Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| thoracoscopy in children. | dissatisfied with standard techniques for pulmonary diagnosis in children, we have evaluated the usefulness of thoracoscopy for diagnosis of intrathoracic pathology. between july 1, 1975, and may 1, 1978, 65 thoracoscopy procedures have been performed in 57 children at the university of florida. thirty-four procedures were performed in immunosuppressed patients to rule out pneumocystis carinii pneumonia. twenty of these patients were proven to have pneumocystis pneumonia, a diagnostic accuracy o ... | 1979 | 311621 |
| [a study of pneumocystis carinii pneumonia (author's transl)]. | 1979 | 311866 | |
| pneumocystis carinii pneumonia--(a case report). | 1979 | 312276 | |
| [percutaneous needle aspiration biopsy for pneumocystis carinii pneumonia (author's transl)]. | 1979 | 312349 | |
| [cellular and humoral immunity in pneumocystis carinii pneumonia in a 4-month-old infant with congenital heart defect]. | 1979 | 313037 | |
| clinical characteristics of pneumocystis carinii pneumonia. | 1979 | 313176 | |
| experimental pneumocystis carinii pneumonia in different strains of cortisonized mice. | pneumocystis carinii pneumonia was produced in eight different strains of mice by the administration of corticosteroids, low (8%)-protein diet, and tetracycline in the drinking water. heavier degrees of p. carinii infection were most consistently found in c3h/hen mice; intermediate levels occurred in balb/c ann, c57bl/6n, b10.a(2r), akr/j, and swiss webster mice; lighter degrees were found in dba/2n and dba/ij mice. histopathologically, p. carinii organisms were morphologically indistinguishable ... | 1979 | 313907 |
| pneumocystis carinii pneumonia as the presenting infection in congenital hypogammaglobulinemia. | 1979 | 314502 | |
| pneumocystis carinii pneumonia: a study of 22 postmortem cases at chulalongkorn hospital. | 1979 | 314966 | |
| pneumocystis carinii pneumonia in children. | previous descriptions of pneumocystis carinii pneumonia have emphasized a variety of radiographic patterns which most often apply to advanced disease. we reviewed the chest roentgenograms of children taken at or just after the onset of clinical symptoms. subtle but definite abnormalities of pulmonary vessels, hila, parenchyma, and aeration were observed. appreciation of these early changes is necessary to initiate prompt treatment. the role of lung biopsy and the histologic features of these pat ... | 1979 | 315614 |
| pneumocystis carinii pneumonia: epidemiology in japan, and cyst concentration method. | pneumocystis carinii pneumonia has been markedly increasing recently in japan. most cases are seen after receiving anti-cancer and immunosuppressive therapy against their underlying diseases. no cases have been found in undernourished or premature infants. the authors proposed a new method which can concentrate the cysts efficiently from the human and animal lungs, and express the density of infection quantitatively at the same time. this method will especially be valuable to demonstrate the org ... | 1979 | 315677 |
| limited effect of trimethoprim-sulfamethoxazole prophylaxis on pneumocystis carinii. | trimethoprim-sulfamethoxazole has been proven effective in the treatment and prevention of pneumocystis carinii pneumonitis in lower animals and humans. how effective the drug combination is in eradicating p. carinii from the host is not known. the immunosuppressed rat model was used to determine whether or not trimethoprim-sulfamethoxazole effectively eradicated the organism. animals treated with trimethoprim-sulfamethoxazole for as long as 6 weeks were then placed in individual isolator cages, ... | 1979 | 315754 |
| refractory pneumocystis carinii infection in chronic granulomatous disease: successful treatment with granulocytes. | pneumocystis carinii pneumonia developed in an 11-year-old girl with chronic granulomatous disease who had normal cellular and humoral immunity. the patient remained febrile during treatment with sulfamethoxazole-trimethoprim and pentamidine but became afebrile when treated with a series of 12 granulocyte transfusions combined with sulfamethoxazole-trimethoprim. in addition to documenting p carinii infection in chronic granulomatous disease our findings suggest that granulocyte transfusions may ... | 1979 | 316128 |
| treatment of pneumocystis carinii pneumonia with trimethoprim-sulfamethoxazole and pentamidine: efficacy and toxicity. | a 39-year-old man with pneumocystis carinii pneumonia responded poorly to oral trimethoprim-sulfamethoxazole (tmp-smx) therapy, despite excellent serum concentrations of the drug. he developed severe thrombocytopenia when pentamidine was added to the regimen. this case illustrates problems of drug efficacy and toxicity in the treatment of p carinii pneumonia and suggests caution in the use of tmp-smx and pentamidine in combination. | 1979 | 316194 |
| cultivation of pneumocystis carinii with wi-38 cells. | pneumocystis carinii has been successfully cultured with wi-38 human embryonic lung fibroblasts. inoculum was obtained from infected lungs of cortisone-treated sprague-dawley rats. trophozoites reached peak numbers between days 4 and 8 and grew in two subcultures, but then proliferation ceased. if primary cultures were harvested and new medium were added, a second and sometimes a third harvest could be obtained. cell monolayers were not destroyed. after growth of the initial inoculum had ceased, ... | 1979 | 316433 |
| [radiographic manifestations of pneumocystis carinii pneumonia (author's transl)]. | 1979 | 316467 | |
| [value of needle biopsy in the diagnosis of pneumocystis carinii pneumonia]. | 1979 | 316889 | |
| [congenital syphilis, malnutrition and pneumocystis carinii pneumonia]. | a korean child aged six months with congenital syphilis and malnutrition developed pneumocystis carinii pneumonia. he recovered after treatment with trimethoprin/sulphamethoxazole with assisted ventilation. there was no evidence of immune deficiency. the role of congenital syphilis and malnutrition predisposing the baby to this infection is discussed. | 1979 | 317242 |
| pneumocystosis: a chronic respiratory distress syndrome in the dog. | pneumonia caused by pneumocystis carinii in two unrelated miniature dachshunds is reported. the clinical findings, gross- and histopathology and some diagnostic transmission and scanning electron microscopic features of the condition are described. although pneumocystosis has been reported from a human and a domestic goat in the republic of south africa, these are probably the first reported cases of the canine disease in this country. | 1979 | 317832 |
| [pneumocystis carinii pneumonia in chronically immunosuppressed patients. apropos of 33 cases]. | the availability of drugs that are active against pneumocystis carinii has renewed interest in and underlined the difficulties of the early diagnosis pneumocystis pneumonia. a retrospective study of 33 cases was undertaken to define the optimal management. it is necessary to take into consideration the high mortality of the untreated condition and the risks of investigation and of treatment. pneumocystis pneumonia affects only those patients who are immunologicaly incompetent, particularly those ... | 1979 | 318016 |
| [monitoring of side effects in patients treated with corticosteroids of cytotoxic drugs (author's transl)]. | side effects have to be monitored carefully in all patients receiving drugs profoundly affecting their metabolism. corticosteroids produce the well-known cushing's syndrome. children rarely develop gastric ulcers or disturbances of haemostasis. if steroids are administered for more than one year, the eyes have to be examined for signs of cataract. rarely, the pseudotumor cerebri syndrome (increased intracranial pressure) may be observed. a monitoring schedule adapted from adult medicine for paed ... | 1977 | 320459 |
| the laboratory diagnosis of pneumocystis carinii pneumonia. | in the diagnosis of pneumocystis carinii infection in man, rather exacting methods of staining must be used for the organism to be visualized in lung tissue. techniques for sample collection, which range from open lung biopsy to endobronchial brush methods or collection of sputum, are discussed. recent advances in the serologic diagnosis and in the culture of the organism are also covered. | 1977 | 326727 |
| pneumocystis carinii pneumonia. | 1977 | 337137 | |
| the interaction in vitro of pneumocystis carinii with macrophages and l-cells. | a model was developed for studying the interaction between pneumocystis, rat-derived cells, and humoral factors. pneumocystis were obtained in large quantity by bronchial lavage of steroid-treated rats. the trophozoite was the predominant form obtained, and it could readily be recognized by phase contrast microscopy. organisms maintained a typical morphology for at least 3 days in culture, and 10-20% took up radiolabeled nucleotides. pneumocystis readily adhered to cell surfaces in a similar man ... | 1978 | 342665 |
| [pneumocystis carinii pneumonia]. | a study is carried out in 8 infants with a diagnosis of pneumocystis carinii pneumonia which was established through the study of histologic lung sections, and a microscopic study of protozoas. the following are some of the factors predisposing to this disease: prematurity, significant denutrition, primary immunodeficiencies, extended use of antibiotics, malignancies, and immunosuppressive treatments. | 1977 | 354646 |
| infectious complications of human bone marrow transplantation. | infections are an almost inevitable complication of human bone marrow transplantation and account for the majority of deaths in transplant recipients. even prior to the initiation of the transplantation procedure, patients may present with infections complicating previously unsuccessful chemotherapy for hematological malignancy or aplastic anemia. nevertheless, these pre-transplantation infections should not exclude the possibility of bone marrow transplantation if they can be successfully contr ... | 1979 | 368507 |
| uptake and degradation of pneumocystis carinii by macrophages in vitro. | pneumocystis carinii organisms, isolated from lungs of rats with glucocorticoid-induced pneumocystosis, were ingested and degraded in vitro by alveolar and peritoneal macrophages obtained from healthy rats and mice. uptake of the organisms was inhibited at 4 degrees c and by treatment of macrophages with iodoacetate. neither uptake nor degradation was inhibited by pretreatment of macrophages with hydrocortisone sodium phosphate in vitro. although peritoneal macrophages of any age in vitro were c ... | 1978 | 369410 |
| thoracoscopy. early diagnosis of interstitial pneumonitis in the immunologically suppressed child. | interstitial pneumonitis in immunosuppressed patients demands prompt diagnosis and treatment. in an effort to achieve a simple yet highly accurate method of diagnosis, we have evaluated the usefulness of thoracoscopic examination. twenty-seven procedures have been performed in 24 patients between the ages of 17 months and 18 years. all patients were immunosuppressed, most for treatment of malignant processes. all procedures have been performed under anesthesia with intravenously administered ket ... | 1979 | 369778 |
| trimethoprim-sulfamethoxazole in the united states. | after approximately 5 years of clinical use in great britain and other european countries, trimethoprim-sulfamethoxazole in fixed-dose combination was introduced into the united states in 1973. as a result of sequential blockade in the biosynthesis of tetrahydrofolic acid, the antimicrobial activity of the combination exceeds that of either agent alone. although the drug is approved for use in only chronic urinary-tract infection, otitis media, shigellosis, and pneumocystis carinii pneumonia, ma ... | 1979 | 382938 |
| effect of trimethoprim-sulfamethoxazole on hematological recovery after total body irradiation and autologous marrow infusion in dogs. | to test the effect of the combination of trimethoprim-sulfamethoxazole (tmp-smx) on hematological recovery after bone marrow transplantation, dogs were conditioned with 1,200 r total body irradiation and then infused with autologous marrow. twenty dogs were given tmp-smx at doses equivalent to 10, 20, or 40 mg tmp/kg/day beginning on the day of marrow infusion and continued until the granulocyte count reached 10(3)/mul; in addition, one-half of the dogs received methotrexate, 0.4 mg/kg on days 1 ... | 1979 | 386587 |
| pneumocystis carinii pneumonitis: a serological study. | sera from 23 proven or clinically suspected cases of pneumocystis carinii pneumonitis (pcp) in immunosuppressed patients predominantly with acute lymphoblastic leukaemia, and from 91 normal people, were examined for antibody to p. carinii by indirect immunofluorescence. low levels of antibody were found in 51 of 91 normal people and elevated or rising titres of antibody in 18 out of 21 cases from whom paired or serial convalescent sera could be obtained. | 1979 | 389956 |
| the value of pneumocystis carinii antibody and antigen detection for diagnosis of pneumocystis carinii pneumonia after marrow transplantation. | thirty-three marrow transplant patients with pneumocystis carinii pneumonia were studied to determine the usefulness of antibody and antigen detection in the diagnosis of pneumocystis infection. antibody against p. carinii was present in one half of all patients tested, and changes in antibody titer were not helpful diagnostically. p. carinii antigen was detected by counterimmunoelectrophoresis in the serum of 22 of 28 patients tested. fifteen of 28 patients had antigen detected before or within ... | 1979 | 391111 |
| [listeriosis in the kidney transplant recipients. ten cases (author's transl)]. | three clinical pictures were found in ten cases of listeriosis after renal transplantation: septicemia (six cases), meningo-encephalitis (three cases) and asymtomatic but recurrent bacteriuria (one case). several features demonstrate profound immunologic disturbances in the recipient: close relationship in 9 cases out of 10 between infection and high doses of immunosuppressive drugs, unfavorable outcome of graft (accelerated rejection in 4 cases out of 10) and association in one case with lethal ... | 1979 | 392456 |
| pneumocystis carinii infection: evidence for high prevalence in normal and immunosuppressed children. | using pneumocystis carinii organisms propagated through three passages in embryonic chick epithelial lung cultures, specific antigens and antisera were prepared for use in counterimmunoelectrophoresis and indirect immunofluorescent antibody techniques. these methods proved to be specific and sensitive for the detection of p. carinii antigen and antibody, respectively, in sera, and were applied to the study of cancer patients with p. carinii pneumonitis (pcp), cancer patients without pneumonitis, ... | 1978 | 400818 |
| a special report: four-year study of a boy with combined immune deficiency maintained in strict reverse isolation from birth. | a 4-year study of a boy with combined immune deficiency is presented, and the impact of this disease on various aspects of his growth and development is examined. there is no evidence of immune deficiency in either parent or in the genetic background on the maternal side. three children of a brother of the mother's father may have had immune deficiencies but two have grown to be teenagers with no problems. another died. at autopsy, however, lymph nodes appeared normal. the deceased older brother ... | 1977 | 401538 |
| the radiographic manifestations of chronic pneumocystis carinii pneumonia. | 1977 | 401576 | |
| serial propagation of pneumocystis carinii in cell line cultures. | pneumocystis carinii was propagated on three cell lines routinely cultured in many laboratories; the method is practical and convenient. organisms produced were found to be reactive to pneumocystis antisera. studies of antigenic relationships, life cycles, and diagnostic methods will be made easier by these cultures. | 1977 | 406845 |
| successful chemoprophylaxis for pneumocystis carinii pneumonitis. | in a randomized, double-blind, placebocontrolled study to evaluate the efficacy of trimethoprim-sulfamethoxazole for the prevention of pneumocystis carinii pneumonia, we studied 160 patients with cancer who were at high risk for this pneumonia over a two-year period. seventeen of the 80 patients receiving a placebo acquired p. carinii pneumonitis, whereas none of the 80 given 150 mg of trimethoprim and 750 mg of sulfamethoxazole per square meter per day had the infection p less than 0.01). bacte ... | 1977 | 412099 |
| infections in hairy-cell leukemia. | in order to determine the nature of infectious complications in hairy-cell leukemia we studied 20 consecutive patients seen at ucla and analyzed the available literature. the incidence of serious infection in our series was 40%, and pneumonia and septicemia due to pseudomonas and e. coli organisms were the leading types of infections. fungal infections with cryptococci and histoplasma organisms were documented, and a single case of pneumocystis carinii pneumonia was observed. noninfectious fever ... | 1978 | 416862 |
| [alveolointerstitial pneumopathy with pneumocystis carinii. incidence of the disease in a hospital department for premature and dystrophic infants]. | 1978 | 418481 | |
| diffuse pulmonary infiltrates in immunosuppressed patients. prospective study of 80 cases. | over a two year period, we studied prospectively 80 cases of diffuse pneumonia at memorial sloan-kettering cancer center. in 72 per cent of these, the patient had leukemia or lymphoma. diagnostic procedures consisted of extensive serologic testing for antibody to known respiratory pathogens, including the agent of legionnaire's disease, and culturing of biopsy specimens for bacteria, viruses, mycoplasmas and fungi. of 44 cases in which open lung biopsy was performed, a specific cause was found i ... | 1979 | 420237 |
| fiberoptic bronchoscopy in diagnosis of opportunistic lung infections: assessment of sputa, washings, brushings and biopsy specimens. | fiberoptic bronchoscopy (washings, brushings and biopsies) was done in 25 cases of proven opportunistic pulmonary infections in compromised hosts. diagnostic yields of bronchoscopic procedures and expectorated sputum were compared. sputum examination gave the lowest yield (14 percent). bronchial washings and brushings were diagnostic in 30 percent and 38 percent of patients, respectively. on transbronchial biopsy of the lung (tbb) pathogens were identified in 75 percent of patients with pneumocy ... | 1979 | 483790 |
| a new guinea pig mutant with abnormal hair production and immunodeficiency. | hairless guinea pigs were born in a closed colony of hartley guinea pigs. at birth, hairless guinea pigs were smaller than littermates, had wrinkled skin and stunted vibrissae. the most striking abnormality histologically was distension of the upper portion of the pilary canal with thickening of the epidermis. hairlessness resulted from production of abnormal hair shafts. preliminary work indicated that in addition to hairlessness, the guinea pigs were athymic or hypothymic. initial immunologic ... | 1979 | 529772 |
| [results of bronchial scrapings in interstitial pulmonary diseases in immunodeficient children (author's transl)]. | endobronchial scraping was used in 53 immunodeficient children, aged 4 months to 15 years, and divided into three categories (37 receiving immunosuppression treatment, 8 with marasmus, and 8 with immunodeficiency), in order to determine the etiology of their interstitial pneumopathy. the examination was made under blind conditions in 21 cases using an intubation tube (under assisted ventilation), and with bronchoscopy under general anesthesia in the other 32 cases. three scrapings were required ... | 1979 | 549512 |
| diagnostic fibreoptic bronchoscopy in the immunocompromised host with pulmonary infiltrates. | nineteen immunocompromised patients with pulmonary infiltrates underwent diagnostic fibreoptic bronchoscopy with transbronchial forceps and brush biopsy. a specific diagnosis was obtained in 21/25 procedures (10/11 focal lesions and 11/14 diffuse legions). the most common diagnosis was infection, and organisms isolated included bacteria, fungi, pneumocystis carinii, and herpes simplex. a pneumothroax requiring tube drainage occurred in two cases and mild lung parenchymal bleeding was noted in tw ... | 1977 | 594932 |
| [bronchial brushing in severe lung diseases in children]. | a distal bronchial brushing was performed in 25 children having severe lung diseases. the age of the patients ranged from 7 days to 14 years. seventeen children were immuno-depressed. bacteria were isolated five times (2 staphylococcus aureus, 1 streptococcus pneumoniae, 1 serratia marcenscens, 1 acinetobacter lwoffi), viruses twice (cytomegalovirus, syncytial respiratory virus), pneumocystis carinii, four times. cytologic study revealed malignant cells, and cells with intranuclear inclusions, e ... | 1978 | 637669 |
| [infections in children with cancer]. | in 38 patients with acute lymphocytic leukemia and hodgkin's disease 60 episodes of infection were registered showing the unquestionable increased susceptibility to infections in these cases. in 90% of the patients the infectious focus was localized and the pulmonary showed to be the most frequent. the etiology of the infection was established in 53% of the episodes and the bacterial, both gram-positive as gram-negative, showed the greatest frequency. in the second place came viral infections (m ... | 1978 | 687426 |
| the use of gallium-67 in pulmonary disorders. | imaging of the chest cage with gallium-67 (67ga) citrate is relatively easier to perform and interpret than imaging of the abdomen, because normally pulmonary concentration is low after 48 hr and physiologic accumulation in bones and breast can be recognized by its distribution. modern scintillation detectors, particularly large field cameras with multiple pulse-height analyzers, give substantially better gallium images than those available in the past. because of the nonspecific affinity of gal ... | 1978 | 715466 |
| [pneumocystis carinii infections following kidney transplantation]. | four adult recipients of cadaveric renal homografts acquired pneumocystis carinii infections from which they subsequently died. the disease in adults under immunosuppressive therapy runs a course different from the disease observed in newborns. the clinical course is rapidly progressive and early diagnosis by means of aggressive diagnostic procedures is mandatory. to prevent a fatal outcome, treatment even on suspicion is suggested. epidemiologically, a person-to-person spread seems possible and ... | 1975 | 766162 |
| infections in children with acute leukemia. | twenty children with all that died in 1959-1960 and 59 children with all that died in 1969-1970 were analyzed according to the infections at both their terminal illness and their initial presentations. despite the availability of more effective agents for pseudomonas and staphylococcus, the pattern of infecting organisms at the terminal illness did not change appreciably in this decade. e. coli, pseudomonas, staphylococcus, and candida were the principal organisms involved as a cause of death. t ... | 1975 | 778573 |
| lung complications during immunosuppressive treatment in renal transplant recipients. | pulmonary complications among 77 renal transplant recipients have been analysed. in the immediate postoperative period complications occurred with the same frequency as after other operations. later on, usually within 6 months, pneumonia caused by bacteria, pneumocystis carinii, cytomegalovirus and fungi occurred. the lung changes may indicate the underlying infecting organisms. mortality from pneumonia was 14% (11/77) including two patients with lung aspiration following emergency surgery. pulm ... | 1976 | 781834 |
| [diagnosis of pneumocystis carinii pneumonia by indirect immunofluorescence. technic, value of limitations of the method]. | the diagnosis of pneumocystis pneumonia can be established by indirect immunofluorescence test performed on the sera of the patients. this investigation has proved to be valid since it gives 50 p.cent of positive results in 16 confirmed cases. the false negative results can be imputed in some patients, to the extreme severity of the immune deficiency. | 1976 | 792806 |
| [unusual complication under immunosuppressive treatment: pneumocystis carinii pneumonia]. | 1976 | 793201 | |
| pneumocystis carinii as the cause of human disease: historical perspective and magnitude of the problem: introductory remarks. | the history of the discovery of pneumocystis carinii as the cause of interstitial plasma cell pneumonia of infants and of opportunistic infection with this parasite in the lungs of immuno-suppressed or severely debilitated adults and children is summarized with an extensive bibliography of the world literature through 1959. the problem of incriminating a nearly ubiquitous saprophyte as the cause of a disease and of elucidating the factors responsible for its causing pathogenesis in certain indiv ... | 1976 | 798122 |
| infections with pneumocystis carinii. | studies were reviewed on attempts to apply serologic methods for the laboratoary diagnosis of pneumocystis pneumonia and for epidemiologic surveillance in outbreaks of this disease. at autopsy the parasite was found in 7.7% of patients with a clinically latent infection. in this series of patients, parasitologic findings were not correlated with the results of a complement fixation (cf) test or with those of an indirect fluorescent antibody test. the high incidence of serologic reactivity in the ... | 1976 | 798123 |
| immunopathologic aspects of pneumocystis carinii pneumonia in infants as revealed by immunofluorescence and electron microscopy. | lung tissue, lymph nodes, and spleen from infants 4-15 weeks old who died of pneumocystis carinii pneumonia were studied by immunofluorescence and immunoelectron microscopy. the results strongly suggest that antibodies to p. carinii synthetized in lungs by inflammatory infiltrates and in regional lymph nodes are essential in the elimination of p. carinii from infected lungs through their opsonization of the p. carinii organisms. disintegration of p. carinii conglomerates subsequent to the bindin ... | 1976 | 798124 |
| pneumocystis carinii pneumonia in renal transplant recipients. | discussed are incidence, predisposing factors, presenting symptoms, diagnostic and isolation procedures, and therapy of pneumocystis carinii pneumonia in renal transplant recipients. a case is reported of a 46-year-old recipient of a cadaveric kidney, who develop p. carinii infection and was successfully treated with pentamidine isethionate. | 1976 | 798125 |
| fatal infections in protein-calorie malnourished children with thymolymphatic atrophy. | the clinicopathological features of 25 children who died with protein-calorie malnutrition were studied. all but four subjects were found at necropsy to have nutritional thymectomy and all but 3 died of infectious diseases. the infectious agents were chiefly intracellular micro-organisms including miliary tuberculosis, herpes simplex, varicella, measles, pneumocystis carinii, and plasmodium falciparum. staphylococcal infections, salmonellosis, shigellosis, strongyloidiasis, and hookworm were oth ... | 1975 | 805568 |
| [pneumonia as a cause of death in children (author's transl)]. | the yearly death-rate from pneumonia in children aged one month to 15 years has fallen in schleswig-holstein from 1.8 (1954-1958) to 0.6 per ten thousand (1969-1973). at the same time, total death-rate in the same age group has fallen from 14.5 to 9.3 per ten thousand children. the proportion of pneumonia in the total death-rate was 5.3% in 1971-1973, 1.6% in the first month of life and, after the sixteenth year, 2.3%. pneumonia was in fourth place (after accident, malformation and neoplasm) as ... | 1975 | 805694 |
| pneumocystis carinii infection in splenectomized owl monkeys. | interstitial pneumonia due to pneumocystis carinii was diagnosed in 2 splenectomized owl monkeys. pneumonia was considered an important lesion in 1 monkey, but only an incidental finding in the 2nd monkey. nephritis was considered to be the primary lesion in both monkeys. | 1975 | 809395 |
| pulmonary pneumocystosis in nonhuman primates. | pulmonary infection with pneumocystis carinii was detected in two aged owl monkeys (aotus trivirgatus) and two young chimpanzees (pan troglodytes). the clinical histories of the owl monkeys were similar and included progressive weight loss, anorexia, failure to thrive, and death. one of the owl monkeys had no concurrent disease, whereas the other had been experimentally inoculated with treponema pallidum 44 months before death. in both chimpanzees, an underlying myeloproliferative malignant neop ... | 1976 | 814879 |
| [pneumocystis carinii pneumonia in infants]. | 1976 | 821124 | |
| [alveolo-interstitial pneumocystis carinii pneumonia]. | 1976 | 821125 | |
| therapy and prophylaxis of pneumocystis carinii pneumonia. | pentamidine isethionate and sulfadoxine plus pyrimethamine are excellent therapeutic agents in experimental and hypoergic, hypoimmune pneumocystosis as well as in focal interstitial plasma cell pneumonia (ipcp) in infants. their effectiveness is seriously limited in cases in which either a diffuse massive plasma cell exudate has been established or in adults in whom the phagocytic and resorptive facility is depressed. infantile pneumocystosis leading to ipcp can be completely prevented by proper ... | 1976 | 828241 |
| evaluation of transbronchial biopsy of the lung. | transbronchial biopsy of the lung through the fiberoptic bronchoscope is becoming a widely utilized clinical diagnostic technic. the authors reviewed the histologic features of 109 consecutive cases. the primary problem is the small size of the pulmonary tissue samples obtained, which is further compounded by an apparent mechanical inability to enter the biopsy forceps into dense nodules of neoplastic tissue. the diagnosis of carcinoma can best be made by examining the periphery of the cancer fo ... | 1977 | 868801 |
| diagnostic lavage and occult pulmonary hemorrhage in thrombocytopenic immunocompromised patients. | twenty consecutive thrombocytopenic immunocompromised patients with pulmonary infiltrates underwent diagnostic bronchopulmonary lavage. nine patients were found to have occult pulmonary hemorrhage as evidenced by increased stainable hemosiderin within alveolar macrophages. other diagnoses established included pneumocystis carinii pneumonia in 2 patients and metastatic carcinoma in 1. no hemorrhage was precipitated by the procedure, even in 7 patients whose platelet counts were less than or equal ... | 1977 | 889174 |
| [severe combined immunodeficiency with hypergamma-e eosinophilia, icthyosis and normal serum adenosin-deaminase (author's transl)]. | a two months old girl whose parents and grand-parents were consanguineous, and a former brother died when eight months old with a similar clinical picture is studied. our patient developed diarrhea at the age of fifteen days, and icthyosiform skin lesions when she was one month old. enlarged lymph nodes were prominent. she died with severe lung and ear infection. no evidence of skeletal abnormalities were found. eosinophil count was high (720-1,000/mm3), ige was increased for age (760 u.u./ml.), ... | 1977 | 907236 |
| in vitro inhibition of platelet function and coagulation by pentamidine isethionate. | pentamidine isethionate is a trypanocidal drug used for the treatment of pneumocystis carinii pneumonitis. hematological complications have occasionally been reported and include anemia, leukopenia, and thrombocytopenia. we report here several qualitative abnormalities of in vitro platelet function and coagulation that have not been described previously. platelets were exposed in vitro to concentrations of pentamidine isethionate ranging from 0.5 to 100 mug/ml of platelet-rich plasma. clot retra ... | 1977 | 921238 |
| neurologic involvement in seven patients with behçet's disease. | of 25 patients with behçet's disease seen in five years at the mayo clinic, seven had central nervous system involvement. the mean interval from onset of behçet's disease to central nervous system involvement was 1.3 years, and the mean period of observation thereafter was 3.8 years. all patients had headache and fever during or preceding exacerbations of the central nervous system disease, and all had cerebrospinal fluid pleocytosis (white cell counts ranged from 6 to 490/mm3) with predominant ... | 1976 | 952291 |
| combination chemotherapy with adramycin (nsc-123127) and dimethyl triazeno imidazole carboxamide (dtic) (nsc-45388) in children with metastatic sold tumors. | combination chemotherapy with adriamycin and dtic was used in 102 evaluable patients under 15 years of age who had previously treatted metastatic solid tumors. responses, defined as 50% or more reduction in all tumor masses, occured in 10 out of 27 patients with neuroblastoma, 3 out of 8 patients with wilms tumor, 7 out 15 patients with ewing sarcoma, 2 out of 6 patients with osteosarcoma, 5 out of 13 patients with rhabdomyosarcoma, and 15 out of 33 patients with miscellaneous tumors which incl ... | 1976 | 958160 |
| pharmacologic aspects of pentamidine. | pentamidine is an aromatic diamidino compound synthesized originally for the therapy of trypanosomiasis. the pharmacologic effects of pentamidine vary, depending on its route of administration. in animals, the dominant effects have been a precipitous, transitory drop in blood pressure after injection and renal toxicity following repeated administration. to avoid the possibility of immediate toxic reactions associated with iv administration, we now usually give the drug im to humans. further inte ... | 1976 | 1018718 |
| bilateral interstitial pneumonia in acute lymphoblastic leukemia. | of 148 children with acute lymphoblastic leukemia (all) 34 had bilateral interstitial pneumonia (bip). their records were reviewed retrospectively to evaluate the incidence of this pneumonia and delineate the various etiologic factors involved. all but 1 were in remission; 82% of the episodes occurred within the first 6 months, the majority of these occurring during the first 3 months of diagnosis of all; 16 were receiving methotrexate (mtx), and 14 were receiving combination chemotherapy with v ... | 1976 | 1069476 |
| letter: pneumocystis carinii pneumonia. | 1975 | 1079057 | |
| failure of pentamidine isethionate to provide chemoprophylaxis against pneumocytis carinii infection in rats. | latent pneumocystis carinii infections were exacerbated in 54 adult male sprague-dawley rats by administration of alternating subcutaneous doses of hydrocortisone-21-phosphate and of cortisone acetate three times a week, plus 0.5% chlortetracycline in their drinking water, until death or the termination of the experiment at 120 days. twenty-eight of the rats were also given pentamidine isethionate (4mg/kg) intramuscularly daily for 14 days. pentamidine-treated animals that died within the 120 da ... | 1975 | 1079218 |
| the effect of dimethyl sulfoxide on pneumocystis carinii. | 1975 | 1079424 | |
| treatment of pneumocystis carinii pneumonitis with trimethoprim-sulfamethoxazole. | pneumocystis carinii pneumonitis (pcp) is fatal in 90 to 100% of the cases if no treatment is given. trimethoprim-sulfamethoxazole (tmp-smx) was used at one of two dosage levels in the treatment of 20 children with pcp and cancer. of 14 patients treated with 20 mg tmp--100 mg smx/kgd, 12 recovered and 2 died. treatment of the fatal cases and one of the patients who recovered was supplemented with pentamidine. when six patients were treated with 4 to 7 mg tmp--20 to 35 mg smx/kgd, four recovered ... | 1975 | 1079469 |
| pneumocystis carinii pneumonia. diagnosis by lung biopsy. | pneumocystis carinii pneumonia was suspected in 52 patients who underwent lung biopsy for diagnosis of diffuse pulmonary infiltrates. all but five of the procedures were limited thoracotomies. there were no instances of significant postoperative hemorrage or of pneumothorax compromising ventilation. the diagnosis of p. carinii pneumonia was made rapidly from imprints of the lung stained by the gram-weigert method in the 18 patients who had p. carinii pneumonia. over-all, the rate of recovery fro ... | 1975 | 1079692 |
| pneumocystis carinii infections in zoo animals. | pneumocystis carinii was found to be present in the lungs of twenty-three zoo animals in the netherlands. the following species were represented: red kangaroo, common tree shrew, senegal-galago, demidoff's-galago, brown howler monkey, woolly monkey, long-haired spider monkey, white-eared marmoset, chimpanzee, three-toed sloth, palm squirrel, red panda, fennec fox, tree hyrax and large-toothed hyrax. | 1975 | 1079994 |
| continuous negative chest-wall pressure as therapy for severe respiratory distress in older children. | continuous negative chest-wall pressure (cnp) was used to treat five children, 4 to 11 years of age, who had progressively severe respiratory distress caused by pneumocystis carinii penumonitis. after initial improvement, two patients developed progressive increases in respiratory rate, alveolar-arterial oxygen gradient, intrapulmonary right-to-left shunt, and hypoxia. the disease ended fatally in both. the remaining three patients continued to improve and recovered from their pulmonary disease. ... | 1975 | 1080095 |
| pneumocystis carinii infestation. | 1975 | 1080481 | |
| transbronchial lung biopsy via the fiberoptic bronchoscope. experience with 107 consecutive cases and comparison with bronchial brushing. | transbronchial lung biopsy (tbb) was performed during fiberoptic bronchoscopy under fluoroscopic guidance in 107 patients. tbb was diagnostic in 17 of 21 (81 percent) cases with localized malignant lesions greater than 4 cm in diameter and bronchial brushing was positive in 12 (57 percent). tbb was diagnostic in 14 of 24 (58 percent) cases with localized malignant lesions equal to or less than 4 cm in diameter, whereas brush biopsy was positive in 7 (29 percent). in 13 cases with suspected pneum ... | 1975 | 1080700 |
| letter: smooth muscle antibody in children with pneumocystis carinii pneumonia. | 1975 | 1081135 | |
| letter: pneumocystis carinii in a vietnamese foundling. | 1975 | 1081338 | |
| intensity of immunosuppressive therapy and the incidence of pneumocystis carinii pneumonitis. | one hundred and forty-nine children with acute lymphocytic leukemia treated according to a prospective protocol were randomized after induction of remission and central nervous system (cns) irradiation to receive maintenance chemotherapy with 1, 2, 3, or 4 chemotherapy agents. the incidence of p. carinii pneumonitis (pcp) was 5.0, 2.3, 2.2, and 22.4%, respectively, during the period of maintenance therapy. an additional 31 patients enrolled in the same study were placed in special categories to ... | 1975 | 1081905 |
| [2 cases of pneumocystis carinii pneumonia. case 1: diffuse interstitial pneumonia observed in a case simulating dermatomyositis. case 2: diffuse interstitial pneumonia in acute myelocytic leukemia]. | 1975 | 1082043 | |
| atypical radiographic features in pneumocystis carinii pneumonia. | the chest films in 30 proved cases of pneumocystis carinii pneumonia were reviewed to determine the incidence of atypical radiographic findings. seventeen of 30 patients or 56% presented at least one atypical radiographic finding during the course of the disease. unilateral distribution, lobar involvement, abscess formation, fulminant progression, and atelectatic changes were observed in more than half the patients. a classic radiographic presentation, justifying treatment without biopsy, was se ... | 1975 | 1082150 |
| [fever, edema, eosinophilia and acute pneumonia: bilateral, diffuse pneumocystis carinii pneumonia and candida pneumonia of the left lung (evaluation of eosinophilia)]. | 1975 | 1082519 | |
| [interstitial pneumonia in children on cystostatic treatment for malignant systematic disease (author's transl)]. | the radiologic appearances of interstitial pneumonia are described as they appeared in 39 children treated with immunosuppressive and cytostatic substances given for malignant systemic disease. at the time most of the children were in a stage of remission of their basic illness. in most of them there may have been a pneumocystis carinii infection. 15 children died of this pneumonia. in the majority of post-mortem examinations pneumocysts could be detected. | 1975 | 1082626 |
| [autoantibodies in children with pneumocystis carinii pneumonia]. | 1976 | 1083006 | |
| [radiological evaluation of the course of pneumocystosis (author's transl)]. | serial chest x rays were performed on 124 infants in an orphanage with endemic pneumocystic carinii infection. the infection was serologically and autoptically proven in 98 cases. the interstitial infiltrate in the lungs is not specific for pneumocystis carinii infection, but is the result of the host reaction, which persists after the antigen has been destroyed. the interstitial infiltrate is therefore neither time-related nor diagnostic and cannot be used as a guideline for therapy. the treatm ... | 1976 | 1083036 |
| pneumocystis pneumonia: the importance of early open lung biopsy. | pulmonary infection due to pneumocystis carinii is now recognized as the leading cause of death from infection in patients with a hematologic malignancy who are in remission. effective treatment requires suspicion of the infection in susceptible patients and rapid identification of the organism. in most patients, open lung biopsy performed through a small anterior thoracotomy provides immediate identification or exclusion of the organism, thus allowing treatment of infected patients and avoidanc ... | 1976 | 1083218 |
| latent pneumocystis carinii infections in some mammals from taipei hsien, taiwan. | 1975 | 1083423 | |
| abnormal pulmonary gallium accumulation in p. carinii pneumonia. | the potentially fatal interstitial pneumonia of pneumocystis carinii is a frequent opportunistic invader of patients treated for malignancy with immunosuppressive and cytotoxic agents. generalized ga-67 pulmonary localization which is markedly disproportionate to the clinical and radiographic findings has led to earlier diagnoses by open lung biopsy in this setting. the potential usefulness of gallium scintigraphy in patients with suspected p. carini pneumonia is presented. | 1976 | 1083546 |
| [pneumocystis carinii pneumonia in infants at the children's hospital in warsaw]. | 1976 | 1083982 | |
| [progress in the diagnosis and treatment of pneumocystis carinii pneumonia]. | 1976 | 1084066 | |
| infection due to pneumocystis carinii simulating lobar bacterial pneumonia. | 1976 | 1084255 | |
| pneumocystis carinii pneumonia in two vietnamese refugee infants. | 1976 | 1084514 | |
| pneumocystis and histoplasma infections in wild animals from the amazon region of brazil. | routine examination of tissues from wild forest rodents from amapá, north brazil, revealed pneumocystis carinii in lung smears from a newly captured oryzomys capito (cricetidae). acute, fatal infections with this parasite are also recorded in a number of captive "coatimundis", nasua narica (carnivora: procyonidae) and a sloth, bradypus tridactylus (edentata). pneumocystis was also encountered in lung smears from a newly captured and apparently healthy sloth, choloepus didactylus. the presence of ... | 1975 | 1084602 |
| [current aspects of differentiation and treatment of pneumocystis carinii pneumonia (author's transl)]. | there are two types of pneumocystis carinii pneumonia. one is seen in premature and atrophic infants mainly during the 2nd to 6th month, with massive interstitial proliferation of plasmacells and acute respiratory crisis. the second typ is observed in immunodeficient children and adults with only little or no plasmacell infiltration due to the hypoimmune, hypoergic state. pentamidine is the drug of choice in the therapy of pneumocystis carinii pneumonia; in serious cases it will be combined with ... | 1976 | 1084954 |
| [interstitial pneumopathies in children treated for malignant diseases]. | the authors report 21 cases of severe interstitial pneumonitis observed in 1974 in paris, in children with malignancies, either solid tumours or leukemias. twelve patients died. the incidence of these complications in children with intensive chemotherapy and the clinical symptoms which may reveal them are reviewed; the bad prognosis of measles in these patients is stressed. radiological findings are described and the possible wrong diagnoses are listed. among viral infections, measles is the sev ... | 1976 | 1085139 |