Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| arctium lappa ameliorates endothelial dysfunction in rats fed with high fat/cholesterol diets. | arctium lappa l. (asteraceae), burdock, is a medicinal plant that is popularly used for treating hypertension, gout, hepatitis, and other inflammatory disorders. this study was performed to test the effect of ethanol extract of arctium lappa l. (eal) seeds on vascular reactivity and inflammatory factors in rats fed a high fat/cholesterol diet (hfcd). | 2012 | 22866890 |
| ethanolic extract of roots from arctium lappa l. accelerates the healing of acetic acid-induced gastric ulcer in rats: involvement of the antioxidant system. | we evaluate the curative efficacy of the ethanolic extract (eet) of roots from arctium lappa (bardana) in healing of chronic gastric ulcers induced by 80% acetic acid in rats and additionally studies the possible mechanisms underlying this action. oral administration of eet (1, 3, 10 and 30mg/kg) reduced the gastric lesion area in 29.2%, 41.4%, 59.3% and 38.5%, respectively, and at 10mg/kg promoted significant regeneration of the gastric mucosa, which was confirmed by proliferating cell nuclear ... | 2013 | 23036453 |
| effect of arctiin on glomerular filtration barrier damage in stz-induced diabetic nephropathy rats. | diabetic nephropathy (dn) is the major life-threatening complication of diabetes. abnormal permeability of glomerular basement membrane plays an important role in dn pathogenesis. this study was performed to assess the effect of arctiin, the lignan constituent from arctium lappa l., on metabolic profile and aggravation of renal lesions in a rat model of streptozotocin (stz)-induced dn. stz-induced diabetic rats were treated with arctiin at the dosage of 60 or 40 mg/kg/day via intraperitoneal inj ... | 2013 | 23147865 |
| uplc and hplc of caffeoyl esters in wild and cultivated arctium lappa l. | analytical methods including ultra-performance liquid chromatography (uplc) and high-performance liquid chromatography (hplc) with photodiode array (pda) detector were developed for the analysis of caffeoylquinic acid derivatives in seeds, leaves and roots of arctium lappa l. separation was performed on c(18) column utilising 5% (v/v) acetic acid in water and acetonitrile at 330 nm. both methodologies were validated in terms of linearity, precision, and recovery. the results showed that the majo ... | 2013 | 23265494 |
| anti-inflammatory intestinal activity of arctium lappa l. (asteraceae) in tnbs colitis model. | in brazilian traditional medicine, arctium lappa (asteraceae), has been reported to relieve gastrointestinal symptoms. | 2013 | 23313393 |
| arctigenin ameliorates inflammation in vitro and in vivo by inhibiting the pi3k/akt pathway and polarizing m1 macrophages to m2-like macrophages. | seeds of arctium lappa, containing arctigenin and its glycoside arctiin as main constituents, have been used as a diuretic, anti-inflammatory and detoxifying agent in chinese traditional medicine. in our preliminary study, arctigenin inhibited ikkβ and nf-κb activation in peptidoglycan (pgn)- or lipopolysaccharide (lps)-induced peritoneal macrophages. to understand the anti-inflammatory effect of arctigenin, we investigated its anti-inflammatory effect in lps-stimulated peritoneal macrophages an ... | 2013 | 23375938 |
| hydrolysis is the dominating in vivo metabolism pathway for arctigenin: identification of novel metabolites of arctigenin by lc/ms/ms after oral administration in rats. | the phenylpropanoid dibenzylbutyrolactone lignan arctigenin, a key component found in arctium lappa, or burdock, has been reported with a variety of therapeutic effects including anticancer, anti-inflammation, and antivirus effects. using lc/ms/ms, three novel metabolites of arctigenin, namely, arctigenic acid, arctigenin-4-o'-glucuronide, and 4-o-demethylarctigenin were identified after oral administration of arctigenin in rats for the first time. another potential metabolite of arctigenin, arc ... | 2013 | 23519790 |
| anti-austeric activity of phenolic constituents of seeds of arctium lappa. | from seeds of arctium lappa l. (asteraceae) we obtained arctigenin (1), arctiin (2), chlorogenic acid (3), 4,5-dicaffeoylquinic acid (4), 3,5-dicaffeoylquinic acid (5), 3,4-dicaffeoylquinic acid (6), matairesinol (11), isolappaol a (12), lappaol f (14), and lappaol b (15), together with 1:1 mixtures of isolappaol c (7) and lappaol c (8), arctignan e (9) and arctignan d (10), and 12 and lappaol a (13), while 3,3',4'-tri-o-demethylarctigenin (16), 3,3'-di-o-demethyl-4'-dehydroxyarctigenin (17), an ... | 2013 | 23738454 |
| antioxidative/acetylcholinesterase inhibitory activity of some asteraceae plants. | the extracts obtained by 80% etoh from some asteraceae plants (calendula officinalis, inula helenium, arctium lappa, artemisia absinthium and achillea millefolium) were studied. rosmarinic acid, one of the main compounds identified in all extracts, was determined quantitatively by using hplc. in addition, spectrophotometric methods were evaluated as an alternative for rosmarinic acid content determination. total phenolic content was also established for all extracts. a. millefolium extract was f ... | 2013 | 23738456 |
| determination of fructooligosaccharides in burdock using hplc and microwave-assisted extraction. | the root of burdock ( arctium lappa l.) is a commonly used vegetable in asia. fructooligosaccharides (fos) are usually considered as its main bioactive components. thus, quantitative analysis of these components is very important for the quality control of burdock. in this study, an hplc-elsd and microwave-assisted extraction method was developed for the simultaneous determination of seven fos with degrees of polymerization (dp) between 3 and 9, as well as fructose, glucose, and sucrose in burdo ... | 2013 | 23745967 |
| inhibitory effect of arctigenin from fructus arctii extract on melanin synthesis via repression of tyrosinase expression. | to identify the active compound arctigenin in fructus arctii (dried seed of medicinal plant arctium lappa) and to elucidate the inhibitory mechanism in melanogenesis, we analyzed melanin content and tyrosinase activity on b16bl6 murine melanoma and melan-a cell cultures. water extracts of fructus arctii were shown to inhibit tyrosinase activity in vitro and melanin content in α -melanocyte stimulating hormone-stimulated cells to similar levels as the well-known kojic acid and arbutin, respective ... | 2013 | 23781272 |
| update on phase i studies in advanced pancreatic adenocarcinoma. hunting in darkness? | over the last twenty years, there is a limited number of effective cytotoxic or biological agents that managed to get approval in advanced pancreatic ductal adenocarcinoma. despite numerous trials, investments in translational research and generally in health care, the survival of pancreatic cancer patients has improved by a few only months. this disappointing reality necessitates a better understanding of the pathogenesis of this disease and the identification of targetable alterations which mi ... | 2013 | 23846926 |
| burdock fructooligosaccharide induces stomatal closure in pisum sativum. | burdock fructooligosaccharide (bfo) isolated from the root tissue of arctium lappa is a reserve carbohydrate that can induce resistance against a number of plant diseases. stomatal closure is a part of plant innate immune response to restrict bacterial invasion. in this study, the effects of bfo on stomata movement in pisum sativum and the possible mechanisms were studied with abscisic acid (aba) as a positive control. the results showed that bfo could induce stomatal closure accompanied by ros ... | 2013 | 23911508 |
| characterization of burdock mottle virus, a novel member of the genus benyvirus, and the identification of benyvirus-related sequences in the plant and insect genomes. | the complete nucleotide sequence of the burdock mottle virus (bdmov) isolated from an edible burdock plant (arctium lappa) in japan has been determined. bdmov has a bipartite genome, whose organization is similar to rna1 and rna2 of benyviruses, beet necrotic yellow vein virus (bnyvv), beet soil-borne mosaic virus (bsbmv), and rice stripe necrosis virus (rsnv). bdmov rna1 (7038 nt) contains a single open reading frame (orf) encoding a 249-kda polypeptide that consists of methyl-transferase, heli ... | 2013 | 23911632 |
| arctigenin effectively ameliorates memory impairment in alzheimer's disease model mice targeting both β-amyloid production and clearance. | alzheimer's disease (ad) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. the β-amyloid (aβ)-induced neurodegeneration is believed to be the main pathological mechanism of ad, and aβ production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-ad research. here, we report that the natural product arctigenin from arctium lappa (l.) can both inhibit aβ prod ... | 2013 | 23926267 |
| preparation of inulin-type fructooligosaccharides using fast protein liquid chromatography coupled with refractive index detection. | a fast protein liquid chromatography coupled with refractive index detection (fplc-rid) method was firstly developed for preparation and purification of fructooligosaccharides with different degree of polymerization from burdock, arctium lappa. after extraction with 60% ethanol and decolorization with mci gel chp20p, total fructooligosaccharides were purified on bio-gel p-2 column eluted with water at the flow rate of 0.3 ml/min, which was the optimized conditions. the obtained fructooligosaccha ... | 2013 | 23962565 |
| mechanism of arctigenin-mediated specific cytotoxicity against human lung adenocarcinoma cell lines. | the lignan arctigenin (arg) from the herb arctium lappa l. possesses anti-cancer activity, however the mechanism of action of arg has been found to vary among tissues and types of cancer cells. the current study aims to gain insight into the arg mediated mechanism of action involved in inhibiting proliferation and inducing apoptosis in lung adenocarcinoma cells. this study also delineates the cancer cell specificity of arg by comparison with its effects on various normal cell lines. arg selectiv ... | 2013 | 24021157 |
| arctigenin exhibits relaxation effect on bronchus by affecting transmembrane flow of calcium. | arctigenin, a lignan extract from arctium lappa (l.), exhibits anti-inflammation, antioxidation, vasodilator effects, etc. however, the effects of arctigenin on bronchus relaxation are not well investigated. this study aimed to investigate how arctigenin regulates bronchus tone and calcium ion (ca(2+)) flow. trachea strips of guinea pigs were prepared for testing the relaxation effect of arctigenin to acetylcholine, histamine, kcl, and cacl2, respectively. furthermore, l-type calcium channel cur ... | 2013 | 24114345 |
| arctigenin promotes cholesterol efflux from thp-1 macrophages through ppar-γ/lxr-α signaling pathway. | cholesterol efflux from macrophages is a critical mechanism to prevent the development of atherosclerosis. here, we sought to investigate the effects of arctigenin, a bioactive component of arctium lappa, on the cholesterol efflux in oxidized low-density lipoprotein (oxldl)-loaded thp-1 macrophages. our data showed that arctigenin significantly accelerated apolipoprotein a-i- and high-density lipoprotein-induced cholesterol efflux in both dose- and time-dependent manners. moreover, arctigenin tr ... | 2013 | 24140409 |
| arctigenin, a dietary phytoestrogen, induces apoptosis of estrogen receptor-negative breast cancer cells through the ros/p38 mapk pathway and epigenetic regulation. | this study investigates the anticancer effect of arctigenin (atg), a natural lignan product of arctium lappa l., in human breast cancer mda-mb-231 cells. results indicate that atg inhibits mda-mb-231 cell growth by inducing apoptosis in vitro and in vivo. atg triggers the mitochondrial caspase-independent pathways, as indicated by changes in bax/bcl-2 ratio, resulting in aif and endog nuclear translocation. atg increased cellular reactive oxygen species (ros) production by increasing p22(phox)/n ... | 2014 | 24140706 |
| effect of arctium lappa (burdock) extract on canine dermal fibroblasts. | although the biological activities of arctium lappa (burdock) have been already investigated in human and other species, data evaluating the molecular mechanisms have not been reported in the dog. in this study we analyzed for the first time the effect of a root extract of burdock on molecular responses in canine dermal fibroblasts with h2o2 stimulation (h group), with burdock treatment (b group) and with h2o2 stimulation and burdock treatment (bh group), using rnaseq technology. differentially ... | 2013 | 24192279 |
| lappaol f, a novel anticancer agent isolated from plant arctium lappa l. | in an effort to search for new cancer-fighting therapeutics, we identified a novel anticancer constituent, lappaol f, from plant arctium lappa l. lappaol f suppressed cancer cell growth in a time- and dose-dependent manner in human cancer cell lines of various tissue types. we found that lappaol f induced g(1) and g(2) cell-cycle arrest, which was associated with strong induction of p21 and p27 and reduction of cyclin b1 and cyclin-dependent kinase 1 (cdk1). depletion of p21 via genetic knockout ... | 2014 | 24222662 |
| study on human intestinal bacterium blautia sp. auh-jld56 for the conversion of arctigenin to (-)-3'-desmethylarctigenin. | arctium lappa l. (a. lappa) is a popularly used vegetable as well as herbal medicine. human intestinal microflora was reported to convert arctiin, the lignan compound with highest content in the dried fruits of arctium lappa, to a series of metabolites. however, the specific bacterium responsible for the formation of 3'-desmethylarctigenin (3'-dmag), the most predominant metabolite of arctiin by rat or human intestinal microflora, has not been isolated yet. in the present study, we isolated one ... | 2013 | 24236649 |
| evaluation of hypoglycemic activity of total lignans from fructus arctii in the spontaneously diabetic goto-kakizaki rats. | fructus arctii, called "niubangzi" in china (great burdock achene in english), is a well-known chinese materia medica. it is the dried ripe fruit of arctium lappa l. (family asteraceae) and was included in the chinese pharmacopoeia for its traditional therapeutic actions. meanwhile it has been utilized extensively in a number of classical drug formulas as a major component for the treatment of noninsulin-dependent diabetes mellitus. it has also been reported recently that the clinical use of fru ... | 2014 | 24269245 |
| the efficacy and safety of a proposed herbal moisturising cream for dry skin and itch relief: a randomised, double-blind, placebo-controlled trial--study protocol. | moisturisers prevent and treat dry skin. they can also protect sensitive skin, improve skin tone and texture, and mask imperfections. herbal medicines or their extracts have been available as topical formulations and cosmetics. arctium lappa l. (asteraceae) has been used to treat inflammatory disorders and various skin problems. it could be a candidate herbal medicine for treating dry skin condition.this study aims to establish the efficacy and safety of a proposed herbal moisturising cream cont ... | 2013 | 24274317 |
| arctiin induces an uvb protective effect in human dermal fibroblast cells through microrna expression changes. | ultraviolet (uv) radiation induces severe alterations in the molecular and cellular components of normal human dermal fibroblast (nhdf) cells by disrupting many intracellular transduction cascades. although uv responses have been well documented at the genome and proteome levels, uv protective effects have not been elucidated at these levels. the aim of the present study was to demonstrate that arctiin, a phytochemical isolated from the plant arctium lappa, induced a protective effect against uv ... | 2014 | 24398562 |
| arctigenin inhibits osteoclast differentiation and function by suppressing both calcineurin-dependent and osteoblastic cell-dependent nfatc1 pathways. | arctigenin, a lignan-derived compound, is a constituent of the seeds of arctium lappa. arctigenin was previously shown to inhibit osteoclastogenesis; however, this inhibitory mechanism has yet to be elucidated. here, we showed that arctigenin inhibited the action of nuclear factor of activated t-cells, cytoplasmic 1 (nfatc1), a key transcription factor for osteoclastogenesis. nfatc1 in osteoclast precursors was activated through two distinct pathways: the calcineurin-dependent and osteoblastic c ... | 2014 | 24465763 |
| in vitro and in vivo antioxidant activity of a fructan from the roots of arctium lappa l. | to explore new antioxidant resource from food, a water-soluble polysaccharide (alp1) was extracted and purified from the roots of arctium lappa l. (a. lappa l.) through hot water extraction followed by ethanol precipitation, ion-exchange chromatography and gel filtration. the antioxidant activity of alp1 was then evaluated in vitro and in vivo. alp1 was characterized as a fructan composed of fructose and glucose in the ratio of 13.0:1.0, with an average molecular weight of 4600 da. the linkages ... | 2014 | 24508920 |
| contact dermatitis as an adverse reaction to some topically used european herbal medicinal products - part 1: achillea millefolium-curcuma longa. | this review focuses on contact dermatitis as an adverse effect of a selection of topically used herbal medicinal products for which the european medicines agency has completed an evaluation up to the end of november 2013 and for which a community herbal monograph has been produced. part 1: achillea millefolium l.-curcuma longa l. | 2014 | 24621152 |
| arctigenin promotes apoptosis in ovarian cancer cells via the inos/no/stat3/survivin signalling. | arctigenin is a biologically active lignan extracted from the seeds of arctium lappa and shows anticancer activity against a variety of human cancers. the aim of this study was to determine the effects of arctigenin on ovarian cancer cell proliferation and survival and associated molecular mechanisms. human ovarian cancer ovcar3 and skov3 cells were treated with arctigenin, and cell proliferation and apoptosis were assessed. western blot analysis was used to examine signal transducer and activat ... | 2014 | 24842412 |
| control of microorganisms of oral health interest with arctium lappa l. (burdock) extract non-cytotoxic to cell culture of macrophages (raw 264.7). | to evaluate the antimicrobial activity of arctium lappa l. extract on staphylococcus aureus, s. epidermidis, streptococcus mutans, candida albicans, c. tropicalis and c. glabrata. in addition, the cytotoxicity of this extract was analyzed on macrophages (raw 264.7). | 2014 | 24863657 |
| hepatoprotective effect of arctium lappa root extract on cadmium toxicity in adult wistar rats. | this study was performed to determine the effects of arctium lappa (al) to protect against cadmium damage in the rat liver. male rats received a single i.p. dose of cdcl2 (1.2 mg/kg body weight (bw)) with or without al extract administered daily by gavage (300 mg/kg bw) for 7 or 56 days. after 7 days, al caused plasma transaminase activity to diminish in groups al (glutamic oxaloacetic transaminase (got) and glutamic pyruvic transaminase (gpt)) and cdal (gpt). after 56 days, got and gpt plasma a ... | 2014 | 24929543 |
| observational study of arctium lappa in the treatment of acne vulgaris. | arctium lappa (lappa) is used in traditional western and chinese medicine for acne. it is mentioned in homeopathic literature for acne, but its effect has not previously been evaluated. | 2014 | 24931753 |
| chemical analysis and antihyperglycemic activity of an original extract from burdock root (arctium lappa). | in the present study, we obtained a dried burdock root extract (dbre) rich in caffeoylquinic acids derivatives. we performed the chemical characterization of dbre and explored its antihyperglycemic potential in both in vitro and in vivo experiments. chemical analysis of dbre using lc-ms and gc-ms revealed the presence of a great majority of dicaffeoylquinic acid derivatives (75.4%) of which 1,5-di-o-caffeoyl-4-o-maloylquinic acid represents 44% of the extract. in the in vitro experiments, dbre i ... | 2014 | 24933284 |
| antitubercular activity of arctium lappa and tussilago farfara extracts and constituents. | arctium lappa and tussilago farfara (asteraceae) are two plant species used traditionally as antitubercular remedies. the aim of this study was (i) to screen arctium lappa and tussilago farfara extracts for activity against mycobacterium tuberculosis and (ii) to isolate and identify the compound(s) responsible for this reputed anti-tb effect. | 2014 | 24955560 |
| neuroprotective effects of arctium lappa l. roots against glutamate-induced oxidative stress by inhibiting phosphorylation of p38, jnk and erk 1/2 mapks in pc12 cells. | many studies have shown that glutamate-induced oxidative stress can lead to neuronal cell death involved in the development of neurodegenerative diseases. in this work, protective effects of ethyl acetate extract (eae) of arctium lappa l. roots against glutamate-induced oxidative stress in pc12 cells were evaluated. also, the effects of eae on antioxidant system, mitochondrial pathway, and signal transduction pathway were explored. pretreatment with eae significantly increased cell viability, ac ... | 2014 | 24956398 |
| body weight management effect of burdock (arctium lappa l.) root is associated with the activation of amp-activated protein kinase in human hepg2 cells. | burdock (arcticum lappa l.) root is used in folk medicine and also as a vegetable in asian countries. in the present study, burdock root treatment significantly reduced body weight in rats. to evaluate the bioactive compounds, we successively extracted the burdock root with ethanol (al-1), and fractionated it with n-hexane (al-2), ethyl acetate (al-3), n-butanol (al-4), and water (al-5). among these fractions, al-2 contained components with the most effective hypolipidemic potential in human hep ... | 2012 | 25005949 |
| effect of plant extracts on h2o2-induced inflammatory gene expression in macrophages. | arctium lappa (al), camellia sinensis (cs), echinacea angustifolia, eleutherococcus senticosus, panax ginseng (pg), and vaccinium myrtillus (vm) are plants traditionally used in many herbal formulations for the treatment of various conditions. although they are well known and already studied for their anti-inflammatory properties, their effects on h2o2-stimulated macrophages are a novel area of study. | 2014 | 25075197 |
| hepatoprotective activity of twelve novel 7'-hydroxy lignan glucosides from arctii fructus. | twelve novel 7'-hydroxy lignan glucosides (1-12), including two benzofuran-type neolignans, two 8-o-4' neolignans, two dibenzylbutyrolactone lignans, and six tetrahydrofuranoid lignans, together with six known lignan glucosides (13-18), were isolated from the fruit of arctium lappa l. (asteraceae), commonly known as arctii fructus. their structures were elucidated using spectroscopy (1d and 2d nmr, ms, ir, ord, and uv) and on the basis of chemical evidence. the absolute configurations of compoun ... | 2014 | 25180661 |
| burdock root extracts limit quorum-sensing-controlled phenotypes and biofilm architecture in major urinary tract pathogens. | bacterial biofilms are serious concern in patients infected with urinary tract infections, complicated urinary tract infections and other device-associated infections. microbes within the biofilms are effectively shielded from antibiotics and host immune cells, hence can be treated only with agents which has the potential to disassemble the biofilms. the study is focused on the root extracts of arctium lappa linn. as a source for complementary medicine against three major biofilm forming clinica ... | 2015 | 25226848 |
| increased chemopreventive effect by combining arctigenin, green tea polyphenol and curcumin in prostate and breast cancer cells. | the low bioavailability of most flavonoids limits their application as anti-carcinogenic agents in humans. a novel approach of treatment with a mixture of bioactive compounds that share molecular anti-carcinogenic targets may enhance the effect on these targets at low concentrations of individual compound, thereby overcoming the limitations of reduced bioavailability. we therefore investigated whether a combination of three natural products arctigenin (arc), a novel anti-inflammatory lignan from ... | 2014 | 25243063 |
| arctigenin but not arctiin acts as the major effective constituent of arctium lappa l. fruit for attenuating colonic inflammatory response induced by dextran sulfate sodium in mice. | the crude powder of the fruit of arctium lappa l. (alf) has previously been reported to attenuate experimental colitis in mice. but, its main effective ingredient and underlying mechanisms remain to be identified. in this study, alf was extracted with ethanol, and then successively fractionated into petroleum ether, ethyl acetate, n-butanol and water fraction. experimental colitis was induced by dextran sulfate sodium (dss) in mice. among the four fractions of alf, the ethyl acetate fraction sho ... | 2014 | 25284342 |
| arctiin blocks hydrogen peroxide-induced senescence and cell death though microrna expression changes in human dermal papilla cells. | accumulating evidence indicates that reactive oxygen species (ros) are an important etiological factor for the induction of dermal papilla cell senescence and hair loss, which is also known alopecia. arctiin is an active lignin isolated from arctium lappa and has anti-inflammation, anti-microbial, and anti-carcinogenic effects. in the present study, we found that arctiin exerts anti-oxidative effects on human hair dermal papilla cells (hhdpcs). | 2014 | 25299961 |
| effects of arctium lappa l. (burdock) root tea on inflammatory status and oxidative stress in patients with knee osteoarthritis. | this study was designed to examine the effect of burdock root tea on inflammatory markers and oxidative stress indicators in patients with knee osteoarthritis (oa). | 2016 | 25350500 |
| protective effects of arctium lappa l. roots against hydrogen peroxide-induced cell injury and potential mechanisms in sh-sy5y cells. | accumulated evidence has shown that excessive reactive oxygen species (ros) have been implicated in neuronal cell death related with various chronic neurodegenerative disorders. this study was designed to explore neuroprotective effects of ethyl acetate extract of arctium lappa l. roots (eal) on hydrogen peroxide (h2o2)-induced cell injury in human sh-sy5y neuroblastoma cells. the cell viability was significantly decreased after exposure to 200 μm h2o2, whereas pretreatment with different concen ... | 2015 | 25352420 |
| behavioral and electroantennogram responses of plum curculio, conotrachelus nenuphar, to selected noxious plant extracts and insecticides. | behavioral and electroantennogram responses of plum curculio, conotrachelus nenuphar (herbst) (coleoptera: curculionidae), adults were tested for several methanolic plant extracts and organically approved insecticides. plant extracts were evaluated for their potential as antifeedants or oviposition deterrents. these extract responses were also compared to those elicited by the non-neurotoxic, organic irritant-insecticide kaolin clay. both sexes of plum curculio exhibited antennal response as mea ... | 2014 | 25368046 |
| chemical analysis of raw and processed fructus arctii by high-performance liquid chromatography/diode array detection-electrospray ionization-mass spectrometry. | in traditional chinese medicine (tcm), raw and processed herbs are used to treat the different diseases. fructus arctii, the dried fruits of arctium lappa l. (compositae), is widely used in the tcm. stir-frying is the most common processing method, which might modify the chemical compositions in fructus arctii. | 2014 | 25422559 |
| metabolite profiling of the response of burdock roots to copper stress. | arctium lappa l. (asteraceae), also known as burdock, has a long history of cultivation as a dietary vegetable worldwide. stress in plants disrupts metabolic homeostasis and requires adjustment of metabolic pathways. exposure to heavy metals is one of the most prevalent environmental stresses encountered by plants. in this study, metabolite profiling based on (1)h nmr and gc-ms was used to obtain a holistic view of the response of burdock roots to copper stress. the principal component analysis ... | 2015 | 25578619 |
| arctigenin protects against lipopolysaccharide-induced pulmonary oxidative stress and inflammation in a mouse model via suppression of mapk, ho-1, and inos signaling. | arctigenin, a bioactive component of arctium lappa (nubang), has anti-inflammatory activity. here, we investigated the effects of arctigenin on lipopolysaccharide (lps)-induced acute lung injury. mice were divided into four groups: control, lps, lps + dmso, and lps + arctigenin. mice in the lps + arctigenin group were injected intraperitoneally with 50 mg/kg of arctigenin 1 h before an intratracheal administration of lps (5 mg/kg). lung tissues and bronchoalveolar lavage fluids (balfs) were coll ... | 2015 | 25616905 |
| identification of a dicaffeoylquinic acid isomer from arctium lappa with a potent anti-ulcer activity. | leaves of arctium lappa contain several mono- and dicaffeoylquinic acids, as evaluated by liquid chromatography-mass spectrometry. in order to investigate the protection on gastric mucosa against ulcers, rats were treated with fractions from leaf extract prior to ethanol-induced ulcers. the original fraction obtained as ethanol soluble fraction from hot aqueous extract was able to protect de gastric mucosa, and this effect was retained in the ethyl acetate fraction, obtained from liquid/liquid f ... | 2015 | 25640125 |
| in vitro and in vivo antimutagenic effects of dig, a herbal preparation of berberis vulgaris, taraxacum officinale and arctium lappa, against mitomycin c. | dig, a liquid herbal preparation made from a mixture of diluted mother tinctures of berberis vulgaris, taraxacum officinale and arctium lappa, was assessed for its antimutagenic properties against mitomycin c. the micronucleus assay on chinese hamster ovary (cho)-k1 cells was used to evaluate the in vitro anticlastogenic activity of dig compared to those of separately diluted mother tinctures. the micronucleus assay was performed on mouse erythrocytes and the comet assay was performed on mouse l ... | 2015 | 25666712 |
| quality assessment of raw and processed arctium lappa l. through multicomponent quantification, chromatographic fingerprint, and related chemometric analysis. | in traditional chinese medicine, raw and processed herbs are used to treat different diseases. suitable quality assessment methods are crucial for the discrimination between raw and processed herbs. the dried fruit of arctium lappa l. and their processed products are widely used in traditional chinese medicine, yet their therapeutic effects are different. in this study, a novel strategy using high-performance liquid chromatography and diode array detection coupled with multivariate statistical a ... | 2015 | 25678337 |
| natural lignans from arctium lappa modulate p-glycoprotein efflux function in multidrug resistant cancer cells. | arctium lappa is a well-known traditional medicinal plant in china (tcm) and europe that has been used for thousands of years to treat arthritis, baldness or cancer. the plant produces lignans as secondary metabolites which have a wide range of bioactivities. yet, their ability to reverse multidrug resistance (mdr) in cancer cells has not been explored. in this study, we isolated six lignans from a. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)lappaol a, lappaol c, and lappaol f. ... | 2015 | 25765837 |
| four new neolignan glucosides from the fruits of arctium lappa. | four new neolignan glucosides named (7s, 8r)-4,7,9,9'-tetrahydroxy-3,3'-dimethoxy-8-o-4'-neolignan-9'-o-β-d-apiofuranosyl-(1 → 6)-o-β-d-glucopyranoside (1), (8r)-4,9,9'-trihydroxy-3,3'-dimethoxy-7-oxo-8-o-4'-neolignan-4-o-β-d-glucopyranoside (2), (7r, 8s)-dihydrodehydrodiconiferyl alcohol-7'-oxo-4-o-β-d-glucopyranoside (3), and (7's, 8'r, 8s)-4,4',9'-trihydroxy-3,3'-dimethoxy-7',9-epoxylignan-7-oxo-4-o-β-d-glucopyranoside (4) were isolated from the fruits of arctium lappa l. their structures and ... | 2015 | 25978776 |
| effects of hydro-alcoholic extract from arctium lappa l. (burdock) root on gonadotropins, testosterone, and sperm count and viability in male mice with nicotinamide/ streptozotocin-induced type 2 diabetes. | reproductive dysfunction is a complication of diabetes. arctium lappa (burdock) root has hypoglycemic and antioxidative properties, which are traditionally used for treatment of impotence and sterility. therefore, the aim of this study is to investigate the effects of its hydro alcoholic extract on gonadotropin, testosterone, and sperm parameters in nicotinamide/ streptozotocin-induced diabetic mice. | 2017 | 26023292 |
| arctigenin exerts anti-colitis efficacy through inhibiting the differentiation of th1 and th17 cells via an mtorc1-dependent pathway. | arctigenin, the main effective constituent of arctium lappa l. fruit, has previously been proven to dramatically attenuate dextran sulfate sodium (dss)-induced colitis in mice, a frequently used animal model of inflammatory bowel disease (ibd). as th1 and th17 cells play a crucial role in the pathogenesis of ibd, the present study addressed whether and how arctigenin exerted anti-colitis efficacy by interfering with the differentiation and activation of th1/th17 cells. in vitro, arctigenin was s ... | 2015 | 26074264 |
| [spectrum-effect relationship between total antioxidant activity and hplc fingerprint of arctium lappa root]. | to explore the spectrum-effect relationship between the hplc fingerprint of arctium lappa root methanol extract and the total antioxidant activity. | 2014 | 26080501 |
| compound mqa, a caffeoylquinic acid derivative, protects against nmda-induced neurotoxicity and potential mechanisms in vitro. | compound mqa (1,5-o-dicaffeoyl-3-o-[4-malic acid methyl ester]-quinic acid) is a natural derivative of caffeoylquinic acid isolated from arctium lappa l. roots. however, we know little about the effects of mqa on the central nervous system. this study aims to investigate the neuroprotective effects and underlying mechanisms of mqa against the neurotoxicity of n-methyl-d-aspartate (nmda). | 2015 | 26096046 |
| natural lignans from arctium lappa as antiaging agents in caenorhabditis elegans. | arctium lappa is a well-known traditional medicinal plant in china (tcm) and europe that has been used for thousands of years to treat arthritis, baldness or cancer. the plant produces lignans as secondary metabolites, which have a wide range of bioactivities. yet, their antiaging potential has not been explored. in this study, we isolated six lignans from a. lappa seeds, namely arctigenin, matairesinol, arctiin, (iso)lappaol a, lappaol c, and lappaol f. the antioxidant and antiaging properties ... | 2015 | 26141518 |
| new butyrolactone type lignans from arctii fructus and their anti-inflammatory activities. | arctiidilactone (1), a novel rare butyrolactone lignan with a 6-carboxyl-2-pyrone moiety, and 11 new butyrolactone lignans (2-12) were isolated from the fruits of arctium lappa l., together with 5 known compounds (13-17). their structures were elucidated by interpretation of their spectroscopic data (1d and 2d nmr, uv, ir, ord, and hresims) and comparison to literature data. the absolute configurations of compounds 1-12 were determined by a combination of rotating-frame nuclear overhauser effect ... | 2015 | 26312555 |
| [study on high-yield cultivation measures for arctii fructus]. | to find out the high yield cultivation measures for arctii fructus. | 2015 | 26415394 |
| arctigenin suppress th17 cells and ameliorates experimental autoimmune encephalomyelitis through ampk and ppar-γ/ror-γt signaling. | arctigenin is a herb compound extract from arctium lappa and is reported to exhibit pharmacological properties, including neuronal protection and antidiabetic, antitumor, and antioxidant properties. however, the effects of arctigenin on autoimmune inflammatory diseases of the cns, multiple sclerosis (ms), and its animal model experimental autoimmune encephalomyelitis (eae) are still unclear. in this study, we demonstrated that arctigenin-treated mice are resistant to eae; the clinical scores of ... | 2016 | 26440666 |
| arctigenin, a potent ingredient of arctium lappa l., induces endothelial nitric oxide synthase and attenuates subarachnoid hemorrhage-induced vasospasm through pi3k/akt pathway in a rat model. | upregulation of protein kinase b (pkb, also known as akt) is observed within the cerebral arteries of subarachnoid hemorrhage (sah) animals. this study is of interest to examine arctigenin, a potent antioxidant, on endothelial nitric oxide synthase (enos) and akt pathways in a sah in vitro study. basilar arteries (bas) were obtained to examine phosphatidylinositol-3-kinase (pi3k), phospho-pi3k, akt, phospho-akt (western blot) and morphological examination. endothelins (ets) and enos evaluation ( ... | 2015 | 26539501 |
| use of arctium lappa extract against acetaminophen-induced hepatotoxicity in rats. | severe destructive hepatic injuries can be induced by acetaminophen overdose and may lead to acute hepatic failure. | 2015 | 26543508 |
| arctigenin reduces blood pressure by modulation of nitric oxide synthase and nadph oxidase expression in spontaneously hypertensive rats. | arctigenin is a bioactive constituent from dried seeds of arctium lappa l., which was traditionally used as medicine. arctigenin exhibits various bioactivities, but its effects on blood pressure regulation are still not widely studied. in this study, we investigated antihypertensive effects of arctigenin by long-term treatment in spontaneously hypertensive rats (shrs). arctigenin (50 mg/kg) or vehicle was administered to shrs or wistar rats as negative control by oral gavage once a day for total ... | 2015 | 26585490 |
| inhibitory effect of fermented arctium lappa fruit extract on the ige-mediated allergic response in rbl‑2h3 cells. | arctium lappa fruit has been used in traditional medicine, and it is known to exert beneficial effects, such as antioxidant, anti-inflammatory and anticancer effects. however, the effects of the arctium lappa fruit on the allergic response remain unknown. in this study, we evaluated the anti-allergic effects of arctium lappa fruit extract (afe) and its fermented form (f-afe) using immunoglobulin e (ige)-activated rbl‑2h3 cells. to investigate the anti-allergic effects of afe or f-afe, we examine ... | 2016 | 26707911 |
| protective effects of arctium lappa l. root extracts (ares) on high fat diet induced quail atherosclerosis. | this study was designed to evaluate the protective effects of arctium lappa l. root extracts (ares) from different extraction methods (aqueous, ethanol, chloroform and flavone) on atherosclerosis. | 2016 | 26746431 |
| effects of arctium lappa on cadmium-induced damage to the testis and epididymis of adult wistar rats. | the protective role of arctium lappa (al) on the testes of rats acutely exposed to cadmium (cd) was tested. the rats were randomly divided into a control group (c-group) and three major experimental groups, which were further subdivided into minor groups (n = 6) according to the experimental period (7 or 56 days). the c-group was subdivided into c-7 and c-56 [receiving a single saline solution, intraperitoneal (i.p.), on the first day]; the al-group, al-7, and al-56, received al extract (300 mg/ ... | 2016 | 26926909 |
| two new compounds from the fruits of arctium lappa. | phytochemical investigation of the extract of arctii fructus led to the isolation and characterization of two new compounds, named arctiisesquineolignan b (1) and arctiiphenolglycoside a (2). their structures were elucidated by means of spectroscopic methods (uv, ir, hr-esi-ms, 1d and 2d nmr) and chemical evidence, as well as by comparison with known analogs in the literature. compound 2 exhibited stronger antioxidant activity than the positive control ascorbic acid at a concentration of 10 μm. | 2016 | 26981771 |
| usefulness of different vascular plant species for passive biomonitoring of mediterranean rivers. | choosing native vascular plants as nutrient and toxic element accumulators for passive biomonitoring of urban river quality is not an easy task in mediterranean rivers, due to the particular climate determining high variations in river hydrology. to identify potential biomonitors for this area, the roots of seven species (angelica sylvestris, apium nodiflorum, tradescantia fluminensis, nasturtium officinale, persicaria lapathifolia, arctium lappa, typha latifolia), growing in seven sites along t ... | 2016 | 27040538 |
| antiallergic activity of ethanol extracts of arctium lappa l. undried roots and its active compound, oleamide, in regulating fcεri-mediated and mapk signaling in rbl-2h3 cells. | the antiallergic potential of arctium lappa l. was investigated in sprague-dawley rats, icr mice, and rbl-2h3 cells. ethanol extract (90%) of a. lappa (ale, 100 μg/ml) inhibited the degranulation rate by 52.9%, determined by the level of β-hexosaminidase. ale suppressed passive cutaneous anaphylaxis (pca) in rats and attenuated anaphylaxis and histamine release in mice. to identify the active compound of ale, we subsequently fractionated and determined the level of β-hexosaminidase in all subfra ... | 2016 | 27087645 |
| the antiviral activity of arctigenin in traditional chinese medicine on porcine circovirus type 2. | arctigenin (act) is a phenylpropanoid dibenzylbutyrolactone lignan extracted from the traditional herb arctium lappa l. (compositae) with anti-viral and anti-inflammatory effects. here, we investigated the antiviral activity of act found in traditional chinese medicine on porcine circovirus type 2 (pcv2) in vitro and in vivo. results showed that dosing of 15.6-62.5μg/ml act could significantly inhibit the pcv2 proliferation in pk-15 cells (p<0.01). dosing of 62.5μg/ml act 0, 4 or 8h after challe ... | 2016 | 27234554 |
| natural cures for breast cancer treatment. | for centuries, herbs and plants have been used for medicinal purposes and as food as well. this review concerns about different types of plants that retain the immune stimulating and anti-tumor properties. large variety of active phytochemicals such as carotenoids, flavonoids, ligands, polyphenolics, terpenoids, sulfides, lignans and plant sterols has been identified in different types of herbs. these phytochemicals have different mechanisms of action. they either stimulate the protective enzyme ... | 2016 | 27275107 |
| beneficial effect of dietary fiber on the upper gastrointestinal transit time in rats suffering from a toxic dose of amaranth. | gobo dietary fiber (gdf) obtained from the roots of edible burdock (arctium lappa l.) was examined for its protective role against amaranth (food red no. 2, am) toxicity in the upper gastrointestinal tract (from the mouth to the ileal end) of rats. ileorectostomized rats were examined for their growth response to feeding with a purified basal diet containing 4% am with or without 7.5% gdf. the transit half-time (tt50) through the upper gastrointestinal tract was also examined with ileostomized r ... | 1992 | 27280645 |
| polysaccharides from arctium lappa l.: chemical structure and biological activity. | the plant arctium lappa l. is popularly used to relieve symptoms of inflammatory disorders. a crude polysaccharide fraction (saa) resulting of aqueous extraction of a. lappa leaves showed a dose dependent anti-edematogenic activity on carrageenan-induced paw edema, which persisted for up to 48h. sequential fractionation by ultrafiltration at 50kda and 30kda cut-off membranes yielded three fractions, namely rf50, rf30, and ef30. all these maintained the anti-edematogenic effect, but rf30 showed a ... | 2016 | 27311502 |
| purification and characterization of arctium lappa l. (edible burdock) polyphenol oxidase. | polyphenol oxidase of arctium lappa l. (edible burdock) has been purified by chromatographies on deae-cellulose, sephadex g-75, and phenyl-cellulofine to a homogeneous state as judged by sds polyacrylamide gel electrophoresis. the molecular weight of the purified enzyme was estimated to be 31,000 by sds-page and 25,000 by gel filtration on tskgel g2000sw. the optimum ph was 7.0 and the enzyme was stable at ph 7.0-9.0. the enzyme oxidized triphenols such as pyrogallol and phloroglucinol, and was ... | 1993 | 27314765 |
| stereochemical difference in secoisolariciresinol formation between cell-free extracts from petioles and from ripening seeds of arctium lappa l. | cell-free extracts from ripening seeds of arctium lappa l. catalyzed the enantioselective formation of (-)-pinoresinol, (-)-lariciresinol and (-)-secoisolariciresinol from achiral coniferyl alcohol in the presence of nadph and h2o2. the enantioselectivity of the lignan formation was opposite to that of the (+)-secoisolariciresinol formation catalyzed by cell-free extracts from petioles of the same plant species. | 1998 | 27397009 |
| antibacterial, antibiofilm effect of burdock (arctium lappa l.) leaf fraction and its efficiency in meat preservation. | first, the antibacterial, antibiofilm effect and chemical composition of burdock (arctium lappa l.) leaf fractions were studied. then, the efficiency of burdock leaf fractions in pork preservation was evaluated. the results showed that burdock leaf fraction significantly inhibited the growth and biofilm development of escherichia coli and salmonella typhimurium. mics of burdock leaf fractions on e. coli and salmonella typhimurium were both 2 mg/ml. at a concentration of 2.0 mg/ml, the inhibition ... | 2016 | 27497128 |
| the immunomodulatory potential of selected bioactive plant-based compounds in breast cancer: a review. | breast cancer has continued to cause high cancer death rates among women worldwide. the use of plants' natural products in breast cancer treatment has received more attention in recent years due to their potentially wider safety margin and the potential to complement conventional chemotherapeutic drugs. plant-based products have demonstrated anticancer potential through different biological pathways including modulation of the immune system. immunomodulatory properties of medicinal plants have b ... | 2016 | 27539316 |
| new phytochemicals as potential human anti-aging compounds: reality, promise, and challenges. | aging is an inevitable process influenced by genetic, lifestyle and environmental factors. indirect evidence shows that several phytochemicals can have anti-aging capabilities, although direct evidence in this field is still limited. this report aims to provide a critical review on aspects related to the use of novel phytochemicals as anti-aging agents, to discuss the obstacles found when performing most anti-aging study protocols in humans, and to analyze future perspectives. in addition to the ... | 2016 | 27623718 |
| phase i trial of gbs-01 for advanced pancreatic cancer refractory to gemcitabine. | gbs-01, an extract from the fruit of arctium lappa l. is an orally administered drug rich in arctigenin, which has been reported to exert antitumor activity by attenuating the tolerance of cancer cells to glucose deprivation. we investigated the maximum tolerated dose of gbs-01 based on the frequency of the dose-limiting toxicities (dlts) and pharmacokinetics in patients with advanced pancreatic cancer refractory to gemcitabine. gbs-01 was given orally at escalating doses from 3.0 g (containing ... | 2016 | 27685612 |
| pretreatment of mqa, a caffeoylquinic acid derivative compound, protects against h2o2-induced oxidative stress in sh-sy5y cells. | compound mqa (1,5-o-dicaffeoyl-3-o-[4-malic acid methyl ester]-quinic acid) is a natural caffeoylquinic acid derivative isolated from arctium lappa l. roots. this study aims to explore the neuroprotective effects of mqa against hydrogen peroxide (h2o2)-induced oxidative stress in sh-sy5y neuroblastoma cells. | 2016 | 27800716 |
| the effect of burdock leaf fraction on adhesion, biofilm formation, quorum sensing and virulence factors of pseudomonas aeruginosa. | this study aimed to evaluate the effect of a fraction of burdock (arctium lappa l.) leaf on the initial adhesion, biofilm formation, quorum sensing and virulence factors of pseudomonas aeruginosa. | 2017 | 27860087 |
| arctigenin inhibits stat3 and exhibits anticancer potential in human triple-negative breast cancer therapy. | triple-negative breast cancers (tnbcs) are the most aggressive and hard-to-treat breast tumors with poor prognosis, and exploration for novel therapeutic drugs is impending. arctigenin (atn), a bioactive lignan isolated from seeds of arctium lappa l, has been reported to inhibit many cancer types; however, the effect of atn on tnbc remains unclear. in this study, we demonstrated that atn decreased proliferation, and induced apoptosis in tnbc cells. furthermore, we explored the underlying mechani ... | 2017 | 27861147 |
| therapeutic effect of arctium lappa in schistosoma haematobium associated kidney disturbance: biochemical and molecular effects. | schistosoma haematobium (s. haematobium) infection has been found to be strongly associated with bladder cancer, which necessitates for discover of a natural new therapeutic agent. the aim of this study was to evaluate the therapeutic effect of arctium lappa seed extract in s. haematobium associated kidney disturbance. forty male albino mice were used and divided into four equal groups; group 1 control includes non-infected healthy mice, groups 2, 3 and 4 subcutaneous infected with s. haematobiu ... | 2016 | 27876925 |
| arctigenin, a lignan from arctium lappa l., inhibits metastasis of human breast cancer cells through the downregulation of mmp-2/-9 and heparanase in mda-mb-231 cells. | arctigenin is a bioactive lignan isolated from the seeds of arctium lappa l. which has been widely used as a diuretic and a diaphoretic in traditional chinese medicine. in the present study, the authors investigated the effects of arctigenin on tumor migration and invasion in aggressive human breast cancer cells. the mtt assay results showed that arctigenin did not show a significant cytotoxic effect on the cell viability of mda-mb-231 cells. however, wound healing migration and boyden chamber i ... | 2017 | 27878294 |
| gastroprotective effects of arctigenin of arctium lappa l. on a rat model of gastric ulcers. | in the present study, the gastroprotective effects of arctigenin of fructus arctii were evaluated and the possible underlying mechanisms of action were elucidated. arctigenin (high-performance liquid chromatography purity, >99.0%) was isolated and purified from the seeds of arctium lappa l. the anti-ulcerogenic activity of arctigenin against ulcers induced by absolute ethanol and acetic acid was evaluated in a sprague-dawley rat model. in addition, the antioxidant activity was assessed by measur ... | 2016 | 27882222 |
| anti-obesity effects of arctii fructus (arctium lappa) in white/brown adipocytes and high-fat diet-induced obese mice. | arctii fructus is traditionally used in oriental pharmacies as an anti-inflammatory medicine. although several studies have shown its anti-inflammatory effects, there have been no reports on its use in obesity related studies. in this study, the anti-obesity effect of arctii fructus was investigated in high-fat diet (hfd)-induced obese mice, and the effect was confirmed in white and primary cultured brown adipocytes. arctii fructus inhibited weight gain and reduced the mass of white adipose tiss ... | 2016 | 27882370 |
| room temperature ionic liquids-based salting-in strategy for counter-current chromatography in the separation of arctiin. | counter-current chromatography (ccc) is a solid support-free liquid-liquid partition chromatography and has wide applications. however, ccc separation is still a challenging process and the selection of appropriate solvent system for separation of target compound(s) is still relatively time-consuming. in this work, we introduced a room temperature ionic liquids-based salting-in strategy for the rapid selection of suitable solvent systems for ccc separation. in the randomly selected solvent syste ... | 2016 | 27932083 |
| the anti-metastatic effects of the phytoestrogen arctigenin on human breast cancer cell lines regardless of the status of er expression. | arctigenin is a plant lignan extracted from arctium lappa that has been shown to have estrogenic properties. in spite of the health benefits of phytoestrogens reducing the risk of osteoporosis, heart disease, and menopausal symptoms, its benefits against the risk of breast cancer have not been fully elucidated. thus, we investigated the effects of arctigenin on metastasis of breast cancer using both estrogen receptor (er)-positive mcf-7 and er-negative mda-mb-231 human breast cancer cell lines t ... | 2017 | 28035371 |
| protective effect of arctigenin on ethanol-induced neurotoxicity in pc12 cells. | as a neurotropic substance, ethanol can damage nerve cells through an increase in the production of free radicals, interference of neurotrophic factor signaling pathways, activation of endogenous apoptotic signals and other molecular mechanisms. previous studies have revealed that a number of natural drugs extracted from plants offer protection of nerve cells from damage. among these, arctigenin (atg) is a lignine extracted from arctium lappa (l.), which has been found to exert a neuroprotective ... | 2017 | 28260103 |
| effect of using different vehicles on the physicochemical, antimicrobial, and biological properties of white mineral trioxide aggregate. | this study evaluated the physicochemical, antimicrobial, and biological properties of white mineral trioxide aggregate (mta) mixed with aqueous and propylene glycol extracts of arctium lappa l. and casearia sylvestris sw. | 2017 | 28320540 |
| antidiabetic, hypolipidemic and hepatoprotective effects of arctium lappa root's hydro-alcoholic extract on nicotinamide-streptozotocin induced type 2 model of diabetes in male mice. | arctium lappa (burdock), (a. lappa) root has hypoglycemic and antioxidative effects, and has been used for treatment of diabetes in tradition medicine. this study was conducted to evaluate the antidiabetic and hypolipidemic properties of a. lappa root extract on nicotinamide-streptozotocin (na-stz)-induced type2 diabetes in mice. | 2017 | 28348972 |