Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| synergism of nbqx with dopamine agonists in the 6-ohda rat model of parkinson's disease. | advance in understanding of the anatomy, physiology and pharmacology of basal ganglia organisation over the past decade revealed a functional relation between excitatory glutamatergic and the degenerated dopaminergic nigrostriatal transmitter systems which could serve as targets for pharmacological interventions in parkinson's disease. the selective ampa-antagonist nbqx is not effective in animal models of parkinson's disease when given alone but ameliorates parkinsonian symptomatology and enhan ... | 1992 | 1491248 |
| polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 4. effects of multiple-dose treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on peripheral lymphocyte subpopulations of a non-human primate (callithrix jacchus). | non-human primates (callithrix jacchus) were treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) over a period of 30 weeks, and lymphocyte subpopulations of venous blood were monitored using monoclonal antibodies and flow cytometry (facscan). there was no clear-cut change in the total lymphocyte population during this study. in the first part of the study the new-world monkeys (marmosets) were treated for 24 weeks with a weekly dose of 0.3 ng tcdd/kg body wt. at the end of this treatment per ... | 1992 | 1514923 |
| the distribution of 5-ht3 recognition sites in the marmoset brain. | the distribution of the binding of [3h]gr65630 (0.2 nm) to putative 5-ht3 recognition sites in the brain of the common marmoset was assessed using autoradiography. specific binding was heterogeneously distributed with the highest densities found in discrete nuclei of the lower medulla (nucleus tractus solitarii, dorsal motor nucleus of the vagus nerve, nucleus of spinal trigeminal nerve tract and the area postrema). in forebrain areas, relatively high binding densities were located in the medial ... | 1992 | 1516650 |
| sex ratio and mortality in a laboratory colony of the common marmoset (callithrix jacchus). | in a retrospective study sex ratio and mortality were analysed in a captive colony of common marmosets (callithrix jacchus). seven hundred and thirty-five infants in 294 litters (20 singletons, 119 twins, 140 triplets, 14 quadruplets) out of 57 breeding females were evaluated. the sex ratio at birth was 0.95 males:1.0 females. the frequency of males and females, as well as the sex composition of twins and triplets confirm the assumption of dizygotic twinning in the common marmoset. according to ... | 1992 | 1518282 |
| karyotypic comparison among cebuella pygmaea, callithrix jacchus and c. emiliae (callitrichidae, primates) and its taxonomic implications. | the karyotype of cebuella pygmaea (2n = 44) obtained by g-, c-banding, and nor-staining is described. this species presents a heteromorphic c band in the intersticial region of the short arm of chromosome 2. the data obtained were compared with those previously described for the karyotypes of callithrix jacchus and callithrix emiliae. the three species differ in the amount and distribution of non-centromeric constitutive heterochromatin. the importance of the variation in constitutive heterochro ... | 1992 | 1521801 |
| behavioural effects of anxiogenic agents in the common marmoset. | the effects of the anxiogenic agents fg7142, caffeine, pentylenetetrazole, and amphetamine were assessed in two anxiety situations in the marmoset, first in an "anxiogenic" test based on the animal's response to a human observer standing in front of the home cage and second in a low-anxiety situation where animals behaviour was videotaped in the absence of the observer. in response to the human observer, the anxiolytic agent diazepam (0.1-2.5 mg/kg, sc) was shown to reduce the intensity of behav ... | 1992 | 1528937 |
| immunohistochemical localization of collagenous components in healthy periodontal tissues of the rat and marmoset (callithrix jacchus). i. distribution of collagen types i and iii. | the distribution of collagen types i and iii was demonstrated in healthy periodontal tissues of the rat and marmoset using immunofluorescent localization after decalcification of the maxillae and mandiblae in 0.2 n hcl. an intense fluorescence in the alveolar bone and cementum matrix, as well as in the soft periodontal tissue, was demonstrated with anti-collagen type i antibodies. in the gingival connective tissue and in the periodontal ligament thick fibers of collagen type i could be observed. ... | 1992 | 1532200 |
| the polymorphic photopigments of the marmoset: spectral tuning and genetic basis. | the marmoset (callithrix jacchus jacchus), a south american monkey, is polymorphic for the middle- to long-wave cone photopigments: the three variant pigments have spectral peaks at 543, 556 and 563 nm. comparisons of the deduced amino acid sequences of these pigments indicate that the variations in spectral sensitivity are associated with the presence or absence of hydroxyl-bearing residues at sites 180 and 285; but, in contrast to the additive hypothesis of neitz et al. (1991), we propose that ... | 1992 | 1534748 |
| corpus callosum in sexually dimorphic and nondimorphic primates. | the midsagittal area and other morphological measures were taken on the corpus callosum of four different species of primate: macaca mulatta, m. fascicularis, callithrix jacchus, and saguinus oedipus. the first two species are strongly dimorphic, whereas the new world forms show little dimorphism with regard to overall body size, canines, and brain weight. neither total corpus callosal area (totalcc), or other parts of the corpus callosum (cc) showed any significant sexual dimorphism in any of t ... | 1992 | 1562061 |
| analysis of the contraceptive potential of antibodies against native and deglycosylated porcine zp3 in vivo and in vitro. | we have undertaken a comparative analysis of the contraceptive activity of antibodies directed against the porcine sperm receptor zona pellucida antigen (zp3) and its mr = 32,000 polypeptide core (dgzp-32). the strategies employed for this analysis included the induction of active immunity in a primate, the common marmoset, and an in vitro fertilization protocol involving the use of viable human ova. in both experimental situations, antibodies against zp3 were shown to exhibit contraceptive acti ... | 1992 | 1576251 |
| influence of dexamethasone on the rm 3/1-positive macrophages in the peripheral blood and tissues of a new world monkey (the marmoset callithrix jacchus). | subcutaneous injection of the glucocorticoid dexamethasone in the primate callithrix jacchus increased the proportion of the macrophage subtype rm 3/1 in the blood from a basic level of 16% positive monocytes to about 65%. the elevated numbers of rm 3/1-positive cells were seen 24 and 72 h after application and were independent of the dosages used (50 or 150 micrograms/kg). oral administration had no effect. cd4-, cd14- and cdw14-antigen expression of monocytes was not influenced by the dexameth ... | 1992 | 1582709 |
| dietary lipid modulation of ventricular fibrillation threshold in the marmoset monkey. | programmed electrical stimulation was used to examine the ability of long-term dietary lipid modulation to influence myocardial vulnerability to the induction of ventricular fibrillation in adult marmoset monkeys (callithrix jacchus). marmosets fed diets supplemented (to a total of 28.5% of the energy as fat) with polyunsaturated fatty acid (pufa)-rich tuna fish oil or sunflower seed oil had significantly elevated mean ventricular fibrillation threshold compared with those fed a saturated animal ... | 1992 | 1595535 |
| the relationship between cone pigments and behavioural sensitivity in a new world monkey (callithrix jacchus jacchus). | microspectrophotometric measurements of visual pigments and behavioural measurements of spectral sensitivity are reported for individual marmosets from 3 family groups. the sex differences and polymorphism that characterise the long-wave cone pigments in this species are well reflected by variations in the behavioural sensitivities. with one exception, the pattern of inheritance is compatible with a genetic model in which the long-wave pigment is specified by a single polymorphic locus on the x- ... | 1992 | 1604855 |
| intercellular communication between cultured granulosa cells of the marmoset (callithrix jacchus). | the influence of follicle-stimulating hormone, forskolin, insulin-like growth factor type i, epidermal growth factor, and 12-tetradecanoyl-phorbol-13-acetate on marmoset granulosa cell communication via gap junctions was investigated by morphological means and microinjection of carboxyfluorescein. gap junctions between neighbouring granulosa cells were present in all groups. the number, but not length, of gap junctions between marmoset granulosa cells increased when the cells had been treated wi ... | 1992 | 1617703 |
| identification and characterization of the herpesvirus saimiri oncoprotein stp-c488. | the protein encoded by herpesvirus saimiri transforming gene stp-c488 was identified and characterized. antibodies were produced in rabbits by immunization with keyhole limpet hemocyanin-conjugated synthetic peptides specific for the predicted sequence of stp-c488. stp-c488-encoded protein was detected in recombinant escherichia coli, transformed rat-1 cells, transfected cos-1 cells, and in common marmoset t lymphocytes immortalized by herpesvirus saimiri strain 488. stp-c488 protein was sensiti ... | 1991 | 1658384 |
| the effect of dietary change on in vitro erythrocyte haemolysis, skin lesions and alopecia in common marmosets (callithrix jacchus). | 1. the effect of dietary change on common marmosets (callithrix jacchus) exhibiting high in vitro erythrocyte haemolysis, skin lesions and alopecia was investigated. 2. the experimental diet was low in lipid, high in vitamin e and was devoid of n-3 long chain polyunsaturated fatty acids. 3. there were significant increases in the concentrations of plasma alpha-tocopherol (vitamin e) (p less than 0.05), all-trans retinol (vitamin a) (p less than 0.001) and total lipid (p less than 0.025), and a r ... | 1991 | 1685382 |
| an enkephalin degrading aminopeptidase of human brain preserved during the vertebrate phylogeny. | 1. a soluble human brain aminopeptidase which hydrolyses the tyr-gly bond of met-enkephalin and leu-enkephalin was identified in the brains of the following vertebrates: mammals (callithrix jacchus and rattus norvegicus), bird (gallus domesticus), reptile (tupinambis teguixin), amphibia (bufo paracnemis), fish (sarotherdon niloticus) and elasmobranchy (galeocerdo cuvieri). 2. the properties of this enzyme are: molecular weight near 100,000 da, isoelectric point near 4.9, optimum ph near 7.5, act ... | 1991 | 1685408 |
| motor activity following the administration of selective d-1 and d-2 dopaminergic drugs to normal common marmosets. | in normal common marmosets administration of the d-1/d-2 agonist apomorphine or the selective d-2 agonist quinpirole caused a dose-dependent increase in motor activity and induced stereotyped behaviour. both the selective d-2 antagonist raclopride and the selective d-1 antagonist sch 23390 inhibited normal locomotor activity and induced catalepsy. quinpirole- and apomorphine-induced motor activity were potently inhibited by pretreatment with raclopride. the effects of quinpirole, but not apomorp ... | 1991 | 1686813 |
| development of a monoclonal antibody, anti-6c2, which is involved in the interaction of cd4 t helper cells and activated b cells. | we have developed a mab anti-6c2, by immunizing mice with t cell line derived from the callithrix jacchus (common marmoset). anti-6c2 is reactive with approximately 50% of unfractionated t cells, 50% of cd4+ cells, and 40% of cd8+ cells. regarding cd4+ cells, anti-6c2-reactive cells substantially overlap with the cd29+cd45ro+ th cell population. moreover, anti-6c2 can divide these t cells into 6c2+ and 6c2- subpopulations. the cd4+cd45ro+6c2+ cells maximally respond to soluble ag such as tetanus ... | 1991 | 1706389 |
| neurochemical and behavioural features induced by chronic low dose treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) in the common marmoset: implications for parkinson's disease? | protracted long-term treatment of common marmosets with 15 doses (0.5-4.5 mg/kg, i.p.) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; total dose 25 mg/kg, given over 29 days) caused transitory changes in motor behaviour reminiscent of human parkinson's disease. 16 days from the start of mptp administration, all animals showed motor impairment, consisting of profound akinesia and a rigid posture, but in no case resting tremor. biogenic amines were measured in nigrostriatal regions one mon ... | 1991 | 1712088 |
| topographical and topological organization of the thalamocortical projection to the striate and prestriate cortex in the marmoset (callithrix jacchus). | in eleven hemispheres of nine marmoset monkeys (callithrix jacchus), we have investigated the thalamo-cortical organization of the projections from the pulvinar to the striate and prestriate cortex. in each experiment, single or multiple injections of various retrograde fluorescent tracers were injected into adjacent regions or areas. in two experiments, horseradish peroxidase (hrp) was injected into the lateral geniculate nucleus (lgn) and the lateral pulvinar, respectively. the results show th ... | 1991 | 1712314 |
| the local domain for divergence of subcortical afferents to the striate and extrastriate visual cortex in the common marmoset (callithrix jacchus): a multiple labelling study. | in the common marmoset (callithrix jacchus), the cortical projection from the pulvinar and other diencephalic structures into the striate and prestriate cortex was investigated with various fluorescent retrograde tracers. single cortical injections as well as multiple injections at distances of 1-2 mm with one tracer into an extended but coherent cortical region were applied. fields with multiple injections were placed so that they touched each other (minimal distances 2 to 3 mm). retrogradely l ... | 1991 | 1712315 |
| isolation of an arenavirus from a marmoset with callitrichid hepatitis and its serologic association with disease. | callitrichid hepatitis (ch) is an acute, often fatal viral infection of new world primates from the family callitrichidae. the etiologic agent of ch is unknown. we report here the isolation of an arenavirus from a common marmoset (callithrix jacchus) with ch by using in vitro cultures of marmoset hepatocytes and vero-e6 cells. enveloped virions 67 to 133 nm in diameter with ribosomelike internal structures were seen in infected cultures. immunofluorescence and western immunoblot analysis using c ... | 1991 | 1712856 |
| immunohistochemical localization of collagenous components in healthy periodontal tissues of the rat and marmoset (callithrix jacchus). ii. distribution of collagen types iv, v and vi. | the immunohistochemical distribution of collagen types iv, v and vi has been demonstrated in healthy periodontal tissues of rats and marmosets following decalcification of the maxillae and mandibulae in 0.2 n hcl. an intense fluorescence with anti-collagen type iv antibodies was demonstrated in the basement membranes of the epithelium and of the blood vessels and nerves. in the alveolar bone stroma and in the periodontal ligament (pl) collagen type iv was present only in the basal membranes of t ... | 1991 | 1714953 |
| neuropeptide levels in the basal ganglia of aged common marmosets following prolonged treatment with mptp. | aged common marmosets were treated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; 0.5-2.0 mg/kg/week i.p.) for 16 or 24 weeks, observed for a total of 30 weeks and then killed for measurement of biochemical parameters in basal ganglia. the mptp treatment induced a marked depletion in dopamine, 3,4-dihydroxyphenylacetic acid and homovanillic acid levels in the caudate nucleus and putamen. in contrast, the concentrations of five neuropeptides: [met5]-enkephalin, [leu5]-enkephalin, cholec ... | 1991 | 1716907 |
| distribution and morphology of substance p-immunoreactive structures in the olfactory bulb and olfactory peduncle of the common marmoset (callithrix jacchus), a primate species. | the present study describes the morphology and distribution of substance p-immunoreactive (sp-ir) elements in the olfactory bulb (ob) and olfactory peduncle (op) of the common marmoset (callithrix jacchus), a primate species. sp-ir neurons are very abundant in the ob and belong to two types. external tufted cells are present in the glomerular layer (gl), whereas granule cells are found in the deeper layers, especially in the granule cell layer (grl), but also scattered in the op. sp-ir fibers, p ... | 1991 | 1724304 |
| mr 40,000 human colonic epithelial protein expression in colonic mucosa and presence of circulating anti-mr 40,000 antibodies in cotton top tamarins with spontaneous colitis. | saguinus oedipus, callithrix jacchus, and saguinus fuscicollis are three species of new world monkeys which develop a form of colitis that is similar to human ulcerative colitis. only s oedipus, however, develop colon cancer. we examined intestinal tissues from these animals for the presence of an antigen cross reacting to the mr 40,000 human colonic epithelial protein that acts as an autoantigen in ulcerative colitis. using an anti-mr 40,000 monoclonal antibody (7e12h12, igm isotype), by an imm ... | 1992 | 1740277 |
| an evaluation of two animal models for dietary influences on reproductive toxicology. | chronic protein deficiency (8 weeks) was examined in marmosets (callithrix jacchus) and sub-acute (1 week) methionine- and choline-deprivation was investigated in f344 rats. the marmosets were considered to have become protein-deficient but there was no alteration in sperm morphology, either at the end of the diet or 5 weeks later. weight loss was also observed in rats on the methionine- and choline-free diet and they had significantly decreased sperm counts 4 weeks after the end of treatment. h ... | 1991 | 1768785 |
| de novo biosynthesis and localization of inhibin in marmoset (callithrix jacchus) and rat epididymis. | using specific polyclonal antibodies generated against a 13 kd human testicular inhibin, immunocytochemical localization was carried out in epididymis of intact and castrated marmoset monkey and rat epididymis. inhibin was found to be present in the cytoplasm of epithelial cells of caput, corpus and cauda epididymis. the intensity of staining and pattern of distribution did not change following castration. further, the in vitro biosynthesis of inhibin studied by incorporating 3h-leucine and prec ... | 1991 | 1769713 |
| [wound healing of the cornea of new world monkeys after surface keratectomy: er:yag-excimer laser]. | corneal wound healing was studied after photoablation with an excimer laser (193 nm, 43 pulses at 180 mj/cm2 [symbol: see text] 11 microns ablation depth, optical zone 2.0 mm) and with an erbium-yag laser (2.94 microns, 5 pulses at 2.5 j/cm2 [symbol: see text] 50 microns ablation depth, optical zone 1.6 mm). the corneas of marmosets (callithrix jacchus) were prepared 5 and 10 days and 4 and 25 weeks after photoablation. the sections were investigated by conventional light microscopy or exposed t ... | 1991 | 1786926 |
| ontogeny of monooxygenase activities in the marmoset monkey (callithrix jacchus). | the pre- and postnatal development of monooxygenases in the liver and adrenal gland of marmoset monkeys (callithrix jacchus) was investigated. cytochrome p450 was detected in the fetal adrenal gland, but aldrin epoxidase, ethoxycoumarin o-deethylase, and ethoxyresorufin o-deethylase activities were below detection limits. although fetal hepatic cytochrome p450 was not detected, low activities of aldrin epoxidase and ethoxycoumarin o-deethylase, but no ethoxyresorufin o-deethylase, could be detec ... | 1991 | 1787526 |
| urinary protein pattern reflects social rank in male common marmosets (callithrix jacchus). | 1991 | 1794772 | |
| extensive loss of brain dopamine and serotonin induced by chronic administration of mptp in the marmoset. | common marmosets were given a subcutaneous injection of mptp (1.25-2.5 mg/kg twice a week) for 5 or 10 consecutive months and were sacrificed after a survival time of 6 months or 15 days, respectively. the parkinsonian symptoms were not very marked at the time of sacrifice but there was a strong decrease of dopamine and, to a lesser extent, of its metabolites in the striatum and in some extrastriatal regions. there was also a profound loss of serotonin in the striatum and in all of the extrastri ... | 1991 | 1815820 |
| lipoprotein(a) and apolipoprotein(a) in a new world monkey, the common marmoset (callithrix jacchus). association of variable plasma lipoprotein(a) levels with a single apolipoprotein(a) isoform. | in an earlier report (chapman et al, biochemistry 1979;18:5096-5108), we suggested that the common marmoset may represent an important model for the study of human plasma lipoprotein metabolism. we now extend the interest of this monkey model to the study of lipoprotein(a) (lp[a]) and apolipoprotein(a) (apo[a]). density gradient ultracentrifugal fractionation of marmoset plasma revealed a bimodal distribution of lp(a), with one peak of concentration occurring in association with very low density ... | 1991 | 1829630 |
| synergism of the ampa-antagonist nbqx and the nmda-antagonist cpp with l-dopa in models of parkinson's disease. | degeneration of dopaminergic nigrostriatal neurons in parkinson's disease results in an overactivity of excitatory glutamatergic projections from the subthalamic nucleus to the output nuclei of the basal ganglia resulting in rigidity and akinesia. in theory pharmacological blockade of these overactive systems should improve parkinsonian symptomatology. the selective ampa-antagonist nbqx and the competitive nmda-antagonist cpp are not effective in animal models of parkinson's disease when given a ... | 1991 | 1835581 |
| morphological and histochemical effects of 2,3,7,8-tetrachlorodibenzo-p dioxin (tcdd) on marmoset (callithrix jacchus) testes. | the testes of marmosets (callithrix jacchus), which had been treated with a single dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) (0.3 microgram to 10 micrograms/l kg body weight (bw)) were studied after 7 days using morphological and histochemical techniques. light microscopic and electron microscopic examination revealed decreased intercellular contact in the germinal epithelium, as indicated first by enlarged intercellular spaces between the sertoli's cells and between the sertoli's cells ... | 1991 | 1872647 |
| differential effects of dietary fish oil on myocardial prostaglandin i2 and thromboxane a2 production. | marmoset monkeys (callithrix jacchus) were maintained for 24 mo on a standard primate diet [reference (ref) diet] or this diet supplemented (8% wt/wt) with either sheep fat (sf), sunflower seed oil (sso), or tuna fish oil (tfo). the polyunsaturated fatty acids (pufa) of myocardial phospholipids demonstrated significant alterations as a result of the dietary (n-3) or (n-6) lipid supplementation. the reduction (p less than 0.05) in prostaglandin (pg) i2 in pufa diet-fed groups (sso, 113.8 +/- 7.8; ... | 1991 | 1899979 |
| ultrastructural and histochemical characterization of marmoset (callithrix jacchus) leydig cells during postnatal development. | leydig cell development was investigated in the marmoset (callithrix jacchus) testis from 24 h post partum (pp) up to sexual maturity, using ultrastructural and histochemical methods. electron microscopically three different leydig cell (lc) types could be distinguished: neonatal, immature and adult lcs. neonatal lcs exhibited a round nucleus, large tubular mitochondria, abundant smooth endoplasmic reticulum (ser), and few small fat vesicles. the typical immature lcs showed a lobulated nucleus, ... | 1991 | 1903613 |
| olfactory bulb granule cell aggregates: morphological evidence for interperikaryal electrotonic coupling via gap junctions. | anaxonic interneurons of the granule cell type in the mammalian main olfactory bulb (mob) are characterized by prominent membrane specializations, which include reciprocal, interdendritic chemical and electrical synapses; however, the latter are thought to be restricted to the external plexiform layer (epl) and connect granule-mitral- and granule-tufted-cell dendrites (landis et al., 1974). the present study focuses on interperikaryal membrane specializations between tangentially oriented aggreg ... | 1991 | 1904478 |
| polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 2. in vitro effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on lymphocytes of venous blood from man and a non-human primate (callithrix jacchus). | the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on poke weed mitogen-stimulated proliferation and differentiation of peripheral lymphocytes was studied in vitro with cells from a non-human primate (marmoset monkey, callithrix jacchus) and from man. monoclonal antibodies and flow cytometry (facscan) were used for analysis. the extent of the overall mitogen-stimulated proliferation of isolated lymphocytes in vitro from marmoset blood was only slightly reduced in the presence of tcdd compa ... | 1991 | 1905127 |
| treatment with antioxidants does not prevent loss of dopamine in the striatum of mptp-treated common marmosets: preliminary observations. | administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) to common marmosets causes a profound loss of dopamine and serotonin in the striatum. additional daily systemic treatment of monkeys with the antioxidants ascorbic acid (100 mg/kg) and alpha-tocopherol (2,350 mg/kg) prior to, during and following administration of mptp does not prevent the loss of dopamine and serotonin in the striatum, suggesting that these antioxidants are unable to protect dopaminergic neurones against neur ... | 1991 | 1905937 |
| immunohistochemical distribution of the collagen types iv, v, vi and glycoprotein laminin in the healthy rat, marmoset (callithrix jacchus) and human gingivae. | the purpose of this study was to demonstrate the localization of collagen types iv, v and vi as well as the glycoprotein laminin in biopsies of healthy rat, marmoset (callithrix jacchus) and human gingivae. the slices, after the use of indirect immunofluorescence (incubation with antibodies against these extracellular matrix components), showed the same distribution with the anti-type iv and laminin antibodies on the basement membranes of the epithelium, blood vessels and nerves. collagen type v ... | 1991 | 1906570 |
| co2 breath tests using 14c-caffeine, 14c-methacetin and 14c-phenacetin for assessing postnatal development of monooxygenase activities in rats and marmosets. | the time course in which the activities of cytochrome p450-dependent drug-metabolizing enzymes develop during the perinatal period differs for various types of monooxygenases as well as for various animal species. using [3-methyl14c]-, [7-methyl14c]-caffeine, [14ch3]-methacetin and [14c2h5]-phenacetin as substrates in breath tests, the developmental changes in the rates of 14co2 formation, due to changes in the activity of monooxygenases, were studied in rats and marmoset monkeys (callithrix jac ... | 1991 | 1914790 |
| collection and analysis of semen from the common marmoset (callithrix jacchus). | the authors examined the seminal characteristics of 16 male common marmosets (callithrix jacchus) to provide baseline data for future studies of the reproductive biology of this species. semen samples were collected by electroejaculation. there was considerable inter- and intra-male variation in all seminal characteristics. the median seminal volume was 30 microliters (range 8 to 85 microliters), and the median total sperm count was 5.1 x 10(6) sperm (range, 0.1 to 43 x 10(6]. the median progres ... | 2003 | 1917685 |
| [the significance of pcdd's/pcdf's (dioxins) in pediatrics]. | no epidemiological data are available up to now which reveal adverse effects induced by dioxins during an exposure through breast milk. furthermore, very few data on the concentration of pcdds/pcdfs in the newborn and during the first year of life have been published. of all pcdds/pcdfs, the substance with the highest toxicity is 2,3,7,8-tetrachlorodibenzo-p-dioxin. however, in the environment this congener is often only a minor component. a sensitive biological effect triggered by tcdd is the e ... | 1991 | 1961212 |
| [3h]harman binding experiments. ii: regional and subcellular distribution of specific [3h]harman binding and monoamine oxidase subtypes a and b activity in marmoset and rat. | [3h]harman (1-[3h]methyl-beta-carboline) was used in a novel radioligand binding assay to label selectively and with high affinity monoamine oxidase (mao) type a. the concentration of the enzyme was determined in six cns regions of the primate species marmoset (callithrix jacchus) and of the rat: hypothalamus, hippocampus, cerebellum, cerebral cortex, striatum, and spinal cord. the specific [3h]harman binding in the cns of the marmoset reveals the same pharmacological profile and other character ... | 1991 | 1988553 |
| [yersinia pseudotuberculosis in new world monkeys]. | it is reported on four cases of pseudotuberculosis in 2 saimiri sciureus, 1 callithrix jacchus/penicillata hybrid and 1 s. oedipus. the animals came from two different groups, one being infected with y. pseudotuberculosis serotype i, the other with y. pseudotuberculosis serotype ii. all cases showed intestinal infection of thermophile campylobacter. remarkable were severe haemorrhagic components and the distinct rhs-proliferation, especially in the mesenteric lymphatic nodes. | 1991 | 2015031 |
| penile spines affect copulatory behaviour in a primate (callithrix jacchus). | androgen-dependent, keratinized "spines" occur on the glans penis in many rodents, primates and other mammals. since penile spines overlie dermal tactile receptors, they may play a role in copulatory behaviour. an experiment was conducted to test this hypothesis. sixteen sexually experienced adult male marmosets were paired with ovariectomized females before, and after, removal of penile spines (using thioglycollate cream applied to the glans under anaesthesia) or a sham operation. spine removal ... | 1991 | 2062934 |
| cell proliferation in the subependymal layer of the postnatal marmoset, callithrix jacchus. | cells of the subependymal layer (sel) have been shown to be capable of continued postnatal cell division throughout life in rodents. to determine if the primate brain behaves similarly, proliferative activity in the sel of the marmoset has been investigated by tritiated thymidine autoradiography and bromodeoxyuridine immunocytochemistry. both methods revealed the presence of dna-synthesizing cells at all postnatal ages studied. the labelling index (li), low at birth, reached a peak of almost 4% ... | 1990 | 2073725 |
| synthesis of human renin inhibitory peptides, angiotensinogen transition-state analogs containing a retro-inverso amide bond. | the experimental details for the synthesis of human renin inhibitors are described. in order to avoid metabolic degradation of the phe-his (p3-p2) amide bond in transition-state analogs, structurally modified acyl residues (p4-p3) were incorporated into the inhibitors. compound 1a, which contained 2-(1-naphthylmethyl)-3-(n-phenethylcarbamoyl)propionyl residue (p4-p3) with a retro-inverso amide bond, l-histidine, and norstatine isoamylamide residue (p1-p1) as a transition-state mimic, had potent ... | 1990 | 2085885 |
| evaluation of the toxicity of indomethacin in a 4-week study, by oral route, in the marmoset (callithrix jacchus). | a subacute toxicity study of indomethacin administered by oral route, was carried out in the marmoset (callithrix jacchus). groups of three males and three females received indomethacin directly into the stomach by means of a catheter for a period of 4 weeks at the dose levels of 0, 2, 6, and 12 mg/kg body wt/day and then were euthanized for pathological evaluation. all marmosets given 12 mg/kg/day and one marmoset given 6 mg/kg/day died during the dosing period (within 20 days). at 12 mg/kg/day ... | 1990 | 2086319 |
| lack of change in striatal darpp-32 levels following nigrostriatal dopaminergic lesions in animals and in parkinsonian syndromes in man. | the present study was performed to determine the effect of a nearly complete nigrostriatal dopaminergic denervation on darpp-32 levels in the striatum from animals and parkinsonian patients. darpp-32 levels were estimated by in vitro phosphorylation in the presence of camp, or after inactivation of endogenous kinases and phosphatases, in the presence of the catalytic subunit of camp-dependent protein kinase. intranigral 6-hydroxydopamine (6-ohda) infusion in rats, or peripheral administration of ... | 1990 | 2105823 |
| medial hypothalamic lesions and sexual receptivity in the female common marmoset (callithrix jacchus). | medial hypothalamic lesions cause major deficits in sexual receptivity in a variety of mammalian species. effects of such lesions upon sexual receptivity in female primates have not been investigated. two experiments are described in which thermal lesions were made in the hypothalamus in 11 ovariectomized or ovariectomized/adrenalectomized, oestradiol-treated common marmosets. proceptivity (sexual initiating behaviour) was reduced or abolished by lesions in the dorsomedial or ventromedial hypoth ... | 1990 | 2108915 |
| genetically distinct cell populations in naturally occurring bone marrow-chimeric primates express similar mhc class i gene products. | the cotton-top tamarin (saguinus oedipus) is a naturally occurring "a" + "b"----"a" bone marrow-chimeric species. these primates usually are born as dizygotic twins and, due to placental vascular anastomoses, develop sharing each others' bone marrow elements. strikingly, almost 50% of the pbl of a member of a twin pair are derived from the hematopoietic stem cells of its cotwin. to clarify the mechanisms underlying the maintenance of tolerance in these stable chimeras, mhc gene products have bee ... | 1990 | 2110210 |
| immunoregulation in the common marmoset, calithrix jaccus: functional properties of t and b lymphocytes and their response to human interleukins 2 and 4. | non-human primates have been used to study immune function to a much lesser extent than readily available strains of inbred rodents. nevertheless, in situations where it might be desirable, but impossible, to study human immune responses in vivo, lower primates could provide an acceptable alternative. in order to extent the knowledge of t- and b-lymphocyte function in lower primates, the common marmoset callithrix jaccus was used as an experimental model. the functional similarities between this ... | 1990 | 2110549 |
| plasma vitamins a and e and hydrogen peroxide-induced in vitro erythrocyte haemolysis in common marmosets (callithrix jacchus). | plasma total lipid, cholesterol, all-trans retinol (vitamin a) and alpha-tocopherol (vitamin e) concentrations, and the susceptibility of erythrocytes to hydrogen peroxide-induced haemolysis in vitro were investigated in healthy laboratory-bred common marmosets (callithrix jacchus). the concentrations of alpha-tocopherol and total cholesterol were similar to those of control human subjects. the mean lipid concentration was higher (p less than 0.025) and the retinol concentration lower (p less th ... | 1990 | 2111954 |
| isolation and characterization of several plasma apolipoproteins of common marmoset monkey. | to explore the potential of the common marmoset monkey (callithrix jacchus) as a model for human plasma lipoprotein metabolism, several marmoset apolipoproteins were isolated and characterized in this study. based on several properties, including molecular weight, amino acid composition, and sequence, the marmoset apolipoproteins are strikingly similar to human apolipoprotein (apo) a-i, a-ii, c-iii, and a-iv. the first 54 residues of marmoset apo a-i showed 87% sequence identity with the corresp ... | 1990 | 2114867 |
| isolation and characterization of plasma lipoproteins of common marmoset monkey. comparison of effects of control and atherogenic diets. | this study examines the potential of the common marmoset monkey (callithrix jacchus) to serve as a model for human lipoprotein metabolism and atherosclerosis. the lipoproteins of animals fed a low-fat, low-cholesterol diet and a high-fat (12% wt/wt lard), high-cholesterol (0.34% wt/wt) diet were characterized by the combination of sequential ultracentrifugation and pevikon block electrophoresis. based on chemical and physical properties, equivalents of human very low density lipoproteins (vldl), ... | 1990 | 2114868 |
| distribution of two morphologically distinct subsets of serotoninergic axons in the cerebral cortex of the marmoset. | the serotoninergic innervation of the marmoset (new world monkey, callithrix jacchus) cerebral cortex has been analyzed by using immunocytochemistry. the use of a sensitive monoclonal antibody against serotonin allowed the visualization of the fine morphology of individual axons. two types of terminal axons were demonstrated: one has sparse, small, ovoid varicosities (dia. less than 1 micron), and the other has large, spheroidal varicosities (up to 5 microns in dia.), which are more densely clus ... | 1990 | 2115053 |
| ofloxacin in juvenile non-human primates and rats. arthropathia and drug plasma concentrations. | arthropathia in juvenile animals is the most important toxic effect induced by quinolones. we conducted pharmacokinetic and morphological studies with ofloxacin on non-human primates (callithrix jacchus, marmosets) and rats. in the marmoset, electron microscopy and the application of immuno-morphological methods proved to be suitable for the detection of specific alterations in cartilage (e.g. loss of proteoglycans and altered chondrocytes). subsequently performed electron microscopic examinatio ... | 1990 | 2115323 |
| plasma melatonin exhibits a diurnal secretion in the common marmoset (callithrix jacchus): relationship to the rest-activity cycle. | the secretion of plasma melatonin exhibits a diurnal variation in the common marmoset (callithrix jacchus jacchus) (n = 12) with mean values of 125.8 fmol/ml during darkness and below assay sensitivity (mean 70.5 fmol/ml) during the light period. both melatonin secretion and the rest activity cycle appeared to be phase advanced with relation to the light dark cycle which is consistent with an endogenous circadian period (tau) of less than 24 h in this species. | 1990 | 2116518 |
| suppression of bioactive luteinizing hormone and testosterone by a progesterone antagonist zk 98.734 in adult male common marmosets, callithrix jacchus. | the effects of a progesterone antagonist zk 98.734 on release of bioactive luteinizing hormone (lh) and testosterone were studied in adult male common marmosets by using the following experimental protocols: (1) the blocking of the nocturnal rise in testosterone levels by zk 98.734, (2) the pharmacodynamic effects of zk 98.734 on testosterone and lh levels, (3) the reversal of zk 98.734-induced decrease in testosterone by treatment with human chorionic gonadotropin (hcg), and (4) the blocking of ... | 1990 | 2116922 |
| 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-mptp) is less neurotoxic than mptp in the common marmoset. | four adult marmosets were treated with increasing doses of 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'-methyl-mptp) in the range 0.23-4.3 mg/kg i.p. to give a cumulative dose of 11.0-11.6 mg/kg over a 6-10 day period. after 4 days of treatment, and as the dosage was gradually increased, the animals exhibited mild motor deficits. these abnormalities slowly declined over the following 1-6 week period. in contrast, similar treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6 ... | 1990 | 2117541 |
| immunofluorescence-microscopic localization of collagen type iv and vi, laminin and nidogen in the livers of callithrix jacchus during pre- and postnatal development. | the distribution of collagen type iv and vi, laminin and nidogen was investigated by immunofluorescence microscopy in the livers of marmosets (callithrix jacchus) at various stages of development, i.e. on days 93, 111, 116 and 134 of gestation, 1 day postpartum and at the mature stage. large amounts of collagen type iv could in all cases be demonstrated in the sinus wall and in all basal laminae outside the lobule. after the application of antibodies against collagen type vi the sinus wall showe ... | 1990 | 2117839 |
| n-3 and n-6 phosphoglyceride fatty acids in relation to in vitro erythrocyte haemolysis induced by hydrogen peroxide in captive common marmosets (callithrix jacchus). | 1. hydrogen peroxide-induced haemolysis (hpih) was studied in the red blood cells of the common marmoset monkey (callithrix jacchus) in relation to the composition of the membrane fatty acids. hpih (%) was surprisingly high (mean 41% +/- 34; median 33.4%) and significantly different (p less than 0.001) from the corresponding value in healthy human subjects (mean 0.98% +/- 0.6; median 1.3%). 2. it was negatively correlated with 18:2n-6 (r = -0.76, p less than 0.001), 18:2n-6/20:4n-6 (r = -0.70, p ... | 1990 | 2123763 |
| persistence of various polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) in hepatic and adipose tissue of marmoset monkeys. | a defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) was subcutaneously administered to marmoset monkeys (callithrix jacchus). tissue concentrations in hepatic and adipose tissue were measured at different times after treatment (1-28 weeks). one week after application high concentrations could be detected for the 2,3,7,8-substituted congeners only. the percent of the administered dose in whole liver differed for the various 2,3,7,8-substituted congeners, ran ... | 1990 | 2125825 |
| transfer of various polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) via placenta and through milk in a marmoset monkey. | a defined mixture of polychlorinated dibenzo-p-dioxins and dibenzofurans (pcdds and pcdfs) was subcutaneously administered to a pregnant marmoset monkey (callithrix jacchus) 11 weeks prior to delivery. transfer of pcdds and pcdfs via placenta and mother's milk was investigated by measurement of concentrations in a newborn 1 day after birth and in an infant of the same litter after a lactation period of 33 days. furthermore, comparative measurements were performed in different tissues of the moth ... | 1990 | 2128593 |
| monoclonal antibodies from epstein-barr virus-transformed lymphocytes of common marmosets (callithrix jacchus) immune to malaria. | the b lymphocytes of the common marmoset callithrix jacchus can be immortalized by infection with epstein-barr virus (ebv) in vitro (desgranges et al., 1976). c. jacchus is susceptible to infection with the blood stages of several species of malaria parasite including the line designated mvf1 (mitchell et al., 1988) from which it recovers and shows immunity to reinfection. by exploiting these two phenomena, ebv-transformed, marmoset lymphoblastoid cell lines secreting antibodies to malaria paras ... | 1990 | 2155967 |
| adenocarcinoma of the small intestine in a common marmoset (callithrix jacchus). | 1990 | 2157108 | |
| inhibin secretion during the ovulatory cycle and pregnancy in the common marmoset monkey. | changes in plasma concentrations of immunoreactive inhibin in the reproductively cyclic, pregnant and ovariectomized female marmoset monkey (callithrix jacchus) were measured with a heterologous radioimmunoassay. the pattern of inhibin secretion in five marmosets studied individually during four consecutive cycles was shown to resemble that of progesterone. in these animals, data were pooled according to stage of cycle on the basis of plasma progesterone concentrations. mean values for inhibin w ... | 1990 | 2212937 |
| screening procedure for assessment of ototoxicity in the common marmoset. | detection of drug-induced ototoxicity in safety evaluation studies of novel chemical entities is rarely attempted. where such examinations are included, they usually rely on reflex testing. the brainstem auditory evoked response can be measured with the use of externally positioned electrodes, and it monitors electrophysiologic responses to sound from the cochlear nerve and associated structures of the 8th cranial nerve. these responses have been reproducibly measured in sedated marmosets and th ... | 1990 | 2214803 |
| the facial artery of the common marmoset (callithrix jacchus). | the facial artery and its ramifications in 7 adult common marmosets (callithrix jacchus) were studied by the plastic injection method. the findings obtained are discussed in comparison with those for other primates. in the submandibular region, the facial artery arose from the external carotid artery at the height of the atlas via the linguofacial trunk on 10 of the total of 14 sides examined and independently on the other 4 sides. this common trunk always gave rise to the superior thyroid arter ... | 1990 | 2216318 |
| [the distribution of different collagen types and laminin in the gingiva of the common marmoset (callithrix jacchus)]. | the distribution of the collagen types i, iii, iv, v, vi and of the glycoprotein laminin have been examined in the healthy gingiva of the marmoset with the indirect immunofluorescence method. it has been shown that collagen type i formed thick fibrils in a wave-like pattern, while collagen type iii formed thinner fibrils, especially under the epithelial basal membrane. collagen type iv and laminin showed a strong fluorescence in the basal membrane (epithelium, vessels, nerves). collagen type v h ... | 1990 | 2237364 |
| extension of reproductive suppression by pheromonal cues in subordinate female marmoset monkeys, callithrix jacchus. | pheromonal signals from the dominant female marmoset monkey were implicated in maintaining the suppression of lh secretion and ovulation in socially subordinate females. when subordinate, and reproductively suppressed, female marmoset monkeys were removed from their group without scent contact with their dominant females, subordinate females in control group 1 (n = 8) and control group 2 (n = 5), ovulated 10.8 +/- 1.4 days and 10.4 +/- 0.8 days respectively (mean +/- s.e.m.) after separation. su ... | 1990 | 2250240 |
| studies on the ascorbic acid metabolism of callitrichid monkeys by 14c isotope excretion technique. | recently it has been found that the two monkey species callithrix jacchus and saguinus fuscicollis, both belonging to the same new world monkey family callitrichidae and held in the same colony under identical conditions, had extremely different serum ascorbate levels. to examine the ascorbic acid metabolism the 14c-excretion of orally given 1-14c-ascorbic acid was studied under conditions of marginal and abundant vitamin c supply and under intentional stress. there were large differences in the ... | 1990 | 2251861 |
| [radiotelemetric studies of the body temperature of white-tufted monkeys (callithrix jacchus)]. | a newly developed telemetry system was used to study deep body temperature (bt) of two adult male common marmosets (callithrix jacchus). the bt-curves of both monkeys showed a similar clear circadian rhythm with a range up to 3.5 degrees c. at environmental temperature of 28 degrees c (et) the bt of the monkeys varied in the daytime dependent on their spontaneous activity, with little individual differences between 37.5 degrees c and 39.3 degrees c; at night the bt of the remarkably deeply-sleep ... | 1990 | 2251862 |
| transmammary transmission of mesocercariae of alaria marcianae (trematoda) in experimentally infected primates. | a lactating primate, callithrix jacchus, was infected experimentally with 600 mesocercariae of alaria marcianae 10 days after parturition to determine if she would transmit the mesocercariae to her offspring. her twin infants were examined 4 wk postinoculation and 16 mesocercariae were found in their tissues. the female was mated again and gave birth to a litter of triplets. she was not given additional mesocercariae. one infant died within hours of birth without suckling and was found negative ... | 1990 | 2254822 |
| chromosomal evolution in callithrix emiliae. | we studied the karyotype of specimens of callithrix emiliae (callithricidae, primates) from rondonia, brazil. comparison with the karyotype of callithrix jacchus showed that, even though these two species show many karyotypic similarities, they differ by a robertsonian translocation, a paracentric inversion and large-scale addition of heterochromatin. the c. emiliae species appears to be in an active phase of chromosome evolution by the addition of constitutive heterochromatin. | 1992 | 2272240 |
| morphology of neuropeptide y-immunoreactive neurons in the cat olfactory bulb and olfactory peduncle: postnatal development and species comparison. | the distribution and morphology of neuropeptide y-immunoreactive (npy-ir) neurons in the olfactory bulb and the olfactory peduncle was studied in the adult cat and rat, and the common marmoset callithrix jacchus. significant species differences were not observed. in all three species, the population of npy-ir neurons is localized in the white matter extending from the main olfactory bulb to the border of the striatum. the neurons are characterized by a conspicuously looping axonal ramification p ... | 1990 | 2298945 |
| an ultrastructural study of early chorionic villus formation in the marmoset monkey (callithrix jacchus). | the ultrastructural morphology of developing chorionic villi in the marmoset monkey (callithrix jacchus) placenta was studied in pregnant monkeys at known time intervals after ovulation. in samples obtained at 45 days after ovulation the mesoderm, which consists of primitive foetal blood vessels, is seen to extend down into cytotrophoblast columns. syncytiotrophoblast completely surrounds maternal blood vessels and both basal laminae and endothelial cells of maternal origin show signs of disorga ... | 1990 | 2305971 |
| a lobster claw abnormality in the common marmoset (callithrix jacchus). | a congenital abnormality of the digits, similar to the 'lobster claw' deformity of humans, was observed in 8 common marmosets. the condition varied in severity and in effect on the animals; it appeared to be due to a single autosomal recessive trait. | 1990 | 2366513 |
| the topology of the thalamo-cortical projections in the marmoset monkey (callithrix jacchus). | this paper addresses the question of a general topological principle of thalamo-cortical projections. in the lissencephalic primate brain of the common marmoset (callithrix jacchus), large injections of horseradish peroxidase were made in various parts of the neocortex. these injections were placed in different animals and hemispheres along various caudo-rostral and medio-lateral gradients. labelled cells in the thalamus were plotted and the labelling-zones resulting from several injections alon ... | 1990 | 2394218 |
| polyhalogenated dibenzo-p-dioxins and dibenzofurans and the immune system. 1. effects on peripheral lymphocyte subpopulations of a non-human primate (callithrix jacchus) after treatment with 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd). | monoclonal antibodies were used to analyse the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (tcdd) on peripheral lymphocytes from marmosets (callithrix jacchus) following injections of single low doses of tcdd. a reduction of the percentage and the total number of lymphocytes among the white blood cells was seen 3 weeks after a single administration of 300 ng tcdd/kg body wt, but not following 167 ng tcdd/kg or less. after treatment of marmosets with the single subcutaneous dose of 10 ng tcdd/ ... | 1990 | 2403285 |
| lack of change in basal ganglia neuropeptide content following subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine treatment of the common marmoset. | treatment of common marmosets with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp; 1-4 mg/kg for up to 4 days) caused a profound parkinsonian state. ten days from the start of mptp treatment, all animals showed marked motor impairment, consisting of bradykinesia and akinesia, limb rigidity, postural abnormalities, loss of vocalisation and blink reflex, and, on occasions, postural tremor. measurement of caudate-putamen monoamine content at this time showed a profound loss in 3,4-dihydroxyphen ... | 1986 | 2428937 |
| dietary lipid modulation of myocardial beta-adrenergic mechanisms, ca2+-dependent automaticity, and arrhythmogenesis in the marmoset. | dietary lipid supplements high in either saturated fatty acids derived from sheep perirenal fat or polyunsaturated fatty acids (65% linoleic acid) derived from sunflower seed oil were fed to marmoset monkeys (callithrix jacchus) for 20 months. the effect of these long-term dietary lipid supplements on myocardial contractile function and their influence on responses to isoprenaline and external calcium concentration were examined using isolated papillary muscles and atria. isoprenaline potency wa ... | 1987 | 2444777 |
| distribution and some projections of cholinergic neurons in the brain of the common marmoset, callithrix jacchus. | the distribution of choline acetyltransferase-immunoreactive (chat-ir) neurons was studied in the brain of the common marmoset by using immunohistochemistry. chat-ir neurons were found in the medial septal nucleus, vertical and horizontal limb nuclei of the diagonal band, the nucleus basalis of meynert, pedunculopontine nucleus and laterodorsal tegmental nucleus, and also in the striatum, habenula, and brainstem cranial nerve motor nuclei. the organization of chat-ir neurons in the basal forebra ... | 1988 | 2454972 |
| persistence of the pars externa system of the anterior olfactory nucleus in a microsmatic primate, callithrix jacchus. | the pars externa (pe) system of the anterior olfactory nucleus (aon) in a primate, callithrix jacchus, was defined by its architecture and by its connection patterns with the main olfactory bulb (mob) as revealed by tracing techniques. focal, unilateral injections of wheat germ agglutinin-conjugated horseradish peroxidase into the mob yielded ipsilaterally labelled afferent neurons in all subdivisions of the aon, with the exception of a clearly circumscribed area in the ventrolateral retrobulbar ... | 1988 | 2458800 |
| levels of met-enkephalin, leu-enkephalin, substance p and cholecystokinin in the brain of the common marmoset following long term 1-methyl-4-phenyl-1,2,3,6,-tetrahydropyridine treatment. | common marmosets were treated daily with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp, 7-9 mg/kg i.p.) for 25 days, and then kept out of drug for three months before biochemical measurements in various brain areas. this treatment induced a dramatic fall (-80%) in dopamine, homovanillic acid and dihydroxyphenylacetic acid levels in the putamen and caudate nucleus, and a significant but less pronounced reduction (less than or equal to 50%) in the levels of these compounds in the nucleus accu ... | 1988 | 2468106 |
| loss of ocular dominance columns with maturity in the monkey, callithrix jacchus. | previous studies have shown that adult marmosets lack ocular dominance columns (odc) in area 17, but that odcs can be demonstrated upon visual deprivation. the present results, obtained by transneuronal transport of wga-hrp, indicate that odcs normally develop in juvenile marmosets but disappear before the animal reaches maturity. the findings suggest that formation of odcs during ontogenesis, and their persistence through adulthood, are different developmental processes depending on different m ... | 1989 | 2472851 |
| differences in transneuronal transport of horseradish peroxidase conjugated wheat germ agglutinin in the visual system: marmoset monkey and guinea pig compared. | conjugates of the lectin wheat germ agglutinin with horseradish peroxidase have been described as effective transneuronal tracers in different neuronal systems of various mammalian species. here, the failure is described to detect any sign of transneuronal transport of the tracer in the visual system of adult marmoset monkeys (callithrix jacchus), in spite of heavy anterograde labeling in the primary visual centers after intravitreous injections. in contrast, in the brains of guinea pigs process ... | 1989 | 2473107 |
| connective tissue of the livers of newborn and adult marmosets (callithrix jacchus). | immunofluorescence microscopic and electron microscopic investigations revealed components of the matrix and of the basal lamina (collagen type i, iii, iv and v, bl-heparan sulfate and fibronectin) in the sinus wall (disse's space) of the livers of newborn and adult marmosets (callithrix jacchus). collagen type i was missing in both the two age groups. small amounts of laminin were present in the livers of newborn and absent in those of adult animals, whereas collagen type iii occurred in the fo ... | 1989 | 2485198 |
| comparison of the metabolism and disposition of [3-14c]coumarin in the rat and marmoset (callithrix jacchus). | male sprague-dawley rats and marmosets were given a single oral 25 mg/kg dose of [3-14c]coumarin and the excretion of radioactivity in the expired air, urine and faeces monitored up to 96 h. excretion profiles were similar in both species with the bulk of the dose being excreted in the urine and faeces within 24 h. chromatographic analysis of 0-48 h urine samples revealed similar metabolic profiles with only small amounts of unchanged coumarin and very little 7-hydroxycoumarin. coumarin 7-hydrox ... | 1989 | 2493171 |
| developmental changes in luteinizing hormone/human chorionic gonadotropin steroidogenic responsiveness in marmoset granulosa cells: effects of follicle-stimulating hormone and androgens. | factors regulating lh/hcg responsiveness in primate granulosa cells were examined in the marmoset monkey (callithrix jacchus). granulosa cells were isolated and pooled from small antral (0.5-1.0 mm) and large preovulatory (greater than or equal to 2 mm) follicles from mid- to late follicular phase ovaries of cyclic marmosets. the cells from small and large follicles were cultured in serum-free medium for 48 h in the absence or presence of increasing concentrations of hcg (0.1-100 ng/ml) with or ... | 1989 | 2494036 |
| the diagnostic usefulness of isocitrate dehydrogenase (icdh) in the marmoset (callithrix jacchus). | marmosets were given either a hepatotoxin, carbon tetrachloride, orally or an i.m. injection of a mytoxin, chlorpromazine. although muscle damage alone caused small increases in the plasma levels of lactate dehydrogenase, alanine aminotransferase, aspartate aminotransferase and isocitrate dehydrogenase (icdh), only the isoenzyme analysis of icdh can differentiate definitely between liver and muscle damage. only very severe muscle damage can increase the plasma concentration of this enzyme but, i ... | 1989 | 2494250 |
| the evolution and distribution of morphological changes in the nervous system of the common marmoset following the acute administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. | six young adult marmosets received 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in multiple doses (total 8-16 mg/kg over 2-13 days) sufficient to produce a parkinsonian syndrome and were killed up to 3.5 months later. cellular changes were found in the substantia nigra, ventral tegmental area, and hypothalamus. the earliest histological abnormalities were axonal swellings in proximal parts of nigrostriatal axons. subsequent changes in the substantia nigra were reduced nissl staining, reduced cel ... | 1989 | 2494438 |
| the distribution of glial fibrillary acidic protein and vimentin in postnatal marmoset (callithrix jacchus) brain. | antisera to glial fibrillary acidic protein (gfap) and vimentin were used to elucidate the distribution of these intermediate filament proteins in postnatal marmoset brains of various ages. the ependyma of the lateral ventricles was unique in being equally immunoreactive for both gfap and vimentin at all ages. vimentin alone was consistently demonstrated in endothelial and leptomeningeal cells at all ages. in neonates, vimentin immunoreactivity greatly exceeded that of gfap and was located prima ... | 2008 | 2496940 |
| ascorbic acid in a new world monkey family: species difference and influence of stressors on ascorbic acid metabolism. | like other simian primates, the new world monkey callithrix jacchus, marmoset, and saguinus fuscicollis, tamarin, require ascorbic acid as an essential nutrient. for adult marmosets, a daily intake of 15 mg/kg metabolic body weight was found to be necessary to obtain a serum level above the kidney threshold. a survey of the serum ascorbic acid level of marmosets and tamarins in a breeding colony resulted in a vast divergence between the two species, indicating a higher ascorbic acid requirement ... | 1989 | 2497592 |
| heinz bodies do not modify the membrane characteristics of common marmoset (callithrix jacchus) erythrocytes. | the possibility was examined that the membrane function of erythrocytes obtained from healthy common marmosets (callithrix jacchus) was modified by the presence in the cells of heinz bodies. no significant differences were found in erythrocyte endogenous free malonyl dialdehyde (mda) or reduced glutathione (gsh) between normal human erythrocytes and marmoset erythrocytes containing heinz bodies. membrane fluorescent chromolipids, surface charge and thiol levels were similar in both species but a ... | 1989 | 2498578 |
| comparative studies on nafenopin-induced hepatic peroxisome proliferation in the rat, syrian hamster, guinea pig, and marmoset. | nafenopin was administered orally for 21 days to male sprague-dawley rats (0.5-50 mg/kg/day), syrian hamsters (5-250 mg/kg/day), dunkin-hartley guinea pigs (50 and 250 mg/kg/day), and marmosets (callithrix jacchus, 50 and 250 mg/kg/day). with the rat, and to a lesser extent in the hamster, nafenopin treatment produced dose-related increases in liver size and induction of peroxisomal (palmitoyl-coa oxidation) and microsomal (lauric acid 12-hydroxylase) fatty acid oxidizing enzyme activities. in c ... | 1989 | 2499080 |
| experimental brugia pahangi and b. malayi infections of callitrichid primates. | the callitrichid primates, callithrix jacchus jacchus (the marmoset) and saguinus labiatus (the tamarin) were inoculated with infective larvae of brugia malayi and b. pahangi. microfilaraemia at low levels developed in 3 out of 4 c.j. jacchus infected with b. malayi and living or dead adult worms found in all 4. only one of 4 c.j. jacchus became microfilaraemic (mf + ve) when given b. pahangi and adults were found in two. of 4 s. labiatus given b. pahangi one became very lightly mf + ve and adul ... | 1989 | 2500478 |