Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| water soluble sulfated-fucans with immune-enhancing properties from ecklonia cava. | water-soluble sulfated fucans isolated from ecklonia cava were fractionated using an anion-exchange chromatography to investigate their molecular characteristics and immunomodulating activities. the crude fucoidan extract and purified fractions (ef1, ef2, and ef3) consisted mostly of different ratios of neutral sugars, proteins, sulfates, uronic acids, and their monosaccharide compositions were also significantly different. the backbone of the most immunoenhancing fraction, ef2, was mainly linke ... | 2014 | 24661888 |
| cytoprotective effect of eckol against oxidative stress-induced mitochondrial dysfunction: involvement of the foxo3a/ampk pathway. | this study investigated the cytoprotective effect of ecklonia cava-derived eckol against h2o2-induced mitochondrial dysfunction in chang liver cells. while h2o2 augmented levels of mitochondrial reactive oxygen species (ros), eckol decreased it. eckol also attenuated high intracellular ca(2+) levels stimulated by h2o2 and recovered h2o2-diminished atp levels and succinate dehydrogenase activity. eckol time-dependently increased the expression of manganese superoxide dismutase (mn sod), a mitocho ... | 2014 | 24700636 |
| preparative isolation and purification of phlorotannins from ecklonia cava using centrifugal partition chromatography by one-step. | various bioactive phlorotannins of ecklonia cava (e.g., dieckol, eckol, 6,6-bieckol, phloroglucinol, phloroeckol, and phlorofucofuroeckol-a) are reported. however, their isolation and purification are not easy. centrifugal partition chromatography (cpc) can be used to efficiently purify the various bioactive-compounds efficiently from e. cava. phlorotannins are successfully isolated from the ethyl acetate (etoac) fraction of e. cava by cpc with a two-phase solvent system comprising n-hexane:etoa ... | 2014 | 24731366 |
| suppression of nf-κb by dieckol extracted from ecklonia cava negatively regulates lps induction of inducible nitric oxide synthase gene. | dieckol, extracted from brown algae, ecklonia cava, is suggested to elicit anti-inflammatory or anti-tumorigenic activities. however, dieckol-mediated regulatory mechanism for inflammatory response still remains elusive. here, we show that dieckol suppressed lipopolysaccharide (lps)-induced inducible nitric oxide synthase (inos) expression in mouse leukemic macrophage raw264.7 cells. also, dieckol decreased lps-induced both nitric oxide (no) production and inos promoter-driven transcriptional ac ... | 2014 | 24744158 |
| molecular characteristics and anti-inflammatory activity of the fucoidan extracted from ecklonia cava. | enzymatic extraction has been successfully used for extracting numerous biologically active compounds from a wide variety of seaweeds. in this study, we found that enzymatic extraction of the fucoidan from ecklonia cava may be more advantageous than water extraction. therefore, we studied the e. cava fucoidans extracted by the enzymatic extraction technique and used ion-exchange chromatography to determine their molecular characteristics and anti-inflammatory activities. the crude and fractionat ... | 2012 | 24750764 |
| electrospun pcl/phlorotannin nanofibres for tissue engineering: physical properties and cellular activities. | micro/nanofibrous substrates have been widely used for tissue regeneration because of their similarities to extracellular matrix components and their high surface area, which facilitates attachment and proliferation of cells. phlorotannin, the main component of the brown alga ecklonia cava, contains various growth factors that promote the regeneration of various tissues, including bone, by stimulating alkaline phosphatase (alp) activity and inducing calcium deposition. despite the benefits of ph ... | 2012 | 24751081 |
| antioxidant marine algae phlorotannins and radioprotection: a review of experimental evidence. | radiation has been widely used for cancer therapy in human medicine. however, the side effects of radiation are problematic and can limit its application. radiation generates reactive oxygen species, leading to cell death via multiple signaling pathways. the blocking of certain signaling cascades using antioxidants represents a compensatory therapy of radiation-induced tissue injury. although synthetic chemicals have been investigated in recent decades, anti-oxidants from natural resources have ... | 2014 | 24751171 |
| enrichment and purification of marine polyphenol phlorotannins using macroporous adsorption resins. | phlorotannins are one of the most important bioactive polyphenols; however, their purification using chromatographic methods has not been explored. here, we studied purification of phlorotannins from the crude phlorotannin extract (cphe) of the brown seaweed ecklonia cava using macroporous adsorption resins. for purification of phlorotannins, four resins (hp-20, sp-850, xad-7hp, and xad-2) were screened. among them, hp-20 resin showed the highest adsorption and desorption capacities. in static a ... | 2014 | 24874368 |
| the edible brown seaweed ecklonia cava reduces hypersensitivity in postoperative and neuropathic pain models in rats. | the current study was designed to investigate whether edible brown seaweed ecklonia cava extracts exhibits analgesic effects in plantar incision and spared nerve injury (sni) rats. to evaluate pain-related behavior, we performed the mechanical withdrawal threshold (mwt) and thermal hypersensitivity tests measured by von frey filaments and a hot/cold plate analgesia meter. pain-related behavior was also determined through analysis of ultrasonic vocalization. the results of experiments showed mwt ... | 2014 | 24918539 |
| comparison of ecklonia cava, ecklonia stolonifera and eisenia bicyclis for phlorotannin extraction. | phlorotannins are polyphenols of marine algae, particularly brown seaweed, having multiple biological activities. a reverse phase-high performance liquid chromatography method was developed for rapid and routine quantification of two major phlorotannins, dieckol and phlorofucofuroeckol-a (pfe-a), from boiling water- and organic solvent-extracts of brown seaweeds ecklonia cava, e. stolonifera and eisenia bicyclis. the regression equations for dieckol and pfe-a were as follows: the concentration ( ... | 2014 | 25004758 |
| 6,6'-bieckol isolated from ecklonia cava protects oxidative stress through inhibiting expression of ros and proinflammatory enzymes in high-glucose-induced human umbilical vein endothelial cells. | hyperglycemia-induced oxidative stress accelerates endothelial cell dysfunctions, which cause various complications of diabetes. the protective effects of 6,6'-bieckol (bek), one of phlorotannin compound purified from ecklonia cava against high-glucose-induced oxidative stress was investigated using human umbilical vein endothelial cells (huvecs), which is susceptible to oxidative stress. high glucose (30 mm) treatment induced huvecs' cell death, but bek, at concentration 10 or 50 μg/ml, signifi ... | 2014 | 25086922 |
| fucodiphlorethol g purified from ecklonia cava suppresses ultraviolet b radiation-induced oxidative stress and cellular damage. | fucodiphlorethol g (6'-[2,4-dihydroxy-6-(2,4,6-trihydroxyphenoxy)phenoxy]biphenyl-2,2',4,4',6-pentol) is a compound purified from ecklonia cava, a brown alga that is widely distributed offshore of jeju island. this study investigated the protective effects of fucodiphlorethol g against oxidative damage-mediated apoptosis induced by ultraviolet b (uvb) irradiation. fucodiphlorethol g attenuated the generation of 2, 2-diphenyl-1-picrylhydrazyl radicals and intracellular reactive oxygen species in ... | 2014 | 25143808 |
| antimetastatic activity of polyphenol-rich extract of ecklonia cava through the inhibition of the akt pathway in a549 human lung cancer cells. | an ethyl acetate extract (ece) of a brown alga, ecklonia cava, was examined for its anti-metastatic effect, using a549 human lung carcinoma cells. ece treatment significantly suppressed the migration and invasion of a549 cells in a concentration-dependent manner. it also strongly down-regulated the matrix metalloproteinase (mmp)-2 activity of the cancer cells by gelatin zymography assay. for elucidating its mechanism of action in cancer cell metastasis, ece was further investigated for various c ... | 2011 | 25214119 |
| dieckol, isolated from the edible brown algae ecklonia cava, induces apoptosis of ovarian cancer cells and inhibits tumor xenograft growth. | ecklonia cava is an abundant brown alga and has been reported to possess various bioactive compounds having anti-inflammatory effect. however, the anticancer effects of dieckol, a major active compound in e. cava, are poorly understood. in the present study, we investigated the anti-tumor activity of dieckol and its molecular mechanism in ovarian cancer cells and in a xenograft mouse model . | 2015 | 25216701 |
| anti-hiv-1 activity of phlorotannin derivative 8,4‴-dieckol from korean brown alga ecklonia cava. | 8,4‴-dieckol is a natural product which has been isolated from brown alga, ecklonia cava. this polyphenolic compound is a phlorotannin derivative with a broad range of bioactivities. its inhibitory activity on human immunodeficiency virus type-1 (hiv-1) was tested and the results indicated that 8,4‴-dieckol inhibited hiv-1 induced syncytia formation, lytic effects, and viral p24 antigen production at noncytotoxic concentrations. furthermore, it was found that 8,4‴-dieckol selectively inhibited t ... | 2014 | 25229850 |
| 8,8'-bieckol, isolated from edible brown algae, exerts its anti-inflammatory effects through inhibition of nf-κb signaling and ros production in lps-stimulated macrophages. | ecklonia cava (e. cava) is an abundant brown alga that contains high levels of phlorotannins, which are unique marine polyphenolic compounds. it has been suggested that e. cava phlorotannins exert anti-inflammatory effects. however, the anti-inflammatory effects and underlying molecular mechanism exerted by 8,8'-bieckol isolated from e. cava have not been reported. thus, in this study, we examined the anti-inflammatory effects of 8,8'-bieckol on lipopolysaccharide (lps)-stimulated primary macrop ... | 2014 | 25261704 |
| effect of baechu kimchi added ecklonia cava extracts on high glucose-induced oxidative stress in human umbilical vein endothelial cells. | endothelial cell dysfunction is considered to be a major cause of vascular complications in diabetes. in the present study, we investigated the protective effect of a baechu kimchi added ecklonia cava extract (bke) against high glucose induced oxidative damage in human umbilical vein endothelial cells (huvecs). treatment with a high concentration of glucose (30 mm) induced cytotoxicity, whereas treatment with bke protected huvecs from high glucose induced damage; by restoring cell viability. in ... | 2014 | 25320714 |
| triphlorethol-a from ecklonia cava up-regulates the oxidant sensitive 8-oxoguanine dna glycosylase 1. | this study investigated the protective mechanisms of triphlorethol-a, isolated from ecklonia cava, against oxidative stress-induced dna base damage, especially 8-oxoguanine (8-oxog), in chinese hamster lung fibroblast v79-4 cells. 8-oxoguanine dna glycosylase-1 (ogg1) plays an important role in the removal of 8-oxog during the cellular response to dna base damage. triphlorethol-a significantly decreased the levels of 8-oxog induced by h2o2, and this correlated with increases in ogg1 mrna and ogg ... | 2014 | 25353254 |
| brown algae phlorotannins enhance the tumoricidal effect of cisplatin and ameliorate cisplatin nephrotoxicity. | the clinical application of cisplatin is limited due to its drug resistance and side effects. we investigated the effect of a phlorotannin-rich extract from the edible brown alga ecklonia cava (prec) and its major phlorotannin (dieckol) on cisplatin responsiveness and side effects. | 2015 | 25462204 |
| brown alga ecklonia cava polyphenol extract ameliorates hepatic lipogenesis, oxidative stress, and inflammation by activation of ampk and sirt1 in high-fat diet-induced obese mice. | obesity is considered to be a metaflammatory condition. ecklonia cava, brown algae rich in polyphenols, has shown strong antioxidant activity in vitro. this study investigated the effect of e. cava polyphenol extract (ecpe) on the regulation of fat metabolism, inflammation, and the antioxidant defense system in high fat diet-induced obese mice. after obesity was induced by a high-fat diet (hfd), the mice were administered ecpe by gavage for 5 days/12 weeks. ecpe supplementation reduced body weig ... | 2015 | 25479240 |
| dieckol as a novel anti-proliferative and anti-angiogenic agent and computational anti-angiogenic activity evaluation. | in the current study it was found that dieckol isolated from edible brown algae, ecklonia cava (ec), as potent anti-proliferative and anti-angiogenic agent. vascular endothelial growth factor (vegf) induced ea.hy926 cell proliferation was suppressed by dieckol treatment. further, it showed a significant inhibition of cell migration via inhibiting the protein and gene expression levels of matrix metalloproteinases, mmp-2 and -9. the signaling cascade underlying these responses was found as the di ... | 2015 | 25531264 |
| efficacy and safety of a dieckol-rich extract (ag-dieckol) of brown algae, ecklonia cava, in pre-diabetic individuals: a double-blind, randomized, placebo-controlled clinical trial. | the effects of 12 weeks of supplementation with a dieckol-rich extract (ag-dieckol) from brown algae, ecklonia cava, on glycemic parameters, serum biochemistry, and hematology were investigated in this study. eighty pre-diabetic male and female adults were enrolled in a randomized, double-blind, placebo-controlled trial with parallel-group design. subjects were randomly allocated into two groups designated as placebo and ag-dieckol (1500 mg per day). compared with the placebo group, the ag-dieck ... | 2015 | 25608849 |
| projecting the impacts of rising seawater temperatures on the distribution of seaweeds around japan under multiple climate change scenarios. | seaweed beds play a key role in providing essential habitats and energy to coastal areas, with enhancements in productivity and biodiversity and benefits to human societies. however, the spatial extent of seaweed beds around japan has decreased due to coastal reclamation, water quality changes, rising water temperatures, and heavy grazing by herbivores. using monthly mean sea surface temperature (sst) data from 1960 to 2099 and sst-based indices, we quantitatively evaluated the effects of warmin ... | 2015 | 25628878 |
| multifunctional activity of polyphenolic compounds associated with a potential for alzheimer's disease therapy from ecklonia cava. | five polyphenols were isolated and purified from a brown alga ecklonia cava. these compounds showed diverse biological activities such as antioxidative, antiinflammatory, and enzyme inhibitory activities. this led us to investigate the potential of these compounds as alzheimer's disease drugs. all of the compounds showed moderate acetylcholinesterase inhibitory activity in a micromolar range (ic50 from 16.0 to 96.3 μm). for butyrylcholinesterase, a new target for the treatment of alzheimer's dis ... | 2015 | 25640212 |
| phlorofucofuroeckol a isolated from ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. | this study was designed to investigate whether phlorofucofuroeckol a inhibited α-glucosidase and α-amylase activities and alleviated postprandial hyperglycemia in diabetic mice. phlorofucofuroeckol a that was isolated from ecklonia cava (brown algae) demonstrated prominent inhibitory effects against α-glucosidase and α-amylase activities. the ic50 values of phlorofucofuroeckol a against α-glucosidase and α-amylase were 19.52 and 6.34μm, respectively. these inhibitory activities of phlorofucofuro ... | 2015 | 25680946 |
| first evidence that ecklonia cava-derived dieckol attenuates mcf-7 human breast carcinoma cell migration. | we investigated the effect of ecklonia cava (e. cava)-derived dieckol on movement behavior and the expression of migration-related genes in mcf-7 human breast cancer cell. phlorotannins (e.g., dieckol, 6,6'-biecko, and 2,7″-phloroglucinol-6,6'-bieckol) were purified from e. cava by using centrifugal partition chromatography. among the phlorotannins, we found that dieckol inhibited breast cancer cell the most and was selected for further study. radius™-well was used to assess cell migration, and ... | 2015 | 25830682 |
| dieckol, a major phlorotannin in ecklonia cava, suppresses lipid accumulation in the adipocytes of high-fat diet-fed zebrafish and mice: inhibition of early adipogenesis via cell-cycle arrest and ampkα activation. | dieckol is a major polyphenol of ecklonia cava. this study demonstrates a mechanistic role for dieckol in the suppression of lipid accumulation using three models. | 2015 | 25944759 |
| dieckol attenuates microglia-mediated neuronal cell death via erk, akt and nadph oxidase-mediated pathways. | excessive microglial activation and subsequent neuroinflammation lead to synaptic loss and dysfunction as well as neuronal cell death, which are involved in the pathogenesis and progression of several neurodegenerative diseases. thus, the regulation of microglial activation has been evaluated as effective therapeutic strategies. although dieckol (dek), one of the phlorotannins isolated from marine brown alga ecklonia cava, has been previously reported to inhibit microglial activation, the molecu ... | 2015 | 25954126 |
| winogradskyella eckloniae sp. nov., a marine bacterium isolated from the brown alga ecklonia cava. | a novel bacterial strain, designated ec29(t), was isolated from the brown alga ecklonia cava collected on jeju island, republic of korea. cells of strain ec29(t) were gram-stain-negative, aerobic, rod-shaped and motile by gliding. growth was observed at 10-30 °c (optimum, 20-25 °c), at ph 6.0-9.5 (optimum, ph 7.5) and in the presence of 1-5% (w/v) nacl. phylogenetic analyses based on the 16s rrna gene sequence revealed that the strain belonged to the genus winogradskyella. strain ec29(t) exhibit ... | 2015 | 25979633 |
| dieckol, a component of ecklonia cava, suppresses the production of mdc/ccl22 via down-regulating stat1 pathway in interferon-γ stimulated hacat human keratinocytes. | macrophage-derived chemokine, c-c motif chemokine 22 (mdc/ccl22), is one of the inflammatory chemokines that controls the movement of monocytes, monocyte-derived dendritic cells, and natural killer cells. serum and skin mdc/ccl22 levels are elevated in atopic dermatitis, which suggests that the chemokines produced from keratinocytes are responsible for attracting inflammatory lymphocytes to the skin. a major signaling pathway in the interferon-γ (ifn-γ)-stimulated inflammation response involves ... | 2015 | 25995822 |
| ecklonia cava polyphenol has a protective effect against ethanol-induced liver injury in a cyclic amp-dependent manner. | previously, we showed that ecklonia cava polyphenol (ecp) treatment suppressed ethanol-induced increases in hepatocyte death by scavenging intracellular reactive oxygen species (ros) and maintaining intracellular glutathione levels. here, we examined the effects of ecp on the activities of alcohol-metabolizing enzymes and their regulating mechanisms in ethanol-treated hepatocytes. isolated hepatocytes were incubated with or without 100 mm ethanol. ecp was dissolved in dimethylsulfoxide. ecp was ... | 2015 | 26096275 |
| dieckol, a phlorotannin of ecklonia cava, suppresses ige-mediated mast cell activation and passive cutaneous anaphylactic reaction. | 2015 | 26194398 | |
| phloroglucinol attenuates the cognitive deficits of the 5xfad mouse model of alzheimer's disease. | alzheimer's disease (ad) is the most common form of dementia among the elderly. neuritic plaques whose primary component is amyloid beta peptide (aβ) and neurofibrillary tangles which are composed of hyperphosphorylated tau, are known to be the neuropathological hallmarks of ad. in addition, impaired synaptic plasticity in neuronal networks is thought to be important mechanism underlying for the cognitive deficits observed in ad. although various causative factors, including excitotoxicity, mito ... | 2015 | 26284625 |
| 6,6'-bieckol protects insulinoma cells against high glucose-induced glucotoxicity by reducing oxidative stress and apoptosis. | pancreatic β cells are highly sensitive to oxidative stress, which might play an important role in β cell death in diabetes. the protective effect of 6,6'-bieckol, a phlorotannin polyphenol compound purified from ecklonia cava, against high glucose-induced glucotoxicity was investigated in rat insulinoma cells. high glucose (30 mm) treatment induced the death of rat insulinoma cells, but treatment with 10 or 50 μg/ml 6,6'-bieckol significantly inhibited the high glucose-induced glucotoxicity. fu ... | 2015 | 26343533 |
| a sulfated polysaccharide of ecklonia cava inhibits the growth of colon cancer cells by inducing apoptosis. | we investigated anticancer effects of the crude polysaccharides (cps) isolated from ecklonia cava enzymatic extracts using amg, viscozyme, protamex, and alcalase enzyme against a colon cancer cell line, ct26 cells. among them, the cp of protamex extract (pcp) contained the highest fucose and sulfated group contents and showed the highest growth inhibitory effect against ct-26 cells. in addition, pcp dose-dependently increased the formation of apoptotic body and the percentage of sub-g1 dna conte ... | 2015 | 26417363 |
| the anti-aging properties of a human placental hydrolysate combined with dieckol isolated from ecklonia cava. | in the present study, we aimed to examine the anti-aging properties of human placental hydrolysate (hpe) and dieckol (de) from ecklonia cava against free radical scavenging, muscle hypertrophy-related follistatin mrna expression, amelioration of cognition-related genes and proteins, inhibition of collagenase-regulating genes, and elastinase activity. | 2015 | 26438076 |
| evaluation of effective mmp inhibitors from eight different brown algae in human fibrosarcoma ht1080 cells. | matrix metalloproteinases (mmps) are crucial extracellular matrices degrading enzymes that have important roles in metastasis of cancer progression as well as other significant conditions such as oxidative stress and hepatic fibrosis. marine plants are on the rise for their potential to provide natural products that exhibit remarkable health benefits. in this context, brown algae species have been of much interest in the pharmaceutical field with reported instances of isolation of bioactive comp ... | 2015 | 26451351 |
| the cytoprotective effects of ethanol extract of ecklonia cava against oxidative stress are associated with upregulation of nrf2-mediated ho-1 and nqo-1 expression through activation of the mapk pathway. | the aim of the present study was to examine the cytoprotective effect of ecklonia cava against oxidative stress in c2c12 myoblasts. the ethanol extract of e. cava (eeec) prevented hydrogen peroxide (h₂o₂)-induced inhibition of the growth of c2c12 myoblasts and exhibited scavenging activity against intracellular reactive oxygen species (ros) induced by h₂o₂. eeec treatment attenuated h2o2-induced comet tail formation and phospho-histone γh2a.x expression. furthermore, eeec treatment enhanced the ... | 2016 | 26492067 |
| flavobacterium jejuensis sp. nov., isolated from marine brown alga ecklonia cava. | a bacterial strain, designated ec11(t) was isolated from brown alga ecklonia cava collected from jeju island, korea. ec11(t) was identified as a gram-negative, rod-shaped and yellow-pigmented bacterial strain. the strain ec11(t) grew over a temperature range of 10 °c to 30 °c (optimally at 25 °c), and a ph range of 6.0-10.5 (optimally at ph 7.5). phylogenetic analysis based on 16s rrna gene sequences showed that strain ec11(t) belongs to the genus flavobacterium. strain ec11(t) shared close simi ... | 2015 | 26502959 |
| dioxinodehydroeckol protects human keratinocyte cells from uvb-induced apoptosis modulated by related genes bax/bcl-2 and caspase pathway. | although ultraviolet b (uvb) has a low level of skin penetration, it readily results in epidermal sunburn of keratinocytes that are destined to apoptosis after sun expose, and leads to dna damage. dioxinodehydroeckol (dhe), a phlorotannin from ecklonia cava has been explored for its preventive activity against uvb-induced apoptosis in human keratinocyte (hacat) cells; however, the protective effects of treatment with low doses of dhe on uvb-damaged cells post-uvb exposure and their underlying me ... | 2015 | 26529485 |
| polyphenol-rich fraction of ecklonia cava improves nonalcoholic fatty liver disease in high fat diet-fed mice. | ecklonia cava (e. cava; ca) is an edible brown alga with beneficial effects in diabetes via regulation of various metabolic processes such as lipogenesis, lipolysis, inflammation, and the antioxidant defense system in liver and adipose tissue. we investigated the effect of the polyphenol-rich fraction of e. cava produced from gijang (g-ca) on nonalcoholic fatty liver disease (nafld) in high-fat diet (hfd)-fed mice. c57bl6 mice were fed a hfd for six weeks and then the hfd group was administered ... | 2015 | 26569269 |
| seapolynol extracted from ecklonia cava inhibits adipocyte differentiation in vitro and decreases fat accumulation in vivo. | seapolynol (sn) is a polyphenol mixture derived from ecklonia cava. we evaluated the effects of sn on lipid accumulation in adipocytes, zebrafish, and mice. sn effectively inhibited lipid accumulation in three experimental models by suppressing adipogenic factors. triglyceride synthetic enzymes such as diacylglycerol acyltransferase 1 (dgat1) and gpat3 were also downregulated by sn. this sn-induced inhibition of adipogenic factors was shown to be due to the regulatory effect of sn on early adipo ... | 2015 | 26690099 |
| protective effect of brown alga phlorotannins against hyper-inflammatory responses in lipopolysaccharide-induced sepsis models. | brown algae have been recognized as a food ingredient and health food supplement in japan and korea, and phlorotannins are unique marine phenol compounds produced exclusively by brown algae. sepsis is a whole-body inflammatory condition with a mortality rate of 30-40%. here, we investigated the effects of a phlorotannin-rich extract of the edible brown alga ecklonia cava against hyper-inflammatory response in lps-induced septic shock mouse model. e. cava extract significantly increased the survi ... | 2016 | 26730445 |
| enhancement of human hair growth using ecklonia cava polyphenols. | ecklonia cava is a brown alga that contains various compounds, including carotenoids, fucoidans, and phlorotannins. e. cava polyphenols (ecps) are known to increase fibroblast survival. the human dermal papilla cell (hdpc) has the properties of mesenchymal-origin fibroblasts. | 2016 | 26848214 |
| a prebiotic effect of ecklonia cava on the growth and mortality of olive flounder infected with pathogenic bacteria. | olive flounder (paralichthys olivaceus), also known as the japanese flounder in japan, is one of the most important commercial marine finfish species cultured in korea and japan. the purpose of this study was to evaluate how a species of brown algae (ecklonia cava, e. cava) affects the growth rate of olive flounder and its immune response to pathogenic bacteria. first, the experimental fish were divided into four groups: the control group was fed the diet containing only 1.0% lactobacillus plant ... | 2016 | 26921543 |
| a molecular investigation of the genus ecklonia (phaeophyceae, laminariales) with special focus on the southern hemisphere. | brown algae of the order laminariales, commonly referred to as kelps, are the largest and most productive primary producers in the coastal inshore environment. the genus ecklonia (lessoniaceae, phaeophyceae) consists of seven species with four species in the northern hemisphere and three in the southern hemisphere. it was recently transferred to the family lessoniaceae based on phylogenetic analyses of nuclear and chloroplastic markers, though the type of the genus was not included and its relat ... | 2015 | 26986519 |
| seaweed extracts as a potential tool for the attenuation of oxidative damage in obesity-related pathologies(1). | recent studies suggest that seaweed extracts are a significant source of bioactive compounds comparable to the dietary phytochemicals such as onion and tea extracts. the exploration of natural antioxidants that attenuate oxidative damage is important for developing strategies to treat obesity-related pathologies. the objective of this study was to screen the effects of seaweed extracts of 49 species on adipocyte differentiation and reactive oxygen species (ros) production during the adipogenesis ... | 2011 | 27021984 |
| effects of ecklonia cava as fucoidan-rich algae on growth performance, nutrient digestibility, intestinal morphology and caecal microflora in weanling pigs. | in the present study, role of increasing levels of ecklonia cava (seaweed) supplementation in diets was investigated on growth performance, coefficient of total tract apparent digestibility (cttad) of nutrients, serum immunoglobulins, cecal microflora and intestinal morphology of weanling pigs. | 2017 | 27165019 |
| a prebiotic role of ecklonia cava improves the mortality of edwardsiella tarda-infected zebrafish models via regulating the growth of lactic acid bacteria and pathogen bacteria. | in this study, the beneficial prebiotic roles of ecklonia cava (e. cava, ec) were evaluated on the growth of lactic acid bacteria (lab) and pathogen bacteria and the mortality of pathogen-bacteria infected zebrafish model. the result showed that the original e. cava (ec) led to the highest growth effects on three labs (lactobacillus brevis, l. brevis; lactobacillus pentosus, l. pentosus; lactobacillus plantarum; l. plantarum) and it was dose-dependent manners. also, ec, its celluclast enzymatic ... | 2016 | 27192145 |
| microrna134 mediated upregulation of jnk and downregulation of nfkb signalings are critically involved in dieckol induced antihepatic fibrosis. | though dieckol, a phlorotannin of ecklonia cava, was known to have antioxidant, anticancer, antidiabetic, and anti-inflammatory effects, the underlying antifibrotic mechanism of dieckol still remains unclear until now. thus, in the current study, the inhibitory mechanism of dieckol on liver fibrosis was elucidated mainly in hepatic stellate cells (hscs). dieckol exerted cytotoxicity in lx-2, hsc-t6, and hepg2 cells with the reduced fibrosis features of large, spread out, and flattened polygonal ... | 2016 | 27321552 |
| protective effect of a purified polyphenolic extract from ecklonia cava against noise-induced hearing loss: prevention of temporary threshold shift. | noise is one of the most common causes of hearing loss. approximately 16% of american teenagers (12-19 years) have hearing loss caused by loud noise. the implication of noise-induced hearing loss (nihl) in teenagers has received increasing attention. although temporary threshold shift (tts), a type of nihl, is a transient hearing loss, it can accelerate age-related hearing loss. reactive oxygen species are a primary cause of tts. as the polyphenols from ecklonia cava are known to have potent ant ... | 2016 | 27368468 |
| enrichment of enzymatically mineralized gellan gum hydrogels with phlorotannin-rich ecklonia cava extract seanol(®) to endow antibacterial properties and promote mineralization. | hydrogels offer several advantages as biomaterials for bone regeneration, including ease of incorporation of soluble substances such as mineralization-promoting enzymes and antibacterial agents. mineralization with calcium phosphate (cap) increases bioactivity, while antibacterial activity reduces the risk of infection. here, gellan gum (gg) hydrogels were enriched with alkaline phosphatase (alp) and/or seanol(®), a seaweed extract rich in phlorotannins (brown algae-derived polyphenols), to indu ... | 2016 | 27509486 |
| dioxinodehydroeckol enhances the differentiation of osteoblasts by regulating the expression of phospho-smad1/5/8. | lack of bone formation-related health problems are a major problem for the aging population in the modern world. as a part of the ongoing trend of developing natural substances that attenuate osteoporotic bone loss conditions, dioxinodehydroeckol (dhe) from edible brown alga ecklonia cava was tested for its effects on osteoblastogenic differentiation in mc3t3-e1 pre-osteoblasts. dhe was observed to successfully enhance osteoblast differentiation, as indicated by elevated cell proliferation, alka ... | 2016 | 27649211 |
| protective effects of dieckol on n-nitrosodiethylamine induced hepatocarcinogenesis in rats. | dieckol (dek) is a naturally occuring phlorotannins found in marine brown algae ecklonia cava which is attributed with various pharmacological properties. this study was aimed to investigate the protective role of dek on n-nitrosdiethylamine (ndea) induced rat hepatocarcinogenesis. in this investigation 0.01% ndea in drinking water for 15 weeks to induce hepatocellular carcinoma (hcc). dek was administered orally (10, 20 and 40mg/kg body weight) for 15 weeks with 0.01% ndea through drinking wate ... | 2016 | 27825803 |
| enzyme-treated ecklonia cava extract inhibits adipogenesis through the downregulation of c/ebpα in 3t3-l1 adipocytes. | in this study, we examined the inhibitory effects of enzyme- treated ecklonia cava (eec) extract on the adipogenesis of 3t3-l1 adipocytes. the components of ecklonia cava (e. cava) were first separated and purified using the digestive enzymes pectinase (rapidase® x‑press l) and cellulase (rohament® cl). we found that the eec extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-a. among the phlorotannins, dieckol was the most abundant in the eec extract at 16 mg/ ... | 2017 | 28204815 |
| a phlorotannin constituent of ecklonia cava alleviates postprandial hyperglycemia in diabetic mice. | 2,7″-phloroglucinol-6,6'-bieckol is a type of phlorotannin isolated from brown algae, ecklonia cava kjellman (phaeophyceae; laminareaceae). 2,7″-phloroglucinol-6,6'-bieckol mediates antioxidant activities. however, there has been no research on improving postprandial hyperglycaemia using 2,7″-phloroglucinol-6,6'-bieckol. | 2017 | 28219252 |
| antimicrobial, antioxidant, and anticancer activities of biosynthesized silver nanoparticles using marine algae ecklonia cava. | green synthesis of silver nanoparticles (agnps) has gained great interest as a simple and eco-friendly alternative to conventional chemical methods. in this study, agnps were synthesized by using extracts of marine algae ecklonia cava as reducing and capping agents. the formation of agnps using aqueous extract of ecklonia cava was confirmed visually by color change and their surface plasmon resonance peak at 418 nm, measured by uv-visible spectroscopy. the size, shape, and morphology of the bios ... | 2016 | 28335363 |
| enzyme-treated ecklonia cava extract inhibits adipogenesis through the downregulation of c/ebpα in 3t3-l1 adipocytes. | in this study, we examined the inhibitory effects of enzyme- treated ecklonia cava (eec) extract on the adipogenesis of 3t3-l1 adipocytes. the components of ecklonia cava (e. cava) were first separated and purified using the digestive enzymes pectinase (rapidase® x‑press l) and cellulase (rohament® cl). we found that the eec extract contained three distinct phlorotannins: eckol, dieckol and phlorofucofuroeckol-a. among the phlorotannins, dieckol was the most abundant in the eec extract at 16 mg/ ... | 2017 | 28350055 |
| the effect of phloroglucinol, a component of ecklonia cava extract, on hepatic glucose production. | phloroglucinol is a phenolic compound that is one of the major compounds in ecklonia cava (brown alga). it has many pharmacological activities, but its anti-diabetic effect is not yet fully explored. in this study, we investigated the effect of phloroglucinol on the control of blood glucose levels and the regulation of hepatic glucose production. phloroglucinol significantly improved glucose tolerance in male c57bl/6j mice fed a high fat diet (hfd) and inhibited glucose production in mouse prima ... | 2017 | 28379184 |
| modulatory efficacy of dieckol on xenobiotic-metabolizing enzymes, cell proliferation, apoptosis, invasion and angiogenesis during ndea-induced rat hepatocarcinogenesis. | dieckol (dek) is a major polyphenol of marine brown seaweed ecklonia cava which is a potential candidate for cancer therapy. however, the underlying mechanism of dek as an anticancer drug remains to be elucidated. in this study, we evaluated the molecular mechanisms involved in the chemopreventive efficacy of dek in n-nitrosodiethylamine (ndea)-induced hepatocarcinogenesis rats by analyzing markers of xenobiotic-metabolizing enzymes (xmes), apoptosis, invasion, and angiogenesis. rats administere ... | 2017 | 28397013 |