Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| development of genomic microsatellite markers in carthamus tinctorius l. (safflower) using next generation sequencing and assessment of their cross-species transferability and utility for diversity analysis. | safflower (carthamus tinctorius l.), an asteraceae member, yields high quality edible oil rich in unsaturated fatty acids and is resilient to dry conditions. the crop holds tremendous potential for improvement through concerted molecular breeding programs due to the availability of significant genetic and phenotypic diversity. genomic resources that could facilitate such breeding programs remain largely underdeveloped in the crop. the present study was initiated to develop a large set of novel m ... | 2015 | 26287743 |
| protective effect of salvia miltiorrhiza and carthamus tinctorius extract against lipopolysaccharide-induced liver injury. | to investigate the hepatoprotective effects and mechanisms of an extract of salvia miltiorrhiza and carthamus tinctorius in vivo. | 2015 | 26290634 |
| danhong injection protects cardiomyocytes against hypoxia/reoxygenation- and h2o2-induced injury by inhibiting mitochondrial permeability transition pore opening. | danhong injection (dhi), a chinese medical product extracted from radix et rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, honghua in chinese), has been widely used for the treatment of ischemic heart disease, and clinical and experimental studies have demonstrated the protective effects against myocardial ischemia/reperfusion injury. nevertheless, the underlying cellular mechanisms responsible for thi ... | 2015 | 26320687 |
| expression of bioactive recombinant human fibroblast growth factor 10 in carthamus tinctorius l. seeds. | fibroblast growth factor 10 (fgf10) is a member of the fgf superfamily. it exhibits diverse biological functions, and is extensively used for fundamental research and clinical applications involving hair growth, tissue repair, and burn wounds. oil bodies, obtained from oil seeds, have been exploited for a variety of biotechnology applications. the use of oil bodies reduces purification steps and costs associated with the production of heterogonous proteins. here, recombinant human fgf10 (rhfgf10 ... | 2015 | 26384708 |
| duration of emission of volatile organic compounds from mechanically damaged plant leaves. | classical biological control of invasive alien weeds depends on the use of arthropod herbivores that are sufficiently host specific to avoid risk of injuring nontarget plants. host plant specificity is usually evaluated by using a combination of behavioral and developmental experiments under choice, no-choice and field conditions. secondary plant compounds are likely to have an important influence on host plant specificity. however, relatively little is known about the volatile organic compounds ... | 2015 | 26398629 |
| development and validation of a uflc-ms/ms method for the determination of anhydrosafflor yellow b in rat plasma and its application to pharmacokinetic study. | a sensitive ultrafast liquid chromatography coupled with triple quadrupole mass spectrometric (uflc-ms/ms) method for the quantification of anhydrosafflor yellow b (ahsyb), a major active water-soluble pigment from carthamus tinctorius, in rat plasma has been developed and validated. sample preparation was achieved by protein precipitation of plasma with four volumes of methanol. rutin was used as the internal standard (is). the analytes were separated using a c18 column with an 8min gradient el ... | 2015 | 26409263 |
| effect of drought on safflower natural dyes and their biological activities. | drought is the main abiotic constraint that affects crop species behaviour regarding bio-chemical responses. the current study was conducted to examine the effect of water deficit on growth, phenolic and carotenoid contents as well as the antioxidant and antimicrobial activities of two carthamus tinctorius varieties (jawhara and 104) flowers. hence, plants were treated with different levels of water deficit: control (100 %), moderate water deficit (50 %) and severe water deficit (25 %). obtained ... | 2014 | 26417239 |
| a case study on the genetic origin of the high oleic acid trait through fad2-1 dna sequence variation in safflower (carthamus tinctorius l.). | the safflower (carthamus tinctorius l.) is considered a strongly domesticated species with a long history of cultivation. the hybridization of safflower with its wild relatives has played an important role in the evolution of cultivars and is of particular interest with regards to their production of high quality edible oils. original safflower varieties were all rich in linoleic acid, while varieties rich in oleic acid have risen to prominence in recent decades. the high oleic acid trait is con ... | 2015 | 26442008 |
| identification and evaluation of reference genes for accurate transcription normalization in safflower under different experimental conditions. | safflower (carthamus tinctorius l.) has received a significant amount of attention as a medicinal plant and oilseed crop. gene expression studies provide a theoretical molecular biology foundation for improving new traits and developing new cultivars. real-time quantitative pcr (rt-qpcr) has become a crucial approach for gene expression analysis. in addition, appropriate reference genes (rgs) are essential for accurate and rapid relative quantification analysis of gene expression. in this study, ... | 2015 | 26457898 |
| selective ion monitoring of quinochalcone c-glycoside markers for the simultaneous identification of carthamus tinctorius l. in eleven chinese patent medicines by uhplc/qtof ms. | current china pharmacopoeia standards for the chinese patent medicines (cpms) that contain one or several the same drug(s) employ case-dependent tlc or hplc approaches to achieve qualitative identification. a qualitative "monomethod-heterotrait matrix" (mhm) strategy is thus proposed, by selective monitoring of multi-biomarkers, to achieve the identification of different cpms. carthamus tinctorius l. (safflower) is a reputable gynecological herbal medicine containing characteristic quinochalcone ... | 2016 | 26476296 |
| de novo sequencing and analysis of the safflower transcriptome to discover putative genes associated with safflor yellow in carthamus tinctorius l. | safflower (carthamus tinctorius l.), an important traditional chinese medicine, is cultured widely for its pharmacological effects, but little is known regarding the genes related to the metabolic regulation of the safflower's yellow pigment. to investigate genes related to safflor yellow biosynthesis, 454 pyrosequencing of flower rna at different developmental stages was performed, generating large databases.in this study, we analyzed 454 sequencing data from different flowering stages in saffl ... | 2015 | 26516840 |
| metabolomics reveals hippocampal metabolic fluctuations of postoperative fatigue syndrome and anti-fatigue effect of carthamus tinctorius l extract in rat model. | postoperative fatigue syndrome (pofs) is a common clinical complication followed by almost every major abdominal surgery. there is not a full explanation to the etiology of pofs, especially its central mechanism. carthamus tinctorius l is a classic traditional chinese medicine (tcm) which could exert the anti-fatigue effect on pofs. however, its mechanism is still lacking. here, ultra-high performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (uhplc-q-tofms) ... | 2015 | 26577245 |
| expression of atp synthase cf1 alpha subunit gene (ctl-spn) as screened by the cdna-srap approach is correlated with spininess in carthamus tinctorius l. | the safflower floret is a traditional chinese medicine used to promote blood circulation and remove obstruction in the channels. the spines on its bracts are considered a handicap when manual harvest is involved. in this study, cdna-srap was used to systematically investigate which genes are associated with the spines. sixty pairs of possible primer combinations were used on two cdna pools representing spininess and spinelessness. six transcript-derived fragments were identified, of which two wi ... | 2015 | 26669008 |
| evaluation of the effects of active fractions of chinese medicine formulas on il-1β, il-6, and tnf-α release from ana-1 murine macrophages. | yaotongning (ytn) is a traditional chinese medicine (tcm) that contains ten component medicinal materials (cmms) and uses chinese rice wine as a vehicle to enhance its efficacy. ytn has been used for rheumatoid arthritis (ra) treatment in china for decades and has been reported to have anti-inflammatory and analgesic effects, as well as to strengthen the immune system. | 2016 | 26732631 |
| hydroxysafflor yellow a attenuates bleomycin-induced pulmonary fibrosis in mice. | hydroxysafflor yellow a (hsya) is an active component of carthamus tinctorius l., and we want to investigate whether hsya attenuates pulmonary fibrosis induced by bleomycin (blm) in mice. the mice received a blm via oropharyngeal aspiration, and hsya was intraperitoneally injected. arterial blood gas analysis was performed. morphological changes and hydroxyproline content were measured. mrna expression of transforming growth factor-β1 (tgf-β1), connective tissue growth factor, α-smooth muscle ac ... | 2016 | 26777519 |
| uflc-q-tof/ms based screening and identification of the metabolites in plasma, bile, urine and feces of normal and blood stasis rats after oral administration of hydroxysafflor yellow a. | the dried flower of carthamus tinctorius l. (honghua) is a widely used traditional chinese medicine in clinics to treat coronary heart disease, hypertension, and cerebrovascular disease due to its functions of ameliorating circulation and removing blood stasis. hydroxysafflor yellow a (hsya) is an active marker component of honghua. in this paper, ultra-flow liquid chromatography coupled with quadrupole-time-of-flight mass-spectrometry (uflc-q-tof/ms) was established and successfully applied to ... | 2016 | 26827279 |
| insight of saffron proteome by gel-electrophoresis. | saffron is a spice comprised of the dried stigmas and styles of crocus sativus l. flowers and, since it is very expensive, it is frequently adulterated. so far, proteomic tools have never been applied to characterize the proteome of saffron or identify possible cases of fraud. in this study, 1d-gel electrophoresis was carried out to characterize the protein profile of (i) fresh stigmas and styles of the plant; (ii) dried stigmas and styles from different geographical origins (spanish, italian, g ... | 2016 | 26840283 |
| metabolic profile of anhydrosafflor yellow b in rats by ultra-fast liquid chromatography/quadrupole time-of-flight mass spectrometry. | anhydrosafflor yellow b (ahsyb) is one of the major active water-soluble pigments from carthamus tinctorius, which has been found to inhibit adp-induced platelet aggregation and possess significant antioxidant activity. however, the metabolic fate of ahsyb in vivo remains unknown. in order to explore whether ahsyb is extensively metabolized, the metabolites of ahsyb in plasma, urine, bile, and feces samples after intravenous administration to the rats were investigated by ultra-fast liquid chrom ... | 2016 | 26871281 |
| synergistic antihypertensive effect of carthamus tinctorius l. extract and captopril in l-name-induced hypertensive rats via restoration of enos and at₁r expression. | this study examined the effect of carthamus tinctorius (ct) extract plus captopril treatment on blood pressure, vascular function, nitric oxide (no) bioavailability, oxidative stress and renin-angiotensin system (ras) in n(ω)-nitro-l-arginine methyl ester (l-name)-induced hypertension. rats were treated with l-name (40 mg/kg/day) for five weeks and given ct extract (75 or 150 or 300 or 500 mg/kg/day): captopril (5 mg/kg/day) or ct extract (300 mg/kg/day) plus captopril (5 mg/kg/day) for two cons ... | 2016 | 26938552 |
| danhong injection attenuates isoproterenol-induced cardiac hypertrophy by regulating p38 and nf-κb pathway. | danhong injection (dhi), derived from rhizoma salviae miltiorrhizae (salvia miltiorrhiza bge., labiatae, danshen in chinese) and flos carthami (carthamus tinctorius l., compositae, salvia militiorrhiza bunge), is an extensively-used chinese material standardized clinical product for treatment of cardiovascular diseases. | 2016 | 26970569 |
| genetic and epigenetic approaches for the possible detection of adulteration and auto-adulteration in saffron (crocus sativus l.) spice. | saffron (crocus sativus l.) is very expensive and, because of this, often subject to adulteration. modern genetic fingerprinting techniques are an alternative low cost technology to the existing chemical techniques, which are used to control the purity of food products. buddleja officinalis maxim, gardenia jasminoides ellis, curcuma longa l., carthamus tinctorius l. and calendula officinalis l. are among the most frequently-used adulterants in saffron spice. three commercial kits were compared c ... | 2016 | 26978342 |
| intraspecific variability of carbon isotope discrimination and its correlation with grain yield in safflower: prospects for selection in a mediterranean climate. | the goals of the present study were to obtain a first estimate of intraspecific variability of carbon isotope discrimination (δ) in safflower, a thistle-like herbaceous plant, and to determine the statistical relationship between δ and grain yield as well as its components in a collection of 45 accessions of different origins. grain yield and aboveground biomass, harvest index, average grain weight, and δ (measured on the bulk leaf organic matter) were investigated in experimental field conditio ... | 2016 | 26982084 |
| hydroxysafflor yellow a (hsya) attenuates hypoxic pulmonary arterial remodelling and reverses right ventricular hypertrophy in rats. | carthamus tinctorius l. is a traditional herbal medicine native to china with properties of promoting blood circulation and removing blood stasis, which is used for the treatment of cerebrovascular and cardiovascular diseases. hydroxysafflor yellow a (hsya) is the main constituent isolated from the flower of carthamus tinctorius l. which is used as a marker substance in the quality control of carthamus tinctorius l. in chinese pharmacopeia. | 2016 | 27063983 |
| hydroxysafflor yellow a protects neurons from excitotoxic death through inhibition of nmdars. | excessive glutamate release causes overactivation of n-methyld-aspartate receptors (nmdars), leading to excitatory neuronal damage in cerebral ischemia. hydroxysafflor yellow a (hsya), a compound extracted from carthamus tinctorius l., has been reported to exert a neuroprotective effect in many pathological conditions, including brain ischemia. however, the underlying mechanism of hsya's effect on neurons remains elusive. in the present study, we conducted experiments using patch-clamp recording ... | 2017 | 27067428 |
| phytochemistry and pharmacology of carthamus tinctorius l. | carthamus tinctorius l. is a multifunctional cash crop. its flowers and seeds are extensively used in traditional herbal medicine in china, korea, japan, and other asian countries, for treating various ailments such as gynecological, cardiovascular, and cerebrovascular diseases as well as blood stasis and osteoporosis. more than 100 compounds have been isolated and identified from c. tinctorius. flavonoids and alkaloids, especially the quinochalcone c-glycoside hydroxysafflor yellow a, n-(p-coum ... | 2016 | 27080938 |
| attenuation of the lps-induced, erk-mediated upregulation of fibrosis-related factors fgf-2, upa, mmp-2, and mmp-9 by carthamus tinctorius l in cardiomyoblasts. | severe and potentially fatal hypotension and cardiac contractile dysfunction are common symptoms in patients with sepsis. lps was previously found to dramatically upregulate expression of fibrosis-related factors fgf-2, upa, mmp-2, and mmp-9 in primary cardiac fibroblasts. mmps are capable of denaturing and degrading fibrillar collagens and other components of the extracellular matrix (ecm). studies have shown that dysregulation of expression of mmps is associated with development of myocardial ... | 2017 | 27098997 |
| antioxidant effects of hydroxysafflor yellow a and acetyl-11-keto-β-boswellic acid in combination on isoproterenol-induced myocardial injury in rats. | oxidative stress plays an important role in the initiation and development of myocardial injury (mi). the peroxisome proliferator-activated receptor gamma coactivator-1α (pgc‑1α)/nuclear factor erythroid 2-related factor 2 (nrf2) pathway is considered to be a potential target for cardioprotection in mi. acetyl-11-keto-β-boswellic acid (akba) is the major organic acid component extracted from boswellia serrata roxb. ex colebr. hydroxysafflor yellow a (hsya) is the principal active constituent of c ... | 2016 | 27121241 |
| the mixture of salvia miltiorrhiza-carthamus tinctorius (danhong injection) alleviates low-dose aspirin induced gastric mucosal damage in rats. | danhong injection (dhi) is quite often used in combination with low-dose aspirin (asa, 75-325mg daily) in clinic, particularly for the treatment of cardiovascular diseases. exploring their interaction profile is of great clinical importance. | 2016 | 27161407 |
| synergistic cardioprotective effects of danshensu and hydroxysafflor yellow a against myocardial ischemia-reperfusion injury are mediated through the akt/nrf2/ho-1 pathway. | in clinical practice, the traditional chinese medicinal herbs, radix salvia miltiorrhiza and carthamus tinctorius l., are usually prescribed in combination due to their significant cardioprotective effects. however, the mechanisms responsible for these combined effects remain unknown. thus, in this study, we investigated the mechanisms responsible for the combined effects of danshensu (dss) and hydroxysafflor yellow a (hsya) by establishing a rat model of myocardial ischemia/reperfusion (mi/r), ... | 2016 | 27176815 |
| in vitro evaluation of excess copper affecting seedlings and their biochemical characteristics in carthamus tinctorius l. (variety pbns-12). | the present study was focused to recognize the changes in the safflower (carthamus tinctorius l. variety pbns-12), when exposed to different concentration of copper (25, 50 and 100 μm) along with control (0.5 μm) for 10 and 20 days. this experiment used hoagland's nutrient solution to meet the external nutrient conditions, which includes micro and macronutrients equivalent to soil solution with copper sulphate (cuso4. 5h2o) as a metal stress. the plant samples were harvested after 10 and 20 days ... | 2016 | 27186026 |
| production and characterisation of reduced-fat and pufa-enriched burrata cheese. | burrata is an italian fresh 'pasta filata' cheese made from cow's milk and cream that is rapidly spreading in europe. it has very high caloric content, and a technological protocol was developed for producing a reduced-fat type and fortifying it with polyunsaturated fatty acids (pufa) of vegetable origin. a satisfactory reduced-fat prototype was obtained by using a 14% fat cream, which was specifically developed by diluting double cream with a suspension of carob seed flour. the composition of t ... | 2016 | 27210495 |
| genetic mapping of millions of snps in safflower (carthamus tinctorius l.) via whole-genome resequencing. | accurate assembly of complete genomes is facilitated by very high density genetic maps. we performed low-coverage, whole-genome shotgun sequencing on 96 f6 recombinant inbred lines (rils) of a cross between safflower (carthamus tinctorius l.) and its wild progenitor (c. palaestinus eig). we also produced a draft genome assembly of c. tinctorius covering 866 million bp (∼two-thirds) of the expected 1.35 gbp genome after sequencing a single, short insert library to ∼21 × depth. sequence reads from ... | 2016 | 27226165 |
| the mechanism by which safflower yellow decreases body fat mass and improves insulin sensitivity in hfd-induced obese mice. | safflower yellow (sy) is the main effective ingredient of carthamus tinctorius l. it has been reported that sy plays an important role in anti-inflammation, anti-platelet aggregation, and inhibiting thrombus formation. in present study, we try to investigate the effects of sy on body weight, body fat mass, insulin sensitivity in high fat diet (hfd)-induced obese mice. | 2016 | 27242533 |
| molecular characterization of flavanone 3-hydroxylase gene and flavonoid accumulation in two chemotyped safflower lines in response to methyl jasmonate stimulation. | among secondary metabolites, flavonoids are particularly crucial for plant growth, development, and reproduction, as well as beneficial for maintenance of human health. as a flowering plant, safflower has synthesized a striking variety of flavonoids with various pharmacologic properties. however, far less research has been carried out on the genes involved in the biosynthetic pathways that generate these amazing flavonoids, especially characterized quinochalcones. in this study, we first cloned ... | 2016 | 27286810 |
| effects of extracts and isolated compounds from safflower on some index of promoting blood circulation and regulating menstruation. | carthamus tinctorius is used as one of the traditional chinese medicine (tcm) materials in prescriptions and composite to promote blood circulation to remove blood stasis, regulate menstruation and alleviate pain for over 2500 years. modern pharmacological experiments have demonstrated that safflower has wide-reaching biological activities, including dilating coronary artery, modulating immune system, improving myocardial ischemia, anticoagulation and thromboprophylaxis, antioxidation, antihypox ... | 2016 | 27286914 |
| radionuclides: accumulation and transport in plants. | application of radioactive elements or radionuclides for anthropogenic use is a widespread phenomenon nowadays. radionuclides undergo radioactive decays releasing ionizing radiation like gamma ray(s) and/or alpha or beta particles that can displace electrons in the living matter (like in dna) and disturb its function. radionuclides are highly hazardous pollutants of considerable impact on the environment, food chain and human health. cleaning up of the contaminated environment through plants is ... | 2017 | 27300012 |
| rapid fingerprint analysis of flos carthami by ultra-performance liquid chromatography and similarity evaluation. | flos carthami (fc), the dried flower of carthamus tinctorius l., has widely been used for the treatment of cardiovascular diseases in china. a rapid fingerprint analysis method of fc was established by ultra-performance liquid chromatography (uplc) for the quality control. the analysis time was shortened by 45 min, from 75 min on conventional high-performance liquid chromatography (hplc) to 30 min on uplc. ten batches of fc samples from various sources were analyzed by the uplc method. coexistin ... | 2016 | 27377888 |
| expression patterns of three ugt genes in different chemotype safflower lines and under meja stimulus revealed their potential role in flavonoid biosynthesis. | safflower (carthamus tinctorius l.) has received a significant amount of attention as a medicinal plant in china. flavonoids are the dominant active medical compounds. udp-glycosyltransferase plays an essential role in the biosynthesis and storage of flavonoids in safflower. in this study, 45 ugt unigenes were screened from our transcriptomic database of safflower. among them, 27 ugt unigenes were predicted to own a complete open reading frame with various pi and mw. the phylogenetic tree showed ... | 2016 | 27391785 |
| superoxide-scavenging and tyrosinase-inhibitory activities of the extracts of some chinese medicines. | the superoxide-scavenging and the tyrosinase-inhibitory activities of 28 kinds of plants used as chinese medicines were evaluated. methanol/water extracts were used for the screening tests, and for those which represented high activities, other kinds of extracts were also studied. the extracts of mallotus japonicus muell. arg. scavenged superoxide strongly; the half-inhibiting concentration (ic50) of its 50% methanol/water extract was 10.57 μg of dried material in 1 ml of reaction mixture. the e ... | 1997 | 27396888 |
| hydroxysafflor yellow a inhibits tgf-β1-induced activation of human fetal lung fibroblasts in vitro. | hydroxysafflor yellow a (hsya) is one of the chemical component isolated from chinese medicine carthamus tinctorius l. our preliminary study confirmed that hsya attenuated bleomycin-induced pulmonary fibrosis in mice. in this study, we evaluated the effect of hsya on tgf-β1-induced activation of human fetal lung fibroblasts (mrc-5) and explored the underlying mechanisms of its activity. | 2016 | 27457091 |
| cloning and functional analysis of three chalcone synthases from the flowers of safflowers carthamus tinctorius. | the flowers of safflowers (carthamus tinctorius l.) are very important as they are the sole source of their distinct pigments, i.e. carthamus-red and -yellows, and have historically had strong connections to the cultural side of human activities such as natural dyes, rouge, and traditional medicines. the distinct pigments are quinochalcone c-glucosides, which are found specifically in the flowers of c. tinctorius. to investigate the biosynthetic pathways of quinochalcone c-glucosides, de novo as ... | 2016 | 27534116 |
| first record of euphoria lurida fabricius (coleoptera: scarabaeidae) injurious to safflower (carthamus tinctorius l.) (asterales: asteraceae) in brazil. | we present the first report on euphoria lurida (fabricius) (coleoptera: scarabaeidae) infestation on safflower (carthamus tinctorius l.), a crop of industrial and medicinal importance. between september and october 2013-2015 in paraná state, we observed e. lurida adults feeding on safflower plants from the inception of flower head formation onwards, over an area of approximately 400 m(2). losses in the productivity of infested plants were estimated between 15 and 50%. the damage was characterize ... | 2017 | 27553719 |
| neuroprotective effects of a standardized flavonoid extract from safflower against a rotenone-induced rat model of parkinson's disease. | parkinson's disease (pd) is a major age-related neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra par compacta (snpc). rotenone is a neurotoxin that is routinely used to model pd to aid in understanding the mechanisms of neuronal death. safflower (carthamus tinctorius. l.) has long been used to treat cerebrovascular diseases in china. this plant contains flavonoids, which have been reported to be effective in models of neurodegenerative disease. ... | 2016 | 27563865 |
| hydroxysafflor yellow a exerts antioxidant effects in a rat model of traumatic brain injury. | free radical-induced oxidative damage occurs rapidly and is of primary importance during the secondary pathophysiological cascades of traumatic brain injury (tbi). hydroxysafflor yellow a (hsya) is a constituent of the flower petals of carthamus tinctorius (safflower) and may represent a potential therapeutic strategy to improve outcomes following tbi. the present study aimed to identify hsya in the brain tissues of rats exposed to tbi to determine its absorption and to investigate the underlyin ... | 2016 | 27599591 |
| volatile oxidation compounds and stability of safflower, sesame and canola cold-pressed oils as affected by thermal and microwave treatments. | the goal of this study was to investigate the effect of heating and microwave treatment on the levels of volatile oxidation products and the stability of safflower (carthamus tinctorius l.), sesame (sesamum indicum) and canola (brassica napus l.) cold-pressed oils. cold-pressed oils were subjected to conventional heating (oven test) using air-forced oven at 60°c and microwave heating for 2 and 4 min. the changes in conjugated diene (cd) and conjugated triene (ct) values were monitored during tre ... | 2016 | 27725480 |
| hydroxysafflor yellow a alleviates myocardial ischemia/reperfusion in hyperlipidemic animals through the suppression of tlr4 signaling. | hyperlipidemia aggravates myocardial ischemia/reperfusion (mi/r) injury through stimulating excessive inflammatory response. therefore, blockade of inflammatory signal is a potential therapeutic management for mi/r complicated with hyperlipidemia. hydroxysafflor yellow a (hsya, a monomer extracted from carthamus tinctorius l.), was studied in this article to address that the regulation of inflammatory signal would alleviate mi/r combined with hyperlipidemia injury. high-fat diet induced hyperlip ... | 2016 | 27731393 |
| carthorquinosides a and b, quinochalcone c-glycosides with diverse dimeric skeletons from carthamus tinctorius. | two novel quinochalcone c-glycosides, carthorquinosides a (1) and b (2), were isolated from the florets of carthamus tinctorius. their structures, including the absolute configurations, were established by analysis of nmr and ms data, together with chemical degradation and electronic circular dichroism spectra. compound 1 has an unprecedented quinochalcone-flavonol structure linked via a methylene bridge, and compound 2 comprises two glucopyranosylquinochalcone moieties linked via the formyl car ... | 2016 | 27748595 |
| in vitro study on anti-hepatitis c virus activity of spatholobus suberectus dunn. | hepatitis c virus (hcv) infects 200 million people worldwide, and 75% of hcv cases progress into chronic infections, which consequently cause cirrhosis and hepatocellular carcinoma. hcv infection is treated with currently considered standard drugs, including direct anti-viral agents (daas), alone or in combination with peginterferon-α plus ribavirin. however, sustained viral responses vary in different cohorts, and high costs limit the broad use of daas. in this study, the ethanol and water extr ... | 2016 | 27754461 |
| effects of dietary administration of rose hip and safflower on growth performance, haematological, biochemical parameters and innate immune response of beluga, huso huso (linnaeus, 1758). | the aim of this study was to investigate effects of two dietary medicinal herbs, rose hip (rosa canina) and safflower (carthamus tinctorius) supplementation on growth performance, haematological, biochemical parameters and innate immune response of in juvenile beluga, huso huso. fish (26.3 ± 0.4 g) were allocated into 15 tanks (20 fish per tank) and triplicate groups were fed a control diet or diets containing 1% and 2% of medicinal herbs, respectively. feed conversion ratio (fcr), specific grow ... | 2016 | 27773731 |
| safflower yellow prevents pulmonary metastasis of breast cancer by inhibiting tumor cell invadopodia. | carthamus tinctorius l. is a traditional chinese medicine that activates blood circulation and dissipates blood stasis, and has been extensively used as antitumor treatment in a clinical setting in single or in compound preparation form. however, empirical evidence and a better understanding of the possible mechanisms involved are still required. here, we investigated the role of safflower yellow (sy), the active ingredient of c. tinctorius, in the pulmonary metastasis of breast cancer, and the ... | 2016 | 27776431 |
| utilization of molecular, phenotypic, and geographical diversity to develop compact composite core collection in the oilseed crop, safflower (carthamus tinctorius l.) through maximization strategy. | safflower (carthamus tinctorius l.) is a dryland oilseed crop yielding high quality edible oil. previous studies have described significant phenotypic variability in the crop and used geographical distribution and phenotypic trait values to develop core collections. however, the molecular diversity component was lacking in the earlier collections thereby limiting their utility in breeding programs. the present study evaluated the phenotypic variability for 12 agronomically important traits durin ... | 2016 | 27807441 |
| comparative analysis of the effects of hydroxysafflor yellow a and anhydrosafflor yellow b in safflower series of herb pairs using prep-hplc and a selective knock-out approach. | the flower of carthamus tinctorius l. (carthami flos, safflower), important in traditional chinese medicine (tcm), is known for treating blood stasis, coronary heart disease, hypertension, and cerebrovascular disease in clinical and experimental studies. it is widely accepted that hydroxysafflor yellow a (hsya) and anhydrosafflor yellow b (asyb) are the major bioactive components of many formulae comprised of safflower. in this study, selective knock-out of target components such as hsya and asy ... | 2016 | 27827969 |
| safflower (catharmus tinctorius l.) oil supplementation in overnourished rats during early neonatal development: effects on heart and liver function in the adult. | carthamus tinctorius l. (common name: safflower) is an herb whose extracted oil (safflower oil) has been employed in both alternative and conventional medicine in the treatment of disease. overnutrition during early postnatal life can increase the lifetime risk of obesity and metabolic syndrome. here we investigate the effect of safflower oil supplementation given during a critical early developmental stage on the eventual occurrence of metabolic disease in overnourished rats. groups of overnour ... | 2016 | 27863203 |
| hydroxysafflor yellow a promotes angiogenesis via the angiopoietin 1/ tie-2 signaling pathway. | the flowers of carthamus tinctorius l. are widely used in traditional chinese medicine to treat cerebrovascular and cardiovascular diseases. hydroxysafflor yellow a (hsya), the main constituent of c. tinctorius l. flowers, is known for its multiple biological activities. the present study investigated the effects of hsya on angiogenesis in vitro and in a mouse hindlimb ischemia model. | 2016 | 27894114 |
| hydroxysafflor yellow a cardioprotection in ischemia-reperfusion (i/r) injury mainly via akt/hexokinase ii independent of erk/gsk-3β pathway. | hydroxysafflor yellow a (hsya) is the main active component of carthamus tinctorius l which has been used for hundreds of years in chinese folk medicine in the treatment cardiovascular disease. this study was designed to investigate whether hsya exerts cardioprotection in ischemia-reperfusion (i/r) injury heart and the mechanisms involved. the protective effect and mechanisms in myocardial ischemia reperfusion injury of hsya was evaluated by hypoxia-recover (h/r) injury cell model which induced ... | 2017 | 28068632 |
| carthamus tinctorius l. ameliorates brain injury followed by cerebral ischemia-reperfusion in rats by antioxidative and anti-inflammatory mechanisms. | carthamus tinctorius l. (ct) or safflower is widely used in traditional chinese medicine. this study investigated the effects of ct extract (cte) on ischemia-reperfusion (i/r) brain injury and elucidated the underlying mechanism. | 2016 | 28096971 |
| luhong formula inhibits myocardial fibrosis in a paracrine manner by activating the gp130/jak2/stat3 pathway in cardiomyocytes. | luhong formula (lhf)-a traditional chinese medicine containing cervus nippon temminck, carthamus tinctorius l., cinnamomum cassia presl, codonopisis pilosula( franch.) nannf., astragalus membranaceus ( fisch.) bge. var. mongholicus ( bge.) hsiao, lepidium apetalum willd-is used in the treatment of heart failure. | 2017 | 28115285 |
| hydroxysafflor yellow a alleviates lipopolysaccharide-induced acute respiratory distress syndrome in mice. | hydroxysafflor yellow a (hsya) is an effective ingredient of the chinese herb carthamus tinctorius l. the present study investigated the protective effect of hsya on lipopolysaccharide (lps)-induced acute respiratory distress syndrome in mice, and the underlying mechanisms involved. hsya (14, 28, 56 mg/kg) was intraperitoneally injected to mice once daily from day 1 to 10 after lps administration. hsya attenuated the body weight loss, the augmented left index and the increase of pathologic chang ... | 2017 | 28154251 |
| effect of unconventional oilseeds (safflower, poppy, hemp, camelina) on in vitro ruminal methane production and fermentation. | dietary supplementation with oilseeds can reduce methane emission in ruminants, but only a few common seeds have been tested so far. this study tested safflower (carthamus tinctorius), poppy (papaver somniferum), hemp (cannabis sativa), and camelina (camelina sativa) seeds in vitro using coconut (cocos nucifera) oil and linseed (linum usitatissimum) as positive controls. | 2017 | 28188639 |
| evaluation of the sub-chronic toxicity of a standardized flavonoid extract of safflower in rats. | carthamus tinctorius l., or safflower, is an annual herbaceous crop belonging to the family asteraceae, which is cultivated throughout china and used as a traditional chinese medicine. our previous study revealed anti-parkinson's disease effects of an isolated standardized safflower flavonoid extract (safe). the purpose of this study is to evaluate the potential sub-chronic toxicity of safe. male and female sprague dawley rats received three doses of safe (100, 300, and 500 mg/kg) q.d. by gavage ... | 2017 | 28192173 |
| inhibition of cerebral ischemia/reperfusion injury-induced apoptosis: nicotiflorin and jak2/stat3 pathway. | nicotiflorin is a flavonoid extracted from carthamus tinctorius. previous studies have shown its cerebral protective effect, but the mechanism is undefined. in this study, we aimed to determine whether nicotiflorin protects against cerebral ischemia/reperfusion injury-induced apoptosis through the jak2/stat3 pathway. the cerebral ischemia/reperfusion injury model was established by middle cerebral artery occlusion/reperfusion. nicotiflorin (10 mg/kg) was administered by tail vein injection. cell ... | 2017 | 28250754 |
| an enhanced targeted identification strategy for the selective identification of flavonoid o-glycosides from carthamus tinctorius by integrating offline two-dimensional liquid chromatography/linear ion-trap-orbitrap mass spectrometry, high-resolution diagnostic product ions/neutral loss filtering and liquid chromatography-solid phase extraction-nuclear magnetic resonance. | targeted identification of potentially bioactive molecules from herbal medicines is often stymied by the insufficient chromatographic separation, ubiquitous matrix interference, and pervasive isomerism. an enhanced targeted identification strategy is presented and validated by the selective identification of flavonoid o-glycosides (fogs) from carthamus tinctorius. it consists of four steps: (i) enhanced separation and detection by offline two-dimensional liquid chromatography/ltq-orbitrap ms (of ... | 2017 | 28256254 |
| molecular dynamics simulation integrating the inhibition kinetics of hydroxysafflor yellow a on α-glucosidase. | inhibition of α-glucosidase has attracted the attention of researchers due to its connection to type-2 diabetes. hydroxysafflor yellow a (hsya) extracted from carthamus tinctorius l. is a natural antioxidant used in traditional chinese medicine. in this study, the effect of hsya on α-glucosidase was evaluated using inhibitory kinetics based on the antioxidant properties of hsya and by performing computational simulation integration methods. hsya reversibly inhibited α-glucosidase in a competitiv ... | 2017 | 28264629 |
| antioxidant activities of aqueous extracts from 12 chinese edible flowers in vitro and in vivo. | the antioxidant function of edible flowers have attracted increasing interest. however, information is lacking on the impact of edible flowers on oxidative injury including hypoxia-re-oxygenation and hyperlipidemia. the antioxidant activities of aqueous extracts from 12 chinese edible flowers were assessed in four different antioxidant models, including total antioxidant capacity (tac), oxygen radical absorbance capacity (orac), scavenging hydroxyl radical capacity (shrc) and scavenging superoxi ... | 2017 | 28326000 |
| parameters influencing agrobacterium-mediated transformation system in safflower genotypes aks-207 and pkv pink. | shoot regeneration in safflower (carthamus tinctorius 'aks 207' and 'pkv pink') genetically transformed using agrobacterium was used for assessing various constraints to the efficiency of transformation including infection period, virulence induction medium, co-cultivation period, bacterial titre, selection regime, and the natural phenolic compound acetosyringone. transformation frequency was promising with 8-10-day-old cotyledonary leaf explants. therefore, explants of that age cultured on agro ... | 2016 | 28330253 |
| novel quantitative real-time pcr approach to determine safflower (carthamus tinctorius) adulteration in saffron (crocus sativus). | this work intended to develop dna-based methods to detect and quantify safflower as an adulterant in saffron. species-specific pcr and real-time pcr with evagreen dye targeting the its region of carthamus tinctorius l. (safflower) were successfully proposed. the assays allowed absolute and relative sensitivities of 2pg of safflower dna (∼1.4 dna copies) and 0.1% of safflower in saffron (crocus sativus l.), respectively. a normalised real-time pcr approach was also proposed in the range of 0.1-20 ... | 2017 | 28372231 |