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bioavailable constituents/metabolites of pomegranate (punica granatum l) preferentially inhibit cox2 activity ex vivo and il-1beta-induced pge2 production in human chondrocytes in vitro.abstract: several recent studies have documented that supplementation with pomegranate fruit extract inhibits inflammatory symptoms in vivo. however, the molecular basis of the observed effects has not been fully revealed. although previous studies have documented the inhibition of nitric oxide and cyclooxygenase (cox) activity in vitro by plant and fruit extracts added directly into the culture medium but whether concentrations of bioactive compounds sufficient enough to exert such inhibitory e ...200818554383
safety assessment of pomegranate fruit extract: acute and subchronic toxicity studies.pomegranate (punica granatum l.) fruit is widely consumed as fresh fruit and juice. because of its potential for health benefits, pomegranate fruit extracts have been commonly marketed as dietary supplements in recent years. the objective of the present study was to investigate potential adverse effects, if any, of a standardized pomegranate fruit extract in rats following subchronic administration. the extract was standardized to 30% punicalagins, the active anomeric ellagitannins responsible f ...200818571823
therapeutic applications of pomegranate (punica granatum l.): a review.the pomegranate, punica granatum l., is an ancient, mystical, unique fruit borne on a small, long-living tree cultivated throughout the mediterranean region, as far north as the himalayas, in southeast asia, and in california and arizona in the united states. in addition to its ancient historical uses, pomegranate is used in several systems of medicine for a variety of ailments. the synergistic action of the pomegranate constituents appears to be superior to that of single constituents. in the p ...200818590349
medicinal values of fruit peels from citrus sinensis, punica granatum, and musa paradisiaca with respect to alterations in tissue lipid peroxidation and serum concentration of glucose, insulin, and thyroid hormones.peel extracts from citrus sinensis, punica granatum, and musa paradisiaca were investigated for their effects on tissue lipid peroxidation (lpo) and on the concentration of thyroid hormones, insulin, and glucose in male rats. in vitro inhibition of h(2)o(2)-induced lpo in red blood cells of rats by 0.25, 0.50, 1.0, and 2.0 microg/ml c. sinensis, p. granatum, and m. paradisiaca peel extracts was observed in a dose-specific manner. maximum inhibition was observed at 0.50 microg/ml c. sinensis, 2.0 ...200818598183
protective effects of standardized pomegranate (punica granatum l.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts.exposure to ultraviolet (uv) radiation has been associated with several acute and chronic conditions, including sunburn, edema, hyperplasia, immunosuppression, photoaging, and skin cancer. the role of naturally occurring phytochemicals in the prevention of such uv-related conditions has captured increased interest. pomegranate ( punica granatum l.) is a rich source of polyphenolics, which have been shown to exert anti-inflammatory, antioxidant, and anticarcinogenic activity in numerous in vivo a ...200818717570
antidiabetic potential of citrus sinensis and punica granatum peel extracts in alloxan treated male mice.an investigation on the effects of four different concentrations of peel extract from citrus sinensis (cs) or punica granatum (pg) in male mice revealed the maximum glucose lowering and antiperoxidative activities at 25 mg/kg of cs and 200 mg/kg of pg. in a separate experiment their potential was evaluated with respect to the regulation of alloxan induced diabetes mellitus. while a single dose of alloxan (120 mg/kg) increased the serum levels of glucose and alpha-amylase activity, rate of water ...200718806305
antioxidant activity of some jordanian medicinal plants used traditionally for treatment of diabetes.medicinal plants are being used extensively in jordanian traditional medicinal system for the treatment of diabetes symptoms. twenty one plant samples were collected from different jordanian locations and used for antioxidant evaluation. the level of antioxidant activity was determined by dpph and abts assays in relation to the total phenolic contents of the medically used parts. the most frequently used plant parts as medicines were fruit, shoot and leaves. the total phenolic contents of methan ...200818817155
screening of nepalese crude drugs traditionally used to treat hyperpigmentation: in vitro tyrosinase inhibition.south-east asian population is daily exposed to strong sunlight. as a result, the majority of population will have darker, ethnic skin. moreover, many people suffer from dark spots, hyperpigmentation, which is considered to be a skin disorder and causes psychological disturbance. to treat dark spots, most of the population will still rely on traditionally used crude drugs, knowledge about which is transferred from generation to generation. fifty-two crude drugs were selected based on the survey ...200818822041
fungal control of pathogenic fungi isolated from wild plants in taif governorate, saudia arabia.twenty two plants were collected from taif governorate and identified as: euphorbia glomerifera, juniperus procera, launaea mucronata, capparis dcidua, punica granatum, opuntia ficus, prunus persica, eucalyptus globulus, medicago sativa, artemisia monosperma, trichodesma calathiforme, artemisia judaica, foeniculum vulgare, phagnalon sinaicum, rumex dentatus, asphodelus aestives, pulicaria crispa, launae sonchoides, forsskaolea tenacissima, arnebia hispidissima, avena spp and aerva lanata. pathog ...200718928069
antidiabetic effect of punica granatum flowers: effect on hyperlipidemia, pancreatic cells lipid peroxidation and antioxidant enzymes in experimental diabetes.the present study investigated the effects of punica granatum aqueous extract (pgaq) on streptozotocin (stz) induced diabetic rats by measuring fasting blood glucose, lipid profiles (atherogenic index), lipid peroxidation (lpo) and activities of both non-enzymatic and enzymatic antioxidants. diabetes was induced by single intraperitoneal injection of stz (60 mg/kg) to albino wistar rats. the increase in blood glucose level, total cholesterol (tc), triglycerides (tg), low-density lipoprotein chol ...200918950673
hepatoprotective role and antioxidant capacity of pomegranate (punica granatum) flowers infusion against trichloroacetic acid-exposed in rats.this study was designed to investigate the protective and antioxidant properties of punica granatum (pg) beverage against trichloroacetic acid (tca)-exposure in rats. the hepatopreventive and antioxidant potential of the plant's infusion was evaluated by measuring level of serum enzymes, antioxidant defense systems (ads) and lipid peroxidation content in various organs of rats. three experimental groups: a (untreated=control), b (only tca-treated) and c (tca+pg treated). according to the results ...200919022327
an ethnobotanical study of medicinal plants in chandauli district of uttar pradesh, india.chandauli district is one of the less studied regions of india for its ethnobotanical values. the present paper synthesizes the first report related to the documentation and conservation of ethnomedicinal plants of chandauli district and their socio-economic relationship with the forests and its resources.200919022368
evaluation of antioxidant activity, colour and some nutritional characteristics of pomegranate (punica granatum l.) juice and its sour concentrate processed by conventional evaporation.in this study the antioxidant activity, colour and some nutritional characteristics of pomegranate juice (pj) and its traditional sour concentrate (cpj), produced in denizli, turkey, were analysed. the total anthocyanin content of pj was found to be 492.9 mg/l but it was not determined in cpj. the total phenolics were also found to be 3,246 and 9,870 microg/ml in pj and cpj, respectively. the antioxidant activity (percentage of inhibition of on peroxidation in linoleic acid system) of cpj was de ...200919031321
antimicrobial activities of pomegranate rind extracts: enhancement by addition of metal salts and vitamin c.punica granatum l. or pomegranates, have been reported to have antimicrobial activity against a range of gram positive and negative bacteria. pomegranate formulations containing ferrous salts have enhanced although short-term, antibacteriophage activities which are rapidly diminished owing to instability of the ferrous combination. the aim of this study was to determine the antimicrobial activities of combinations of pomegranate rind extracts (pre) with a range of metals salts with the added sta ...200819077299
central nervous system activity of acute administration of ethanol extract of punica granatum l. seeds in mice.role of ethanolic extract of p. granatum seeds on central nervous system (cns) in animal models of elevated plus maze test, barbiturate-induced sleeping time, tail suspension test, hot-plate and tail-flick test was studied. p. granatum (pg) extract was administered to young and aged mice at single doses of 100, 250 and 500 mg/kg, perorally while diazepam (1 mg/kg), morphine (5 mg/kg) and imipramine (30 mg/kg) were used intraperitoneally as standard drugs. the results showed that pg extract at al ...200819245177
international multidimensional authenticity specification (imas) algorithm for detection of commercial pomegranate juice adulteration.the pomegranate fruit ( punica granatum ) has become an international high-value crop for the production of commercial pomegranate juice (pj). the perceived consumer value of pj is due in large part to its potential health benefits based on a significant body of medical research conducted with authentic pj. to establish criteria for authenticating pj, a new international multidimensional authenticity specifications (imas) algorithm was developed through consideration of existing databases and co ...200919249817
protective effect of pomegranate-derived products on uvb-mediated damage in human reconstituted skin.solar ultraviolet (uv) radiation, particularly its uvb (290-320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer. uvb radiation causes dna damage, protein oxidation and induces matrix metalloproteinases (mmps). photochemoprevention via the use of botanical antioxidants in affording protection to human skin against uvb damage is receiving increasing attention. pomegranate, from the tree punica granatum, contains anthocyanins and hydrolys ...200919320737
pomegranate fruit components modulate human thrombin.pomegranate (punica granatum) is an important source of polyphenols with assessed antioxidant properties. the aims of this study were: (i) the characterization of the monomeric phenolic variability on each isolated fruit component (endocarp, mesocarp, aril); (ii) the study on the effect of pomegranate fruit components on human thrombin amidolytic activity. collectively, our data show that pomegranate components contain bioactive metabolites (mainly ellagic acid) and suggest a potential role for ...200919358882
exploring the ameliorative potential of punica granatum in dextran sulfate sodium induced ulcerative colitis in mice.the present study was designed to investigate the ameliorative potential of punica granatum in dextran sulfate sodium (dss) induced ulcerative colitis. dss (2%) was administered orally in drinking water for 7 days to induce ulcerative colitis. the extent and severity of ulceration was analysed macroscopically, histopathologically and using a disease activity index. myeloperoxidase (mpo), a specific marker of inflammation; histamine, a marker of mast cell degranulation; superoxide anion generatio ...200919367659
embryo protective effect of pomegranate (punica granatum l.) fruit extract in adriamycin-induced oxidative stress.the possible protective role of pomegranate (punica granatum l.) fruit extract which has shown antioxidant capacity higher than that of red wine and green tea was evaluated against adriamycin-induced oxidative stress in chick embryos. adriamycin (adr), an anthracycline broad spectrum of chemotherapeutic drug is used for the treatment of variety of cancers; however, its prolonged use is limited by an irreversible, dose-dependant and progressive cardiomyopathy, hepatotoxicity and general toxicity ...200919374262
antimicrobial activity of six pomegranate (punica granatum l.) varieties and their relation to some of their pomological and phytonutrient characteristics.arils from six pomegranate (punica granatum l.) varieties grown in the mediterranean region of turkey were tested for their antimicrobial properties by the agar diffusion and minimum inhibitory concentration (mic) methods against seven bacteria: (bacillus megaterium dsm 32, pseudomonas aeruginosa dsm 9027, staphylococcus aureus cowan 1, corynebacterium xerosis uc 9165, escherichia coli dm, enterococcus faecalis a10, micrococcus luteus la 2971), and threefungi (kluvyeromyces marxianus a230, rhodo ...200919471201
punica granatum peel extract protects against ionizing radiation-induced enteritis and leukocyte apoptosis in rats.radiation-induced enteritis is a well-recognized sequel of therapeutic irradiation. therefore we examined the radioprotective properties of punica granatum peel extract (ppe) on the oxidative damage in the ileum. rats were exposed to a single whole-body x-ray irradiation of 800 cgy. irradiated rats were pretreated orally with saline or ppe (50 mg/kg/day) for 10 days before irradiation and the following 10 days, while control rats received saline or ppe but no irradiation. then plasma and ileum s ...200919478462
ability of certain plant extracts traditionally used to treat ciguatera fish poisoning to inhibit nitric oxide production in raw 264.7 macrophages.ciguatera fish poisoning (cfp) is an intertropical ichthyosarcotoxism that manifests in complex assortment of symptoms in humans. ciguatoxins (ctxs), issued from gambierdicus spp., are causative agents of this intoxication. we have recently demonstrated that a pacific ctx (p-ctx-1b) strongly modulated inos expression, leading to overproduction of nitric oxide (no) in raw 264.7 murine macrophage cells. no produced in large amounts is involved in a wide range of pathophysiological processes. many ...200919501268
three new species of piricaudiopsis from southern china.piricaudiopsis punicae sp. nov., p. rosae sp. nov. and p. rhaphidophorae sp. nov., occurring respectively on dead branches of punica granatum, rosa chinensis and rhaphidophora decursiva were collected from tropical forest in southern china. they differ from the three previously described piricaudiopsis species in conidial morphology and proliferation of the conidiogenous cell. the presence or absence of percurrent proliferation of the conidiogenous cells and conidial appendages and the height of ...200919537214
antiplasmodial activity of punica granatum l. fruit rind.sun-dried rind of the immature fruit of punica granatum l. (punicaceae) (pg) is presently used as a herbal formulation (omaria) in orissa, india, for the therapy and prophylaxis of malaria. the aims of this study were (i) to assess in vitro the antiplasmodial activity of the methanolic extract, of a tannin enriched fraction and of compounds/metabolites of the antimalarial plant, (ii) to estimate the curative efficacy of the pg extracts and (iii) to explore the mechanism of action of the antiplas ...200919577622
pomegranate (punica granatum) purified polyphenol extract inhibits influenza virus and has a synergistic effect with oseltamivir.influenza epidemics cause numerous deaths and millions of hospitalizations each year. because of the alarming emergence of resistance to anti-influenza drugs, there is a need to identify new naturally occurring antiviral molecules. we tested the hypothesis that pomegranate polyphenol extract (ppe) has anti-influenza properties. using real time pcr, plaque assay, and tcid 50% hemagglutination assay, we have shown that ppe suppresses replication of influenza a virus in mdck cells. ppe inhibits agg ...200919586764
antimicrobial activity of pomegranate (punica granatum l.) fruit peels.food-borne diseases such as listeriosis and diseases caused by the emergence of multi-drug resistant pathogens (e.g. staphylococcus aureus) are globally recognized as environmental hazards to the food supply and human health. natural inhibitors for pathogenic microorganisms have been explored in many plants. the antimicrobial activity against some food-borne pathogens by various extracts from pomegranate fruit peels was evaluated using both in vitro (agar diffusion) and in situ (food) methods. t ...200919632734
in vitro and in vivo antibacterial activity of punica granatum peel ethanol extract against salmonella.punica granatum is commonly used in korea as a traditional medicine for the treatment of pathogenic bacteria. in this study, we investigated the in vitro and in vivo antimicrobial activity of p. granatum peel etoh extract (pgpe) against 16 strains of salmonella. the minimal inhibitory concentrations of pgpe were in the range of 62.5-1000 mug ml(-1). in addition, the in vivo antibacterial activity of the pgpe extract was examined in a s. typhimurium infection mouse model. mice were initially infe ...200919687188
eric-pcr-generated genomic fingerprints and their relationship with pathogenic variability of xanthomonas campestris pv. punicae, the incitant of bacterial blight of pomegranate.bacterial blight caused by xanthomonas campestris pv. punicae (xcp) has emerged as a potential threat in pomegranate (punica granatum) cultivation in india. here, we report the genomic fingerprints and their correlation with virulence pattern of xcp isolates from maharashtra and delhi. the genomic fingerprints of xcp isolates were generated using enterobacterial repetitive intergenic consensus (eric) sequence-based primers, and virulence level was based on their reaction upon infiltration to sus ...200919705201
the effect of pomegranate (punica granatum l.) byproducts and ellagitannins on the growth of human gut bacteria.the consumption of pomegranate products leads to a significant accumulation of ellagitannins in the large intestines, where they interact with complex gut microflora. this study investigated the effect of pomegranate tannin constituents on the growth of various species of human gut bacteria. our results showed that pomegranate byproducts and punicalagins inhibited the growth of pathogenic clostridia and staphyloccocus aureus. probiotic lactobacilli and bifidobacteria were generally not affected ...200919705832
the effects of pomegranate seed extract and beta-sitosterol on rat uterine contractions.the aim of this study was to investigate the effects of pomegranate (punica granatum l., punicaceae) seed extract on uterine contractility. pomegranate seeds were methanolic extracted and their constituents analyzed using gas chromatography and mass spectrometry. isometric force was measured in strips of longitudinal rat myometrium and the effects of pomegranate seed extract studied. we found beta-sitosterol to be the main constituent of the extract (16%) and its effects were also investigated. ...201019966214
effects of fruit ellagitannin extracts, ellagic acid, and their colonic metabolite, urolithin a, on wnt signaling.recent data suggest that ellagitannins (ets), a class of hydrolyzable tannins found in some fruits and nuts, may have beneficial effects against colon cancer. in the stomach and gut, ets hydrolyze to release ellagic acid (ea) and are converted by gut microbiota to urolithin a (ua; 3,8-dihydroxy-6h-dibenzopyran-6-one) type metabolites, which may persist in the colon through enterohepatic circulation. however, little is known about the mechanisms of action of either the native compounds or their m ...201020014760
effect of pomegranate juice on angiotensin ii-induced hypertension in diabetic wistar rats.acute subcutaneous administration of angiotensin ii (ang ii) causes a rise in blood pressure in diabetic wistar rats. diabetes was induced using streptozotocin (70 mg/kg, i.v.). chronic administration of pomegranate juice (pj) extract (100 mg/kg and 300 mg/kg; p.o. for 4 weeks) obtained from punica granatum (punicaceae) fruits reduced the mean arterial blood pressure and vascular reactivity changes to various catecholamines and also reversed the biochemical changes induced by diabetes and ang ii ...201020020514
antimutagenicity of some flowers grown in thailand.the mutagenicity of dichloromethane, methanol and water extracts of antigonon leptopus hook. & arn., curcuma sessilis gage, hibiscus rosa-sinensis linn., ixora coccinea linn., millingtonia hortensis linn., nelumbo nucifera gaertn., plumeria obtusa linn., punica granatum linn., rhinacanthus nasutus ((linn.) kurz.) and syzygium malaccense ((linn.) merr.& perry) before and after nitrite treatment was firstly investigated in the ames test. their antimutagenicity against the product of the reaction m ...201020100534
effect of walnut leaf, coriander and pomegranate on blood glucose and histopathology of pancreas of alloxan induced diabetic rats.mechanism of most of herbal used for diabetes mellitus treatment has not been well defined. this study was performed to investigate hypoglycemic effect of walnut leaf (juglans regia l.), coriander leaf (coriandrum sativum l.) or pomegranate seed (punica granatum l.), and their possible role on pancreatic tissue. diabetes mellitus was induced in 20 adult male sprague dawley rats and the animals were divided into four groups; three of them fed a diet supplemented with about 15 gram (60 g/ kg body ...200720161893
protective effects of punica granatum seeds extract against aging and scopolamine induced cognitive impairments in mice.dementia is one of the age related mental problems and characteristic symptom of various neurodegenerative diseases including alzheimer's disease. this impairment probably is due to the vulnerability of the brain cells to increased oxidative stress during aging process. many studies have shown that certain phenolic antioxidants attenuate neuronal cell death induced by oxidative stress. the present work was undertaken to assess the effect of ethanolic extract of punica granatum seeds on cognitive ...200820162041
phytotherapeutics: an evaluation of the potential of 1000 plants.the aim of this review is to evaluate and summarize the available scientific information on the commonest plant extracts marketed in western countries. in view of the intense, ongoing search for new plant extracts with powerful anti-inflammatory activity, we paid particular attention to this topic. the aim is to provide broad coverage of as many potentially useful plants as possible and then to focus on those with the greatest therapeutic potential.201020175810
new sterol esters from the flowers of punica granatum linn.two new beta-sitosterol esters have been isolated from the flowers of punica granatum linn. (punicaceae) along with the known compounds n-tricosane (3), n-heptacosanyl n-hexanoate (4), olean-5,12-dien-3beta-ol-28-oic acid (5), and olean-12-en-3beta-ol-28-oic acid (6). the structures of the new phytosterols have been elucidated as stigmast-5-en-3beta-ol-3beta-dodecanoate (beta-sitosterol laurate, 1) and stigmast-5-en-3beta-ol-3beta-tetradecanoate (beta-sitosterol myristate, 2) on the basis of spe ...200920183312
effect of traditional korean medicinal (tkm) triherbal extract on the innate immune system and disease resistance in paralichthys olivaceus against uronema marinum.we report the effect of aqueous-, ethanol- and methanol-solvent-derived extracts of three traditional korean herbs, punica granatum, chrysanthemum cinerariaefolium and zanthoxylum schinifolium, by monitoring the innate immune mechanisms, such as phagocytosis activity, respiratory burst activity, alternative complement activity and lysozyme activity and the functional immunity in terms of percentage mortality and relative percent survival (rps) in olive flounder (paralichthys olivaceus) against u ...201020207485
the wound healing activity of flower extracts of punica granatum and achillea kellalensis in wistar rats. 201020210088
antibacterial activity of medicinal plants against pathogens causing complicated urinary tract infections.seventeen indian folklore medicinal plants were investigated to evaluate antibacterial activity of aqueous, ethanol and acetone extracts against 66 multidrug resistant isolates of major urinary tract pathogens (escherichia coli, klebsiella pneumoniae, pseudomonas aeruginosa and enterococcus faecalis) by disc diffusion method. ethanol extract of zingiber officinale and punica granatum showed strong antibacterial activity against escherichia coli. ethanol extracts of terminalia chebula and ocimum ...200920336211
assessment of geographic and host-associated population variations of the carob moth, ectomyelois ceratoniae, on pomegranate, fig, pistachio and walnut, using aflp markers.the carob moth, ectomyelois ceratoniae (zeller 1839) (lepidoptera: pyralidae) is the most important pest of pomegranate, punica granatum l. (myrtales: ponicaceae), in iran. in this study, 6 amplified fragment length polymorphism primer combinations were used to survey the genetic structure of the geographic and putative host-associated populations of this pest in iran. an amova was performed on test populations. pairwise differences, mantel test, multidimensional analysis, cluster analysis and m ...020345296
[isolation of cryptococcus neoformans from living tree trunk hollows in denizli city center, turkey].cryptococcus neoformans is a basidiomycetous yeast leading to life-threatening infections in human and animals. it has been isolated from decaying hollows and fissures from various tree species in different parts of the world. the isolation of the yeast from the environment is less in the eastern part of mediterranean area. only one c. neoformans strain from debris of eucalyptus camaldulensis in the blossoming period, has been reported by consecutive studies done in suspected areas since the las ...201020455402
extract of punica granatum inhibits skin photoaging induced by uvb irradiation.punica granatum (pomegranate) is kind of a fruit consumed fresh or in beverage. it has been widely used in traditional medicine in various parts of the world. in this study, we examined the efficacy of a punica granatum (pg) extract in protecting skin against uvb-induced damage using cultured human skin fibroblasts.201020465664
efficacy of punica granatum extract on in-vitro and in-vivo control of trichomonas vaginalis.trichomoniasis vaginalis is now an important worldwide health problem. metronidazole has so far been used in treatment, but the metronidazole-resistant strains and unpleasant adverse effects have been developed. treatment of patients with metronidazole refractory vaginal trichomoniasis constitutes a major therapeutic challenge and treatment options are extremely limited. the last 7 years have seen over seven times as many publication indexed by midline dealing with pomegranate (punica granatum) ...201020503601
pomegranate (punica granatum l.) juice supplementation attenuates isoproterenol-induced cardiac necrosis in rats.the aim of the present study was to evaluate the efficacy of pre-supplementation with pomegranate (punica granatum l.) juice (pj) on heart weight, infarct size, plasma marker enzymes of cardiac damage, lipid peroxidation, endogenous enzymatic and non-enzymatic antioxidants, cardiac atpases and histopathology of isoproterenol (ip)-induced cardiac necrosis (cn) in rats. rats treated with ip (85 mg/kg, s.c.) for 2 days at an interval of 24 h caused significant (p < 0.05) infarct in myocardium and i ...201020509006
antidiabetic screening of commercial botanical products in 3t3-l1 adipocytes and db/db mice.numerous botanicals are purported to improve glucose metabolism and diabetic risk factors with varying degrees of supportive evidence. we investigated 203 commercially available botanical products representing 90 unique botanical species for effects on lipogenic activity in differentiating 3t3-l1 adipocytes. anti-inflammatory activity of 21 of these products was further assessed in tumor necrosis factor alpha (tnfalpha)-stimulated, mature 3t3-l1 adipocytes. from these results, rho-isoalpha acids ...201020521979
potent antifungal activity of extracts and pure compound isolated from pomegranate peels and synergism with fluconazole against candida albicans.activity-guided repeated fractionation of crude hydro alcoholic extract prepared from the fruit peel of punica granatum on a silica-gel column yielded a compound that exhibited strong antifungal activity against candida spp. based on spectral analyses, the compound was identified as punicalagin. punicalagin showed strong activity against candida albicans and candida parapsilosis, with mics of 3.9 and 1.9 microg/ml, respectively. the combination of punicalagin and fluconazole showed a synergistic ...201020541606
medicinal plants as immunosuppressive agents in traditional iranian medicine.immunomodulation using medicinal plants provides an alternative to conventional chemotherapy for several diseases, especially when suppression of inflammation is desired. the "canon of medicine", the epochal work of avicenna, the great persian scientist of the middle ages, provides comprehensive information about medicinal plants which used to cure inflammatory illnesses in traditional iranian medicine. taking into consideration that the mechanisms of damage in these illnesses are mediated by im ...201020574119
use of asiatic pennywort centella asiatica aqueous extract as a bath treatment to control columnaris in nile tilapia.to develop antibiotic-free and chemical-free aquaculture, it is necessary to have natural substances to control diseases of aquatic animals. the aim of this study was to find an herb having therapeutic effect against columnaris, a fish disease caused by the bacterium flavobacterium columnare. of all tested herbs (including kalmegh andrographis paniculata, candle bush cassia alata, asiatic pennywort centella asiatica, mangosteen garcinia mangostana, pomegranate punica granatum, and guava psidium ...201020575361
effect of punica granatum solvent extracts on immune system and disease resistance in paralichthys olivaceus against lymphocystis disease virus (ldv).we report the effect of aqueous, ethanol, and methanol solvent leaf extracts of punica granatum on innate immune mechanisms, such as phagocytosis activity, respiratory burst activity, alternative complement activity, lysozyme activity and functional immunity in terms of percentage cumulative mortality and relative percent survival (rps) in olive flounder paralichthys olivaceus naturally infected with lymphocystis disease virus (ldv) after 8 weeks. infected fish were intraperitoneally administere ...201020624470
ellagitannins of the fruit rind of pomegranate (punica granatum) antagonize in vitro the host inflammatory response mechanisms involved in the onset of malaria.the sun-dried rind of the immature fruit of pomegranate (punica granatum) is presently used as a herbal formulation (omaria, orissa malaria research indigenous attempt) in orissa, india, for the therapy and prophylaxis of malaria. the pathogenesis of cerebral malaria, a complication of the infection by plasmodium falciparum, is an inflammatory cytokine-driven disease associated to an up-regulation and activity of metalloproteinase-9 and to the increase of tnf production. the in vitro anti-plasmo ...201020642847
antifungal activity of extracts of some plants used in brazilian traditional medicine against the pathogenic fungus paracoccidioides brasiliensis.paracoccidioidomycosis (pcm) is a systemic granulomatous disease caused by paracoccidioides brasiliensis almeida (onygenales) that requires 1-2 years of treatment. in the absence of drug therapy, the disease is usually fatal, highlighting the need for the identification of safer, novel, and more effective antifungal compounds. with this need in mind, several plants employed in brazilian traditional medicine were assayed on p. brasiliensis and murine macrophages. extracts were prepared from 10 pl ...201020645716
in vitro antifungal activity of indirubin isolated from a south indian ethnomedicinal plant wrightia tinctoria r. br.acalypha indica, cassia alata, lawsonia inermis, punica granatum, thespesia populnea and wrightia tinctoria are folklore medicines extensively used in the treatment of ringworm infections and skin related diseases in tamil nadu, india.201020691774
genetic diversity in inter-simple sequence repeat profiles across natural populations of indian pomegranate (punica granatum l.).pomegranate (punica granatum l.), in the monogeneric family punicaceae, is found in iran, afghanistan, india and mediterranean countries. iran is considered to be its primary centre of origin. in india, pomegranate occurs naturally only in the western himalayan regions of jammu and kashmir, himachal pradesh and uttarakhand states. however, there is no information about genetic variation in wild pomegranate at population level. in this paper, we describe genetic diversity across natural populatio ...201020701705
broad spectrum antimutagenic activity of antioxidant active fraction of punica granatum l. peel extracts.over the past few decades, scientific research has indicated a credible basis for some of the traditional ethnomedicinal uses of pomegranate. this study aims to evaluate the broad spectrum antioxidant and antimutagenic activities of peel extracts of pomegranate. the sequentially extracted punica granatum peel fractions were tested for their antioxidant activity by dpph free radical scavenging, phosphomolybdenum, frap (fe(3+) reducing power) and cuprac (cupric ions (cu(2+)) reducing ability) assa ...201020708098
screening of medicinal plants against leishmania amazonensis.leishmaniasis is a widespread tropical infection caused by different species of leishmania protozoa. there is no immunoprophylaxis (vaccination) available for leishmania infections and conventional treatments are unsatisfactory; therefore antileishmanial drugs are urgently needed. natural products are attractive due to their structural diversity.201020731558
pomegranate extract inhibits the proliferation and viability of mmtv-wnt-1 mouse mammary cancer stem cells in vitro.pomegranate (punica granatum l.) is known to possess anticancer activities. the effects of a standardized extract of pomegranate (pe) on a mouse mammary cancer cell line (designated wa4) derived from mouse mmtv-wnt-1 mammary tumors were examined in this study. the wa4 cell line has been previously characterized as containing a majority of cells possessing stem cell characteristics. pe inhibited the proliferation of wa4 cells in a time- and concentration-dependent manner. this was due to an arres ...201020811693
protective effects of punica granatum in experimentally-induced gastric ulcers.in the present investigation standardized aqueous methanolic extract of punica (amp) was used for its possible ulcer protective activity in wistar rats against different experimental models. preliminary phytochemical screening of amp reveals the presence of saponin, tannins, and flavonoids, which may be responsible for its activity. hptlc finger prints of amp showed the presence of 12 spots at different (retention factor) rf values. oral administration of amp (490 and 980 mg/kg bw) significantly ...201020846023
wound healing activity of malva sylvestris and punica granatum in alloxan-induced diabetic rats.the flowers of malva sylvestris linn. (malvaceae) and punica granatum linn. (punicaceae) are important medicinal plants in iranian traditional medicine (unani) whose have been used as remedy against edema, bum, wound and for their carminative, antimicrobial and anti-inflammatory activities. the diethyl ether extract of m. sylvestris and p. granatum flowers were used to evaluate the wound healing activity at 200 mg/kg/day dose in alloxan-induced diabetic rats. wounds were induced in wister rats d ...201020873419
antifungal efficacy of punica granatum, acacia nilotica, cuminum cyminum and foeniculum vulgare on candida albicans: an in vitro study.the establishment and maintenance of oral microbiota is related not only to interbacterial coaggregations but also to interactions of these bacteria with yeasts. hence, it is important for agents used in the treatment of oral diseases to have antifungal properties for effective therapy. objective: the main purpose of this study was to evaluate the in vitro antifungal efficacy of punica granatum, acacia nilotica, cuminum cyminum and foeniculum vulgare on candida albicans.201020930339
oral feeding of pomegranate fruit extract inhibits early biomarkers of uvb radiation-induced carcinogenesis in skh-1 hairless mouse epidermis.pomegranate from the plant punica granatum l. possesses strong antioxidant and anti-inflammatory properties. recently, we have demonstrated that treatment of normal human epidermal keratinocytes with pomegranate fruit extract (pfe) inhibited uvb-mediated activation of nuclear factor kappa b (nf-κb) and mitogen activated protein kinases pathways. here, we evaluated the effect of pfe on early biomarkers of photocarcinogenesis employing skh-1 hairless mice. pfe was provided in drinking water (0.2%, ...201020946358
growth inhibitory, antiandrogenic, and pro-apoptotic effects of punicic acid in lncap human prostate cancer cells.prostate cancer is a commonly diagnosed cancer in men, and dietary chemoprevention by pomegranate (punica granatum) extracts has shown noticeable benefits. in this study, we investigated the growth inhibitory, antiandrogenic, and pro-apoptotic effects of 13 pure compounds found in the pomegranate in androgen-dependent lncap human prostate cancer cells. cells deprived of steroid hormones were exposed to increasing concentrations (1-100 μm) of pomegranate compounds in the presence of 0.1 nm dihydr ...201021067181
antimicrobial potential of some plant extracts against candida species.the increase in the resistance to antimicrobial drugs in use has attracted the attention of the scientific community, and medicinal plants have been extensively studied as alternative agents for the prevention of infections. the candida genus yeast can become an opportunistic pathogen causing disease in immunosuppressive hosts. the purpose of this study was to evaluate dichloromethane and methanol extracts from mentha piperita, rosmarinus officinalis, arrabidaea chica, tabebuia avellanedae, puni ...201021180915
screening of certain medicinal plants from india for their anti-quorum sensing activity.discovery of quorum sensing (qs) system to coordinate virulence and biofilm formation in bacterial pathogens has triggered search for safe, stable and non-toxic anti-qs compounds from natural products. ethanolic extracts of 24 indian medicinal plants were tested by agar well and disc diffusion assay for anti-qs activity using chromobacterium violaceum (cv12472 and cvo26) reporter strains. ahl from c. violaceum cv31532 was isolated and partially purified for its use in cvo26 based bioassay. effec ...201021250604
differential attraction of aedes albopictus in the field to flowers, fruits and honeydew.sugar is the main source of energy for the activities of mosquitoes; however, information on the vital sugar feeding of aedes albopictus in the field is scanty and often anecdotal. using glue traps and baits, we evaluated the attraction of ae. albopictus to 28 different, potential sugar sources. control traps were baited with either sugar-water solution or water alone, and since there was no significant difference between these controls, the water control was used as the standard for comparison. ...201121310142
2-methyl-pyran-4-one-3-o-ß-d-glucopyranoside isolated from leaves of punica granatum inhibits the tnfa-induced cell adhesion molecules expression by blocking nuclear transcription factor-?b (nf-?b).here, we report bioactivity-guided isolation, purification and characterization of a novel compound, 2-methyl-pyran-4-one-3-o-ß-d-glucopyranoside (mpg) from the leaves of punica granatum. the structure of mpg was established on the basis of its detailed spectral analyses. we demonstrated that mpg not only inhibited the expression of cell adhesion molecules but also significantly blocked its functional consequence, that is, the adhesion of neutrophils on human endothelial cells monolayer. to eluc ...201121315792
effect of dipping in pomegranate (punica granatum) fruit juice phenolic solution on the shelf life of chicken meat under refrigerated storage (4°c).an experiment was conducted to evaluate the effect of dipping in pomegranate fruit juice phenolics (pfjp) solution on the shelf life of chicken meat held under refrigerated storage at 4°c. breast muscle obtained from spent hens was dipped (1:2w/v; muscle: liquid) in sterile water or in sterile water with 0.02% (v/v) pfjp, packed, stored at 4°c for 28 days and samples were analyzed on 2 days of intervals. thiobarbituric acid reactive substance values were lower in samples treated with pfjp. total ...201121345604
pathogenicity for onion and genetic diversity of isolates of the pathogenic fungus colletotrichum gloeosporioides (phyllachoraceae) from the state of pernambuco, brazil.onion anthracnose, caused by colletotrichum gloeosporioides, is one of the main diseases of onions in the state of pernambuco. we examined the pathogenicity of 15 c. gloeosporioides strains and analyzed their genetic variability using rapds and internal transcribed spacers (its) of the rdna region. ten of the strains were obtained from substrates and hosts other than onion, including chayote (sechium edule), guava (psidium guajava), pomegranate (punica granatum), water from the capibaribe river, ...201121365546
an aqueous pomegranate peel extract inhibits neutrophil myeloperoxidase in vitro and attenuates lung inflammation in mice.punica granatum peel aqueous extract (pge) is widely used to treat disorders such as inflammation, ulcers and infections, but its pharmacological target is not known. in this study we investigated the effect of pge on human neutrophil reactive oxygen species (ros) production in vitro and on lps-induced lung inflammation in vivo in mice. neutrophils were isolated and ros generation was measured by luminol-amplified chemiluminescence. superoxide anion generation was detected by the cytochrome c re ...201121376769
cardioprotective effect of whole fruit extract of pomegranate on doxorubicin-induced toxicity in rat.cardioprotective effects of various plants are generally attributed to their antioxidant activity. the whole fruit extract of pomegranate (wfep), punica granatum l. (punicaceae), has a potent antioxidant activity. objective: to investigate cardioprotective effect of wfep against doxorubicin (dox)-induced cardiotoxicity in rats.201121391840
effect of a mixed herb-enriched diet on the innate immune response and disease resistance of paralichthys olivaceus against philasterides dicentrarchi infection.we investigated the effect of a mixed herb-enriched diet obtained from pomegranate punica granatum, dalmatian chrysanthemum chrysanthemum cinerariaefolium, and mastic-leaved prickly-ash zanthoxylum schinifolium on innate immune mechanisms (e.g., phagocytosis activity, respiratory burst activity, alternative complement activity, lysozyme activity, and disease resistance) of olive flounder paralichthys olivaceus against the scuticociliate philasterides dicentrarchi. all experimental groups were ch ...201021413507
effect of punica granatum (pomegranate) on sperm production in male rats treated with lead acetate.the present study was designed to determine whether the treatment with an ethanolic extract of pomegranate (eep) (punica granatum) can be useful for the treatment of the deleterious effect of lead acetate (la) administration on sperm production in rats. the effects of eep were compared with those of ascorbic acid (aa) that is a strong antioxidant and has been shown to reverse lead-induced damage on the reproductive system. the rats were divided into five different groups: those received distille ...201121417630
genetic relationships among wild pomegranate (punica granatum) genotypes from coruh valley in turkey.the pomegranate has been used traditionally in coruh valley in turkey for a long time; fruits are harvested from wild, semi-domesticated and cultivated trees. in the valley, it occurs in general along with olive trees. we sampled 23 wild-grown pomegranate genotypes sampled from different parts of coruh valley and compared them using rapd primers to determine genetic variability. eighty-six rapd primers were used for molecular characterizations, among which 12 gave reliable polymorphic patterns. ...201121425096
screening of traditional chinese medicinal plants for quorum-sensing inhibitors activity.the misuse of antibiotics has contributed to widespread development of antimicrobial resistance among clinically significant bacterial species. alternative approaches other than those using antibiotics are needed in the fight against infectious diseases. quorum sensing (qs) is an intercellular signaling and gene regulatory mechanism, which is used by a number of opportunistic pathogenic bacteria in determining virulence gene expression. the study of qs may yield another strategy for disease cont ...201121439518
hydroalcoholic extract based-ointment from punica granatum l. peels with enhanced in vivo healing potential on dermal wounds.the present study reports for the first time, the in vivo wound healing potential of punica granatum l. peels. a 5% (w/w) methanolic extract based-ointment was formulated and evaluated for its wound healing in guinea pigs. the ointment was applied in vivo on the paravertebral area of twelve excised wounded models once a day for 10 consecutive days. the ointment significantly enhanced the wound contraction and the period of epithelialization as assessed by the mechanical (contraction rate, tensil ...201121466954
punica granatum protects against oxidative stress in pc12 cells and oxidative stress-induced alzheimer's symptoms in mice.abstract alzheimer's disease (ad) is a progressive degenerative brain disorder that is characterized by neuronal loss, neurofibrillary tangles, and the abnormal deposition of senile plaque and amyloid β peptide (aβ). the brains of ad patients are under intense oxidative stress. the overproduction of aβ leads to aβ-associated free radical oxidative stress. in this study, the antioxidative and neuronal protective effects of punica granatum extract were investigated against oxidative stress-induced ...201121631359
a pomegranate (punica granatum l.) wd40-repeat gene is a functional homologue of arabidopsis ttg1 and is involved in the regulation of anthocyanin biosynthesis during pomegranate fruit development.anthocyanins are the major pigments responsible for the pomegranate (punica granatum l.) fruit skin color. the high variability in fruit external color in pomegranate cultivars reflects variations in anthocyanin composition. to identify genes involved in the regulation of anthocyanin biosynthesis pathway in the pomegranate fruit skin we have isolated, expressed and characterized the pomegranate homologue of the arabidopsis thaliana transparent testa glabra1 (ttg1), encoding a wd40-repeat protein ...201121643990
delphinidin, a specific inhibitor of histone acetyltransferase, suppresses inflammatory signaling via prevention of nf-+¦b acetylation in fibroblast-like synoviocyte mh7a cells.histone acetyltransferase (hat) inhibitors (hati) isolated from dietary compounds have been shown to suppress inflammatory signaling, which contributes to rheumatoid arthritis. here, we identified a novel hati in punica granatum l. known as delphinidin (dp). dp did not affect the activity of other epigenetic enzymes (histone deacetylase, histone methyltransferase, or sirtuin1). dp specifically inhibited the hat activities of p300/cbp. it also inhibited p65 acetylation in mh7a cells, a human rheu ...201121683061
in vitro antibacterial activity of some iranian medicinal plant extracts against helicobacter pylori.helicobacter pylori infection causes lifelong chronic gastritis, which can lead to peptic ulcer, mucosa-associated lymphoid tissue (malt) lymphoma and gastric cancer. the growing problem of antibiotic resistance by the organism demands the search for novel candidates from plant-based sources. in the present study, we evaluated the in vitro anti-h. pylori activity of some selected medicinal plants on clinical isolates of h. pylori. gastric biopsy samples were obtained from patients presenting wit ...201121726128
in vitro antimalarial activity and cytotoxicity of some selected cuban medicinal plants.terrestrial plants have been demonstrated to be sources of antimalarial compounds. in cuba, little is known about antimalarial potentials of plant species used as medicinals. for that reason, we evaluated the antimalarial activity of 14 plant species used in cuba as antimalarial, antipyretic and/or antiparasitic. hydroalcoholic extracts were prepared and tested in vitro for the antimalarial activity against plasmodium falciparum ghana strain and over human cell line mrc-5 to determine cytotoxici ...201021748227
cardioprotective potential of punica granatum extract in isoproterenol-induced myocardial infarction in wistar rats.to determine the protective role of punica granatum l. (punicaceae) seed juice extract and its butanolic fraction on heart rate, electrocardiographic patterns, vascular reactivity to catecholamines, cardiac marker enzymes, antioxidant enzymes together with morphologic and histopathological changes in isoproterenol-induced myocardial infarction in male wistar rats.201021808588
the antioxidant potency of punica granatum l. fruit peel reduces cell proliferation and induces apoptosis on breast cancer.pomegranate (punica granatum l.) is known to possess pharmacological activities, such as antioxidant and anticancer. in this study, we evaluated the antioxidant potency of a methanolic pomegranate fruit peel extract (ppe) and the relation with its antiproliferative and apoptotic effects on mcf-7 human breast cancer cells. total phenolic content and antioxidant activity of ppe were determined using the folin-ciocalteau and the 2,2-diphenyl-l-picrylhydrazyl free radical methods, respectively. phen ...201121861726
inhibitory effect of pomegranate on intestinal sodium dependent glucose uptake.intestinal glucose uptake is mainly performed by its specific transporters, sglt1 and gluts expressed in the intestinal epithelial cells. by using caco-2 cells and 2-nbdg, we observed that intestinal glucose uptake was markedly inhibited by pomegranate (punica granatum l, pg) among 200 screened edible korean plants. the effects of the pg extract on na(+)-dependent glucose uptake were further evaluated using brush border membrane vesicles (bbmv) obtained from the mouse small intestine. pg inhibit ...201121905289
new records of eriophyoid mites (acari: prostigmata: eriophyoidea) from saudi arabia.a field study was conducted to investigate eriophyoid mites associated with some fruit trees in riyadh, saudi arabia. the survey was carried out in four localities (el-waseel, al-beer, al-haiyer and el-deriya) and included seven species of fruit trees, namely olives (olea europea), fig (ficus carica), grapes (vitis vinifera), apple (malus domestica), citrus (citrus spp.), pomegranate (punica granatum) and pear (pyrus communis). seven new records of eriophyoid species (aceria benghalensis soliman ...201121916261
Antibacterial and antifungal activities of punica granatum peel extracts against oral pathogens.Punica granatum has been used for many years in folk medicine due to several purposes. The aim of the present study was to evaluate the effect of methanolic extract of Punica granatum peel (MEPGP) against Streptococcus mutans, Staphylococcus aureus, Streptococcus salivarius, Streptococcus sanguinis, Staphylococcus epidermidis, Actynomyces viscosus, Lactobacillus acidophilus and Candida albicans.201121998800
pharmacological investigations of punica granatum in glycerol-induced acute renal failure in rats.the present study was designed to investigate the ameliorative potential and possible mechanism of hydroalcoholic extract of flowers of p. granatum in glycerol-induced acute renal failure (arf) in rats.201122021999
computer aided screening and evaluation of herbal therapeutics against mrsa infections.methicillin resistant staphylococcus aureus (mrsa), a pathogenic bacterium that causes life threatening outbreaks such as community-onset and nosocomial infections has emerged as 'superbug'. the organism developed resistance to all classes of antibiotics including the best known vancomycin (vrsa). hence, there is a need to develop new therapeutic agents. this study mainly evaluates the potential use of botanicals against mrsa infections. computer aided design is an initial platform to screen nov ...201122125390
synergistic antioxidant activity of green tea with some herbs.cardiovascular diseases, cancer, arthritis, etc. are caused by free radicals that are byproducts of metabolic pathways. selected plants namely vitis vinifera, phyllanthus emblica l., punica granatum, cinnamomum cassia, ginkgo biloba l., and camellia sinensis linn. are reported to produce antioxidant property. this study is undertaken to support the hypothesis that formulation of a polyherbal combination of these plants shows a synergistic effect with green tea. the extracts of each drug were cha ...201122171315
pomegranate (punica granatum l.) flower improves learning and memory performances impaired by diabetes mellitus in rats.oxidative stress induced by diabetes mellitus leads to damages in the brain, as a consequence of which cognitive functions is impaired. therefore, for the treatment of diabetes mellitus, in addition to antidiabetics, antioxidants are used to cope with oxidative stress. the antioxidant ability of pomegranate flowers (pgf) to cope with the oxidative stress was investigated. rats were divided into five groups with 12 animals in each group as given below: control, diabetes (stz), stz + the pgf i (30 ...201122173022
pomegranate fruit extract inhibits uvb-induced inflammation and proliferation by modulating nf-κb and mapk signaling pathways in mouse skin(†).there is considerable interest in the identification of natural agents capable of affording protection to skin from the adverse effects of solar ultraviolet b (uvb) radiation. pomegranate (punica granatum l.) fruit possesses as strong antioxidant, anti-inflammatory and antiproliferative properties. recently, we have shown that oral feeding of pomegranate fruit extract (pfe) to mice afforded substantial protection from the adverse effects of single uvb radiation via modulation in early biomarkers ...201122181855
phyto-inspired silica nanowires: characterization and application in lipase immobilization.silica nanostructures were phyto-fabricated on different surfaces by using pomegranate (punica granatum) leaf extracts. on zinc films, nanowires were obtained. on other surfaces such as silica, alumina, zinc oxide and glass, spherical aggregates, cubic assemblies, micro-flakes and acicular structures, respectively, were observed. the nanowires developed on zn surfaces were characterized by scanning electron microscope-energy dispersive spectrometer (sem-eds), x-ray diffraction (xrd), photolumin ...201122201456
ethnobotanical survey and antibacterial activity of plants used in the altiplane region of mexico for the treatment of oral cavity infections.the ethnobotanical survey conducted in this study showed 47 plant species used in the altiplane region of mexico for the treatment of dental diseases such as toothache, dental caries, periodontal disease and gingivitis.201222465591
partial identification of antifungal compounds from punica granatum peel extracts.aqueous extracts of pomegranate peels were assayed in vitro for their antifungal activity against six rot fungi that cause fruit and vegetable decay during storage. the growth rates of alternaria alternata , stemphylium botryosum , and fusarium spp. were significantly inhibited by the extracts. the growth rates were negatively correlated with the levels of total polyphenolic compounds in the extract and particularly with punicalagins, the major ellagitannins in pomegranate peels. ellagitannins w ...201222533815
thai ethnomedicinal plants as resistant modifying agents for combating acinetobacter baumannii infections.acinetobacter baumannii is well-recognized as an important nosocomial pathogen, however, due to their intrinsic resistance to several antibiotics, treatment options are limited. synergistic effects between antibiotics and medicinal plants, particularly their active components, have intensively been studied as alternative approaches.201222536985
the potential influence of plant-based feed supplements on sperm quantity and quality in livestock: a review.the reproductive performance of male livestock is of economic importance, and improving semen quantity and quality, especially for artificial insemination, additionally helps to avoid the loss of valuable genotypes. the review focuses on the impact of oxidative stress on sperm production and quality in livestock, and the potential role of plant based anti-oxidants to control this impact. from scientific reports dealing with livestock, the paper compiles evidence on effective dietary measures aff ...201222575847
pomegranate (punica granatum) peel is effective in a murine model of experimental cryptosporidium parvum.cryptosporidiosis, a major health issue for neonatal calves, is caused by the parasite cryptosporidium parvum, which is highly resistant to drug treatments. to date, many anti-parasitic drugs have been tested, but only a few have been shown to be partially effective in treating cryptosporidiosis. previous studies have indicated that pomegranate (punica granatum) possesses anti-plasmodium, anti-cestode, and anti-nematode activities. therefore, the aim of this study was to evaluate the effect of p ...201222580265
ephedra alte (joint pine): an invasive, problematic weedy species in forestry and fruit tree orchards in jordan.a field survey was carried out to record plant species climbed by ephedra alte in certain parts of jordan during 2008-2010. forty species of shrubs, ornamental, fruit, and forest trees belonging to 24 plant families suffered from the climbing habit of e. alte. growth of host plants was adversely affected by e. alte growth that extended over their vegetation. in addition to its possible competition for water and nutrients, the extensive growth it forms over host species prevents photosynthesis, s ...201222645486
hepatoprotective and antioxidant activity of standardized herbal extracts.phyllanthus emblica, camellia sinensis, mangifera indica, punica granatum, and acacia catechu have been shown to possess widespread pharmacological application against multitude of diseases namely cancer, diabetes, liver disorders, and oxidative stress.201222701284
report: studies on antibacterial activity of some traditional medicinal plants used in folk medicine.ethanolic extracts of eight medicinal plants commonly used in folk medicine were tested for their antibacterial activity against four gram positive strains (bacillus subtilis, staphylococcus aureus, staphylococcus epidermidis and, streptococcus pneumoniae) and six gram negative strains (escherichia coli, proteus vulgaris, proteus mirabilis. salmonella typhi para a, salmonella typhi para b and shigella dysenteriae) that were obtained from different pathological laboratories located in karachi, pa ...201222713958
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