Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| the effects of powdered fertilized eggs on depression. | abstract this 12-week, double-blind, placebo-controlled study investigated the effects of fertilized egg powder (young tissue extract; yte(®)) intake on outcome measures for depression. fifty-five patients with depression were randomly assigned to receive yte, yte plus melissa officinalis, or placebo for 12 weeks. at baseline, there were no significant differences in scores on the hamilton depression rating scale (ham-d) or beck depression inventory ii (bdi-ii) among the 3 groups. at 12 weeks, t ... | 2011 | 21631360 |
| the role of phytochemicals in the treatment and prevention of dementia. | dementia pathologies such as alzheimer's disease (ad) are reaching epidemic proportions, yet they are not successfully managed by effective symptomatic treatments. only five drugs have been developed to alleviate cognitive symptoms, and more effective and safe treatments are needed for both the cognitive symptoms and behavioural and psychological symptoms of dementia (bpsd). as two of these licensed drugs (cholinesterase inhibitors [cheis]) are naturally derived (galantamine and rivastigmine), t ... | 2011 | 21639405 |
| antioxidant capacity and total phenolic contents of oregano (origanum vulgare), lavender (lavandula angustifolia) and lemon balm (melissa officinalis) from romania. | the study reported here presents a comparative screening of three medicinal plants including oregano (origanum vulgare l.), lavender (lavandula angustifolia) and lemon balm (melissa officinalis) having the same geographical origin, the southeast region of romania, and growing in the same natural conditions. the contents of total phenolics and total flavonoids for the extracts of these were determined. furthermore, the total antioxidant capacity was also evaluated. it was found that origanum vulg ... | 2011 | 21707233 |
| effect of plant extracts on alzheimer's disease: an insight into therapeutic avenues. | alzheimer's disease (ad) is a devastative neurodegenerative disorder which needs adequate studies on effective treatment options. the extracts of plants and their effect on the amelioration of ad symptoms have been extensively studied. this paper summarizes the mechanisms like acetylcholinesterase (ache) inhibition, modification of monoamines, antiamyloid aggregation effect, and antioxidant activity which are actively entailed in the process of amelioration of ad symptoms. these effects are indu ... | 2011 | 21716802 |
| Evaluation of the genotoxic and antigenotoxic potential of Melissa officinalis in mice. | Melissa officinalis (L.) (Lamiaceae), a plant known as the lemon balm, is native to the east Mediterranean region and west Asia. Also found in tropical countries, such as Brazil, where it is popularly known as "erva-cidreira" or "melissa", it is widely used in aqueous- or alcoholic-extract form in the treatment of various disorders. The aim was to investigate in vivo its antigenotoxicity and antimutagenicity, as well as its genotoxic/mutagenic potential through comet and micronucleus assaying. C ... | 2011 | 21734832 |
| Anti-proliferative Effect of Melissa officinalis on Human Colon Cancer Cell Line. | Melissa officinalis L. (Lamiaceae) is consumed as a traditional herbal tea in the Mediterranean region. The cytotoxic effect of the 50% ethanolic and aqueous extract, determined by the MTT and NR assays, was evaluated in vitro on Human Colon Cancer Cell Line (HCT-116), using Triton 10% as positive control. The 50% ethanolic extract showed significant differences after 72 h of treatment, reducing cell proliferation to values close to 40%, even the lowest dose tested (5 µg/ml). In the MTT assay, t ... | 2011 | 21964875 |
| Protective effect of Melissa officinalis aqueous extract against Mn-induced oxidative stress in chronically exposed mice. | Manganese (Mn) is an essential element for biological systems; however occupational exposure to high levels of this metal may lead to neurodegenerative disorders, resembling Parkinson's disease (PD). While its mechanisms of neurotoxicity have yet to be fully understood, oxidative stress plays a critical role. Thus, the main goal of this study was to investigate the efficacy of aqueous extract of Melissa officinalis in attenuating Mn-induced brain oxidative stress in mice. Sixteen male mice were ... | 2012 | 22020131 |
| in vitro amoebicidal activities of satureja cuneifolia and melissa officinalis on acanthamoeba castellanii cysts and trophozoites. | amoebic keratitis is difficult to treat without total efficacy in some patients because of cysts, which are less susceptible than trophozoites to the usual treatments. the aim of this study is to evaluate the in vitro amoebicidal activity of the methanolic extracts of satureja cuneifolia and melissa officinalis. in the presence of methanolic extracts (ranging from 1.0 to 32.0 mg/ml), numbers of the viable acanthamoe castellanii trophozoites and cysts were decreased during the experimental proces ... | 2011 | 22160280 |
| Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. | Botanicals are an alternative option to prescription drugs for the alleviation of symptoms due to anxiety disorders and insomnia. Melissa officinalis L. has been shown as an anti-stress and anxiolytic agent. We previously reported moderate stress improvement in mice in which Cyracos(®), a standardized Melissa officinalis L. extract, was administrated. Cyracos(®) contains phytochemicals that inhibit gamma-aminobutyric acid catabolism. This was a prospective, open-label, 15-day study to evaluate t ... | 2011 | 22207903 |
| herbal extracts and phytochemicals: plant secondary metabolites and the enhancement of human brain function. | humans consume a wide range of foods, drugs, and dietary supplements that are derived from plants and which modify the functioning of the central nervous sytem (cns). the psychoactive properties of these substances are attributable to the presence of plant secondary metabolites, chemicals that are not required for the immediate survival of the plant but which are synthesized to increase the fitness of the plant to survive by allowing it to interact with its environment, including pathogens and h ... | 2011 | 22211188 |
| melissa officinalis extract inhibits attachment of herpes simplex virus in vitro. | extracts and essential oils of medicinal plants are increasingly of interest as novel drugs for antiherpetic agents, since the herpes simplex virus (hsv) might develop resistance to commonly used antiviral drugs. | 2012 | 22377592 |
| analysis of plant galactolipids by reversed-phase high-performance liquid chromatography/mass spectrometry with accurate mass measurement. | the composition of plant membrane lipids was investigated by reversed-phase high performance liquid chromatography mass spectrometry with accurate mass measurement. the data dependent methods for the analysis of monogalactosyldiacylglycerols (mgdgs) and digalactosyldiacylglycerols (dgdgs) have been developed. the optimised chromatographic systems were based on a 2.0 mm i.d. nucleosil c18 column with methanol/water (mgdgs) or acetonitrile/methanol/water (dgdgs) gradients. the galactolipids were i ... | 2012 | 22465211 |
| exploring biodiversity in the bacterial community of the mediterranean phyllosphere and its relationship with airborne bacteria. | we studied the structure and diversity of the phyllosphere bacterial community of a mediterranean ecosystem, in summer, the most stressful season in this environment. to this aim, we selected nine dominant perennial species, namely arbutus unedo, cistus incanus, lavandula stoechas, myrtus communis, phillyrea latifolia, pistacia lentiscus, quercus coccifera (woody), calamintha nepeta, and melissa officinalis (herbaceous). we also examined the extent to which airborne bacteria resemble the epiphyt ... | 2012 | 22544345 |
| an evaluation of the inhibitory effects against rotavirus infection of edible plant extracts. | rotaviruses are the single most important cause of severe diarrhea in young children worldwide. the developments of specific, potent and accessible antiviral treatments that restrain rotavirus infection remain important to control rotavirus disease. | 2012 | 22834653 |
| [antiinflammatory potential of seven plant extracts in the ultraviolet erythema test. a randomized, placebo-controlled study]. | phytotherapeutics are widely used in medicine. the aim of this study was the evaluation of the antiinflammatory potential of seven medical plant extracts using the ultraviolet- (uv)-erythema test. | 2013 | 23337964 |
| assessment of inhibitory potential of essential oils on natural mycoflora and fusarium mycotoxins production in wheat. | in the last years essential oils from different plants were used in the prevention of fungi and mycotoxins accumulation in cereals. the most attractive aspect derived from using of essential oils as seed grains protectants is due to their non-toxicity. this study was focused on assessment the inhibitory effect of some essential oils: melissa officinalis (o1), salvia officinalis (o2), coriandrum sativum (o3), thymus vulgaris (o4) mentha piperita (o5) and cinnamomum zeylanicum (o6) against natural ... | 2013 | 23409841 |
| adverse effects of herbal medicines: an overview of systematic reviews. | this overview of systematic reviews (srs) aims to evaluate critically the evidence regarding the adverse effects of herbal medicines (hms). five electronic databases were searched to identify all relevant srs, with 50 srs of 50 different hms meeting our inclusion criteria. most had only minor weaknesses in methods. serious adverse effects were noted only for four hms: herbae pulvis standardisatus, larrea tridentate, piper methysticum and cassia senna. the most severe adverse effects were liver o ... | 2013 | 23472485 |
| plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence. | research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. however, a comprehensive review of plant-based anxiolytics has been absent to date. thus, our aim was to provide a comprehensive narrative review of plant-based medicines that have clinical and/or preclinical evidence of anxiolytic activity. we present the article in two parts. in part one, we reviewed herbal ... | 2013 | 23653088 |
| how sensitive is melissa officinalis to realistic ozone concentrations? | lemon balm (melissa officinalis, l.; lamiaceae) was exposed to realistic ozone (o3) dosages (80 ppb for 5 h), because high background levels of o3 are considered to be as harmful as episodic o3 regimes. temporal alterations of different ecophysiological, biochemical and structural parameters were investigated in order to test if this species can be considered as an o3-bioindicator regarding changes in background concentrations. at the end of ozone exposure, the plants did not exhibit any visible ... | 2014 | 24321873 |
| ftir spectroscopic evaluation of changes in the cellular biochemical composition of the phytopathogenic fungus alternaria alternata induced by extracts of some greek medicinal and aromatic plants. | in this study, the biological activity of aquatic extracts of selected greek medicinal and aromatic plants to the phytopathogenic fungus alternaria alternata was investigated. lamiaceae species (hyssopus officinalis l., melissa officinalis l., origanum dictamnus l., origanum vulgare l. and salvia officinalis l.) were found to enhance significantly the mycelium growth whereas crocus sativus appears to inhibit it slightly. m. officinalis and s. officinalis caused the highest stimulation in myceliu ... | 2014 | 24657421 |
| attachment and penetration of acyclovir-resistant herpes simplex virus are inhibited by melissa officinalis extract. | medicinal plants are increasingly of interest as novel source of drugs for antiherpetic agents, because herpes simplex virus (hsv) might develop resistance to commonly used antiviral drugs. an aqueous extract of melissa officinalis and the phenolic compounds caffeic acid, p-coumaric acid and rosmarinic acid were examined for their antiviral activity against herpes simplex virus type 1 (hsv-1) acyclovir-sensitive and clinical isolates of acyclovir-resistant strains in vitro. when drugs were added ... | 2014 | 24817544 |
| volatile compounds of lamiaceae exhibit a synergistic antibacterial activity with streptomycin. | bacterial infections cause thousands of deaths in the world every year. in most cases, infections are more serious because the patient is already weakened, and often, the bacteria are already resistant to the antibiotics used. counterparting this negative scenario, the interest in medicinal plants as an alternative to the synthetic antimicrobial drugs is blossoming worldwide. in the present work, we identified the volatile compounds of ethanol extracts of melissa officinalis, mentha sp., ocimum ... | 2014 | 25763039 |
| a review study on the effect of iranian herbal medicines on opioid withdrawal syndrome. | addiction is a chronic and recurring disease that recurrence phenomenon is the most important challenge in treatment of this disease. recent experiences have shown that synthetic drugs have undesirable side effects. recent studies on medicinal plants have shown that they might be effective in treatment of different stages of addiction with lower side effects and costs. the aim of this study was to review the effects of medicinal plants in the treatment of morphine addiction in experimental anima ... | 2015 | 25818661 |
| detection of pyrrolizidine alkaloids in german licensed herbal medicinal teas. | because of the hepatotoxic, mutagenic, and cancerogenic effects of pyrrolizidine alkaloids (pas) the german federal institute for risk assessment (bfr) recommends not to exceed a daily pa intake of 0.007 µg/kg body weight (0.42 µg/60 kg adult). in a recent study conducted by the bfr, up to 5647 µg pa/kg dried herbal material were detected in tea products marketed as food. | 2015 | 26055130 |
| melissa officinalis l. decoctions as functional beverages: a bioactive approach and chemical characterization. | lemon balm (melissa officinalis l.) is a member of the lamiaceae family with a long story of human consumption. it has been consumed for decades, directly in food and as a decoction or an infusion for its medicinal purposes. in this manuscript, a detailed chemical characterization of the decoction of this plant is described, encompassing antimicrobial, antioxidant and antitumor activities. rosmarinic acid and lithospermic acid a were the most abundant phenolic compounds. quinic acid, fructose, g ... | 2015 | 26075899 |
| toxic potentials of ten herbs commonly used for aphrodisiac effect in turkey. | sexual dysfunction is a serious problem worldwide. in turkey, herbal products are used by some people suffering from sexual dysfunction. despite their therapeutic advantages, some constituents of herbs are potentially toxic and pose health risks because they can be bought from the market without a prescription. therefore, we aimed to determine the safety of herbs possessing aphrodisiac effects, chosen on the basis of their frequency of medicinal use and commercial importance in turkey. | 2015 | 26281312 |
| chemical composition and antimicrobial activity of the essential oil from leaves of algerian melissa officinalis l. | the essential oil obtained from leaves of melissa officinalis l. (family of lamiaceae) growing in algeria, was investigated for its chemical composition and in vitro antimicrobial activity. the chemical composition was determined by hydrodistillation and analyzed by gc/ms and gc-fid. sixty-three compounds were identified in the essential oil, representing 94.10 % of the total oil and the yields were 0.34 %. the major component was geranial (44.20 %). other predominant components were neral (30.2 ... | 2014 | 26417300 |
| pp-12 efficacy of a standardized extract of matricariae chamomilla l., melissa officinalis l. and tyndallized lactobacillus acidophilus (h122) compared with lactobacillus reuteri (dsm 17938) and with simethicone for the treatment of infantile colic. | infant colic is a prevalent physiological event of healthy children under 3 months of age, which can disrupt the child's home environment. despite its benign natural history, sometimes it requires a therapeutic approach. there is limited evidence supporting the use of complementary and alternative treatments. the aim of this study was to investigate the effectiveness of a mixture of standardized extract of matricariae chamomilla l., melissa officinalis l. and tyndallized lactobacillus acidophilu ... | 2015 | 26439577 |
| hypnotic effect of coriandrum sativum, ziziphus jujuba, lavandula angustifolia and melissa officinalis extracts in mice. | the aim of the present study was to evaluate hypnotic effect of coriandrum sativum, ziziphus jujuba, lavandula angustifolia and melissa officinalis hydroalcoholic extracts in mice to select the most effective ones for a combination formula. three doses of the extracts (250, 500 and 1000 mg/kg of c. sativum and z. jujuba and 200, 400 and 800 mg/kg of l. angustifolia and m. officinalis) were orally administered to male swiss mice (20-25 g) and one hour later pentobarbital (50 mg/kg, i.p.) was inje ... | 2017 | 26779267 |
| hplc-dad phenolic profile, cytotoxic and anti-kinetoplastidae activity of melissa officinalis. | context melissa officinalis subsp. inodora bornm. (lamiaceae) has been used since ancient times in folk medicine against various diseases, but it has not been investigated against protozoa. objective to evaluate the activities of m. officinalis against leishmania braziliensis, leishmania infantum and trypanosoma cruzi as well as its cytotoxicity in fibroblast cell line. materials and methods the fresh leaves were chopped into 1 cm(2) pieces, washed and macerated with 99.9% of ethanol for 72 h at ... | 2016 | 26864563 |
| adverse effects of plant food supplements and plants consumed as food: results from the poisons centres-based plantlibra study. | plant food supplements (pfs) are products of increasing popularity and wide-spread distribution. nevertheless, information about their risks is limited. to fill this gap, a poisons centres-based study was performed as part of the eu project plantlibra. multicentre retrospective review of data from selected european and brazilian poisons centres, involving human cases of adverse effects due to plants consumed as food or as ingredients of food supplements recorded between 2006 and 2010. ten poison ... | 2016 | 26948409 |
| chestnut and lemon balm based ingredients as natural preserving agents of the nutritional profile in matured "serra da estrela" cheese. | chestnut flowers, lemon balm plants and their decoctions were incorporated into "serra da estrela" cheese, to assess their potential to preserve its nutritional properties and provide new foodstuffs. the analyses were carried out after the normal ripening period of 1month and after 6months of storage. the most abundant nutrients were proteins and fats. the most abundant minerals were ca and na, while c16:0 and c18:1 were the main fatty acids. saturated fatty acids were the most abundant, followe ... | 2016 | 26988492 |
| effect of arbuscular mycorrhizal fungi on the growth and polyphenol profile of marjoram, lemon balm, and marigold. | the aim of this study is to examine the effect of arbuscular mycorrhizal fungi (amf) colonization on biomass, polyphenol profile, and content of economically important herbs. a pot experiment was performed with marjoram, lemon balm, and marigold applying a commercially available amf mixture for inoculation. major polyphenols were identified using hplc-uv-esi-qtofms on the basis of their uv-vis and mass spectral characteristics, and selected ones were quantified. we showed that amf can provide di ... | 2016 | 27096876 |
| antiviral activity of the oseltamivir and melissa officinalis l. essential oil against avian influenza a virus (h9n2). | lemon balm derivatives are going to acquire a novelty as natural and potent remedy for treatment of viral infections since the influenza viruses are developing resistance to the current antivirals widely. oseltamivir, melissa officinalis essential oil (moeo) and their synergistic efficacy against avian influenza virus (aiv) subtype h9n2 were evaluated in vitro in mdck cells at different time exposure by using tcid50, ha, real time pcr and hi assay. the results showed that moeo could inhibit repl ... | 2016 | 27366768 |
| medicinal herbs in iranian traditional medicine for learning and memory. | a few factors such as age, stress, and emotions may lead to impaired learning, memory loss, amnesia, and dementia or threats like schizophrenia and alzheimer's disease (ad). iranian traditional medicine (itm) recommends some herbs and herbal preparations for the treatment or prevention of cns problems. | 2016 | 27516676 |
| essential oils: in vitro activity against leishmania amazonensis, cytotoxicity and chemical composition. | the current chemotherapy for cutaneous leishmaniosis (cl) has a series of drug limitations such as toxic side effects, long duration, high costs and drug resistance, which requires the development of new drugs or effective alternatives to the cl treatment. essential oils (eos) are complex mixtures of secondary metabolites from various plants. it has been shown that several eos, or their constituents, have inhibitory activity against protozoa. thus, this study aims to evaluate the biological acti ... | 2016 | 27825341 |
| medicinal herbs in iranian traditional medicine for learning and memory. | a few factors such as age, stress, and emotions may lead to impaired learning, memory loss, amnesia, and dementia or threats like schizophrenia and alzheimer's disease (ad). iranian traditional medicine (itm) recommends some herbs and herbal preparations for the treatment or prevention of cns problems. | 2016 | 27840509 |
| antioxidant and antibacterial activity of the beverage obtained by fermentation of sweetened lemon balm (melissa officinalis l.) tea with symbiotic consortium of bacteria and yeasts. | kombucha is a fermented tea beverage which is traditionally prepared by fermenting sweetened black or green tea (camellia sinensis l.) with symbiotic consortium of bacteria and yeasts (scoby). in this study, lemon balm (melissa officinalis l.) was used as the only nitrogen source for kombucha fermentation. during the seven-day fermentation process, ph value, titratable acidity (ta), total phenolic content, phenolic compounds, and antioxidant activity against hydroxyl (˙oh) and 1,1-diphenyl-2-pic ... | 2014 | 27904315 |
| biological activities of asteraceae (achillea millefolium and calendula officinalis) and lamiaceae (melissa officinalis and origanum majorana) plant extracts. | asteraceae (achillea millefolium and calendula officinalis) and lamiaceae (melissa officinalis and origanum majorana) extracts were obtained by applying two sequential extraction processes: supercritical fluid extraction with carbon dioxide, followed by ultrasonic assisted extraction using green solvents (ethanol and ethanol:water 50:50). the extracts were analyzed in terms of the total content of phenolic compounds and the content of flavonoids; the volatile oil composition of supercritical ext ... | 2017 | 28101823 |
| [investigation of the in vitro effects of melissa officinalis l., mentha x piperita l. and ocimum basilicum l. (lamiaceae) essential oils on the cysts and trophozoites of acanthamoeba castellani]. | acanthamoeba species are free living amoeba found widely all over the world. they are responsible for acanthamoeba keratitis (ak), an infection which is especially seen in contact lens users and after minor corneal traumas, that may lead blindness. at present, antifungals and antiseptics are used for the treatment of ak cases, however, some problems such as long treatment periods and the occurrence of side effects, resistance of cyst forms against drugs, emphasize the need for new drugs. there a ... | 2016 | 28124962 |
| potential benefits of phytochemicals against alzheimer's disease. | our current therapeutic drugs for alzheimer's disease are predominantly derived from the alkaloid class of plant phytochemicals. these drugs, such as galantamine and rivastigmine, attenuate the decline in the cholinergic system but, as the alkaloids occupy the most dangerous end of the phytochemical spectrum (indeed they function as feeding deterrents and poisons to other organisms within the plant itself), they are often associated with unpleasant side effects. in addition, these cholinesterase ... | 2017 | 28143625 |
| drug target identification and elucidation of natural inhibitors for bordetella petrii: an in silico study. | environmental microbes like bordetella petrii has been established as a causative agent for various infectious diseases in human. again, development of drug resistance in b. petrii challenged to combat against the infection. identification of potential drug target and proposing a novel lead compound against the pathogen has a great aid and value. in this study, bioinformatics tools and technology have been applied to suggest a potential drug target by screening the proteome information of b. pet ... | 2016 | 28154518 |
| medicinal plants targeting cardiovascular diseases in view of avicenna. | cardiovascular disease (cvd) is a spectrum of diseases involving the heart and blood vessels, and the first cause of mortality worldwide. medicinal plants have been used for thousands of years to treat cvd. in traditional persian medicine (tpm), there is a special focus on heart diseases. avicenna, a persian physician of the eleventh century compiled a book devoted to this field named "the treatise on cardiac drugs" which is a compendium of tpm knowledge on cvd. avicenna mentioned 50 cardiovascul ... | 2017 | 28215156 |
| essential oil composition and antifungal activity of melissa officinalis originating from north-est morocco, against postharvest phytopathogenic fungi in apples. | to investigate biological control methods against post-harvest phytopathogenic fungi in apples, tests on the antifungal activity of essential oil of melissa officinalis were carried out. the essential oil, obtained by hydrodistillation, was analyzed by gas chromatography coupled with mass spectrometry (gc-ms). analysis of the essential oil was able to detect 88.7% of the components. the main components are p-mentha-1,2,3-triol (13.1%), p-menth-3-en-8-ol (8.8%), pulegone (8.8%), piperitynone oxid ... | 2017 | 28389346 |