Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [unusual variant of laryngeal squamous cell carcinoma: verrucous carcinoma]. | verrucous carcinoma is an uncommon but distinctive variety of squamous cell carcinoma, accounting for 1 to 2% of all laryngeal neoplasms. it was first described as a distinct clinicopathological entity by ackerman in 1948. it has been described most frequently in oral cavity and larynx, but other sites are possible. the preferred location of verrucous carcinoma of the larynx is supraglottic. its general similarity with papillomas and other papillomavirus-induced lesions has raised the question o ... | 1998 | 9707746 |
| metastatic cervical carcinoma mimicking kidney abscess. | a 26-year-old female, who had been treated for cervical carcinoma, presented with high fever and right flank pain. a right renal abscess was initially suspected from the clinical symptoms and diagnostic imaging. however, pathologic findings for the right kidney revealed squamous cell carcinoma, which was consistent in type with the original cervical carcinoma. demonstration of human papillomavirus 16 in tissues from both the renal tumor and the cervical carcinoma confirmed that the right kidney ... | 1998 | 9712449 |
| translational inhibition in vitro of human papillomavirus type 16 l2 mrna mediated through interaction with heterogenous ribonucleoprotein k and poly(rc)-binding proteins 1 and 2. | human papillomavirus (hpv) type 16 belongs to the group of "high risk" hpv types that are frequently detected in anogenital cancers. the expression of hpv-16 late genes encoding the virus capsid proteins l1 and l2 is restricted to terminally differentiated epithelial cells in the superficial layers of the squamous epithelium. we have previously identified negative elements in the 3' end of l2 rna that act in cis to reduce mrna utilization without substantially affecting mrna levels. the experime ... | 1998 | 9712894 |
| comparison of human papillomavirus type 18 (hpv-18) e6-mediated degradation of p53 in vitro and in vivo reveals significant differences based on p53 structure and cell type but little difference with respect to mutants of hpv-18 e6. | an important characteristic of the e6 proteins derived from oncogenic associated human papillomaviruses (hpvs) is their ability to target the cellular tumour suppressor protein, p53, for ubiquitin mediated degradation. several studies have attempted to address the important characteristics of both e6 and p53 for this activity in vitro, but the equivalent determinants have not been extensively assessed in vivo. indeed, recent studies indicate differences between the in vitro and the in vivo degra ... | 1998 | 9714244 |
| management of female genital warts with an analog of imiquimod 2% in cream: a randomized, double-blind, placebo-controlled study. | the purpose of this randomized, double-blind, placebo-controlled study was to determine the clinical efficacy and tolerability of an analog of imiquimod (2%)in cream to cure genital warts in women. sixty preselected women, ranging between 18 and 45 years of age (mean 24.3) and having 411 lesions (mean 6.8) with clinical, histopathological and polymerase chain reaction (pcr) confirmed diagnosis of human papilloma virus (hpv) infection were randomized to two parallel groups. each patient received ... | 1998 | 9714974 |
| uncoupling of p21waf1/cip1/sdi1 mrna and protein expression upon genotoxic stress. | the p21waf1/cip1/sdi1 gene is an important regulator of crucial cellular processes, including cell cycle control, cellular differentiation, and the response to genotoxic stress. induction of p21 gene expression upon dna damage is widely believed to be p53-dependent. in the present study we analysed the expression of p21 following genotoxic stress, using different dna-damaging agents and cellular systems. we found that the p21 response markedly varied between different cell lines and also for dif ... | 1998 | 9715280 |
| establishment of an epidermal growth factor-dependent, multipotent neural precursor cell line. | we have established a multipotent clonal cell line, named meb5, from embryonic mouse forebrains after the infection of a retrovirus carrying e7 oncogene of human papillomavirus type 16. meb5 cells proliferated in serum-free, epidermal growth factor (egf)-supplemented medium. they expressed markers for neural precursor cells (nestin, a2b5, and rc1) and did not express markers for neurons (class iii beta-tubulin), astrocytes (glial fibrillary acidic protein), and oligodendrocytes (galactocerebrosi ... | 1998 | 9719419 |
| suppression of senescence in normal human fibroblasts by introduction of dominant-negative p53 mutants or human papilloma virus type 16 e6 protein. | transfection of nearly senesced human fibroblasts with plasmids encoding hpv16 e6 protein or dominant-negative p53 mutants greatly increased their colony-forming ability. isolated colonies with these plasmids showed extension of lifespan compared to those with a control plasmid. these data demonstrate that p53 plays a major role in senescence in normal human fibroblasts. | 1998 | 9720232 |
| temporal and spatial expression of the e5a protein during the differentiation-dependent life cycle of human papillomavirus type 31b. | human papillomaviruses (hpvs) are epitheliotropic viruses, and their life cycle is intimately linked to the stratification and differentiation state of the host epithelial tissues. defining a role for the e5 gene product in the differentiation-dependent viral life cycle has been difficult due to the lack of a suitable culture system. we used the organotypic (raft) culture system to investigate the spatial and temporal expression pattern of the e5 protein during the differentiation-dependent life ... | 1998 | 9721230 |
| human papillomavirus type 31b e1 and e2 transcript expression correlates with vegetative viral genome amplification. | human papillomavirus (hpv) genome replication is dependent on the expression of e1 and e2 proteins. the organotypic (raft) culture system was used to investigate changes in viral early gene expression and vegetative genome replication during the complete life cycle of hpv type 31b (hpv31b). we have previously shown the synthesis of hpv31b viral particles as early as 10 days of growth of cin-612 9e raft tissues (ozbun, m. a., and meyers, c. (1997). j. virol. 71, 5161-5172). in the present study, ... | 1998 | 9721231 |
| the "inconclusive--possible high grade epithelial abnormality" category in papanicolaou smear reporting. | the australian terminology for cervical cytology reporting includes the category "inconclusive-possible high grade epithelial abnormality." | 1998 | 9723595 |
| early regression of cervical lesions in hiv-seropositive women receiving highly active antiretroviral therapy. | advanced hiv disease is associated with a high prevalence of cervical squamous intra-epithelial lesions (sil) and of infection with oncogenic human papillomavirus (hpv) genotypes. triple-combination antiretroviral therapy results in decreased plasma hiv viral load, increased cd4 cell counts and partial restoration of immune functions in patients with severe hiv disease. this study investigated the outcome of sil in hiv-seropositive women undergoing triple combination antiretroviral treatment. | 1998 | 9727566 |
| immunohistochemical co-expression of human papillomavirus type 16/18 transforming (e6) oncoprotein and p53 tumour suppressor gene proteins in oesophageal cancer. | human papillomaviruses have been widely implicated as important etiologic agents in various squamous cell carcinomas including oesophageal carcinoma. p53 mutant oncoprotein has also been implicated in various tumours. immunohistochemical analysis was employed to detect the co-expression of hpv and p53 mutant protein in biopsy specimens of patients of cancer oesophagus as well as controls. this analysis revealed a significantly higher immunopositivity (63%) of e6 oncoprotein of hpv 16/18 in carci ... | 1998 | 9731468 |
| risk of anal carcinoma in situ in relation to human papillomavirus type 16 variants. | infection with human papillomavirus (hpv), especially hpv16, is central to the development of squamous anogenital cancers and their precursor lesions, termed "squamous intraepithelial neoplasias." men who have sex with men, particularly those who are infected with hiv, are at a high risk for anal infection with hpv16 and for low-grade anal neoplasia; however, only a subset of these men develop anal invasive cancer or its immediate precursor lesion, anal carcinoma in situ (cis). to examine the hy ... | 1998 | 9731493 |
| nasal immunization of mice with human papillomavirus type 16 virus-like particles elicits neutralizing antibodies in mucosal secretions. | to specifically induce a mucosal antibody response to purified human papillomavirus type 16 (hpv16) virus-like particles (vlp), we immunized female balb/c mice orally, intranasally, and/or parenterally and evaluated cholera toxin (ct) as a mucosal adjuvant. anti-hpv16 vlp immunoglobulin g (igg) and iga titers in serum, saliva, and genital secretions were measured by enzyme-linked immunosorbent assay (elisa). systemic immunizations alone induced hpv16 vlp-specific igg in serum and, to a lesser ex ... | 1998 | 9733865 |
| activity of human papillomavirus type 16 p97 promoter in immortal and tumorigenic human oral keratinocytes. | we previously immortalized normal human oral keratinocytes (nhok) by transfection with cloned human papillomavirus type 16 (hpv-16) genome and converted these immortalized cells to tumorigenic cells with chemical carcinogens. since the tumorigenic cells expressed higher level of hpv-16 e6/e7 transcripts, we predicted that enhanced e6/e7 expression was induced by mutations at the long control region (lcr) of the viral genome integrated into cellular chromosome. to test this possibility, we sequen ... | 1998 | 9735407 |
| modulation of hpv16 e7 translation by trnas in eukaryotic cell-free translation systems. | translational regulation of hpv16 e7 mrna is of particular interest since the viral e7 protein has oncogenic activity. here we report that additional supplementation of cell-free reticulocyte/wheat-germ translation systems with rat liver trna pool favors the expression of the viral oncoprotein e7 which otherwise is scarcely translatable. the translational activation is explained by the positive correlation between the frequency of the glutamic and aspartic codons in e7 mrna, and the increased co ... | 1998 | 9739465 |
| the papillomavirus e6 proteins. | specific types of human papillomaviruses (hpv) are strongly associated with the development of cervical cancer. the e6 gene from cancer-related hpvs has exhibited functions in tumorigenesis, regulation of transcription, telomerase, and apoptosis. cancer-related hpvs e6 proteins bind the tumor suppressor p53 and promotes its degradation through an ubiquitin-dependent pathway. several additional cellular e6-binding proteins have recently been identified and implicated in playing roles in p53-indep ... | 1998 | 9739758 |
| morphological and immunohistochemical aspects of the biological seal in klöckner's dental implants: study of 15 cases. | the morphological and immunohistochemical aspects of the peri-implanted pathological soft tissue of 21 klöckner implants are assessed, corresponding to 15 patients and three gingival samples from three cadavers. for the collagen and vascular walls assessment, the picro-sirio technique is used with normal microscopy as well as with polarized light, evaluating the decrease of collagen fibers in relation to the grade of inflammation. in cases when there is a plasmocyte inflammatory prevalence, anti ... | 1998 | 9743639 |
| hpv-16 e7 protein bypasses keratinocyte growth inhibition by serum and calcium. | the e6 and e7 genes of hpv-16 or hpv-18 both are necessary for effective immortalization of primary human genital keratinocytes. to analyse the individual role of e6 and e7 genes in dysregulating cell growth, we cloned the hpv-16 e6, e7 and e6/e7 genes into retroviruses. primary human keratinocytes (phk) were then infected with these retroviruses and selected in differentiation-inducing medium (high calcium and serum). the e6/e7 retroviruses were the most effective at inducing differentiation-re ... | 1998 | 9744546 |
| establishment and characterization of a strial marginal cell line maintaining vectorial electrolyte transport. | e6/e7 genes of human papilloma virus type 16 were used to immortalize a primary culture of marginal cells (mc) from gerbils. one of the cloned lines was selected which demonstrated preservation of the main characteristics of the mc, both morphologically and physiologically. electron microscopic examination showed well-developed junctional complexes and apical microvilli which suggested its epithelial origin. polymerase chain reaction (pcr) demonstrated the incorporation of e6/e7 genes with the g ... | 1998 | 9745959 |
| evaluation of the detection of human papillomavirus genotypes in cervical specimens by hybrid capture as screening for precancerous lesions in hiv-positive women. | given the frequency and persistence of human papillomavirus (hpv) infection and associated cytological alterations in hiv-1-positive women, the incidence of uterine cervix neoplasm is likely to increase along with patient survival. more appropriate screening programs, which, in addition to pap smears (ps), also include tests to detect and type hpv, are needed for the early identification of precancerous cervical lesions. this prospective study involved 168 hiv-positive (group a) and 100 hiv-nega ... | 1998 | 9746069 |
| examining the complex relationship of human papillomavirus to cervical dysplasia and carcinoma. | human papillomavirus (hpv) infection is quite common in women and is clearly the major risk factor for cervical intraepithelial neoplasia and invasive cervical cancer. hpv dna has been detected in 80% to 90% of cin 3 lesions and invasive cervical cancers. while the most common presentation is warts, or condylomata, many infections are detected only by pap smear cytologic evidence. we still do not have a clear understanding of hpv latency, reactivation, subclinical infection without apparent dise ... | 1997 | 9746693 |
| risk factors for cervical presence of human papillomavirus dna among women at risk for hiv infection. dianaids collaborative study group. | risk factors for cervical infection with human papillomavirus (hpv) were assessed among 236 italian women at risk for human immunodeficiency virus (hiv) infection (intravenous drug users (ivdu) or sexual partners of males at risk for hiv infection). all study participants underwent a structured interview, determination of hiv serostatus and detection of hpv cervical infection by means of polymerase chain reaction (pcr). overall, the cervical presence of hpv dna was ascertained in 86 of these 236 ... | 1998 | 9747769 |
| correlation between human papillomavirus dna detection in maternal cervical smears and buccal swabs of infants. | acquisition of human papillomavirus (hpv) infection in buccal mucosa by the infants at birth has been investigated. presence of hpv dna was evaluated in cervical smears of 30 pregnant women before delivery and in buccal swabs of the corresponding 31 infants (1 set of twins). hpv dna was detected among the 40% of women, 16% of infants an the detection was concordant in 23 mother-infant pairs. hpv dna was demonstrated in buccal mucosal cells of 41.6% of the infants born to hpv positive mothers. ma ... | 1998 | 9754051 |
| detection of high-risk human papillomavirus nucleic acid in archival cervical smears. | to test the usefulness of a commercial dna hybridization assay for the detection of high-risk (hr) human papillomavirus (hpv) types in archival cervical smears and to compare the sensitivity with that of polymerase chain reaction (pcr) using consensus primers. | 1998 | 9755661 |
| anogenital papillomavirus infections in children. | over the years, our impression of human papillomavirus has changed. once thought of as the cause of relatively insignificant skin lesions, its significant role in malignancy of epithelia and mucosa throughout the body is beginning to be understood. also changing, although not as rapidly as we would like is our understanding of how human papillomavirus infects the body, the concept of latency, our responses to infection, and how to modify or boost those responses so as to overcome infection. rese ... | 1998 | 9757364 |
| evaluation of atypical and low-grade cervical cytology in private practice. | to evaluate the adequacy of cytology alone for diagnosis of grade of cervical intraepithelial neoplasia (cin) and to study performance of cytology, human papillomavirus (hpv) testing, and colposcopy in the evaluation of cytologic findings suggesting low-grade squamous intraepithelial lesions (sil), or atypical squamous (ascus) or atypical glandular (agcus) cells of undetermined significance. | 1998 | 9764636 |
| hpv 16 and cigarette smoking as risk factors for high-grade cervical intra-epithelial neoplasia. | although genital human papillomavirus (hpv) infection is well established as the etiologic agent for cervical intraepithelial neoplasia (cin), little is known about the cofactors involved in the development of high-grade lesions or the progression of low-grade to high-grade lesions. in our study of hpv-infected women with cin (163 cin i, 51 cin ii and 44 cin iii), women with cin ii or iii were compared with those with cin i for risk factors associated with high-grade lesions. after controlling f ... | 1998 | 9766558 |
| in vitro propagated dendritic cells from patients with human-papilloma virus-associated preneoplastic lesions of the uterine cervix: use of flt3 ligand. | dendritic cells (dc) are the most efficient antigen presenting cells. the clinical use of dc as vectors for antitumor and anti-infectious disease immunotherapy has been limited by their low level and accessibility in normal tissue. substantial numbers of dc can be generated from peripheral blood cultured in the presence of interleukin-4 (il-4) and granulocyte/macrophage-colony-stimulating factor (gm-csf). we showed in this study that substantial numbers of dc can be obtained from the peripheral ... | 1998 | 9769116 |
| expression of the mcp-1 gene and the hpv 16 e6/e7 oncogenes in squamous cell carcinomas of the cervix uteri and metastases. | monocyte chemoattractant protein 1 (mcp-1) plays an important role in the recruitment of monocytes in solid tumors. previously, for cervical carcinoma cell lines an inverse correlation between the expression of the mcp-1 gene and the human papillomavirus (hpv) oncogenes e6/e7 was described. in this study paraffin-embedded biopsy specimens from 25 squamous cell carcinomas of the cervix uteri were analyzed for the expression of the mcp-1 gene and the hpv 16 e6/e7 oncogenes by rna/rna in situ hybri ... | 1998 | 9769472 |
| loss of heterozygosity on the short arm of chromosome 3 in cervical intra-epithelial neoplasia without concomitant cervical carcinoma. | losses of heterozygosity on the short arm of chromosome 3p are common in cervical carcinomas in the 3p13-3p21 region, and can be observed in intra-epithelial lesions accompanying cervical cancers. as a preliminary attempt to determine whether these losses can be observed in intra-epithelial cervical lesions without concomitant invasive carcinoma, we have used two microsatellite markers located at the two most frequently deleted segments of the 3p13-3p21 region. we have studied 36 cases of grade ... | 1998 | 9769478 |
| transcriptional regulation of the egf receptor promoter by hpv16 and retinoic acid in human ectocervical epithelial cells. | we have previously demonstrated that human papillomavirus 16 (hpv16)-immortalized human ectocervical epithelial cells and cells derived from tumors which express hpv16 oncogenes express high levels of epidermal growth factor receptor (egfr) compared to normal cervical cells. we have also shown that proliferation of these cells is inhibited by retinoid treatment. we have hypothesized that the retinoid inhibition of cell proliferation may be due to the retinoid-dependent reduction in egfr level. i ... | 1998 | 9770378 |
| human papillomavirus oncoproteins alter differentiation-dependent cell cycle exit on suspension in semisolid medium. | the suspension of keratinocytes containing episomal forms of the human papillomavirus (hpv)-31 genome in semisolid medium results in the induction of viral late functions. in this study, the suspension in semisolid medium was used to analyze how hpv deregulates the process of cell cycle exit during differentiation. in cells that contain the entire hpv-31 genome, induction of late protein synthesis was found to be linked with the expression of cyclin a. consistent with analyses in organotypic raf ... | 1998 | 9770416 |
| interaction of salicylic acid with verrucae assessed by ft-raman spectroscopy. | ft-raman spectroscopy has been used to investigate treated verrucae (warts from the sole of the foot) with a local application of a salicylic acid paint. differences in the molecular structure of the stratum corneum across the verruca sample were observed, and by comparison with normal and hyperkeratotic skin it was concluded that the tissue around the edges of the verrucae was typically hyperkeratotic skin. in the centre of the verruca, the molecular structure of the skin was altered showing ev ... | 1998 | 9771616 |
| the e7 protein of human papillomavirus type 16 sensitizes primary human keratinocytes to apoptosis. | the 'high risk' human papillomaviruses are associated with the development of anogenital carcinomas and their e6 and e7 genes possess immortalizing and transforming functions in several in vitro culture systems. recently the e6 gene has also been shown to enhance the apoptosis of human mammary epithelial cells. to determine the apoptotic activity of these oncogenes in the natural host cell, we infected genital keratinocytes with retroviruses expressing either hpv-16 e6, e7, or both the e6 and e7 ... | 1998 | 9771963 |
| up-regulation of p53 by antisense expression of hpv18 e6 oncogene does not influence the level of mn/ca ix tumor-associated protein in hela cervical carcinoma cells. | oncogenic potential of human papillomaviruses is related to capacity of hpv-encoded oncoproteins to bind and inactivate tumor suppressor proteins. interaction of p53 with hpv e6 results in aberrant regulation of various cellular genes. we evaluated the possible involvement of mn/ca9 gene, whose expression is closely associated with cervical carcinomas, in regulatory pathways driven by p53 and e6. we demonstrated that one of the two p53 consensus sequences present in mn/ca9 promoter participates ... | 1998 | 9772303 |
| comparison of pcr- and hybrid capture-based human papillomavirus detection systems using multiple cervical specimen collection strategies. | this study compared the performances of three human papillomavirus (hpv) detection tests with specimens collected by three alternative procedures. the hpv tests included the hybrid capture tube test (hct), the microplate-based hybrid capture ii test (hc ii), and the my09-my11 l1 consensus primer pcr-based assay. initial cervical specimens were collected from study subjects with a broom device, and after papanicolaou smears were made, residual specimens were placed into preservcyt (pc), a liquid ... | 1998 | 9774574 |
| underexpression of cyclin-dependent kinase (cdk) inhibitors in cervical carcinoma. | recent studies have revealed a new family of tumor suppressor genes that directly implicate aberrant cell cycle regulation in tumorigenesis. the general function of these gene products is that they prevent cell cycle progression by directly interfering with cyclin/cyclin-dependent kinase (cdk) activation. the importance of these genes is that they are potent inhibitors of cdk. among these cell cycle inhibitors, p21(waf1/cip1) and p16 have been thoroughly studied. however, the role of p21(waf1/ci ... | 1998 | 9784316 |
| bowenoid papulosis showing polyclonal nature. | bowenoid papulosis (bp) is characterized clinically by its benign-looking appearance and histologically by the features of high grade squamous intraepithelial lesions (sils). the external genitalia of young people is a common site of occurrence, and most of the lesions undergo resolution by local treatments or even spontaneously. a strong association between bp and high risk types of human papillomavirus (hpv), especially hpv 16, has been reported and the incorporation of bp into the sil categor ... | 1998 | 9785012 |
| does typing of human papillomavirus assist in the triage of women with repeated low-grade, cervical cytologic abnormalities? | 1998 | 9790780 | |
| l1-specific protection from tumor challenge elicited by hpv16 virus-like particles. | a single injection of hpv16 l1 virus-like particles induced potent cd8-mediated protection from tumor challenge by c3 cells, a line derived from embryonic mouse cells transfected with the hpv16 genome. l1 rna, but not protein, was detected biochemically in c3 cells. these results indicate that low-level expression of hpv16 l1 can occur in proliferating cells and serve as a tumor vaccine target. although l1 expression is generally thought to be restricted to terminally differentiated epithelial c ... | 1998 | 9792847 |
| familial risks in in situ cancers from the family-cancer database. | the swedish family-cancer database was used to analyze relationships between parents and offspring with in situ cancers and between in situ cancers in one generation and invasive cancer in the other generation. a total of 130,000 in situ cancers and close to 400,000 invasive cancers were included from 1959 to 1994. the data on family relationships and cancers came from registered sources and should be free from bias. the offsprings' familial relative risks (frrs) were calculated for concordant a ... | 1998 | 9796630 |
| condyloma acuminata: a fatal disease? | condyloma acuminata is a virally mediated epithelial overgrowth caused by the human papilloma virus. its simplest form is the common wart, which may occur almost anywhere on the body surface. its papillary lesion forms are commonly seen in the genital, perineal, and anal areas, though it also infects the conjunctiva, nose, mouth, larynx, and tracheo-bronchial tree. malignant degeneration may occur in any of these areas. diagnosis is established by clinical impression and biopsy. immunoassay meth ... | 1998 | 9798775 |
| in vivo survival of viral antigen-specific t cells that induce experimental autoimmune encephalomyelitis. | a peptide derived from the human papillomavirus l2 protein is recognized by a myelin basic protein (mbp)-specific t cell clone from a multiple sclerosis patient and by mbp-specific autoantibodies purified from multiple sclerosis brain tissue. we now show in mice that low doses of this papillomavirus peptide were optimal in selecting a subpopulation of papillomavirus peptide-specific t cells that cross-reacted with mbp(87-99) and with an unrelated viral peptide derived from the bslf1 protein of e ... | 1998 | 9802984 |
| human hsp70 and hsp40 chaperone proteins facilitate human papillomavirus-11 e1 protein binding to the origin and stimulate cell-free dna replication. | human papillomavirus replication initiator, the e1 helicase, binds weakly to the origin of dna replication. purified human chaperone proteins hsp70 and hsp40 (hdj-1 and hdj-2) independently and additively enhanced e1 binding to the origin. the interaction between e1 and hsp70 was transient and required atp hydrolysis, whereas hsp40 bound to e1 directly and remained in the complex. a peptide of 20 residues spanning the hpd loop and helix ii of the j domain of ydj-1 also stimulated e1 binding to t ... | 1998 | 9804845 |
| [viral sexually transmitted diseases and their treatments]. | in occidental countries, the sexually transmitted diseases (stds) originate mostly from virus: human papillomavirus (hpv) and herpes simplex virus (hsv). during the latest 15 to 20 years, their prevalence has been regularly growing. those viruses have in common a capacity for latency. the persistence of the virus in keratinocytes (pvh) or in ganglionic cells (hsv) and the lack of an efficient preventive or final curative treatment have several consequences: 1) a possible capacity of transmitting ... | 1998 | 9805942 |
| solitary pulmonary papillomas in adults: a clinicopathologic and in situ hybridization study of 14 cases combined with 27 cases in the literature. | solitary endobronchial papillomas in adults are rare neoplasms. only sporadic cases have been documented. the histologic classification of these tumors remains problematic, and little is known about their clinical behavior. the clinical and pathologic features of 13 endobronchial papillomas and a single endobronchiolar papilloma were reviewed. in situ hybridization for human papillomavirus (hpv) types 6/11, 16/18, and 31/33/51 was performed on seven cases. twenty-seven additional well-documented ... | 1998 | 9808125 |
| in vitro construction of pseudovirions of human papillomavirus type 16: incorporation of plasmid dna into reassembled l1/l2 capsids. | lack of permissive and productive cell cultures for the human papillomaviruses (hpvs) has hindered the study of virus-neutralizing antibodies and infection. we developed a cell-free system generating infectious hpv16 pseudovirions. hpv16 l1/l2 capsids, which had been self-assembled in insect cells (sf9) expressing virion proteins l1 and l2, were disassembled with 2-mercaptoethanol (2-me), a reducing agent, and reassembled by removal of 2-me in the presence of a beta-galactosidase expression plas ... | 1998 | 9811779 |
| genital human papillomavirus infection in women who have sex with women. | genital infection with human papillomavirus (hpv), as determined by polymerase chain reaction detection of hpv dna and prevalence of hpv-6 and -16 serum antibodies, was investigated in 149 women who were sexually active with women. by use of hpv l1 consensus primers and hybridization to types 6/11, 16, 18, 31/33/35/39, and 45 and a generic probe, hpv dna was detected in 30% of subjects; of these, 20% had type 31/33/35/39, 18% had type 16, and 2% had type 6/11. of 21 subjects reporting no prior s ... | 1998 | 9815211 |
| sexually transmitted diseases and reproductive history in women with experience of casual travel sex abroad. | background: the objective of this study was to determine whether the frequency of sexually transmitted diseases (stds) and some reproductive events in women with experience of casual travel sex (cts) abroad with previously unknown male partners differed when compared to women lacking such experience. methods: nine hundred and ninety-six women seeking contraceptive advice from two family planning clinics and a youth clinic were studied. two hundred and seventy-six of these women (27.7%) admitted ... | 1996 | 9815441 |
| inactivation of p53 increases the cytotoxicity of camptothecin in human colon hct116 and breast mcf-7 cancer cells. | camptothecin (cpt) derivatives are topoisomerase i (top1) inhibitors recently introduced as clinical agents. to explore the role of p53 in cpt-induced cytotoxicity, we examined cpt effects in two isogenic pairs of human cancer cell lines, mcf-7 breast carcinoma and hct116 colon carcinoma cells, in which p53 function had been disrupted by transfection with the human papillomavirus type-16 e6 gene. clonogenic survival assays showed that both mcf-7/e6 and hct116/e6 cells were more sensitive to cpt. ... | 1997 | 9815856 |
| p53 mutation, murine double minute 2 amplification, and human papillomavirus infection are frequently involved but not associated with each other in esophageal squamous cell carcinoma. | we examined the relationship between p53 mutation, murine double minute 2 (mdm2) gene amplification, and human papillomavirus (hpv) infection in 72 esophageal squamous cell carcinomas. we identified p53 mutations in 29 tumors (40.3%) by pcr-single-strand conformation polymorphism analysis and direct sequencing. amplification of the mdm2 gene was detected by southern blot hybridization in 13 (18.1%) of 72 tumor tissues and in 4 (33.3%) of 12 cultured esophageal squamous cell lines. all four cell ... | 1995 | 9816044 |
| suppression of cancer cell growth by adenovirus expressing p21(waf1/cip1) deficient in pcna interaction. | p53 tumor suppression is deficient in the majority of human cancers. efforts to understand this pathway have identified cyclin-dependent kinase (cdk) inhibitors and suggested a potential for their replacement in human cancer. in the present studies, expression of a c-terminal deletion mutant of the human p21(waf1/cip1) cdk inhibitor completely suppressed the growth of colon cancer cells, whereas full-length p21 only partially suppressed growth. we prepared a replication-deficient adenoviral reco ... | 1996 | 9816291 |
| colposcopic appearance of cervical intraepithelial neoplasia is age dependent. | we investigated to determine whether colposcopic, histologic, and virologic parameters of cervical intraepithelial neoplasia are influenced by a patient's age. | 1998 | 9822520 |
| trans-activating activity of the e6 proteins of the human papillomavirus (hpv) type-11 and -16 on the pe1e4 promoter of hpv-11 in c33a cells. | we investigated trans-activating effects of the full-length e6 protein of hpv-16 (16e6) and the e6 protein of hpv-11 (11e6) on the pe1e4 promoter of hpv-11 in c33a cells which lack normal function of p53. 16e6 showed no significant activation of the reporter plasmid containing pe1e4 and the upstream sequence, including the long control region (lcr). in contrast, 11e6 activated the promoter in a dose dependent manner, while relatively high doses of 11e6 were required to activate the promoter. whe ... | 1998 | 9824640 |
| molecular analysis of ras oncogenes in cin iii and in stage i and ii invasive squamous cell carcinoma of the uterine cervix. | to examine the prevalence of genital type human papilloma virus (hpv) and mutations at codons 12, 13, and 61 in h, ki, and n-ras in cin iii and early invasive squamous cell carcinomas of the cervix. | 1998 | 9828814 |
| expression of keratin 13, 14 and 19 in oral squamous cell carcinomas from sudanese snuff dippers: lack of association with human papillomavirus infection. | in stratified squamous epithelia, altered expression of keratins (ks) is one possible marker of malignant potential. in the epithelium of the uterine cervix, presence of human papillomaviruses (hpvs) is increasingly regarded as a marker of risk for cervical cancer. however, a similar role in oral cancer and precancer remains controversial. to address these questions, formalin-fixed, paraffin-embedded oral carcinomas from sudanese snuff dippers (n=14) and oral carcinomas from sudanese (n=14), swe ... | 1998 | 9833698 |
| detection and typing of human papillomavirus dna in benign and malignant tumours of laryngeal epithelium. | the role of human papillomaviruses (hpv) in laryngeal squamous cell carcinoma has not yet been established. thirty-three cases of laryngeal squamous cell carcinoma were analysed for the presence of hpv dna and compared with 25 cases of normal larynx and 29 cases of laryngeal squamous papilloma in their positivity index. the presence of hpv dna was analysed by using l1 consensus primers and also by primers specific for the e7 gene of hpv types 16 and 18. four normal laryngeal samples (16%) were p ... | 1998 | 9840518 |
| high-risk human papillomavirus infection and overexpression of p53 protein in squamous cell carcinoma of the esophagus from japan. | the present study was undertaken in order to investigate the possible involvement of high-risk human papillomavirus (hpv; types 16 and 18) or the overexpression of p53 protein in 123 japanese patients with esophageal squamous cell carcinoma (scc) from five different institutions. we detected hpv dna in 30.1% (37/123) by in situ hybridization (ish). of these 123 cases, hpv type 16 was detected in 22 cases and hpv type 18 in 23 cases. in addition, hpv types 16 and 18 were detected simultaneously i ... | 1998 | 9844797 |
| hpv and cancer: the story unfolds. | 1998 | 9846352 | |
| high prevalence of cervical intra-epithelial neoplasia in women treated for pelvic inflammatory disease. | because human papillomavirus (hpv) is sexually transmitted, as are pelvic inflammatory disease (pid) agents, the authors investigated whether cervical intra-epithelial neoplasia (cin) are more frequent in women under treatment for pid. the study involved 298 patients hospitalized for pid, in whom cin were investigated by smears and colposcopy. cin were diagnosed in 42 patients, i.e. in 14% of patients: 21 low-grade cin and 21 high-grade cin, including one case of early-stage microinvasion. these ... | 1998 | 9846714 |
| expression status of p16 protein is associated with human papillomavirus oncogenic potential in cervical and genital lesions. | the p16 protein (p16) is a cyclin-dependent kinase (cdk) inhibitor that decelerates the cell cycle by inactivating the cdks that phosphorylate retinoblastoma (rb) protein. recent biological studies have revealed that p16 expression is markedly influenced by the status of rb expression, and p16 overexpression has been demonstrated in cervical cancers because of functional inactivation of rb by human papillomavirus (hpv) e7 protein. to clarify the relationship between p16 overexpression and hpv in ... | 1998 | 9846965 |
| [hybrid tumor of the penis: is this denomination correct?]. | few cases of verrucous carcinoma of the penis with foci of invasive squamous cell carcinoma have been reported and denominated "hybrid tumors". the accuracy of this term is discussed in this paper. | 1998 | 9859589 |
| detection of hpv-16 genome in human oral cancers and potentially malignant lesions from india. | the presence of high risk human papilloma virus (hpv) 16 and 18 was examined in 100 oral cancer patients of indian descent, 80 patients with potentially malignant oral lesions and corresponding clinically normal mucosa from 48 of these patients. additionally, presence of hpv-33, -6 and -11 was also studied in 86 oral cancers, 50 potentially malignant oral lesions and 30 corresponding normal oral mucosa. all the patients with oral cancer and oral lesions, were long term tobacco-chewers, and a maj ... | 1998 | 9861351 |
| gynaecological conditions associated with hiv infection in women who are partners of hiv-positive thai blood donors. | women who were partners of hiv-positive blood donors were enrolled in a study of heterosexual hiv transmission between march 1992 and december 1996 and were interviewed and examined. gynaecological conditions, including cervical dysplasia, human papillomavirus (hpv) infection, gonorrhoea, chlamydial infection, trichomoniasis, bacterial vaginosis, vaginal candidiasis and syphilis were assessed in addition to hiv status and cd4 level. of 481 women enrolled, 224 (46.6%) were hiv seropositive. hiv-i ... | 1998 | 9863581 |
| therapeutic evaluation of compounds in the scid-ra papillomavirus model. | a previous study by kreider (kreider et al., 1979) indicated that rabbit skin, which had been transplanted to immunodeficient nude mice, could be successfully infected with cottontail rabbit papillomavirus (crpv). we have extended this observation in developing a rodent model for evaluation of compounds for activity against the papillomaviruses. in this model (called the scid-ra model), rabbit ear skin is transplanted to the dorsum of scid mice and allowed to heal for 3 weeks. infection with crp ... | 1998 | 9864047 |
| dna vaccine against oncogenic hamster cells transformed by hpv16 e6/e7 oncogenes and the activated ras oncogene. | the capability of dna to elicit anti-tumour immunity was studied using human papillomavirus type 16 (hpv16)-transformed syrian hamster cells denoted k3/ii. these cells had been derived after cotransfection of primary kidney cell cultures with p16hhmo plasmid containing e6/e7 oncogenes of hpv16 and pej6.6 plasmid containing the activated human h-ras oncogene; they express both the hpv16 and activated h-ras genes. as a dna vaccine, the p16hhmo plasmid was used. three doses of the plasmid (either 1 ... | 1999 | 9864430 |
| basal cell carcinoma of the genitalia. | basal cell carcinomas (bcc) arising on the genitalia are exceedingly rare with an unclear pathogenesis. | 1998 | 9865204 |
| specific expression of epstein-barr virus in cutaneous squamous cell carcinomas from heart transplant recipients. | we investigated a swedish group of 114 immunosuppressed cardiac allograft patients for the occurrence of posttransplant cutaneous squamous cell carcinomas. a total of 15 tumors were detected in specimens from 5 patients. | 1998 | 9869095 |
| pathology of human immunodeficiency virus infection: noninfectious conditions. | diagnostic anatomic pathologists play a crucial role in the battle against acquired immunodeficiency syndrome (aids). not only are they intimately involved in the treatment of individual patients with human immunodeficiency virus (hiv) infection, but also they make important observations that result in the expansion of the scientific understanding of its pathogenesis. pathologists studying tissue from patients with hiv infection should be familiar with the conditions to which these patients are ... | 1997 | 9869826 |
| human leukocyte derived interferon-alpha in a hydrophilic gel for the treatment of intravaginal warts in women: a placebo-controlled, double-blind study. | this placebo-controlled, double-blind study was aimed to evaluate the clinical efficacy, safety and tolerability of human leukocyte interferon-alpha (2 x 10(6) iu/g) incorporated in a hydrophilic gel (hydroxyethylcellulose, 1%) to cure intravaginal warts in women. preselected, subjects (n=60) who ranged between 18 and 50 years of age (mean 23.7), harbouring 275 vaginal warts (mean 4.6) with clinical, histopathological and polymerase chain reaction (pcr) confirmed diagnosis of human papillomaviru ... | 1998 | 9874127 |
| histologic and immunologic associations of an hpv16 variant in losil smears. | human papillomavirus type 16 variants have been described and may have different biologic activities: this has implications for the design of hpv vaccines. | 1999 | 9889030 |
| two polymorphic variants of wild-type p53 differ biochemically and biologically. | the wild-type p53 protein exhibits a common polymorphism at amino acid 72, resulting in either a proline residue (p53pro) or an arginine residue (p53arg) at this position. despite the difference that this change makes in the primary structure of the protein resulting in a difference in migration during sodium dodecyl sulfate-polyacrylamide gel electrophoresis, no differences in the biochemical or biological characteristics of these wild-type p53 variants have been reported. we have recently show ... | 1999 | 9891044 |
| the angelman syndrome-associated protein, e6-ap, is a coactivator for the nuclear hormone receptor superfamily. | in this study, we found that the e6-associated protein (e6-ap/ube3a) directly interacts with and coactivates the transcriptional activity of the human progesterone receptor (pr) in a hormone-dependent manner. e6-ap also coactivates the hormone-dependent transcriptional activities of the other members of the nuclear hormone receptor superfamily. previously, it was shown that e6-ap serves the role of a ubiquitin-protein ligase (e3) in the presence of the e6 protein from human papillomavirus types ... | 1999 | 9891052 |
| human papilloma virus (hpv) type 16 and 18 detected in head and neck squamous cell carcinoma. | recently the hpv genome has been detected in 75-80% of uterine cervical squamous cell carcinomas. high-risk hpv 16,18,31,33, and 45 are frequently associated with invasive carcinoma of the oral cavity, oropharynx, larynx, and nasal cavity. in this study we investigated the association of hpv16 and 18 in head and neck squamous cell carcinomas (hnscc) using pcr-based methods. | 1998 | 9891554 |
| toward a human papillomavirus vaccine. | much progress has been made over the past 10 years with regard to development of a vaccine active against hpv. successful protection has been achieved in animal models using species-specific papillomaviruses; however, hpv diversity may delay the development of successful hpv vaccines, especially those designed as therapeutic vaccines for the treatment of hpv-induced carcinoma and high-grade dysplasia of the cervix. difficulties arise with regard to assessment of efficacy of potential vaccines. t ... | 1998 | 9891690 |
| microsatellite instability in cervical intraepithelial neoplasia. | we studied the incidence of microsatellite instability (mi) in lesions defined as cervical intraepithelial neoplasia (cin). the human papillomavirus (hpv) status of the tissues was also determined. dna from tissue samples and autologous lymphocytes were studied for five loci located within or adjacent to the dna mismatch repair genes. replicate errors were detected in 7 out of 47 (14.8%) samples of cervical tissue from 24 women. our results indicate that the defect in dna repair-associated genes ... | 1998 | 9894776 |
| differential expression of immunobiological mediators by immortalized human cervical and vaginal epithelial cells. | we have recently generated human papillomavirus (hpv) 16/e6e7 immortalized epithelial cell lines from the human vagina, ectocervix, and endocervix to use in studies on the role of these cells in reproduction and immune defense. the cell lines maintain the differentiation characteristics of their tissues of origin: the endocervical cell line expresses characteristics of simple columnar epithelium, whereas the ectocervical and vaginal cell lines express characteristics of stratified squamous nonke ... | 1999 | 9916021 |
| relationship between human papillomavirus type 16 in the cervix and intraepithelial neoplasia. | to evaluate a temporal relationship between the presence of cervical human papilloma virus (hpv) type 16 and the risk of developing cervical intraepithelial neoplasia (cin). | 1999 | 9916955 |
| [current epidemiology of vulvar cancer]. | cancer of the vulva is a rare disease accounting for only 3 to 5% of all gynaecologic cancers. the incidence rates of this cancer vary depending upon the country considered, the lowest rates being reported for asian and african populations. an increased incidence of in situ carcinomas of the vulva has been noted recently among young women. in this population, the risk factors are: a young age at first sexual intercourse, multiple sexual partners, a low socio-cultural level, previous infection by ... | 1998 | 9923114 |
| randomised double blind trial of emla for the control of pain related to cryotherapy in the treatment of genital hpv lesions. | to evaluate the efficacy of emla (eutectic mixture of local anaesthetic) for the control of pain related to cryotherapy for the treatment of human papilloma virus (hpv) in the outpatient setting. | 1998 | 9924468 |
| laser conization of cervical intraepithelial neoplasia grade 3: free resection margins indicative of lesion-free survival. | various grades of cervical intraepithelial neoplasia may occur following laser conization for grade 3 lesions. the aim of this study was to assess lesion-free survival after laser conization in cases with/without free resection margins, and to test whether detection of human papillomavirus infection and/or p53 expression in the cone lesion were useful predictors of lesion-free survival. | 1999 | 9926893 |
| photodynamic therapy sensitivity is not altered in human tumor cells after abrogation of p53 function. | photodynamic therapy (pdt) is an effective local cancer treatment that induces cytotoxicity through the intracellular generation of reactive oxygen species. the current study investigated whether abrogation of wild-type p53 expression modified the sensitivity of tumor cells to pdt-mediated oxidative stress. in these experiments, human colon (ls513) and breast (mcf-7) carcinoma cells exhibiting a wild-type p53 phenotype were directly compared to ls513 and mcf-7 cells with abrogated p53 function i ... | 1999 | 9927042 |
| potentiation of e7 antisense rna-induced antitumor immunity by co-delivery of il-12 gene in hpv16 dna-positive mouse tumor. | down-regulation of oncogene expression by antisense-based gene therapy has been extensively studied, and in some cases, therapeutic effects have been demonstrated. we have previously shown that down-regulation of hpv16 e6 and e7 gene expression inhibited hpv dna-positive c3 mouse tumor growth. although not all of the tumor cells were transfected by pu6e7as plasmid, complete tumor regression was achieved if the tumor size was small at the start of therapy in a syngeneic host. this suggests that s ... | 1998 | 9930299 |
| a survey of seroprevalence of human papillomavirus types 16, 18 and 33 among children. | the importance and natural history of hpv infections in childhood is incompletely understood. we performed a survey for presence of serum antibodies to hpv capsids among 1031 children aged 0 to 13 years, resident in stockholm, sweden. the hpv seroprevalence among these children was 3.0% for hpv16, 0.6% for hpv18 and 2.7% for hpv33. by comparison, among simultaneously analyzed positive control panels comprising women with cin or healthy women with type-specific cervical hpv dna, seroprevalence of ... | 1999 | 9935145 |
| hpv 16 antibody prevalence in jamaica and the united states reflects differences in cervical cancer rates. | human papillomavirus (hpv) is widely accepted as the primary etiologic agent in the development of cervical cancer. dna of a particular hpv type, hpv 16, is found in about half of tumors tested. inconsistent with this causal relationship, however, population-based studies of hpv dna prevalence have often failed to find high rates of anogenital hpv infection in countries with high cervical cancer rates. to examine this issue, we used serology to compare hpv 16 exposure in healthy volunteer blood ... | 1999 | 9935171 |
| the chromatin structure of the long control region of human papillomavirus type 16 represses viral oncoprotein expression. | the long control region (lcr) of human papillomavirus type 16 (hpv-16) has a size of 850 bp (about 12% of the viral genome) and regulates transcription and replication of the viral dna. the 5' segment of the lcr contains transcription termination signals and a nuclear matrix attachment region, the central segment contains an epithelial cell-specific enhancer, and the 3' segment contains the replication origin and the e6 promoter. here we report observations on the chromatin organization of this ... | 1999 | 9971771 |
| detection and quantitation of human papillomavirus by using the fluorescent 5' exonuclease assay. | a method for the detection and quantitation of oncogenic human papillomavirus (hpv) was developed by using the fluorescent 5' exonuclease assay. the method is based on the amplification of a 180-bp fragment from the 3' part of the e1 open reading frame in a single pcr with type-specific probes for hpv types 16, 18, 31, 33, and 35. the probes can be used separately or in combinations of up to three probes per assay. quantitation over a range of 10(1) to 10(6) initial hpv copies was possible by us ... | 1999 | 9986801 |
| differential gene expression in neoplastic and human papillomavirus-immortalized oral keratinocytes. | we have previously demonstrated that normal human oral keratinocytes immortalized by transfection with human papillomavirus type-16 dna became tumorigenic after exposure to a chemical carcinogen. in an effort to detect differentially regulated genes associated with this transition from the immortal to the malignant phenotype, we employed representational differences analysis (a pcr-coupled subtractive hybridization technique). after analysing 50 colonies, 12 putative messages were identified. no ... | 1999 | 9989835 |
| detection of human papillomavirus types in cervical adenocarcinoma by the polymerase chain reaction. | to determine the human papillomavirus (hpv) types in cervical adenocarcinoma of patients from taiwan. | 1998 | 9989896 |
| modulation of type m2 pyruvate kinase activity by the human papillomavirus type 16 e7 oncoprotein. | we report here that the e7 oncoprotein encoded by the oncogenic human papillomavirus (hpv) type 16 binds to the glycolytic enzyme type m2 pyruvate kinase (m2-pk). m2-pk occurs in a tetrameric form with a high affinity to its substrate phosphoenolpyruvate and a dimeric form with a low affinity to phosphoenolpyruvate, and the transition between both conformations regulates the glycolytic flux in tumor cells. the glycolytic intermediate fructose 1, 6-bisphosphate induces the reassociation of the di ... | 1999 | 9990017 |
| heterogeneity of human papillomavirus dna in a patient with bowenoid papulosis that progressed to squamous cell carcinoma. | bowenoid papulosis (bp) of the genitalia, characterized by the histological findings of a squamous cell carcinoma, follows a largely benign clinical course. the detection of oncogenic human papilloma viruses (hpv) from bp points to an aetiological role of these viral infections. a 47-year-old man with multiple genital skin lesions was seen over a 10-year period with the diagnosis of bp. recently, he attended again with a recurrent genital tumour that was diagnosed as squamous cell carcinoma. his ... | 1998 | 9990379 |
| prediction of recurrent and residual cervical dysplasia by human papillomavirus detection among patients with abnormal cytology. | to determine the discriminative capacity of human papillomavirus (hpv) dna testing for recurrent and residual cervical dysplasia, 43 patients with abnormal cytology after treatment for cervical dysplasia were tested for the presence of hpv dna by pcr. an endocervical curettage was performed in all patients for histological examination. sixteen of the 43 patients showed moderate or severe dysplasia. the hpv test was positive in all 16 patients with recurrent or residual dysplasia and negative in ... | 1999 | 10021301 |
| combination therapy with podophyllin and vidarabine for human papillomavirus positive cervical intraepithelial neoplasia. | our aim was to establish an effective non-surgical treatment for cervical intraepithelial neoplasia (cin) through inactivation of human papillomavirus (hpv), the major etiological agent for this disease. we show that vidarabine, a dna polymerase inhibitor, suppressed growth and hpv gene expression in human cervical keratinocytes immortalized by hpv or in cervical cancer cell lines. expression of hpv-16 e6 and e7 proteins in normal cervical keratinocytes sensitized cells to apoptosis in the prese ... | 1999 | 10022988 |
| evaluation of human papillomavirus-consensus primers for hpv detection by the polymerase chain reaction. | cervical cancer is one of the most frequently found cancers in women and appears to have a viral aetiology. substantial evidence points to the human papillomaviruses (hpv) as the infectious agents and there is considerable interest in identifying and accurately typing the viruses. since hpvs now comprise more than 100 different hpv types, the polymerase chain reaction (pcr) has been the preferred methodology for virus identification and typing on isolated dna. in that context, five commonly empl ... | 1999 | 10024428 |
| a possible involvement of aberrant expression of the fhit gene in the carcinogenesis of squamous cell carcinoma of the uterine cervix. | to investigate involvement of an aberrant expression of the fhit (fragile histidine triad) gene in the process of carcinogenesis and progression in cervical carcinoma, we examined its expression by the reverse transcriptase polymerase chain reaction (rt-pcr) and cdna sequence method in 32 cervical invasive carcinomas (25 squamous cell carcinomas and seven adeno- or adenosquamous carcinomas) and 18 of its precursor lesions [four low-grade and 14 high-grade cervical intraepithelial neoplasias (cin ... | 1999 | 10027335 |
| cervicovaginal human papillomavirus infection in human immunodeficiency virus-1 (hiv)-positive and high-risk hiv-negative women. | human papillomavirus (hpv) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected with human immunodeficiency virus-1 (hiv). we characterized hpv infection in a large cohort of hiv-positive and hiv-negative women participating in the women's interagency hiv study to determine the prevalence of and risk factors for cervicovaginal hpv infection in hiv-positive women. | 1999 | 10037100 |
| the psychosexual impact of human papillomavirus cervical infections. | occult human papillomavirus (hpv) infection, present in approximately 20% of women in the united states, is usually sexually transmitted, associated with substantial health risks, and unpredictable in its resolution. the potential for adverse psychosexual alterations due to hpv infection in women considered at low risk for bacterial sexually transmitted diseases is substantial, but data is lacking. | 1999 | 10037541 |
| two posttranscriptional pathways that regulate p21(cip1/waf1/sdi1) are identified by hpv16-e6 interaction and correlate with life span and cellular senescence. | the p21((cip1/waf1/sdi1)) protein is a cyclin-dependent kinase inhibitor that is induced in normal human fibroblasts (nhf) following dna damage, following serum stimulation, and at cellular senescence. expression of the human papilloma virus 16 e6 oncoprotein in nhf cells results in the loss of the p21 protein, independent of mrna level under most conditions. the p21 protein levels in nhf-e6 cells remained low following dna damage or serum stimulation even though mrna levels increased. in contra ... | 1999 | 10047459 |