Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| synthesis and antiprotozoal activity of 2,5-bis(4-guanylphenyl)thiophenes and -pyrroles. | 1977 | 336890 | |
| chloroquine susceptibility in malaria: dependence on exposure of parasites to the drug. | 1977 | 337017 | |
| isolation and analysis of nucleotides from erythrocyte-free malarial parasites (plasmodium berghei) and potential relevance to malaria chemotherapy. | studies using erythrocyte-free preparations of p. berghei were conducted with a view to improving knowledge of parasite metabolism, particularly nucleotide metabolism. the free parasites employed in these studies were prepared by saponin lysis of parasitized mouse erythrocytes in isotonic glucose solutions. a comparative study of post-lytic metabolic activity of free parasites prepared by saponin, ammonium chloride, or osmotic lysis indicated a significantly greater retention of metabolic activi ... | 1977 | 338182 |
| the chemotherapy of rodent malaria, xxvii. studies on mefloquine (wr 142,490). | mefloquine (wr 142,490) is a potent blood schizontocide active against drug-sensitive and drug-resistant lines of plasmodium berghei. the ed50 and ed90 against the p. berghei n strain in albino mice are 1.5 and 3.8 mg/kg respectively. the highly chloroquine-resistant rc line is less sensitive and mefloquine is not fully effective at the maximum tolerated dose in the '4-day test'. mefloquine has a similar mode of action to quinine both in vitro and (as demonstrated by the morphological changes it ... | 1977 | 339856 |
| the chemotherapy of rodent malaria, xxviii. the development of resistance to mefloquine (wr 142,490). | 1977 | 339857 | |
| studies on parasitic crisis in malaria: i. signs of impending crisis in plasmodium berghei infections of the white rat. | white rats infected with plasmodiam berghei were observed throughout the course of infection for indicators of impending crisis (penultimate stage). two ratios, percentage young compact forms:percentage trophozoites and percentage reticulocytes:percentage parasitaemia, were reliable markers of the penultimate period and impending crisis. when the percentage young compact form:percentage trophozoite ratio exceeded 1.0 and was coincident with an increase of uninfected reticulocytes in the circulat ... | 1977 | 339858 |
| the course of a plasmodium berghei infection in six different mouse strains. | 1977 | 341557 | |
| the immunological response of cba mice to p. yoelii. ii. the passive transfer of immunity with serum and cells. | cba mice infected with the malaria parasite plasmodium berghei yoelii (p. yoelii) develop a self-resolving infection lasting 15-18 days; on recovery from a primary infection they are immune to further infection. cell and serum transfers from immune to non-immune mice were used to analyse the mechanism of resistance. whereas serum from mice which had recovered from a single infection was ineffective in transferring immunity, hyperimmune serum (from mice repeatedly challenged with p. yoelii) prote ... | 1978 | 342396 |
| demonstration of the role of cytophilic antibody in resistance to malaria parasites (plasmodium berghei) in rats. | this paper reports the results of a study of the nature of the immune response against plasmodium berghei parasites by inbred rats. a macrophage-cytophilic antibody specific for malarial antigens was identified and characterized. detection of the antibody on the macrophage surface was accomplished by the parasite adherence tests and by the indirect fluorescent antibody technique. isolation and purification of the macrophage-cytophilic and opsonic antibodies from hyperimmune rat serum was accompl ... | 1978 | 342408 |
| column separation of plasmodium berghei sporozoites. | 1978 | 342682 | |
| synthesis of pyrimido[5,4-c]quinolines and related quinolines as potential antimalarials. | 3-ethylaminomethyl-2-methyl-4(1h)-quinolone (1a) and its 6-ch3, 6-och3, and 7-cl derivatives were prepared by means of the mannich reaction. conversion to the 4-chloro derivatives and condensation with 3-chloroaniline gave the corresponding 4-(3-chloroanilino) derivatives. cyclization of 4-(3-chloroanilino)-2,6-dimethyl-3-ethyl-aminomethylquinoline (3a) and its 6-och3 derivative with paraformaldehyde gave 1-(3-chlorophenyl)-3,9-dimethyl-3-ethyltetrahydropyrimido[5,4-c]quinoline (4a) and the 9-oc ... | 1978 | 342694 |
| cell mediated and humoral immunity in experimental plasmodium berghei infection. | adoptive passive transfer of immunity to plasmodium berghei infection has been investigated in an inbred strain of swiss mice. the mice were made hyperimmune by repeated passage of 10(3) parasites and subsequent therapy with an antimalarial drug. immune sera and cells obtained from thymus, spleen and peritoneal exudate were transferred to normal animals which were subsequently challenged with standard doses of p. berghei. it was observed that: (a) immune serum in high doses (0.5 ml/mouse) enhanc ... | 1977 | 343309 |
| immunity to plasmodium berghei in rats: reduced protective activity of immune spleen cells when transferred to recently infected rats. | 1978 | 345537 | |
| [morphologic changes in erythrocytes following the penetration and intra-erythrocyte development of plasmodium berghei in the mouse]. | 1977 | 345925 | |
| regional depression of delayed hypersensitivity to sheep erythrocytes in mice infected with plasmodium berghei (nk65). | 1978 | 347045 | |
| amino acid analogs iv:4-fluoroisoleucine. | 4-fluoroisoleucine was produced by ammonolysis of 2-bromo-4-fluoro-3-methylpentanoic acid, which resulted from the bromofluorination of 4-methyl-2-pentenoic acid. it did not inhibit plasmodium berghei in mice at 640 mg/kg and was not toxic to the animals. the fluoroamino acid inhibited aspergillus niger, trichoderma viride, myrothecium verrucaria, trichophyton mentagrophytes, and mucor mucedo in czapek solution agar at a concentration between 10(4) and 10(3) microgram/ml. growth of escherichia ... | 1978 | 347050 |
| immunopathological studies of plasmodium berghei berghei-infected mice: effect of cyclophosphamide. | 1978 | 347101 | |
| fading of malaria immunity in mice. | fading of immunity in swiss and c3h/stz mice was progressive, and related to both, the interval elapsed since the last challenge infection and survival of parasites. in both mouse strains the proportion of mice that remained immune to challenge decreased with increasing fading periods. moreover, a shift from delayed mortality to a normal course of infection as seen in non-immune controls was observed in c3h/stz mice. early parameters of fading were increasing peak parasitaemias after challenge i ... | 1978 | 347653 |
| resolution of antimalarial agents via complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid. | the resolution of several antimalarial agents via pi-complex formation with alpha-(2,4,5,7-tetranitro-9-fluorenylideneaminooxy) propionic acid (tapa) is reported. since this represents the first use of this agent for the resolution of amines, some details of the separations are presented. the method proved successful for resolving weakly alkaline amines that did not form stable salts with common resolving acids, highly insoluble amines that did not form soluble salts with usual resolving acids, ... | 1978 | 349156 |
| folate antagonists. 10. synthesis and antimalarial effects of 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides. | various 6-[[(aryl and aralkyl)amino]methyl]-2,4-pteridinediamines and their 8-oxides have been synthesized for antimalarial evaluation. condensation of 3-amino-6-(bromomethyl)-2-pyrazinecarbonitrile 4-oxide (v) with the appropriately substituted amine afforded a series of 3-amino-6-[[(aryl and aralkyl)amino]methyl]-2-pyrazinecarbonitrile 4-oxides vi. deoxygenation gave the corresponding pyrazines vii. cyclization of vi and vii with guanidine then produced the desired 6-(aminomethyl)-2,4-pteridin ... | 1978 | 349157 |
| folate antagonists. 11. synthesis and antimalarial effects of 6-[(aryloxy- and arylthio-)methyl]-2,4-pteridinediamines and -pteridinediamine 8-oxides. | condensation of 3-amino-6-(bromomethyl)-2-pyrazinecarbonitrile 4-oxide with 4-chlorophenol gave 3-amino-6-[(4-chlorophenoxy)methyl]-2-pyrazinecarbonitrile 4-oxide (1), which was deoxygenated to obtain the de-n-oxide 4. cyclization of 4 and 1 produced 6-[(4-chlorophenoxy)methyl]-2,4-pteridinediamine and the 8-oxide, respectively. 6-[(arylthio)methyl]-2,4-pteridinediamines and their 8-oxides were produced analogously. controlled oxidation of the former gave the anticipated sulfoxide 12 and sulfone ... | 1978 | 349158 |
| the chemotherapy of rodent malaria, xxix dna relationships within the subgenus plasmodium (vinckeia). | the relationships between rodent malarias were examined by means of dna buoyant density determinations and dna--dna hybridization data. current views of the existence in this group of four species: plasmodium berghei, p. yoelli, p. vinckei and p. chabaudi were confirmed. the identity of two chloroquine-resistant lines derived from p. berghei n strain was established. one of these, the ns line, was found to be a subspecies of p. yoelii; the implications of this finding are discussed. | 1978 | 350169 |
| the chemotherapy of rodent malaria, xxx. the enigmas of the 'ns lines' of p. berghei. | 1978 | 350170 | |
| plasmodium berghei: biological variation in immune serum-treated mice. | 1978 | 350601 | |
| plasmodium berghei infection in pregnant rats: effects on antibody response and course of infection in offspring. | the effects of primary, patent plasmodium berghei infection in sprague-dawley rats during pregnancy upon the course of infection and the humoral antibody response to malaria in their offspring were examined. malaria specific antibody determined by an indirect fluorescent antibody test correlated well with the parasitologic profiles of each experimental group. utilization of foster mother groups indicated passive transfer of protective antibody through milk. evidence for in utero sensitization by ... | 1978 | 351159 |
| sporozoites of rodent and simian malaria, purified by anion exchangers, retain their immunogenicity and infectivity. | sporozoites of rodent malaria, plasmodium berghei, and simian malaria, plasmodium knowlesi and plasmodium cynomolgi, were partially separated from mosquito debris and microbial contaminants by passage of anopheles material through a deae-cellulose column. in addition to eliminating most of the contaminants (80-90%), this simple technic has made it possible to recover rapidly large numbers of viable sporozoites (55-75% yield), which have retained their infectivity, immunogenicity, and capacity to ... | 1978 | 351177 |
| autoimmune and polyclonal b cell responses during murine malaria. | 1978 | 351426 | |
| studies on enzyme variation in the murine malaria parasites plasmodium berghei, p. yoelii, p. vinckei and p. chabaudi by starch gel electrophoresis. | electrophoretic variation of the enzymes glucose phosphate isomerase, 6-phosphogluconate dehydrogenase, lactate dehydrogenase and glutamate dehydrogenase (nadp-dependent) has been studied in the african murine malaria parasites plasmodium berghei, p. yoelii, p. vinckei and p. chabaudi and their subspecies. horizontal starch gel electrophoresis was used throughout. the number of isolates examined in each subspecies varied from 1 (p. y. nigeriensis) to 24 (p. c. chabaudi). extensive enzyme variati ... | 1978 | 351525 |
| [effect of drought on antimalarial immunity]. | 1978 | 351558 | |
| the chemotherapy of rodent malaria, xxxi. the effect of some metabolic inhibitors upon chloroquine-induced pigment clumping (cipc) in plasmodium berghei. | the effect of metabolic inhibitors upon chloroquine-induced pigment clumping in intraerythrocytic plasmodium berghei was studied in vitro. oligomycin and venturicidin competitively inhibit the process with 'ki' values of 0.18 and 0.41 mumol/l. dccd, an agent thought to act upon a mitochondrial site close to that affected by oligomycin and venturicidin, causes pigment clumping in the absence of chloroquine ('km' value 4.7 mumol/l). it is suggested that, after being concentrated in the cytoplasm b ... | 1978 | 352284 |
| changes in the hamster liver after experimental infection with schistosoma intercalatum. an ultrastructural study. | syrian hamsters were exposed to cercariae of schistosoma intercalatum. after 70 days, their livers were fixed by vascular perfusion and samples of liver tissue were studied by the electron microscope. lesions consisted predominantly of mature egg granulomas, with some in earlier stages of development. the cells involved in both types of lesion are described together with their relation to the egg and the surrounding liver tissue. only minor abnormalities were seen in the tissue distant from the ... | 1978 | 352285 |
| [indirect immunofluorescence in malaria associated with pregnancy in the senegalese woman]. | 1978 | 352555 | |
| polyclonal b-cell activation during rodent malarial infections. | the numbers of 'background' plaque-forming cells (pfc) secreting igm specific for either sheep erythrocytes or horse erythrocytes were found to be elevated in the spleens of balb/c mice during plasmodium berghei and p. yoelii infection. 'background' pfc numbers were similarly elevated in the spleens of uninfected mice injected with high speed supernatants of lysates of parasitized red blood cells. the active factor (or factors) in the supernatants was (were) non-dialysable and stable at 56 degre ... | 1978 | 352584 |
| role of the surface coat in in vitro attachment and phagocytosis of plasmodium berghei by peritoneal macrophages. | evidence is presented to indicate that plasmodium berghei merozoites, but not trophozotites, have an antiphagocytic capsule. the capsule appears to form around the developing merozoties of the schizont in the parasitophorous vacuole. serum from animals immune to p. berghei reacts with this capsule. after reaction with immune serum, the antiphagocytic action of the capsule is lost. by the process of binding serum protein, the capsule becomes electron dense and can be readily visuallzed as the sur ... | 1978 | 352960 |
| a new class of antimalarial drugs: derivatives of benzothiopyrans. | a series of substituted benzothiopyrans was synthesized and examined for antimalarial activity. some were found to be active and curative at dose levels of 160--360 mg/kg against plasmodium berghei in mice. afew observations concerning structure-activity relationships were made. the benzothiopyrans were prepared by treatment of either the gem-dichloro- or the thionothioflavone intermediate with various primary amines. the thionothioflavone intermediates were made from thioflavones. condensation ... | 1978 | 353282 |
| survival of parasites in mice immunized against plasmodium berghei. | the rodent malaria parasite plasmodium berghei may survive im immunized swiss and c3h/stz mice for a considerable period of time. despite considerable differences in the observed survival time in animals of a given strain, a general, strain specific pattern is observed. parasites generally survive longer in swiss than in c3h/stz mice. in some of the swiss mice parasites survived throughout the experimental period, whereas in the others restricted survival was observed, possibly reflecting geneti ... | 1978 | 354146 |
| malaria vaccine: the effect of sporozoite-induced immunity on exo-erythrocytic stages. | 1978 | 354537 | |
| malaria immunity and premunition in a plasmodium berghei mouse model. | 1978 | 355189 | |
| infectivity and immunogenicity of plasmodium berghei. | 1978 | 355190 | |
| plasmodial antigens exposed on the surface of infected reticulocytes: their role in induction of protective immunity in mice. | 1978 | 355192 | |
| cellular changes in the bone marrow of plasmodium-berghei-infected mice. | 1978 | 355193 | |
| lymphoblast transformation in rats convalescent from infection with plasmodium berghei. | 1978 | 355194 | |
| speculation on the use of adoptive immunity in malarial vaccination. | 1978 | 355195 | |
| studies on the role of antibodies against sporozoites in plasmodium berghei malaria. | 1978 | 355196 | |
| clomerulopathy in mice infected with plasmodium berghei: induction of an autoimmune process. | 1. apparently a living, metabolizing parasite is required to induce the formation of autoantibodies. 2. it seems unlikely that immune complexes of the first type, i.e., positive for plasmodial antigens, are responsible for the induction of autoantibodies, as the transferred malarious plasma (group b) also contained that type of immune complex, but did not induce the formation of the second type of complex. 3. although a deregulation of the immunocompetent system will occur in animals with a high ... | 1978 | 355198 |
| immune complexes in the lungs of mice infected with plasmodium berghei. | 1978 | 355199 | |
| histo- and immunopathology of a malaria (plasmodium berghei) infection in mice. | 1978 | 355200 | |
| lymphocyte trapping and malaria in plasmodium-berghei-infected mice. | 1978 | 355201 | |
| specific arming of macrophages and the microarchitecture of the spleen. | 1978 | 355202 | |
| a rapid method for concentrating spleen-derived schizonts in plasmodium berghei malaria. | 1978 | 355615 | |
| [alteration in the virulence of plasmodium berghei yoelii for white mice by passage through golden hamsters and by the in vitro exposure to the serum of these animals]. | 1978 | 355826 | |
| splenic transposition with ligation of the vascular pedicle in rodents. immunological consequences. | by splenic subcutaneous transposition and ligation of the vascular pedicle, the direct relation spleen-liver was interrupted in rodents infected with malaria. it was demonstrated that in this situation detoxification of the liver and recovery from malaria was evidently hampered by the lack of a direct splenic cell supply, due to retardation of the homing and differentiation in the spleen of precursors of immunologically competent cells. in the presence of blood-borne antigens and/or hepatotoxins ... | 1978 | 357154 |
| changes in transaminase activity in plasma and liver of albino mice infected with plasmodium berghei. | 1978 | 357282 | |
| erythrocyte surface: novel determinant of drug susceptibility in rodent malaria. | to study the role of the erythrocyte membrane in the process of chloroquine accumulation, surface polypeptides were digested with a nonspecific protease from streptomyces griseus. this treatment activated a saturable process of chloroquine accumulation with an affinity and a specificity similar to those of mouse erythrocytes infected with plasmodium berghei cs (chloroquine susceptible). studies of competitive inhibitors of chloroquine accumulation yielded the following approximate values for k(i ... | 1978 | 358916 |
| spleen cell changes during fatal and self-limiting malarial infections of mice. | changes in the proportions and total numbers of splenic thy-1.2+ cells, ig+ cells and normoblasts were analysed during fatal plasmodium berghei and non-fatal p. yoelii infections in mice. thy-1.2+ and ig+ cells were identified by rosetting techniques, and normoblasts by morphological criteria. the splenomegaly observed during these infections was found to be caused mainly by proliferation of normoblasts. an early increase in the numbers of thy-1.2+ and ig+ cells was detected in both infections, ... | 1978 | 359462 |
| xanthine oxidase in rodent malaria. | 1978 | 359466 | |
| [ionic etching of erythrocytes by means of a cathodic evaporator. iii. --application to mouse erythrocytes infested by plasmodium berghei (author's transl)]. | 1978 | 360955 | |
| [congenital malaria in mice and adenosine triphosphate (atp)]. | 1978 | 361005 | |
| plasmodium berghei adoptive transfer and immunosuppression of immunity in allogenic neonates. | outbred female rats were hyperimmunized with plasmodium berghei and mated to produce progeny. spleen cells from the immunized rats and from normal control mothers were adoptively transferred to their 48 hr old neonates. some neonates from immune mothers were fostered to normal mothers and vice versa. weanling rats were challenged 35 days after birth with plasmodium berghei; immune and normal litters which had not received cells were also challenged at the same time. rats which had received immun ... | 1978 | 361317 |
| depressed splenic t lymphocyte numbers and thymocyte migratory patterns in murine malaria. | 1978 | 362425 | |
| lack of chloroquine inhibition of erythrocytic glucose-6-phosphate dehydrogenase in malaria (plasmodium berghei). | 1978 | 363079 | |
| immunosuppression using triamcinolone acetonide, in 17-x and nyu-2 strains of plasmodium berghei in mice. | 1978 | 363998 | |
| t cell function during fatal and self-limiting malarial infections of mice. | 1978 | 365359 | |
| plasmodium berghei: infective exoerythrocytic schizonts in primary monolayer cultures of rat liver cells. | 1978 | 365559 | |
| plasmodium berghei: preparation of rat hepatic cell suspensions that include infective exoerythrocytic schizonts. | 1978 | 365560 | |
| plasmodium berghei: energy metabolism of sporozoites. | 1978 | 365562 | |
| host defenses in murine malaria: induction of a protracted state of immunity with a formalin-killed plasmodium berghei blood parasite vaccine. | random-bred mice were immunized with a nonliving antigen prepared from mixed-blood forms of plasmodium berghei, strain nyu-2, in combination with corynebacterium parvum and/or living bcg. a high proportion of intravenously immunized mice survived virulent challenge, but subcutaneous vaccination was less effective. vaccinated mice developed a patent infection after challenge similar to that observed in normal controls. however, between days 12 to 20 postchallenge, infections in some vaccinated mi ... | 1978 | 365770 |
| chronic malarial infection of mice: a comparison of single and multiple infections with plasmodium berghei following p. yoelii. | chronic malarial infection was induced in two groups of balb/c mice by injection of plasmodium yoelii followed by either one or repeated injections of p. berghei. both groups showed a continuing but fluctuating splenomegaly, and a considerably increased reticulocyte count which also varied regularly, over a period of six months. during this time many mice had a very low grade parasitaemia demonstrable by subinoculation of blood into uninfected recipients. mice infected with p. yoelii alone did n ... | 1978 | 366816 |
| removal of leucocytes from red cells in plasmodium berghei-infected mouse blood and purification of schizont-infected cells. | 1978 | 367300 | |
| the protective effect of endogenous interferon in mouse malaria, as demonstrated by the use of anti-interferon globulins. | both death rate and percentage of parasitized erythrocytes in mice infected with plasmodium berghei were enhanced by injections of anti-interferon globulins. as, in the same time, parasite-induced interferon was neutralized by these globulins, it can be concluded that endogenous interferon plays an important inhibiting role during parasitic diseases, such as malaria, as it has been previously demonstrated in many virus infections. | 1978 | 367460 |
| immunofluorescent staining of exoerythrocytic schizonts of plasmodium berghei in fixed liver tissue with stage-specific immune serum. | 1978 | 368305 | |
| [continuous axenic culture of mammalian plasmodia. i. plasmodium berghei]. | 1977 | 368933 | |
| a susceptible and refractive strain of anopheles atroparvus van thiel to infection with plasmodium berghei berghei. | 1977 | 369264 | |
| labelling of plasmodium berghei during sporogony. | 1977 | 369268 | |
| [in vivo formation of myelin-like forms in mouse erythrocytes infested by plasmodium berghei (author's transl)]. | 1978 | 369437 | |
| changes in serum, liver, fat pad and thymus lipid levels in adult rats infected with plasmodium berghei. | 1977 | 370086 | |
| antimalarials. 4. trichloronaphthalene amino alcohols. | an improved procedure for the synthesis of naphthalene amino alcohols is described. four new compounds were prepared and tested by rane laboratories for activity vs. plasmodium berghei in mice. all compounds were active, the most active being 1-[3-(4-chlorophenyl)-5,7-dichloro-1-naphthyl]-3-(di-n-butylamino)propanol hydrochloride (16b). structure--activity relationships between the naphthalene and quinoline isosteres are discussed. | 1979 | 370389 |
| chloroquine resistance in malaria: accessibility of drug receptors to mefloquine. | the process of mefloquine accumulation was studied in mouse erythrocytes infected with either plasmodium berghei cs (chloroquine susceptible) or p. berghei cr (chloroquine resistant). in both cases, mefloquine was accumulated by a saturable process with an apparent dissociation constant of 2.5 x 10(-6) m and an apparent maximal capacity of 700 mumol per kg of erythrocyte pellet; uninfected mouse erythrocytes accumulated more than half as much mefloquine as infected erythrocytes. the process of a ... | 1979 | 371544 |
| the role of platelets in infections. i. observations in human and murine malaria. | the interaction between platelets and microorganisms may be underestimated. our in vivo studies support a direct role of thrombocytes in malarial infections. we have found intrathrombocytic parasites of plasmodium vivax (in 10% of men naturally infected) and p berghei (in 53% of mice experimentally infected); these were both merozoites and trophozoites. neither the mechanism of parasitization (whether by active penetration or by phagocytosis) nor the outcome of this phenomenon is known. however, ... | 1979 | 371580 |
| separation of plasmodium berghei-parasitized rat erythrocytes by means of carrier-free electrophoresis. | a carrier-free electrophoresis apparatus was used to isolate rat erythrocytes parasitized with plasmodium berghei. the region of high electrophoretic mobility yielded noninfected erythrocytes, whereas that of low electrophoretic mobility yielded erythrocytes infected with viable parasites. over 98% purity of parasitized erythrocytes was obtained when blood at an advanced stage of parasitaemia was used. merozoite-rich fractions were also observed. this continuous one-step separation method should ... | 1979 | 371849 |
| quantitative structure-activity relationships in 1-aryl-2-(alkylamino)ethanol antimalarials. | a quantitative structure-activity relationship has been formulated for 646 antimalarials acting against p. berghei in mice. the equation developed has 14 terms, 9 of which are indicator variables. the correlation coefficient for the qsar is 0.898 and the standard deviation is 0.309. the antimalarials are all arylcarbinols of the type x-archohch2nr1r2. sixty different aryl structures, including a variety of heterocyles, are contained in the study. the most important determinate of activity is fou ... | 1979 | 372527 |
| the ribosomes of plasmodium berghei: isolation and ribosomal ribonucleic acid analysis. | ribosomes and high molecular weight ribosomal ribonucleic acid (rrna) from the blood stages of plasmodium berghei parasites were studied in preparations free from host ribosome contamination. purified malarial ribosomes were isolated in high yield from a population of ultrastructurally intact, viable parasites by hypertonic lysis with triton x-100 and differential centrifugation. these ribosomes were shown to be derived from active polysomes and could be dissociated into subunits by puromycin-0. ... | 1978 | 372893 |
| effect of temperature and clofibrate on plasmodium berghei infection in mice. | parasitemia counts established that 22 degrees c-acclimated mice subjected to cold exposure for a short time (-35 degrees c for 30 min) during plasmodium berghei infection had significantly higher parasitemia levels than parasitized mice continuously housed at 22 degrees c. parasitized 5 degrees c-acclimated mice also demonstrated higher parasitemia levels than parasitized 22 degrees c-acclimated mice. there was no correlation between plasma free fatty acid (pffa) concentration and parasitemia i ... | 1979 | 373470 |
| host defenses in murine malaria: successful vaccination of mice against plasmodium berghei by using formolized blood parasites. | infections of normal icr mice with the nyu-2 strain of plasmodium berghei (pb) are uniformly fatal. however, a proportion of mice that have been vaccinated with a formalin-killed antigen prepared from the blood stages of pb survive an otherwise lethal challenge. such immunity is not induced by immunization with normal mouse erythrocytes. the level of acquired anti-malarial immunity is related to the size and number of doses of antigen, and intravenous injection is superior to the subcutaneous ro ... | 1979 | 373471 |
| plasmodium berghei: correlation of in vitro erythrophagocytosis with the dynamics of early-onset anemia and reticulocytosis in mice. | 1979 | 374106 | |
| experimental studies of schistosomal pigment from schistosoma japonicum. | the schistosomal and malarial pigments were distinguishable before and after extraction from the host liver. presence of iron in both pigments was ascertained by the elemental x-ray analysis. histochemically, however, schistosomal pigment was similar to that of malarial pigment. | 1979 | 374107 |
| immunosuppression in murine malaria. iii. induction of tolerance and of immunological memory by soluble bovine serum albumin. | the primary antibody response to alumadsorbed bsa was depressed when initiated during low-grade chronic plasmodium berghei malaria in mice, as previously reported during acute p.y. yoelii infection. induction of immunological memory by soluble polymerized bsa was abolished in both infections; in infected hosts this normally immunogenic stimulus resulted in partial tolerance. in contrast to the depression of immune response, neither infection interfered with the induction of low-zone tolerance by ... | 1979 | 374257 |
| phenazines with two cationic side chains as potential antimalarials. | 1,9-phenazine-bis(dialkylaminocarboxamides) were prepared for screening as potential antimalarials. no significant activity against plasmodium berghei was observed. the phenazine targets were prepared from 1,9-phenazinedicarboxylic acid by standard methods. the reaction between 1,9-phenazinedicarboxylic acid and thionyl chloride in the presence of dimethylformamide unexpectedly gave 4-chloro-1,9-phenazinedicarbonyl chloride. | 1979 | 374708 |
| [further observations of the course of plasmodium berghei infection in the mouse]. | invasion of immature and mature erythrocytes by merozoites of plasmodium berghei seems to obey the following rules: merozoites prefer unparasitized immature erythrocytes. multiple infections of immature erythrocytes occur in conditions of high merozoite production and low concentration of unparasitized immature erythrocytes, when frequently repeated contacts between merozoites and unparasitized or freshly parasitized immature erythrocytes become increasingly probable. mature erythrocytes are inv ... | 1979 | 375509 |
| protection of mice against plasmodium and babesia infections: attempts to raise host-protective sera. | in an attempt to generate large numbers of mice resistant to plasmodium berghei and babesia rodhaini to be used as donors of antibody-secreting cells for hybridoma production, various methods of inducing resistance to repeated challenge with infected blood cells have been explored. although results of independent experiments varied markedly, prior injection of cba/m mice with bcg, and prior infection of balb/c mice with plasmodium yoelii, were found to be manipulations capable of inducing resist ... | 1978 | 375903 |
| plasmodium berghei: effect of antithymocyte serum on induction of immunity in the mouse. | 1979 | 376327 | |
| intravascular clearance of parasitized erythrocytes in rodent malaria. | little is known about host defense mechanisms responsible for protective immunity in malaria. the intravascular location of the infection suggested that removal of parasitized erythrocytes by reticuloendothelial organs might be important. to study this possibility, we examined the clearance of (51)crlabeled plasmodium berghei-infected erythrocytes in rats. infected erythrocytes were removed more rapidly from circulation than homologous uninfected erythrocytes. the rate of clearance of infected c ... | 1979 | 376554 |
| circulating and tissue-bound immune complex formation in murine malaria. | immune complex formation during plasmodium berghei infection of of1 mice was investigated. circulating immune complexes (cic) were detected by the clg-binding assay and the conglutinin-binding solid-phase assay in lethal or drug-limited infections. cic appeared on day 9 of infection, peaked on day 11, and disappeared only after complete cure of the infection. analysis of the immune complexes detected by the clq-binding assay revealed the following characteristics: sedimentation coefficients of 1 ... | 1979 | 376733 |
| hemolymph of anopheles stephensi from uninfected and plasmodium berghei-infected mosquitoes. 2. free amino acids. | determinations were made of free amino acids in hemolymph collected from adult female anopheles stephensi mosquitoes. the hemolymph first was fractionated by extraction and precipitation procedures, after which qualitative determinations of free amino acids were made by high voltage thin layer electrophoresis, and thin layer chromatography. subsequent quantitative determinations were made with an automatic amino acid analyzer. the concentration of total free amino acids in the hemolymph rose 60- ... | 1979 | 376812 |
| hemolymph of anopheles stephensi from noninfected and plasmodium berghei-infected mosquitoes. 3. carbohydrates. | determinations were made of carbohydrates in hemolymph collected from adult female mosquitoes (anopheles stephensi). first the hemolymph was fractionated by extraction and precipitation procedures, after which qualitative and quantitative determinations of carbohydrates were made by thin layer chromatography. the most abundant sugars found in the hemolymph were glucose and trehalose, though maltose, glucuronic acid, and inositol could be found after the mosquitoes took blood meals. after the mos ... | 1979 | 376818 |
| isolation of plasmodium berghei by hemolysin lysis of infected erythrocytes and evidence for a parasite hexokinase. | a rapid and simple procedure has been developed for the isolation of plasmodium berghei parasites from infected-mouse erythrocytes employing the heat stable hemolysin produced by pseudomonas aeruginosa. using parasites isolated by this method, the presence of a parasite specific hexokinase has been demonstrated, providing an explanation for the increased glucose consumption observed with infected cells. enzyme assays and serology were employed in determining the purity and yield of purified para ... | 1979 | 376819 |
| 2-acetylpyridine thiosemicarbazones. 1. a new class of potential antimalarial agents. | based on the antimalarial properties observed for 2-acetylpyridine 4-phenyl-3-thiosemicarbazone (1), an extensive series of related thiosemicarbazones was prepared and tested against plasmodium berghei in mice. screening results indicated that the presence of the 2-pyridylethylidene group was critical and that certain phenyl, benzyl, phenethyl, or cycloalkyl groups at n4 of the thiosemicarbazone moiety also contribute to antimalarial activity. | 1979 | 376848 |
| dipeptides of o-methyl-l-threonine as potential antimalarials. | l-leucyl-o-methyl-l-threonine, o-methyl-l-threonyl-l-leucine, and o-methyl-l-threonyl-o-methyl-l-threonine were prepared and compared with o-methyl-l-threonine and l-leucine for antimalarial activity against plasmodium berghei in mice. o-methyl-l-threonine significantly prolonged survival time at doses of 160, 320, and 640 mg/kg. o-methyl-l-threonyl-o-methyl-l-threonine was less active, significantly prolonging survival time only at 640 mg/kg. l-leucine, as well as the other two dipeptides, exhi ... | 1979 | 376849 |
| immunosuppression induced by plasmodium berghei and p. chabaudi infections in mice. | 1978 | 377186 | |
| spleen plays major role in removal from bloodstream of malaria-infected rbcs. | 1979 | 377364 |