Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| symptoms and behavioral features induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in an old java monkey [macaca cynomolgus fascicularis (raffles)]. | the study concerns symptoms and behavioral characteristics induced by mptp in a 20-year-old macaca cynomolgus fascicularis, their evolution over 7 months, and the animal's response to 1-dopa treatment. the symptoms which the animal developed include those that have been described earlier in macaca mulatta and saimiri sciureus, i.e., rigidity, action tremor, postural tremor, postural flexion, hypokinesia, and bradykinesia. in addition, however, the animal developed a 3.8 hz resting tremor which i ... | 1986 | 3488798 |
| monkey interleukin 2: optimal conditions for production and partial characterization. | cynomolgus monkey spleen cells and peripheral blood lymphocytes were tested for their ability to produce interleukin 2 (il 2) upon stimulation with phytomitogens. by assessing proliferation of murine il 2-dependent cells, maximal release of il 2 activity was found in the supernatants of nonadherent cells cultured for 48 h, after stimulation with 25 micrograms/ml concanavalin a. addition of phorbol myristate acetate to the cultures resulted in enhancement of il 2 production, but there was no sign ... | 1986 | 3489679 |
| hemodynamic effects of corticotropin releasing hormone in the anesthetized cynomolgus monkey. | right atrial bolus administration of rat/human corticotropin releasing hormone (r/hcrh) at a dose of 90 micrograms/kg to anesthetized cynomolgus monkeys caused a dramatic and prolonged fall in both the peripheral vascular resistance (48% reduction) and mean systemic blood pressure (36% reduction). an associated tachycardia could be blocked with prior propranolol administration and thus was probably reflexic. a mean 43 and 37% increase in the flow of the superior mesenteric and common iliac arter ... | 1986 | 3490657 |
| transcutaneous electrical stimulation of the recurrent laryngeal nerve in monkeys. | the recurrent laryngeal nerve (rln) of four anesthetized adult macaca fascicularis monkeys was stimulated by applying current with blunt electrodes placed unilaterally and bilaterally on the intact neck skin along the tracheoesophageal groove. the stimulus consisted of 2.5- to 4.0-ma cathodal pulses, each of 1-ms duration, beginning at a frequency of 10 hz and increasing by 10-hz increments to 100 hz. unilateral stimulation from 10 to 30 hz resulted in a graded vocal cord abduction, with the max ... | 1987 | 3492955 |
| recombinant human granulocyte colony-stimulating factor. effects on hematopoiesis in normal and cyclophosphamide-treated primates. | we examined the in vivo effects of recombinant human granulocyte colony-stimulating factor (rhg-csf) in primates (cynomolgus monkeys) treated with subcutaneous doses of rhg-csf for 14-28 d. a dose-dependent increase in the peripheral white blood cells (wbc) was seen, reaching a plateau after 1 wk of rhg-csf treatment. the elevation of wbc was due to an increase in the absolute neutrophil count. these results demonstrate that rhg-csf is a potent granulopoietic growth and differentiation factor in ... | 1987 | 3494094 |
| pneumocystis infection in macaque monkeys: macaca fuscata fuscata and macaca fascicularis. | retrospective examination of lungs from 128 monkey necropsies was attempted for pneumocystis infection using special strains, including toluidine blue-o and gomori's methenamine silver nitrate. four japanese monkeys (7.7%), macaca fuscata fuscata, and one crab-eating monkey (7.7%), macaca fascicularis, were found to have pneumocystis infection. the organism was found in young and infant animals. at the time of death, one infant and two young monkeys were debilitated and/or emaciated. pneumocysti ... | 1987 | 3497397 |
| mptp, impairment of motor performance and amine accumulation in macaca fascicularis. | the selective neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) was injected (iv) into monkeys (macaca fascicularis) in two different injection regimes. with the small dose regime, one monkey was injected with 0.25 mg/kg, every other day, over a 16 day period. in the large dose regime, another monkey was injected with 0.5 mg/kg every other day, over an 8 day period. while the time required for drug delivery was varied between animals, the total dose delivered was 2 mg/kg in both ani ... | 1987 | 3498531 |
| the action of mptp on macaca fascicularis nigral neurons. | 1987 | 3502324 | |
| in vivo comparison of phenylephrine and phenylephrine oxazolidine instilled in the monkey eye. | the ocular and cardiovascular effects as well as aqueous humor and plasma concentrations of 10% phenylephrine hcl and 1% phenylephrine oxazolidine (prodrug) were compared in cynomolgus monkeys. a volume of 25 microliters of either drug was administered to one eye followed by blood pressure, pulse, and pupillary measurements at 10 min intervals up to 60 minutes. careful slit lamp examinations of the anterior segment, indirect ophthalmoscopy of the vitreous and retina, and ergs were performed at 6 ... | 1987 | 3503921 |
| sacrococcygeal dysgenesis in a crab-eating macaque. | 1986 | 3505993 | |
| normal uveal melanocytes in culture. | normal uveal melanocytes of rhesus and cynomolgus macaques can be grown in culture for 3-9 months and subcultured a few times. postnatal and adult choroidal melanocytes are terminally differentiated cells. they are melanin-containing but not actively melanin-synthesizing cells. they do not undergo cell division, nor do they incorporate tritiated thymidine, but otherwise they are metabolically active. postnatal and young adult iridial melanocytes are metabolically more active than choroidal cells ... | 1987 | 3507670 |
| effects of low-pull traction to the mandibular first molars on craniofacial growth in macaca irus monkey. | 1987 | 3509106 | |
| shear stress regulation of artery lumen diameter in experimental atherogenesis. | we studied the adaptive response of the arterial wall and intimal thickening under conditions of increased flow in an atherogenic model. blood flow was increased by construction of an arteriovenous fistula between the right iliac artery and vein in six cynomolgus monkeys fed a diet containing 2% cholesterol and 25% peanut oil. the left iliac artery served as the control. serum cholesterol increased from 135 +/- 22 mg/dl to 880 +/- 129 mg/dl during the experiment. after 6 months, blood flow in th ... | 1987 | 3509594 |
| [quantitative changes of plasma fibronectin in plasmodium knowlesi malaria]. | in order to study the variation of plasma fibronectin (fn) during malaria infection, two male monkeys (macaca fascicularis) were splenectomized and infected with plasmodium knowlesi. as parasitaemia increased fn concentration decreased gradually from 260 to 140 microgram/ml and 300 to 85 micrograms/ml for monkeys 1 and 2 respectively. the significance of this finding is discussed. | 1986 | 3517789 |
| [spontaneous diabetes mellitus in cynomolgus monkeys (macaca fascicularis)]. | glucose tolerance tests were performed with fourteen cynomolgus monkeys. they were divided into two groups with regard to the serum glucose level at the time of routine health-examination. nine of them had normal glucose level (below 123 mg/dl, the normal group) and the other five monkeys exhibited hyperglycemia (the abnormal group). fifty per cent glucose solution was administered into the saphenous vein at a dose of 4 ml/head. blood samples were taken just before and 5, 10, 20, 30, 60 and 120 ... | 1986 | 3519247 |
| mutagenicity towards salmonella typhimurium of some known genotoxic agents, activated by isolated hepatocytes of monkey (macaca fascicularis). comparison with isolated human hepatocytes. | this paper describes some striking differences between isolated human and monkey hepatocytes in their capacity to activate some known genotoxic agents into products mutagenic towards salmonella typhimurium. isolated monkey hepatocytes, in contrast to human hepatocytes, appeared to activate benzidine (bz), n-acetylbenzidine (mabz), n,n'-diacetylbenzidine (dabz), 2-aminofluorene (2-af) and 2-acetylaminofluorene (2-aaf) poorly. with monkey hepatocytes bz was slightly more mutagenic than dabz, where ... | 1986 | 3520301 |
| impairments in route negotiation through a maze after dorsolateral frontal, inferior parietal or premotor lesions in cynomolgus monkeys. | ten cynomolgus monkeys were trained to follow a fixed route through a whole-body maze consisting of 3 x 3 matrix of 9 compartments, all with interconnecting doors. two monkeys learned to use proprioceptive guidance such that they tended to produce the same sequence of movements even if they entered the maze by a different door. they were not impaired by bilateral lesions to inferior parietal cortex (area 7a/pg). the rest used non-proprioceptive guidance relying on external cues in the environmen ... | 1986 | 3524603 |
| on talc translocation from the vagina to the oviducts and beyond. | the objective of this study was to investigate whether multiple vaginal depositions of neutron-activated talc in the cynomolgus monkey result in the translocation of this material to the uterus and beyond. within a 45-day period, six monkeys received 30 applications of 125 mg neutron-activated talc, suspended in 0.3 ml physiological saline solution containing 1% carboxymethyl cellulose as a suspending agent. the suspension was deposited in the posterior vaginal fornix of the sedated monkeys. two ... | 1986 | 3525355 |
| vip terminals, axons, and neurons: distribution throughout the length of monkey and cat spinal cord. | the distribution of vasoactive intestinal polypeptide (vip) was mapped by peroxidase immunocytochemistry in the spinal cords of seven macaca fascicularis monkeys and two cats. the animals were perfusion fixed with different chemicals. those that were perfused with either a zamboni fixative or 5% acrolein had significantly greater immunoreactivity outside the sacral cords; those fixed with 4% paraformaldehyde had little in nonsacral regions. vip-like immunoreactive (vip) axons and terminals were ... | 1986 | 3525616 |
| gonadotrophin-releasing hormone (gnrh) overcomes gnrh antagonist-induced suppression of lh secretion in primates. | if the suppressive effects of gonadotrophin-releasing hormone (gnrh) antagonists on gonadotrophin secretion are mediated through gnrh-receptor occupancy alone, it should be possible to restore serum gonadotrophin levels by displacing the antagonist with exogenous gnrh. to test this hypothesis, eight adult crab-eating macaques (macaca fascicularis), weight 4.7-7.6 kg, were subjected to the following treatment regimens. a gnrh-stimulation test was performed before and 4, 12 and 24 h after a single ... | 1986 | 3525731 |
| effect of dietary carbohydrate type on lipoprotein lipase, hepatic lipase, and lecithin:cholesterol acyltransferase activities in cynomolgus monkeys. | the effects of dietary sucrose and starch with and without exogenous cholesterol on postheparin plasma lipoprotein lipase (phla) and hepatic lipase (hla) were studied in cynomolgus monkeys. serum triglyceride levels were higher in sucrose-fed animals than starch and exogenous cholesterol lowered serum triglyceride levels when added to sucrose diet but not starch diets. sucrose markedly increased insulin levels, more so than starch; however, dietary cholesterol lowered insulin levels in sucrose d ... | 1986 | 3527235 |
| autogenous dermal grafts for repair of temporomandibular joint disc perforations. | in five macaca fascicularis monkeys bilateral 5-mm perforations of the intra-articular disc were followed by unilateral repair with autogenous dermal grafts. the monkeys were killed at three, six, 12, 24, and 36 weeks after surgery. the temporomandibular joints (tmjs) were removed en bloc, decalcified, and sectioned in the sagittal plane for histologic examination. all of the control untreated disc perforations, with the exception of one, failed to heal. with all of the grafted disc perforations ... | 1986 | 3531442 |
| design and synthesis of a potent and specific renin inhibitor with a prolonged duration of action in vivo. | a structure-activity analysis of peptides containing backbone c alpha-methyl and n alpha-methyl modifications led to the discovery of potent renin inhibitors with high metabolic stability. in vitro, boc-pro-phe-n alpha-mehis-leu psi-[chohch2]val-ile-amp (xii) is a potent inhibitor of human plasma renin with ic50 of 0.26 nm. it is a much weaker inhibitor of other aspartic proteases such as porcine pepsin or bovine cathepsin d (ic50 = 6 microm). it was shown not to be degraded by a rat liver homog ... | 1986 | 3531518 |
| hormonal and cardiovascular effects of losulazine hydrochloride in relation to sodium balance in nonhuman primates. | losulazine hydrochloride, a peripheral norepinephrine-depleting agent, was studied in conscious sodium-replete and sodium depleted cynomolgus monkeys. blood pressure, heart rate, plasma renin activity, and plasma catecholamines were monitored before and after the oral administration of losulazine at a dose which caused a submaximal hypotension in sodium-replete monkeys. the hypotension observed in sodium depleted monkeys was not significantly different from that observed in sodium-replete monkey ... | 1986 | 3533328 |
| experimental proctitis due to rectal infection with chlamydia trachomatis in nonhuman primates. | to serially examine the immunopathogenesis and histopathology of rectal infection with chlamydia trachomatis, we inoculated five cynomolgus monkeys with c. trachomatis serovar e (non-lgv) and five with serovar l2 (lgv). after inoculation, c. trachomatis was isolated from rectal cultures in three of five non-lgv-infected monkeys and in all five lgv-infected monkeys for a period of 10 weeks. lgv-infected monkeys developed a severe hemorrhagic ulcerative proctitis, in contrast to a mild proctitis i ... | 1986 | 3534107 |
| laboratory animal models for human scrub typhus. | a wide variety of animals have been utilized in an attempt to provide the information necessary to bring scrub typhus to the point where it is no longer a threat to man. the laboratory mouse is usually the animal of choice for the study of this disease. the discovery that certain strains of inbred mice are genetically resistant to rickettsia tsutsugamushi, the agent of scrub typhus, has opened new avenues in the study of the immune response to the disease. the cynomolgus monkey, macaca fascicula ... | 1986 | 3534444 |
| the effects of prostaglandin e1 on the adult respiratory distress syndrome in septic primates. | the effects of prostaglandin e1 (pge1) on the adult respiratory distress syndrome were studied in the septic primate (macaca fascicularis). a 30-min infusion of escherichia coli (1 x 10(10)/kg) resulted in severe septic shock and adult respiratory distress syndrome. primates, if living, were killed 4 h after completion of the e. coli infusion. three groups of primates were studied (n = 4 in each group). the control group (group 1) received pge1 at 100 ng/kg/min throughout the experiment. the sep ... | 1986 | 3535596 |
| histologic fate of dermal grafts following implantation for temporomandibular joint meniscal perforation: a preliminary study. | a study was carried out to evaluate the histologic changes of meniscus perforation repair associated with dermal grafts to the temporomandibular joint of cynomolgus monkeys (macaca fascicularis) following surgical perforation of the meniscus. dermal grafts were studied histologically at 3-week, 6-week, 3-month, and 6-month intervals. results showed early attachment of the dermal graft to the meniscus, followed by gradual incorporation of the graft into the meniscus and subsequent return of the m ... | 1986 | 3537891 |
| studies on the pharmacokinetics of zk 96 480, a novel pgi2-mimetic, in rat and cynomolgus monkey. | zk 96 480 (5- [(e)-(1s,5s,6s,7r)-7-hydroxy-6-[(3s,4s)-3-hydroxy-4- methylnona-1,6-diinyl]-bicyclo [3.3.0] octan-3-yliden]-3-oxapentanoic acid) is a novel pgi2-derivative. the pharmacokinetics and biodegradation of the new drug were studied in rat and cynomolgus monkey after i.v. and i.g. administration of 3h-labelled zk 96 480. in a rat liver perfusion experiment zk 96 480 remained unchanged over 90 min. following i.v. and i.g. dosing, the metabolic pattern in the urine and the methanolic extrac ... | 1986 | 3538205 |
| localization of oxytocin and neurophysin in baboon (papio anubis) corpus luteum by immunocytochemistry. | immunoreactive oxytocin is detectable in the corpora lutea of women and cynomolgus monkeys by radioimmunoassay. to localize the presence of oxytocin and neurophysin i in ovarian tissues of subhuman primates, three corpora lutea and ovarian stromal tissues and two fallopian tubes obtained during the menstrual cycle of the baboon and decidua from two pregnant baboons were examined using highly specific antisera against either oxytocin or neurophysin i and peroxidase-antiperoxidase light microscopy ... | 1986 | 3538744 |
| tear and serum antibody response to chlamydia trachomatis antigens during acute chlamydial conjunctivitis in monkeys as determined by immunoblotting. | in this study, we examined the temporal antibody response by immunoblotting analysis in tears and sera of three cynomolgus monkeys (macaca fasicularis) with primary acute chlamydia trachomatis serovar b conjunctivitis. the objective was to identify chlamydial antigens stimulating antibody during the host responses in the course of this self-limiting infection with the rationale that they may be protective antigens. the major outer membrane protein (momp), lipopolysaccharide (lps), and polypeptid ... | 1987 | 3539809 |
| suppression of anti-mouse immunoglobulin antibodies in subhuman primates receiving murine monoclonal antibodies against t cell antigens. | murine monoclonal antibodies stimulate the production of human anti-mouse immunoglobulin antibodies (amia) when administered to patients. this limits their long-term usefulness as therapeutic and diagnostic agents. we report the use of three maneuvers to suppress amia against t cell-specific monoclonal antibodies in cynomolgus monkeys. twelve monkeys received daily i.v. infusions of 1 mg each of anti-leu-2a, -3a, and -5 on days 1 through 10. one group (control) received no suppressive regimen. t ... | 1987 | 3540119 |
| an assessment of nva2-cyclosporine in primate cardiac transplantation. | the immunosuppressive potency, hepatotoxicity, and nephrotoxicity of norvaline2-cyclosporine (nva2-csa), an analog of cyclosporine (csa), were tested in a primate cardiac transplant model. after orthotopic cardiac transplantation in cynomolgus monkeys, immunosuppression was maintained with 16 mg/kg/day of either csa or nva2-csa given intramuscularly in two divided daily doses. immunosuppression was augmented with i.m. methyl-prednisolone, 1.0 mg/kg/day, which was tapered weekly by .1 mg/kg/day t ... | 1987 | 3541313 |
| vaginal immunization against induced cystitis in monkeys. | cynomolgus monkeys received either vaginal immunization with formalin-killed e. coli or vaginal instillation of excipient without the bacteria. at 2, 7, 14 and 21 days after induction of a urinary tract infection with live e. coli, immunized monkeys showed enhanced clearance of bacteriuria compared to non-immunized controls. immunized monkeys also showed increased levels of urinary anti-e. coli iga and igg after the immunizing and infecting procedures. induction of heightened local immunity by v ... | 1987 | 3543412 |
| suppression of spermatogenesis in a nonhuman primate (macaca fascicularis) by concomitant gonadotropin-releasing hormone antagonist and testosterone treatment. | the effects of concomitant testosterone (t)-supplementation on gonadotropin-releasing hormone (gnrh) antagonist-induced testicular regression in cynomolgus monkeys (m. fascicularis) were investigated. four adult monkeys were infused via osmotic minipumps with daily amounts of 2 mg of a potent gnrh antagonist (n-ac-d-nal(2)1, d-pcl-phe2, d-trp3, d-harg (et2)6, d-ala10)-gnrh (rs-68439) for a period of 104 days. androgen substitution was provided via t-filled silastic capsules implanted at initiati ... | 1987 | 3544633 |
| the immunocytochemical localization of new soluble placental tissue proteins (pp14, 16, 17, 19, 20 and pp21) in human and cynomolgus monkey placentae. | apparently placenta-specific placental tissue proteins (pp14 and pp17) and solitary tissue proteins (pp16, 19, 20 and pp21) were investigated by avidin-biotin immunoperoxidase technique in the human and cynomolgus monkey placentae, membranes, decidua and umbilical cords. in human early placentae, pp14, 16, 17, 19 and pp21 were localized mainly in the cytoplasm of villous syncytiotrophoblast. pp20 was localized in the cytoplasm of basal chorionic trophoblasts. in human term placentae, positive st ... | 1987 | 3548605 |
| the afferent input to the magnocellular division of the mediodorsal thalamic nucleus in the monkey, macaca fascicularis. | the origin and termination of fibers to the mediodorsal thalamic nucleus, especially those to the medial, magnocellular part of the nucleus (mdm), have been studied using anterograde and retrograde axonal tracing methods, as well as electrophysiological recording. the results indicate that in addition to its well-known connections to and from the prefrontal cortex, mdm receives fibers from many parts of the basal forebrain, including the ventral pallidum and other parts of the substantia innomin ... | 1987 | 3549796 |
| cardiac xenotransplantation in primates. | successful cardiac xenotransplantation would alleviate the severe shortage of donor organs that presently limits the availability of cardiac transplantation. early attempts at human xenotransplantation achieved minimal success. however, the effectiveness of cyclosporine in nonhuman xenotransplant models has received little experimental investigation. we have therefore studied the effect of cyclosporine-based immunosuppression in primate cardiac xenograft models using cynomolgus monkey donors and ... | 1987 | 3553747 |
| evaluation of the teratogenicity and pharmacokinetics of diflunisal in cynomolgus monkeys. | this study examined the pharmacokinetics and potential teratogenicity of the nonsteroidal antiinflammatory drug, diflunisal, in cynomolgus monkeys. pregnant cynomolgus monkeys were administered 0.5% methyl cellulose, 20 mg/kg/day diflunisal, or 80 mg/kg/day diflunisal on days 25 to 48 of gestation. there was no evidence of maternal toxicity, increased abortion rate, fetal growth retardation, or malformation. these data demonstrate that diflunisal is not teratogenic in cynomolgus monkeys over a d ... | 1987 | 3556822 |
| aqueous humor dynamics in experimental iridocyclitis. | ocular inflammation was induced by intravitreal bovine serum albumin (bsa) injection in one eye of each of six cynomolgus monkeys. the fellow eyes were injected with sterile saline alone. the intraocular pressure decreased by 12.2 +/- 1.3 mmhg (mean +/- se) 2 days after bsa injection and 4.0 +/- 1.1 mmhg after saline injection. aqueous flow and uveoscleral outflow were determined with fluorescein isothiocyanate (fitc) dextran 70. aqueous flow in inflamed eyes averaged 0.32 +/- 0.04 ul/min, less ... | 1987 | 3557859 |
| effects of synthetic glycosides on steroid balance in macaca fascicularis. | the predominantly beta-anomer of diosgenin glucoside (dg) was synthesized and its effects on cholesterol homeostasis were tested in monkeys. cynomolgus macaques (macaca fascicularis) were fed, during two 3-week periods, a semipurified diet with 0.1% cholesterol and a similar ration containing 1% dg, respectively. a chow diet was given for 5 weeks between the experimental periods. cholesterol and bile acid balance were analyzed during the last week of each semipurified diet. diosgenin glucoside r ... | 1987 | 3559397 |
| large iridotomies by the linear incision technique using the neodymium:yag laser at low energy levels. a study using cynomolgus monkeys. | multiple q-switched neodymium:yag (nd:yag) laser impacts at energy levels of 1.0 to 1.7 mj, focused on the iris through the 103-diopter (d) iridotomy-sphincterotomy lens, were applied back and forth in a line across the radial fibers of the mid-peripheral iris in eyes of the cynomolgus monkey (macaca fasicularis) to produce large iridotomies of controllable size. oozing of blood was minimal and no lens capsule damage occurred. these iridotomies showed less iris concussion damage than did convent ... | 1987 | 3561962 |
| effects of methyl mercury on testicular functions in macaca fascicularis monkeys. | these studies were performed to investigate the effects of mehg on testicular function in macaca fascicularis monkeys. in an in vivo study involving oral treatment of adult males macaca fascicularis monkeys with mehg for 20 weeks, changes in spermatozoal production, motility and morphology and in serum testosterone were followed before, during and after treatment. mehg treatment significantly decreased % motile spermatozoa and scores for sperm speed and forward progression and increased % abnorm ... | 1987 | 3562387 |
| embryotoxicity of sex steroidal hormone combinations in nonhuman primates: i. norethisterone acetate + ethinylestradiol and progesterone + estradiol benzoate (macaca mulatta, macaca fascicularis, and papio cynocephalus). | two sex steroid hormone combinations which have been used clinically as tests for detection of early pregnancy were examined for embryotoxic effects in macaques and baboons. norethisterone acetate and ethinyl estradiol (nea + ee) were orally administered to rhesus and cynomolgus monkeys and baboons at dosages ranging from one to 1,000 times the human dose equivalent (hde) during days 20-50 of pregnancy. progesterone and estradiol benzoate (p + eb) were delivered by two to six intramuscular injec ... | 1987 | 3563930 |
| embryotoxicity of sex steroidal hormones in nonhuman primates: ii. hydroxyprogesterone caproate, estradiol valerate. | two sex steroid compounds which have been used clinically for parenteral supportive therapy of pregnancy were examined for embryotoxic effects in rhesus and cynomolgus macaques. hydroxyprogesterone caproate (hpc) alone or in combination with estradiol valerate (ev) were administered intramuscularly (i.m.) to pregnant monkeys at 7-day intervals between 20 and 146 days of gestation and fetuses were examined following cesarean section at 150 +/- 2 days. hpc alone was tested in both species at doses ... | 1987 | 3563931 |
| immunopathologic effects of nickel subsulfide on the primate pulmonary immune system. | the effects of nickel subsulfide (ni3s2) on the pulmonary immune system were evaluated in cynomolgus monkeys that had been previously immunized and repeatedly challenged with sheep red blood cells in specific lung lobes. after instillation of ni3s2, at a final dose of 0.06 mumol/g lung, in one immunized and one control lobe of each monkey, bronchoalveolar lavage cells were evaluated for alterations in cell number and function. neither numbers of antibody-forming cells nor natural killer (nk) cel ... | 1987 | 3564025 |
| a specialized innervation of the tensor tympani muscle in macaca fascicularis. | the innervation of the tensor tympani muscle of the middle ear in macaca fascicularis (cynomolgus monkey) was studied using the horseradish peroxidase (hrp) neural tracing technique. a compact column of small trigeminal motoneurons was labeled ipsilaterally following intramuscular application of hrp to the tensor tympani muscle. this column is located ventral and lateral to the dorsolateral division of the trigeminal motor nucleus, and just medial to the descending trigeminal nerve rootlets. no ... | 1987 | 3567570 |
| [drug dependence test on a cerebral insufficiency improver, aniracetam]. | aniracetam, 1-p-anisoyl-2-pyrrolidinone, is known to be a nootropic or cognitive activator. aniracetam protects against memory and learning deficits without causing effects on motor function and the autonomic nervous system. a drug dependence study on aniracetam utilizing the intragastric route of administration was performed in male cynomolgus monkeys. the behavioral observation test after acute administration revealed that aniracetam at the dose of 25-400 mg/kg did not change the gross behavio ... | 1987 | 3570103 |
| pathogenesis of trachoma: the stimulus for inflammation. | active trachoma is characterized by chronic inflammation of the conjunctiva, and repeated episodes of reinfection are thought to be necessary to sustain this inflammation. it is currently believed that much of the tissue damage is immunologically mediated. to identify which antigens might be responsible for stimulating this continued inflammation, cynomolgus monkeys that had recovered from a previous ocular infection with chlamydia trachomatis were challenged with various antigen preparations. p ... | 1987 | 3571982 |
| the somatotopic organization of the supplementary motor area: intracortical microstimulation mapping. | the somatotopic organization of the supplementary motor area (sma) is commonly held to consist of a rostrocaudal sequence of orofacial, forelimb, and hindlimb representations. recently, however, this somatotopy has been questioned. studies of regional cerebral blood flow in humans and the movements evoked by intracortical electrical stimulation in cynomolgus monkeys have been unable to reveal evidence of distinct orofacial, forelimb, and hindlimb representations rostrocaudally situated along the ... | 1987 | 3572473 |
| behavioral and cardiovascular effects of analogs of adenosine in cynomolgus monkeys. | the behavioral and cardiovascular effects of six metabolically stable analogs of adenosine were studied in cynomolgus monkeys. behavioral effects were determined in monkeys trained to respond under a 30-response fixed-ratio (fr) schedule of food presentation; cardiovascular effects were evaluated in a separate group of unanaesthetized monkeys seated at rest. dose-effect curves for each drug were determined by administering cumulative doses i.v. during sequential components of the experimental se ... | 1987 | 3572798 |
| safety of high-energy neodymium:yag laser pulses in yag sclerostomy. | yag sclerostomy was performed in 15 eyes of nine cynomolgus monkeys. individual pulse energies ranged between 10 and 135 millijoules. total pulse energy ranged between 2,000 and 36,000 millijoules in order to test the extreme range of energy that might be required. both acute effects and chronic effects were studied in the corneal endothelium, the lens capsule, the iris, the ciliary body, the retina, and the sclera. techniques included flat preparations of the corneal endothelium, paraffin secti ... | 1987 | 3573933 |
| structure and growth activities of the mandibular condyle in monkeys (macaca fascicularis): ii. synergistic behavior of cell dynamics and metabolism. | the mandibular condyles of eight growing male monkeys (macaca fascicularis) were analyzed by using a combination of radioautographic and morphometric techniques. this was done with the aim of examining the dynamics in the structure and growth activities of the articular tissue covering as well as of the subchondral zone of erosion. the animals received 1 mci/kg body weight 3h-proline 24 hr and 0.5 mci/kg body weight 3h-thymidine 3 hr prior to death. their age was estimated on the basis of skelet ... | 1987 | 3578082 |
| two-year inhalation toxicity study of petroleum coke in rats and monkeys. | sprague-dawley rats and cynomolgus monkeys were exposed to dust aerosol concentrations (0, 10.2, and 30.7 mg/m3) of micronized delayed process petroleum coke for 6 hr/day, 5 days/week over 2 years. with the exception of pulmonary effects, particularly in the rats, no significant adverse treatment-related effects were observed. both dust-exposed groups of both species exhibited a gray to black discoloration of the lung, an observation consistent with pulmonary deposition of the coke dust, as well ... | 1987 | 3578291 |
| loading patterns and jaw movements during mastication in macaca fascicularis: a bone-strain, electromyographic, and cineradiographic analysis. | rosette strain gage, electromyography (emg), and cineradiographic techniques were used to analyze loading patterns and jaw movements during mastication in macaca fascicularis. the cineradiographic data indicate that macaques generally swallow frequently throughout a chewing sequence, and these swallows are intercalated into a chewing cycle towards the end of a power stroke. the bone strain and jaw movement data indicate that during vigorous mastication the transition between fast close and the p ... | 1987 | 3578494 |
| non-additivity of maximal pilocarpine and cytochalasin effects on outflow facility. | living cynomolgus monkeys received intracameral infusions of pilocarpine hci (p)1 mg ml-1, followed by p + cytochalasin b (cb) 50 microgram ml-1; total outflow facility, measured by two-level constant pressure perfusion, tripled after p alone and then remained stable when cb was added. other eyes received cb 25 micrograms ml-1 or 50 micrograms ml-1, followed by cb + p1 mg ml-1; facility quadrupled to sextupled after cb, but tended to decrease from those levels, although it remained above baselin ... | 1987 | 3582513 |
| transscleral iontophoresis of gentamicin in monkeys. | experiments in rabbits have shown that the novel technique of transscleral iontophoresis is a safe, effective, noninvasive way to produce high concentrations of antibiotics in the vitreous humor. the authors have now studied the effects of repeated transscleral iontophoresis in the eyes of cynomolgus monkeys. six treatments with gentamicin sulfate, 1.5 ma for 10 min, were applied to both eyes of three monkeys over a 2-week period. the concentrations of gentamicin in the vitreous humor 24 hr afte ... | 1987 | 3583629 |
| reinnervation of primate ciliary muscle following ciliary ganglionectomy. | ciliary ganglionectomy and/or postganglionic ciliary neurectomy in the cynomolgus monkey was followed by supersensitivity to intramuscular (i.m.) pilocarpine and lack of response to topical eserine and to electrical stimulation of the edinger-westphal nucleus. normal responsiveness to pilocarpine and eserine returned in most instances after about 6 months. an accommodative response to stimulus of the edinger-westphal nucleus was also present and, as in control eyes, could be blocked by hexametho ... | 1987 | 3583631 |
| evidence for histamine in the urticating hairs of hylesia moths. | an urticarial dermatosis after contact with the urticating hairs of the adult female hylesia moth may occur by several mechanisms including the intradermal injection of inflammatory mediators through the urticating hairs. extracts were prepared from whole moths, urticating hairs, and other moth parts. each of these extracts was subjected to a radioenzyme assay for histamine. histamine was present in extracts made from whole moths and from urticating hairs. extracts made from other moth parts con ... | 1987 | 3585053 |
| scanning electron microscopy of ciliary muscle of monkey eye. | the three-dimensional structure of the ciliary muscles of the cynomolgus monkey eye was studied by scanning electron microscopy after the treatment of the muscle in 8 n hydrochloric acid. the meridional muscle bundles in the outer part of the ciliary body were closely arranged and multilayered, extending in a straight anteroposterior direction from its anterior tips to the distal terminal. the anterior part of the muscle bundles consisting of compactly associated small muscle bundles appeared to ... | 1986 | 3586402 |
| histopathology of hepatocystosis in cynomolgus monkeys (macaca fascicularis) imported from southeast asia. | 1987 | 3586456 | |
| estrogen and androgen receptors in the liver of cynomolgus monkeys (macaca fascicularis). | estrogen receptors (er) and androgen receptors (ar) were evaluated in the hepatic cytosol from cynomolgus macaques to determine if there were differences associated with gender and endogenous hormone secretion. saturable, high affinity binding (kd = 0.2-0.8 nm) was demonstrated for both er and ar from either male or female monkeys. displacement of tritiated estradiol from the er was estrogen specific (including ethinyl estradiol). both androgens and the synthetic progestins (levonorgestrel and n ... | 1987 | 3586659 |
| experimental transvitreal cyanoacrylate retinopexy in a primate model. | we evaluated the use of transvitreal cyanoacrylate retinopexy in the treatment of experimental rhegmatogenous retinal detachment during vitreous surgery in the cynomolgus monkey. the chorioretinal adhesions produced with cyanoacrylate tissue adhesive as compared with those produced by transscleral retinal cryopexy were more rapid in onset as well as stronger. to test the efficacy of cyanoacrylate retinopexy further, a 360-degree peripheral retinectomy was created in five eyes with circumferentia ... | 1987 | 3591878 |
| body fat distribution as a risk factor for coronary artery atherosclerosis in female cynomolgus monkeys. | central fat deposition is associated with increased risk of coronary heart disease morbidity and mortality in women. subcutaneous fat distribution was investigated as a potential factor that might exacerbate diet-induced coronary artery atherosclerosis (caa) in female cynomolgus monkeys (macaca fascicularis) which share with north american caucasian women a gender-related protection against caa. in a retrospective necropsy study (n = 36), the distribution of the antemortem ratio of subscapular/t ... | 1987 | 3593068 |
| preliminary studies on the use of magnetic resonance imaging with gd-dtpa to monitor ovarian function in subhuman primates. | these studies were initiated to explore the use of magnetic resonance imaging (mri) to investigate follicular growth in subhuman primates. four adult cynomolgus monkeys received an i.v. injection of a magnetic resonance (mr) contrast agent, gadolinium diethylenetriaminepentaacetic acid (gd-dtpa), and ovaries were removed 1-20 min later. gd-dtpa is an extracellular fluid marker that is readily detectable in mri. individual ovaries were imaged using a 3-in (7.62 cm) radiofrequency surface coil and ... | 1987 | 3593862 |
| the effect of cyclosporine in chlamydial eye infection. | the effect of cyclosporine (csa) treatment in both primary and secondary chlamydia trachomatis ocular infection in cynomolgus monkeys was studied. following primary infection, csa-treated animals developed severe clinical symptoms which persisted for up to 12 weeks compared to control animals which developed less severe inflammation lasting only 4 to 6 weeks. csa treatment had no effect on the clinical course of a second ocular infection. antigen-specific antibodies developed normally in the ser ... | 1987 | 3595180 |
| chandelier cells in the auditory cortex of monkey and man: a golgi study. | using the golgi method we studied chandelier cells in the auditory cortex of monkeys (macaca irus) subjected to hypoxia before perfusion, and in newborn humans deceased in hypoxic states. in humans these cells have round or ovoid bodies showing usually beaded and sparsely-spined dendrites. these may arise either from both apical and basal poles or from all directions of the soma. with respect to their axons, we found two different types of chandelier cells: cells with extended chandelier complex ... | 1987 | 3595776 |
| cynomolgus and rhesus monkey visual pigments. application of fourier transform smoothing and statistical techniques to the determination of spectral parameters. | microspectrophotometric measurements were performed on 217 photoreceptors from cynomolgus, macaca fascicularis, and rhesus, m. mulatta, monkeys. the distributions of cell types, for rods and blue, green, and red cones were: 52, 12, 47, and 44, respectively, for the cynomolgus, and 22, 4, 13, and 13 for the rhesus. visual cells were obtained fresh (unfixed), mounted in various media (some containing 11-cis-retinal), and then located visually under dim red (650 nm) illumination. absolute absorbanc ... | 1987 | 3598558 |
| comparison of pharmacokinetic behaviors of two human interferons (lb-ifn-alpha and re-ifn-alpha a) in cynomolgus monkeys by 2'-5' oligoadenylate synthetase assay. | two human interferons (ifns), natural lymphoblastoid ifn-alpha (lb-ifn-alpha) and recombinant ifn-alpha (re-ifn-alpha a) were compared for their induction of 2'-5' oligoadenylate (2-5a) synthetase and pharmacokinetic behaviors in cynomolgus monkeys. in in vitro experiments, the enzyme activity induced in an epithelial cell strain from human amniotic membrane (fl) cells was much higher than that in primary culture of cynomolgus monkey kidney (pmk) cells, and lb-ifn-alpha induced higher levels of ... | 1986 | 3599526 |
| conditioning and breeding facilities for the cynomolgus monkey (macaca fascicularis) in the philippines: a progress report on the siconbrec project. | large-scale breeding of macaca fascicularis in the country of origin is a way in which the demands of the research community can be met whilst the feral population of monkeys is safeguarded. the establishment of the siconbrec project and the success of its breeding programme to date is clear evidence of the future trend in the supply of non-human primates for biomedical research. | 1987 | 3599877 |
| fatal fatty liver-kidney syndrome in obese monkeys. | a fatal syndrome associated with brief periods of anorexia or acute weight loss was noted in monkeys. affected monkeys died unexpectedly or after a very short illness. consistent gross findings at necropsy were enlarged, pale yellow livers, pale tan to yellow kidneys, abundant deposits of body fat and empty gastrointestinal tracts. fatty change of the liver and kidney was the predominant and characteristic lesion found microscopically. most of the monkeys were female macaca fascicularis greater ... | 1987 | 3599891 |
| iliac biopsy for histomorphometric analysis of trabecular bone in cynomolgus monkeys and baboons. | a humane, repeatable surgical technique was developed to harvest trabecular bone for histomorphometry from nonhuman primates. using a direct surgical approach to the iliac crest, bone specimens with a mean cross sectional area of trabecular bone plus marrow (at) of 12.02 and 18.07 mm2 were harvested from cynomolgus monkeys (macaca fascicularis) and baboons (papio anubis) respectively. the method provides bone samples with little artifact or bone dust contamination, and easy orientation and repro ... | 1987 | 3599893 |
| long-term consequences of exposure to ozone. ii. structural alterations in lung collagen of monkeys. | the effects of chronic exposure to ozone on lung collagen crosslinking were investigated in two groups of juvenile cynomolgus monkeys exposed to 0.61 ppm of ozone 8 hrs per day for 1 year. one group was killed immediately after the exposure period; the second exposed group breathed filtered air for 6 months after the ozone exposure before being killed. previous studies of these monkeys had revealed that lung collagen content was increased in both exposed groups (j.a. last et al., (1984). toxicol ... | 1987 | 3603563 |
| pharmacokinetics and metabolism of mespirenone, a new aldosterone antagonist, in rat and cynomolgus monkey. | the pharmacokinetics and metabolism of mespirenone were examined in rat and cynomolgus monkey using the tritiated drug. following i.v. administration, mespirenone exhibited a short half-life and a high plasma clearance; after oral administration the unchanged compound was not detectable. thus, mespirenone has to be considered a pro-drug. from rat urine three metabolites were isolated by h.p.l.c. and identified by mass spectra and 1h n.m.r., all having retained the 7 alpha-sulphur substituent as ... | 1987 | 3604266 |
| magnetic resonance imaging of monkey placenta with manganese enhancement. | magnetic resonance imaging of pregnant cynomolgus monkeys in the last trimester was done on a picker instrument (picker international, inc., northford, connecticut) operating at 0.26 tesla. both inversion-recovery and spin-echo proton images were obtained, demonstrating good detail of fetal and maternal anatomy. the placenta was particularly easy to identify, and its image was further enhanced by a bolus infusion of manganese chloride. manganese is one of several paramagnetic ions that shortens ... | 1987 | 3605252 |
| pharmacokinetics of the novel cephalosporin cefepime (bmy-28142) in rats and monkeys. | the disposition of the novel cephalosporin cefepime (bmy-28142) was characterized for intravenous administration of single doses to rats and cynomolgus monkeys, the species used most extensively for safety evaluation of the compound. serial blood samples were collected from individual animals, and plasma was analyzed for intact cefepime by a high-pressure liquid chromatography-uv method. assay results were evaluated by compartmental and noncompartmental methods to characterize pharmacokinetics f ... | 1987 | 3606078 |
| pregnancy-associated inhibition of coronary artery atherosclerosis in monkeys. evidence of a relationship with endogenous estrogen. | we investigated the influence of repeated pregnancy on diet-induced atherosclerosis in cynomolgus monkeys and sought to determine if circulating endogenous reproductive steroid levels were associated with the extent of coronary artery atherosclerosis. at necropsy, females which were pregnant one or more times were found to have coronary artery atherosclerosis which was one-fourth as extensive as that of intact females which had not been pregnant. extent of coronary artery atherosclerosis correla ... | 1987 | 3606465 |
| ultrastructural aspects of cynomolgus atherosclerotic carotid artery lesions on cholestyramine 'regression' treatment. | the carotid artery lesions of atherosclerotic cynomolgus monkeys treated with cholestyramine and studied with scanning electron microscopy appeared to be less bulging and largely covered by endothelial cells. with transmission electron microscopy these lesions showed an evident disappearance of cells and of extra- and intracellular lipid; a marked relative increase of fibrous material in the intercellular matrix, chiefly collagen and elastin fibers, was noted. | 1986 | 3606883 |
| dietary carbohydrate type and cholesterol-induced hypercholesterolemia in cynomolgus monkeys: influence of oral antibiotic. | the relationship of carbohydrate type to cholesterol-induced hypercholesterolemia and the potential role of intestinal flora in the above process were examined in 12 male cynomolgus monkeys (m. fascicularis). semipurified diets provided two types of carbohydrates (starch or sucrose, 49% by calorie) with 0.4 mg cholesterol/kcal. six weeks of the starch diet resulted in significantly enhanced hypercholesterolemia when compared to sucrose diet. starch in relation to sucrose produced cholesterol enr ... | 1987 | 3606891 |
| corneal thickness changes following sleep and overnight contact lens wear in the primate (macaca fascicularis). | corneal thickness was monitored on seven cynomolgus monkeys (macaca fascicularis) over a 76 hour period. during this time, corneal thickness measurements were also made on six monkeys after overnight wear of a hydrogel contact lens in one eye. mean corneal thickness was 417 +/- 12 microns. an overall diurnal variation of 16 +/- 5 microns (3.8 +/- 1.2%) was found. during the first half hour after waking, corneal thickness changes ranged from -9 microns to +14 microns. after overnight contact lens ... | 1987 | 3608568 |
| metabolic and peroxisome proliferation studies with di(2-ethylhexyl)phthalate in rats and monkeys. | male fischer 344 rats and cynomolgus monkeys were treated with various doses of di(2-ethylhexyl)phthalate (dehp) for at least 21 days. there was metabolic, biochemical, and morphological evidence for peroxisomal proliferation in rats that consumed diets containing 1000 ppm dehp and above. these diets were estimated to provide average daily doses of about 100 mg/kg of dehp. in contrast, peroxisomal proliferation was not observed in monkeys that received up to 500 mg/kg/day of dehp by gavage. the ... | 1987 | 3617067 |
| longitudinal study of craniofacial growth in macaca fascicularis. | this paper is an analysis of normal craniofacial growth in adolescent crab-eating macaques (macaca fascicularis). eight female adolescent monkeys were used in this study. their individual craniofacial growth was studied for a 24-month period utilizing tantalum implants and roentgenographic cephalograms. throughout the observation period, each monkey consistently showed a class i molar relationship with a good overjet and overbite. the amount of anterior displacement of the maxilla and the mandib ... | 1987 | 3618754 |
| fiber-type composition of selected hindlimb muscles of a primate (cynomolgus monkey). | the distribution of fiber types in selected leg and thigh muscles of three male cynomolgus monkeys were determined. almost all fibers could be classified as fast-glycolytic (fg), fast-oxidative glycolytic (fog), or slow-oxidative (so) according to the qualitative histochemical staining scheme described by peter et al. (1972). most muscles showed regional variations in fiber-type distributions, i.e., the percent so was higher and the percent fg was lower in the deep, compared to the superficial, ... | 1987 | 3619081 |
| symptomatic dermographism (factitious urticaria)--passive transfer experiments from human to monkey. | passive transfer experiments were carried out on three species of monkey, macaca mulatta, macaca nemestrina and macaca fascicularis, using human serum from patients affected with severe symptomatic dermographism (factitious urticaria), cholinergic urticaria, chronic idiopathic urticaria and normal subjects. the monkeys were tested for dermographism by means of a calibrated dermographometer 24 h after intradermal injection of the serum, using evans blue as a marker. positive responses were seen i ... | 1987 | 3620341 |
| [in utero surgery of diaphragmatic hernia in macaca fascicularis]. | the aim of this study is to be able to perform on the animal (macacus cynomolgus) a specific in utero surgical procedure for correcting congenital diaphragmatic hernia, in order to do the same on human fetuses. the surgical technique consist in operating in utero, and to put a silastic patch on the diaphragm. a good tocolysis is very necessary to prevent early abortion. finally the fetuses' surviving is the main problem. | 1987 | 3621387 |
| dietary treatment of atherosclerosis abolishes hyperresponsiveness to serotonin: implications for vasospasm. | diet-induced atherosclerosis in primates impairs vasodilator responses and greatly potentiates vasoconstrictor responses to serotonin. serotonin may play an important role in the pathogenesis of vasospasm. in diet-induced regression of atherosclerosis, intimal lesions are reduced, but maximal vasodilator responses do not improve, perhaps because of vascular fibrosis. our goal was to determine whether dietary treatment of atherosclerosis reverses the augmented vasoconstrictor responses to seroton ... | 1987 | 3621497 |
| the inheritance of a macaca fascicularis red cell antigen detected by campath-1 antibody. | campath-1 monoclonal antibody is reactive with human lymphocytes and monocytes and it has been shown to bind to antigens on the red cells of a number of primate species, including macaca fascicularis. our study within a closed colony of breeding m. fascicularis monkeys has confirmed this finding, and shown that the antibody identified a single red cell antigen inherited in mendelian fashion as a dominant character. we have, further, confirmed that the antigen is present on blood lymphocytes, eve ... | 1987 | 3623632 |
| renin angiotensin aldosterone axis, including aldosterone binding globulin and blood pressure in three species of nonhuman primates. | variables of renin-angiotensin-aldosterone axis with inclusion of protein binding to specific plasma globulin (abg), plasma cortisol, and the blood pressure (bp) were measured in 24 chimpanzees, 4 gorillas, and 16 cynomolgus monkeys. abg activity was readily detected in plasma from the primates. in chimpanzees and gorillas, all the variables under baseline conditions were similar to those in humans. in cynomolgus (macaca fascicularis), both the abg binding capacity for aldosterone and the diasto ... | 1987 | 3625756 |
| testosterone and its metabolites in male cynomolgus monkeys (macaca fascicularis): behavior and biochemistry. | to extend our previous study on the behavioral effects of testosterone propionate (tp) and dihydrotestosterone propionate (dhtp) to a dose-range producing supra-physiological plasma androgen levels, 4 castrated cynomolgus monkeys were tested with the same 4 females during successive 4-week treatment periods while receiving 800 micrograms, 1.6 mg, 3.2 mg, 6.4 mg and 12.8 mg of tp or dhtp sc/day in counterbalanced order (16 pairs, 828 1-hr tests). both androgens increased male sexual activity, but ... | 1987 | 3628550 |
| merkel-neurite complexes in the fungiform papillae of two species of monkeys. | merkel-neurite complexes in tongues of japanese and cynomolgus monkeys were examined by means of light and electron microscopy. merkel-neurite complexes were found preferentially in the epithelium of fungiform papillae located at the tip of the tongue. it appears that the anterior fungiform papillae of the monkey are highly adapted for both taste and mechanical sensation. | 1987 | 3652163 |
| effect of levo-acetylcarnitine on p300-like potentials of the normal monkey. | endogenous components of evoked potentials resembling p300 in human beings were sequentially studied in four cynomolgus monkeys (macaca fascicularis using an auditory "oddball" paradigm, after classical conditioning training. when robust p300-like signals were obtained, each animal underwent further recording sessions in which a placebo, l-carnitine or l-acetylcarnitine (lac) was injected. only lac induced an amplitude increment of p300 waves in all the animals and a latency decrement in two ani ... | 1987 | 3652929 |
| cultured trabecular-meshwork cells: immunohistochemical and lectin-binding characteristics. | we examined the extracellular matrix formation and lectin-binding properties of cultured trabecular-meshwork cells established from cynomolgus monkey and bovine eyes. using an avidin-biotin complex method, we found that the extracellular matrix in both the monkey and bovine cultures stained intensely with antibodies to fibronectin, type iv collagen, and laminin. these materials were especially prominent when the cultured monkey trabecular-meshwork cells aggregated in clusters, manifesting their ... | 1987 | 3653292 |
| d-penicillamine and beta-aminopropionitrile effects on experimental filtering surgery. | we studied the effect of two compounds, beta-aminopropionitrile (bapn) and d-penicillamine on the success of experimental glaucoma filtering surgery in cynomolgus monkeys. all animals had laser-induced glaucoma and underwent punch sclerectomy operations. eyes treated with bapn or d-penicillamine maintained successful filtration for at least 3 days longer than nondrug-treated controls. this effect, while statistically significant (p less than 0.05), was temporary. the lack of more substantial imp ... | 1987 | 3654136 |
| effects of bilateral vagotomy on the ultrastructure of the cardiac ganglia in the monkey (macaca fascicularis). | this study describes the effects of bilateral vagotomy on the ultrastructure of the cardiac ganglia of the monkey (macaca fascicularis). one to three days after bilateral vagotomy there is widespread glycogen accumulation in the cytoplasm of the principal cardiac neurons. this is associated with distension of the granular endoplasmic reticulum and the loss of ribosomes from the cisternae. between five and ten days after operation, about 10% of the neuronal profiles show an overall increase in el ... | 1987 | 3654342 |
| the effect of timing of clot removal on chronic vasospasm in a primate model. | the effect of complete clot removal at times from 48 to 96 hours after subarachnoid hemorrhage (sah) on the development of chronic cerebral vasospasm was evaluated to determine whether there is a critical point after which clot removal is ineffective in preventing vasospasm. thirty cynomolgus monkeys were randomized to one of five groups: sham-operated group, clot removal at 48 hours after sah (48-hour group), clot removal at 72 hours after sah (72-hour group), clot removal at 96 hours after sah ... | 1987 | 3655894 |
| responses of spinothalamic tract cells in the superficial dorsal horn of the primate lumbar spinal cord. | 1. the responses of thirty-five spinothalamic tract (s.t.t.) cells in or near lamina i of the dorsal horn were examined in chloralose- and barbiturate-anaesthetized monkeys (macaca fascicularis). many of the cells could be classified on the basis of receptive field properties as either wide dynamic range (w.d.r.) cells or as high-threshold (h.t.) cells. 2. thalamic stimulation sites for antidromic activation of the s.t.t. cells were in or around the ventral posterior lateral nucleus. axons of th ... | 1987 | 3656204 |
| methodological approaches to primate behavioral toxicological testing. | the monkey may often be the best model with which to characterize low-level effects of neurotoxicants, including those produced by developmental exposure. the nervous system of the monkey is very similar to the human and, like humans, monkeys have a long period of gestation, infancy, and sexual immaturity during which the nervous system continues to develop. the sensory systems of monkeys are very similar to humans, and intellectual capabilities may be tested that are not possible using other co ... | 1987 | 3657752 |
| development and use of a radioimmunoassay for d-(-)-norgestrel 17 beta-cyclopentanecarboxylate. | the synthesis of the 6 alpha-carboxymethylmercapto bsa and homologous histamine conjugate of d-(-)-norgestrel 17 beta-cyclopentanecarboxylate is reported. using the bsa conjugate as an immunogen for the development of antibody in the rabbit and the 125i-histamine conjugate as the radioligand, a radioimmunoassay (ria) for the ester was developed. serum profiles of the free alcohol and ester were determined following iv or im injection in macaques. peak values for the ester (about 12 ng/ml) were o ... | 1986 | 3660438 |
| cynomolgus monkey twins. | 1987 | 3660550 | |
| arterial uptake indices of low density lipoproteins after fatty streak formation in cynomolgus monkeys. | to evaluate changes in arterial wall uptake of an atherogenic lipoprotein in early atherogenesis the uptake of labelled low density lipoprotein was measured in four segments of aorta in cynomolgus monkeys with diet induced fatty streaks. the influx rate of low density lipoprotein was estimated from a simple kinetic model. the mean influx rate, expressed as plasma equivalents of tracer, was 69 nl.cm-2 per hour in fatty streak monkeys and 28 nl.cm-2 per hour in controls (p less than 0.001). using ... | 1987 | 3664535 |