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a case of hematometra infected by listeria monocytogenes.a case of listeria infection is reported of a 10 year old girl with symptoms of the first menstruation but without the discharge of blood because of the absence of the vaginal duct. the blood retained in the uterus obtained by puncture through the rectum contained listeria monocytogenes 4b. the infection was possibly acquired from a household pet.1979113954
listeriosis in sheep. listeria monocytogenes excretion and immunological state in healthy sheep. 1979114002
[specific soluble antigens and listeria monocytogenes typing by electrosyneresis (author's transl)].listeria monocytogenes releases its antigens during the exponential phase. electrosyneresis on agarose allows detection of these antigens in the supernatant of broth culture following a 3 h incubation of the strains. this serotyping method seems to be easy, rapid and reproductible. the authors have investigated 83 strains of different origines and find no difference with agglutination. however, during the stationary phase, l. monocytogenes releases other antigens which gave precipitation lines w ...1979114080
arthritis due to listeria monocytogenes. 1979114181
[listeria monocytogenes in newborn infants; an organism causing sepsis and meningitis]. 1979114867
active or passive acquired resistance after mycobacterium lepraemurium infection in c57bl/6 and c3h/hen mice. 1979115377
stimulation of cell-mediated resistance in mice to infection with listeria monocytogenes by vitamin a.vitamin a given as retinol-acetate, retinol-palmitate as well as the derivates retinoic acid and a retinoid, strongly fortified the resistance of mice to infection with virulent cells of listeria monocytogenes. however, strong enhancement of resistance was only achieved when high toxic doses of vitamin a were given. apparently, this effect was due to a stimulation of the function of the mononuclear phagocytic system rather than of the t lymphocyte.1979115378
long-term culture of canine peripheral blood monocytes in vitro.various cultural conditions were assessed for their ability to maintain canine peripheral blood monocytes in vitro. approximately ten days after incubation of peripheral blood leukocytes in earle's minimum essential medium supplemented with homologous red cell lysates and normal horse serum, virtually a pure macrophage culture was obtained which could then be maintained for about two months. this culture was judged to be pure by surface marker analysis and their phagocytic activity. the number o ...1979115559
purification of a surface-specific soluble antigen from listeria monocytogenes.a complex antigenic preparation obtained from listeria monocytogenes serovariant 4b by freeze-pressing, centrifugation, and gel filtration treatment was studied by crossed immunoelectrophoresis, with the aim of preparing an antigenic fraction that could be used to investigate the serological response to listeric infection. of 17 immunoprecipitates revealed in the soluble extract, one of three major antigens (designated antigen 2) was shown to be a strong antigen in humans or rabbits infected wit ...1979115793
response to therapy in an experimental rabbit model of meningitis due to listeria monocytogenes.a uniformly fatal, reproducible model of experimental meningitis due to listeria monocytogenes was developed in rabbits for study of the natural progression of the disease and was used to evaluate treatment regimens. bacterial titers in cerebrospinal fluid and pleocytosis approximated those found in humans. therapeutic studies in vivo revealed that rifampin was less rapidly bactericidal than ampicillin or penicillin, the agents usually recommended for treatment of meningitis; that penicillin plu ...1979115932
the specific binding of listeria monocytogenes-immune t lymphocytes to macrophages. i. quantitation and role of h-2 gene products.a system was developed to study the binding of listeria monocytogenes-specific t cells to l. monocytogenes-pulsed macrophages as an analogue of the initial phase of t-cell activation: antigen recognition. specific binding, demonstrable after a brief (1 h) contact, was quantitated by the depletion of l. monocytogenes-specific t-cell activity in the cells nonadherent to l. monocytogenes-pulsed macrophage monolayers. l. monocytogenes-specific t-cell function was measured by its ability to activate ...1979115958
partial characterization of anti-tumor effector macrophages in the peritoneal cavities of concomitantly immune mice and mice injected with macrophage-stimulating agents. 1979115998
[a case of listeria meningoencephalitis]. 1978116339
listeriosis in sheep. listeria monocytogenes excretion and immunological state in sheep in flocks with clinical listeriosis. 1979116488
age-related defense against infection with intracellular pathogens.young adult (6--12 weeks old) and aged (20--24 months old) nmri mice were infected with various intracellular parasites. the following results were obtained: (1) after a sublethal infection with listeria monocytogenes, aged mice were found to show a resistance similar to that of young adults. a challenge infection with this pathogen was followed by specific immunity of long duration in both age-groups. (2) on the other hand, young animals were significantly more resistant to salmonella typhimuri ...1979116909
specific lyt 123 cells are involved in protection against listeria monocytogenes and in delayed-type hypersensitivity to listerial antigens.specific anti-lyt antisera and complement were used to determine the lyt phenotype of peritoneal exudate t lymphocytes from listeria monocytogenes-immune mice. it was found that lyt 123+ t cells are crucially involved both in protection against listerial infection and in delayed-type hypersensitivity (dth) to listerial antigens. thus, both functions critically depend on a t-cell subclass phenotypically different from that which mediates dth to noninfectious antigens and help in antibody formatio ...1979117073
use of selective agents for the isolation of listeria monocytogenes. 1979117274
listeria monocytogens: synergistic effects of ampicillin and gentamicin.listeria monocytogenes infections are most common in newborn infants and persons with impaired defense mechanisms. there are reports of successful treatment with ampicillin alone: however, there is uncertainty as to what regimen constitutes the most effective therapy. the purpose of this study was to illustrate the in-vitro synergism between ampicillin and gentamicin against l. monocytogenes. seven strains of l. monocytogenes isolated from bloods or cerebrospinal fluids of infants and three cont ...1979117697
[listeria enzootic in newborn lambs].epizootological, clinical and pathomorphological studies were made of a meningo-encephalitic form of listeriotic enzooty in new born lambs. the clinical symptoms as well as the patho-anatomical and patho-histological changes in the brain and in the inner organs of dead lambs were described. arisal of enzooty was connected with the inclusion of silage in the daily ration of ewes. it was assumed also that infection of suckling lambs possible by the milk of diseased mother-ewes also and in the pren ...1979118579
differing contribution of polymorphonuclear cells and macrophages to protection of mice against listeria monocytogenes and pseudomonas aeruginosa.bacterial growth and lethality of listeria monocytogenes in mice were augmented by carrageenan-treatment and x-irradiation (8 j kg-1), whereas growth and lethality of pseudomonas aeruginosa were augmented by x-irradiation but not by carrageenan-treatment. protection against l. monocytogenes, at least in the early phases, appears to depend mainly on macrophages, since carrageenan depletes macrophages but not polymorphonuclear cells (pmn), whereas protection against p. aeruginosa appears to depend ...1979119029
[bacteriophage typing of 823 "listeria monocytogenes" strains isolated in france from 1958 to 1978 (author's transl)].this study was undertaken to establish a typing scheme for listeria monocytogenes. a total of 823 strains, isolated in france from 1958 to 1978, were studied; 69.4% of these belonged to serotype 4. using a set of 20 phages, the lytic activity, frequency and specific character of these phages were estimated and phage typing carried out. we were able to define a phage typing system for l. monocytogenes using 12 principal phages and 3 secondary phages. in order to discriminate phages types within s ...1979119457
immunostimulating effect of listeria monocytogenes, bcg and their biologically active extracts on the model of mouse ascites tumors. 1979120515
[differentiation of nonspecific serological reactions in brucellosis].differentiation of non-specific agglutination was performed by the complement binding reaction, coombs' reaction, hajdu reaction, the surface fixation and agglutination reaction and the reaction of complement binding with heterologic antigens. for that purpose the following were used: 1) serums--antiglobulin against cattle globulin, 5720 serum of various animals which had manifested non-specific agglutination with brucella antigen and brucella serums of experimentally infected sheep, of naturall ...1979120633
comparison of brucella abortus and brucella melitensis infections of mice and their effect on acquired cellular resistance.by using mice infected with strains of brucella abortus and brucella melitensis we examined the histological responses to infection, the relationship of histology to persistence of organisms, and the relation of persistence of organisms to the acquisition of acquired cellular resistance (acr). infection with b. abortus resulted in well-formed granulomas in the livers, which persisted for more than 30 days. in contrast, infection with b. melitensis produced microabscesses in the livers which reso ...1979121113
[biological action of triton x-100 on pathogenic bacteria]. 1979121195
influence of lipids from listeria monocytogenes on the course of infections due to some gram-positive bacteria in mice.the influence of lipids from listeria monocytogenes on the course of infections due to some gram-positive cocci streptococcus pyogenes, streptococcus faecalis and staphylococcus aureus and l. monocytogenes was studied in white mice. varying doses of the lipid preparation were administered before infection. mortality of the animals and rate of elimination of the bacteria from the organs and blood circulation were recorded. in appropriate doses, the lipids markedly enhanced resistance to the afore ...1979121229
[increased catabolism of antigen and enhanced recruitment of antigen-sensitive cells by activation of macrophages with a bacterial phospholipid extract (ebp) (author's transl)].intravenous (iv) infection of a bacterial phospholipid extract (ebp) 24 h before iv immunization of mice with sheep red blood cells has modified the specific immune response. a decrease of the response evaluated by the number of rosette-forming cells was observed after the larger doses of ebp. this effect appeared secondarily to an increased catabolism of antigen. infection of a medium sized dose of ebp directly into the portal vein induced a decreased response by enhancing antigen phogocytosis ...1979121519
[meningoencephalitis caused by listeria monocytogenes in adults. description of 2 cases].two patients are presented who had listeria meningo-encephalitis. they were both adults and reduced in defences against infections. the diagnosis was made by isolation of listeria monocytogenes from cerebrospinal fluid cultures. one of the patients recovered; other died although therapeutic measures were promptly started. the authors suggest the need for a careful research about listeria infections in our country.1979121687
protection of mice against babesia microti with cord factor, coam, zymosan, glucan, salmonella and listeria.cord factor (trehalose 6-6' dimycolate). coam (chlorite-oxidized oxyamylose), zymosan, glucan, salmonella enteritidis 11rx and listeria monocytogenes were found to protect mice against subsequent infection with babesia microti, an intra-erythrocytic protozoan parasite. this protection was not observed after injection of staphylococcus epidermidis, a viridans group streptococcus, thioglycollate, or colloidal carbon. all the agents which protect against b. microti have also been reported to induce ...1979121772
[2 cases of listeriosis in newborn infants]. 1979121898
[listeria monocytogenes findings in raw materials of animal origin (author's transl)]. 1975124215
effect of tilorone treatment on intracellular microbial infections in specific-pathogen-free mice.specific-pathogen-free cd-1 mice were treated orally with the drug tilorone (2,7-bis[2-diethylaminoethoxy]fluoren-9-one hydrochloride) at dosages of 10 or 100 mg per kg of body weight. drug was given 24 h before challenge and then every other day for up to 15 days. growth of sublethal doses of listeria monocytogenes, mycobacterium bovis (bcg montreal), m. tuberculosis h37rv, and salmonella enteritidis in the livers and spleens of intravenously challenged mice was significantly increased compared ...1975125066
effect of oral niridazole treatment on some bacterial infections in mice.treatment of specific-pathogen-free cd-1 mice with oral doses of 10 or 100 mg of niridazole per kg of body weight given 24 h before challenge and then every other day for up to 15 days altered the growth curves for listeria monocytogenes, mycobacterium bovis (bcg montreal), m. tuberculosis h37rv, and salmonella enteritidis seen in the livers and spleens of the treated animals. niridazole in an oral dosage of 10 mg/kg reduced (but did not eliminate) tuberculin hypersensitivity in the mycobacteria ...1975125067
[effect of attenuated listeria monocytogenes cultures on the development of a sarcoma graft, mouse mammary epitheliomas and a dog carcinoma].the injection of attenuated listeria monocytogenes culture together with bp8 sarcoma cells into c3h mice prevented the taking of the graft. moreover, the intratumoral injection of attenuated listeria doubled the survival time of the animals and, in one case a regression of the tumour was observed. after intratumoral injection, in three out of five mice, the mammary carcinoma disappeared, and the course of a gingival carcinoma in a dog was slowed down.1975126749
[listeria monocytogenes isolation at work places in the meat industry (author's transl)]. 1977137775
bacteriological and histopathological evaluation of guinea pigs after infection with listeria monocytogenes.randomly bred guinea pigs were infected with listeria monocytogenes using the intracardial, intravenous and intraperitoneal routes of infection. doses of listeria ranged from 5 to 1,000 x the 50% lethal dose based on the 50% lethal dose for intracardially injected listeria. a complete necropsy was performed on all animals that died after infection. gross and microscopic examination of tissues revealed major pathological features which include myocarditis, edema and congestion with interstitial p ...1977140150
[ultrastructure of listeria monocytogenes bacteriophages].no morphological differences were found among the 10 listeria phages suspensions examined. the polyhedric head appears to be about 62-66 nm in diameter, the tail devoided of contractile sheath measures 260-280 x 10 nm. the phage adsorption is observed on the cell-wall of listeria.1977142575
comparison of t cell-mediated immune responsiveness of nzb, (nzb x &nzw)f1 hybrid and other murine strains.the age-dependent capacity of nzb and (nzb x nzw)f1 hybrid, balb/c, dba/2, c57bl/6 and c3h mice to generate t cell-mediated immune responses was assessed qualitatively and quantitatively by measuring the following effector functions: (a) the time course of alloreactive cytotoxic t-cell activity triggered in vitro was comparable for nz and other mouse strains; cell reactivity generated in vivo against el4 tumour cells was low in young (nzb x nzw)f1 mice and in dba/2 mice but was comparable for ol ...1977142594
[listeria monocytogenes (welshimer strain) application to induce an acquired resistance to listeriosis and mycobacterial infections (author's transl)]. 1978149596
in vitro induction of cell-mediated immunity to murine leukemia cells. vii. methods for augmenting the induction and expression of cytotoxic response in vitro to syngeneic tumors. 1979155712
[incidence of listeria monocytogenes in faeces of employees of meat processing plants and meat shops (author's transl)]. 1979156084
[the problem of speciality of lal test in bacterial endotoxin-like substances (author's transl)]. 1979158437
t cell-mediated immune responses of lupus-prone bxsb mice and other murine strains.cellular-mediated immunity in the newly described bxsb strain of mice, which is prone to autoimmune disease, has been compared with that of two other strains, c57bl/6 and 129/j. quantificaiton of cytotoxic t cell responses to alloantigens and viruses (lymphocytic choriomeningitis and vaccinia virus) showed no difference in the kinetics of appearance and relative activity of cytotoxic t cells per spleen between the young and old bxsb and the control mice. the t cell-dependent primary footpad swel ...1979159146
antitumor activity of bacterial infection. ii. effect of listeria monocytogenes on growth of a guinea pig hepatoma.growth of a guinea pig hepatoma was suppressed when tumor cells were mixed with viable listeria monocytogenes (lm) before intradermal (id) injection into syngeneic recipients. heat-killed lm were less effective than viable organisms in suppressing tumor growth. a vaccine containing oil droplets and lm cell walls lacked antitumor activity. intratumor injection of viable lm on the 7th day after id injection of tumor cells prolonged survival of guinea pigs that did not succumb to lm infection. afte ...1975164568
[ultrastructure of l-forms. ii. l-forms of listeria monocytogenes].a study was made of ultrathin sections of the stable l-forms of listeria obtained under the action of penicillin in meat-peptone-liver broth. a marked cellular polymorphism was found in the l-form culture: within the same colony cells differed in size, shape and fine structure. it is supposed that polymorphism could be partially explained by a different plasticity and premeability of cytoplasmic membrane in different types of cells of the same l-colony. the three-layer structure of the membrane ...1975164746
specific immunity and nonspecific resistance to infection: listeria, protozoa, and viruses in mice and hamsters,.specific immunity developed by mice against protozoan (toxoplasma gondii and besnoitia jellisoni) and bacterial (listeria monocytogenes) infections was compared with nonspecific protection conferred by prior infections. the results indicated that homologous immunity protected mice from more than 10-5 ld50 of t. gondii or b. jellisoni, but from only 10-2 ld50 of l. monocytogenes. heterospecific protection among these organisms was for 10-0.4 minus 10-1.2 ld50. in studies in hamsters specific immu ...1975165241
the effects of protein deprivation on cell-mediated immunity.the effect of protein insufficiency on immune responsiveness was investigated in inbred mice fed isocaloric diets low and normal in protein. mice were tested for aberrations of cell-mediated and humoral immunities. protein insufficiency enhances cell-mediated immunity while depressing or not affecting humoral immunity. cell-mediated immunity was enhanced in testing: allogeneic skin graft rejection, spleen cell responsiveness to phytohemagglutinin, the graft-vs-host reaction, macrophage function, ...1975167880
biochemical characteristics of activated macrophages. 1975169721
regulation of the t-cell response to ectromelia virus infection. i. feedback suppression by effector t cells.spleen cells and serum from mice immunized with ectromelia virus suppressed the immune response to infectious virus when transferred intravenously into recipient mice given an immunizing virus dose. the suppression was reflected in decreased cytotoxic t-cell activity directed against h-2 compatible virus-infected target cells in the spleens of recipients. suppression was observed when immune cells or serum were transferred 1-2 h or 1 day after immunization of recipients, but not 2 days after, an ...1976175126
[meningo-encephalic complications caused by rare microorganisms in renal transplanted patients: cryptococcosis and listeriosis with favourable course]. 1976183277
antibodies to bacterial and tumor-derived antigens in sera from normal guinea pigs.antibodies that react with radiolabeled antigens derived from guinea pig line-10 tumor cells and mycobacterium bovis (bcg) were detected in sera from normal tumor-free strain-2 guinea pigs (ngps). binding by ngps to the two antigens was inhibited by extracts of either line-10 cells or bcg. binding by ngps to the line-10 antigen was inhibited by a number of other bacterial extracts. ngps was tested after absorption with a variety of cells including line-10, line-1, normal guinea pig spleen, norma ...1977197169
marrow-dependent cell function in early stages of infection with listeria monocytogenes. 1977198147
[cellular immunity in two experimental infections : listeriosis and ectromelia. experimental approach and recent developments (author's transl)]. 1977199880
[neuro-meningeal listerioses in adults. value of blood culture]. 1977204037
[influence of killed bordetella pertussis cells on the resistance against infection with listeria monocytogenes (author's transl)].the influence of killed bordetella pertussis cells (b.p.) on the cell-mediated resistance of mice against infection with virulent germs of listeria monocytogenes has been studied. resistance of mice was decreased, when 3 x 10(9) b.p. were injected 1 day before, simultaneously with or 1 day after infection, resulting in augmented amounts of viable listeriae recovered from the spleens 3 days after infection (figure 1). the ld50 was strongly reduced (table 1). transfer of immune spleen cells to rec ...1978207050
activation of reticuloendothelial cells following infection with murine cytomegalovirus.macrophage and reticuloendothelial system function was investigated in adult, female c3h mice during the course of a nonlethal infection with murine cytomegalovirus (mcmv). peritoneal macrophages harvested from mice infected three to 21 days previously were tumoricidal in vitro for a syngeneic mammary tumor cell line and showed antiviral activity by suppressing replication of vaccinia virus in a fibroblast monolayer. in addition, macrophages harvested from animals on days 7 and 14 after mcmv inf ...1979221597
in vitro acquisition of resistance against herpes simplex virus by permissive murine macrophages. 1979222234
[listeriosis : evaluation of twenty years of inquires at rouen (france) (author's transl)].the laboratory of bacteriology of the chu of rouen has isolated in twenty years 297 strains of listeria monocytogenes which are corresponding to 249 cases, 48 new-borns being infected by the same germ as their mother. the listeriosis frequency is increasing ; the disease is recurrent, with a periodicity of four years, but the number of the cases which are observed every year is larger than that which has been observed four years before. the disease seems to affect mainly the women ; in reality, ...1979224504
immunopotentiation and anabolism induced by sodium diethyldithiocarbamate.sodium diethyldithiocarbamate, dtc, enhances over a large range of doses macrophage listericidal capacity and t cell activities in terms of increased igg-antibody forming spleen cells and delayed hypersensitivity levels. such immunopotentiation is not associated with splenomegalia or increase in lymphocyte counts. immunopotentiation requires a preexisting link between carbon disulfide and diethylamine, since both moieties were inactive if administered alone or on separate body sites. dtc demonst ...1979233312
[determination of umbilical cord blood ig and its correlation with prenatal infections (author's transl)].igg, igm and iga were measured in 120 funicular blood samples. at the same time, these determinations were assayed in the mothers. in the serum samples of the newborn, iga and igm were found to have levels over 20 mg/100 ml. antibodies against rubella virus, cytomegalus virus, listeria monocytogenes and toxoplasma gondii were measured in order to investigate a possible intrauterine infection. all ig determinations were performed through the radial immunodiffusion method.1979233390
the mediator of cellular immunity. viii. effect of mitomycin c on specifically sensitized lymphocytes. 1975233966
[changes in the antibacterial effects of organs and tissues of ornithodoros papillipes birula ticks]. 1975234572
tularaemia in the rat. i. the cellular basis on host resistance to infection.rats infected with the live vaccine strain (lvs) of francisella tularensis develop in vivo and in vitro evidence of cellular hypersensitivity and a concomitant state of cellular resistance to infection. they key role of sensitized lymphocytes in cellular resistance was domonstrated in transfer experiments. using this technique, it was shown that thoracic duct lymphocytes from francisella immune donors conferred specific antimicrobial resistance on normal recipients, whereas antiserum afforded no ...1975236983
the mediator of cellular immunity. x. interaction of macrophages and specifically sensitized lymphocytes. 1975237635
activation of alveolar macrophages after lower respiratory tract infection.alveolar macrophage function has been studied in relation to bacterial infection of the lower respiratory tract. first, lrt macrophages were examined after exposure of rabbits to listeria monocytogenes aerosols. macrophages obtained from the lrt of animals 10 to 48 days after infection were activated, as evidenced by greater adherence to culture dishes and increased ability to ingest and kill both the original infecting organism and unrelated organisms, when compared to normal alveolar macrophag ...1975239059
evaluation of bacteriological transport systems.seven commercially manufactured bacteriological transport systems, including culturette, trans-cul (with stuart and amies), handiswab, securline (with amies and amies without charcoal) and culture caddy, were evaluated to determine whether these systems were capable of maintaining the viability and constant numbers of mixtures of hardy, fastidious and anaerobic organisms over 72 hours at 25c and 4c. the results of the study indicated that if specimens are maintained in transport systems at 25c t ...1975239597
comparative inhibitory activity of bl-s640 and two other cephalosporins.in vitro antibacterial activity of bl-s640 was compared to that of cephalothin and cephalexin against gram-negative and gram-positive bacteria isolated from clinical specimens. bl-s640 demonstrated the best activity on nearly all microbial species studied, except for haemophilus influenzae and diplococcus pneumoniae against which cephalothin was slightly more active.1975239917
[3 cases of neonatal meningitis caused by listeria monocytogenes type 4]. 1979262255
a case of listeriosis in pregnancy with fetal survival.listeriosis during pregnancy is generally considered to result in an intrauterine infection which affects the fetus before birth or in the perinatal period. a case of listeriosis in a 38-yr-old diabetic woman with an influenza-like disease in her 32nd wk of pregnancy is presented. two successive blood cultures were positive for listeria monocytogenes type 4b and her serum showed a rising titer for agglutinins to this organism. after antibiotic treatment of the patient she gave birth to a healthy ...1978264070
activation of reticuloendothelial system macrophages and enhancement of host resistance to a transplantable osteogenic sarcoma in mice by an extract of brucella abortus.an aqueous-ether extract of brucella abortus, bru-pel, enhanced resistance of mice to a transplantable osteogenic sarcoma (ogs). the results presented in this report suggest that bru-pel is an effective immunomodulator and that one mechanism through which it enhances host resistance is activation of phagocytic cells of the reticuloendothelial system. peritoneal macrophages from mice inoculated with bru-pel 14 days previously were cytotoxic for ogs cells in vitro, limited the multiplication of va ...1978282007
listeria monocytogenes pericarditis and myocardial abscess. 1979286406
cellular mechanisms in the protection against infection by listeria monocytogenes in mice.listeria monocytogenes, in doses of 2-0 x 10(3) to 3-0 x 10(3) viable organisms, was injected into athymic nude mice, irradiated mice and mice treated with reticuloendothelial system-blocking agents. viable counts on liver and spleen homogenates were made at intervals after infection. in both nude mice (nu/nu) and normal littermates (nu/+) of balb/c background, the bacteria grew rapidly for 24 h but increased only slowly thereafter, to reach a plateau of about 10(5) per organ at 72 h. in nu/+ mi ...1977302322
listeria monocytogenes endophthalmitis.a 62-year-old white man developed an acute anterior chamber inflammation in his left eye. listeria monocytogenes was cultured from the vitreous aspirate. there was no evidence for ocular trauma or distant site of infection from which hematogenous spread of the organism occurred. no underlying state of immunocompromise was demonstrated. the endophthalmitis responded well to therapy.1977302649
resistance and susceptibility of mice to bacterial infection: genetics of listeriosis.a survey of various strains of mice showed distinct differences in resistance or susceptibility to listeria monocytogenes. c57b1, related sublines, nzb, and sjl were resistant to listeria, whereas balb/c, cba, a, dba/1, c3h, lp.riii, 129, and wb were susceptible. the gene(s) responsible for resistance and susceptibility to listeria were studied in detail. c57bl6/6, b10.d2, and b10.a mice were 100 times more resistant than were balb/c, cba, and a. resistance of the (c57b1/6 x balb/c)f1 was interm ...1978305895
transfer of immunity against listeria monocytogenes by t cells purified by a positive selection technique.affinity columns prepared with rabbit antibody to the f(ab')(2) fragment of rat immunoglobulin were used to separate rat thoracic duct lymphocytes into sub-populations that differ with respect to the density of their surface membrane immunoglobulin. using this technique, it was shown that lymphocytes in the dna synthetic (s) phase of the mitotic cycle are added in increased number to the lymph of rats infected with listeria monocytogenes. the great majority of these s-phase cells lacked a high d ...1978310423
role of complement in the expression of delayed-type hypersensitivity in rats: studies with cobra venom factor.the hypothesis was tested that delayed-type hypersensitivity (dth) to the complement-activating bacterium listeria monocytogenes is initiated by complement-derived mediators that attract sensitized lymphocytes to reaction sites. to this end dth and acquired resistance to l. monocytogenes were measured in rats injected with cobra venom factor, a potent inactivator of c3. treatment with cobra venom factor reduced the hemolytic power of serum to less than 0.5% of the control value. such decomplemen ...1979313366
effects of cannabinoids on host resistance to listeria monocytogenes and herpes simplex virus.previous investigations from our laboratories have demonstrated that cannabinoids possess immunosuppressive properties. the present studies were designed to determine whether these agents decrease host resistance to infections with listeria monocytogenes and herpes simplex virus type 2. host resistance was measured by changes in the 50% lethal dose of the pathogen in cannabinoid-treated and control mice. the effect of cannabinoids on resistance to l. monocytogens was dose dependent. delta-9-tetr ...1979313368
inhibition of host resistance by nutritional hypercholesteremia.previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ...1979317596
antimicrobial spectrum, pharmacology and therapeutic use of antibiotics. part 2: penicillins.the mechanism of action, resistance, antibacterial spectrum, clinical pharmacology, adverse effects, and therapeutic and prophylactic use of penicillins are reviewed. the choice of a penicillin is discussed. the only indication for the penicillinase-resistant penicillins is the suspected or demonstrated presence of staphylococcus aureus. there are no important differences in therapeutic effect among oxacillin, cloxacillin, dicloxacillin or flucloxacillin by the oral route, or among oxacillin, di ...1977318800
infection in infants and children.infection with listeria monocytogenes is demonstrated over a 141/2 year period in 24 newborns, three infants 1 to 2 months of age, and two children. comparison of the 22 cases of listeria meningitis in newborns with 118 cases of neonatal meningitis due to other bacteria indicates a later onset of symptoms in cases of listeria meningitis with a more favorable outcome than with most other agents. treatment with ampicillin sodium appears effective. monocytic cell increases in peripheral blood or cs ...1977322473
corynebacterium equi infection complicating neoplastic disease.corynebacterium equi, a soil-residing diphtheroid pathogenic in horses, swine and cows, caused pulmonary infection with bacteremia in two patients with lymphomas. both patients were being treated with immunosuppressive therapy, as were the patients in three previously reported human cases. unless certain characteristics of these organisms are recognized, they may be regarded as normal flora or contaminating diphtheroids. they could also be mistaken for other gram-positive rods, such as bacillus ...1977326031
listeria infection in transplant patients. five cases and a review of the literature.we report five cases of listeria monocytogenes infection in renal transplant patients at the university of minnesota and compare them to 15 additional patients reported on in the united states literature. all patients were noted to have fever, malaise, and nonspecific symptoms of infection. there were no consistent diagnostic laboratory findings except for positive bacteriologic studies. successful treatment consisted of intravenous penicillin g potassium in most cases (ampicillin sodium was req ...1978339878
qualitative study of paradoxical zone phenomenon of penicillins against 17 bacterial species of clinical importance.using a triple agar layer technique and enzymatic inactivation of penicillin, the occurrence of a paradoxical zone phenomenon (illustrated by a typical 'target' image around the reservoir of antibiotic) was determined for several bacterial species specially chosen with regards to their taxonomic position, clinical importance and penicillin susceptibility. among gram-positive bacteria, a paradoxical zone was obtained for approximately 43% of the strains studied here (all 10 strains of staphylococ ...1978340171
nonspecific immunostimulant activities of synthetic trehalose-6,6'-diesters (lower homologs of cord factor).mycobacterial cord factors (6,6'-diesters of trehalose with mycolic acids ranging from c80 to c90) have been shown to protect mice effectively against infection with klebsiella pneumoniae or with listeria monocytogenes. our present findings indicate that the low-molecular-weight cord factor of corynebacterium diphtheriae (with corynomycolic acids ranging from c28 pto c36) is equally active. moreover, its synthetic analog (with synthetic c32 mycolic acid) has the same activity. two lower syntheti ...1978352926
specific and nonspecific resistance in mice immunized with irradiated myobacterium leprae.following subcutaneous inoculation of irradiated mycobacterium leprae (i-ml) into the left hind footpad of mice, there was increased resistance to listeria monocytogenes, indicative of macrophage activation, at the immunization site. in spite of the high level of localized macrophage activation which was proportioned to the immunizing dose of i-ml, no such activity could be demonstrated systemically in these mice, as evidenced by the absence of increased resistance to an intravenous challenge wi ...1978352954
chorio-meningo-encephalitis due to listeria monocytogenes after renal transplantation.a 35-year-old man, who underwent renal transplantation, died of meningo-encephalitis with symptoms of meningitis for only 8 days. the autopsy revealed marked chorio-meningo-encephalitis caused by listeria monocytogenes. this report on listeriosis in renal transplant patients is the second in our country, where adult cases of listeriosis are rare. recent knowledge about listeriosis in renal transplants is reviewed and discussed.1978362022
listeria monocytogenes: brain abscess or meningoencephalitis?a brain abscess caused by listeria monocytogenes developed in an immunosuppressed renal transplant patient. meningitis and meningoencephalitis from this organism were encountered in three other renal transplant recipients at this medical center during the past 4 years. focal neurologic deficits occurred in patients with either listeria abscess or meningoencephalitis. computerized tomography was a rapid aid to the diagnosis of abscess. immunosuppression has increased the incidence of central nerv ...1979370686
the variable response of bacteria to excess ferric iron in host tissues.the enhancement by exogenous ferric iron, both systemic and local, of the infectivity of 120 strains of bacteria, representing 17 genera, was measured in the skin of guinea-pigs. systemic iron enhanced only 23% of 115 strains, and local iron 49% of 71 strains. systemic iron, by an apparently anti-inflammatory action, depressed the size of lesions produced by 27 of the non-enhanced strains from nine of the genera tested. for most strains, the degree of enhancement was small, ranging from 2- to 8- ...1979372534
hexachlorobenzene-induced stimulation of the humoral immune response in rats.rats were fed diets containing 0, 500, 1000, and 2000 mg hcb/kg during a 3-week period. marked weight increases of spleen, popliteal and mesenteric lymph nodes and of the liver were found. histologically, the white pulp in the spleen was enlarged because of an increase in size of marginal zones and follicles. in addition, there was an increase of extramedullary hemopoiesis. in the lymph nodes, the number of high endothelial venules was increased at all dose levels. the number of neutrophils, bas ...1979378061
effects of bcg infection on the susceptibility of mouse macrophages to endotoxin.mice infected intravenously with mycobacterium bovis (bcg) are 100 to 1,000 times more sensitive to the lethal effects of bacterial lipopolysaccharides (lps). since bcg infection results in macrophage activation and lps may cause pathophysiological effects through interaction with this cell type, it was of interest to determine whether macrophages from bcg-infected animals were more susceptible to the toxic effects of lps in vitro. when lps-susceptible, c57bl/6 mice were infected with bcg, a sig ...1979378847
[inflammation and host resistance against bacteria. i.--increased resistance against listeria monocytogenes and salmonella typhimurium in mice, following their treatment with bradykinin, kallidin and methionyl-lysyl-bradykinin (author's transl)].mice pretreated with kinins are more resistant to a lethal challenge of listeria monocytogenes. the multiplication of listeria is decreased in the liver and spleen and the blood clearance of salmonella typhi-murium is increased.1979393161
indirect sandwich enzyme-linked immunosorbent assay for rapid detection of haemophilus influenzae type b infection.we report the development and testing of an enzyme-linked immunosorbent assay with excellent sensitivity for the detection of haemophilus influenzae type b (hi(b)) antigen in clinical specimens from patients with hi(b) meningitis. the assay, an indirect sandwich technique, uses polystyrene balls as a solid phase and an alkaline phosphatase-labeled goat anti-rabbit globulin conjugate. specimens are incubated with polystyrene balls armed with burro anti-hi(b) antiserum, and recognition antibody is ...1979393714
effect of sensitization with propionibacterium acnes on the growth of listeria monocytogenes and treponema pallidum in rabbits.sensitization of rabbits with propionibacterium acnes, a nonspecific stimulant of the reticuloendothelial system, was investigated as a means of enhancing resistance to treponema pallidum. a single i.v. dose of p. acnes given 3 or 7 days before challenge with listeria monocytogenes was capable of suppressing the growth of the heterologous organism, whereas a single i.v. dose 24 hr or 14 days before challenge was not. reactivation via i.v. elicitation with p. acnes 14 days after sensitization (1 ...1977401511
effect of amniotic fluid on bacterial growth.the bacteriostatic effect of amniotic fluid was studied using four pathogenic organisms which are encountered in the perinatal period, e. coli, s. aureus, l. monocytogenes, and group b beta hemolytic streptococci. amniotic fluid inhibited the growth of all four organisms, with a wide degree of individual variation among specimens. the greatest degree of inhibition was noted for l. monocytogenes and the least for e. coli. the time in gestation in which the amniotic fluid sample was obtained did n ...1977401535
destruction of experimental malignant melanoma by mediators of cellular immunity.listeria monocytogenes (lm) in admixture with b-16 melanoma suppresses local tumor development in syngeneic c57bl/6 mice. in vitro, lm-immune peritoneal and splenic cells are cytotoxic to b-16. induction of cell-mediated immunity to lm antigens are required for the killing effect, since effector cells from lm-"immune" athymic nude mice are unable to kill tumor cells in vitro. further, elimination of macrophages by a specific antiserum plus complement abrogates the cytotoxic effect of peritoneal ...1977401681
activation of guinea pig macrophages by q fever rickettsiae. 1977401688
synergism of penicillin and gentamicin against listeria monocytogenes in ex vivo hemodialysis culture.a new technique of ex vivo hemodialysis culture was used to study the effects against listeria monocytogenes of penicillin g and gentamicin administered intra-muscular, singly and in combination, in the goat. bactericidal synergism of the combination was detected despite rapidly diminishing concentrations of the drugs in the blood plasma and dialysate.1977401852
t-cell-mediated concomitant immunity to syngeneic tumors. i. activated macrophages as the expressors of nonspecific immunity to unrelated tumors and bacterial parasites.progressive growth of the sa1 sarcoma was shown to result in the generation of a state of concomitant resistance to growth of a second implant of the same tumor. the responding lymph nodes of concomitantly immune mice were shown to contain theta-positive t cells that could specifically neutralize the growth of tumor cells in a normal test recipient. nevertheless, the concomitantly immune host itself was capable to a limited extent of suppressing the growth of unrelated tumors. the generation of ...1977401860
requirement for magnesium influx in activation of alveolar macrophages mediated by ionophore a23187. 1977401955
infectious keratoconjunctivitis in cattle associated with listeria monocytocytogenes. 1977402729
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