Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| prevalence of drug resistance in dharmapuri and a. pallipatti areas of tamil nadu. | an evaluation of leprosy control project was undertaken in dharmapuri and a. pallipatti areas of tamil nadu to study the prevalence rate of drug resistance among the leprosy patients. at the end of 5 years of assessment 266 patients were still found to be bacteriologically positive among whom 25 patients were suspected to be clinically dapsone resistant. by mouse foot pad technique the drug resistant prevalence rate was found to be 1.1 per cent in these two areas. | 1985 | 3908580 |
| viability of mycobacterium leprae within the gut of aedes aegypti after they feed on multibacillary lepromatous patients: a study by fluorescent and electron microscopes. | 1985 | 3908862 | |
| suppression of mycobacterium leprae-induced leucocyte migration inhibition following lepromin injection in healthy contacts of leprosy. preliminary observations. | 1985 | 3908863 | |
| vaccines against mycobacteria and other intracellular multiplying bacteria. | as the prototype of a vaccine against mycobacterial infection, the bcg (bacille bilié calmette et guérin) has been used against tuberculosis for more than 60 years. it is the only live attenuated vaccine used on humans in more than 182 countries or territories in the world, and very few changes have been made in its fabrication and distribution, except for the production of lyophilized seed-lots. however, its history is marked with controversies concerning its innocuity and efficacy. while bcg s ... | 1985 | 3909929 |
| production of monoclonal antibodies against mycobacterium leprae and armadillo-derived mycobacteria. | six monoclonal antibodies to mycobacterium leprae and armadillo-derived mycobacteria were produced. the monoclonal antibodies were characterized by an immunofluorescence assay using 22 mycobacterial strains. one monoclonal antibody, f47-21-3, reacted only with m. leprae; two, f45-9 and f45-15, reacted only with two armadillo-derived mycobacterial strains. these six monoclonal antibodies can be used for the identification of m. leprae and armadillo-derived mycobacteria. | 1985 | 3909933 |
| the allyl group for protection in carbohydrate chemistry. 17. synthesis of propyl o-(3,6-di-o-methyl-beta-d-glucopyranosyl)-(1----4)-o-(2,3- di-o-methyl-alpha-l-rhamnopyranosyl)-(1----2)-3-o-methyl-alpha- l-rhamnopyranoside: the oligosaccharide portion of the major serologically active glycolipid from mycobacterium leprae. | allyl 4-o-benzyl-alpha-l-rhamnopyranoside was converted into allyl 4-o-benzyl-3-o-methyl-alpha-l-rhamnopyranoside and this was condensed with 2,3,4-tri-o-acetyl-alpha-l-rhamnopyranosyl chloride to give a disaccharide derivative which was converted into allyl 4-o-benzyl-2-o-(2,3-o-isopropylidene-alpha-l-rhamnopyranosyl)-3-o-methyl -alpha- l-rhamnopyranoside. this disaccharide derivative was condensed with 2,4-di-o-acetyl-3,6-di-o-methyl-alpha-d-glucopyranosyl chloride to give a trisaccharide deri ... | 1985 | 3910287 |
| determination of antibodies in dried blood from earlobes of leprosy patients by enzyme-linked immunosorbent assay--a preliminary report. | an enzyme-linked immunosorbent assay (elisa) was used with soluble antigens of mycobacterium leprae. all blood samples collected from the earlobes of 109 leprosy patients and 100 healthy controls (from a non-endemic area of leprosy) were absorbed with m. vaccae, bcg, cardiolipin, and lecithin according to the technology of the fla-abs test before being tested in the elisa. the results (at a 1:200 blood dilution) showed that antibody activity gradually increased from tt to ll (mean od values: tt ... | 1985 | 3910746 |
| electron microscopic observations of acid-fast bacilli in nasal mucosal biopsies of lepromatous leprosy patients. | the fine structure of acid-fast bacilli in nasal mucosal lepromas of lepromatous leprosy patients was studied in ultrathin sections by the electron microscope. the cell envelope of the bacilli was the main point of these observations. the electron microscopic examination of some of the bacilli revealed the envelope to be multilaminate. some of the cellular matter was filled with an electron-less-dense, amorphous substance, surrounded with a membrane-like structure, and was adherent to the outerm ... | 1985 | 3910747 |
| an experimental study of the antileprosy activity of a series of thioamides in the mouse. | a series of substituted thioamides have been studied to establish whether their structure-activity pattern against mycobacterium leprae is similar to that displayed against m. tuberculosis. antileprosy activity was evaluated in the mouse foot pad using both the kinetic and continuous methods. ethionamide and prothionamide were found to be the most active compounds and to be of approximately equal potency. thioisonicotinamide was about five times less active. 2-t-butyl-thioisonicotinamide, 2-dime ... | 1985 | 3910748 |
| experimental reproduction of leprosy in seven-banded armadillos (dasypus hybridus). | four autochthonous seven-banded armadillos (dasypus hybridus) from argentina which developed disseminated leprosy are reported. the average time from inoculation to death was 14.6 months. acid-fast bacilli (afb) were found in the skin, nerves, spleen, lymph nodes, lungs, meninges, and striated muscle. several tests were used to prove that the afb found in the infected animals were mycobacterium leprae: a) failure to grow in standard culture media for mycobacteria, b) extraction of acid-fastness ... | 1985 | 3910749 |
| monoclonal antibodies and recombinant dna technology: present and future uses in leprosy and tuberculosis. | 1985 | 3910750 | |
| distribution of mycobacterium leprae in the circles of counting slides. | 1985 | 3910751 | |
| distribution of mycobacterium leprae in circular counting films. | 1985 | 3910752 | |
| recent trends in chemotherapy of leprosy. | 1985 | 3912375 | |
| the lack of therapeutic effects in mice of the combined gamma-irradiated mycobacterium leprae and viable bcg against mycobacterium leprae infection. | 1985 | 3913661 | |
| does the hansen bacillus harm or benefit the leprous patient? | 1985 | 3913662 | |
| primary dapsone resistance in leprosy. | 20 carefully selected untreated patients of bacilliferous leprosy were investigated for primary dapsone resistance by foot pad inoculation. mice were fed on 0.001 g% and 0.01 g% of dapsone during the period of study. mice in the control group were given normal rodent feed only. animals were sacrificed from 6 month onwards at 6 week intervals upto 9 months. in two animals the growth of m. leprae was not inhibited by 0.001 g% concentration of dapsone in diet, but was completely inhibited by 0.01 g ... | 1985 | 3913705 |
| dapsone resistance in north india. | an attempt has been made to screen the resistant strains of m. leprae in lepromatous patients from the eight northern states of india. by using the mouse foot pad technique it was found that in a total of 69 clinically suspected patients 33 (47.8%) harboured m. leprae with some degree of dapsone resistance. a detailed epidemiological study in these parts of the country may reveal the prevalence rate. | 1985 | 3913706 |
| levels of the third component of complement in mycobacterium leprae infected intact and immune compromised mice. | normal and immunosuppressed mice were infected with mycobacterium leprae and the bacillary counts were made from the footpads at 3, 6 and 9 months post inoculation. a decrease in the serum c3 level was observed in the infected groups of animals compared to controls. | 1985 | 3913707 |
| measurement of atp generation and decay in mycobacterium leprae in vitro. | the intracellular atp content of mycobacterium leprae isolated from armadillo tissue was approximately 1.5 x 10(-16) g per bacillus. during in vitro incubation of bacilli at 4 degrees c, 33 degrees c or 37 degrees c there was an exponential decrease in atp content, the rate depending on the medium and the temperature. m. leprae incorporated phosphate into atp and into other nucleotide materials during in vitro incubation. | 1985 | 3913745 |
| transmission of leprosy in nude mice. | nude mice in groups of 10 were exposed to m. leprae by subcutaneous injection and topically through the nose, lungs, mouth, stomach and skin, broken and unbroken. animals injected subcutaneously and those topically exposed to m. leprae through the nose developed localized disease which in the course of time became generalized. the nose seems to be the site of entry of m. leprae in this model. to the extent that these results can be generalized to humans exposed to m. leprae, it would seem that l ... | 1985 | 3914846 |
| effect of repeated lepromin testing on experimental nine-banded armadillo leprosy. | twenty-eight armadillos were lepromin tested and infected with m. leprae; 18 intravenously and 10 intradermally. the lepromin test was repeated after 3 months and at intervals of 6 months thereafter until their death or sacrifice up to 30 months. the one animal with tuberculoid lepromin was resistant and 14 of the 16 with lepromatous lepromin developed generalized disease. of the 11 with borderline lepromin, 6 developed disseminated disease and 5 were resistant. there is a definite relationship ... | 1985 | 3915005 |
| growth of mycobacterium leprae in a redox system: ii. further improvements in the system and growth efficiency. | improvement of the redox system for growth of m. leprae as brought about by modification in the concentration and mode of preparation of individual media constituents, and by addition of newer substances, is being reported. a structural modification in the construction of the thunberg's tubes and flasks that are used as culture vessels, has been introduced for ease of handling. vitamin e (alpha-tocopherol) has been found to be useful. concentrations of liposomes and gelatin in the medium could b ... | 1985 | 3915006 |
| computerized mathematical model of m. leprae population dynamics during multiple drug therapy. | a computerized mathematical model of m. leprae populations during multiple drug therapy (mdt) was constructed. relevant published information available to date was fed into it, and reasoned assumptions were made. from the model, it seems likely that mdt steadily selects bacteria resistant to the most powerful of the three drugs used: unless the individual bactericidal potencies of the drugs balance one another. if the drugs used have differing potencies, cure probably hinges on treatment being c ... | 1985 | 3915007 |
| studies on healthy contacts of leprosy patients--a preliminary report. | 91 healthy contacts of leprosy patients were studied for subclinical infection and possibly the pre-clinical stage of the disease using a battery of tests. it was observed that the test based on competitive inhibition of monoclonal antibody binding to the my2 a determinant of m. leprae identifies a preclinical stage of the disease. | 1985 | 3915008 |
| involvement of tongue in leprosy. | 1985 | 3915009 | |
| [immunological study of the easter island population to detect hansen's infection]. | 1985 | 3915139 | |
| [electron microscopic findings in peripheral nerve lesions of nude mouse inoculated with m. leprae--perineural lesion]. | 1985 | 3915747 | |
| [inoculation of mycobacterium leprae into beige mice]. | 1985 | 3916295 | |
| experimental leprosy in three species of monkeys. | eleven mangabey monkeys inoculated with mycobacterium leprae developed lepromatous-type leprosy. nine of the mangabeys were inoculated with m. leprae isolated from a mangabey with naturally acquired lepromatous leprosy. immune function was depressed in some of these animals after dissemination of the disease. two mangabeys developed lepromatous leprosy after inoculation with human m. leprae passaged in an armadillo. three rhesus and three african green monkeys inoculated with mangabey-derived m. ... | 1985 | 3917577 |
| hla class-ii immune response genes and products in leprosy. | 1985 | 3918314 | |
| fixation of mycobacterium leprae in unstained smears prior to shipment or storage: evaluation of formaldehyde using mycobacterium tuberculosis as indicator of efficacy. | 1985 | 3920468 | |
| antibody response to phenolic glycolipid i in inbred mice immunized with mycobacterium leprae. | the level of circulating antibody to phenolic glycolipid i of mycobacterium leprae was determined in 18 inbred strains of mice after immunization with m. leprae organisms. by using a solid-phase radioimmunoassay with phenolic glycolipid i as test antigen, a continuous distribution of antibody levels ranging from high to low was observed. the level was found to be controlled by multiple genes, including both h-2 complex- and igh allotype complex-linked genes. low antibody response to phenolic gly ... | 1985 | 3921463 |
| ultrastructural aspects of oral and facial lepromatous lesions. | the ultrastructure of 10 lepromatous lesions in the face and the palatal mucosa after different duration and length of treatment was studied. biopsies taken from patients who showed erythema nodosum leprosum (enl) revealed different ultrastructural characteristics from those taken from 'burnt out' and non-medicated cases. multiple secondary lysosomes were rarely seen in non-enl cases. the presence of mycobacterium leprae and an increased lysosomal activity in enl reactive cases is interpreted as ... | 1985 | 3921481 |
| detection of an antigen (my4) common to m. tuberculosis and m. leprae by 'tandem' immunoassay. | a novel 'tandem' immunoassay for the detection of mycobacterial antigen was devised using a monoclonal antibody (ml 34) both as solid phase 'capture' and as the 125i- or enzyme-labelled 'tracer' antibody. this antibody binds to the repeating epitopes (my4b) of a water-soluble protease-resistant antigen from m. tuberculosis, m. leprae and some other species of mycobacteria. optimal binding results could be obtained within 4 h by the consecutive incubation of ml34-coated microtitre plates with ant ... | 1985 | 3923119 |
| epidemiology of leprosy in relation to control. report of a who study group. | 1985 | 3925646 | |
| periodic acid-schiff reaction stains mycobacterium tuberculosis, mycobacterium leprae, mycobacterium ulcerans, mycobacterium chelonei (abscessus), and mycobacterium kansasii. | 1985 | 3925927 | |
| characterization of the specificity of monoclonal antibodies against mycobacterium tuberculosis by crossed immunoelectrophoresis. | the specificity of monoclonal antibodies against mycobacterium tuberculosis was determined by crossed immunoelectrophoresis. radiolabelled, non-precipitating monoclonal antibody was incorporated in the top gel together with unlabelled polyvalent, precipitating anti-bacillus calmette-guérin (bcg) antibody. inclusion of labelled antibody in individual precipitate lines was demonstrated by autoradiography. each monoclonal antibody was localized in a single precipitate line: antibody tb73 reacted wi ... | 1985 | 3927476 |
| a series of new antileprosy compounds derived from serotonin. | 1985 | 3927649 | |
| immunity to leprosy. ii. genetic control of murine t cell proliferative responses to mycobacterium leprae. | t cell proliferative responses to mycobacterium leprae were measured after immunization of mice at the base of the tail with antigen and challenging lymphocytes from draining lymph nodes in culture with m. leprae. this t cell response to m. leprae has been compared in 18 inbred strains of mice. c57bl/10j mice were identified as low responder mice. the congenic strains b10.m and b10.q were found to be high responders, whereas b10.br and b10.p were low responders. f1 (b10.m x c57bl/10j) and f1 (b1 ... | 1985 | 3928757 |
| an analysis of in vitro t cell responsiveness in lepromatous leprosy. | in lepromatous leprosy, there is extensive replication of mycobacterium leprae (m. leprae) within dermal macrophages. this lack of microbial resistance has been attributed to a defective cell-mediated immune response to m. leprae antigens. we have examined the in vitro response of t cells to m. leprae to determine if hyporesponsiveness could be reversed. the study included 40 unselected patients from new york and from colombia, most with the severe lepromatous form of the disease. we first noted ... | 1985 | 3928804 |
| temperature-induced changes in viability, diphenoloxidase and permeability of mycobacterium leprae. | among mycobacteria secretion of the enzyme diphenoloxidase has been established as a property of mycobacterium leprae. the antileprosy drug dapsone (dds), which completely inhibits the enzyme from plant and mammalian sources, does not readily penetrate intact m. leprae. when the drug is complexed with polylysine, it easily permeates the bacteria and produces 100% inhibition of its diphenoloxidase, suggesting a permeability barrier of the cytoplasmic membrane of m. leprae to dapsone. in this stud ... | 1985 | 3929029 |
| [towards a vaccine against leprosy]. | 1985 | 3933117 | |
| a possible metabolic role for o-diphenoloxidase in mycobacterium leprae. | among mycobacteria, mycobacterium leprae is unique in its ability to oxidize a variety of diphenols to quinones in vitro. what physiologic role o-diphenoloxidase has in the organism remained unknown. reducing substrates like nadph, nadh and ascorbic acid reacted with the quinone formed from dopa (3,4-dihydroxyphenylalanine); the substrates were oxidized and the quinone was reduced back to diphenol in the process. since the quinone undergoes reversible oxidation-reduction, diphenoloxidase might s ... | 1985 | 3935479 |
| leucocyte migration inhibition response of mycobacterium habana with sensitized animals and cells from leprosy patients. | response of mycobacterium habana sensitized mouse cells against habanin (sonicated extract) lepromin (dharmendra) and tuberculin has been studied in the leucocyte migration inhibition test. the homologous antigenic response has evoked maximum inhibition as compared to heterologous antigens but close antigenic association has also been observed with lepromin and tuberculin. with human cells from leprosy patients these antigens have evoked analogous response indicating cross immunogenicity of m. h ... | 1985 | 3935726 |
| the role of interleukin-2 (il-2) in the specific unresponsiveness of lepromatous leprosy to mycobacterium leprae: studies in vitro and in vivo. | the role of il-2 in the immunological deficiency of lepromatous leprosy patients towards mycobacterium leprae have been studied further. after initial stimulation with m. leprae + il-2, lepromatous lymphocytes could be restimulated with m. leprae alone. the specificity of the responses obtained varied. some patients gave a stronger response to bcg as compared to m. leprae, while in others a stronger response to m. leprae as compared to bcg was obtained. studies of the composition of lymphocytes ... | 1985 | 3936783 |
| epidemiology of leprosy in relation to control (who technical report series no. 716 of 1985). part i. | 1985 | 3938985 | |
| a culture medium for cultivation of mycobacteria, probably mycobacterium leprae from mycobacterium leprae infected tissues. | mycobacterium leprae suspensions were prepared from infected armadillos. the m. leprae cells were inoculated into culture media containing kh2po4 4.7. g. na2hpo4 2 g, sodium thioglycolate 1 g, (nh4)2so4 2 g, mgso4 0.1 g, ferric ammonium citrate 0.05 g, and lipoic acid (thioctic acid) 0.1 g in one liter distilled water. the solution was enriched with heat killed, sonicated leprosy derived mycobacterium x or crude mycobactin extract from m. phlei to contain + 0.2 micrograms mycobactin per 1 ml in ... | 1985 | 3938986 |
| [lysosome and leprosy bacilli]. | 1985 | 3939304 | |
| cross-reactivity of antigens from the cytoplasm and cell walls of some corynebacteria and mycobacteria. | leprosy-derived corynebacteria (ldc) are non-acid-fast organisms isolated from leprosy lesions in humans. in this study 20 antigens of native ldc cytoplasm were identified by immunoelectrophoresis, and autoclaving yielded the m1 component, which strongly cross-reacted with antigen 60 of mycobacterium bovis bcg (bacille calmette-guérin) and antigen 7 of mycobacterium leprae. the polysaccharide moiety of m1 was immunologically related to the ldc cell wall polysaccharide previously characterized as ... | 1985 | 3965589 |
| the mononuclear phagocyte system in granulomas. | a comparison is made between immunologically induced and non-immunologically induced granulomas in guinea-pigs injected with metals (zirconium and aluminum) or with mycobacteria (bcg vaccine and mycobacterium leprae). immunological granulomas were characterized by epithelioid cells and fibrosis, whereas non-immunological granulomas contained phagocytosing macrophages with little evidence of fibroblast activation. epithelioid cells carry the same specific macrophage antigen as phagocytosing macro ... | 1985 | 4015981 |
| biochemical alterations in the serum of armadillos (dasypus novemcinctus) infected with mycobacterium leprae. a preliminary report. | armadillos (dasypus novemcinctus) were inoculated with mycobacterium leprae isolated from lepromas taken from untreated lepromatous patients or from the spleen of an armadillo previously infected with human m. leprae. the effect of the infection on the serum levels of lactic dehydrogenase (ldh), alkaline phosphatase (alkp), glutamate-oxalacetate (got) and glutamate-pyruvate (gpt) transaminases was investigated. in general, there was a good correlation between positive evidences of infection and ... | 1985 | 4020215 |
| inappropriate responses to mycobacterium leprae infections--c reactive protein in man and serum amyloid p in mice. | in a study of c-reactive protein (crp) levels in the sera of 77 patients with leprosy, it was found that in the majority of newly diagnosed patients, the level was within the normal range for a healthy malaysian population. elevated levels did occur, but were usually found in patients with complications, and were more likely to occur in patients who had been receiving drug treatment for some time. this suggested that mycobacterium leprae infection by itself does not stimulate crp synthesis and c ... | 1985 | 4042426 |
| purification of phenolic glycolipid i from armadillo and human sources. | 1985 | 4045269 | |
| isolation of phenolic glycolipid i from human lepromatous nodules. | 1985 | 4045270 | |
| leprosy in children one year of age and under. | information obtained from a review of the literature, the united states armed forces institute of pathology files, and from a correspondence survey revealed a total of 91 infants one year of age and under in whom leprosy was diagnosed. biopsy confirmation was available on 19 infants, and in an additional 32 patients the diagnosis of leprosy was considered certain even though biopsy confirmation was not obtained. although the mother was probably the most common source of the infection (29 infants ... | 1985 | 4086915 |
| histology of the mitsuda reaction of healthy adults with no known contacts with leprosy patients. | mitsuda tests were performed on 100 healthy adult brazilian males unrelated consanguineously to leprosy patients and with no known contacts with this disease. three lepromatous patients served as negative mitsuda controls. the lepromin employed was from mycobacterium leprae-infected armadillo tissue prepared according to who standards. clinical response to the lepromin inoculation was graded according to the recommendations of the vi international leprosy congress held in madrid (1953). the hist ... | 1985 | 4086917 |
| a single skin lesion--an unusual presentation of lepromatous leprosy. | lepromatous leprosy presenting as a solitary lesion with a high bacterial count is a rare occurrence. such a case has been followed at the national hansen's disease center, carville, louisiana, u.s.a., since 1977. the lesion was located on the left elbow and had been present for about nine months. the bacterial index in the lesion was 5+ and the morphological index was 0%, but slit-skin smears elsewhere were negative. the histopathology of the lesion was that of subpolar lepromatous leprosy, and ... | 1985 | 4086919 |
| electron-transparent zone of mycobacteria may be a defence mechanism. | 1970 | 4097724 | |
| [immunologic specificity]. | 1970 | 4100053 | |
| elimination of the acid fastness but not the gram positivity of leprosy bacilli after extraction with pyridine. | bacilli from a number of tissues excised from cases of lepromatous and borderline leprosy, unlike mycobacteria, were found to lose their acid-fastness after treatment with pyridine. | 1971 | 4102336 |
| antileprosy drugs. | 1971 | 4104273 | |
| [misdiagnosed case of leprosy]. | 1970 | 4105519 | |
| prevention of leprosy. | 1971 | 4105673 | |
| immunological analysis of mycobacterium leprae using cross-reactions with cytoplasmic antigens of the actinomycetales. | 1972 | 4112239 | |
| attempts at the cultivation of m. leprae in cell-free, semi-synthetic soft agar media. | 1971 | 4112523 | |
| the morphological index. | 1971 | 4113655 | |
| stain techniques and the morphology of mycobacterium leprae. | 1971 | 4113656 | |
| modification of fite faraco staining for acid fast bacilli. | 1971 | 4113757 | |
| infection of murine striated muscle with mycobacterium leprae: a study by light and electron microscopy. | 1972 | 4113797 | |
| mechanisms of reactions in leprosy. | 1972 | 4115745 | |
| [demonstration of hansen's bacillus during neuritis in leprosy]. | 1972 | 4117525 | |
| immunochemical identification of a defined antigen of mycobacterium leprae. | an extract from purified mycobacterium leprae precipitated with sera from patients with tuberculosis, mycetoma, and leprosy and gave a band of identity with polysaccharide i from nocardia and mycobacteria. | 1972 | 4117882 |
| studies on the antigenic specificity of mycobacterium leprae. ii. purification and immunological characterization of the soluble antigen in leprosy nodules. | 1972 | 4119113 | |
| a simple method for the differentiation of mycobacterium leprae from other mycobacteria through routine staining technics. | 1972 | 4119114 | |
| application of nyka's method for the staining of mycobacteria in leprous skin sections. | 1973 | 4120112 | |
| cytochemical reactions of human leprosy bacilli and mycobacteria: ultrastructural implications. | leprosy bacilli harvested from freshly biopsied tissue from cases of lepromatous, borderline and histoid leprosy were, in conjunction with mycobacterium lepraemurium and representative mycobacteria, examined cytochemically with and without their pyridine-extractable acid-fastness. unlike the mycobacteria, unextracted leprosy bacilli failed to give a positive response to the periodic acid schiff test or to take up sudan black b, toluidine blue o, alkaline methylene blue or safranin o. once their ... | 1973 | 4120605 |
| comments on the chemotherapy of leprosy as influenced by present knowledge of mycobacterium leprae. | 1973 | 4120832 | |
| electron microscopic study of the morphologic index. | 1973 | 4126544 | |
| quantitative evaluation of the progress of intracellular infection in vitro: incorporation of 3h-thymidine into deoxyribonucleic acid by mycobacterium leprae in cultivated blood monocytes. | growth of intracellular parasites such as mycobacterium leprae in macrophages derived from human peripheral blood monocytes can be assessed by selective incorporation of [methyl-(3)h]thymidine into deoxyribonucleic acid of the bacterial cells. the radioactive precursor is not taken up by the host cells, and evidence has been presented for its incorporation into bacteria. the procedure is sensitive, reproducible, and highly quantitative. | 1974 | 4128631 |
| comparison of the modes of spread and the incidence of tuberculosis and leprosy. | 1974 | 4128836 | |
| effect of prior oxidation on the acid-fastness of mycobacteria. | 1973 | 4129032 | |
| letter: thalidomine neuropathy and leprous neuritis. | 1974 | 4129733 | |
| letter: culturing mycobacterium leprae in the dark. | 1974 | 4129740 | |
| leprosy-susceptibility testing of armadillos. 2. late cell and bacterial responses at inoculation site of living leprosy bacilli in 'resistant' armadillos. | 1973 | 4129797 | |
| advances in the microbiology of m. leprae in the past century. | 1973 | 4130571 | |
| immunologic studies on leprosy. 2. antigenic studies of mycobacterium leprae. | 1973 | 4131110 | |
| leprosy: confirmation in the armadillo. | bacteria isolated from lesions of lepromatoid leprosy in the armadillo were studied in comparison with mycobacterium leprae isolated directly from human lepromatous leprosy lesions. three methods were used to show that the bacteria from the lesions of the armadillo were identical to those of the human lesions: (i) extraction of the bacteria with pyridine and subsequent staining with various techniques, (ii) the competence in clearing bacilli (ccb) test, and (iii) the mitsuda test. | 1974 | 4133762 |
| intracellular growth of an obligatory parasite mycobacterium leprae. host bacterial interactions. | 1974 | 4135832 | |
| experimental chemotherapy in leprosy, then and now. | 1973 | 4136732 | |
| electron microscope study of erythema nodosum leprosum. | 1974 | 4137644 | |
| fluorescent staining for mycobacterium leprae in tissue sections. comparison with fite-faraco procedure. | 1974 | 4137671 | |
| morphological changes of mycobacterium leprae grown in mouse foot pads. | 1974 | 4140172 | |
| acid mucopolysaccharide metabolism in leprosy. 1. storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy. | a histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. in contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. the macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tube ... | 1974 | 4142476 |
| [effect of a uniform magnetic field on leukocytes. study of the leukocyte migration test in lepers]. | 1974 | 4142862 | |
| [microbiology of leprosy. behavior and staining affinities of hansen's bacillus in leprous lesions]. | 1974 | 4143388 | |
| occurrence of mycobacterium leprae in arthropods. | 1972 | 4146908 | |
| tenth international leprosy congress bergen, 1973. reports of committees. | 1974 | 4152479 | |
| [100 years of mycobacterium leprae]. | 1974 | 4154579 | |
| [a new staining method for mycobacteria in tissue sections]. | 1965 | 4158306 |