Publications

intrathecal chemotherapy: brain tissue profiles after ventriculocisternal perfusion.	ventriculocisternal perfusions with five isotopically labeled drugs were performed in the rhesus monkey and the resultant tissue diffusion concentration profiles in caudate nucleus were analyzed. the periventricular distribution space with respect to perfusate concentration was measured and expressed as microliters per 100 mg wet weight: hydroxyurea = 56; methotrexate = 27; thiotepa = 28; 1,3-bis(2-chloroethyl)-1-nitrosourea (bcnu) = 64 and cytosine arabinoside greater than 170. the apparent dif ...	1975	810575
functional properties of ganglion cells of the rhesus monkey retina.	three general classes of cells were identified in a sample of 460 cells recorded from all areas of the retina subserving the central 40 degrees of vision in the rhesus monkey. 2. one class (colour-opponent) had sustained colour-opponent responses and concentrically organized receptive fields, in which usually one cone mechanism mediated the centre response and one or two different cone mechanisms mediated the antagonistic surround. a few cells of this class had non-concentric (co-extensive) rece ...	1975	810576
trichromatic colour opponency in ganglion cells of the rhesus monkey retina.	two hundred and eleven colour-opponent ganglion cells were studied in the central 10 degrees of the retina of the rhesus monkey, to determine the inputs which they were receiving from different cone mechanisms. spectral-sensitivity measurements in the presence of neutral and coloured back-grounds showed that 24% of these cells appeared to receive input from all three cone mechanisms. 2. in 3% of the cells, the red-sensitive cone mechanism opposed the blue- and green-sensitive ones. in 18% of the ...	1975	810577
concealed colour opponency in ganglion cells of the rhesus monkey retina.	criteria for distinguishing colour-opponent from spectrally non-opponent cells and identifying colour-opponent subtypes on the basis of the cone inputs they receive, have been examined in ganglion cells of the macaque retina using threshold and suprathreshold stimuli, with and without chromatic adaptation. 2. criteria based on suprathreshold responses were found to be insufficient for distinguishing between opponent and non-opponent cells in one-third of the sample. criteria based on a 560 nm ne ...	1975	810578
a perspective of simian tuberculosis in the united states-1972.	despite the availability of effective control measures, simian tuberculosis continues to be a major colony management problem. in 1972, 909 cases of simian tuberculosis were reported to the center for disease control. most of the cases (838) were in rhesus monkeys (macaca mulatta). the attack rate was higher for animals conditioned by commercial importers prior to sale (6.6%) than for animals received shortly after importation without conditioning (1.2%) . failure to apply control measures effec ...	1975	810589
central noradrenergic regulation of cerebral blood flow and vascular permeability.	anatomical studies employing the immunofluorescence localization of dopamine-beta-hydroxylase [= dopamine beta-monooxygenase; 3,4-dihydroxyphenylethylamine, ascorbate:oxygen oxidoreductase (beta-hydroxylating); ec 1.14.17.1] have demonstrated in brain central noradrenergic nerve fibers on small intraparenchymal blood vessels, including capillaries. this system is distinct from the peripheral noradrenergic system inervating the large extraparenchymal blood vessels. from these anatomical findings ...	1975	810805
lysosomal dysfunction in colonic submucosal macrophages of rhesus monkeys caused by degraded iota carrageenan.	administration of a degraded iota carrageenan in drinking water to rhesus monkeys resulted in storage of carrageenan in colonic submucosal macrophage lysosomes that persisted even after prolonged recovery. this storage was accompanied by alterations in lysosomal function (appearance of cytoplasmic acid phosphatase, failure of hrp laden endocytic vesicles to fuse with the carrageenan laden lysosomes). macrophage necrosis and leukocytic infiltration were also observed. administration of a native ( ...	1975	810808
fenfluramine and n-ethyl amphetamine: comparison of the reinforcing and rate-decreasing actions in the rhesus monkey.	n-ethyl amphetamine hcl (nea) and fenfluramine hcl (meta-trifluoromethyl n-ethyl amphetamine) were evaluated as reinforcers in rhesus monkeys that had been previously trained to press a lever using food presentations and cocaine hcl injections as reinforcers. each daily session consisted of episodic opportunities to obtain reinforcers under a fixed-ratio schedule of 30. a drug period was interpolated between two periods in which lever-press responding was maintained by food presentations. compar ...	1975	810821
dyskinesias elicited by methamphetamine: susceptibility of former methadone-consuming monkeys.	rhesus monkeys with a history of drinking methadone but currently drug-free and control monkeys with no drug history were injected with methamphetamine hydrochloride (2 to 5 milligrams per kilogram of body weight). in six of seven monkeys which had consumed methadone the lowest dose immediately elicited pronounced oral dyskinesias virtually identical to those of human tardive dyskinesia. the control monkeys did not exhibit oral dyskinesias even after prolonged treatment with the highest dose. th ...	1975	810889
simian plasmodium knowlesi malaria: studies of coagulation and pathology.	uniformly fatal simian malaria was induced in ten rhesus monkeys by injection of plasmodium knowlesi. the results of serial studies of platelet and blood coagulation factor levels suggested the occurrence of intravascular coagulation during the last 48 hours of the disease, concurrent with a marked fall in hematocrit levels. fibrinogen survival was slightly decreased (two animals), but quantitative fibrinogen levels were elevated. pathologic studies revealed only minimal evidence of fibrin depos ...	1975	811125
the counting and sizing of spermatozoa from ten animal species using a coulter counter.	accurately calibrated coulter counters, models zb industrial and f, were used to count and size spermatozoa before and after zaponin treatment which lyses accompanying debris, droplets and peripheral sperm cytoplasm. sperm specimens from the cauda epididymis of the rabbit, guinea pig, hamster, rat and mouse were without accompanying particles and could be sized without zaponin treatment. the large acrosome cap of the guinea pig swelled rapidly when the spermatozoa were released into an isotonic ...	1975	811131
cardiorespiratory effects of high positive end-expiratory pressure.	five healthy rhesus monkeys were ventilated with intermittent mandatory ventilation and 20 torr positive end-expiratory pressure (peep) for 8 hours. peep was increased to 25 torr and the monkeys were ventilated for 4 more hours. lactated ringer's solution and human salt-poor albumin were used to expand plasma and extracellular fluid volume throughout the entire period of study. homologous blood was administered to maintain hematocrit at control levels and maintenance fluids were infused to maint ...	1975	811132
adaptive changes in the face of the macaca mulatta monkey following orthopedic opening of the midpalatal suture.	the classical effects of lateral orthopedic stress on the midpalatal suture were confirmed in this study conducted on ten female macaca mulatta monkeys in the mixed dentitional period. the suture was opened with consequent expansion of the maxillary arch, of the intranasal space, and of the palatal vault. there was marked buccal displacement of the upper posterior teeth together with a definite broadening of the entire midface. modest relapse of maxillary expansion and of palatal depth occurred ...	1975	811136
glaucoma-induced changes in the ciliary ganglion.	changes in ciliary ganglion cells are described after the experimental induction of glaucoma in rhesus monkeys. they appear within 12 hours in the form of peripheral displacement or extrusion of the cell nucleus and loss of nissl granules.	1975	811251
modification of the response to separation in the infant rhesus macaque through manipulation of the environment.	rhesus mother-infant pairs were housed in a playpen apparatus beginning just before the birth of four male infants. the infants were separated from their mothers four times beginning at a mean age of 218 days. in type a separations (i and iv) the infants were removed and housed away from their familiar environment in a protected setting; in type b separations (ii and iii) the infants remained in the familiar setting and mothers were removed. one pair was separated every 2 weeks for 6 days; for a ...	1975	811270
relationship between growth of brain and skull of macaca mulatta and its importance for the stereotaxic technique.	an analysis of the brain weight of 196 rhesus monkeys and lateral x-rays of 91 more was made to determine and correct the effect of growth and development on sterotaxic variability. a comparison of body weight to brain weight shows that the brain grows rapidly initially in a linear relationship with body weight and can increase in weight even into adulthood, with a significant amount of variability found throughout its development. the examination of the cranial base and sterotaxic reference poi ...	1975	811323
a comparative study of deep avian foveas.	the foveas of nine avian species, initially selected for the presence of a deep fovea and representing a wide range of eye sizes and ecological habits, were studied with quantitative light microscope techniques. considerable variation was observed in the location and configuration of the avian foveas, although they appeared to be 'convexiclivate' in shape when compared with the fovea of the rhesus monkey. comparisons of foveal cell densities (receptor nuclei and ganglion cells) across species sh ...	1975	811324
hypothalamic supraoptic neurones: rates and patterns of action potential firing during water deprivation in the unanaesthetized monkey.	extracellularly recorded action potentials were obtained from hypothalamic supraoptic neurones in unanaesthetized rhesus monkeys. rates and patterns of firing were studied during an initial control period, during 5 successive days of water deprivation and during 4 further days when drinking water was again available. during water deprivation, plasma osmolarity increased progressively from about 300 mosmoles/kg to about 340 mosmoles/kg; control values were again reached after 3 days of rehydratio ...	1975	811325
autoradiographic evidence for a topographically organized projection from the striate cortex to the lateral geniculate nucleus in the rhesus monkey (macaca mulatta).		1975	811326
single cell activity in the auditory cortex of the unanesthetized, behaving monkey: correlation with stimulus controlled behavior.	the neural activity of 60 cells in the auditory cortices of two rhesus monkeys was examined in relation to systematic variations in cued reinforcement conditions. subjects were trained on a variant of the auditory reaction time (rt) task. in the final behavioral paradigm monkeys were rewarded for rapid key releases to all tonal stimuli in one reinforcement condition (frequency irrelevant = fi), while in the other stimulus-cued condition (frequency discrimination = fd) releases to certain tonal t ...	1975	811328
effective body water half-life and total body water in rhesus and cynomolgus monkeys.	although body water content and effective water half-life have been determined in several mammalian species, including man, these measurements are not available for sub-human primates to our knowledge. values were therefore determined in a group of rhesus and cynomolgus monkeys. a fairly wide range of water half-life values was found in each of the two species between animals, but there was little variation within animals who had more than one determination over the course of 1 year. mean values ...	1975	811339
studies on gonococcal infection. ii. attachment and fate of gonococci in tissue-culture cells.	neisseria gonorrhoeae 188, type 1, was cultured with monolayers of rhesus monkey kidney (re2) cells. attachment of gonococci to re2 cells occurred from about 2 h after inoculation and appeared maximal by 6 h when stained with crystal violet solution and examined under a light microscope. preferential attachment of gonococci to the perinuclear region of tissue cells could not be demonstrated. enumeration of the colony-forming units revealed that gonococci became rapidly attached to re2 cells, inc ...	1975	811342
gonococcal growth factors in tissue cultures.	growth of neisseria gonorrhoeae in the presence of rhesus monkey kidney (re2) cells containing eagle's minimal essential medium (mem) 'conditioned' by 18-20 h of contact with re2 cells began 3-4 h after inoculation and by 16-20 h had reached a maximum. when 'conditioned' medium (cm) was removed from the tissue cells and replaced with fresh medium a 5-6 h lag period occurred before multiplication of gonococci began and by 16 h growth was also near a maximum. cm removed from tissue cells supported ...	1975	811344
in vivo determination of cerebral blood volume with radioactive oxygen-15 in the monkey.	a method for the in vivo determination of cerebral blood volume was tested in 15 adult rhesus monkeys. the technique utilized external residue detection and required the serial measurement of two mean transit times, namely, that of an intravascular tracer, c15o-hemoglobin, and that of a diffusible tracer, h215o. in computing the mean transit time for the intravascular tracer, the conventional hamilton extrapolation of the downslope of the recording obtained for the washout of the tracer from the ...	1975	811413
projections of the medial pulvinar to orbital cortex and frontal eye fields in the rhesus monkey (macaca mulatta).		1975	811490
the concentration of ascorbic acid in the posterior and anterior chambers of the rhesus monkey (macaca mulatta).	the ascorbic acid concentration in the posterior and anterior chambers of the rhesus monkey (macaca mulatta) eye was determined, and found to be significantly higher in the posterior chamber. monkeys anesthetized with pentobarbital sodium had a higher posterior chamber ascorbic acid concentration than monkeys sedated with phencyclidine. the ascorbic acid diffusion coefficient, calculated from the posterior and anterior chamber data, was 0.0012 min.-1 for monkeys given phencyclidine and 0.0010 mi ...	1975	811583
chromatographic methods for the analysis of hexachlorobenzene and possible metabolites in monkey fecal samples.	the separation and identification of hexachlorobenzene (hcb), pentachlorobenzene (qcb), and pentachlorophenol (pcp) by thin layer, high-pressure liquid, and gas chromatography are reported. satisfactory results were obtained with reverse phase thin layer and high-pressure liquid chromatography. the 2 gas chromatographic columns tested gave adequate separation of hcb and qcb. a pcp methylation process using dimethyl sulfate was attempted. procedures are presented for extraction, cleanup, separati ...	1975	811638
effects of taurodihydrofusidate, a bile salt analogue, on bile formation and biliary lipid secretion in the rhesus monkey.	bile salts play a major role in bile formation and biliary lipid secretion. sodium taurodihydrofusidate (tdhf), a derivative of the antibiotic fusidic acid, closely resembles bile salts in terms of structure, micellar characteristics, and capacity ot solubilize otherwise insolbule lipids. we have therefore studied the biliary secretion of this bile salt analogue and its influence on bile formation and biliary lipid secretion in primates. alert, unanesthetized female rhesus monkeys prepared with ...	1975	811689
effects of one-stage and serial ablations of the middle third of sulcus principalis on delayed alternation performance in monkeys.	recovery of a spatial delayed alternation habit following partial frontal lesions was investigated in mature rhesus monkeys. all animals subjected to serial ablation of the middle third of sulcus principalis were found to be capable of reacquiring preoperative levels of performance on the task. however, one-stage removal of the mid-principalis region resulted in both more severe and more protracted impairments than were evident after serial surgery. these results in conjunction with previous fin ...	1975	811693
isolation of poxvirus from an african rodent.	a poxvirus was isolated from a wild gerbil (tatera kempii) caught in northern dahomey, africa at the time of an epidemic of human smallpox. electron microscopic appearance and serologic reactions placed it in the vaccinia subgroup of poxviruses. the isolate differed from ectromelia, rabbitpox, vaccinia, monkeypox, and cowpox viruses in pock morphology on chorioallantoic membrane, ceiling temperature, relative innocuity for mice, and cytopathic effect in tissue culture. like variola minor virus, ...	1975	811713
clindamycin concentrations in the central nervous system of primates before and after head trauma.	the authors measured levels of clindamycin, a drug well established as useful in the treatment of various soft-tissue and parenchymal bacterial infections, in serum, cerebrospinal fluid, and brain tissue of 14 rhesus monkeys. penetration into brain tissue was erratic and concentrations detected were not significant. cerebrospinal fluid levels, however, averaged 20.5% of paired serum concentrations and were higher than concentrations needed to inhibit most gram-positive bacteria. further studies ...	1975	811766
spinal cord blood flow as affected by changes in systemic arterial blood pressure.	the authors used the hydrogen clearance method to measure focal spinal cord blood flow (scbf) in the rhesus monkey over a wide range of mean arterial blood pressures (map) in an attempt to test the hypothesis of autoregulation. the map was either lowered by bleeding or raised by the intravenous infusion of norepinephrine or angiotensin. the scbf remained constant and in the normal range with an map of 50 to 135 mm hg, indicating the presence of autoregulation. below 50 mm hg, scbf fell passively ...	1976	811767
monkey brain damage from radiation in the therapeutic range.	twelve macaca mulatta monkeys received 200 rads of supervoltage radiation to the whole brain per day, 5 days a week. the course in 4 monkeys was 4 weeks for a total dose of 4000 rads; in 4 monkeys, 6 weeks for 6000 rads; and in 4 monkeys, 8 weeks for 8000 rads. four unirradiated monkeys served as controls. one from each group, sacrificed at 6 and 12 months from start of irradiation, are reported here. the results from 4000 rads were negligible; those from 8000 rads, profound, with gross brain de ...	1976	811769
recovery of schistosomula in the skin of rhesus monkeys immunized with cercariae of schistosoma japonicum exposed to high dose of x-irradiation.		1975	811784
barbiturate-reinforced responding in rhesus monkeys: comparisons of drugs with different durations of action.	the rate and pattern of pressing a lever was studied in rhesus monkeys under conditions where each press led to the intravenous injection of a barbiturate or of saline. the reinforcing effect of the barbiturate was indicated by higher rates of responding on the lever that delivered drug than on the lever that did not and by lower rates of responding when saline was delivered instead of the barbiturate. responding increased and was maintained by the following ranges of dose/injection: barbital (2 ...	1975	811787
mechanism of immunity of schistosomiasis: histopathologic study of lesions elicited in rhesus monkeys during immunizations and challenge with cercariae of schistosoma japonicum.		1975	811795
intragastric self-administration of psychoactive drugs by the rhesus monkey.		1975	811941
visual attention and inferotemporal cortex in rhesus monkeys.		1975	812002
further comments on the ascorbic acid requirement.	recommended daily allowances (us rda) of the food and drug administration for ascorbic acid are higher than recommended dietary allowances (set by the food and nutrition board) for adults. there is a 6-fold margin between the requirement to prevent scurvy and the us rda. the high requirement reported for the rhesus monkey may be needed to compensate for oxidative catabolism of ascorbic acid in this species. the rate of production of ascorbic acid, in mammals that synthesize it has been listed as ...	1975	812090
primate drinking system as defined by electrical stimulation of the brain (esb).	four rhesus monkeys were examined by esb for drinking sites in structures that had been previously demonstrated to support drinking behavior. three yielded a significantly greater proportion of drinking sites than expected from the earlier study, and one yielded significantly less. as the exploration proceeded, the proportion of sites yielding drinking greatly increased in the drinkers and decreased in the nondrinker, and the ratio of stimulus-bound to nonstimulus-bound drinking sites increased ...	1975	812128
asymmetrical cross-tolerance between morphine and scopolamine induced antinociception in the primate: differential sites of action.	two experiments explored the role of the cholinergic system in mediating morphine induced analgesia in the rhesus monkey. experiment 1 tested for cross-tolerance between two antinociceptive compounds, morphine and scopolamine, using the shock titration technqiue. tolerance to morphine attentuated the response to scopolamine but tolerance to scopolamine had no effect on morphine induced antinociception. in experiment 2, the shock threshold was not modified by injections of scopolamine or arecolin ...	1975	812134
dialyzable transfer factor.	dialyzable transfer factor, obtained from human peripheral blood leukocytes and first described by lawrence, is being used in attempts to rectify defects in the cellular immune systems of patients with basic immunodeficiencies, chronic infectious diseases, and neoplastic diseases. current knowledge of the chemical character of, assays for, and functional activities of transfer factor are briefly reviewed. an experimental animal model for dialyzable transfer factor involving the rhesus monkey (ma ...	1975	812183
studies on pivka-x.	the incorporation of 14c-glucosamine and 3h-leucine into pivka-x and factor x has been studied in macaca mulatta by means of a monospecific precipitating antiserum. no difference in the incorporation into pivka-x and factor x was found. the half-lives of pivka-x and factor x were similar (about 30-35 h and 27-31 h respectively) indicating that the vitamin k-induced modifications did not alter the survival of protein. a russell's-viper venom/cephalin test system for factor x was more sensitive to ...	1975	812196
platelet aggregates in hypercholesterolemic rhesus monkeys.		1975	812202
timing of major ontogenetic events in the visual cortex of the rhesus monkey.	the place and time of origin, the migration and eventual disposition of neurons of the monkey visual cortex were studied by autoradiography in animals killed at various intervals after 3h-thymidine pulse labeling at embryonic (e) and early postnatal (p) stages. all neurons destined for the visual cortex are generated during about a 2-month period between e45 and e102. neuron position in the cortical laminae correlates systematically with time of cell origin; neurons destined for deeper cortical ...	1975	812226
age, sex, and experience as related to the neural basis of cognitive development.	studies of rhesus monkeys raised from infancy without portions of the central nervous systems provide evidence regarding the timing of functional maturity of specific regions. some findings have been presented which show that deficits following lesions of specific cortical areas emerge at that age when abilities dependent upon the cortical area in question take on adult form in unoperated monkeys. however, age is but a convenient abstraction for conditions that vary over time. one such condition ...	1975	812229
effects of intense visible radiation on the increment-threshold spectral sensitivity of the rhesus monkey eye.		1975	812257
miniature eye movements of fixation in rhesus monkey.		1975	812258
[the effect of depot contraceptive agents on the ovary in rhesus monkeys].		1975	812316
the effects of tolbutamide on the development of atherosclerosis in rhesus monkeys fed an average american table-prepared diet.		1975	812341
presence of multiple centrioles in a rhesus macaque oocyte matured in vitro.	this report demonstrates for the first time the presence of centrioles in a rhesus macaque oocyte which had attained meiotic maturation in culture. the exceptional presence of centrioles in this oocyte was associated with anomalous patterns of chromosomal and spindle organization.	1975	812353
3h2o volume and exchange in uterine cavity of monkeys.	a technique was developed to measure water exchange in the endometrical canal (uterine cavity). this type of determination should provide information necessary to understanding intrauterine pharmacokinetics. in the study described, measurements were performed on one cynomologus and four rhesus monkeys. endometrial fluid in the uterine cavity was replaced with a 3h2o solution of known specific radioactivity (dpm/ml). radioactivity remaining in the cavity at measured intervals of approximately 0.5 ...	1975	812366
effects of chlorpromazine on the vertical chamber syndrome in rhesus monkeys.	in an attempt at social rehabilitation, chlorporomazine was given to three groups of rhesus monkeys that had been confined to the vertical chambers apparatus early in their development. previous studies have shown that such periods of deprivation produce severe deficits in social behavior. there were no substantial beneficial effects of chlorpromazine treatment; however, there was a notable amount of spontaneous improvement seen in all three groups. we discuss these data in terms of their implic ...	1975	812449
quantitative observation of behavior in free-ranging macaca mulatta: methodology and aggression.		1975	812469
[experimental argon-laser trabeculo-puncture in rhesus monkeys].		1975	812471
hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia.	inbred carworth farms nelson (cfn) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, ii, v, vii, viii, and x than did controls. conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors ii, v, vii, x and xii and of blood platelets than did controls. a loop-shaped polyethylene cannula was inserted into the aorta to assess ...	1976	812575
cortical blindness after overlapping retinal-striate lesions: a limit to plasticity in the central visual system.	lesions in cats, rats, and monkeys that spare more than 2% of the optic tract or visual cortex cause trivial deficits on most measures of vision. overlap in the topography of the visual system may allow the spared remnant to 'see' a wider field of vision than the physiological map predicts. we tested whether monkeys left with only the lower retinal-field portion of their striate map could see with information coming from the upper half of the retina. in 6 rhesus monkeys the ganglion fibers exiti ...	1976	812586
cis-dichlorodiammineplatinum (ii) (nsc-119875): hearing loss and other toxic effects in rhesus monkeys.	ototoxicity and general toxicity of cis-dichlorodiammineplatinum (ii), a compound with antitumor activity, were evaluated in four rhesus monkeys. audiometry was performed with shock avoidance to donditioned stimuli of pure tones at frequencies from 0.25 to 18 khz. histopathologic lesions of the inner ear were identified with phase-contrast microscopy of surface preparations from the organ of corti. the monkeys were also submitted to physical examinations, hematologic and blood chemical determina ...	1975	812603
preclinical studies with triazinate (nsc-139105), an antifolate drug, in beagle dogs and rhesus monkeys.	the effects of the intravenous administration of triazinate by single and multiple injections were studied in beagle dogs and rhesus monkeys. in dogs, dose levels ranging from 0.3125 to 40 mg/kg were given either as single doses daily for 5 days, or once weekly for 6 weeks. the 5-day regimen was also studied in monkeys with dose levels from 2.5 to 40 mg/kg/day. prominent drug-related and drug-dependent effects which appeared in both species were piloerection, muscular weakness, and respiratory d ...	1975	812604
the motor nerve supply of the velopharyngeal muscles.	the present study attempted to clarify the motor nerve supply of the velopharyngeal muscles. experiments were carried out on 20 anesthetized rhesus monkeys. evoked emg responses of the levator veli palatini, uvula, and superior constrictor pharyngeus muscles, which seem to contribute to velopharyngeal closure, were analyzed by stimulating the cranial nerves within the skull. results were as follows: 1. muscle action potentials (m-waves) from the selected muscles could be recognized on stimulatin ...	1976	812618
treatment of postpartum rhesus monkeys with progestogen: appearance in milk and effects on lactation.		1975	812634
metabolic, endocrine and organ functions in monkeys immunized with pr-beta-hcg-tt vaccine.	the vaccine pr-beta-hcg-tt was injected into 12 rhesus monkeys; 10 monkeys were used as controls. at 3-13 months after immunization, blood and urine samples were examined. hemoglobulin and packed call volumes were unaltered. total leukocyte counts were similar but the percentage of neutrophils was reduced in immunized animals. serum bilirubin, alkaline phosphastase, glutamic oxaloacetic, and glutamic pyruvic transaminases, true and pseudocholinesterases, lactic acid dehydrogenase and its is ...	1976	812636
mechanisms of retinal damage resulting from the exposure of rhesus monkeys to ultrashort laser pulses.		1975	812713
transmission of hepatitis b to the rhesus monkey.	the rhesus monkey does provide a suitable laboratory animal model for studying hepatitis b virus and for investigating various aspects of interaction between this infectious agent and the host. this species of non-human primate, however, offers a less sensitive animal model for hepatitis b infection than the chimpanzee.	1975	812744
hepatic toxicity in the rhesus monkey treated with chenodeoxycholic acid for 6 months: biochemical and ultrastructural studies.	the long term administration of chenodeoxycholic acid in man has to be regarded with caution because chenodeoxycholic acid has caused liver damage in various species of animals, including primates. to study the effect of three doses of chenodeoxycholic acid (10, 40, and 100 mg per kg per day) on hepatic function and morphology, biliary bile acid composition and the reversibility of changes were investigated in 22 rhesus monkeys. after 6 months of treatment with 40 and 100 mg per kg per day, bile ...	1976	812760
evaluation ofprimary blood monocyte and bone marrow cell culture for the isolation of rickettsia rickettsii.	rickettsia rickettsii was isolated from experimentally infected guinea pigs by culture of blood monocytes and bone marrow cells, and from experimentally infected rhesus monkeys by blood monocyte culture. rickettsiae were identified in monocyte-macrophage monolayers stained by giménez or flourescent antibody techniques. a total of 78 culture attempts were made from 20 guinea pigs and 16 monkeys. the success of isolation of r. rickettsii in culture was positively correlated with the numbers of ric ...	1975	812828
the effect of cholinergic and anticholinergic agents on the primate model of allergic asthma.	rhesus monkeys with reagin-mediated, immediate-type respiratory responses to ascaris antigen were used for comparison with the type of responses that occur from certain pharmacologic agents. carbacholine produces a respiratory response that is the same type as an antigen-induced respiratory response and will sensitize an animal's airway so that a dose of antigen not reactive alone will stimulate a response. antigen and histamine will sensitize the airway so that a subthreshold dose of carbacholi ...	1976	812931
diastolic and systolic blood pressure measurements in monkeys determined by a noninvasive tail-cuff technique.	a noninvasive method to determine systolic, diastolic, and mean blood pressure values in rhesus monkeys is described and evaluated. simultaneous measurements of abdonimal aortic and tail-cuff pressures were compared for unanesthetized, anesthetized, hemorrhaged, and methoxamine-treated animals. data indicated that correlation between direct and indirect methods were highly significant (r greater than or equal to 0.94); the mean differences found between the two measurements were less than or equ ...	1976	812932
studies on plasma corticosteroids in the rhesus monkey (macaca mulatta).	the physiological regulation of the plasma corticosteroid concentration, measured by competitive protein-binding, was studied in female rhesus monkeys (m. mulatta) sedated with phencyclidine hydrochloride. morning basal levels of plasma corticosteroids were found to be in the range 8-0-25-2 mug/100 ml, which is lower than that previously reported in this species. a circadian rhythm in plasma cortisol concentration was demonstrated. prolonged sedation with phencyclidine was associated with a grad ...	1975	812935
disposition of diethylstilbestrol in the rhesus monkey.		1975	812978
effects of morphine and narcotic antagonists on avoidance behavior of the squirrel monkey.	the effects of morphine, cyclazocine and nalorphine were evaluated on the continuous avoidance behavior of the squirrel monkey with schedule parameters similar to those used in previous studies on the rat. with this schedule, a lever-pressing response postponed or terminated the delivery of an electric shock to the monkey's tail. dose-response curves were determined for each drug administered alone and in combination with 1.0 mg/kg of naloxone. in the 1st hour of a 4-hour session, avoidance resp ...	1976	812979
proceedings: the effect of cooling nucleus interpositus of the cerebellum in rhesus monkeys on the tracking of a visual target.		1975	812983
prefrontal unit activity during delayed-response and delayed-alternation performances.	in order to examine whether or not the single unit activity of the dorsolateral prefrontal cortex of the rhesus monkey activated during delayed-response task is involved in a delayed-alternation task, the same prefrontal single unit activities were recorded extracellularly using tungsten electrodes while the monkey was performing the two tasks alternatively. visual signals were given to two different locations (left and right) as visual cues and response cues. a total of 95 units were recorded. ...	1975	813043
fetal brain injury after maternal carbon monoxide intoxication. clinical and neuropathologic aspects.	in a model of brain damage in the rhesus monkey fetus, carbon monoxide inhalation by the mother was used to produce graded fetal hypoxia. four fetuses with aterial oxygen contents of 2.1 to 2.4 ml per 100 ml during the most severe insult hour appeared neurologically normal, and their brains contained no lesions. a single animal with an intermediate degree of hypoxia was moderately abnormal; its brain showed extensive necrosis of the basal ganglia. four fetuses with arterial oxygen contents of 1. ...	1976	813158
a method of quantitating injury inflicted in acute spinal cord studies.	spinal cord trauma was induced in cats and rhesus monkeys using an improved method which allows for accurate quantitation of the force delivered. the materials and methods described consist of a weight which is dropped down a centre shaft on to a strain gauge arch assembly which transfers the force to a teflon impounder resting on the exposed dura of the cord. the force transferred from the weight to the impounder is recorded by the strain gauge and thr force curve can be displayed on a storage ...	1975	813173
reversibility of fatty streaks in rhesus monkeys.		1976	813208
coronary artery fine structure in rhesus monkeys: nonatherosclerotic intimal thickening.		1976	813209
blood-aqueous barrier can be circumvented by lowering intraocular pressure.	rhesus monkeys were injected intravenously with hypertonic urea (9 ml/kg body weight of 30% urea in 10% invert sugar) and the intraocular pressure was measured with an applamatic tonometer. when this pressure reached its minimum (20% of the normal value) horseradish peroxidase (molecular weight 40,000; radius of an equivalent hydrodynamic sphere about 2.5 nm; 0.5 g/kg body weight), was injected intravenously. twenty minutes following peroxidase administration, either aqueous humor was sampled fr ...	1976	813231
retention of functional tolerance to ethanol in rhesus monkeys (macaca mulatta).	tolerance to ethanol (3 g/kg 90 min prior to testing) was assessed in a group of 4 rhesus monkeys in which tolerance development had been observed using the same behavioral task one year prior to the present study. although some decrements in performance on a two-choice discrimination reversal learning task were observed, these changes were transient and statistically insignificant. results indicate that functional tolerance persisted throughout a one year abstinence period.	1975	813240
maternal estrogen and progesterone levels after hypophysectomy in early pregnancy and in term fetuses or newborn monkeys.	pregnant rhesus monkeys (macaca mulatta) were hypophysectomized at 8-10 weeks gestation to determine effects on plasma levels of estrone (e1), estradiol-17beta (e2), and progesterone (p). the first group of monkeys was subsequently fetectomized at 107-114 days. after hypophysectomy there was an initial decrease in maternal peripheral plasma e2 followed by a rise to preoperative levels within 4-5 weeks. plasma levels of e1 and p were not markedly altered. after fetectomy, peripheral estrogen conc ...	1975	813337
uterine contractility and regional blood flow responses to oxytocin and prostaglandin e2 in pregnant rhesus monkeys.		1974	813338
comparative effects of hyperosmolar urea administered by intra-amniotic, intravenous, and intraperitoneal routes in rhesus monkeys.	hypertonic urea solutions (58 per cent weight/volume) were injected rapidly into ten anesthetized rhesus monkeys at a dose of approximately 2 gm. per kilogram by the intravenous, intraperitoneal, or intra-amniotic routes. an additional monkey received an intra-amniotic dose of 12.5 gm. per kilogram. a tracer dose 14c-urea was included for measuring absorption and elimination. the following parameters were monitored before and for four hours after urea injection: arterial and cerebrospinal fluid ...	1976	813523
pharmacokinetics of intra-amniotically administered hyperosmolar urea in rhesus monkeys.	three rhesus monkeys in midgestation were injected intra-amniotically with hyperosmolar 14c-urea (58 per cent weight/volume, 2.3 gm. per kilogram, 25 muc) and the concentration of 14c-urea measured serially for 24 hours in amniotic fluid, maternal serum, and maternal urine. the volume of the amniotic space was measured by isotope dilution of 99mtc-albumin. the experimental values were fitted to a three-compartment mathematical model with the aid of a digital computer program for nonlinear data. ...	1976	813524
the relationship of tooth size to body size in a population of rhesus monkeys (macaca mulatta).	tooth areas correlate significantly with long bone measurements in a skeletal population of rhesus monkeys from cayo santiago. correlations are relatively large for the troop as a whole, as well as for males and females separately. femur and humerus length measurements show the higheres correlations with tooth size.	1975	813527
growth of the maxillary complex in the rhesus monkey (macaca mulatta).	the growth of the maxillary complex of 36 rhesus monkeys (macaca mulatta) was analyzed quantitatively and qualitatively during four defined stages of postnatal development (i.e., infant, juvenile, adolescent, young adult). at each stage, growth was observed during a 24 week period. since some animals were observed during two successive stages of development, 47 periods of growth were studied. the incremental growth data were collected by superimposing serial cephalograms on cranial base implants ...	1976	813530
pressure effects on the endothelium of the trabecular wall of schlemm's canal: a study by scanning electron microscopy.	the scanning electron microscope was used to compare the appearances of the endothelial monolayer of the trabecular wall of schlemm's canal in the rhesus monkey after exposure to intracameral pressures of 8, 15 and 22 mm hg for one hour. over this pressure range, the bulges in the spindle-shaped structures in the monolayer became rounder in shape and the number of openings on the surface was apparently greater at 22 mm hg than at 15 and 8 mm hg. a quantitative comparison between the tissue at 8 ...	1975	813538
cardiovascular effects of enflurane and halothane on the rhesus monkey.	ten rhesus monkeys were chronically instrumented to compare the cardiovascular effects of enflurane and halothane. in 17 experiments, each monkey was evaluated in the awake state and after equilibration at each of many anesthetic levels. end-expired gas concentrations were expressed in multiples of human minimum alveolar concentrations (mac) for comparison. there was a predictable dose-related decrease in heart rate, mean arterial pressure, peak left ventricular dp/dt, and the latter divided by ...	1976	813544
functional evaluation of the interposed colon as an esophageal substitute.	five rhesus monkeys and four human adults with colonic reconstruction of the esophagus have been studied by manometric, fluoroscopic and reflux tests. transit through the graft is mainly under the influence of gravity. infrequent colon contractions can be propulsive, and sequential haustral contractions give the appearance of peristalsis. the diaphragmatic hiatus and esophagocolic anastomosis are the sites of weak barriers to reflux which are readily overcome by abdominal compression and gastric ...	1976	813587
[aromatization of 3h-androstenedione in the liver and ovary of a postmenopausal rhesus monkey in vivo].		1975	813609
female rhesus sexual behavior and distance to a male partner: relation to stage of the menstrual cycle.	female rhesus monkeys were observed in standardized mating tests during successive menstrual cycles as well as in tests while separated from, but in view of, their male partners. under both conditions, behaviors of the female were noted which varied with the stages of the menstrual cycle. some of the most prominent fluctuations occurred in measures of interindividual distance. in particular, time spent near the male peaked at the time most likely for ovulation. the pattern of changes in this beh ...	1975	813615
experimental argon laser photocoagulation. i. effects on retinal nerve fiber layer.	eight rhesus monkeys were photocoagulated with varying intensities of argon laser energy to determine the effects on the retinal nerve fiber layer. photocoagulation of arterioles and venules always resulted in largely irreversible and permanent perivascular axonal destruction. photocoagulation of areas free of major vessels showed variable responses to identical dosages, ranging from minimal destruction of the outer part of the retina to full-thickness destruction involving the nerve fiber layer ...	1976	813620
thyroxine-binding globulin biosynthesis in isolated monkey hepatocytes.	thyroxine-binding globulin biosynthesis was demonstrated in hepatocytes isolated from normal adult rhesus monkeys. dispersed cells were obtained by in situ liver perfusion with collagenase, hyaluronidase and edta. conditions for optimum cell survival and incorporation of radioactive leucine into newly synthesized proteins were defined. protein synthesis, and specifically thyroxine-binding globulin synthesis, were shown to continue throughout the incubation period, while cell survival remained hi ...	1976	813766
3-methoxy-4-hydroxyphenylethyleneglycol (mhpg) transport from the spinal cord during spinal subarachnoid perfusion.	spinal subarachnoid perfusions of rhesus monkeys were performed to study the transport of 3-methoxy-4-hydroxyphenylethyleneglycol (mhpg) by the spinal cord. the perfusate contained [3h]mhpg and a reference extracellular space marker ([14c]sucrose of [14c]ethylenediaminetetraacetic acid-calcium complex). the mean (+/- s.d.) clearance of mhpg by the monkey spinal cord was 33 (+/- 4) mul/min. analysis of serial sections of spinal tissue after each perfusion facilitated determination of several basi ...	1976	813817
tissue distribution, binding properties and lesions produced by dehydroretronecine in the nonhuman primate.	four-month-old rhesus monkeys were injected with 65 mg of [3h] dehydroretronecine per kg body weight and sacrificed at 6,12 and 24 h following injection. by the 24th h 13% of the dose had been eliminated in the urine. although there were no feces, the extremely high radioactivity of the bile and intestinal contents suggested this route was a major one for the excretion of this compound. the 3h was distributed throughout the body by the 6th h with the greatest percentage being in the skin and mus ...	1976	813833
plasma neurophysin levels in monkeys: emphasis on the hypothalamic response to estrogen and ovarian events.	specific radioimmunoassays for human neurophysins released in response to estrogen (estrogen-stimulated neurophysin, esn) and nicotine (nicotine-stimulated neurophysin, nsn) have been used to measure two similar neurophysins in rhesus monkey plasma. as in the human, concentrations of rhesus monkey neurophysins in plasma were specifically produced a marked increase of plasma nsn concentrations in the monkey. estradiol benzoate administered intramuscularly consistently produced an increase in plas ...	1976	813993
some cortical projections to the parahippocampal area in the rhesus monkey.		1976	814012
reversible inhibition of ovulation in the rhesus monkey by polydimethylsiloxane subdermal capsules of megestrol acetate.	the effect of megestrol acetate in polydimethylsiloxane subcutaneous implants on menstrual cycle, ovarian function, and uterine histology of adult parous rhesus monkeys was studied. release rates of 129.6 and 64.8 mug/day inhibited ovulation and produced amenorrhea in all of the treated monkeys. the plasma progesterone level was 0 ng/ml during the initial part of the study (8 months). endometrial biopsies obtained at different times showed a suppressed endometrium. approximately 30 days after re ...	1976	814022
an experimental model of aortic coarctation in rhesus monkeys.		1975	814086
determination of body surface area in the rhesus monkey.	body surface areas (bsa) of 31 apparently normal rhesus monkeys of both sexes weighing 3.2-5.3 kg were determined by the direct skinning technique. the range of measured bsa was 1,940-3,020 cm2 (mean = 2,430 cm2). the bsa values of male and female monkeys were not significantly different. the k value, calculated as the ratio of bsa (cm2)/body wt2/3 (kg), was 969 +/- 15 (se). based on the principle of least squares for goodness of fit between the measured and calculated bsa, the best equation was ...	1976	814115
stimulation of rhesus monkey gh release: arginine vs plasma volume expansion.	plasma gh and cortisol responses were examined in unanesthetized adult male rhesus monkeys infused with approximately 30 ml (8.3 ml/kg) of arginine monohydrochloride (arg 0.5 g/kg), 0.9% saline (ns) or dextran 75 and following 15 ml infusions of acid-saline (as), or somatostatin (ghrih 30 mug/kg). none of the infusions were accompanied by gh elevations. rebound gh elevations occurred after each 30 ml infusion and after ghrih but not after 15 ml as. although the amplitude of gh responses were not ...	1976	814133