Publications

[genomic characteristics of 2 strains of influenza a(h9n2)virus isolated from human infection cases in anhui province].	to understand genomic characteristics of 2 strains of influenza a(h9n2)virus isolated from human infection cases in anhui province in 2015.	2016	27188368
histopathologic characterization and shedding dynamics of guineafowl (numida meleagris) intravenously infected with a h6n2 low pathogenicity avian influenza virus.	guineafowl of different ages were inoculated intravenously with a h6n2 wild waterfowl-origin low pathogenicity avian influenza virus (lpaiv). no clinical disease was observed. the infected birds had atrophy of the spleen, thymus, and cloacal bursa when compared with the noninfected control groups. the central and peripheral lymphoid tissues presented either lymphoproliferative or degenerative lesions that increased in intensity from 14 to 21 days postinoculation (dpi). lymphoid depletion was pre ...	2016	27309068
evaluation of different chemical adjuvants on an avian influenza h6 dna vaccine in chickens.	this study assessed the ability of three adjuvants (aluminium hydroxide, essai (microparticle) and phema (nanoparticle)) to enhance the immune response of chickens to an h6n2 avian influenza dna vaccine. no haemagglutination inhibition antibody was detected following two intramuscular immunizations with the adjuvanted and non-adjuvanted pcag-hak vaccine, which has previously been shown to induce moderate h6 haemagglutinin antibody response in spf chickens. following virus challenge, neither the ...	2016	27314157
molecular characterization of h6 subtype influenza viruses in southern china from 2009 to 2011.	h6 avian influenza viruses (aivs), which are prevalent in domestic and wild birds in eurasian countries, have been isolated from pigs, a dog and a human. routine virological surveillance at live poultry markets or poultry farms was conducted in southern china from 2009 to 2011. this study investigated the genetic and antigenic characteristics, analyzed the receptor-binding properties and evaluated the kinetics of infectivity of the aivs in a549, mdck and pk15 cells. a total of 14 h6n6 and 2 h6n2 ...	2016	27436363
evolutionary consequences of a decade of vaccination against subtype h6n2 influenza.	the evolutionary dynamics of chicken-origin h6n2 viruses isolated in south africa between 2002 and 2013 were investigated. sub-lineages i and ii continued to co-circulate under vaccination pressure, but sub-lineage i, from which the inactivated vaccine was derived, displayed a markedly higher mutation rate and a three-fold increase in the emergence of potential antigenic sites on the globular head of ha compared to sub-lineage ii. immunological pressure culminated in a critical phenotypic change ...	2016	27619928
immunization with live nonpathogenic h5n3 duck influenza virus protects chickens against highly pathogenic h5n1 virus.	development of an effective, broadly-active and safe vaccine for protection of poultry from h5n1 highly pathogenic avian influenza viruses (hpaivs) remains an important practical goal. in this study we used a low pathogenic wild aquatic bird virus isolate а/duck/moscow/4182/2010 (h5n3) (dk/4182) as a live candidate vaccine. we compared this virus with four live 1:7 reassortant anti-h5n1 candidate vaccine viruses with modified hemagglutinin from either a/vietnam/1203/04 (h5n1) or a/kurgan/3/05 (h ...	2017	27640442
radix isatidis polysaccharides inhibit influenza a virus and influenza a virus-induced inflammation via suppression of host tlr3 signaling in vitro.	influenza remains one of the major epidemic diseases worldwide, and rapid virus replication and collateral lung tissue damage caused by excessive pro-inflammatory host immune cell responses lead to high mortality rates. thus, novel therapeutic agents that control influenza a virus (iav) propagation and attenuate excessive pro-inflammatory responses are needed. polysaccharide extract from radix isatidis, a traditional chinese herbal medicine, exerted potent anti-iav activity against human seasona ...	2017	28085062
persistence of highly pathogenic and low pathogenic avian influenza viruses in footbaths and poultry manure.	a questionnaire was designed in order to gather information about bedding material and footbath preparation and maintenance in different productive units across the state of california.this information was used to plan two experiments. in the first experiment, we tested the effectiveness of footbaths in inactivating highly pathogenic (hp) and low pathogenic (lp) avian influenza viruses (aivs) on rubber boots. surprisingly, quaternary ammonia- and quaternary ammonia + glutaraldehyde-based footbat ...	2017	28301246
antiviral activity of formyl peptide receptor 2 antagonists against influenza viruses.	influenza viruses are one of the most important respiratory pathogens worldwide, causing both epidemic and pandemic infections. the aim of the study was to evaluate the effect of fpr2 antagonists pbp10 and boc2 on influenza virus replication. we determined that these molecules exhibit antiviral effects against influenza a (h1n1, h3n2, h6n2) and b viruses. fpr2 antagonists used in combination with oseltamivir showed additive antiviral effects. mechanistically, the antiviral effect of pbp10 and bo ...	2017	28483551
transmission of h6n2 wild bird-origin influenza a virus among multiple bird species in a stacked-cage setting.	live bird markets are common in certain regions of the u.s. and in other regions of the world. we experimentally tested the ability of a wild bird influenza a virus to transmit from index animals to naïve animals at varying animal densities in stacked cages in a simulated live bird market. two and six mallards, five and twelve quail, and six and nine pheasants were used in the low-density and high-density stacks of cages, respectively. transmission did not occur in the high-density stack of cage ...	2017	28508987
competition between influenza a virus subtypes through heterosubtypic immunity modulates re-infection and antibody dynamics in the mallard duck.	our overall hypothesis is that host population immunity directed at multiple antigens will influence the prevalence, diversity and evolution of influenza a virus (iav) in avian populations where the vast subtype diversity is maintained. to investigate how initial infection influences the outcome of later infections with homologous or heterologous iav subtypes and how viruses interact through host immune responses, we carried out experimental infections in mallard ducks (anas platyrhynchos). mall ...	2017	28640898
genetic characterization of low-pathogenic avian influenza viruses isolated on the izumi plain in japan: possible association of dynamic movements of wild birds with aiv evolution.	the izumi plain in kagoshima prefecture, japan, is an overwintering site of endangered cranes (hooded cranes and white-naped cranes) and of many other migratory birds (including wild ducks) that are considered carriers of avian influenza viruses (aivs). to assess the risks of a highly pathogenic avian influenza outbreak in the crane populations, we tested various environmental samples for aivs in this area. in the 2014-2015 winter season, we isolated one aiv of the h6n2 subtype from the cranes' ...	2018	29299682
emergence of novel reassortant h6n2 avian influenza viruses in ducks in india.	the recent reports of human infection due to h6 subtype avian influenza viruses (aiv), which are prevalent in terrestrial poultry, indicate evolution of the virus to a possible pandemic strain. here, we report antigenic and genetic characterization of two h6n2 viruses isolated from apparently healthy domestic ducks in kerala and assam, india during 2014 and 2015, respectively. hemagglutination inhibition assay revealed antigenic divergence between the two isolates, which was corroborated by amin ...	2018	29530659