclic trioxirane compound [1,3,5-tris((oxiran-2-yl)methyl)-1,3,5-triazinane-2,4,6-trione (tatt)] is a synthetic compound which has been used as an experimental anticancer agent in human clinical trials. curcumin, an active natural compound in turmeric and curry, is an ingredient commonly used in the traditional diet of many asian countries. in the present study, we observed that tatt exhibited a better anticancer effect on chemoresistant human colorectal cancer ht-29 cells and display ... | 2014 | 24078402 |
| hplc-ms and gc-ms analyses combined with orthogonal partial least squares to identify cytotoxic constituents from turmeric (curcuma longa l.). | we investigated the fingerprints of 48 batches of turmeric total extracts (tte) by hplc-ms-ms and gc-ms analyses and 43 characteristic peaks (22 constituents from hplc-ms-ms; 21 from gc-ms) were analyzed qualitatively and quantitatively. an mtt {3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide} assay was implemented to measure the cytotoxicity of the tte against hela cells. then we utilized orthogonal partial least squares analysis, which correlated the chemical composition of the t ... | 2013 | 24079186 |
| bacteriology of a most popular street food (panipuri) and inhibitory effect of essential oils on bacterial growth. | bacteriology of panipuri was studied and the antibacterial effect of eight essential oils (eos) was established on pathogens found in panipuri. samples were collected from twelve respective vendors from different locations in baripada city, orissa. samples were fractionated into two parts viz. khatta pani and smashed potato masala used in panipuri. total plate count and isolation of pathogenic bacteria were done on both basal and selective media. coliforms were detected primarily by presumptive ... | 2012 | 24082267 |
| curcumin: a novel treatment for skin-related disorders. | curcumin, or diferuloylmethane, is a crystalline compound which gives the east asian spice turmeric its bright yellow color. the medicinal properties of this spice have been referenced in numerous countries and cultures throughout the world. today, there is growing scientific evidence suggesting curcumin's utility in the treatment of chronic pain, inflammatory dermatoses, acceleration of wound closure, skin infections, as well as cosmetic ailments such as dyspigmentation. in addition, curcumin m ... | 2013 | 24085048 |
| do plants mediate their anti-diabetic effects through anti-oxidant and anti-apoptotic actions? an in vitro assay of 3 indian medicinal plants. | both experimental and clinical studies suggest that oxidative stress plays a major role in the pathogenesis of both types of diabetes mellitus. this oxidative stress leads to β-cell destruction by apoptosis. hence exploring agents modulating oxidative stress is an effective strategy in the treatment of both type i and type ii diabetes. plants are a major source of anti-oxidants and exert protective effects against oxidative stress in biological systems. phyllanthus emblica, curcuma longa and tin ... | 2013 | 24093976 |
| assessment of metal contents in spices and herbs from saudi arabia. | in the recent years, there has been a growing interest in monitoring heavy metal contamination of spices/herbs. spices and herbs are sources of many bioactive compounds that can improve the tastes of food as well as influence digestion and metabolism processes. in the present study, the levels of some essential and toxic elements such as iron (fe), zinc (zn), copper (cu), chromium (cr), manganese (mn), cobalt (co), nickel (ni), lead (pb), and cadmium (cd), present in common spices/herbs that wer ... | 2016 | 24097370 |
| inhibition of anthrax lethal factor by curcumin and chemically modified curcumin derivatives. | curcumin (diferuloylmethane), the active ingredient in the eastern spice turmeric (curcuma longa), has been shown to inhibit the activities of numerous enzymes and signaling molecules involved in cancer, bacterial and viral infections and inflammatory diseases. we have investigated the inhibitory activities of curcumin and chemically modified curcumin (cmc) derivatives toward lethal factor (lf), the proteolytic component of anthrax toxin produced by the bacterium bacillus anthracis. curcumin (co ... | 2014 | 24102525 |
| acute effects of diesel exhaust particles and cisplatin on oxidative stress in cultured human kidney (hek 293) cells, and the influence of curcumin thereon. | particulate air pollution with particle diameters less than 2.5μm contribute to respiratory and extra-respiratory morbidity and mortality. we have recently reported the first in vivo experimental evidence that diesel exhaust particles (dep) in the lung aggravated the renal, pulmonary, and systemic effects of cisplatin (cp)-induced acute renal failure in rats. this in vitro study sought to determine whether and to what extent does dep exposure exacerbate the effects of cp-induced oxidative stress ... | 2013 | 24113306 |
| in vivo study on the effects of curcumin on the expression profiles of anti-tumour genes (vegf, cyclind1 and cdk4) in liver of rats injected with den. | in this study we investigated the effects of curcumin, derived from plant curcuma longa, on oxidative toxicity, and the possible molecular mechanism of antitumour of curcumin in liver cancer rats. results showed that blood levels of gamma-glutamyltransferase, aspartate aminotransferase, alanine aminotransferase, glutathione s-transferase, and liver level of md were significantly decreased after curcumin feeding. levels of the liver malondialdehyde mda, nitric oxide and antioxidant enzymes were s ... | 2013 | 24114697 |
| curcumin suppresses gelatinase b mediated norepinephrine induced stress in h9c2 cardiomyocytes. | extracellular matrix (ecm) remodeling facilitates biomechanical signals in response to abnormal physiological conditions. this process is witnessed as one of the major effects of the stress imposed by catecholamines, such as epinephrine and norepinephrine (ne), on cardiac muscle cells. matrix metalloproteinases (mmps) are the key proteases involved in degradation of the ecm in heart. | 2013 | 24116115 |
| dietary plant extracts improve immune responses and growth efficiency of pigs experimentally infected with porcine reproductive and respiratory syndrome virus. | a study was conducted to evaluate the effects of 3 different plant extracts on growth performance and immune responses of weaned pigs experimentally infected with porcine reproductive and respiratory syndrome virus (prrsv). a total of 64 weaned pigs (7.8 ± 0.3 kg bw), free of prrsv, were randomly allotted to 1 of 8 treatments in a 2 × 4 factorial arrangement with a randomized complete block design. pigs were blocked by initial bw. sex and ancestry were equalized across treatments. the first fact ... | 2013 | 24126276 |
| curcumin decreases oleic acid-induced lipid accumulation via ampk phosphorylation in hepatocarcinoma cells. | non-alcoholic fatty liver disease (nafld) is one of the most common metabolic syndromes and is characterized by the accumulation of hepatic triglycerides (tg), which result from an imbalance between uptake, synthesis, export, and oxidation of fatty acids. curcumin is a polyphenol derived from the herbal remedy and dietary spice turmeric, was found to prevent obesity and diabetes in mouse models. however, a hypolipidemic effect of curcumin in oleic acid- induced hepatocarcinoma cells has not been ... | 2013 | 24142602 |