Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| rectal colonization by group b streptococcus as a predictor of vaginal colonization. | the purpose of this article was to describe rectal colonization by group b streptococcus (gbs) and its role in the prediction of vaginal colonization. | 2009 | 19371857 |
| a fluorescence-based opsonophagocytosis assay to measure the functional activity of antibody to group b streptococcus. | an in vitro assay designed to measure the functional activity of vaccine-induced antibody is a necessary component of any vaccine development program. because traditional efficacy studies of vaccines to prevent neonatal diseases caused by group b streptococcus (gbs) are unlikely given the effectiveness of current antibiotics and screen-based surveillance practices, the ability to efficiently and effectively measure functional antibody responses may be of particular importance. gbs, like other en ... | 2009 | 19377284 |
| impact of lgt mutation on lipoprotein biosynthesis and in vitro phenotypes of streptococcus agalactiae. | although streptococcus agalactiae, the group b streptococcus, is a leading cause of invasive neonatal disease worldwide the molecular basis of its virulence is still poorly understood. to investigate the role of lipoproteins in the physiology and interaction of this pathogen with host cells, we generated a mutant s. agalactiae strain (a909deltalgt) deficient in the lgt enzyme and thus unable to lipidate lipoprotein precursors (pro-lipoproteins). the loss of pro-lipoprotein lipidation did not aff ... | 2009 | 19383708 |
| scavenger receptors: role in innate immunity and microbial pathogenesis. | accumulating evidence shows that many scavenger receptors (sr), including sr-a, marco and cd36, represent an important part of the innate immune defence by acting as pattern-recognition receptors, in particular against bacterial pathogens. several sr are expressed on macrophages and dendritic cells, where they act as phagocytic receptors mediating non-opsonic phagocytosis of pathogenic microbes. another important function of some sr is to act as co-receptors to toll-like receptors (tlr), modulat ... | 2009 | 19388903 |
| n-acetylcysteine improves group b streptococcus clearance in a rat model of chronic ethanol ingestion. | sepsis is the most common risk factor associated with acute respiratory distress syndrome (ards) and results in a 40-60% mortality rate due to respiratory failure. furthermore, recent epidemiological studies have demonstrated that a history of alcohol abuse increases the risk of ards by 3.6-fold. more recently, group b streptococcus (gbs) infections in nonpregnant adults have been increasing, particularly in alcoholics where there is an increased risk of lobular invasion and mortality. we have s ... | 2009 | 19389194 |
| neonatal cord blood subsets and cytokine response to bacterial antigens. | we compared lymphocyte subsets and cytokine responses to bacteria among term, preterm infants, and adults. lymphocyte subset percentages in cord blood (22 preterm, 27 term neonates) and peripheral blood from 21 adults and cytokine/chemokine interleukin (il)-6, il-8, il-10, il-12, interferon gamma (ifn gamma) responses to escherichia coli, group b streptococcus (gbs), staphylococcus epidermidis, and lactobacillus plantarum (lp299v) were assessed by flow cytometry. preterm compared with term infan ... | 2009 | 19391080 |
| the group b streptococcal serine-rich repeat 1 glycoprotein mediates penetration of the blood-brain barrier. | group b streptococcus (gbs) is the leading cause of bacterial meningitis in newborn infants. because gbs is able to invade, survive, and cross the blood-brain barrier, we sought to identify surface-expressed virulence factors that contribute to blood-brain barrier penetration and the pathogenesis of meningitis. | 2009 | 19392623 |
| molecular dissection of the seca2 locus of group b streptococcus reveals that glycosylation of the srr1 lpxtg protein is required for full virulence. | in streptococci, the seca2 locus includes genes encoding the following: (i) the accessory sec components (seca2, secy2, and at least three accessory secretion proteins), (ii) two essential glycosyltranferases (gts) (gtfa and gtfb), (iii) a variable number of dispensable additional gts, and (iv) a secreted serine-rich lpxtg protein which is glycosylated in the cytoplasm and transported to the cell surface by this accessory sec system. the seca2 locus of streptococcus agalactiae strain nem316 is s ... | 2009 | 19395494 |
| surfome analysis as a fast track to vaccine discovery: identification of a novel protective antigen for group b streptococcus hypervirulent strain coh1. | safe recombinant vaccines, based on a small number of antigenic proteins, are emerging as the most attractive, cost-effective solution against infectious diseases. in the present work, we confirmed previous data from our laboratory showing that whole viable bacterial cell treatment with proteases followed by the identification of released peptides by mass spectrometry is the method of choice for the rapid and reliable identification of vaccine candidates in gram-positive bacteria. when applied t ... | 2009 | 19401597 |
| human streptococcus agalactiae isolate in nile tilapia (oreochromis niloticus). | streptococcus agalactiae, the lancefield group b streptococcus (gbs) long recognized as a mammalian pathogen, is an emerging concern with regard to fish. we show that a gbs serotype ia multilocus sequence type st-7 isolate from a clinical case of human neonatal meningitis caused disease and death in nile tilapia (oreochromis niloticus). | 2009 | 19402966 |
| [effectiveness of systematic investigation for group b streptococcus in urine samples to identify colonized pregnant women]. | to evaluate the effectiveness of systematic investigation for group b streptococcus (gbs) in urine samples to detect colonization in pregnant women. | 2009 | 19406522 |
| expression, purification, crystallization and preliminary crystallographic analysis of laminin-binding protein (lmb) from streptococcus agalactiae. | laminin-binding protein (lmb), a surface-exposed lipoprotein from streptococcus agalactiae (group b streptococcus), mediates attachment to human laminin and plays a crucial role in the adhesion/invasion of eukaryotic host cells. however, the structural basis of laminin binding still remains unclear. in the context of detailed structural analysis, the lmb gene has been cloned, expressed in escherichia coli, purified and crystallized. the crystals diffracted to a resolution of 2.5 a and belonged t ... | 2009 | 19407385 |
| capturing host-pathogen interactions by protein microarrays: identification of novel streptococcal proteins binding to human fibronectin, fibrinogen, and c4bp. | microbial pathogen entry and survival in the host is mediated by a network of molecular interactions between the two partners, which has been the subject of many research efforts. a complex picture is emerging in which host-pathogen crosstalk involves a high number of proteins, often with redundant functions. in the present study, we investigated the potential of protein microarrays to simultaneously scan interactions between surface proteins from two main human streptococcal pathogens, streptoc ... | 2009 | 19417080 |
| bacterial recognition by tlr7 in the lysosomes of conventional dendritic cells. | little is known of how and where bacterial recognition triggers the induction of type i interferon. whether the type of recognition receptor used in these responses is determined by the subcellular location of bacteria is not understood. here we show that phagosomal bacteria such as group b streptococcus, but not cytosolic bacteria, potently induced interferon in conventional dendritic cells by a mechanism that required toll-like receptor 7, the adaptor myd88 and the transcription factor irf1, a ... | 2009 | 19430477 |
| [neonatal group b streptococcus infection: an integrated approach (of clinical pathologists, gynecologists, midwives, pediatricians-neonatologists) of the functional area of cuneo (italy)]. | the frequency of early-onset neonatal sepsis without prophylaxis is 1-5/1.000 live births. since year '70 the most frequent causative microorganism is the group b streptococcus (s. agalactiae, gbs), followed by escherichia coli. the mortality rate is now reduced to 4% due to the improvement of neonatal intensive care. in the usa, the incidence of gbs early-onset neonatal sepsis has been markedly reduced by the application of the guidelines released by the centers for disease control (cdc). this ... | 2008 | 19431950 |
| missed opportunities for preventing group b streptococcus infection. | group b streptococcus (gbs) is the most common cause of early onset (eo) neonatal infection in the uk. national guidelines for its prevention were introduced in 2003. we assessed the opportunities for prevention amongst cases of eo gbs using the electronic neonatal infection surveillance network (neonin). | 2010 | 19439431 |
| diversity of group b streptococcus serotypes causing urinary tract infection in adults. | serotypes of group b streptococcus (gbs) that cause urinary tract infection (uti) are poorly characterized. we conducted a prospective study of gbs uti in adults to define the clinical and microbiological characteristics of these infections, including which serotypes cause disease. patients who had gbs cultured from urine over a 1-year period were grouped according to symptoms, bacteriuria, and urinalysis. demographic data were obtained by reviewing medical records. isolates were serotyped by la ... | 2009 | 19439533 |
| neonatal infections: group b streptococcus. | one in three women carry group b streptococci vaginally, which can infect the amniotic fluid even if the membranes are intact, or can infect the baby during delivery, causing sepsis, pneumonia, or meningitis. very-low-birthweight infants are at much higher risk of infection or mortality, with up to 3% infected, and mortality rates of up to 30% even with immediate antibiotic treatment. late-onset group b streptococcal infection begins after 7-9 days, and usually causes fever or meningitis, but is ... | 2008 | 19450341 |
| molecular and phenotypic characterization of invasive group b streptococcus strains from infants in norway 2006-2007. | multilocus sequence typing of an almost complete collection of invasive group b streptococcus (gbs) strains from infants in norway, conducted in 2006-2007, revealed 27 sequence types (st), of which 23 clustered into five clonal complexes. the case fatality rate of invasive gbs disease in infants was 16/98 (16.3%). type v strains were predominant among strains resistant to erythromycin and clindamycin (11/18; 61.1%). all type v strains from fatal cases (5/16) were st1, resistant to erythromycin a ... | 2009 | 19456824 |
| group b streptococcal disease in infants: a case control study. | to describe and quantify the maternal and neonatal factors associated with group b streptococcus (gbs) disease in infants <90 days of age. | 2009 | 19457879 |
| group b streptococcus infection: epidemiology, serotypes, and antimicrobial susceptibility of selected isolates in the population beyond infancy (excluding females with genital tract- and pregnancy-related isolates) at the university malaya medical centre, kuala lumpur. | group b streptococcus (gbs) infection was studied in 49 patients collected at convenience (convenience sampling), excluding infants and women with genital tract- and pregnancy-related isolates, according to the availability of stocked isolates and easy accessibility to epidemiological data. the data were examined both prospectively and retrospectively from 2003-2005 at a tertiary-level multidisciplinary hospital in kuala lumpur, malaysia. skin and soft-tissue infections in 35 patients (71.4%) we ... | 2009 | 19468178 |
| increasing burden of invasive group b streptococcal disease in nonpregnant adults, 1990-2007. | group b streptococcus (gbs), traditionally considered to be a neonatal pathogen, is an important cause of morbidity and mortality among older adults and among those with underlying medical conditions. we used population-based surveillance to examine trends in adult gbs disease during the period 1990-2007 and to describe the epidemiology of adult gbs disease to guide prevention efforts. | 2009 | 19480572 |
| group b streptococcus vertebral osteomyelitis-discitis in an immunocompetent adolescent. | 2009 | 19483527 | |
| spot diagnosis: an ominous rash in a newborn. | abstract: purpura fulminans (pf) is an ominous cutaneous condition usually associated with meningococcemia. pf in the newborn is rarely reported. we report the case of a female preterm infant with extensive pf due to group b streptococcus (gbs) septicemia. she developed multi-organ system failure despite neonatal intensive care support and succumbed 9 days later. gbs, sensitive to penicillin, was isolated from the blood cultures of the mother and the infant. invasive early gbs infection is commo ... | 2009 | 19490602 |
| inappropriate use of vancomycin for preventing perinatal group b streptococcal (gbs) disease in laboring patients. | the 2002 cdc guidelines for the prevention of perinatal group b streptococcus (gbs) stipulate that vancomycin is reserved for penicillin-allergic women at high risk for beta-lactam anaphylaxis with resistance to clindamycin or erythromycin. our objective was to evaluate practitioner adherence to these guidelines. | 2009 | 19492913 |
| group b streptococcus and early-onset sepsis in the era of maternal prophylaxis. | despite an era of marked success with universal screening, group b streptococcus (gbs) continues to be an important cause of early-onset sepsis, and thus remains a significant public health issue. improved eradication of gbs colonization and disease may involve universal screening in conjunction with rapid diagnostic technologies or other novel approaches. given the complications and potential limitations associated with maternal intrapartum prophylaxis, however, vaccines may be the most effecti ... | 2009 | 19501699 |
| cerebellar injury in term infants: clinical characteristics, magnetic resonance imaging findings, and outcome. | although cerebellar injury in the premature infant is an increasingly recognized form of neonatal brain injury, its structural and functional outcomes remain poorly defined in the term infant. the objective of this cross-sectional study was to characterize the clinical and magnetic resonance imaging features and neurodevelopmental outcome in children, born at term, with cerebellar injury. over a 5-year period, 20 infants were identified with ischemic (n = 3) or hemorrhagic (n = 17) cerebellar in ... | 2009 | 19520266 |
| evaluation of universal antenatal screening for group b streptococcus. | group b streptococcal disease is one of the most common infections in the first week after birth. in 2002, national guidelines recommended universal late antenatal screening of pregnant women for colonization with group b streptococcus to identify candidates for intrapartum chemoprophylaxis. | 2009 | 19535801 |
| csrrs regulates group b streptococcus virulence gene expression in response to environmental ph: a new perspective on vaccine development. | to identify factors involved in the response of group b streptococci (gbs) to environmental ph, we performed a comparative global gene expression analysis of gbs at acidic and neutral phs. we found that the transcription of 317 genes was increased at ph 5.5 relative to that at ph 7.0, while 61 genes were downregulated. the global response to acid stress included the differential expression of genes involved in transport, metabolism, stress response, and virulence. known vaccine candidates, such ... | 2009 | 19542277 |
| transcriptome adaptation of group b streptococcus to growth in human amniotic fluid. | streptococcus agalactiae (group b streptococcus) is a bacterial pathogen that causes severe intrauterine infections leading to fetal morbidity and mortality. the pathogenesis of gbs infection in this environment is poorly understood, in part because we lack a detailed understanding of the adaptation of this pathogen to growth in amniotic fluid. to address this knowledge deficit, we characterized the transcriptome of gbs grown in human amniotic fluid (af) and compared it with the transcriptome in ... | 2009 | 19568429 |
| postoperative pubic symphysis osteomyelitis after laparoscopic two-team sling with anterior and posterior colporrhaphy. | a 53 year-old woman, who previously had a burch colposuspension, developed osteomyelitis of the pubic symphysis about 1 month after undergoing a laparoscopic 2-team sling with anterior and posterior colporrhaphy. the diagnosis was made on the basis of computed tomography-guided aspiration of the pubic symphysis, which was positive for group b streptococcus sp. to our knowledge, this is the first case report of osteomyelitis after a laparoscopic retropubic sling procedure. osteomyelitis is a rare ... | 2009 | 19573835 |
| prenatal group b streptococcus test using real-time polymerase chain reaction. | the aim of this study was to evaluate the percentage of pregnant women with negative group b streptococcus (gbs) screening results by culture at 35 weeks' gestation, who subsequently had positive gbs test results after 39 weeks' gestation. | 2009 | 19574170 |
| diagnostic accuracy of a rapid real-time polymerase chain reaction assay for universal intrapartum group b streptococcus screening. | intrapartum antibiotic prophylaxis is currently given to mothers who test positive for group b streptococcus (gbs) by antenatal culture-based screening, with a risk-based approach for cases with an unknown gbs status. a rapid real-time polymerase chain reaction (pcr) assay for the detection of gbs became available recently, making intrapartum screening possible. we aimed to assess its diagnostic accuracy and to compare it with antenatal screening. | 2009 | 19580414 |
| selection, recombination, and virulence gene diversity among group b streptococcal genotypes. | transmission of group b streptococcus (gbs) from mothers to neonates during childbirth is a leading cause of neonatal sepsis and meningitis. although subtyping tools have identified specific gbs phylogenetic lineages that are important in neonatal disease, little is known about the genetic diversity of these lineages or the roles that recombination and selection play in the generation of emergent genotypes. here, we examined genetic variation, selection, and recombination in seven multilocus seq ... | 2009 | 19581371 |
| biba induces opsonizing antibodies conferring in vivo protection against group b streptococcus. | we recently characterized the function of biba, an immunogenic surface-associated antigen expressed by group b streptococcus (gbs) that is involved in virulence. in this study, we performed a biba gene variability analysis on a panel of 72 clinical isolate strains. the biba gene was present in all the strains analyzed, and 4 allelic variants, correlating with serotype, were identified. moreover, although the biba protein was expressed in all strains tested, only 54% of strains demonstrated surfa ... | 2009 | 19586417 |
| putative novel surface-exposed streptococcus agalactiae protein frequently expressed by the group b streptococcus from zimbabwe. | group b streptococci (gbs) express a variety of surface-exposed and strain-variable proteins which function as phenotypic markers and as antigens which are able to induce protective immunity in experimental settings. among these proteins, the chimeric and immunologically cross-reacting alpha-like proteins are particularly important. another protein, r3, which has been less well studied, occurred at a frequency of 21.5% in gbs from zimbabwe and, notably, occurred in serotype v strains at a freque ... | 2009 | 19587152 |
| intrapartum antibiotics for known maternal group b streptococcal colonization. | maternal colonization with group b streptococcus (gbs) during pregnancy increases the risk of neonatal infection by vertical transmission. administration of intrapartum antibiotic prophylaxis (iap) during labor has been associated with a reduction in early onset gbs disease (eogbsd). however, treating all colonized women during labor exposes a large number of women and infants to possible adverse effects without benefit. | 2009 | 19588432 |
| group b streptococcus suppression of phagocyte functions by protein-mediated engagement of human siglec-5. | group b streptococcus (gbs) is a leading cause of invasive bacterial infections in human newborns. a key gbs virulence factor is its capsular polysaccharide (cps), displaying terminal sialic acid (sia) residues which block deposition and activation of complement on the bacterial surface. we recently demonstrated that gbs sia can bind human cd33-related sia-recognizing immunoglobulin (ig) superfamily lectins (hcd33rsiglecs), a family of inhibitory receptors expressed on the surface of leukocytes. ... | 2009 | 19596804 |
| analysis of phenotype, genotype and serotype distribution in erythromycin-resistant group b streptococci isolated from vaginal flora in southern ireland. | the screening of 2000 women of childbearing age in cork between 2004 and 2006 produced 37 erythromycin-resistant group b streptococcus (gbs) isolates. pcr analysis was performed to determine the basis for erythromycin resistance. the ermtr gene was most frequently expressed (n = 19), followed by the ermb gene (n = 8). four isolates harboured the mefa gene. six isolates yielded no pcr products. some phenotype-genotype correlation was observed. all isolates expressing the mefa gene displayed the m ... | 2010 | 19602300 |
| il-4 deficiency decreases mortality but increases severity of arthritis in experimental group b streptococcus infection. | il-4 is an anti-inflammatory cytokine that inhibits the onset and severity in different experimental arthritis models. group b streptococci (gbs) have been recognized as an ever-growing cause of serious invasive infections in nonpregnant adults. septic arthritis is a clinical manifestation of gbs infection. to investigate the role of il-4 in experimental gbs infection, il-4 deficient or competent mice were inoculated with 1 x 10(7) gbs/mouse. mortality, appearance of arthritis, gbs growth in the ... | 2009 | 19606256 |
| acquisition of factor h by a novel surface protein on group b streptococcus promotes complement degradation. | binding of the host complement regulator, factor h (fh), by some pathogenic microbes constitutes an important virulence mechanism, whereby complement is broken down to help microbes survive in the host. although it has been hypothesized for the past two decades that gbs type iii binds fh via sialic acid present on its capsule, neither the binding of fh to gbs has been demonstrated nor the mechanism of interaction identified. we observed that fh bound to both wild-type and capsule or sialic acid- ... | 2009 | 19608625 |
| prevalence of asymptomatic bacteriuria among pregnant women in shiraz, iran. | to determine the frequency of asymptomatic bacteriuria in pregnant women referred to a university college hospital in shiraz, iran for perinatal care, and also to determine the relation between asymptomatic bacteriuria and pyuria. | 2009 | 19618007 |
| group b streptococcus induces tyrosine phosphorylation of annexin v and glutathione s-transferase in human umbilical vein endothelial cells. | group b streptococcus (gbs), a human pathogen that causes infection and invasive diseases in newborns, pregnant women and immunocompromised adults, has been shown to invade human umbilical vein endothelial cells (huvecs). the objective of this study was to investigate the molecular mechanisms underlying gbs-huvec interaction, focusing specifically on the responsiveness of host protein tyrosine kinase (ptk). we found that gbs serotypes iii and v induced actin reorganization and formation of stres ... | 2009 | 19639233 |
| comparative evaluation of the accuprobe group b streptococcus culture test, the bd geneohm strep b assay, and culture for detection of group b streptococci in pregnant women. | we compared a rigorous culture method with the gen-probe accuprobe group b streptococcus culture test (apgb) and the bd geneohm strepb assay (gosb) for the detection of group b streptococci (gbs) from an 18- to 24-h lim broth. culture (95.3%) and gosb (95.3%) were more sensitive than apgb (86.5%) for the detection of gbs. | 2009 | 19641065 |
| genetic and biochemical modulation of sialic acid o-acetylation on group b streptococcus: phenotypic and functional impact. | group b streptococcus (gbs) is an important human pathogen and a model system for studying the roles of bacterial glycosylation in host-microbe interactions. sialic acid (sia), expressed prominently in the gbs capsular polysaccharide (cps), mimics mammalian cell surface sia and can interact with host sia-binding proteins to subvert immune clearance mechanisms. our earlier work has shown that gbs partially o-acetylates cps sia residues and employs an intracellular o-acetylation/de-o-acetylation c ... | 2009 | 19643844 |
| prevention of group b streptococcus early-onset disease: a toolkit by the california perinatal quality care collaborative. | the california perinatal quality care collaborative (cpqcc) was organized in 1996 in an effort to improve perinatal outcomes in california. cpqcc has a robust infrastructure of quality improvement resources and expertise and uses a database of demographic and outcome data from neonatal intensive care units in california. in 2004, cpqcc developed a toolkit to provide an evidence-based framework and supporting documents for hospitals to use in systematically addressing persistent early-onset disea ... | 2010 | 19657350 |
| association between colonization with group b streptococcus and preterm delivery: a systematic review. | up to 36% of pregnant women are colonized with group b streptococcus (gbs). preterm delivery in colonized mothers is a risk factor for early onset neonatal gbs disease, but whether maternal gbs genital colonization is related to preterm delivery is unclear. the objective of this review was to determine the relationship between maternal colonization with gbs and preterm delivery. pubmed searches and reference lists of all selected publications were used to find studies reporting on the relationsh ... | 2009 | 19657755 |
| extracranial infected carotid artery aneurysm. | infected aneurysms of the extracranial carotid arteries are rare. this is a case report of a 63-year-old female who developed an infected internal carotid artery aneurysm due to group b streptococcus ten days after a dental procedure. she was successfully treated with excision of the aneurysm and common to internal carotid artery bypass with greater saphenous vein. | 2009 | 19703747 |
| clinical aspects of invasive infections with streptococcus dysgalactiae ssp. equisimilis in japan: differences with respect to streptococcus pyogenes and streptococcus agalactiae infections. | streptococcus dysgalactiae ssp. equisimilis (sdse) is increasingly being identified as a pathogen responsible for invasive and non-invasive infections. we compared the clinical features of invasive sdse infections with those of invasive infections caused by streptococcus pyogenes (group a streptococcus (gas)) and streptococcus agalactiae (group b streptococcus (gbs)). active surveillance for invasive sdse, gas and gbs was maintained over 1 year at 142 medical institutions throughout japan. clini ... | 2010 | 19732082 |
| diversity in cytokine response to bacteria associated with preterm birth by fetal membranes. | this study compared cytokine and prostaglandin (pg) responses by fetal membranes stimulated with 4 different bacterial species associated with preterm birth (ptb). | 2009 | 19733282 |
| perinatal care for south asian immigrant women and women born in canada: telephone survey of users. | previous research findings suggest that pregnant immigrant women receive less adequate perinatal care than pregnant non-immigrant women. this study was designed to assess the use of perinatal care services by newly immigrated south asian women and canadian-born women, and to determine any perceived barriers to receiving care. | 2009 | 19772702 |
| identification of an unusual pattern of global gene expression in group b streptococcus grown in human blood. | because passage of the bacterium to blood is a crucial step in the pathogenesis of many group b streptococcus (gbs) invasive infections, we recently conducted a whole-genome transcriptome analysis during gbs incubation ex vivo with human blood. in the current work, we sought to analyze in detail the difference in gbs gene expression that occurred in one blood sample (donor a) relative to other blood samples. we incubated gbs strain nem316 with fresh heparinized human blood obtained from healthy ... | 2009 | 19774088 |
| rapid testing for group b streptococcus during labour: a test accuracy study with evaluation of acceptability and cost-effectiveness. | to determine the accuracy, acceptability and cost-effectiveness of polymerase chain reaction (pcr) and optical immunoassay (oia) rapid tests for maternal group b streptococcal (gbs) colonisation at labour. | 2009 | 19778493 |
| epidemiology of group b streptococcus in korean pregnant women. | between january 2006 and may 2008, 2624 pregnant s. korean women between 35-37 weeks gestation were screened for group b streptococcus (gbs). resistance to antimicrobials was tested by disk diffusion and serotype determined using co-agglutination assays and microarray methods. overall, 8% of pregnant women were colonized. serotype iii was the predominant serotype (43.8%), followed by serotypes v (20.3%), ia (12.1%), and ib (9.5%). gbs was frequently resistant to clindamycin (54.0%) and erythromy ... | 2010 | 19781117 |
| fever without localizing signs in children: a review in the post-hib and postpneumococcal era. | fever without localizing signs in young infants and children has been a common problem for pediatric practitioners for decades. prior to the introduction of vaccines against common childhood invasive pathogens, including haemophilus influenzae type b (hib) and streptococcus pneumoniae, extensive diagnostic workup of febrile infants and children was warranted to avoid missing serious bacterial infections. at that time, occult bacteremia occurred at a rate of 5.7%. evaluation of febrile children w ... | 2009 | 19794375 |
| the effect of digital cervical examination on group b streptococcal culture. | we sought to evaluate whether group b streptococcus (gbs) detection is altered by the digital cervical examination. | 2010 | 19804878 |
| toll-like receptor 2 dependent immunogenicity of glycoconjugate vaccines containing chemically derived zwitterionic polysaccharides. | group b streptococcus (gbs) causes serious infection in neonates and is an important target of vaccine development. zwitterionic polysaccharides (zps), obtained through chemical introduction of positive charges into anionic polysaccharides (ps) from gbs, have the ability to activate human and mouse antigen presenting cells (apcs) through toll-like receptor 2 (tlr2). to generate a polysaccharide vaccine with antigen (ag) and adjuvant properties in one molecule, we have conjugated zps with a carri ... | 2009 | 19805031 |
| practical disk diffusion test for detecting group b streptococcus with reduced penicillin susceptibility. | although group b streptococcus (gbs) has been considered to be uniformly susceptible to beta-lactams, the presence of gbs with reduced penicillin susceptibility (prgbs) was recently confirmed genetically. we developed a feasible and reliable method for screening prgbs in clinical microbiology laboratories using a combination of ceftibuten, oxacillin, and ceftizoxime disks. | 2009 | 19812274 |
| evaluation of three commercial broth media for pigment detection and identification of a group b streptococcus (streptococcus agalactiae). | detection of group b streptococcus (gbs) strains at various bacterial concentrations was evaluated using three pigment-producing broth media. at 10(3) cfu/ml, strepb carrot broth (sbcb), granada instant liquid biphasic (iglb), and northeast laboratory gbs screening medium (nel-gbs) showed 100% detection, but at the lower bacterial counts, sbcb and iglb were more sensitive than nel-gbs after 24 h. | 2009 | 19812277 |
| painless blood testing to prevent neonatal sepsis. | the current us guidelines advise that all women colonized with group b streptococcus (gbs) at 35-37 weeks, as well as those laboring before this time and all women with gbs urinary tract infections, should be offered intrapartum antibiotic prophylaxis, usually in the form of high-dose intravenous penicillin or ampicillin, unless delivered by planned cesarean section before the onset of labor in a woman with intact membranes. in term and preterm babies who are born to treated women, in addition t ... | 2009 | 19813501 |
| very late-onset group b streptococcus meningitis, sepsis, and systemic shigellosis due to interleukin-1 receptor-associated kinase-4 deficiency. | we describe a child with very late-onset group b streptococcus sepsis and meningitis, systemic shigellosis, and chronic osteomyelitis. peripheral blood cells obtained from the patient and her brother did not respond to stimulation with either interleukin-1beta or lipopolysaccharide. sequencing of the interleukin-1 receptor-associated kinase-4 gene revealed 2 novel mutations. | 2009 | 19814626 |
| asymptomatic bacteriuria in pregestational diabetic pregnancies and the role of group b streptococcus. | we sought to determine if gravidas with pregestational diabetes mellitus (dm) are at increased risk for asymptomatic bacteriuria (asb) compared with nondiabetic gravidas. this is a retrospective case-control study of 150 pregnant patients with pregestational dm and 294 nondiabetic controls. rates of asb and any colony count of group b streptococcus (gbs) bacteriuria were reviewed. the incidence of asb among pregestational diabetics was higher compared with nondiabetic gravidas (18% versus 8.2%, ... | 2010 | 19834868 |
| frequency of detection of methicillin-resistant staphylococcus aureus from rectovaginal swabs in pregnant women. | clinical samples from 250 pregnant women undergoing screening for rectovaginal group b streptococcus colonization were evaluated concurrently for the presence of methicillin-resistant staphylococcus aureus (mrsa). overall, s aureus was detected in 21.6% of the women; 53.7% of the isolates were mrsa. despite a lack of risk factors for mrsa colonization, rectovaginal mrsa was detected in 10.4% of pregnant women in this study. | 2010 | 19836855 |
| [group b streptococcus maternal and neonatal colonization in preterm rupture of membranes and preterm labor]. | to identify the prevalence and risk factors of maternal colonization by group b streptococcus (gbs) in pregnant women with premature labor (pl) and/or premature membrane rupture (pmr). | 2009 | 19838588 |
| choriodecidual inflammation: a harbinger of the preterm labor syndrome. | causal, cellular, and inflammatory links between choriodecidual infection with group b streptococcus (gbs) and preterm labor were assessed in a nonhuman primate model. rhesus monkeys received varying doses of a clinical isolate of gbs, type iii or saline, via an indwelling catheter placed between the chorion/decidua and myometrium in the lower pole of the uterus. choriodecidual inoculation of gbs was followed by a graded response in amniotic fluid (af) leukocytes, proinflammatory cytokines, pros ... | 2010 | 19843879 |
| chlorhexidine maternal-vaginal and neonate body wipes in sepsis and vertical transmission of pathogenic bacteria in south africa: a randomised, controlled trial. | about 500,000 sepsis-related deaths per year arise in the first 3 days of life. on the basis of results from non-randomised studies, use of vaginal chlorhexidine wipes during labour has been proposed as an intervention for the prevention of early-onset neonatal sepsis in developing countries. we therefore assessed the efficacy of chlorhexidine in early-onset neonatal sepsis and vertical transmission of group b streptococcus. | 2009 | 19846212 |
| group b streptococcus meningitis in a child with cochlear implant. | 2009 | 19861082 | |
| serotype distribution and antibiotic susceptibility of group b streptococci in pregnant women. | group b streptococcus (gbs) is a leading cause of neonatal sepsis and is usually acquired via the woman's birth canal. gbs serotypes isolated from 200 pregnant women were determined. serotypes v (19%) and vi (17%) were the most frequent followed by serotypes iii (12%), ia (11.5%) and iv (10%); 17% of the strains were non-typable. all isolates were susceptible to penicillin, 96% to erythromycin and 97.5% to clindamycin. the emergence of new gbs serotypes has important implications for vaccine pre ... | 2010 | 19889253 |
| [evaluation of 6 years of group b streptococcus (gbs) screening in near-term pregnant women]. | streptococcus agalactiae (gbs) is a significant cause of morbidity and mortality among newborns. colonization frequently occurs in pregnant women, nearly all international recommendations suggest that all pregnant women must be screened for vaginal colonization at 34 to 37 weeks of gestation. the microbiological diagnostic modalities used to combat gbs had to be accurate and in short time frame. we reported a 6 years experience of gbs screening, comparing results of culture swab of prenatal vagi ... | 2010 | 19892482 |
| an outbreak of hemodialysis catheter-related bacteremia with sepsis caused by streptococcus agalactiae in a hemodialysis unit. | rates of invasive group b streptococcus (gbs; streptococcus agalactiae) disease in adults are on the rise. invasive gbs disease can be community- or healthcare-associated. we report an outbreak of gbs catheter-related bacteremia in a hemodialysis (hd) unit. | 2010 | 19896882 |
| commonly used molecular epidemiology markers of streptococcus agalactiae do not appear to predict virulence. | several virulent clones of group b streptococcus (gbs) are known to be associated with certain serotypes and molecular epidemiological markers. it is unclear, however, whether the clinical significance of gbs can be predicted based solely on such molecular markers. the aim of this study was to test the hypothesis that gbs virulence can be predicted by using the molecular epidemiology markers. | 2009 | 19900108 |
| intranasal immunization with gbs surface protein sip and scpb induces specific mucosal and systemic immune responses in mice. | sip and scpb are highly conserved among strains of group b streptococcus (gbs). thus, the two proteins are attractive antigens for inclusion in a vaccine against gbs. in this study, we constructed and expressed the two proteins, and investigated their specific mucosal immune responses against gbs induced by intranasal immunization with cholera toxin (ct) and cpg-oligodeoxynucleotides (cpg-odns). intranasal immunization with different doses of recombinant sip and scpb all elicited specific antibo ... | 2010 | 19912341 |
| group b streptococcus early-onset disease in emilia-romagna: review after introduction of a screening-based approach. | group b streptococcus (gbs) is a leading cause of neonatal bacterial infections. early-onset infections have decreased in recent years but, despite considerable efforts poured into prevention, cases continue to occur. | 2010 | 19915512 |
| group b streptococcus colonization during pregnancy and maternal-fetal transmission in zimbabwe. | to explore risk factors for group b streptococcus (gbs) colonization during pregnancy and at delivery, estimate the predictive value of early gbs colonization for colonization at delivery and in the newborn, and explore the relationship to adverse perinatal factors. | 2010 | 19916889 |
| the tpl2 mutation sluggish impairs type i ifn production and increases susceptibility to group b streptococcal disease. | sluggish was identified in a population of third generation mice descended from n-ethyl-n-nitrosourea-mutagenized sires. macrophages from homozygotes exhibited impaired tnf-alpha production in response to all tlr ligands tested and displayed impaired type i ifn production in response to tlr7 and tlr9 stimulations. the phenotype was confined to a critical region on mouse chromosome 18 and then ascribed to a t to a transversion in the acceptor splice site of intron 4 at position 13346 of the map3k ... | 2009 | 19923465 |
| antibiotic therapy in preterm premature rupture of the membranes. | to review the evidence and provide recommendations on the use of antibiotics in preterm premature rupture of the membranes (pprom). | 2009 | 19941711 |
| maternal and neonatal colonisation of group b streptococcus at muhimbili national hospital in dar es salaam, tanzania: prevalence, risk factors and antimicrobial resistance. | group b streptococcus (gbs), which asymptomatically colonises the vaginal and rectal areas of women, is the leading cause of septicemia, meningitis and pneumonia in neonates. in tanzania no studies have been done on gbs colonisation of pregnant women and neonates. this study was conducted in dar es salaam, tanzania to determine the prevalence of gbs colonisation among pregnant women, the neonatal colonisation rate and the antimicrobial susceptibility, thus providing essential information to form ... | 2009 | 19948075 |
| early-onset group b streptococcus neonatal disease: a target for prevention? | 2009 | 19966343 | |
| change in prevalence of group b streptococcus maternal colonisation in hong kong. | to re-examine the prevalence of group b streptococcus colonisation in our antenatal population, and identify demographic factors associated with carriage. | 2009 | 19966344 |
| structure of laminin-binding adhesin (lmb) from streptococcus agalactiae. | adhesion/invasion of pathogenic bacteria is a critical step in infection and is mediated by surface-exposed proteins termed adhesins. the crystal structure of recombinant lmb, a laminin-binding adhesin from streptococcus agalactiae, has been determined at 2.5 a resolution. based on sequence and structural homology, lmb was placed into the cluster 9 family of the abc (atp-binding cassette) transport system. the structural organization of lmb closely resembles that of abc-type solute-binding prote ... | 2009 | 19966412 |
| late and ultra late onset streptococcus b meningitis: clinical and bacteriological data over 6 years in france. | group b streptococcus (gbs) is one of the leading causes of sepsis and meningitis in newborn. the objective of this study was to describe the characteristics of gbs meningitis in children aged between 7 and 89 days (late onset disease - lod group) and to compare them with children aged more than 3 months (ultra late onset disease - ulod group). | 2010 | 20002014 |
| cytokine production by peripheral blood mononuclear cells of women with a history of preterm birth. | preterm birth is associated with elevated production of pro-inflammatory cytokines such as tnfalpha at the maternal-fetal interface. previous studies have suggested that women with a history of preterm birth produce aberrantly strong inflammatory responses to bacterial lipopolysaccharide (lps). however many intrauterine infections in women are associated with pathogens including ureaplasma urealyticum, mycoplasma hominis and streptococcus agalactiae (group b streptococcus) that contain pro-infla ... | 2010 | 20005575 |
| timing of group b streptococcus screening in pregnancy: a systematic review. | group b streptococcus (gbs) is an important cause of neonatal sepsis. guidelines advise to collect cultures at 35-37 weeks' gestation and to administer intrapartum antibiotic prophylaxis in case of gbs-positive cultures, as well as in all preterm deliveries. improved effectiveness of antenatal cultures might help to further decrease gbs early-onset disease. | 2010 | 20016190 |
| outbreak of late-onset group b streptococcus in a neonatal intensive care unit. | in september 2007, the tennessee department of health was notified of a cluster of late-onset group b streptococcal (gbs) infections in a neonatal intensive care unit (nicu). outbreaks of late-onset gbs are rare. | 2010 | 20022407 |
| the effect of a chlorhexidine-based surgical lubricant during pelvic examination on the detection of group b streptococcus. | the objective of the study was to estimate whether surgical lubricant used during pelvic examination alters the detection of group b streptococcus (gbs). | 2010 | 20022579 |
| evidence for rare capsular switching in streptococcus agalactiae. | the polysaccharide capsule is a major antigenic factor in streptococcus agalactiae (lancefield group b streptococcus [gbs]). previous observations suggest that exchange of capsular loci is likely to occur rather frequently in gbs, even though gbs is not known to be naturally transformable. we sought to identify and characterize putative capsular switching events, by means of a combination of phenotypic and genotypic methods, including pulsed-field gel electrophoretic profiling, multilocus sequen ... | 2010 | 20023016 |
| prenatal group b streptococcus test using real-time polymerase chain reaction. | 2009 | 20045777 | |
| clindamycin-resistant group b streptococcus and failure of intrapartum prophylaxis to prevent early-onset disease. | guidelines recommend intrapartum antibiotic prophylaxis (iap) for parturient women who have a screen positive for group b streptococcus (gbs). clindamycin should be used for iap only if the maternal gbs isolate is susceptible. we report a case of clindamycin-resistant gbs disease in a newborn infant whose mother received clindamycin iap, and we review clindamycin susceptibility testing. | 2010 | 20056242 |
| neonatal retroauricular cellulitis as an indicator of group b streptococcal bacteremia: a case report. | the relation between cellulitis and group b streptococcus infection in newborns and small infants was first reported during the early 1980s and named cellulitis-adenitis syndrome. we report a case of a neonate with cellulitis-adenitis syndrome in an unusual location (retroauricular). | 2009 | 20062760 |
| pretreatment with pancaspase inhibitor (z-vad-fmk) delays but does not prevent intraperitoneal heat-killed group b streptococcus-induced preterm delivery in a pregnant mouse model. | caspases and apoptosis are thought to play a role in infection-associated preterm-delivery. we have shown that in vitro treatment with pancaspase inhibitor z-vad-fmk protects trophoblasts from microbial antigen-induced apoptosis. objective. to examine whether in vivo administration of z-vad-fmk would prevent infection-induced preterm-delivery. methods. we injected 14.5 day-pregnant-mice with heat-killed group b streptococcus (hk-gbs). apoptosis within placentas and membranes was assessed by tune ... | 2009 | 20069051 |
| withdrawn. intrapartum antibiotics for group b streptococcal colonisation. | group b streptococcal infection is common in pregnant women without causing harm. however it is also a significant cause of neonatal morbidity and mortality. | 2010 | 20091501 |
| compliance with group b streptococcus testing prior to labor and delivery. | we tested whether group b streptococcus (gbs) screening is performed as recommended by the centers for disease control and prevention (cdc) and evaluated the need for a rapid gbs test for women with full-term pregnancies. a retrospective cohort analysis at a single, large academic institution was performed. women who delivered full-term (>37 weeks) infants and had documented prenatal care were included. the primary outcome was documented screening. one hundred sixty-five full-term pregnancies we ... | 2010 | 20094974 |
| association of group b streptococcus colonization and bovine exposure: a prospective cross-sectional cohort study. | while group b streptococcus (gbs) human colonization and infection has long been suspected as originating from cows, several investigators have suggested that ongoing interspecies gbs transmission is unlikely due to genotyping data demonstrating that human and bovine-derived gbs strains represent mostly distinct populations. the possibility of ongoing transmission between humans and their livestock has not been systematically examined. | 2010 | 20098699 |
| prevalence of non-penicillin-susceptible group b streptococcus in philadelphia and specificity of penicillin resistance screening methods. | a total of 1,991 group b streptococcus (gbs) isolates, collected in 2008 and 2009, were tested for non-penicillin susceptibility by broth microdilution, disk testing, and oxacillin screening agar. no gbs isolates were non-penicillin susceptible. oxacillin and ceftizoxime disk testing results showed that proposed screening criteria are nonspecific. the oxacillin screening agar was specific but of unknown sensitivity. | 2010 | 20107093 |
| lack of b7-1 and b7-2 costimulatory molecules modulates the severity of group b streptococcus-induced arthritis. | group b streptococci have long been known as a leading cause of life-threatening infection in neonates, young infants and pregnant women, and recently have been recognized as an ever-growing cause of serious invasive infections in nonpregnant adults. b7-1 and b7-2 are two molecules with immunoregulatory functions implicated in the differentiation of t cells. the present study examined the role of b7-1 and b7-2 during group b streptococci-induced sepsis and arthritis. b7-1- or b7-2-deficient mice ... | 2010 | 20114085 |
| reading vintage news of 1909: change in prevalence of group b streptococcus. | 2010 | 20124582 | |
| group b streptococcus (gbs) urinary tract infection involves binding of gbs to bladder uroepithelium and potent but gbs-specific induction of interleukin 1alpha. | group b streptococcus (gbs) causes urinary tract infections, but the pathogenic mechanisms underlying gbs urinary tract infections are unknown. we investigated whether uropathogenic gbs can bind to bladder uroepithelium to initiate urinary tract infection. uropathogenic gbs isolated from a patient with acute cystitis bound to human t24 bladder uroepithelial cells in close association with f-actin in statistically significantly higher numbers compared with nonuropathogenic gbs. in vivo modeling u ... | 2010 | 20132033 |
| preterm labor. | preventing preterm delivery remains one of the great challenges in modern medicine. preterm birth rates continue to increase and accounted for 12.7 percent of all u.s. births in 2005. the etiology of preterm delivery is unclear, but is likely to be complex and influenced by genetics and environmental factors. women with previous preterm birth are at increased risk of subsequent preterm delivery and may be candidates for treatment with antenatal progesterone. fetal fibronectin testing and endovag ... | 2010 | 20148502 |
| specific involvement of pilus type 2a in biofilm formation in group b streptococcus. | streptococcus agalactiae is the primary colonizer of the anogenital mucosa of up to 30% of healthy women and can infect newborns during delivery and cause severe sepsis and meningitis. persistent colonization usually involves the formation of biofilm and increasing evidences indicate that in pathogenic streptococci biofilm formation is mediated by pili. recently, we have characterized pili distribution and conservation in 289 gbs clinical isolates and we have shown that gbs has three pilus types ... | 2010 | 20169161 |
| [childhood bacterial meningitis trends in japan from 2007 to 2008]. | we surveyed pediatrics bacterial meningitis epidemiology from january 2007 to december 2008 in japan, with the following results: cases numbered 287-160 male and 127 female-equivalent to 1.54-1.62 of 1,000 pediatric hospitalization per year. children under 1-year-old accounted for the highest number of cases, which decreased with increasing age. haemophilus influenzae was the most common cause of infection, followed by streptococcus pneumoniae, group b streptococcus (gbs), and escherichia coli. ... | 2010 | 20170012 |