Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [class v restorations: new therapeutic approaches]. | 2010 | 2945535 | |
| a comparison of five different methods for the detection of tnp specific mouse ige: elisa, elisa on cells, rosetting, granule enzyme release assay and passive cutaneous anaphylaxis. | using the same anti-tnp hybridoma supernatant pool as ige antibody source (2 micrograms/ml), several methods were compared for their sensitivity in ige detection and convenience for screening purposes. using rat basophilic leukemia (rbl) cells as specific receptor cells, one out of two rosetting methods with tnp-sheep red blood cells allowed the detection of 0.5 ng ige/ml (50 pg/assay) while the other was much less sensitive (60 ng/ml). more convenient for screening was an elisa method performed ... | 1986 | 2945867 |
| utilization of formal social support services by non-institutionalized ill elderly. | 2009 | 2948279 | |
| [specific trophoblastic beta-glycoprotein in obstetric practice]. | 2010 | 2948407 | |
| [relationship of hand temperature and blood beta-endorphin-like immunoreactive substance with electroacupuncture induction of ovulation]. | 2010 | 2949892 | |
| extrafacial rosacea is rare but does exist. | 2010 | 2950144 | |
| [involvement of the lumbosacral trunk during delivery]. | 2010 | 2950487 | |
| [creatinine clearance in the elderly. comparison of results obtained by different methods of evaluation]. | 2010 | 2950506 | |
| purification and immunological studies of selenoprotein a of the clostridial glycine reductase complex. | one of the essential catalytic components of the clostridial glycine reductase complex is a selenium-containing protein, selenoprotein a. an improved method for the purification of selenoprotein a has been developed that yields milligram quantities of the protein in a few relatively simple steps. ferredoxin and rubredoxin can be recovered in pure form as by-products of the procedure. the high resolving capabilities of an anion exchange high pressure liquid chromatography step were exploited in t ... | 1987 | 2951374 |
| [listeria rhomboencephalitis without meningeal involvement]. | 1987 | 2953019 | |
| the classic. concept of disability. by earl d. mcbride. 1963. | 2010 | 2955987 | |
| [teicoplanin and gram-positive coccus infections. results of a multicenter study on 66 cases]. | sixty-six cases of gram positive infections were treated with teicoplanin in an open multicenter study, comprising 7 centers in eastern france. there were 38 male patients and 28 females. teicoplanin was given at a dose of 400 mg daily for a mean duration of 18.4 days. the most common infections were due to staphylococcus aureus, found in 43 out of 56 documented cases. 69 (89.9%) of the 78 gram + strains isolated had an mic for teicoplanin of less than or equal to 2 mg/l. there were 44 serious i ... | 1987 | 2956564 |
| preload dependence of doppler-derived indexes of left ventricular diastolic function in humans. | to determine the effect of filling pressure on the pattern of left ventricular filling in humans, the mitral flow velocity profile was measured by pulsed wave doppler echocardiography during right and left heart catheterization in 11 patients before and during nitroglycerin infusion. nitroglycerin reduced mean arterial pressure from 90 +/- 9 to 80 +/- 11 mm hg (p less than 0.001) and mean pulmonary capillary wedge pressure from 9 +/- 4 to 4 +/- 2 mm hg (p less than 0.001). cardiac output fell fr ... | 2003 | 2958532 |
| [immunological structure of the populations of the upper and middle volga river regions in relation to the causative agent of yersiniosis and its determining factors]. | the study of the immunological structure of the population in respect of intestinal yersiniosis at territories with different hydrothermal conditions has revealed the presence of a greater immune stratum (23.9% with the average agglutination titer being 1.8 +/- 0.09 log d) in humid areas, such as the region of the upper volga, in comparison with dry areas, such as the region of the middle volga, where the level of the immune stratum has proved to be twice as low (10.6% with the average agglutina ... | 1987 | 2961172 |
| chronic renal disease and hyperparathyroidism: dental manifestations and management. | 2010 | 2963695 | |
| the pattern of atrial natriuretic peptide release during ventricular tachycardia in man. | 1. plasma levels of atrial natriuretic peptide (anp) are high in many patients with tachycardia, but patterns of release with onset and termination of tachycardia and relationships to haemodynamic recordings are not clear. blood for anp measurements was therefore drawn from the coronary sinus, femoral artery and femoral vein, and simultaneous haemodynamic recordings were made in five patients before, during and after induction of stable ventricular tachycardia for 30 min. 2. tachycardia induced ... | 1987 | 2963719 |
| chlorambucil allergy--a series of three cases. | three cases of chlorambucil-related skin eruption in patients with low-grade non-hodgkin's lymphoma are described. cases were confirmed by exclusion of other drugs, rechallenge, skin testing and histology. one patient died due to florid erythema multiforme. only two other adequately documented cases are described. | 2010 | 2965869 |
| activation of a cytosolic serine protein kinase by epidermal growth factor. | exposure of a-431 cells to epidermal growth factor (egf) results in a rapid enhancement (approximately 10-fold) of cytosolic serine protein kinase activity. the increase in serine kinase activity may be detected using a number of peptide and protein substrates. enhancement of kinase activity occurs within 1 min of exposure of the cells to egf and reaches a maximum in 5 min. similar results were obtained with a variety of cell lines. we have partially purified the egf-activated kinase from a-431 ... | 2010 | 2974035 |
| [sudden death in cerebral epidermoid tumor (forensic autopsy in 2 cases)]. | 2007 | 2975035 | |
| [application of ptca steerable guide wire for abdominal and peripheral interventional angiography]. | 2010 | 2975374 | |
| [testicular metastasis of prostatic carcinoma: presentation of a case and a review of the literature]. | 2010 | 2976183 | |
| effect of atrial peptide on collecting duct function. | 1. the effects of synthetic rat atrial natriuretic peptides (anp) on diffusional 22na+, 36cl- and tritiated water (tho) permeability of in vitro microperfused rat papillary collecting ducts and the effect in vivo of anp on stop-flow sodium concentrations in the terminal segment of rabbit nephrons were studied. 2. the addition of 4 x 10(-8) or 4 x 10(-7) mol/l anp to the medium or perfusion solution did not alter diffusional 22na+ or 36cl- permeability of microperfused rat papillary collecting du ... | 1988 | 2976327 |
| ex vivo platelet studies following oral nisoldipine in normotensive insulin-dependent diabetics and non-diabetic controls. | the effect of 24 hours and 7 days treatment with nisoldipine (10 mg, twice daily) on platelet function was studied in 12 normotensive volunteers of whom six were insulin-dependent diabetics without clinical evidence of vascular complications. platelet aggregation was assessed by platelet rich plasma (prp) and whole blood (wb) techniques. in addition, the effect of nisoldipine on platelet hyperaggregability following exercise was assessed. after taking nisoldipine for 24 hours, in vitro platelet ... | 2010 | 2976336 |
| [macrolides: a critical re-evaluation]. | 2010 | 2976351 | |
| responses to passive movement of receptors in joint, skin and muscle of the human hand. | 1. microneurographic techniques were employed to record unitary activity from afferents associated with digital joints of six conscious human subjects. of 120 single afferents sampled from the median and ulnar nerves at the wrist, eighteen (15%) were classified as joint afferents; the majority of the sample (72.5%) were of cutaneous origin, and 12.5% were from muscle spindles and tendon organs. 2. of the eighteen joint afferents six were tonically active in the rest position of the hand. all exc ... | 1988 | 2976823 |
| principles of the diagnostic system 'orfèvre' for computerized analysis in radiology. | 2010 | 2980470 | |
| corticotropin-releasing factor desensitization of adrenocorticotropic hormone release is augmented by arginine vasopressin. | the desensitization of corticotropin-releasing factor (crf)-stimulated acth release from and intracellular cyclic amp accumulation in anterior pituitary cells was investigated in primary cultures of rat pituitary cells and in a mouse tumor cell line (att 20/d16-16). crf potently stimulated acth secretion and cyclic amp accumulation in both preparations. when primary cultures were preincubated with 100 nm crf, 50% desensitization of acth release occurred within 4 hr while similar desensitization ... | 1985 | 2981299 |
| viremia is present in incubation period in nonimmunocompromised children with varicella. | 1985 | 2981309 | |
| electron microscopy after direct ultracentrifugation. | a direct ultracentrifugation technique was used in the preparation of skin lesion specimens for examination by electron microscopy. the concentration factor of centrifuged specimens was estimated to be in excess of 1,000-fold compared to conventional adsorption techniques. this resulted in an increase of over 300% in the detection rate of herpesviruses and poxviruses from skin lesion specimens. | 2010 | 2987776 |
| specific binding of radioiodinated granulocyte-macrophage colony-stimulating factor to hemopoietic cells. | the hemopoietic growth factor granulocyte-macrophage colony-stimulating factor, gm-csf, specifically controls the production of granulocytes and macrophages. this report describes the binding of biologically-active 125i-labeled murine gm-csf to a range of hemopoietic cells. specific binding was restricted to murine cells and neither rat nor human bone marrow cells appeared to have surface receptors for 125i-labeled gm-csf. 125i-labeled gm-csf only appeared to bind specifically to cells in the my ... | 1985 | 2990915 |
| macrophage colony-stimulating factor (m-csf) enhances the capacity of murine macrophages to secrete oxygen reduction products. | the capacity of macrophage colony-stimulating factor (m-csf) to enhance respiratory burst activity in peritoneal macrophages was measured. macrophages incubated for 48 hr or more with concentrated l cell-conditioned medium as a source of m-csf released two to three times as much o2- in response to pma as did unexposed macrophages. stimulation was noted at concentrations of colony-stimulating activity from 0.1 to 2000 u/ml and was maximal at 10 to 100 u/ml. purified, endotoxin-free csf enhanced s ... | 2010 | 2991376 |
| diverse involvements of ni protein in superoxide anion production in polymorphonuclear leukocytes depending on the type of membrane stimulants. | effects of islet-activating protein (iap) were examined to assess the involvement of the guanine nucleotide-binding regulatory protein responsible for inhibition of adenylate cyclase system (ni protein) in the superoxide anion (o-2) production in polymorphonuclear leukocytes (pmnl) stimulated with various agents. n-formyl-methionyl-leucyl-phenylalanine (fmlp)-stimulated o-2 production was inhibited by the pretreatment with iap. o-2 production induced by each of phorbol myristate acetate, concana ... | 1985 | 2992509 |
| a serum-free growth of a human hepatoma cell line as a tool for hepatocarcinogenesis and virus gene expression. | the plc/prf/5 human hepatoma cells were grown in a serum-free, hormone-free, chemically defined medium; we recently characterized cell growth and hepatitis b surface antigen (hbsag) production by these cells under these culture conditions, in the absence of interfering substances. because of the biochemical and the antigenic properties of plc/prf/5 cell line showing a marked similarity to in vivo hepatocellular carcinoma, this cell line provides an in vitro system for the study both of hepatitis ... | 1985 | 2995177 |
| a single genetic locus encoded by yersinia pseudotuberculosis permits invasion of cultured animal cells by escherichia coli k-12. | for many species of pathogenic bacteria, invasion and survival within animal cells is central to establishing a successful host-parasite relationship. localization within host cells protects the microorganism from host defences, or permits it to cross epithelial barriers and subsequently become systemically distributed. the precise mechanisms that permit entry of bacteria into host tissues are unclear, therefore we have been studying the invasion of epithelial cells by yersinia pseudotuberculosi ... | 1985 | 2995819 |
| porphyria cutanea tarda and hepatocellular carcinoma. frequency of occurrence and related factors. | in order to assess the incidence of hepatocellular carcinoma (hcc) in porphyria cutanea tarda (pct), 83 patients (77 males, 6 females, mean age 57.4 years) were studied. thirteen patients (15.7%) had hcc, all of whom were male and cirrhotics with a mean age of 58.5 years. hcc patients showed a statistically significant (p less than 0.0005) longer evolution time (23 years since onset of the cutaneous disease) than patients without hcc (9.4 years), while the age of onset was similar in both groups ... | 1985 | 2997323 |
| rflp for the human apolipoprotein b gene: ii;ecori. | 1985 | 2997725 | |
| diaziquone as a potential agent for photoirradiation therapy: formation of the semiquinone and hydroxyl radicals by visible light. | when diaziquone was irradiated with 500 nm visible light, hydroxyl free radicals as well as the diaziquone semiquinone were produced. the diaziquone semiquinone is a stable free radical that exhibits a characteristic 5-line electron spin resonance (esr) spectrum. since hydroxyl free radicals are short lived, and not observable by conventional esr, the nitrone spin trap 5,5-dimethyl-1-pyrroline-1-oxide (dmpo) was used to convert hydroxyl radicals into longer lived esr detectable spin adducts. the ... | 2010 | 2998365 |
| identification and molecular analysis of a third aspergillus nidulans alcohol dehydrogenase gene. | an aspergillus nidulans functional cdna encoding an alcohol dehydrogenase (adh) was isolated by its ability to complement an adh1 mutation in saccharomyces cerevisiae. alignment of the cdna and cloned genomic dna sequences indicated that the adh gene contains two small introns. the presence of ethanol in the growth medium was shown to result in adh mrna accumulation presumably due to transcriptional induction of the gene. however, adh mrna accumulation was at most only partially repressed by the ... | 1985 | 2998782 |
| epidemic of lav/htlv iii infection in drug addicts in milan: serological survey and clinical follow-up. | a clinico-epidemiological study is reported concerning a group of 306 parenteral drug addicts (pdas), 71 of whom were affected with the lymphadenopathy syndrome (las); all were followed-up between 1981 and 1984. although full-blown acquired immune deficiency syndrome (aids) was observed only in one case, none of the other patients examined have undergone complete recovery so far. the results of our study point to a wide circulation of lav/htlv iii among our group of pdas, starting at least as ea ... | 1985 | 2999002 |
| pyrimidinones. 1. 2-amino-5-halo-6-aryl-4(3h)-pyrimidinones. interferon-inducing antiviral agents. | interferon induction and antiviral activity was discovered with 2-amino-5-bromo-6-phenyl-4(3h)-pyrimidinone. an analogue study incorporating a series of 2-amino-5-substituted-6-arylpyrimidinones revealed that the most potent interferon inducers were mono- and difluorophenyl analogues. these same analogues were also potent antiviral agents against semliki forest virus and herpes simplex type 1. in addition the monomethoxyphenyl analogues were potent antiviral agents but weak interferon inducers. ... | 1985 | 2999405 |
| collagen accumulation can continue with decreased prolyl hydroxylase activity in the liver. | a single dose of dimethylnitrosamine dose-relatedly increased total hepatic hydroxyproline content in rats 14 days after the dosing. in cases of 35 mg/kg of dimethylnitrosamine, it increased rapidly to 1.7 times the normal level within 14 days. this increase persisted thereafter until 84 days. hepatic collagen prolyl hydroxylase activity was 1.8 times the normal level by the fourth day after the dosing but normalized within 14 days. it decreased further to levels significantly lower than those i ... | 1985 | 2999546 |
| cutaneous histiocytosis syndromes. | cutaneous histiocytosis may take two principal forms. it is either a benign proliferative process or a relentless, progressive process with a poor prognosis. in histiocytic medullary reticulosis, histiocytes demonstrate nuclear atypia and the outcome is uniformly fatal. benign cephalic histiocytosis x causes lesions similar to those of histiocytosis x, but langerhans' cells are absent. in congenital self-healing histiocytosis x, the letterer-siwe-like cutaneous infiltrate contains langerhans' ce ... | 2009 | 2999740 |
| [value of computerized tomography for the assessment of the parametrium in cervical cancer]. | the clinical and ct appearances of the parametrium in 79 patients with carcinoma of the cervix were compared with the histological findings obtained at surgery. the accuracy of ct in stages t1/t2a was 46.6%, in category t2b 64.9% and in category t3b 66.6%. clinical examination showed fewer errors. ct does not contribute to the evaluation of infiltration of the parametrium from carcinoma of the cervix, nor can it correct the findings on palpation. tumour infiltration and operability are not demon ... | 2010 | 2999892 |
| 13c and proton nmr studies of horse cytochrome c. assignment and temperature dependence of methyl resonances. | the 13c and proton chemical shifts of the 55 methyl groups of horse cytochrome c have been determined over a range of temperatures both in the diamagnetic ferrocytochrome and in the paramagnetic ferricytochrome. specific assignments of many proton resonances have been published previously and all of the remaining methyl proton resonances are now specifically assigned. the corresponding 13c assignments follow directly, including those of contact shifted 13c resonances which are reported for the f ... | 1986 | 3000825 |
| the gene for human p53 cellular tumor antigen is located on chromosome 17 short arm (17p13). | a clone that cross-hybridizes with a mouse p53 probe has been isolated from a cdna library of simian virus 40-transformed human fibroblasts. this cloned human p53 cdna was used as a probe to examine dnas obtained from human-rodent somatic cell hybrids that have segregated human chromosomes. the results show that the human p53 gene is located on chromosome 17. in addition, southern analysis of hybrids prepared from human cells containing a chromosome 17 translocation allowed regional localization ... | 1986 | 3001719 |
| nucleotide sequence of the escherichia coli dnaj gene and purification of the gene product. | the dnaj and dnak genes are essential for replication of escherichia coli dna, and they constitute an operon, dnaj being downstream from dnak. the amount of the dnaj protein in e. coli is substantially less than that of the dnak protein, which is produced abundantly. in order to construct a system that over-produces the dnaj protein, we started our study by determining the dna sequence of the entire dnaj gene, and an operon fusion was constructed by inserting the gene downstream of the lambda pl ... | 1986 | 3003084 |
| effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation. | administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (bha) or 5-(p-methoxyphenyl)-3h-1,2-dithiol-3-thione (adt) to female cd-1 mice starting 4 weeks after infection with 70 cercariae of schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. the cellular composition of the granuloma was not altered by treatment with these two compounds. the administration of the specific superoxide scavenger copper diisopropylsalicylate (cudips ... | 1985 | 3005948 |
| effects of anethole dithiolthione and 2(3)-tert-butyl-4-hydroxyanisole on schistosome granuloma formation. | administration of the antioxidants 2(3)-tert-butyl-4-hydroxyanisole (bha) or 5-(p-methoxyphenyl)-3h-1,2-dithiol-3-thione (adt) to female cd-1 mice starting 4 weeks after infection with 70 cercariae of schistosoma mansoni resulted in a decrease in the size of the inner fibrotic region of the hepatic granuloma. the cellular composition of the granuloma was not altered by treatment with these two compounds. the administration of the specific superoxide scavenger copper diisopropylsalicylate (cudips ... | 1985 | 3005948 |
| identification and solubilization of atrial natriuretic factor receptors in human placenta. | specific high affinity 125i-atrial natriuretic factor binding sites have been identified in human placental membranes. using the nonionic detergent, triton x-100, these binding sites were quantitatively solubilized and retained binding activity. in the solubilized preparation, the macromolecular component that binds atrial natriuretic factor is a 160,000 dalton protein as shown by covalently cross-linking it to 125i-atrial natriuretic factor with the bifunctional chemical crosslinker, disuccinim ... | 1986 | 3008723 |
| peptidergic modulation of a neuromuscular junction in aplysia: bioactivity and immunocytochemistry. | three endogenous peptides were assayed for bioactivity at an aplysia neuromuscular junction. evoked contractions were enhanced by phe-met-arg-phe-nh2 (fmrfamide) and suppressed by arginine vasotocin; small cardioactive peptide b (scpb) also enhanced contractions at low concentrations, but caused suppression at higher doses. in accordance with their putative roles as neuromodulators, immunocytochemistry revealed fmrfamide-like and scpb-like fibers on the muscle surface. | 2010 | 3011188 |
| peptidergic modulation of a neuromuscular junction in aplysia: bioactivity and immunocytochemistry. | three endogenous peptides were assayed for bioactivity at an aplysia neuromuscular junction. evoked contractions were enhanced by phe-met-arg-phe-nh2 (fmrfamide) and suppressed by arginine vasotocin; small cardioactive peptide b (scpb) also enhanced contractions at low concentrations, but caused suppression at higher doses. in accordance with their putative roles as neuromodulators, immunocytochemistry revealed fmrfamide-like and scpb-like fibers on the muscle surface. | 2010 | 3011188 |
| molecular cloning and restriction endonuclease mapping of the rat cytomegalovirus genome. | rat cytomegalovirus (rcmv) dna was cleaved by restriction endonuclease ecori into 24 fragments ranging in mol. wt. from 34 x 10(6) to 0.20 x 10(6), of which 18 fragments could be cloned in plasmid pacyc 184. restriction endonuclease xbai cleaved the rcmv genome into 28 fragments, ranging in size from 44 x 10(6) to 0.81 x 10(6), of which 24 fragments were cloned in plasmid psp62-pl. among the restriction fragments that could not be cloned were two major terminal colinear fragments, ecori-a (34 x ... | 1986 | 3014047 |
| sindbis and west nile virus infections in the witwatersrand-pretoria region. | from mid-december 1983 until mid-april 1984, there was an epidemic of sindbis (sin) virus infection in the witwatersrand-pretoria region in which hundreds of human cases were diagnosed clinically. twenty-eight of these diagnoses were confirmed in the laboratory by seroconversion as being infections with sin virus, and 5 cases of infection with west nile (wn) virus were also found. attempts to isolate virus from 66 patients, mainly from serum specimens, were unsuccessful. infection rates for the ... | 1986 | 3016922 |
| catabolism of intracellular protein: molecular aspects. | all living cells regulate the content and composition of their resident proteins, but the mechanisms by which this is accomplished are not understood. the process of protein degradation has an important role in determining steady state and fluctuations of protein concentrations in mammalian cells. this process may be regulated by innate properties of the protein substrates, by factors that interact or "brand" proteins for degradation or by the degradative machinery of the cell. for a specific pr ... | 2011 | 3017118 |
| [experimental nephritis induced by coxsackie b4 virus in mice--transient mesangial proliferation associated with acute viremia]. | 1986 | 3018334 | |
| cerebral cortical gaba and benzodiazepine binding sites in genetically seizure prone rats. | adult male and female genetically seizure-prone rats were assessed for sound-induced seizures. heterozygous control groups were compared with mild seizure (designated gepr 3) and severe seizure animals (gepr 9). groups of animals were killed and crude synaptosome fractions (p2) prepared from freshly dissected cerebral cortices. binding sites for gamma-aminobutyric acid (gaba) were assessed by [3h]-muscimol in the absence or presence of excess gaba and/or pentobarbital. binding sites for benzodia ... | 1986 | 3018415 |
| [components of the outer membrane of yersinia pseudotuberculosis and their role in the pathogenesis of pseudotuberculosis]. | the pore-forming protein, lipopolysaccharide-protein complex and lipopolysaccharide of y. pseudotuberculosis outer membrane have been shown to participate in the penetration of the bacteria into the cells of the macroorganism, to produce a toxic effect on these cells and to enhance the ingesting activity of macrophages in small doses, while suppressing it in large doses. when introduced parenterally, protein induces a more pronounced clinical picture of specific reactive hepatitis in experimenta ... | 1986 | 3019047 |
| eponyms in oncology. max wilms (1867-1918). | 2010 | 3019781 | |
| eponyms in oncology. max wilms (1867-1918). | 2010 | 3019781 | |
| an improved synthesis of (3-n-[11c]methyl)spiperone. | an improved radiochemical synthesis of (3-n-[11c]methyl) spiperone is reported. the radiotracer was prepared by n-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (c-18 hplc). the average radiochemical yield was approximately 21% end-of-synthesis (eos) with an average specific activity of over 2750 mci/mumol eos. the total time for synthesis and ... | 2010 | 3019944 |
| an improved synthesis of (3-n-[11c]methyl)spiperone. | an improved radiochemical synthesis of (3-n-[11c]methyl) spiperone is reported. the radiotracer was prepared by n-alkylation of spiperone in dimethylformamide in the presence of equimolar aqueous tetrabutylammonium hydroxide and was purified by semi-preparative reversed phase high performance liquid chromatography (c-18 hplc). the average radiochemical yield was approximately 21% end-of-synthesis (eos) with an average specific activity of over 2750 mci/mumol eos. the total time for synthesis and ... | 2010 | 3019944 |
| [biochemistry of amino acid derivatives of [103ru] ruthenocene. comparison with 131i hippuran]. | the potential radiopharmaceuticals: ruthenocenoyl alanine, ruthenocenoyl methionine, 1'-methyl-ruthenocenoyl glycine and its esters were labelled with 103ru starting from the analogous ferrocene compounds. in a series of tests in mice and rats these substances were compared with hippuran and ruppuran (= ruthernocenoyl glycine, a ruthenocene-amino acid analogue of hippuran). the organ distribution of these compounds was measured at various times after injection. kidney concentrations of 1'-methyl ... | 1986 | 3019949 |
| [biochemistry of amino acid derivatives of [103ru] ruthenocene. comparison with 131i hippuran]. | the potential radiopharmaceuticals: ruthenocenoyl alanine, ruthenocenoyl methionine, 1'-methyl-ruthenocenoyl glycine and its esters were labelled with 103ru starting from the analogous ferrocene compounds. in a series of tests in mice and rats these substances were compared with hippuran and ruppuran (= ruthernocenoyl glycine, a ruthenocene-amino acid analogue of hippuran). the organ distribution of these compounds was measured at various times after injection. kidney concentrations of 1'-methyl ... | 1986 | 3019949 |
| nucleotide sequence of rhizobium meliloti rcr2011 genes involved in host specificity of nodulation. | a 6 kb dna segment of the r. meliloti 2011 psym megaplasmid, which contains genes controlling host specificity of root hair infection and of nodulation, was cloned and sequenced. the dna sequence analysis, in conjunction with previous genetic data, allowed identification of four nod genes designated as e, f, g and h. nodh is divergently transcribed with respect to nodfe and nodg. a conserved nucleotide sequence was found around 200 bp upstream of the translation start of nodf, nodh and noda. thi ... | 1986 | 3020515 |
| nucleotide sequence of rhizobium meliloti rcr2011 genes involved in host specificity of nodulation. | a 6 kb dna segment of the r. meliloti 2011 psym megaplasmid, which contains genes controlling host specificity of root hair infection and of nodulation, was cloned and sequenced. the dna sequence analysis, in conjunction with previous genetic data, allowed identification of four nod genes designated as e, f, g and h. nodh is divergently transcribed with respect to nodfe and nodg. a conserved nucleotide sequence was found around 200 bp upstream of the translation start of nodf, nodh and noda. thi ... | 1986 | 3020515 |
| exposure of sheep to natural aerosols of foot-and-mouth disease virus. | sheep taken individually and allowed to inhale air being drawn along a duct from a cabinet containing pigs acutely infected with foot-and-mouth disease virus for 10 or 15 minute periods were infected by doses as low as 10 tcid50 of virus. the most consistent and reliable indicators of infection were viraemia and seroconversion. the mean times from exposure to onset of viraemia, pyrexia and the appearance of vesicular lesions were 2.5, 3.8 and 4.7 days, respectively. neither the time from exposur ... | 1986 | 3020658 |
| [multilevel structure isolation using modules based on the example of thoracic radiography]. | conventional chest radiographs were digitized and processed by multilevel band pass filtering. by this procedure different structural components are isolated according to their local spatial frequencies. in chest radiographs a textural component can be separated from a skeletal component. evaluation of radiological images is facilitated because changes can be looked for at relevant levels. a reconstruction of the image is possible, using different weighting factors to enhance interesting structu ... | 2011 | 3025963 |
| tifluadom, a kappa-opiate agonist, acts as a peripheral cholecystokinin receptor antagonist. | tifluadom, a benzodiazepine kappa-opiate agonist, stereoselectively inhibited the binding of 125i-cck to pancreatic membranes (ic50 = 47 nm). several other opiate agonists were ineffective. scatchard analysis indicated the inhibition of cck binding by tifluadom was competitive in nature. tifluadom (1 microm) did not displace 125i-cck binding to brain tissue or 125i-gastrin binding to fundic glands. in the isolated guinea pig gallbladder, tifluadom antagonized cck-8 induced contractions with an e ... | 1986 | 3027627 |
| primary biliary cirrhosis: assessment of the quantitative importance of the adenine nucleotide translocator protein as a major mitochondrial antigen. | the adenine nucleotide translocator protein (ant) is the first well-characterized mitochondrial polypeptide to be identified as an antigen for antimitochondrial autoantibodies (ama) in pbc sera. because of the potential use for a highly purified antigen as a tool in studying the aetiology of pbc, we have undertaken an assessment of the quantitative importance of ant as a pbc-specific mitochondrial antigen. immunoblotting and elisa techniques were used. both methods reveal pbc antibodies against ... | 1986 | 3028680 |
| primary biliary cirrhosis: assessment of the quantitative importance of the adenine nucleotide translocator protein as a major mitochondrial antigen. | the adenine nucleotide translocator protein (ant) is the first well-characterized mitochondrial polypeptide to be identified as an antigen for antimitochondrial autoantibodies (ama) in pbc sera. because of the potential use for a highly purified antigen as a tool in studying the aetiology of pbc, we have undertaken an assessment of the quantitative importance of ant as a pbc-specific mitochondrial antigen. immunoblotting and elisa techniques were used. both methods reveal pbc antibodies against ... | 1986 | 3028680 |
| neuroendocrine and other studies of the mechanism of antidepressant action of desipramine. | it is not known whether in depressed patients antidepressant treatment increases or reduces monoaminergic neurotransmission. clinical studies are therefore reviewed that investigate adaptive changes at adrenoceptors in depressed patients treated with desipramine, and the net effect of these changes upon neurotransmission. although in animals chronic desipramine treatment enhances the responsiveness of alpha 1-adrenoceptors to phenylephrine, no such effect could be demonstrated in patients upon t ... | 2010 | 3028722 |
| neuroendocrine and other studies of the mechanism of antidepressant action of desipramine. | it is not known whether in depressed patients antidepressant treatment increases or reduces monoaminergic neurotransmission. clinical studies are therefore reviewed that investigate adaptive changes at adrenoceptors in depressed patients treated with desipramine, and the net effect of these changes upon neurotransmission. although in animals chronic desipramine treatment enhances the responsiveness of alpha 1-adrenoceptors to phenylephrine, no such effect could be demonstrated in patients upon t ... | 2010 | 3028722 |
| the chicken carbonic anhydrase ii gene: evidence for a recent shift in intron position. | the complete nucleotide sequence of the coding region of the chicken carbonic anhydrase ii (ca ii) gene has been determined from clones isolated from a chicken genomic library. the sequence of a nearly full length chicken ca ii cdna clone has also been obtained. the gene is approximately 17 kilobase pairs (kb) in size and codes for a protein that is comprised of 259 amino acid residues. the 5' flanking region contains consensus sequences commonly associated with eucaryotic genes transcribed by r ... | 1987 | 3029691 |
| on the fidelity of dna replication: herpes dna polymerase and its associated exonuclease. | procaryotic dna polymerases contain an associated 3'----5' exonuclease activity which provides a proofreading function and contributes substantially to replication fidelity. dna polymerases of the eucaryotic herpes-type viruses contain similar associated exonuclease activities. we have investigated the fidelity of polymerases purified from wild type herpes simplex virus, as well as from mutator and antimutator strains. on synthetic templates, the herpes enzymes show greater relative exonuclease ... | 1987 | 3029700 |
| [effect of thymosin on afferent transmission in the somatosensory system of macaca rhesus]. | 2010 | 3030681 | |
| [effect of thymosin on afferent transmission in the somatosensory system of macaca rhesus]. | 2010 | 3030681 | |
| arachidonic acid inhibits phosphate transport by cultured renal cells. | because arachidonic acid and its metabolites are reported to be intracellular messengers of various exogenous stimuli, we studied whether arachidonic acid influences phosphate transport by cultured mouse renal epithelial cells. arachidonic acid, at 10(-7)-10(-4)m, inhibited phosphate transport without influencing cyclic adenosine 3':5'-monophosphate production. nordihydroguaiaretic acid and indomethacin, inhibitors of arachidonic acid metabolism, did not cancel the arachidonic acid-induced inhib ... | 1987 | 3032193 |
| arachidonic acid inhibits phosphate transport by cultured renal cells. | because arachidonic acid and its metabolites are reported to be intracellular messengers of various exogenous stimuli, we studied whether arachidonic acid influences phosphate transport by cultured mouse renal epithelial cells. arachidonic acid, at 10(-7)-10(-4)m, inhibited phosphate transport without influencing cyclic adenosine 3':5'-monophosphate production. nordihydroguaiaretic acid and indomethacin, inhibitors of arachidonic acid metabolism, did not cancel the arachidonic acid-induced inhib ... | 1987 | 3032193 |
| phosphatidylethanolamine methyltransferase and camp, cgmp phosphodiesterases in lymphocytes and monocytes in sarcoidosis. | among the various hypotheses proposed to explain immune cell defect in sarcoidosis, we examined thoroughly that of faguet who described abnormalities of signal transmission at lymphocyte membrane level. phosphatidylethanolamine methyltransferase and camp cgmp phosphodiesterases were studied in blood lymphocytes and monocytes from 8 subjects with sarcoidosis disease. phosphatidylethanolamine methyltransferase (pmt1) plays an important regulatory role in membrane signal transmission. camp and cgmp ... | 2010 | 3034451 |
| the predicted primary structure of the peplomer protein e2 of the porcine coronavirus transmissible gastroenteritis virus. | the complete nucleotide sequence of cloned cdnas containing the e2 glycoprotein-encoding region of the genome of transmissible gastroenteritis virus (tgev) has been determined. a single large translatable frame of 4.3 kb starting at 8.2 kb from the 3' end of the genome was identified. its deduced amino acid sequence contains the characteristic features of a coronavirus peplomer protein: the precursor polypeptide of tgev e2 is 1447 residues long (i.e. 285 longer than the avian infectious bronchit ... | 1987 | 3037011 |
| a factor discriminating between the wild-type and a mutant polyomavirus enhancer. | enhancers increase the frequency of transcription initiation from linked promoter elements, most probably as a result of the binding of specific proteins to the enhancer. the polyomavirus early region is expressed in differentiated mouse cells but not in undifferentiated embryonal carcinoma (ec) cells. this host range is a function of the enhancer because polyomavirus mutants selected for growth in ec cells have mutations in the enhancer and the host range is reproduced in transfection assays us ... | 1987 | 3037380 |
| three primary neoplasms in a goat: hepatocellular carcinoma, phaeochromocytoma and leiomyoma. | a ten-year-old male nubian goat with no previous medical history was found recumbent. clinical examination revealed an underweight, dehydrated, very depressed and unresponsive animal. at necropsy, the liver contained multiple, well-demarcated hepatocellular carcinomas. the right adrenal gland contained a solitary phaeochromocytoma. multiple leiomyomas were present within the urinary bladder. the three primary neoplasms reported in this goat have been reported separately in other species; their s ... | 1987 | 3038970 |
| carotid artery vasospasm complicating extensive skull base surgery: cause, prevention, and management. | arterial spasm is rarely encountered in the uncomplicated cervical lymphadenectomy. intense, often dramatic, vasospasm of the internal carotid artery, however, is not infrequently observed in the removal of skull-base lesions. this myogenic reaction is independent of autonomic innervation, occurs more frequently in younger patients, and appears to be due mainly to longitudinal arterial traction and prolonged arterial contact with fresh blood. a case of severe internal carotid artery spasm, which ... | 2011 | 3039441 |
| nucleotide sequence analysis of cellular flanking regions of intracisternal a-particle gene 81. | the cellular nucleotide sequences flanking the mouse intracisternal a-particle gene 81 were determined. the results indicated that they were made of many small oligonucleotide repeats both direct and indirect in orientation. these two different kinds of repeating sequences were often found to be overlap. the overall base composition of this region is relatively a + t rich. the most important feature of the sequences determined was that it consists of several repeated dinucleotide tracts containi ... | 1987 | 3039560 |
| the effect of lead on chemical- and viral-induced tumor production in mice. | female swiss mice were exposed to lead in the drinking water at concentrations ranging from 0 to 1000 ppm for 105 or 280 day periods of time. the effect of lead on urethan-induced pulmonary adenoma formation was evaluated in the 105 day study. urethan-induced sleeping times observed following ip injection of urethan (1.5 mg/g) after 3 weeks of lead exposure were not altered by lead indicating that lead did not affect the rate of urethan elimination. pulmonary adenoma formation was evaluated 84 d ... | 1987 | 3040844 |
| biphasic radiation-sensitivity of the transplantation immunity for rejection of an allogeneic ascites tumor. | transplantation immunity for second-set rejection of an allogeneic ascites tumor was induced by sensitizing mice with h-2-identical allogeneic spleen cells, and radiation-sensitivity of this immunity was studied. the immunity was not severely affected by 400 rads whole-body x-ray irradiation given at one day before the initial antigenic stimulation. in contrast, it was totally inactivated by 300-400 rads irradiation that was given one day before tumor challenge. an adoptive cell transfer experim ... | 2011 | 3042613 |
| increased virulence of yersinia pseudotuberculosis by two independent mutations. | a chromosomally encoded protein, which mediates invasion into hela cells was recently identified in yersinia pseudotuberculosis. the role of this protein (invasin) in the virulence process was not, however, investigated. we show that mutation of the invasin gene in y. pseudotuberculosis abolishes the ability of the bacteria to invade hela cells. when mice were challenged by intraperitoneal injection both the mutant and the wild-type strain produced infections of similar virulence but mutant show ... | 1988 | 3043229 |
| efficacy of oral acyclovir treatment of acute herpes zoster. | oral acyclovir, 800 mg five times per day for seven days, was compared with placebo in a randomized, double-blind trial conducted at three centers in the united kingdom. the study group consisted of 364 elderly immunocompetent patients with herpes zoster who were entered within 72 hours of the onset of rash. acyclovir significantly reduced the times to last new lesion formation (p less than 0.01), loss of vesicles (p less than 0.01), and full crusting (p = 0.03). no significant hastening of rash ... | 2011 | 3044098 |
| [yersinia infection]. | 1988 | 3044839 | |
| yersinia pseudotuberculosis ileitis presenting with severe intestinal haemorrhage. | 1988 | 3045318 | |
| [clinical characteristics of pseudotuberculosis in the presence of opisthorchis infestation]. | 1988 | 3045510 | |
| the power over death. | 2010 | 3045617 | |
| the power over death. | 2010 | 3045617 | |
| [use of a genetically labelled strain for the analysis of yersinia pseudotuberculosis population dynamics in natural soils]. | the rifr mutant of y. pseudotuberculosis, capable of producing pure cultures in media with a high content of rifampicin, has been used for an accurate quantitation of this microorganism in various kinds of natural (nonsterile) soil in controlled laboratory and field experiments. the main biological characteristics of the mutant have been identical to those of the parent strain. the first experiments have shown that the initially high concentration of y. pseudotuberculosis in the soil gradually d ... | 1988 | 3046193 |
| [chemotaxis of yersinia pseudotuberculosis as a mechanism in its search for target tissues of the host organism]. | y. pseudotuberculosis cells grown at biologically low temperature have been shown capable of chemotaxis with respect to carbohydrates and amino acids. during cultivation at 36-37 degrees c y. pseudotuberculosis cells retain this property for 10-15 hours and then lose it. the mechanism of chemotaxis makes it possible for y. pseudotuberculosis to "find" human and animal tissues and can facilitate the realization of the pathogenicity potential of these bacteria. when administered orally to mice mot ... | 1988 | 3046198 |
| effects of estrogen on hypothalamic gonadotropin-releasing hormone release in castrated male rhesus macaques. | the evidence that hypothalamic gonadotropin-releasing hormone (gnrh) release increases during the estrogen-induced luteinizing hormone (lh) surge in castrated female macaques and that estrogen induces a similar lh surge in the male suggests that either sexual differentiation of gnrh secretion does not exist or that changes in brain gnrh are not critical for ovulation. we tested this hypothesis by using the push-pull perfusion (ppp) technique to monitor gnrh release in the mediobasal hypothalamus ... | 1988 | 3048539 |
| the endocrine responses to general anesthesia. | 2011 | 3049390 | |
| the role of substitutes in policy analysis: acute care services in state medicaid programs. | using four acute care equations (inpatient, physician, outpatient, and clinic) from a larger model of medicaid, this research examines the "contents" of policy outcomes. this closer examination of outcomes brings to light the interactions between redistributive programs and services and the role of substitutes and complements in state-level policy analysis. (a substitute is a benefit or service that can be used instead of another to produce a similar outcome; a complement is a benefit or service ... | 2011 | 3049773 |
| botulinum toxin a-induced protective ptosis in corneal disease. | botulinum toxin a produces a temporary, flaccid ptosis when injected into the levator palpebrae superioris muscle. the resulting protective ptosis was used to aid healing in 21 cases of indolent ulceration, and, prophylactically, in 4 cases of neuroparalytic keratitis. of the indolent ulcers, 90% healed completely. in all but one case, the cornea was covered completely by the lid and complete ptosis was produced in 75% of cases in an average of 3.6 days, lasting for 16 days on average before rec ... | 2011 | 3050691 |
| the first international standard for antibodies to double stranded dna. | this paper announces the availability of the first international standard for anti-double-stranded dna (anti-dsdna). the material, coded wo/80, was obtained after recalcification of plasma taken from a patient with systemic lupus erythematosus. vials were filled with 500 microliters serum and freeze dried. the serum contains no other autoantibodies in measurable quantities. the vials should be stored at -20 degrees c. the standard should be used for establishing national, regional, or local stan ... | 2011 | 3052322 |