Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| once bitten, twice shy: an unusual case report of a mycotic aortic aneurysm. | primary mycotic aneurysms of the aorta are a rare, but potentially lethal condition comprising less than 1% of all aortic aneurysms. all age groups are affected but patients younger than 50 years are most susceptible. organisms commonly implicated in aortitis and mycotic aortic aneurysms include salmonella species and staphylococcus aureus(1). we present the first case report of a primary aortic mycotic aneurysm caused by capnocytophaga canimorsus, a commensal organism found in the mouth of dogs ... | 2005 | 16336402 |
| capnocytophaga canimorsus mycotic abdominal aortic aneurysm: why the mailman is afraid of dogs. | we describe the first case report of a mycotic abdominal aortic aneurysm secondary to capnocytophaga canimorsus in an immunocompetent 65-year-old man. the exposure occurred after his dog scratched his arm and subsequently licked the wound. a review of c. canimorsus, a rarely pathogenic but potentially devastating bacterium, is also presented. | 2006 | 16455937 |
| etiologic diagnosis of capnocytophaga canimorsus meningitis by broad-range pcr. | 2006 | 16482426 | |
| diagnosing capnocytophaga canimorsus infections. | we reviewed clinical and epidemiologic features of 56 human capnocytophaga canimorsus isolates submitted during a 32-year period to california's microbial diseases laboratory for identification. an increasing number of isolates identified as c. canimorsus have been submitted since 1990. many laboratories still have difficulty correctly identifying this species. | 2006 | 16494769 |
| [extensive purpura and septic schock in two patients with capnocytophaga canimorsus]. | capnocytophaga canimorsus is a gram negative bacillus present in oral flora and in saliva of dogs and cats. it can be responsible for septicaemia and meningitides in some patients after dog or cat bite two patient with a septic shock due to c. canimorsus, who presented with an extensive pupura are reported. | 2006 | 16495847 |
| [meningitis due to capnocytophaga canimorsus without dog bite]. | capnocytophaga canimorsus is a fusiform and filamentous gram-negative rod, part of the normal oral flora of dogs and cause rare human febrile acute meningitis, usually severe but curable. | 2006 | 16550132 |
| important unusual infections in australia: a critical care perspective. | to review a number of the important unusual infections in australia that can lead to critical illness. | 2001 | 16573516 |
| meningitis due to capnocytophaga canimorsus: contribution of 16s rna ribosomal sequencing for species identification. | we report a case of capnocytophaga canimorsus meningitis, which is distinguishable from previous reports by the use of 16s rrna sequencing for species identification. our case report highlights the interest of molecular new tools for bacteriological diagnosis of human infections. | 2006 | 16709541 |
| first documented capnocytophaga canimorsus infection in a species other than humans. | capnocytophaga canimorsus was cultured from an infected, dog-inflicted bite wound in a pet rabbit. the wound was treated successfully and the rabbit recovered. to our knowledge, this is the first report of a c. canimorsus infection in a species other than humans. | 2006 | 16904274 |
| the dangers of dog bites. | this report describes an unusual case of endocarditis caused by capnocytophaga canimorsus as a result of dog bite. the diagnosis could be established only by molecular techniques after amplification of bacterial dna from the infected cardiac valve. the epidemiology and management of capnocytophaga infections is discussed, as well as the role of prophylactic antibiotics in preventing these infections after dog bites. | 2007 | 16943221 |
| capnocytophaga canimorsus meningitis after routine myelography: a sentinel event identifies multiple opportunities for improvement of standard practices in radiology. | meningitis developed after a routine myelogram in a healthy patient. when capnocytophaga canimorsus was identified, investigations revealed that the patient, the radiologist, and the staff were all dog owners. multiple deviations from recommended practices in radiology were identified and corrected. the investigation of an unusual sentinel event allowed multiple interventions to be implemented simultaneously, with resultant risk reduction for subsequent radiologic procedures. | 2006 | 17015163 |
| escape from immune surveillance by capnocytophaga canimorsus. | capnocytophaga canimorsus, a commensal bacterium from dogs' mouths, can cause septicemia or meningitis in humans through bites or scratches. here, we describe and characterize the inflammatory response of human and mouse macrophages on c. canimorsus infection. macrophages infected with 10 different strains failed to release tumor necrosis factor (tnf)- alpha and interleukin (il)-1 alpha . macrophages infected with live and heat-killed (hk) c. canimorsus 5 (cc5), a strain isolated from a patient ... | 2007 | 17205476 |
| [septic shock due to capnocytophaga canimorsus]. | 2007 | 17383144 | |
| meningitis caused by capnocytophaga canimorsus: when to expect the unexpected. | in this article we review the available data concerning meningitis caused by capnocytophaga canimorsus. the clinical presentation of this rare condition is described with the emphasis on associated conditions and management issues. two additional cases, illustrating the difficulties in recognizing this rare disease, are presented. reviewing a total of 28 reported cases, a preceding bite-incident by a cat or dog, or close contact with these animals, was described in the majority of cases (89%). p ... | 2007 | 17408852 |
| [septic shock with purpura fulminans after a dog bite]. | a 61-year-old man presented with a four-day history of back pain and nonspecific abdominal pain. his condition had significantly worsened since the day before admission with generalized weakness and dyspnea. his temperature was 39.1 c, he had tachycardia and was tachypneic. peripheral cyanosis was noted. the abdomen was soft with mild epigastric tenderness. a diffuse skin rash developed with increasing petechial bleeding and central necrosis. it was revealed that he had been bitten by a dog seve ... | 2007 | 17551886 |
| [a sepsis caused by capnocytophaga canimorsus: diagnostic and therapeutic options]. | the authors present a case report of a patient with sepsis caused by gram negative rod capnocytophaga canimorsus resulting from a dog bite. the infection had a course of septic shock progressing into multiorgan failure and serious ischemic damage to the extremities. the etiologic agent was identified utilizing molecular genetic methods and its detailed microbiologic characteristics are provided below. the report also outlines diagnostic and therapeutic options of this otherwise most likely under ... | 2007 | 17703404 |
| case report: vertebral osteomyelitis/discitis as a complication of capnocytophaga canimorsus bacteremia. | a 31-year-old man with a history of congenital ventricular septal defect presented to the emergency department with 3 days of fever and palpitations. four days earlier he sustained a dog bite to the left hand with localized swelling that rapidly resolved without additional signs of infection. no other source of fever was identified on history and physical examination. he was admitted to the hospital for evaluation of the origin of the fever, including possible endocarditis. complete cardiac eval ... | 2008 | 17976760 |
| the bacteriology and antimicrobial susceptibility of infected and non-infected dog bite wounds: fifty cases. | dog bite wounds are a common reason for dogs requiring veterinary care, but there is surprisingly little data on the bacteriology of bite wounds. a prospective study was performed on dogs with various grades of bite wound to identify the bacteria present in these wounds. swabs were collected from all wounds for bacterial culture and cytology. all swabs were cultured aerobically and anaerobically and all aerobic cultures were evaluated for antibiotic susceptibility using the kirby bauer disk diff ... | 2008 | 18029118 |
| [capnocytophaga canimorsus meningitis]. | 2008 | 18063335 | |
| capnocytophaga canimorsus infection with fulminant sepsis in an asplenic patient: diagnosis by review of peripheral blood smear. | 2008 | 18098127 | |
| a case of capnocytophaga canimorsus brain abscess secondary to dog's bite. | capnocytophaga canimorsus has been recognized as an opportunistic pathogen causing systemic infections in immunocompromised individuals. it is part of the normal oral flora of the dog, and can be responsible for localized wound infections in humans in consequence of bites. this microorganism causes also septicemia, meningitis, endocarditis, ocular infections and rarely brain abscess. we describe the case of an immunocompetent 28-year-old male with temporal brain abscess from capnocytophaga canim ... | 2008 | 18366884 |
| [capnocytophaga canimorsus sepsis after a dog bite]. | a 63-year-old man was admitted to hospital. he had a history of splenectomy secondary to trauma, previous alcohol abuse, cirrhosis and oesophagus varices. the patient had been bitten by a dog three days before admittance. he rapidly developed disseminated intravascular coagulation and multiple organ dysfunction. six days after the bite, the patient died despite antibiotic treatment. the gram-negative rod capnocytophaga canimorsus was found in the blood culture. this case emphasizes the importanc ... | 2008 | 18513481 |
| capnocytophaga canimorsus: infection, septicaemia, recovery and reconstruction. | a case is presented of a life-threatening septicaemia and associated peripheral necrosing microembolic phenomenon, resulting from a dog lick to an insignificant burn wound. the isolated bacterium was capnocytophaga canimorsus, a slow-growing gram-negative bacillus commonly found in dog saliva. any clinician seeing patients with a history of dog bite/saliva contact and progressive illness should consider this bacterium as a possible offender and take special care to elicit an accurate history, sp ... | 2008 | 18566152 |
| a 52-year-old man with malaise and a petechial rash. | background: capnocytophaga canimorsus is a gram-negative, fusiform, rod-shaped organism that is part of the normal oral flora of dogs, cats, and other animals. a significant number of emergency department (ed) patients are surgically or functionally asplenic and may be at marked risk for overwhelming post-splenectomy infection (opsi). opsi has a mortality rate estimated to be up to 70%. the risk of sepsis is estimated to be 30-60 times greater after splenectomy, and c. canimorsus is one of the o ... | 2008 | 18722741 |
| genetic tools for studying capnocytophaga canimorsus. | capnocytophaga canimorsus, a commensal bacterium from canine oral flora, has been isolated throughout the world from severe human infections caused by dog bites. due to the low level of evolutionary relationship to proteobacteria, genetic methods suitable for the genus capnocytophaga needed to be established. here, we show that tn4351, derived from bacteroides fragilis, could be introduced by conjugation into c. canimorsus and conferred resistance to erythromycin. by mapping and sequencing a nat ... | 2008 | 18723653 |
| [fatal case of sepsis with capnocytophaga canimorsus after a minor dog bite]. | a healthy 54-year-old man presented at the emergency department with signs of sepsis. four days prior he was bitten and scratched by his dog. microscopy of the blood smear showed intracellular gram-negative rods. despite maximal treatment the patient died a day and a half after admission due to septic shock with multi-organ failure and disseminated intravascular coagulopathy. after extended incubation of the spleen culture a gram-negative rod was isolated and identified as capnocytophaga canimor ... | 2008 | 18788680 |
| capnocytophaga canimorsus: a human pathogen feeding at the surface of epithelial cells and phagocytes. | capnocytophaga canimorsus, a commensal bacterium of the canine oral flora, has been repeatedly isolated since 1976 from severe human infections transmitted by dog bites. here, we show that c. canimorsus exhibits robust growth when it is in direct contact with mammalian cells, including phagocytes. this property was found to be dependent on a surface-exposed sialidase allowing c. canimorsus to utilize internal aminosugars of glycan chains from host cell glycoproteins. although sialidase probably ... | 2008 | 18818736 |
| capnocytophaga canimorsus resists phagocytosis by macrophages and blocks the ability of macrophages to kill other bacteria. | capnocytophaga canimorsus is a commensal bacterium from the canine oral flora, which can cause septicemia or meningitis in humans upon bite wound infections. c. canimorsus 5 (cc5), a strain isolated from a patient with fatal septicemia, was used to investigate the interaction between c. canimorsus and j774.1 mouse macrophages. j774.1 cells infected at high multiplicity with cc5 did not phagocytose nor kill cc5 within 120 min of infection, unless the bacteria were opsonized with specific antibodi ... | 2008 | 18926295 |
| capnocytophaga canimorsus endogenous endophthalmitis in an immunocompetent host. | 2008 | 18952664 | |
| capnocytophaga canimorsus a novel pathogen for joint arthroplasty. | we report the case of a 59-year-old man with waldenstrom's macroglobulinemia and active alcohol use who presented with bilateral knee pain 5 years after a bilateral staged tka. cultures of synovial fluid and periprosthetic tissue specimens from both knees yielded, after prolonged anaerobic incubation, a catalase- and oxidase-positive gram-negative bacillus, which was identified as capnocytophaga canimorsus by 16s ribosomal rna pcr analysis. c. canimorsus, an organism that is commonly found in do ... | 2009 | 19067091 |
| a 42-year-old woman with septic shock: an unexpected source. | background: dog bites are the most common animal bite injuries occurring in the united states. estimated infection rates range between 15% and 20%. polymicrobial infections are most common. capnocytophaga canimorsus (c. canimorsus) is a gram-negative rod strongly associated with dog bites, and is known to cause life-threatening infection in humans. objectives: 1) outline epidemiology of dog bites in the united states; 2) identify host factors associated with infection, and common pathogens; 3) d ... | 2009 | 19201139 |
| community-acquired capnocytophaga canimorsus meningitis in adults: report of one case with a subacute course and deafness, and literature review. | an adult with community-acquired capnocytophaga canimorsus meningitis presented with a subacute course, deafness, and a predominantly lymphocytic csf cell count. | 2009 | 19218001 |
| capnocytophaga canimorsus. | capnocytophaga canimorsus is a commensal bacterium in the oral flora of dogs and cats. the bacterium is a zoonotic agent and has been isolated from humans, infected by dog or cat bites, scratches, licks or simply exposure to dogs or cats. here the infectious agent, its pathogenicity and potential virulence factors, infection in animals and humans, diagnostic methods, prevalence, therapy and prevention are described. suggestions for future research are given. | 2010 | 19268498 |
| community-acquired bacterial meningitis in elderly patients: experience over 30 years. | clinical characteristics, etiologies, evolution, and prognostic factors of community-acquired bacterial meningitis in elderly patients are not well known. to improve this knowledge, all episodes of community-acquired bacterial meningitis were prospectively recorded and cases occurring in patients >or=65 years old were selected. during the period 1977-2006, 675 episodes in adults (aged >or=18 yr) were recorded, with 185 (27%) in patients aged >or=65 years old; 76 were male and 109 were female, wi ... | 2009 | 19282702 |
| prevalence of capnocytophaga canimorsus in dogs and occurrence of potential virulence factors. | capnocytophaga canimorsus is a gram-negative commensal of dog's mouth causing severe human infections. a strain isolated from a human fatal infection was recently shown to have a sialidase, to inhibit the bactericidal activity of macrophages and to block the release of nitric oxide by lps-stimulated macrophages. the present study aimed at determining the prevalence of c. canimorsus in dogs and the occurrence of these hypothetical virulence factors. c. canimorsus could be retrieved from the saliv ... | 2009 | 19285152 |
| resistance of capnocytophaga canimorsus to killing by human complement and polymorphonuclear leukocytes. | capnocytophaga canimorsus is a bacterium of the canine oral flora known since 1976 to cause rare but severe septicemia and peripheral gangrene in patients that have been in contact with a dog. it was recently shown that these bacteria do not elicit an inflammatory response (h. shin, m. mally, m. kuhn, c. paroz, and g. r. cornelis, j. infect. dis. 195:375-386, 2007). here, we analyze their sensitivity to the innate immune system. bacteria from the archetype strain cc5 were highly resistant to kil ... | 2009 | 19307219 |
| man's best friend? infective endocarditis due to capnocytophaga canimorsus. | infective endocarditis caused by zoonotic microorganisms is an uncommon clinical entity. a 55-year-old man was diagnosed with endocarditis due to capnocytophaga canimorsus, a commensal bacterium contained in the saliva of dogs, that involved the aortic and tricuspid valves and was complicated by a para-aortic valve abscess and aorta-to-right atrial fistula. the patient was successfully treated with antibiotic therapy and surgical intervention. c canimorsus endocarditis should be considered in pa ... | 2009 | 19340358 |
| bite-related and septic syndromes caused by cats and dogs. | bite infections can contain a mix of anaerobes and aerobes from the patient's skin and the animal's oral cavity, including species of pasteurella, streptococcus, fusobacterium, and capnocytophaga. domestic cat and dog bite wounds can produce substantial morbidity and often require specialised care techniques and specific antibiotic therapy. bite wounds can be complicated by sepsis. disseminated infections, particularly those caused by capnocytophaga canimorsus and pasteurella multocida, can lead ... | 2009 | 19555903 |
| molecular characterization of capnocytophaga canimorsus and other canine capnocytophaga spp. and assessment by pcr of their frequencies in dogs. | capnocytophaga canimorsus can be a virulent pathogen, whereas c. cynodegmi is of low virulence. heterogeneity within these species, their frequency in dogs, and pathogenicity factors are largely unknown. strains from blood cultures from patients presumptively identified as c. canimorsus (n = 25) and as c. cynodegmi by rrs analysis (n = 4), blood cultures from dogs (n = 8), blood cultures from cats (n = 2), and cultures from swabs from dog mouths (n = 53) were analyzed. pcr-restriction fragment l ... | 2009 | 19641058 |
| [an autopsy case involving severe sepsis due to capnocytophaga canimorsus infection]. | capnocytophaga canimorsus, a commensal bacterium from the carine mouth, causes septicemia in human beings through bites or scratches. we report a case of a 60-year-old man contracting septicemia due to c. canimorsus infection after a dog bite who died less than 12 hours after admission. we observed neutrophils with intracytoplasmic bacilli in the peripheral blood smear. we discuss clinical presentation and autopsy findings. | 2009 | 20034321 |
| prevalence of capnocytophaga canimorsus and capnocytophaga cynodegmi in dogs and cats determined by using a newly established species-specific pcr. | capnocytophagacanimorsus and capnocytophagacynodegmi, fastidious gram-negative rods, are commensal microbes thriving in the oral cavities of dogs and cats. c. canimorsus can sometimes cause fatal systemic infections in humans. in the present study, we established a specific pcr which could identify and distinguish c. canimorsus from c. cynodegmi. the prevalence of capnocytophaga spp. in dogs and cats was determined using this method. c. canimorsus was detected in 74% of dogs and 57% of cats. c. ... | 2010 | 20144514 |
| capnocytophaga canimorsus infections in the netherlands: a nationwide survey. | a retrospective nationwide survey on the occurrence of capnocytophaga canimorsus and capnocytopaga cynodegmi infections in the netherlands over 3 years showed 32 cases, of which 31 were caused by c. canimorsus and one by an unspecified oxidase-positive capnocytophaga strain. twenty-eight patients had been diagnosed by blood culture, one by culture from both blood and cerebrospinal fluid (csf), one by culture from a conjunctival swab, and two patients by 16s rrna gene amplification by pcr directl ... | 2011 | 20167010 |
| an unusual case of septic shock in a geriatric patient. | capnocytophaga canimorsus is a gram-negative rod that is a normal inhabitant of the oral flora of most dogs, cats and other animals. clinically significant infections of humans by this common organism are extremely rare. we present a case of an 87-year-old woman who presented with septic shock and multiorgan system failure. blood cultures were positive for a gram-negative rod that five days after admission was identified as c. canimorsus. she was treated aggressively with intravenous fluid resus ... | 2010 | 20391818 |
| fatal dog bite in the absence of significant trauma: capnocytophaga canimorsus infection and unexpected death. | sudden and unexpected nontraumatic death in individuals with asplenia or hyposplenia is usually due to fulminant bacterial sepsis, most often involving streptococcus pneumoniae, neisseria meningitidis, and hemophilus influenzae. we report a case of a previously well 40-year-old man who died 5 hours after hospital admission. at autopsy waterhouse-friderichsen syndrome was identified and capnocytophaga canimorsus was subsequently isolated on antemortem blood cultures. infection of humans with this ... | 2010 | 20407357 |
| postsplenectomy infection - strategies for prevention in general practice. | the spleen plays a crucial role in human defence against infection. patients who are asplenic or hyposplenic are at increased risk of severe sepsis due to specific organisms. overwhelming postsplenectomy infection (opsi) has a mortality rate of up to 50%. | 2010 | 20628676 |
| [permanent hearing loss following dog bite. capnocytophaga canimorsus caused severe infection with sepsis]. | 2010 | 20812562 | |
| identification of bacteria associated with feline chronic gingivostomatitis using culture-dependent and culture-independent methods. | feline chronic gingivostomatitis (fcgs) is a chronic inflammatory disease of the oral cavity that causes severe pain and distress. there are currently no specific treatment methods available and little is known regarding its aetiology, although bacteria are thought to play a major role. the purpose of this study was to identify the oral bacterial flora in normal and diseased cats. oral swabs were obtained from the palatoglossal folds of eight cats (three normal and five fcgs) and were subjected ... | 2011 | 20828946 |
| capnocytophaga canimorsus sepsis. | 2010 | 20836255 | |
| [fatal sepsis due to capnocytophaga canimorsus after dog bite]. | a 56-year-old man was bitten by a dog. 8 days later he was admitted to a hospital because of severe deterioration of his clinical situation. he developed the clinical picture of fulminant sepsis. in spite of aggressive intensive care therapy the patient died 24 hours later. capnocytophaga canimorsus was identified from initial blood cultures. this gram-negative rod is part of the normal oral flora of dogs and cats. it can be spread to humans by bites, licking or scratches and causes severe infec ... | 2010 | 20981594 |
| prioritizing emerging zoonoses in the netherlands. | to support the development of early warning and surveillance systems of emerging zoonoses, we present a general method to prioritize pathogens using a quantitative, stochastic multi-criteria model, parameterized for the netherlands. | 2010 | 21085625 |
| "beware man's best friend". | case report. | 2010 | 21102283 |
| presence of the oral bacterium capnocytophaga canimorsus in the tooth plaque of canines. | capnocytophaga canimorsus is a potentially pathogenic microorganism when transmitted to humans from the oral cavity of canines. although there is some knowledge about the frequency of occurrence in canines, it is uncertain whether there is a correlation between its occurrence and lifestyle, health, or breed of dog. samples of tooth plaque from a total of 131 canines were collected, cultured on selective media, and tested using physiological and molecular analyses to help discern the presence of ... | 2010 | 21239122 |
| capnocytophaga canimorsis a cause of septicaemia following a dog bite: a case review. | described in this study is the case of a 53-year-old woman who developed a life-threatening infection caused by the bacterium capnocytophaga canimorsus (c. canimorsus), subsequent to being bitten by a dog. the patient presented to an emergency department with a 24-h history of diarrhoea and vomiting with dehydration but within 36 h of presentation developed an overwhelming severe sepsis with septic shock, disseminated intravascular coagulation, acute renal failure, metabolic acidosis and threate ... | 2011 | 21242095 |
| septicemia due to capnocytophaga canimorsus following dog bite in an elderly male. | a previously healthy, 67-year-old, man with past medical history of myocardial infarction and hypertension was rushed to the emergency room after sudden onset of fever, chills, severe rigors, hypotension, tachycardia and vomiting. the patient was diagnosed as being in septic shock, and investigations revealed intracellular gram-negative bacilli in polymorphonuclear leukocytes in the peripheral smear. a history of dog contact was elicited after this very unusual and rare finding. cultures confirm ... | 2011 | 21623093 |
| the n-glycan glycoprotein deglycosylation complex (gpd) from capnocytophaga canimorsus deglycosylates human igg. | c. canimorsus 5 has the capacity to grow at the expenses of glycan moieties from host cells n-glycoproteins. here, we show that c. canimorsus 5 also has the capacity to deglycosylate human igg and we analyze the deglycosylation mechanism. we show that deglycosylation is achieved by a large complex spanning the outer membrane and consisting of the gpd proteins and sialidase siac. gpdd, -g, -e and -f are surface-exposed outer membrane lipoproteins. gpddef could contribute to the binding of glycopr ... | 2011 | 21738475 |
| capnocytophaga canimorsus septicaemia in an asplenic patient with systemic lupus erythematosus. | asplenic patients are highly susceptible to infections with encapsulated bacteria such as capnocytophaga canimorsus, a gram negative bacillus which is a commensal organism in cat and dog saliva. we describe the first case of septic shock due to c canimorsus infection occurring in a 51-year-old woman with functional asplenism related to systemic lupus erythematosus with antiphospholipid antibodies. because of the potential severity of this infection, physicians have to be aware of its occurrence ... | 2009 | 21747901 |
| the genome and surface proteome of capnocytophaga canimorsus reveal a key role of glycan foraging systems in host glycoproteins deglycosylation. | capnocytophaga canimorsus are commensal gram-negative bacteria from dog's mouth that cause rare but dramatic septicaemia in humans. c. canimorsus have the unusual property to feed on cultured mammalian cells, including phagocytes, by harvesting the glycan moiety of cellular glycoproteins. to understand the mechanism behind this unusual property, the genome of strain cc5 was sequenced and analysed. in addition, cc5 bacteria were cultivated onto hek 293 cells and the surface proteome was determine ... | 2011 | 21762219 |
| [The presence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in companion animals in the Netherlands]. | The presence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in companion animals in The Netherlands. This article reports about a research that is done to determine the presence of Capnocytophaga canimorsus and Capnocytophaga cynodegmi in companion animals in the Netherlands using a species specific PCR in combination with classic microbial isolation. Because of the high presence of the bacteria in the mouth of especially cats and dogs (respectively 21 and 19%) and the severe conseque ... | 2011 | 21870573 |
| Complete genome sequence of the dog commensal and human pathogen Capnocytophaga canimorsus strain 5. | Capnocytophaga canimorsus is a commensal Gram-negative bacterium, originally isolated from a dog's mouth, that causes septicemia in humans. C. canimorsus has the unusual ability to feed on host cells, including phagocytes. This capacity depends on surface-exposed glycan-foraging systems. Here we present the first complete genome sequence of a C. canimorsus strain (Cc5). | 2011 | 21914877 |
| capnocytophaga canimorsus endocarditis with root abscess in a patient with a bicuspid aortic valve. | 2009 | 21977282 | |
| 'Biting the hand that feeds': fever and altered sensorium following a dog bite. | Capnocytophaga canimorsus infection is the most severe and rapidly progressive bacterial infection transmitted by dog bite and fortunately is very rare. The authors describe a 68-year-old gentleman who presented in an acute confusional state 2 days after having been bitten on the left hand by a dog. Despite immediate broad-spectrum intravenous antibiotics, he developed significant sequelae including disseminated intravascular coagulopathy, microvascular emboli leading to peripheral necrosis, wid ... | 2011 | 22101595 |
| three cases of capnocytophaga canimorsus meningitis seen at a regional hospital in one year. | three cases of meningitis caused by the fastidious gram-negative rod capnocytophaga canimorsus have been observed at a regional hospital in 1 y. the difficulties connected with the correct diagnosis by classical culturing methods in contrast to molecular methods, as well as possible reasons for the accumulation of cases, are discussed. | 2012 | 22292539 |
| [capnocytophaga canimorsus meningitis diagnosed by means of a 16s rrna analysis]. | capnocytophaga canimorsus is a gram-negative bacterial species hosted in the oral cavity of dogs. c. canimorsus can cause sepsis, meningitis and endocarditis. penicillin is the drug of choice. however, the species is a slow-grower and sometimes missed in blood cultures. patients with a history of alcoholism, splenectomy or immunodeficiency are at an increased risk of contracting serious infections with c. canimorsus following dog bites. we report a case story of c. canimorsus meningitis contract ... | 2012 | 22293076 |
| identification of blood and wound isolates of c. canimorsus and c. cynodegmi using vitek2 and maldi-tof. | capnocytophaga canimorsus and c. cynodegmi are gram negative bacteria that can be transmitted to humans from dogs or cats and cause serious infections. routine bacteriological methods, including fermentation and phenotypic tests are insufficient to correctly identify c. canimorsus or c. cynodegmi. the aim of this study was to evaluate the performance of vitek2 and maldi-tof in identification of these bacteria. twenty two isolates that were identified as c. canimorsus / c. cynodegmi by 16s rrna s ... | 2012 | 22454088 |
| two dog-related infections leading to death: overwhelming capnocytophaga canimorsus sepsis in a patient with cystic echinococcosis. | capnocytophaga canimorsus is a fastidious, capnophilic, fusiform, and filamentous gram-negative rod. it is part of the normal oral flora of dogs and cats and can cause an infection in humans, but is of generally low virulence in healthy individuals. a case of fatal sepsis due to capnocytophaga canimorsus in a 46-year-old woman with clinically silent cystic echinococcosis discovered postmortem is present. she had been bitten by a dog 3 days before the symptoms appeared. the family had owned the d ... | 2012 | 22491382 |
| two cases of infectious purpura fulminans and septic shock caused by capnocytophaga canimorsus transmitted from dogs. | we report 2 cases of capnocytophaga canimorsus-induced septicaemia complicated by purpura fulminans in previously healthy individuals, both of whom had been exposed to dog saliva prior to disease. they both presented with purpuric skin lesions, as well as the tetrad of abdominal symptoms, haemolytic anaemia, metabolic acidosis, and renal failure, which may be common in c. canimorsus-associated purpura fulminans. the patients survived after treatment with broad-spectrum antibiotics and supportive ... | 2012 | 22497463 |
| the lipopolysaccharide from capnocytophaga canimorsus reveals an unexpected role of the core-oligosaccharide in md-2 binding. | capnocytophaga canimorsus is a usual member of dog's mouths flora that causes rare but dramatic human infections after dog bites. we determined the structure of c. canimorsus lipid a. the main features are that it is penta-acylated and composed of a "hybrid backbone" lacking the 4' phosphate and having a 1 phosphoethanolamine (p-etn) at 2-amino-2-deoxy-d-glucose (glcn). c. canimorsus lps was 100 fold less endotoxic than escherichia coli lps. surprisingly, c. canimorsus lipid a was 20,000 fold le ... | 2012 | 22570611 |
| 'biting the hand that feeds': fever and altered sensorium following a dog bite. | capnocytophaga canimorsus infection is the most severe and rapidly progressive bacterial infection transmitted by dog bite and fortunately is very rare. the authors describe a 68-year-old gentleman who presented in an acute confusional state 2 days after having been bitten on the left hand by a dog. despite immediate broad-spectrum intravenous antibiotics, he developed significant sequelae including disseminated intravascular coagulopathy, microvascular emboli leading to peripheral necrosis, wid ... | 2011 | 22714608 |
| asplenic fulminant sepsis secondary to a dog bite complicated by toxic epidermal necrolysis/stevens-johnson syndrome. | we report a case of asplenic fulminant sepsis in australia following a dog bite which was complicated by toxic epidermal necrolysis/stevens-johnson syndrome (tens/sjs). capnocytophaga canimorsus, the infective organism, is a rare cause of septicaemia: a high degree of suspicion of this unusual organism and its early aggressive management is paramount. the diagnostic and management difficulties of tens/sjs in the context of a patient with fulminant sepsis, dic and on inotropes are also highlighte ... | 2012 | 22864159 |
| capnocytophaga canimorsus sepsis with associated thrombotic thrombocytopenic purpura. | capnocytophaga canimorsus, a bacterium commonly transmitted via dog bites, is known to cause sepsis in immunocompromised patients. thrombotic thrombocytopenic purpura and hemolytic uremic syndrome are rare complications of infection. the authors present a case of c canimorsus sepsis and thrombotic thrombocytopenic purpura in an asplenic patient and review the relevant literature. | 2013 | 22990045 |
| infections in alcoholic liver disease. | alcoholic individuals are at increased risk of infection in general, in part because of immune defects. in addition, associated situations, such as depressed mental status, increase risk to specific syndromes such as lung abscess related to depressed consciousness and aspiration. social factors related to hygiene and living situations are also linked to specific microorganisms, such as mycobacteria tuberculosis, bartonella quintana, vibrio vulnificus, and capnocytophaga canimorus.. | 2012 | 23101982 |
| capnocytophaga canimorsus infection presenting with complete splenic infarction and thrombotic thrombocytopenic purpura: a case report. | animal bites are typically harmless, but in rare cases infections introduced by such bites can be fatal. capnocytophaga canimorsus, found in the normal oral flora of dogs, has the potential to cause conditions ranging from minor cellulitis to fatal sepsis. the tendency of c. canimorsus infections to present with varied symptoms, the organism's fastidious nature, and difficulty of culturing make this a challenging diagnosis. rarely, bacterial cytotoxins such as those produced by c. canimorsus may ... | 2012 | 23267527 |
| shock following a cat scratch. | a 49-year-old man with fever, pain in both legs, purpuras and cyanosis was admitted to hospital. he was a heavy drinker, but did not have diabetes or other immunosuppressive disease. on admission, he was in shock, with haematological findings suggestive of disseminated intravascular coagulation, and liver and kidney failure. the presence of a scratch wound on his face caused by a cat, and linear, gram-negative rods phagocytosed by polynuclear leucocytes on peripheral blood smear suggested capnoc ... | 2013 | 23314879 |
| capnocytophaga canimorsus prosthetic aortitis in an hiv-positive woman. | a 49-year-old woman with a 15-year history of hiv-hepatitis c virus coinfection had aortic valve and ascending aorta replacement in 2007. she presented with abdominal pain, episodic diarrhea, and profuse sweating in 2010. thoracoabdominal positron emission tomography-computed tomography finally suggested infectious aortitis, a diagnosis confirmed by a blood culture positive for capnocytophaga canimorsus. | 2013 | 23698520 |
| capnocytophaga canimorsus infection in cats: abcd guidelines on prevention and management. | capnocytophaga canimorsus and capnocytophaga cynodegmi are part of the normal bacterial flora of the oral cavity of dogs and cats. c canimorsus is more pathogenic and causes more severe infections in humans. | 2013 | 23813822 |
| facial purpura associated with capnocytophaga canimorsus septicaemia; role of sunlight? | 2014 | 23816547 | |
| capnocytophaga canimorsus sepsis following bmt in a patient with aml: possible association with functional asplenia. | 2014 | 23974607 | |
| [fulminant sepsis due to capnocytophaga canimorsus: diagnosis by matrix-assisted laser desorption/ionization-time of flight mass spectrometry]. | 2014 | 24103212 | |
| 'bobo-newton syndrome': an unwanted gift from man's best friend. | capnocytophaga canimorsus is a facultative gram-negative bacillus that is typically a constituent of the oral flora of dogs and cats. it was first isolated by bobo and newton in 1976 from a man presenting with meningitis following a dog bite. transmission to humans follows various animal-related injuries, which may be gross or subtle. c canimorsus can cause a spectrum of syndromes ranging from skin and soft tissue infection to invasive disease such as meningitis or endocarditis. the present arti ... | 2013 | 24489563 |
| renal failure due to capnocytophaga canimorsus generalized shwartzman reaction from a dog bite (df-2 nephropathy). | we report a case of a 54-year-old man who developed gram-negative sepsis with multiorgan failure and generalized shwartzman reaction after sustaining a dog bite. the causative organism was the fastidious gram-negative rod capnocytophaga canimorsus, which is a commensal organism found in the oral flora of dogs and cats. more than 30 years after it was first described and despite technological advances in identification techniques, proper identification of this organism remains a challenge. in lig ... | 2014 | 24688203 |
| distribution of capnocytophaga canimorsus in dogs and cats with genetic characterization of isolates. | capnocytophaga canimorsus, which is often found in the oral cavities of dogs and cats, is sometimes transmitted to humans, causing severe infection. to elucidate the risk of c. canimorsus in humans and animals, this study was undertaken to characterize this bacterium epidemiologically and genetically. we examined the distribution of c. canimorsus in dogs and cats, and analyzed the correlation between the presence of bacteria and individual factors statistically. we also compared c. canimorsus is ... | 2014 | 24745627 |
| overwhelming capnocytophaga canimorsus infection in a patient with asplenia. | patients with asplenia are prone to overwhelming infections due to encapsulated organisms. we report a 62-year-old man presenting with fever and weakness. his medical history was significant for splenectomy and owning a dog as pet. the patient on examination had evidence of animal bite and scratch marks on his lower extremity and developed dry gangrene of multiple digits of his upper extremity soon after admission. the patient's initial blood cultures were positive for gram-negative rods, but no ... | 2014 | 24759159 |
| the capnocytophaga canimorsus isolate that caused sepsis in an immunosufficient man was transmitted by the large pine weevil hylobius abietis. | the first vector-borne capnocytophaga canimorsus sepsis case is presented. an immunocompetent male who denied any contact with canines and who worked in a sawmill was bitten on his neck by a large pine weevil (hylobius abietis l.; coleoptera: curculionidae). bacteriological diagnosis was confirmed by 16s rrna gene sequence analysis. | 2014 | 24808240 |
| nmr-based structural analysis of the complete rough-type lipopolysaccharide isolated from capnocytophaga canimorsus. | we here describe the nmr analysis of an intact lipopolysaccharide (lps, endotoxin) in water with 1,2-dihexanoyl-sn-glycero-3-phosphocholine as detergent. when hplc-purified rough-type lps of capnocytophaga canimorsus was prepared, (13)c,(15)n labeling could be avoided. the intact lps was analyzed by homonuclear ((1)h) and heteronuclear ((1)h,(13)c, and (1)h,(31)p) correlated one- and two-dimensional nmr techniques as well as by mass spectrometry. it consists of a penta-acylated lipid a with an α ... | 2014 | 24993825 |
| antibiotic treatment following a dog bite in an immunocompromized patient in order to prevent capnocytophaga canimorsus infection: a case report. | capnocytophaga canimorsus is a commensal bacterium found in the saliva of dogs and cats. clinically significant infections in humans after a bite are often associated with the presence of immune deficiency. early recognition and appropriate treatment are crucial for patient survival. in addition, patients with immune deficiency are susceptible to serious life-threatening nosocomial infections, which may also influence the prognosis of patients with capnocytophaga canimorsus infection. | 2014 | 24997586 |
| hypertensive emergency and type 2 myocardial infarction resulting from pheochromocytoma and concurrent capnocytophaga canimorsus infection. | a diagnosis of myocardial infarction is made using a combination of clinical presentation, electrocardiogram and cardiac biomarkers. however, myocardial infarction can be caused by factors other than coronary artery plaque rupture and thrombosis. we describe an interesting case presenting with hypertensive emergency and type 2 myocardial infarction resulting from pheochromocytoma associated with capnocytophaga canimorsus infection from a dog bite. we also review current literature on the managem ... | 2014 | 25024773 |
| a case of capnocytophaga canimorsus sacral abscess in an immunocompetent patient. | we report a unique case of sacral capnocytophaga canimorsus abscess successfully treated with surgery and antibiotics. close contact to a dog was assumed to be the most likely source of infection. established risk factors for invasive c. canimorsus infection such as splenectomy, alcoholism or overt immunosuppression could not be identified. the role of cigarette smoking, portal of entry and the possible relevance of altered skin microbiota as well as the diagnostic value of polymerase chain reac ... | 2015 | 25182960 |
| new iron acquisition system in bacteroidetes. | capnocytophaga canimorsus, a dog mouth commensal and a member of the bacteroidetes phylum, causes rare but often fatal septicemia in humans that have been in contact with a dog. here, we show that c. canimorsus strains isolated from human infections grow readily in heat-inactivated human serum and that this property depends on a typical polysaccharide utilization locus (pul), namely, pul3 in strain cc5. pul are a hallmark of bacteroidetes, and they encode various products, including surface prot ... | 2015 | 25368114 |
| capnocytophaga canimorsus bacteremia presenting with acute cholecystitis after a dog bite. | capnocytophaga canimorsus is part of normal gingival flora of dogs and cats. the organism can cause septicemia, meningitis, and endocarditis in humans after contact with dogs or cats. in spite of the frequency of gastrointestinal symptoms in c. canimorsus infection patients, specific gastrointestinal disease or clinical images have not been reported. we report a case of c. canimorsus bacteremia presenting with acute cholecystitis in elderly woman. she suffered from general fatigue and right uppe ... | 2015 | 25445385 |
| a rare case of waterhouse-friderichsen syndrome caused by capnocytophaga canimorsus in an immunocompetent patient. | a 53-year-old caucasian male with hypertension and active tobacco abuse presented to a community hospital with a 2-day history of vague abdominal pain, myalgia and increased lethargy after being bitten on his right hand by the family dog while camping just 3 days prior to symptom onset. he expired within 90 min upon arrival to our intensive care unit. pre-mortem blood cultures grew a fastidious gram-negative aerobic rod that was identified as capnocytophaga canimorsus. autopsy findings showed mu ... | 2015 | 25676131 |
| acute generalized livedo racemosa caused by capnocytophaga canimorsus identified by maldi-tof ms. | independent of the size of the dog and the type of injury, serious infections may follow a dog bite and these may result in the abrupt onset of multiorgan failure. early recognition of the warning signs with regard to the underlying severity of the infection is of the utmost importance. reticulate skin eruptions constitute a precursory phenomenon. | 2015 | 25677725 |
| glycan-foraging systems reveal the adaptation of capnocytophaga canimorsus to the dog mouth. | capnocytophaga canimorsus is known to form two kinds of cells on blood agar plates (coccoid and bacillary), evoking phase variation. when grown in coculture with animal cells these bacteria appeared only as bacilli, but in the presence of vancomycin they were round, indicating that coccoid shapes likely result from weakening of the peptidoglycan layer. polysaccharide utilization locus 5 (pul5) and sialidase mutant bacteria, unable to retrieve glycans from glycoproteins, grew less than wild-type ... | 2015 | 25736888 |
| capnocytophaga canimorsus: an emerging cause of sepsis, meningitis, and post-splenectomy infection after dog bites. | newly named in 1989, capnocytophaga canimorsus is a bacterial pathogen found in the saliva of healthy dogs and cats, and is transmitted to humans principally by dog bites. this review compiled all laboratory-confirmed cases, animal sources, and virulence attributes to describe its epidemiology, clinical features, and pathogenesis. an estimated 484 patients with a median age of 55 years were reported, two-thirds of which were male. the case-fatality rate was about 26%. its clinical presentations ... | 2015 | 25828064 |
| draft genome sequences of three capnocytophaga canimorsus strains isolated from septic patients. | capnocytophaga canimorsus is a bacterium from the normal oral flora of dogs and cats that causes rare generalized infections in humans. in an attempt to determine whether infections could be caused by a subset of strains and to identify pathogenicity factors, we sequenced the genomes of three strains isolated from human infections. | 2015 | 26021910 |
| draft genome sequences of three capnocytophaga canimorsus strains isolated from healthy canine oral cavities. | here, we present the draft genome sequences of three strains of capnocytophaga canimorsus, each isolated from a different dog's mouth. genome analysis provided evidence that these organisms may belong to a different nonpathogenic subtype of c. canimorsus. | 2015 | 26021912 |
| draft genome sequences of three capnocytophaga cynodegmi strains isolated from the oral cavity of healthy dogs. | here, we present the draft genome sequences of three strains of capnocytophaga cynodegmi. in contrast to the very close relationship among them, c. cynodegmi and capnocytophaga canimorsus differ dramatically in terms of virulence in humans. comparative genomics provided some understanding on how capnocytophaga species may switch from being dog commensals to human pathogens. | 2015 | 26021913 |
| diseases transmitted by man's best friend: the dog. | the relationship between dogs and humans is ancient and mutually beneficial. dogs have served people well as companions, workmates, guides, and protectors. however, on occasion, dogs may injure humans through biting or may transmit pathogens resulting in a large number of problems ranging from a trivial rash to life-threatening bacteremia. given that there are more than 80 million pet dogs in the united states, it is worth knowing the potential problems that can result from canine exposure. annu ... | 2015 | 26350317 |
| rapid killing of capnocytophaga canimorsus and capnocytophaga cynodegmi by human whole blood and serum is mediated via the complement system. | capnocytophaga canimorsus (cani) and capnocytophaga cynodegmi (cyno) are found in the oral cavities of dogs and cats. they can be transmitted to humans via licks or bites and cause wound infections as well as severe systemic infections. cani is considered to be more pathogenic than cyno, but the pathophysiological mechanisms are not elucidated. cani has been suggested to be resistant to serum bactericidal effects. thus, we hypothesized that the more invasive cani would exhibit a higher degree of ... | 2015 | 26405637 |
| only a subset of c. canimorsus strains is dangerous for humans. | capnocytophaga canimorsus are gram-negative bacteria living as commensals in the mouth of dogs and cats. c. canimorsus cause rare but life-threatening generalized infections in humans that have been in contact with a dog or a cat. over the last years we collected 105 c. canimorsus strains from different geographical origins and from severe human infections or healthy dogs. all these strains were analyzed by 16s rdna sequencing and a phylogenetic tree revealed two main groups of bacteria instead ... | 2015 | 26421271 |
| nmr-based structural analysis of the complete rough-type lipopolysaccharide isolated from capnocytophaga canimorsus. | 2015 | 26475523 |