Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| studies on immunity to aujeszky's disease (pseudorabies) virus infection in pigs. | aujeszky's disease is primarily a disease of pigs caused by a herpesvirus. in pigs, the primary site of virus replication is the nasopharynx. some strains cause lesions only in the central nervous system, others cause rhinitis, pneumonia and encephalitis. colostrum from immune sows protected 3 day old piglets from experimental infection, but did not prevent the piglets excreting virus. colostral antibodies were 11-16-fold greater than the serum titres in the sows and the half life of passiveanti ... | 1975 | 165131 |
| genital herpes: treatment with methylene blue and light exposure. | fifty-six patients with genital herpes were treated by photodynamic inactivation of herpesvirus by methylene blue (36 patients), proflavine (101 or neutral red (10). the first 35 patients were randomly selected for treatment with one of the three dyes. all the others were initially treated with methylene blue. the disease was temporarily eradicated in about 70% of instances by exposure of the lesions to light plus topically applied methylene blue, neutral red or proflavine. relapses, however, we ... | 1975 | 165157 |
| specific immunity and nonspecific resistance to infection: listeria, protozoa, and viruses in mice and hamsters,. | specific immunity developed by mice against protozoan (toxoplasma gondii and besnoitia jellisoni) and bacterial (listeria monocytogenes) infections was compared with nonspecific protection conferred by prior infections. the results indicated that homologous immunity protected mice from more than 10-5 ld50 of t. gondii or b. jellisoni, but from only 10-2 ld50 of l. monocytogenes. heterospecific protection among these organisms was for 10-0.4 minus 10-1.2 ld50. in studies in hamsters specific immu ... | 1975 | 165241 |
| replication of herpesvirus saimiri in cultured lymphocytes of infected owl monkeys (aotus trivirgatus). an electron microscopic and immunofluorescent study. | the lymphocytes of five owl monkeys infected with herpesvirus saimiri (hvs) and three control monkeys were studied. lymphocytes were separated on ficoll-hypaque gradients, incubated in suspension cultures, and prepared for electron microscopic and immunofluorescent study at 24, 48, and 72 hours after the beginning of culture (ac). buffy coats of whole blood immediately after bleeding were also prepared for study. at the time of the study, four of the five infected monkeys had died of malignant l ... | 1975 | 165331 |
| etiology of nongonococcal urethritis. | chlamydia trachomatis was isolated from the urethra from 48 (42 per cent) of 113 men with non-gonococcal urethritis (ngu), four (7 per cent) of 58 without overt urethritis, and 13 (19 per cent) of 69 with gonorrhea. postgonococcal urethritis (pgu) developed in 11 of 11 men who had c. trum antibody to c. trachomatisis developed. the immunotype specificity of chlamydial antibody corresponded to the immunotype isolated. among culture-negative patients. chlamydial antibody prevalence correlated with ... | 1975 | 165407 |
| regulation of herpesvirus macromolecular synthesis: sequential transition of polypeptide synthesis requires functional viral polypeptides. | it was previously shown that virus-specific polypeptides made in hep-2 cells infected with herpes simplex 1 form three groups designated alpha, beta, and gamma whose synthesis is coordinately regulated and sequentially ordered. this report shows that one or more functional alpha polypeptides are necessary to turn on the synthesis of beta and gamma groups, and conversely, one or more polypeptides in the latter groups turn off the synthesis of alpha polypeptides. specifically, infected cells maint ... | 1975 | 165503 |
| photodynamic inactivation of herpesvirus hominins by methylene blue (38524). | methylene blue, in a concentraion of 10-5m was virostatic in the presence of light but not in the dark for 31 of 37 strains of fresh isolates of herpesvirus hominis. resistance to the dye developed during treatment. this photodynamic pattern was almost identical to that of neutral red which produced an identical effect. this was not ture for proflavine which was active in the dark in many instances. cross insensitivity between proflavine and methylene blue was not observed. | 1975 | 165528 |
| malignant transformation of hamster cells following infection with bovine herpesvirus (infectious bovine rhinotracheitis virus. | hamster embryo cells, following infection with ibr virus, showed malignant transformation. hamsters of all ages, inbred or random bred, inoculated with two of the transformed cell lines developed solid tumors. preliminary characterization of the tumors induced by one of the cell lines has indicated undifferentiated sarcomas. viral specific antigen was detected in about 5% of the transformed cells and 10% of primary tumor cells in culture. viral specific antibody was detected in the serum of ... | 1975 | 165538 |
| tumor antigens in hamsters with sarcomas associated with herpesvirus type 2. | tumor-associated antigens (tta) were demonstrated in preparations of hamster sarcomas associated with herpes simplex virus type 2, as well as in the sera of tumor-bearing hamsters. an immunoadsorption-in-gel method was employed to demonstrate and purify the taa and anti-taa. these results suggest the potential use of this technique for the demonstration of taa or of anti-taa in humans or animals with cancer. | 1975 | 165539 |
| a comparison in calves of the antigenicity of three strains of bovid herpesvirus 2. | three strains of bovid herpesvirus 2, viz. allerton, bovine mammillitis and 69/1lo were used to infect calves intradermally. twenty-eight days later the immunity of the calves was challenged by intravenous injection of a homologous or heterologous strain. challenge control calves developed a fever (greater than 40 degrees c) lasting several days and widespread skin lesions which varied with the strain. homologous challenge of the primary infection produced neither skin lesions nor febrile respon ... | 1975 | 165571 |
| early functions of the genome of herpesvirus. v. serological analysis of "immediate-early" proteins. | 1975 | 165618 | |
| recovery from encephalomyelitis caused by herpesvirus simiae. report of a case. | a 29-year-old monkey handler developed an acute encephalomyelitis with neuromuscular dysfunction that progressed to respiratory arrest on the 18th day of illness. thereafter, with supportive care, the patient's condition improved steadily. the titer of neutralizing antibodies to h simiae rose from 1:4 (eighth day of illness) to 1:512 (47th day of illness). apparently the fifth known survivor of h simiae (herpesvirus b) encephalomyelitis, this patient is also remarkable because of virtually compl ... | 1975 | 165794 |
| in vitro transformation of hamster cells by herpes simplex virus type 2 from human prostatic cancer cells. | a cell-associated herpes simplex virus type 2 found in a human prostatic carcinoma induced in vitro transformation of hamster embryo cells. the transformed cells (yw-74) have been shown to be hamster cells by karyotype analysis. their epithelial morphology and growth pattern, which are different from the parental cell, have remained stable through cell passages. the presence of herpesvirus antigens in the transformed cells was determined by specific immunofluorescence and colony inhibition tests ... | 1975 | 165889 |
| clinicopathologic characterization of herpesvirus saimiri malignant lymphoma in new zealand white rabbits. | twenty-two of 39 rabbits inoculated with herpesvirus saimiri developed malignant lymphoma and either died or were killed between 17 and 165 days after inoculation. no clinical signs were present in animals developing the disease before 46 days, but all other rabbits had a severe conjunctivitis, nasal discharge, and dyspnea resulting from a lymphocytic invasion of the ocular and nasal tissues. four rabbits developed terminal leukemia. pathologically, the disease resembled h. saimiri malignant lym ... | 1975 | 166191 |
| iodination of herpesvirus nucleic acids. | a simple method is described for the iodination of herpes simplex virus (hsv) dna. the procedure involved synthesis of 125-i-labeled 5-iodo-dctp which was subsequently used as a precursor for the in vitro repair synthesis of hsv dna. synthesis of 5-iodo-dctp and purification from oxidation and reduction reagents, buffer salts, unreacted dctp and na125-i was accomplished in a single chromatographic step. it was possible to prepare 125-i-labeled hsv dna in vitro with specific activities exceeding ... | 1975 | 166201 |
| horizontal transmission of turkey herpesvirus to chickens. 3. transmission in three different lines of chickens. | horizontal transmission of turkey herpesvirus (hvt) was studied in three separate trials using three different lines of chickens in each trial. there was no horizontal spread of hvt to contact cagemates through 8 weeks regardless of the line of donor chickens, when inoculated subcutaneously with 9.2 times 10-3 plaque-forming units (pfu) of hvt at 1 week of age. the virus spread poorly to a few cagemates from an experimental line of white leghorns (w.s.u.-v.s.), but not from a commercial line o ... | 1975 | 166362 |
| isolation of equine herpesvirus type 1 from a horse with an acute paralytic disease. | a standardbred mare became paralyzed shortly after showing signs of an upper respiratory infection. the mare was euthanized and equine herpesvirus type 1 was isolated from the brain and spinal cord. | 1975 | 166741 |
| inhibition of herpesvirus hominis replication by human interferon. | the effect of human interferon on single-cycle replication of herpesvirus hominis type 1 (hv-1) and vesicular stomatitis virus (vsv) in human foreskin fibroblast cultures (hff) was studied. after treatment of hff cultures with low concentrations (58 u) of human interferon, a variable but statistically significant inhibition of hv-1 was observed. at higher concentrations (greater than 95 u) yield reduction of hv in interferon-treated cultures approached that of vsv. preliminary data indicate that ... | 1975 | 166922 |
| effect of human leukocyte interferon on vaccinia-and herpes virus-infected cell cultures and monkey corneas. | pretreatment of human fibroblast cultures with human leukocyte interferon (hif, 1,000 iu/ml) resulted in a 24-h delay of virus replication after infection with vaccinia virus and herpes simplex virus type 1 and type 2. additional hif treatment 24 h after infection effectively lowered the maximum yield of viral infectivity. equal results were obtained in simian cells with 3,000 iu of hif per ml. the spread of two cell-bound herpesviruses, varicella zoster virus and medical lake macaque herpesviru ... | 1975 | 166924 |
| herpersvirus strigis: host spectrum and distribution in infected owls. | herpesvirus strigis, a new species of the genus herpesvirus, is a pathogen for several species of owls in the order srigiformes. natural infection has been observed in the eagle owl (bubo bubo l.), long-eared owl (asio otus l.) and snowy owl (nyctea scandiaca l.) in addition the little owl (athene noctua scopolic) and tengmalms owl (aegolius funereus l.) was experimentally infected. on the other hand the tawny owl (strix aluco l.) and barn owl (tyto albo scopoli) proved resistant to a massive ex ... | 1975 | 167204 |
| multiple herpesvirus simiae isolation from a rhesus monkey which died of cerebral infarction. | a rhesus monkey housed in the new england regional primate research center for more than 4 yr died after an illness of 19 da. clinical signs included central nervous system involvement and ulcers on the labial mucosa. microscopically, the cause of death was established as multiple cerebral infarction. lesions characteristic of herpesvirus infections were not present in the brain nor in any other tissue; however, herpesvirus simiae was isolated from oral and anal swabs as well as from tongue and ... | 1975 | 167229 |
| virus isolation and titration at 33 degrees and 37 degrees c. | various prototype viruses and original specimens were comparatively titrated in cell cultures at 33 degrees and 37 degrees c. higher titers at 37 degrees were consistently obtained with adenoviruses; for other viruses (enteroviruses, herpesvirus hominis, vaccinia virus, parainfluenza viruses) the titers were mostly identical at either temperature. original specimens and prototye strains showed the same behavior. the habit to cultivate viruses from throat swabs at 33 degrees c is unsatisfactory f ... | 1975 | 167268 |
| passive immunisation of marmoset monkeys against neoplasia induced by a herpesvirus. | 1975 | 167281 | |
| herpesvirus hominis infections in renal transplant recipients. | a longitudinal, prospective study of herpesvirus hominis (hvh, herpes simplex virus) was carried out in immunosuppressed renal allograft recipients using serologic, virologic and clinical techniques. the final study group consisted of 37 patients of which 31 were followed for at least 2 months and 26 for more than 1 year. a 4-fold rise or more in hvh complement-fixing antibody in relation to titers measured at the time of transplantation was found in 11 patients. eight of these 11 patients had c ... | 1975 | 167430 |
| the ultrastructure of disrupted herpesvirus nucleocapsids. | 1975 | 167517 | |
| exacerbation and reactivation of herpesvirus hominis infection in mice by cyclophosphamide. | cyclophosphamide has been shown to potentiate the growth of herpesvirus hominis in the skin of webster schneider mice. higher skin yields of virus were obtained, marked dissemination of virus to the brain was produced and mortality in mice was increased. serum neutralizing antibody titres were suppressed. the system may serve as a good model for the study of specific antiherpes drugs. | 1975 | 167686 |
| studies of marek's disease herpesvirus and turkey herpesvirus specific common antigen which stimulates the production of neutralizing antibodies. | an agar-gel precipitation antigen prepared from the skin (feather-ag) of chicken infected with jm strain of marek's disease herpesvirus (mdhv) and cell extracts of cultures infected with either type 2 plaque producing agent (ppa) of mdhv or turkey herpesvirus (hvt) (type 2-ag, hvt-ag) had 1 precipitation line in common. hyperimmune sera to the common antigen (common-ag) neutralized to a greater extent by homologous antiserum. absorption of hvt antiserum or hyperimmune serum to type 2 ppa with co ... | 1975 | 167687 |
| effect of immunization with attenuated mycobacterium bovis (bcg) on experimental herpetic keratitis. | mycobacterium bovis (bcg, pasteur strain) was injected intraperitoneally into guinea pigs and rabbits on the 19th and 5th days prior to the intracorneal inoculation of herpesvirus hominis. during a three-day and nine-day observation period, respectively, the bcg had no significant effect on the clinical course of the herpetic keratitis and no effect on the titer of virus present in the infected corneas. | 1975 | 167922 |
| epidemiology of herpesvirus and respiratory virus infections. part 1. serologic findings. | the majority of the population group studied had complement-fixation antibodies toward the following viruses: influenza type a, respiratory syncytial, cytomegalovirus, and epstein-barr. the herpesvirus infections (cytomegalovirus and epstein-barr virus) seemed to be prevalent. only low incidences of antibodies were found toward adenovirus, influenza type b, influenza type c, and parainfluenza type ii. a total of 70 aucte virus infections (increases of antibody titer) were diagnosed in 49 patient ... | 1975 | 168127 |
| epidemiology of herpesvirus and respiratory virus infections. part2. clinical findings. | 1975 | 168128 | |
| immunological relationship between delta herpesvirus of patas monkeys and varicells-zoster virus of humans. | the delta herpesvirus (dhv) which produced outbreaks of exanthematous disease in patas monkeys was shown to have a close immunological relationship to varicella-zoster (v-z) virus of man. immunization of rhesus monkeys with dhv or v-z virus resulted in the development of neutralizing antibodies to both viruses and also in the production of complement-fixing antibodies to v-z virus. immunoglobulin m neutralizing antibody to v-z virus was demonstrated in the serum of a rhesus monkey immunized with ... | 1975 | 168152 |
| epidemiological studies of epstein-barr herpesvirus infection in western australia. | in a study of a caucasian population in western australia the prevalence of antibodies to epstein-barr virus (ebv) was 41% in the 9- to 10-year age group, 80% in the 16 to 19-year age group and 92% in young adults. the age-specific annual seroconversion rates indicated two peaks of primary ebv infection in the population studied - one under 5 years of age and the other at adolescence. the geometric mean titre rose with age, from 23 at 5-6 years to 53 at 36-40 years. it was shown that in 73 famil ... | 1975 | 168249 |
| immunologic effects of neonatal infection with mouse thymic virus. | mouse thymic virus is a herpesvirus that causes extensive thymic necrosis when given to newborn mice. during the time of acute infection spleen cells have markedly diminished reactivity to t cell phytomitogens and to allogeneic cells and are incapable of effecting a primary in vitro response to a "t-dependent" antigen; responses to b cell mitogens and to a t-independent antigen are unimpaired. spleens from acutely infected mice have low theta antigen normal numbers of immunoglobulin-bearing cell ... | 1975 | 168265 |
| in vitro activity of silver sulfadiazine against herpesvirus hominis. | silver sulfadiazine, at a concentration of 10 mug/ml, inhibits herpesvirus hominis types 1 and 2 in vitro. the antiviral effect is directly related to concentration of the drug and duration of exposure. | 1975 | 168275 |
| effect of 2-deoxy-d-glucose on herpesvirus-induced inhibition of cellular dna synthesis. | in pseudorabies virus-infected cells host dna synthesis is turned off 4 to 5 h postinfection. in the presence of 0.5 mm 2-deoxy-d-glucose, however, synthesis of both cellular and viral dna proceeds unimpaired throughout the virus replication cycle. the uptake of radioactive thymidine into mock-infected cells is not altered in the presence of 2-deoxy-d-glucose. virus-specific protein synthesis and particle formation also proceed in medium containing the deoxy sugar, but the virus particles produc ... | 1975 | 168399 |
| primary lymphoreticuloses of the nervous system in animals. | lymphoreticular proliferative disorders occur in most species of animals including submammalian vertebrates but only occasionally affect the nervous system. primary lymphoreticular disorders of the nervous system have been recognized in chickens as a herpesvirus-induced avian neurolymphomatosis and in mammals, patricularly in the dog, as reticulum cell sarcomas originating from perivascular mesenchymal precursor cells. criteria have been discussed to distinguish neoplastic from inflammatory lymp ... | 1975 | 168723 |
| a herpesvirus-type agent associated with skin lesions of green sea turtles in aquaculture. | nine successive groups of green sea turtles (chelonia mydas) were observed in aquaculture during the posthatchling period. during the first 6 months of growth, each group underwent an epizootic of skin lesions, named gray-patch disease. two types of skin lesions are associated with gray-patch disease: papules and, more characteristically, spreading gray patches which appear 7 to 8 weeks after hatching. in both types of lesions, intranuclear inclusions are found in keratinocytes in the malpighian ... | 1975 | 168798 |
| influence of vaccination with avirulent herpesvirus on subsequent infection of chickens with virulent marek's disease herpesvirus. | vaccination of chickens with turkey herpesvirus (hvt) or attenuated marek's disease herpesvirus (amdhv) blocked infection with virulent mdhv (vmdhv) for approximately 5 weeks after contact exposure. however, there was no apparent blockage of infection when challenge virus was administered intraabdominally (ia). evidence for infection with vmdhv was based on viral isolation by in vivo assay or by detecting precipitins to "a" antigen associated with virulent virus. the hvt stimulated production of ... | 1975 | 168799 |
| regulation of herpesvirus macromolecular synthesis: evidence for multilevel regulation of herpes simplex 1 rna and protein synthesis. | 1975 | 169025 | |
| genetic and biochemical studies with herpesvirus. | 1975 | 169027 | |
| the isolation of monkey b virus (herpesvirus simiae) from the trigeminal ganglia of a healthy seropositive rhesus monkey. | 1975 | 169266 | |
| antiviral activity of adenine arabinoside and iododeoxyuridine in human fetal intestinal and tracheal organ cultures. | in vitro antiviral activities of two potentially clinically useful antiviral compounds, adenine arabinoside and iododeoxyuridine, were examined in human fetal intestinal and tracheal organ cultures infected with herpesvirus hominis (types 1 and 2) or vaccinia virus. the two compounds were similarly active against the viruses in organ culture, and minimal inhibitory concentrations could be determined by titration of organ culture fluid harvests into tissue culture or directly in the organ culture ... | 1975 | 169312 |
| immunofluorescent staining for the measurement of antibodies to herpesvirus hominis. | frozen sections of herpesvirus hominis-inoculated mouse brain provide excellent antigens for indirect immunofluorescent staining of antibodies to h. hominis in serum. indirect immunofluorescent staining is a rapid, sensitive, and reproducible method for the measurement of antibodies to h. hominis. the method can be applied to the clinical and epidemiological studies of h. hominis infections. | 1975 | 169313 |
| oncogenesis by marek's disease herpesvirus in chickens lacking expression of endogenous (gs, chick helper factor, rous-associated virus-o) and exogenous avian rna tumor viruses. | chickens free of exogenous avian leukosis virus (alv) infection, replicating endogenous alv (rous-associated virus-o), gs antigen, and chick helper factor were fully susceptible to induction of marek's disease (md) by alv-free md viruses. dual infection with rous-associated virus-2 and md virus did not significantly alter the character of the md lesions. thus exogenous alv infection was not requisite for md virus-induced oncogenesis. although participation of endogenous rna tumor virus genes in ... | 1975 | 169364 |
| mitochondrial and herpesvirus-specific deoxypyrimidine kinases. | to characterize and compare the thymidine (tdr) and deoxycytidine (cdr) kinase isozymes of uninfected and herpesvirus-infected cells: (i) the subcellular distribution of the isozymes has been studied; (ii) a specific assay for cdr kinase has been devised; (iii) the tdr kinase isozymes have been partially purified; and (iv) the purified enzymes have been analyzed by disc polyacrylamide gel electrophoresis, isoelectric focusing, and glycerol gradient centrifugation and by substrate competition and ... | 1975 | 169387 |
| augmentation of lymphocyte cytotoxicity by antibody to herpesvirus saimiri associated antigens. | sera from owl monkeys infected with herpesvirus saimiri (hvs) mediated antibody-dependent lymphocyte cytotoxicity (adlc) against virus-infected owl monkey kidney cells. peripheral blood lymphocytes from rhesus monkeys served as effector cells in this cytotoxic assay. adlc titers increased along with membrane immunofluorescence (mf) titers but among some sera, the adlc titers were much higher than expected from the mf titers, suggesting that multiple serum factors were involved in mediating adlc ... | 1975 | 169525 |
| nosocomial and maternally acquired herpesvirus hominis infections. a report of four fatal cases in neonates. | four fatal cases of neonatal herpes simplex infection occurred during a two-month period in the perinatal intensive care unit of a hospital. virus isolation or serologic studies, or both, implicated herpesvirus hominis type 2 in all four cases. three of the infants developed symptoms in the first week of life and were probably infected in utero or at delivery. the fourth infant did not develop signs of illness until age 6 weeks, an interval much longer than that expected with disease acquired at ... | 1975 | 169688 |
| neonatal risk following late gestational genital herpesvirus hominis infection. | 1975 | 169690 | |
| spontaneous herpesvirus saimiri lymphoma in owl monkeys. | three examples of spontaneous malignant lymphoma were observed in owl monkeys 23, 81, and 183 days after arrival in our laboratories. the pathological features of the disease were analogous to experimentally induced herpesvirus saimiri lymphoma. h. saimiri was recovered from 2 animals (it was not attempted from one case) and one isolate was shown to reproduce characteristic h. saimiri malignant lymphoma. each monkey originated in peru in contrast to our usual source of owl monkeys which originat ... | 1975 | 169813 |
| experiments to vaccinate marmoset monkeys against malignant lymphoma. | humoral antibodies can be induced in cotton topped (ct) marmosets with killed herpesvirus saimiri (hvs) vaccines. the serum antibodies delayed, but did not prevent, malignant lymphoma in actively and passively immunized monkeys after inoculation with 10(3.8)tcid50 of cell-free hvs. experiments are in progress to determine whether the vaccines are able to protect against smaller challenge dosages of hvs. the immunized monkeys were not resistant against transplantation of tumor cells. infection wi ... | 1975 | 169814 |
| comparisons of surface markers on herpesvirus-associated lymphoid cells of nonhuman primates and established human lymphoid cell lines. | herpesvirus saimiri (hvs)-owl monkey lymphoid cells were found to have high levels of surface receptor for sheep erythrocytes and erythrocytes of 3 other species. these hvs-lymphoid cells lacked a receptor for modified complement. lymphoid cells of one hvs-owl monkey line showed evidence for the presence of surface immunofluorescent staining with anti-kappa chain serum. cells of an established hvs-marmoset lymphoid line had similar surface markers. of 4 established human lymphoid cell lines, all ... | 1975 | 169815 |
| immunological control of virus-induced tumors in primates. | cells infected by oncogenic viruses may transform, may develop a latent carrier state, or may be destroyed but understanding of the control of the results of infection is incomplete. even if cells transform, ultimate development of a tumor may be immunologically controlled. for example, cells of some marmoset species transform after infection with rna tumor viruses, and animals react to the transformed cells with cell-mediated and humoral immune responses. both virus specific and cross-reacting ... | 1975 | 169832 |
| nonhuman primate models for lymphoma, leukemia, and other neoplasms. | herpesvirus saimiri (hvs) is an oncogenic virus for a variety of nonhuman primates. hvs does not produce overt disease upon inoculation in the natural host (squirrel monkey) but consistently induces neoplasms including lymphomas and lymphocytic leukemias in 4 other species of monkeys. various drugs inhibit replication of hvs in vitro including cytosine arabinoside and adenine arabinoside. in addition, the lymphoma and leukemia induced in owl monkeys responds to vincristine and prednisolone, cycl ... | 1975 | 169836 |
| response to primary infection with herpesvirus saimiri in immunosuppressed juvenile and newborn squirrel monkeys. | immunosuppression of juvenile squirrel monkeys with combined azathioprine, prednisolone, and antilymphocyte globulin resulted in decreased antibody responses to viral antigens after primary infection with herpesvirus saimiri (hvs). the virus was repeatedly isolated from the oropharynx of immunosuppressed monkeys but not from untreated infected controls. thus immune factors are important in inhibiting shedding of hvs from the oropharynx. hvs could be isolated from the peripheral blood lymphocytes ... | 1975 | 170204 |
| methods for the detection of viruses in bovine serum. | an evaluation of selected commonly used procedures for the recovery of endogenous viral contaminants in bovine serum was undertaken. low speen centrifugation (25,000 x g) was found to be efficient for the recovery of bovine herpesvirus type 1 (bhv-1) and parainfluenza virus type 3(pi-3) in bovine serum. decreased infectivity titers were obtained when parainfluenza virus type 3, and to a lesser extent bovine herpes virus type 1, were concentrated using high speed centrifugation (100,000 x g) for ... | 1975 | 170306 |
| diagnosis of herpesvirus hominis infections in a general hospital laboratory. | there is a greatly increased interest in herpesvirus hominis infections especially those of type 2 associated with genital lesions or neonatal disease. physicians are eager to confirm the clinical impression with a specific virologic diagnosis such as isolation of the agent and its typing, and type-specific antibody responses. procedures are reviewed here which permit such studies in general microbiology laboratories equipped for simple cell culture and immunofluorescence. this paper recounts ex ... | 1975 | 170310 |
| physicochemical and serological characteristics of respiratory virus fluorescein-isothiocyanate conjugates for fluorescent-antibody diagnosis. | fluorescein-isothiocyanate (fitc) conjugates were prepared by improved methods from standard reference antisera to influenza a and b, mumps, parainfluenza 1, 2, 3, and 4, herpesvirus, respiratory syncytial virus, and adenovirus hexon. the antisera, prepared in a variety of animals, were fractionated three times with selected optimal concentrations of ammonium sulfate and yielded gamma globulins of adequate purity for conjugation with fitc. conjugates containing optimal fluorescein-to-protein rat ... | 1975 | 170315 |
| the effect of an immunosuppressive drug (azathioprine) on the latent infection of marmoset monkeys (callithrix jacchus) with the oncogenic herpesvirus saimiri. | callithrix jacchus (cj) marmoset monkeys can be latently infected with herpesvirus saimiri (hvs). in order to determine whether this resistance to the oncogenic potential of hvs could be due to the immune surveillance, azathioprine, a known immunosuppressive drug, was given to 7 latently infected cj marmosets. the animals died within 147 days probably from side effect caused by azathioprine, but no animal developed a tumor. | 1975 | 170499 |
| herpesvirus genitalis: a nursing perspective. | 1975 | 170599 | |
| replication of equine herpesvirus type i: resistance to hydroxyurea. | 1975 | 170739 | |
| virological studies on gynaecological patients. | endometrial epithelial cells and blood samples taken simultaneously with the curettage (first serum) of 138 patients suffering from menstrual bleeding disorders as well as materials obtained from 16 induced abortions, were studied for the presence of virus. fourteen adenovirus 2 strains were isolated from samples of the patients. endometrial epithelial cells of 35 patients were examined with immunofluorescence method and 23 of them displayed specific fluorescence referring to the presence of vir ... | 1975 | 170759 |
| exfoliative cytopathologic studies in organ transplantation iv. the cytologic diagnosis of herpesvirus in the urine of renal allograft recipients. | cellular changes of herpesvirus infection were found in 12 urine specimens from 4 renal allograft recipients. the cytologic diagnosis of herpes infection in the urine of renal allograft recipients has not been reported previously and is significant because of recent suggestions that viral infection contribute to allograft rejections. we were unable to find a consistent correlation between the cytologic diagnosis of herpesvirus and transplant rejection in the patients we studied. | 1975 | 170768 |
| fatal disseminated adenovirus infection in a renal transplant recipient. | a 61 year old woman died of diffuse interstitial adenovirus pneumonia 55 days after receiving a cadaveric renal allograft. the adenovirus was serologically distinct from the 33 known human adenovirus serotypes and appears to represent a new human adenovirus. pathologic and virological findings indicate that the pneumonia was only one manifestation of a disseminated infection, the source of which may have been a latent adenovirus infection preexisting in the donor kidney. the establishment of the ... | 1975 | 170822 |
| the epidemiology and interrelationship of cervical dysplasia and type 2 herpesvirus in a low-income housing project. | this report examines the association between cervical dysplasia and herpes simplex virus type 2 antibodies in a low-income housing project, atlanta, georgia. we established a clinic in this project at which women could receive a breast examination and papanicolaou smear and have blood drawn to be tested for herpesvirus type 2 antibodies. prevalence of herpesvirus rose sharply as age increased. there was a significant absence of antibodies in young, nulliparous women. dysplasia showed a tendency ... | 1975 | 170825 |
| eczema herpeticum. treatment with methylene blue and light. | kaposi varicelliform eruption due to herpes simplex virus (eczema herpeticum) is a serious disease in infants, with occasional fatal outcome. photoinactivation therapy consisting of local application of methylene blue followed by light exposure resulted in rapid improvement both clinically and virologically. methylene blue, at a concentration of 10(-5)m was found to be viricidal to herpesvirus in the light but not in the dark. | 1975 | 170870 |
| [proceedings: isolation of herpesvirus]. | 1975 | 170881 | |
| marek's disease--the disease and its prevention by vaccination. | marek's disease (md) is a common lymphoproliferative disease of the domestic chicken caused by a cell associated herpesvirus. vaccines used for the prophylaxis of md have been derived from non-pathogenic field marek's disease virus (mdv), pathogenic mdv and the herpesvirus of turkeys (hvt). vaccines derived from mdv have been developed by attenuation of virus strains which produce the acute form of md and virus strains which produce the classical form. they have also been developed by suitable m ... | 1975 | 170953 |
| uptake of [3h] thymidine and cell dna synthesis during the early multiplication phase of herpesvirus hominis in bhk cells. | experiments about the interaction of herpes viruses with bhk-cells during the first 6 h after infection concerning uptake and incorporation of dthd have been reported. during adsorption and penetration, the inhibition of uptake and of incorporation of [3h] dthd is sensitive to heat, but not to ultraviolet irradiation or cycloheximide. the eclipse is characterized by a strongly increased uptake of [3h] dthd and by inhibition of cell dna synthesis. both are sensitive to ultraviolet irradiation of ... | 1975 | 170989 |
| occurrence of antibodies to type 2 herpes simplex virus in the sera of town population. | in order to obtain a more detailed knowledge of the ecology of genital herpesvirus in czechoslovak geographic and socioeconomic conditions, a total of 1 246 sera of town population, collected by the method of random selection from persons of different age groups in the town of ostrava were examined in microneutralization reaction for antibodies to type 2 and type 1 herpes simplex virus. antibodies to hsv-1 were present even in the youngest age groups 0--4 and 5--9 and positive findings in the ol ... | 1975 | 171307 |
| experimental herpes simplex virus encephalitis: comparative effects of treatment with cytosine arabinoside and adenine arabinoside. | experimental herpesvirus encephalitis in weanling mice was treated with either cytosine arabinoside or adenine arabinoside to determine the comparative effectiveness of the two compounds on survival and on the concentration of virus in the brain. the uniformly fatal course of the encephalitis was not altered by any dosage of cytosine arabinoside. in contrast, treatment with adenine arabinoside resulted in long-term survival of the majority of the infected animals. the concentration of virus meas ... | 1975 | 171318 |
| direct visualization of enveloped epstein-barr herpesvirus in throat washing with leukocyte-transforming activity. | mature enveloped virions belonging to the herpes class were found in a concentrated, partially purified specimen of throat washings from a patient undergoing immunosuppressive therapy for prevention of renal homograft rejection. this throat washing contained a high titer of biologically active epstein-barr virus and no other human herpesviruses. epstein-barr virions were not detected in throat washings from patients with mononucleosis that had only low titers of transforming activity. | 1975 | 171319 |
| regulation by thymidine monophosphate and other nucleotides of thymidine kinase activity in extracts from primary rabbit kidney cells infected by hsv types 1 and 2. | in an attempt to differentiate between thymidine kinase (ec.2.4.1.21) induced by herpesvirus hominis type i (tk i) and type 2 (tk2), the different susceptibilities to the modifying effects of some thymidine analogues proved to be useful criteria: (i)2'-deoxythymidine-5'-triphosphate (dthd-5'-ppp) inhibits tk 2 at a concentration of 0-125 mm by 90%, whereas tk i is inhibited at 4-03 mm by 50%. (2) 2'-deoxythymidine-5'-monophosphate (dthd-5'-p) competitively inhibits tk 2 at all concentrations tes ... | 1975 | 171338 |
| herpesvirus antibodies and antigens in patients with cervical anaplasia and in controls. | antibody activity to herpesvirus hominis type 2 (hvh-2) in 151 women cured of cervical carcinoma (60 in situ, 91 invasive) and in 106 controls differed significantly, especially between the in situ (73%) and control (17%) groups. sera of 57 patients with cervical atypia showed an increased antibody activity to hvh-2 (58%), compared with that of the 57 matched controls (23%). antibodies to cytomegalovirus (cmv) were detected more frequently in sera of women with atypia (61%) than in sera of women ... | 1975 | 171424 |
| effect of adeno-associated virus on cancer expression by herpesvirus-transformed hamster cells. | infection of herpes simplex virus type-2-transformed hamster tumor cells with adeno-associated virus type 1 before inoculation into hamsters specifically delayed the appearance of palpable tumors and increased the survival time of the animals. the data indicated that a defective virus of humans can influence cancer expression by a virus-transformed cell. | 1975 | 171433 |
| virus-induced abortion. studies of equine herpesvirus 1 (abortion virus) in hamsters. | a hamster-adapted strain of equine herpesvirus-1 (equine abortion virus) caused severe hepatic degeneration in both pregnant and nonpregnant hamsters and, in addition, regularly induced abortion in pregnant hamsters inoculated at midgestation. in nonpregnant hamsters, the only consistently affected organ was the liver despite a prolonged viremia. newborn animals usually died 1 to 2 days after inoculation; adults died 5 to 9 days after inoculation. in pregnant hamsters, the virus had a tropism fo ... | 1975 | 171478 |
| genetics of natural resistance to herpesvirus infections in mice. | 1975 | 171586 | |
| [testing of the protective effect of cell-free lyophilized vaccine against marek's disease in field trials]. | the protective effect of a lyophilized vaccine against marek's disease ("keramvac"--pfizer), prepared from a cell-free turkey's herpesvirus (strain fc 126), was compared in field trials with losses in the group of non-vaccinated chickens. under the indicated conditions, the vaccine had only a 50.86% effectiveness. the possible causes of the reduced vaccination effect are discussed with regard to the pathomorphological and virological findings suggesting, among others, an increased incidence of t ... | 1975 | 171821 |
| [enzyme activity in cell cultures infected with herpesvirus suis]. | the activity of succinate dehydrogenase (sdh) and lactage dehydrogenase (ldh) was studied in chick-embryo fibroblast cultures after inoculation of the virulent strain "a2" and the avirulent strain "mk" of herpesvirus suum. strain "a2" reduced sdh activity, and so did strain mk, but here the decrease of enzyme activity was slower, and it did not become evident until the 24th hour. ldh activity fluctuated after "a2" infection but was generally increased, while there was no change in ldh activity, ... | 1975 | 172044 |
| acute ocular infection by type 2 herpes simplex virus in adults. | acute ocular infections in two adults were caused by type 2 herpes simplex virus (hsv) ("genital herpesvirus"). one patient had an acute blepharoconjunctivitis, the other an acute keratoconjunctivitis. genital infections had preceded the eye infections, and type 2 hsv was isolated from the eyes of both patients and from the genital lesions of one patient. this strongly suggests transmission of type 2 hsv from the genital site to the eye. | 1975 | 172050 |
| [immunovirological factors in epitheliomas of the rhinopharynx]. | the epidemiology of nasopharyngeal carcinoma (npc) suggests the intervention of genetic factors. these factors may be represented by a specific hl-a pattern (leucocyte antigens) as found in chinese npc patients (deficit of antigens corresponding to the second sublocus and discovery of a new antigen, named sin-2). the association between npc and a herpesvirus (the ebv) is based on elevated antibodies against a variety of ebv coded antigens, on cell mediated immune reactions, and on the regular pr ... | 1975 | 172172 |
| incidence of herpesvirus hominis antibodies among blood donor populations. | the microneutralization test was used to determine the occurrence of antibodies to herpesvirus hominis type 1 and type 2 in sera from patients attending the special clinic, bristol royal infirmary, with proven herpes genitalis, and in sera taken from blood donors in bath, dursley, and bristol, as well as from donors in three different prison populations. the findings in patients with herpes genitalis indicate that the test accurately reflects the antibody response expected in relation to the typ ... | 1975 | 172191 |
| detection of bovine viruses in fetal bovine serum used in cell culture. | this investigation employed a viral screening method detect endogenous bovine virus contaminants in commercially supplied fetal bovine serum. fifty-one lots of fetal bovine serum from 14 suppliers were examined. over 30% of the lots tested were found to contain bovine viruses; they included bovine virus diarrhea virus, parainfluenza type3-like virus, bovine herpesvirus-1, bovine enterovirus type 4, and an unidentified cytopathogenic agent. of the 51 lots, 20 had been pretested by the suppliers ... | 1975 | 172434 |
| inhibition of the mitogenic response of normal peripheral lymphocytes by extracts or supernatant fluids of a herpesvirus saimiri lymphoid tumor cell line. | a herpesvirus saimiri-infected marmoset lymphoid cell line (mlc-1) was examined for the presence of soluble factors which might affect lymphocyte functions and, therefore, relate to the pathogenesis of lymphoma in vivo. mlc-1 cells, cell extracts, and culture fluids were shown to reduce the spontaneous deoxyribonucleic acid (dna) synthesis of normal peripheral blood lymphocytes and to completely inhibit their response to phytohemagglutinin (pha). suppression of pha response was demonstrated agai ... | 1975 | 172449 |
| viral replication and interferon production in fetal and adult ovine leukocytes and spleen cells. | peripheral blood leukocyte and spleen cell cultures derived from adult sheep and from third-trimester (107 to 145 days of gestation) and second-trimester (70 to 98 days of gestation) fetal lambs were examined for their ability to support viral replication and to produce interferon. bluetongue virus, herpesvirus hominis type 2, and chikungunya virus failed to replicate in either leukocyte or spleen cell cultures derived from adult ewes or in cultures from second- or third-trimester fetal lambs. s ... | 1975 | 172452 |
| responses of isolator-derived japanese quail and quail cell cultures to selected animal viruses. | thirteen oncogenic and necrotizing animal viruses were assayed in life sciences, inc. (lsi)-specific pathogen-free japanese quail and lsi-specific pathogen-free chicken embryo cell cultures. nine viruses produced similar titers in the quail and chicken cell systems, whereas four viruses showed significantly higher titers in chickens. young japanese quail and chickens were inoculated with five selected avain viruses and maintained in stainless-steel isolators. comparable responses were noted in q ... | 1975 | 172527 |
| experimental horizontal transmission of herpesvirus saimiri from squirrel monkeys to an owl monkey. | herpesvirus saimiri was naturally transmitted from squirrel monkeys excreting the virus to one of two owl monkeys housed in the same cage. the owl monkey became infected approximately three months after contact was initiated. h. saimiri was consistently isolated from the peripheral lymphocytes until this animal died eight months later. during this period the owl monkey developed specific antibody to h. saimiri to a maximal neutralization index of 5.5 logs. the other monkey remained uninfected fo ... | 1975 | 172563 |
| synthesis of herpes simplex virus, vaccinia virus, and adenovirus dna in isolated hela cell nuclei. i. effect of viral-specific antisera and phosphonoacetic acid. | purified nuclei, isolated from appropriately infected hela cells, are shown to synthesize large amounts of either herpes simplex virus (hsv) or vaccinia virus dna in vitro. the rate of synthesis of dna by nuclei from infected cells is up to 30 times higher than the synthesis of host dna in vitro by nuclei isolated from uninfected hela cells. thus hsv nuclei obtained from hsv-infected cells make dna in vitro at a rate comparable to that seen in the intact, infected cell. molecular hybridization s ... | 1975 | 172658 |
| morphological response of maternal antibody-negative chickens infected with marek's disease virus (mdv), herpesvirus of turkeys (hvt) and both viruses. | 1975 | 172684 | |
| [correlations between herpesvirus and cervix carcinoma based on antigen-antibody studies]. | 1975 | 172829 | |
| herpes genitalis in guinea-pigs. i. kinetic study in infection with herpesvirus hominis type 2. | the kinetics of virus replication after vaginal infection of guinea-pigs with hvh 2/angelotti were studied in relation to the appearance of local and general symptoms. most virus was isolated from the genital tract 24-48 hours post infection. virus was first isolated from the spinal cord 48-72 hours post infection. penetration into the brain only occurred occasionally, and later. under the experimental conditions employed, no virus was found in the blood, spleen, kidneys, adrenals or inguinal ly ... | 1975 | 172946 |
| herpes genitalis in guinea-pigs. ii. morphological studies in female guinea-pigs infected with herpesvirus hominis type 2. | gross and microscopial morphological changes developing in female guinea-pigs after vaginal infection with hvh 2/angelotti were studied. in the mucosa of the external genital tract there were inflammatory changes with formation of intra-epithelial vesicles, erosions and ulcerations. in the late stages of the infection signs of inflammatory dysplasia were also observed. the infection spread into the nervous system and produced characteristic inflammatory changes. the inflammation began as a bilat ... | 1975 | 172947 |
| epstein-barr herpesvirus and infectious mononucleosis. | 1975 | 172973 | |
| equine herpesvirus-induced alterations in nuclear rna and dna polymerase activities. | 1975 | 173079 | |
| transcription of equine herpesvirus type 1: evidence for classes of transcripts differing in abundance. | 1975 | 173082 | |
| antibodies to herpesvirus hominis types 1 and 2 among women with neoplastic change of uterine cervix. | the occurrence of antibodies to herpesvirus hominis types 1 and 2 was studied in finland among patients with a neoplastic change of the uterine cervix. the following groups were studied: 220 patients with malignant or premalignant lesions of the uterine cervix, 143 control patients matched for age, socioeconomic level, marital status, home district and number of deliveries and 82 patients with breast or stomach cancer. antibodies to hvh types 1 and 2 were determined using the neutralization test ... | 1975 | 173131 |
| pathogenicity of a caprine herpesvirus. | a herpesvirus isolated from neonatal angora kids (capra hircus) with a relatively severe generalized infection was shown to be infective for adult goats as well as for kids. however, the virus lacked pathogenicity for either lambs or calves. although a nonreciprocating serologic overlap exists between the caprine virus and the antibody to bovine herpesvirus (bhv-1), results of cross immunity tests in calves indicated that the 2 viruses are immunologically distinct. on the basis of these findings ... | 1975 | 173212 |
| induction and in vitro demonstration of cellular immunity to dna and rna viruses in guinea-pigs. | guinea-pigs were immunized with different cells infected with vaccinia virus, herpes simplex virus type 1, herpesvirus saimiri, and the virus of vesicular stomatitis. development of cellular immunity against these viruses was observed with transformation of blood and spleen lymphocytes and with the migration inhibition test using peritoneal exudate cells. cellular immunity against vaccinia virus was first seen 6 days after the inoculation of cell-bound vaccinia virus by lymphocyte transformation ... | 1975 | 173485 |
| passive immunization in experimental herpesvirus hominis infection of newborn mice. | infection of newborn mice with herpesvirus hominis type 2(hvh-2) was used as an experimental model of disseminated hvh infection in newborn humans. mice were challenged with 103 plaque-forming units of hvh-2 intranasally and were given 0.2 ml of rabbit serum intraperitoneally. passive immunizations with rabbit anti-hvh-2 serum resulted in a significant decrease in mortality and prolongation of survival time. this effect correlated with the neutralizing antibody titer of the serum against hvh-2 a ... | 1975 | 173653 |
| effect of anti-herpesvirus drugs on human and bovine lymphoid function in vitro. | lymphocyte proliferative responses to phytohemagglutinin, pokeweed mitogen, and herpesvirus (herpes simplex virus and infectious bovine rhinotracheitis virus) antigens were evaluated in the presence of various concentrations of the anti-herpesvirus drugs, methylmethoxydeoxyuridine (och3ch2udr), cytosine arabinoside was inhibitory at 25 mug/ml and cytosine arabinoside was inhibitory och3ch2udr per ml, lymphocyte proliferative responses were unaffected and were not abolished even by concentrations ... | 1975 | 173654 |
| increased susceptibility to bacterial infection as a sequela of exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. | the effects of subclinical levels of 2,3,7,8-tetrachloridibenzo-p-dioxin (tcdd) on the response of mice to infection with either salmonella bern or herpesvirus suis, also known as pseudorabies virus, are reported. tcdd is a contaminant of certain commercially useful chemicals, such as chlorinated phenols or herbicides. it has been shown to cause thymic atrophy and to suppress cell-mediated immunity in laboratory animals. sublethal levels of tcdd were used: 0.5, 1,5, 10, or 20 mug/kg, given throu ... | 1975 | 173655 |