Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| ultrastructure of normal monkey liver. | the normal ultrastructure of the liver of rhesus and cynomolgus monkeys is described. a classification of type a and b periportal hepatocytes is introduced together with a discussion of the high incidence of mitochondrial abnormalities. it is suggested that the rhesus monkey is more suitable as an experimental model than the cynomolgus since its liver ultrastructure is less variable. | 1979 | 113618 |
| macaca fascicularis: alternative epileptic model. | 1979 | 113638 | |
| dose-response relations for dicentric yields in go lymphocytes of man and crab-eating monkey following acute and chronic gamma-irradiations. | a comparison has been made of dicentric yields in go lymphocytes between man and crab-eating monkey, macaca fascicularis, after acute and chronic gamma-irradiations. with acute irradiation (49.6 rad/min) there was no significant difference between them, but for the chronic irradiation (17.1 rad/h) a significant difference was observed between the species. when the dose-response relations were fitted to the linear-quadratic model (y = alpha d + beta d2), the species-difference observed for chroni ... | 1979 | 113673 |
| an anatomical investigation of the corticopontaine projection in the primate (macaca fascicularis and saimiri sciureus)--ii. the projection from frontal and parental association areas. | 1979 | 113692 | |
| transmission of sarcocystis suihominis from humans to swine to nonhuman primates (pan troglodytes, macaca mulatta, macaca irus). | sporocysts of sarcocystis suihominis obtained from human feces were used to infect swine. heart, tongue, and skeletal muscle from experimentally infected and noninfected control swine were fed via stomach tube to nonhuman primates including chimpanzees (pan troglodytes), rhesus monkeys (macaca mulatta), and cynomolgus monkeys (macaca irus). all primates fed infected swine tissues shed sporocysts beginning 13 to 15 days postinfection and were still shedding sporocysts at the conclusion of the exp ... | 1979 | 113949 |
| alteration in bone marrow rna of vitamin e-deficient monkey, macaca fascicularis. | in anemic crab-eating monkeys, macaca fascicularis, there is an alteration in the bone marrow rna species resulting from early vitamin e deficiency, when compared with those from normal simian bone marrow or from phenylhydrazine-induced anemic bone marrow of rabbit. anemia of vitamin e deficiency is specifically associated with a reduction in the ribosomal rna content. | 1979 | 114044 |
| sarcocystis in man: a review and report of five cases. | sarcocystis was identified in biopsy specimens of skeletal muscle from two adults in singapore and one in bombay, and in muscle obtained at autopsy from an adult in uganda, and in the heart of a child in costa rica. review of case reports revealed that in seven reported cases, including three reported by lindemann, non-parasite objects were misinterpreted as sarcocysts; in four instances organisms of undetermined classification were described, and in 35 cases true sarcocysts were observed. among ... | 1979 | 114067 |
| the evoked cochlear mechanical response in laboratory primates. a preliminary report. | the evoked cochlear mechanical response has been recorded in two species of laboratory primates, macaca irus and erythrocebus patas. the responses are very similar to those obtained in humans although the response to each click is of shorter duration. the response is vulnerable to the ototoxicity of furosemide and etacrynic acid and to noise exposure. at and near threshold an active generator of mechanical energy within the cochlea is proposed. the significance of such a generator and a possible ... | 1979 | 114151 |
| organization of somatic thalamus in monkeys with and without section of dorsal spinal tracts. | in an attempt to understand the modifications which appears at the thalamic level when dorsal cord sections are performed, peripheral fields of thalamic units were studied in normal and dorsal-cord sectional monkeys, totally awake and implanted with glass micropipettes. six normal macaca cynomolgus and 7 having received spinal sections, were studied. ventricular radiography was performed and all the coordinates were related to new stereotaxic coordinates using the posterior commissure as the ori ... | 1979 | 114272 |
| [study on the distribution of methyl-mercury (203hg) by whole body autoradiography of macaque monkeys (macaca irus)]. | the distribution of methyl-mercury labelled with mercury-203 has been studied in monkeys by whole body autoradiography technique. the mercury is rapidly absorbed. it is localized in all the body and mainly in well defined areas of the central nervous system. | 1978 | 114318 |
| regional cerebral blood flow thresholds during cerebral ischemia. | the development of methods of determining regional cerebral blood flow (rcbf) has made possible the determination of thresholds for the appearance of cerebral ischemia. these thresholds vary depending on the method used for assessing cerebral ischemia. the following thresholds have been determined in man and nonhuman primates: 20 cc/100 g per min, electroencephalogram (eeg) and evoked cortical potential abnormalities appear, paralysis seen in waking monkeys; 15 cc/100 g per min. eeg and evoked c ... | 1979 | 114427 |
| in vitro interaction between normal cynolmolgus monkey alveolar macrophages and legionnaires disease bacteria. | the interaction between normal cynomolgus monkey alveolar macrophages and legionnaires disease bacteria was studied by transmission electron microscopy. after ingestion of legionnaires disease bacteria, the organisms replicated within macrophages and destroyed the phagocytic cell. | 1979 | 114492 |
| experimental degeneration of primary afferent terminals in the cuneate nucleus of the monkey (macaca fascicularis). | six monkeys (macaca fascicularis) were used for the present study. in animals which survived for 2-6 days after section of c5 to t1 dorsal roots, at least four types of degenerating afferent terminal were observed - electron-dense, electron-lucent, neurofilamentous and flocculent. the electron-dense degeneration was the most common and was seen as early as 2 days after rhizotomy. the neurofilamentous type was the second commonest and was found predominantly in the 3 days' survival material. the ... | 1979 | 114509 |
| the distribution of oxytocin- and neurophysin-stained fibers in the spinal cord of the rat and monkey. | immunohistochemical methods have been used to describe the distribution of neurophysin i- and oxytocin-stained fibers in the spinal cord. in albino rats of either sex, such fibers descend through the dorsal part of the lateral funiculus to the caudal end of the cord. fibers leave the lateral funiculus to innervate the marginal zone of the dorsal horn at all levels, and the intermediolateral column at thoracic, lumbar and sacral levels. some fibers course medially through the intermediate gray to ... | 1979 | 115910 |
| seasonal variation of reproductive parameters in the laboratory-housed male cynomologus macaque (macaca fascicularis). | changes in body weight, sperm concentration and testicular volume were monitored for a 13-lunar month period in seven laboratory-housed adult male macaca fascicularis. no significant change was noted in body weight or sperm concentration between periods of maximal and minimal mean values nor between periods standardized for comparison between the three parameters. testis volumes were significantly greater during the months of july through early september and during the standardized period of may ... | 1999 | 116003 |
| multiple cannulation of the primate superficial lateral coccygeal vein. | the superficial lateral coccygeal veins of macaca fascicularis were exposed surgically and cannulated with polyethylene tubing. the cannula was used for administering continuous infusions or obtaining multiple blood samples, and it was removed 12--18 hours after insertion. | 1979 | 116074 |
| surveys of simian malaria in japan. | the survey of simian malaria in japan which had been conducted since 1965 showed that no japanese monkeys (macaca fuscata fuscata and macaca fuscata yakui) were infected with malaria parasites. most interestingly, however, babesia sp. was found in 4 (4.3%) of 93 macaca fuscata yakui which had been reared in a monkey park. as for the monkeys imported from abroad, plasmodium was only found in macaca irus from southeast asia, namely, p. inui (14.1-25.0%), p. cynomologi (0.6, 3.2%) and p. coatneyi ( ... | 1979 | 116437 |
| anaphylaxis in the monkey: hemodynamics and blood flow distribution. | aggregate anaphylaxis was induced in eight ovalbumin-sensitized monkeys (macaca irus). hemodynamics, blood flow distribution and myocardial performance were studied. following challenge, severe circulatory shock developed. systemic arterial and left atrial pressures decreased and pulmonary arterial and right atrial pressures increased. there was a tenfold increase in pulmonary vascular resistance, and cardiac output was markedly reduced (-75%). a redistribution of the blood flow to vital organs ... | 1979 | 116476 |
| schistosoma mansoni: immunization of cynomolgus monkeys by injection of irradiated schistosomula. | 1979 | 116865 | |
| temporomandibular joint meniscectomy--effects on joint structure and masticatory function in macaca fascicularis. | the postoperative effects of unilateral temporomandibular joint meniscectomy on joint structure and masticatory function were evaluated in four mature macaca fascicularis and compared with one control. mandibular movement during mastication was monitored objectively with an optoelectronic tracking system within four months and again within twelve months postmeniscectomy in each animal. temporomandibular joint structure was documented radiographically and histologically. results showed that degen ... | 2002 | 117065 |
| effects of oral and intramuscular carbaryl administrations on repeated chain acquisition in monkeys. | a type of learning task was utilized to determine the effective dose of carbaryl on macaca fascicularis for both oral and in routes of administration. monkeys were required to press four buttons in a set order; the order was changed daily. a baseline reversal design was utilized to test all animals several times at each concentration. the im carbaryl injections resulted in consistent, statistically reliable decrements in total session time and increases in errors at 5 and 10 mg/kg for the 4 anim ... | 1979 | 117115 |
| paragonimus westermani infection in a cynomolgus monkey. | 1979 | 118146 | |
| radioimmunoassay of class-specific antibodies to streptococcus mutans in monkey serum and saliva. | a radioimmunoassay (ria) has been developed to measure class-specific antibodies to steptococcus mutans in the serum and saliva of monkeys (macaca fascicularis). anti-human immunoglobulin antibodies purified by affinity chromatography on immobilised monkey immunoglobulins and labelled with 125i were employed. formolised cells of s. mutans and an extract of culture supernatant adsorbed to polystyrene wells were used as solid-phase antigens. the coefficients of variation for igg, iga and igm assay ... | 1979 | 118218 |
| treatment of subarachnoid hemorrhage with sodium nitroprusside and phenylephrine: an experimental study. | the effectiveness of simultaneous intravenous sodium nitroprusside and phenylephrine in improving the cerebrovascular disturbances and survival rate after induced subarachnoid hemorrhage (sah) was studied in the cynomolgus monkey. we measured regional cerebral blood flow (rcbf) using the intra-arterial xenon-133 clearance technique. in our experimental animal model, sah was associated with a persistent reduction in rcbf, elevation of cerebrovascular resistance (cvr), cerebral vasospasm for the d ... | 1979 | 118392 |
| [the effects of prostaglandin e1 on the lens of cynomolgus monkey (author's transl)]. | 1979 | 118663 | |
| branches of the aortic arch in the cynomolgus macaque (macaca fascicularis). | the aortic arch branching patterns of 49 male macaques (macaca fascicularis) were described and classified according to the classification systems of degaris, and the incidence of each pattern was determined. the most frequent pattern observed was a two-branch type in which a truncus communis of intermediate length (7 to 11 mm) and the left subclavian artery constituted the only aortic arch branches. five patterns not previously described in the cynomolgus were observed. comparison of the cynomo ... | 1979 | 118690 |
| suppression of pha-stimulated lymphocyte transformation in cynomolgus monkeys following infection with coxiella burnetii. | phytohemagglutin (pha) induced blastogenesis of peripheral blood lymphocytes from cynomolgus monkeys infected with c. burnetii was suppressed between 14 and 28 days after infection. lymphocytes became responsive to pha again on day 35 with an increase in stimulation index when cultured with specific antigens. in contrast, production of specific humoral antibodies was not diminished during the acute and early convalescent stages of infection. | 1979 | 118801 |
| mixed cell agglutination reaction of abo substances in the saliva and determination of human-type abo blood groups in the cynomolgus monkey. | for detection of abo substances in the saliva of the cynomolgus monkey, the mixed cell agglutination reaction (mcar) gave specific and clear results with a very small amount of saliva. anti-a and anti-b antibodies in the sera of the same species showed the clearest hemagglutination by the saline agglutination method. the combined use of both methods was demonstrated to be easily and accurately applicable to the determination of human-type abo blood groups of the cynomolgus monkey. | 1979 | 119081 |
| urinary cystic calculi in a cynomolgus monkey (macaca fascicularis): a case report. | an adult female macaca fascicularis monkey became acutely anorexic and depressed and was found dead approximately 24 hours later. necropsy revealed three hard brownish-yellow stones within the urinary bladder and urethra, a moderately shrunken left kidney, hemorrhage of the medulla of the left adrenal gland and a yellow liver. the stones, one of which was lodged in the urethra, were 1-2.5 cm in diameter, and their surfaces were rough and covered with spines. chemical analysis of the stones revea ... | 1979 | 119114 |
| acute toxicity of oral diquat (1,1'-ethylene-2,2'-bipyridinium) in cynomolgus monkeys. | 1979 | 119335 | |
| [parasitic fauna of the rhesus monkey (macaca mulatta) and of the (macaca irus)]. | 1979 | 119389 | |
| comparative effects of repeated and prolonged inhalation exposure of beagle dogs and cynomolgus monkeys to anaesthetic and subanaesthetic concentrations of enflurane and halothane. | male and female beagle dogs and cynomolgus monkeys were exposed to anaesthetic (1.5 mac) and subanaesthetic (1/100 mac) levels of enflurane and halothane for 3 hours on alternate days for 4 weeks. one-half of the animals were killed following the last exposure and the remainder after 4 weeks of recovery. the animals' condition was assessed during anaesthetic periods by measuring respiration, ecg, blood pressure, temperature and eeg. haematology, urinalysis and clinical chemistry parameters were ... | 1979 | 119420 |
| animal models for an integrated approach to the pharmacologic control of atherosclerosis. | a system of animal models potentially useful for the discovery and evaluation of new effective antiatherosclerotic agents is described. the models consist of a series of lipoprotein and atherosclerosis assays in rats, sea japanese quail and cynomolgus monkeys. sea quail are particularly useful for detecting compounds that inhibit arterial cholesterol deposition. the use of this integrated system of models is illustrated with data on clofibrate, adamantyloxyaniline (a hypobetalipoproteinemic agen ... | 1979 | 120168 |
| immunological cross-reactivity and sequence homology between salivary proline-rich proteins in human and macque monkey (macaca fascicularis) parotid saliva. | 1979 | 120171 | |
| an in vivo strain-gauge analysis of the squamosal-dentary joint reaction force during mastication and incisal biting in macaca mulatta and macaca fascicularis. | 1979 | 120172 | |
| the toxicity and renal handling of paraquat in cynomolgus monkeys. | the acute intravenous and oral toxicity of single doses of paraquat dichloride was studied in the cynomolgus monkey. renal handling and effects upon renal function were also investigated following an oral dose of [14c]paraquat. clinical signs consisted of vomiting, anorexia and dyspnoea. by 48 h all animals showed signs of acute renal failure with oliguria, high plasma urea and sgpt levels and metabolic acidosis. animals dosed orally showed similar, though less severe, signs to those dosed intra ... | 1979 | 120623 |
| evaluation of a killed rocky mountain spotted fever vaccine in cynomolgus monkeys. | a nonhuman primate model of rocky mountain spotted fever infection was developed in cynomolgus monkeys (macaca fascicularis) infected by the subcutaneous route or by aerosol. clinical responses, hematology and serum chemistry values, and pathological findings were similar to those found in humans ill with rocky mountain spotted fever. the clinical model was then used to test the efficacy of a killed rocky mountain spotted fever vaccine grown in chicken embryo cells. monkeys were immunized with v ... | 1979 | 120877 |
| comparison of experimental rickettsia tsutsugamushi infections in silvered leaf (presbytis cristatus) and cynomolgus (macaca fascicularis) monkeys. | both silvered leaf and cynomolgus monkeys were infected with the gilliam, karp and kato strains of rickettsia tsutsugamushi. the two species developed similar clinical syndromes, but the antibody responses were greater in cynomolgus monkeys. in both species of monkeys, the gilliam strain induced more severe clinical manifestations. at 10 months post-infection, silvered leaf monkeys were immune to homologous intradermal (id) challenge. cynomolgus monkeys, at 15 months post-infection, were relativ ... | 1979 | 120902 |
| observations on the lateral geniculate nucleus of the monkey (macaca fascicularis) after eye removal: a light and electron microscopic study. i. classification and degeneration of optic fibre terminals. | the morphological signs of terminal degeneration are compared at the light and electron microscopic levels in the lateral geniculate nucleus of macaca fascicularis, from 29 hours to 10 days after eye removal. a close correlation can be found between the appearance of degenerating rlp-terminals (i.e. large terminals containing round vesicles and pale mitochondria), which display marked, unorganized neurofilamentous hyperplasia, and the club-shaped structures revealed by neurofibrillary staning. t ... | 1979 | 121133 |
| the transfer of mesial drift potential along the dental arch in macaca irus: an experimental study of tooth migration rate related to the horizontal vectors of occlusal forces. | 1979 | 121286 | |
| biologic adaptability of extraoral forces to the maxilla of macaca irus. | 1979 | 121312 | |
| [characteristics of sepiapterin reductase from monkey (macaca fascicularis) liver (author's transl)]. | 1979 | 121552 | |
| [size of the foramen gubernaculare in the deciduous articulation in macaca fascicularis (author's transl)]. | 1979 | 121553 | |
| the morphology of follicular development and ovulation in non-human primates. | a colony of macaca fascicularis have been under continuous observation for the past 4 years to ascertain the follicular morphological changes that occur prior to ovulation and during the development of the corpus luteum. of 609 experimental cycles, laparoscopy was performed at least once in 44-5% of the cycles. of the 104 cycles where the ovulatory status was definitely known, 89-4% were deemed ovulatory and 10-6% anovulatory. the presence or absence of ovulation in the previous cycle did not ha ... | 1975 | 127041 |
| [adrenosympathetic system and thermoregulation in a prosimian perodicticus potto]. | the urinary excretion of catecholamines in perodicticus potto (1.76-2.94 mug/kg 24 h) is in the same range as in other mammals and the activity of the adrenosympathetic system does not account for the low metabolic rate in this species. the adrenals contain 1.140 +/- 0.14 mug a + na/mg fresh tissue, of which adrenaline constitutes 94.5 per cent and are thus practically identical to those in macaca irus. in a cold environment the daily urinary excretion of catecholamines of the tropical but cold ... | 1975 | 129219 |
| role of hypertension in ischemic heart disease and cerebral vascular disease in the cynomolgus monkey with coarctation of the aorta. | the role of hypertension in cardiovascular disease was studied in the hypertensive coarcted monkey during the feeding of an atherogenic and nonatherogenic diet. during the 15-month period of observation, half of the hypertensive coarcted monkeys developed cardiovascular disease which included heart failure, ischemic heart disease, stroke, and sudden death. there were no cardiovascular complications in the control normotensive monkeys except for one cholesterol-fed animal. the incidence of ischem ... | 1977 | 140028 |
| muscle spindles in the inferior constrictor pharyngis muscle of the crab-eating monkey (macaca irus). | pharyngeal muscles were considered to be lacking in spindles. a search was made for the same in the inferior constrictor pharyngis muscle of the crab-eating monkey (macaca irus). muscle spindles were found for the first time in this muscle. transverse serial sections and teased preparations were obtained from this muscle belonging to six such animals, and these tissues were stained by masson's trichrome and ranvier's gold method, respectively. both the methods were successful in revealing these ... | 1978 | 143184 |
| reproductive performance in macaca fascicularis following repeated laparoscopy. | mating trials were conducted with 16 adult female m. fascicularis that had been repeatedly laparoscoped. eight of the females in this study conceived. of these, six delivered live full-term infants after having had between 38 and 67 laparoscopies prior to conception. | 2002 | 152356 |
| multifollicular papilliferous cystadenoma in a cynomolgus monkey (macaca fascicularis). | 1978 | 152357 | |
| comparative effects of cetaben (phb) and dichlormethylene diphosphonate (cl2mdp) on the development of atherosclerosis in the cynomolgus monkey. | 1978 | 152632 | |
| occurrence of a muscle spindle in the anterior digastric muscle of a monkey (macaca fascicularis). | 1979 | 161499 | |
| a comparative study on the presence of c-type viral particles in placentas from primates and other animals. | c-type particles are found in human, baboon, marmoset, rhesus, patas, and cynomolgus monkeys. a cebus monkey and two chimpanzee placentas have failed thus far to show the presence of these particles. of the nonprimate tissues examined one mouse and one guinea pig placenta were positive whereas a rabbit placenta was negative. variations in number of particles present in tissues as well as number of animals of a given species containing particles are noted. the isolation of foamyviruses from place ... | 1975 | 169817 |
| isolation of foamy virus from rhesus, african green and cynomolgus monkey leukocytes. | foamy virus (fv) was recovered regularly from the leukocyte of rhesus and cynomolgus monkeys and somewhat less often from african green monkey leukocytes. virus was found in virtually all organs of experimentally infected rhesus monkeys. no illness or pathologic abnormalities were noted in these animals or in any of the naturally infected animals in spite of the prolonged period of viral persistence in various organs and tissues. | 1975 | 171409 |
| diaphragmatic herniation of the liver in macaques demonstrated by intravenous hepatography. | a suspected diagnosis of diaphragmatic herniation of the liver in 2 monkeys (macaca fascicularis and macaca mulatta) was confirmed radiographically by using various contrast media. experimental compound ag 60.99, which is selectively concentrated in the liver and spleen, allowed excellent visualization of these 2 organs and confirmed the presence of a portion of the liver in the right thorax. cholografin meglumine was subsequently utilized to determine the location of the gall bladder. other pot ... | 1975 | 173919 |
| the pathogenesis of simian varicella virus in cynomolgus monkeys. | the mlm herpesvirus is infectious for cynomolgus monkeys. the disease in this species, possibly modulated by preinoculation antibody resembles human varicella. virus has been recovered from blood during the early incubation period, and from liver, lymph nodes, kidney, bladder and urine during the eruptive period of infection. the major target organs were skin and liver; specific pathological changes developed in both. appropriate antibody responses, including those to herpesvirus varicellae foll ... | 1975 | 174129 |
| pathogenesis of machupo virus infection in primates. | experimental machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. cumulative mortality during the two phases was 80% and 95% respectively. attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys. | 1975 | 182402 |
| protection of monkeys against machupo virus by the passive administration of bolivian haemorrhagic fever immunoglobulin (human origin). | bolivian haemorrhagic fever immunoglobulin of human origin, given either prior to or shortly after experimental infection with machupo virus, protected rhesus and cynomolgus monkeys against initial clinical illness. some survivors developed severe neurological signs 30-47 days after virus inoculation and died 4-6 days later. results from one of the experiments suggested that the development of neurological signs was associated more frequently with high doses of immunoglobulin than with intermedi ... | 1975 | 182406 |
| studies on the interaction between coxsackievirus a9 and hela cells. i. plaque-forming ability of coxsackievirus a9 in hela cell cultures. | most of the coxsackievirus a9 (ca 9 virus) including the prototype strain formed plaques in hela cell monolayers under agar overlay, although they showed little or no cytopathogenicity under fluid medium. these viruses were isolated or passaged in primary cynomolgus monkey kidney (mk) cell cultures, and the infectivity of any strain in terms of plaque-forming units was much higher in mk cells than in hela cells, even after plaque purification of the virus in hela cell cultures. ca 9 virus contai ... | 1976 | 184325 |
| monkeypox-specific antibodies in human and simian sera from the ivory coast and nigeria. | a test for monkeypox-specific antibodies is described. monkeypox immune sera can be made type-specific by immunoabsorption with heterotypic poxvirus extracts. monkeypox-specific antibodies were demonstrated in sera from 9 cynomolgus monkeys (macaca fascicularis) that had previously been experimentally infected with monkeypox. monkeypox-specific antibodies were found in 3 wild-caught african monkeys (cercopithecus spp.) and in 3 human sera collected from africans in the ivory coast and nigeria 3( ... | 1976 | 186210 |
| an overview of the biochemical pharmacology of probucol. | probucol was effective in lowering serum total cholesterol in mice at dietary livels as low as 0.0075%. it was also effective after a single 100 mg/kg i.v. dose in mice. the incorporation of acetate-(14)c into liver lipids of rats and mice was not significantly affected by probucol, although the results, especially in mice, make it impossible to rule out such an effect. cholesterol absorption was estimated in rats using a dual isotope technique. the observed reductions were not statistically sig ... | 1977 | 189154 |
| characterization of plasma low density lipoproteins on nonhuman primates fed dietary cholesterol. | ldl from animals of three nonhuman primate species, macaca mulatta, macaca fascicularis, and cercopithecus aethiops, were studied. a standard preparation of 125i-ldl was added to isolated lipoprotein mixtures just prior to separation of plasma lipoproteins by agarose gel chromatography. a relative size index, ri, was determined by dividing the elution volume of the iodinated ldl by the elution volume of the sample ldl, both volumes being determined simultaneously during chromatographic elution. ... | 1997 | 191551 |
| clinical and pathogenetic studies of medical lake macaque virus infections in cynomolgus monkeys (simian varicella). | the medical lake macaque (mlm) virus produced varicelliform eruptions in cynomolgus monkeys. not all experimentally infected monkeys developed overt disease; viremia was found, and specific antibodies were detected. specific lesions were found in skin, lymph nodes, and spleen. focal inflammatory lesions were present in liver, pancreas, and lung (after intratracheal instillation of virus). mlm virus was recovered from these and other organs. the temporal movements of mlm virus in and out of prima ... | 1977 | 192806 |
| comparison of primary rhesus and cynomolgus monkey kidney cell cultures for viral isolation from clinical specimens. | rhesus monkey kidney and cynomolgus monkey kidney cell cultures were compared for viral isolation by using clinical specimens that yielded 203 viral isolates. cynomolgus and rhesus monkey kidney cells were comparable for the isolation of 22 adenoviruses, 12 coxsackieviruses, and one poliovirus. four of 50 echoviruses and seven of ten herpesviruses were detected only in cynomolgus monkey kidney cells. influenza virus was isolated in 84 instances, of which eight were detected only in rhesus and fo ... | 1977 | 195459 |
| neurovirulence in cynomolgus monkeys of enterovirus 71 isolated from a patient with hand, foot and mouth disease. | six cynomolgus monkeys were inoculated subcutaneously with enteroviurs 71 (e71), isolated from the stools of a patient with hand, foot and mouth disease (hfmd). clinical symptoms were observed in three of the six monkeys. one monkey showed complete paralysis of the lower extremities and two animals showed weakness in the hind limbs 4 to 7 days after inoculation. lesions were found in the central nervous system (cns) of all monkeys. mild to moderate vascular lesions, perivascular cuffings, degene ... | 1978 | 205198 |
| diarrhea in newborn cynomologus monkeys infected with human rotavirus. | of six newborn cynomolgus monkeys (macaca fascicularis) naturally delivered and normally nursed five developed diarrhea after oral administration of human rotavirus. virus excretion was observed in the stool of four animals. this virus was transmitted to four out of six other monkeys causing diarrhea in only one animal. | 1978 | 206515 |
| selected animal models for systematic antiatherosclerotic drug development. | we have developed an integrated system for antiatherosclerosis drug development utilizing rats, sea quail, and cynomolgus monkeys as animal models. in general, the way the system is presently functioning is that thousands of compounds per year are randomly screened for hypobeta- or hyperalphalipoproteinemic activity in rats, and hundreds of compounds per year are screened in sea quail for antiatherosclerotic and hypocholesterolaric activity. a few selected compounds that have activity in both ra ... | 1978 | 215005 |
| male--female variability in the dietary cholesterol-induced hyperlipoproteinemia of cynomolgus monkeys (macaca fascicularis). | the characteristics of dietary cholesterol-induced hyperlipoproteinemia were studied in adult macaca fascicularis to determine if significant male--female differences could be identified. the plasma lipoproteins from individual animals were separated by agarose column chromatography and the resulting size populations of lipoproteins were chemically characterized. the distribution of constituents among the lipoprotein classes was determined. the lipoproteins that increased most significantly in r ... | 1978 | 215687 |
| studies on the progression and regression of coronary and peripheral atherosclerosis in the cynomolgus monkey. i. effects of dipyridamole and aspirin. | 1979 | 217724 | |
| studies on the structure of low density lipoproteins isolated from macaca fascicularis fed an atherogenic diet. | cynomolgus monkeys, macaca fascicularis, fed cholesterol-containing saturated-fat diets develop increased levels of high molecular weight plasma low density lipoproteins (ldl), associated with accelerated atherosclerosis. to study the composition and structure of these abnormal particles, ldl from monkeys, fed atherogenic and control diets, were characterized chemically and examined by differential scanning calorimetry and low-angle x-ray scattering. ldl from animals on the experimental diet sho ... | 1978 | 219029 |
| comparison of cynomolgus and rhesus monkey kidney cells for recovery of viruses from clinical specimens. | in a study of virus recovery from clinical specimens, cynomolgus monkey kidney cells demonstrated sensitivity equivalent or slightly superior to rhesus kidney cells for siolation of myxo- and paramyxoviruses, adenoviruses, and enteroviruses. | 1979 | 222808 |
| comparison of different tissue cultures for isolation and quantitation of influenza and parainfluenza viruses. | rhesus and cynomolgus monkey kidney tissue cultures and two continuous lines, madin-darby canine kidney (mdck) and llc-mk2, were compared in titrations and isolations of influenza and parainfluenza viruses. tube cultures were inoculated with laboratory virus strains or stored patient specimens and observed for hemadsorption. trypsin was added to the medium of the continuous lines to increase sensitivity. all four tissue cultures gave similar titers of influenza a/ussr (h1n1), a/texas (h3n2), and ... | 1979 | 227920 |
| [immunohistochemical study of the adenohypophysis of the monkey macaca irus with the use of antibodies anti 1-24-acth, anti 17-39-acth, anti alpha-and beta-endorphins, anti beta-lpm]. | indirect immunofluorescence technique with anti1-24- and anti17-39 acth, anti alpha- and anti beta-endorphins, anti beta-lph sera has allowed us to detect a cellular type in the anterior lobe of the hypophysis of macacus irus which react simultaneously with these five antisera. these cells are especially localized in the ventro-medial zone, but there are also present in the pars distalis, under the glandular capsule, and in the lateral lobes, amid the other cellular types. the cells of the inter ... | 1979 | 231476 |
| the application of qae-sephadex for the purification of two staphylococcal enterotoxins. i. purification of enterotoxin c2. | a new method developed for purification of enterotoxin c2 from staphylococcus aureus strain 361 consisted of four steps: batchwise adsorption from culture supernatant on qae-sephadex; gel filtration on sephadex g-100; chromatography on qae-sephadex using a buffer of constant ph and molarity; and gel filtration using a volatile buffer of constant ph and molarity; and gel filtration using a volatile buffer as the eluting solvent. the purified enterotoxin appeared homogeneous by gel immunodiffusion ... | 1975 | 237564 |
| regional gastric blood flow in cynomolgus monkeys with hemorrhagic shock and resuscitation. | five anesthetized cynomolgus monkeys were subjected to hemorrhagic shock (42 +/- 3 mm hg) for four hours and then resuscitated with shed blood and intravenous fluids to restore mean arterial pressure and arterial ph to control levels. regional gastric blood flow was measured by radioactive microspheres. responses were similar in all regions, except mucosal blood flow increased significantly (from 20.1 +/- 5.1 to 42.1 +/- 7.6 ml/min 100 gm of tissue) in response to resuscitation in the antrum but ... | 1978 | 262076 |
| mandibular joint control of genioglossus muscle activity in the cat (felis domesticus) and monkey (macaca irus). | 1978 | 299016 | |
| operant conditioning of infant monkeys (macaca fascicularis) for toxicity testing. | a technique has been developed that allows infant monkeys to perform on an operant schedule as soon as they are able to self-feed. behavior is shaped in small increments through a series of operants; sensory and motor systems as well as performance on schedules using intermittent reinforcement may be tested as early as 3-4 weeks of age. this is accomplished by exposing the infant to the operant situation almost continuously, and allowing the infant to feed only by operantly responding. infants e ... | 1979 | 299586 |
| factors influencing nursing in macaca fascicularis. | nursing by two mother-infant pairs in a caged colony of macaca fascicularis was monitored at 1-min intervals for 8 h beginning 8:30 a.m. bst, once a week for 3 months in the summer of 1973. nursing occupied about 210 min in 8 daylight hours for the infants at 10 weeks of age, and the time spent nursing decreased at the average rate of 9.4 min per week until the infants were about 6 months old. the time spent nursing by the infants studied here resembles closely the times spent nursing by some ot ... | 1977 | 401755 |
| cytochalasin b reversibly increases outflow facility in the eye of the cynomolgus monkey. | in cynomolgus monkeys, intracameral infusion of 0.2 to 5.0 mug of cytochalasin b caused an increase in outflow facility, as measured by two-level constant pressure perfusion. cytochalasin b had its full effect in eyes which had undergone surgical disinsertion of the ciliary muscle from the scleral spur, and were therefore insensitive to pilocarpine. the cytochalasin effect was apparent in less than 20 min. and was largely reversible over a few hours. thirty to 50 days after the infusion, facilit ... | 1977 | 401776 |
| interferon induction in cynomolgus and rhesus monkey after repeated doses of a modified polyriboinosinic-polyribocytidylic acid complex. | serum interferon activity was determined in 12 cynomolgus and 12 rhesus monkeys injected intravenously once daily for 10 days with from 0.1 to 6.0 mg of a stabilized polyriboinosinic acid . polyribocytidylic acid complex per kg, composed of polyriboinosinic acid . polyribocytidylic acid, poly-1-lysine, and carboxymethylcellulose [poly(iclc)]. interferon activity was detected 2 h after the first injection, with maximum activity occurring 8 h after the second injection. a period of hyporesponsiven ... | 1977 | 402107 |
| pilocarpine-induced subsensitivity to carbachol and pilocarpine of ciliary muscle in vervet and cynomolgus monkeys. | vervet monkeys were given unilateral treatment for two weeks with one 2% pilocarpine eye drop three times daily between 8 a.m. and 6 p.m. (night interval 14h) and were then subjected to anterior chamber perfusion 20 mug pilocarpine intracamerally caused similar and substantial increases in outflow facility in both eyes. cynomolgus monkeys were unilaterally treated with continuous release of 33 mug/h of pilocarpine for 5-6 days. the facility response to 1 mg/kg pilocarpine iv was small or absent ... | 1977 | 402785 |
| dentofacial changes produced by extraoral forward force in the macaca irus. | eleven macaca irus monkeys with a mixed or a permanent dentition were used in a study of the possible effects of extraoral forward force on the growth of the dentofacial skeleton. an intermittent forward force of 300 gm. per side was applied, and the effects were analyzed by means of model casts, cephalometric radiographs, tetracycline bone marking, microradiographs, and histologic preparations. the results obtained were as follows: 1. an extraoral forward force caused significant changes in the ... | 1977 | 402814 |
| effect of intra-articular corticosteroid injections on primate cartilage. | an attempt was made to ascertain whether intra-articular corticosteroids exert a harmful effect on primate cartilage. the knee joints of 10 macaca irus monkeys were subjected to either one, two, or six injections of 20 mg methyl prednisolone or an equal number of control injections over a 12-week period. minor degenerative changes of many femoral condyles were shown by india ink staining and by a system of histochemical grading. changes in the joints injected with corticosteroid were not signifi ... | 1977 | 402890 |
| induction of subcapsular cataracts in cynomolgus monkeys by echothiophate. | sixteen eyes of 13 cynomolgus monkeys were treated topically twice daily with echothiophate iodide. the dosages were increased gradually over several weeks to plateau levels ranging from 125 to 500 mug daily. the opposite eyes of the ten unilaterally treated monkeys received a control solution (diluent) identical save for the absence of echothiophate. all 16 echothiophate-treated eyes developed posterior subcapsular cataracts and 15 developed anterior subcapsular cataracts. the lenses in all ten ... | 1977 | 402905 |
| light and electron microscopy of the anterior chamber angle structures following surgical disinsertion of the ciliary muscle in the cynomolgus monkey. | light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. anterior chamber perfusion to measure gross outflow facility had been performed one to nine times postoperatively. over most of the circumference in most eyes (1) the ciliary muscle had been retrodisplaced from the scleral spur and had reattached to the sclera more posteriorly ... | 1977 | 403150 |
| formation and drainage of aqueous humor following total iris removal and ciliary muscle disinsertion in the cynomolgus monkey. | aqueous humor formation (ahf), uveoscleral flow (u), gross outflow facility (cg), true facility of outflow from the anterior chamber (ct1), true facility of outflow from anterior chamber into the general circulation (ct2), and the pressure sensitivity of ahf (pseudofacility; cps) were determined in cynomologus monkey eyes which had undergone total iris removal or iris removal followed by ciliary muscle disinsertion. ahf was in the normal range in iridectomized-only eyes. ahf was present but redu ... | 1977 | 403151 |
| efferent connections of cortical, area 8 (frontal eye field) in macaca fascicularis. a reinvestigation using the autoradiographic technique. | the efferent projections from the cortical area 8 (frontal eye field) have been re-examined in four adult monkeys (macaca fascicularis) by injecting small amounts of h3-proline into the rostral bank of sulcus arcuatus and using the autoradiographic tracing technique. ipsilateral cortical projections could be traced into specific areas of the depths of sulcus principalis, sulcus temporalis superior and sulcus intraparietalis. label was found contralaterally in area 8. subcortical connections were ... | 1977 | 403205 |
| pulp changes after anterior mandibular subapical osteotomy in a primate model. | subapical osteotomy of the anterior mandible was carried out on 10 adult macaca irus monkeys with and without open bite. teeth were extracted at 8 weeks, 12 weeks, 24 weeks and 1 year after surgery and the pulps examined histologically. no normal pulps were found. progressive fibrosis and calcification was noted in all teeth. patent pulp blood vessels were found up to 24 weeks after surgery. pulp damage to teeth distal to the osteotomy site was found in 50% of cases. control teeth extracted from ... | 1977 | 403247 |
| orbital cortical influences on cardiovascular dynamics and myocardial structure in conscious monkeys. | the posterior orbital cortex of the frontal lobes in conscious monkeys was stimulated electrically to study the influence of this structure on cardiovascular hemodynamics and cardiac morphology. stimulating electrodes, cardiac output flow probes, and arterial blood pressure transducers were chronically implanted by aseptic procedures into eight macaca fascicularis monkeys. cardiovascular changes induced by stimulating the orbital cortex included both biphasic and unidirectional alterations in ca ... | 1977 | 403254 |
| [changes of the uterine size during pregnancy in cynomolgus monkeys (macaca fascicularis) (author's transl)]. | this paper describes changes in the uterine size during the normal course of pregnancy in cynomolgus monkeys. twenty-four females which had conceived by 3-day individual mating with a male were laparotomized 4,5,6,7,8,9,10,15 and 20 weeks after conception. the width, thickness and length of uterus were measured by a pair of callipers. them, the uterine volume was estimated by the formula, v = 4/3 piab2 (a, b: uterine length x 1/2, uterine width x 1/2). the increase in the uterine width (y) durin ... | 1977 | 404166 |
| administration of human interferon to rabies virus-infected monkeys after exposure. | the treatment of rabies-infected cynomolgus monkeys (macaca fascicularis) with human interferon after exposure was studied. the monkeys were infected with rabies street virus by the intramuscular route; larger than or equal to 24 hr after infection, human interferon was administered intramuscularly or by lumbar spinal injection into the cerebrospinal fluid. whereas 90% of the infected untreated monkeys died, 40%-80% of animals treated with interferon survived. no or only low levels of neutralizi ... | 1977 | 404370 |
| metabolism of thromboxane b2 in the cynomolgus monkey. | [5,6,8,9,11,12,14,15-3h8]-thromboxane b2 was injected into the saphenous vein of female cynomolgus monkeys, and blood samples were withdrawn from the contralateral saphenous vein. the compound was eliminated from the circulation with a half-life of about 10 min after an initial rapid disappearance. some more polar products appeared with time, and also small amounts of material less polar than thromboxane b2; however, the dominating compound in all blood samples was unconverted thromboxane b2. ab ... | 1977 | 404670 |
| trabeculo-electropuncture in cynomolgus monkeys (macaca irus). | trabeculo-electropuncture (tep) was performed in one eye of ten cynomolgus monkeys. in five control eyes, the tep probe was inserted into schlemm's canal and withdrawn without causing a spark discharge. in another five control eyes,a scleral window was produced and the canal was opened, but no probe was inserted. the gross facility of outflow was determined prior to the operation and 2, 6, and 18 weeks postoperatively. tep had no longlasting effect on the facility. gonioscopy five months after t ... | 1977 | 404932 |
| comparative studies of several vaccinia virus strains by intrathalamic inoculation into cynomolgus monkeys. | from the comparative studies of the virulence of several vaccinia virus strains by intrathalamic inoculation into cynomolgus monkeys, the following results were observed. the cv1 virus was most virulent, the new york city board of health, ikeda, em63, and lister viruses were slightly less virulent, and dis and lc16 viruses least virulent. the characteristic findings were widespread inflammatory lesions in the meninges and choroid plexus which were closely associated with the replication of vacci ... | 1977 | 404993 |
| absence of self-recognition in a monkey (macaca fascicularis) following prolonged exposure to a mirror. | to date only chimpanzees, orangutans, and humans have been found capable of recognizing themselves in mirrors. in an attempt to provide a more definitive test of the capacity for self-recognition in monkeys. i gave a preadolescent crab-eating macaque 2400 hr of mirror exposure. however, patterns of self-directed behavior never developed and a more explicit test of self-recognition yielded negative results. the data indicate possible differences between great apes and monkeys in self-awareness. | 1977 | 405264 |
| dicentric yields induced by gamma-radiation and chromosome arm number in primates. | to evaluate the effect of the chromosome arm number on the yield of dicentric chromosomes, frequencies of gamma-ray-induced chromosome aberrations were examined with peripheral lymphocytes from three different primate species, saimiri sciureus (arm number, 77), macaca fascicularis (arm number, 83) and nycticebus coucang (arm number, 99). irradiated blood samples were cultured by the same standard technique as that commonly used for human lymphocytes. the yields of dicentrics and dicentrics plus ... | 1977 | 405578 |
| biological effects of cocaine derivative ii: pharmacological evaluation of n-allyl norcocaine in cynomolgus monkeys. | 1977 | 405679 | |
| sulfated glycoproteins in the acquired pellicle and in plaque from macaca fascicularis demonstrated with labeled sulfate. | 1977 | 405736 | |
| endotoxic activities of lipopolysaccharides of microorganisms isolated from an infected root canal in macaca cynomolgus. | lipopolysaccharides (lps) prepared from a strain of bacteroides oralis, a strain of fusobacterium necrophorum, and a strain of f. nucleatum, all isolated from an infected root canal in monkey (macaca cynomolgus), were examined for endotoxic activities using primary skin reactions in rabbits and induction of leukocyte chemotaxis in rats. lps of b. oralis showed considerably lower ability to cause skin inflammation than lps of the fusobacteria. however, the leukotactic effect of the lps preparatio ... | 1977 | 405737 |
| heart rate in caged macaca fascicularis. effects of short-term physical exercise. | electrocardiograms were recorded hourly for five days in 16 caged macaca fascicularis by means of a miniaturized ecg transmitter connected to two chest leads. the lowest heart rates were 135 +/- 35 (mean +/- sd, n= 31) beats/min at 5 a.m., and the highest were 192 +/- 22 (n = 29) beats/min at 3 p.m. sinus arrhythmia was common. eight of the animals were trained to exercise in a specially designed enclosed treadmill; their heart rates were recorded daily during two 10-min periods of running at 3. ... | 1977 | 406403 |
| blood groups of crab-eating macaques (macaca fascicularis) demonstrated by isoimmune rhesus monkey (macaca mulatta) sera. | twenty-one isoimmune sera produced in rhesus monkey (macaca mulatta) containing type-specific antibodies for simian-type red cell antigens were tested for their cross-reactivity with red cells from crab-eating macaques (m. fascicularis). the majority of the antisera gave cross-reactions determining polymorphisms in the red cells of crab-eating macaques, homologous to those of rhesus monkeys. these results attest to the close taxonomic realationship between the two species of macaques, and have t ... | 1977 | 406404 |