Publications
Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
---|
platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with leishmania (viannia) braziliensis. | platelet-activating factor (paf) is produced by macrophages during inflammation and infections. we evaluated whether paf is able to modulate the infection of human macrophages by leishmania braziliensis, the main leishmania sp. in brazil. monocyte-derived macrophages were incubated with promastigote forms in absence or presence of exogenous paf. we observed that the treatment of macrophages with low concentrations of paf prior to infection increased the phagocytosis of l. braziliensis. more impo ... | 2017 | 28830073 |
leishmania infection in bats from a non-endemic region of leishmaniasis in brazil. | leishmaniasis is a complex of zoonotic diseases caused by parasites of the genus leishmania, which can develop in domestic as well as wild animals and humans throughout the world. currently, this disease is spreading in rural and urban areas of non-endemic regions in brazil. recently, bats have gained epidemiological significance in leishmaniasis due to its close relationship with human settlements. in this study, we investigated the presence of leishmania spp. dna in blood samples from 448 bats ... | 2017 | 28831941 |
profiling gene expression of antimony response genes in leishmania (viannia) panamensis and infected macrophages and its relationship with drug susceptibility. | the mechanisms of leishmania resistance to antimonials have been primarily determined in experimentally derived leishmania strains. however, their participation in the susceptibility phenotype in field isolates has not been conclusively established. being an intracellular parasite, the activity of antileishmanials is dependent on internalization of drugs into host cells and effective delivery to the intracellular compartments inhabited by the parasite. in this study we quantified and comparative ... | 2017 | 28843396 |
the use of herbs against neglected diseases: evaluation of in vitro leishmanicidal and trypanocidal activity of stryphnodendron rotundifolium mart. | the evaluation of the leishmanicidal and trypanocidal activity of the hydroalcoholic extract of the bark of stryphnodendron rotundifolium mart. (ehcsr) was carried out to find an alternative treatment for parasitic diseases. ehcsr was prepared and used at four different concentrations (1000, 500, 250, 125 μg/ml) in in vitro assays for activity against leishmania promastigotes using the species leishmania brasiliensis and leishmania infantum and for trypanocidal activity using the epimastigotes o ... | 2017 | 28855804 |