Publications

tert-butyl hydroperoxide-induced radical production in rat liver mitochondria.	when rat liver mitochondria are treated with tert-butyl hydroperoxide (tbhp) in the presence of the spin trap 5,5-dimethyl-1-pyrroline n-oxide (dmpo), electron paramagnetic resonance (epr) signals are detected attributable to spin adducts resulting from the trapping of methyl, tert-butoxyl, and tert-butylperoxyl radicals. the addition of respiratory substrate results in a 3- to 7.5-fold increase in the signal intensity of the dmpo/methyl adduct, no change in the signal intensity of the dmpo/tert ...	1992	1317326
on the mechanism of action of picrotoxin on gaba receptor channels in dissociated sympathetic neurones of the rat.	1. the mechanism of action of picrotoxin on gaba receptor channels in rat sympathetic neurones has been investigated with whole-cell clamp. in addition, the action of picrotoxin on single gaba channels has been examined in outside-out membrane patches from these cells. 2. picrotoxin, at concentrations which dramatically reduced the amplitude of whole-cell gaba currents, did not alter the spectral time constants or single-channel conductance estimated by analysis of gaba-activated current noise. ...	1992	1317428
concentrations of endothelial-cell-stimulating angiogenesis factor, a major component of human uterine angiogenesis factor, in human and bovine embryonic tissues and decidua.	embryonic development involves the establishment of new patterns of vascular growth in the fetus and within the lining of the womb. a factor, human uterine angiogenesis factor, has been purified from the decidua and stimulates the growth of blood vessels in collagen sponge implants and in the chick chorioallantoic membrane. evidence is presented that suggests that a major active component of human uterine angiogenesis factor is an activator of latent matrix metalloproteinases, of low m(r), calle ...	1992	1317450
[molecular bases of chronic granulomatous disease--analysis of the involvement of cytosol factors for nadph oxidase].	during the past 5 years, the discovery of cell-free superoxide generation system (bromberg y, pick e: cell immunol 88:213-221, 1984) has been revolutionized our understanding of phagocyte superoxide generation. using cell-free system, it was clarified that nadph oxidase for superoxide generation was comprised of components present in both the plasma membrane as well as in the cytosol. this oxidase could be kept inactive by keeping its components separated from each other within the cell and then ...	2005	1317471
reaction mechanism of glutamate racemase, a pyridoxal phosphate-independent amino acid racemase.	glutamate racemase of pediococcus pentosaceus contained no cofactor, and was completely inactivated by a thiol reagent. the role of a cysteine residue in the enzyme reaction was studied by chemical modification. the modification of this cysteine residue resulted in a concomitant loss of activity. dl-glutamate protected the enzyme from inactivation. the inactivated enzyme was reactivated by addition of dithiothreitol. the racemization in 2h2o showed an overshoot in the optical rotation of glutama ...	1992	1358877
inhibition of trypsin by t-butyloxycarbonyl-alpha-aza-(4-aminophenyl)alanine phenyl ester.	t-butyloxycarbonyl-alpha-aza-(4-aminophenyl)alanine phenyl ester (iii: r = nh2) has been synthesized. the rate of inhibition of trypsin (ec 3.4.21.4) by this compound (due to acylation followed by slower deacylation) shows a marked ph maximum at approximately 6. the shape of the ph-rate curve is discussed in terms of (i) the normal ph-activity curve of trypsin reacting with a charged substrate, i.e. the protonated form of the amino compound, (ii) the deprotonation of the 4-amino group with pka 4 ...	2006	1367228
promoting sexual health.		2006	1392896
effects of magnesium on cocaine-reinforced responding in mice, rats and squirrel monkeys.		1992	1435977
unilateral headache with features of hemicrania continua and cervicogenic headache--a case report.	a case is presented which has features of cervicogenic headache and of hemicrania continua. a sudden maneuver of the neck and later a greater occipital nerve block, both resulted in relief of the pain. a cervical cause is suggested.	2006	1446991
[the comprehensive diagnosis and treatment of lymphosarcoma of the pharynx].	modern methods (intrascopic and other instrumental) were used to increase the diagnostic efficiency and extension of the tumour process in 22 patients with lymphosarcoma of the pharynx. optimal treatment efficacy is achieved in lymphosarcoma of the pharynx by combined use of surgical, radiation (non-traditional course) treatment as well as chemotherapy which is used at early stages as an adjunctive method.	2006	1448998
pyomyositis and cryptococcal sepsis in an hiv-infected patient with severe granulocyte defect.		1992	1472345
transforming growth factor beta and basic fibroblast growth factor synergistically promote early bovine embryo development during the fourth cell cycle.	developmentally competent bovine blastocysts were produced by adding transforming growth factor beta (tgf beta) and basic fibroblast growth factor (bfgf) to serum-free cultures of in vitro produced, 2-cell bovine embryos. the effects of tgf beta were evaluated because this growth factor signals synthesis and secretion of the extracellular matrix component fibronectin and its receptor. previous investigations have demonstrated that fibronectin promotes early bovine embryo development in vitro. th ...	1992	1472373
capture, mutate, quantitate: variations of a central pcr scheme.		2006	1472383
the scope of professional practice.		2006	1483017
the effects of na(+)-k(+)-cl- co-transport and cl(-)-hco3-exchange blockade on the membrane potential and intracellular chloride levels of rat arterial smooth muscle, in vitro.	membrane potential and intracellular chloride levels have been measured simultaneously in vascular smooth muscle from the femoral artery of the rat, in vitro, using double-barrelled chloride-sensitive microelectrodes. these values are compared in the presence and absence of bicarbonate, and inhibitors of cl(-)-hco3- exchange and na(+)-k(+)-cl- co-transport. both dids and bumetanide caused a hyperpolarization of membrane potential (em) and a fall in [cl-]i, in the presence of extracellular hco3-. ...	1992	1489543
cd45 isoform expression on human neonatal t cells: expression and turnover of cd45 isoforms on neonatal versus adult t cells after activation.	neonatal t cells are phenotypically similar to "naive" t cells from adult donors in the cd45 isoform expression. despite the phenotypic similarity, large differences were found between neonatal and adult t cells when t cells were activated. after activation with pha, adult cd45ra+ t cells began to express cd45ro and no loss of cd45ra expression had yet occurred at day 3 post-stimulation. three days after activation, cd45ra+ neonatal t cells also coexpressed cd45ro; however, in contrast to adult ...	1992	1534035
medical waste: science vs politics.		2006	1539964
intrauterine resuscitation in the severely distressed fetal dog.	severe fetal distress was produced in 16 fetal dogs by successive and/or prolonged occlusion of the maternal abdominal aorta in an acute surgical preparation, and was characterized in fetal arterial blood of 7.06 for ph, 10 mm hg for o2, 127 mm hg for co2, and fetal heart rate decelerations. five fetuses recovered spontaneously in utero and delivered normally; 3 needed maternal oxygenation before delivery; 3 suddenly died in utero; 5 fetuses were delivered while still alive in utero when the tph ...	1992	1563650
external cephalic version and daily post-versional maternal self-assessment of fetal presentation. a prospective study.	external cephalic version (ecv) using tocolysis is a widely recognized low-risk intervention in cases of breech presentation, particularly in areas where resources are scarce and the perinatal mortality is high in vaginal breech deliveries. in such a setting, pregnant women were trained to make regular self-assessments of the presenting fetal part after ecv in order to detect spontaneous reversions to breech presentation. it was found that such maternal involvement could significantly improve th ...	2006	1563651
occurrence of antinuclear antibodies in an unselected pregnancy population.	the occurrence of antinuclear antibodies (ana) in an unselected population of pregnant women was studied by an indirect immunofluorescence method. six women out of 116 were ana-positive (5.2%), 2 of them having a moderately high titre (1:160 and 1:320) and 1 complement-fixing ana. the antigenic specificity of ana was anti-single-stranded dna in 2 cases and rnaase-sensitive anti-extractable nuclear antigen in 1 case. two of the ana-positive women had pre-eclampsia laevis and 1 had a premature del ...	2006	1563653
pharmacokinetic interaction between 1,3-butadiene and styrene in sprague-dawley rats.	gas uptake studies were carried out to evaluate kinetic interactions between 1,3-butadiene and styrene in sprague-dawley rats. the animals were co-exposed by inhalation to a mixture of 1,3-butadiene between 20 and 6000 ppm (v/v) and styrene between 0 and 500 ppm. the data demonstrate that metabolism of 1,3-butadiene was partially inhibited by styrene. the inhibition was competitive at atmospheric concentrations of styrene up to 90 ppm. higher concentrations of styrene resulted in a small additio ...	1992	1610292
headspace flavour compounds produced by yeasts and lactobacilli during fermentation of preferments and bread doughs.	production of volatile flavour compounds during fermentation with pure cultures of saccharomyces cerevisiae and candida guilliermondii, lactobacillus brevis and lactobacillus plantarum have been investigated, using wheat doughs and several preferements as substrates. for yeast, preferments consisted of 10% (w/v) glucose, maltose and sucrose solutions, whereas for lactobacilli they consisted of supplemented and unsupplemented (3% and 10% (w/v)) glucose solutions, and a 10% (w/v) wheat flour slurr ...	1992	1622751
soft tissue sarcomas: experience with intraoperative brachytherapy in the conservative management.	forty-eight patients with soft tissue sarcomas were treated with iridium implant after wide local excision between 1980 and 1990 at our institution. external irradiation was also given postoperatively in 33 patients with initially resectable tumours (treatment a) and preoperatively in 3 with initially unresectable tumours (treatment c); brachytherapy was the only treatment in 12 patients presenting small superficial tumours or recurring after previous irradiation (treatment b). median follow up ...	2006	1622870
spatial and temporal regulations in helicoidal extracellular matrices: comparison between plant and animal systems.	this paper proposes an overview of the last few years' investigations regarding the helicoid formation in extracellular matrices (ecms). despite the architectural polymorphism displayed among the layered ecm throughout the living kingdom, helicoidal structures are often described in ecms and appear as an optimal mechanical device. helicoids correspond to complex two-phases composites, formation and regulation of which are still a source of debate. taking the time-event into consideration, it is ...	2006	1636171
treatment of multiple intracranial aneurysms in the anterior circulation--case report.	a 69-year-old female underwent surgery for subarachnoid hemorrhage due to a ruptured intracranial aneurysm. nine additional aneurysms were found. four of the latter nine aneurysms were clipped in a second operation, and two were wrapped.	2006	1694273
conduction velocity distribution of afferent fibers innervating the rat urinary bladder.	the conduction velocities of individual afferent fibers innervating the rat urinary bladder were determined by the antidromic stimulation of dorsal roots while recording from bladder postganglionic nerves. conduction velocities ranged from 0.5 to 21.0 m/s; 70% of the velocities were less than 2.5 m/s. the distribution within the dorsal roots was ipsilateral with 84% in l6 and 16% in s1. neuroanatomical tracing with horseradish peroxidase applied to individual bladder postganglionic nerves result ...	1990	1698508
septicaemia caused by pediococcus pentosaceus: a new opportunistic pathogen.	a case of septicaemia caused by pediococcus pentosaceus is described. the role played by pediococci, and other vancomycin-resistant gram-positive cocci, in disease states is examined. we suggest that in immunocompromised patients these organisms act as opportunist pathogens. this would appear to be the first reported case of p. pentosaceus septicaemia.	1991	1753117
recovery of vancomycin-resistant gram-positive cocci from pediatric liver transplant recipients.	between november 1988 and october 1989, 49 first-time pediatric liver transplant recipients at the children's hospital of pittsburgh were prospectively monitored for the presence of stool colonization and the development of disease caused by vancomycin-resistant gram-positive cocci (vrgpc). quantitative stool culturing was done on a weekly basis, and cultures were planted onto a selective medium for vrgpc. isolates for which the mic was greater than or equal to 8 were considered resistant to van ...	1991	1774255
bacteriocin-mediated inhibition of clostridium botulinum spores by lactic acid bacteria at refrigeration and abuse temperatures.	the bacteriocinogenicity of lactococcus lactis atcc 11454, pediococcus pentosaceus atcc 43200, p. pentosaceus atcc 43201, lactobacillus plantarum bn, l. plantarum lb592, l. plantarum lb75, and lactobacillus acidophilus n2 against clostridium botulinum spores at 4, 10, 15, and 35 degrees c was investigated by modified deferred and simultaneous antagonism methods. all the strains, except l. acidophilus n2, produced inhibition zones on lawns of c. botulinum spores at 30 degrees c. l. plantarum bn, ...	1991	1785919
endotoxin induces eosinophil accumulation in the rat pleural cavity.	changes in eosinophil counts after intrathoracic (it) injection of endotoxin (lps) were investigated in wistar rats (150-180 g). increasing doses of endotoxin (62.5-500 ng/cavity) induced a dose-dependent increase in the number of eosinophils recovered from the rat pleural cavity 24 h later. the eosinophilia was apparent within 24 h, peaked within 48 h (from 0.76 +/- 0.12 to 3.68 +/- 0.51 eosinophils x 10(6)/cavity, p less than 0.001) and returned to basal levels 120 h after the it injection of ...	1991	1797292
endotoxin induces eosinophil accumulation in the rat pleural cavity.	changes in eosinophil counts after intrathoracic (it) injection of endotoxin (lps) were investigated in wistar rats (150-180 g). increasing doses of endotoxin (62.5-500 ng/cavity) induced a dose-dependent increase in the number of eosinophils recovered from the rat pleural cavity 24 h later. the eosinophilia was apparent within 24 h, peaked within 48 h (from 0.76 +/- 0.12 to 3.68 +/- 0.51 eosinophils x 10(6)/cavity, p less than 0.001) and returned to basal levels 120 h after the it injection of ...	1991	1797292
effects of the glycine prodrug milacemide (2-n-pentylaminoacetamide) on catecholamine secretion from isolated adrenal medulla chromaffin cells.	1. milacemide (2-n-pentylaminoacetamide) is a glycine prodrug which readily crosses the blood brain barrier and increases brain glycine and glycineamide. in vitro and in vivo studies, with numerous tissues, including adrenal chromaffin cells, have clearly shown that the formation of the latter metabolites is exclusively mediated by monoamine oxidase b for which milacemide is a substrate. 2. milacemide, glycineamide and glycine caused a time- and dose-dependent release of catecholamines from bovi ...	1991	1797336
effects of the glycine prodrug milacemide (2-n-pentylaminoacetamide) on catecholamine secretion from isolated adrenal medulla chromaffin cells.	1. milacemide (2-n-pentylaminoacetamide) is a glycine prodrug which readily crosses the blood brain barrier and increases brain glycine and glycineamide. in vitro and in vivo studies, with numerous tissues, including adrenal chromaffin cells, have clearly shown that the formation of the latter metabolites is exclusively mediated by monoamine oxidase b for which milacemide is a substrate. 2. milacemide, glycineamide and glycine caused a time- and dose-dependent release of catecholamines from bovi ...	1991	1797336
intravenous hypertonic saline induces fos immunoreactivity in neurons throughout the lamina terminalis.	expression of fos, the protein product of c-fos, was studied immunohistochemically in the forebrain of rats infused intravenously with hypertonic solutions. intravenous 1.5 or 0.75 mol/l nacl or 1.2 mol/l sucrose in 0.15 mol/l nacl, but not isotonic 0.15 mol/l nacl, caused increased fos expression in the hypothalamic paraventricular and supraoptic nuclei and throughout the lamina terminalis (organum vasculosum laminae terminalis, median preoptic nucleus and subfornical organ). these results show ...	1991	1797341
intravenous hypertonic saline induces fos immunoreactivity in neurons throughout the lamina terminalis.	expression of fos, the protein product of c-fos, was studied immunohistochemically in the forebrain of rats infused intravenously with hypertonic solutions. intravenous 1.5 or 0.75 mol/l nacl or 1.2 mol/l sucrose in 0.15 mol/l nacl, but not isotonic 0.15 mol/l nacl, caused increased fos expression in the hypothalamic paraventricular and supraoptic nuclei and throughout the lamina terminalis (organum vasculosum laminae terminalis, median preoptic nucleus and subfornical organ). these results show ...	1991	1797341
comparative anatomical distribution of 5-ht1a receptor mrna and 5-ht1a binding in rat brain--a combined in situ hybridisation/in vitro receptor autoradiographic study.	the present study examined the comparative distribution of 5-ht1a receptor mrna and 5-ht1a receptors in rat brain using a combination of in situ hybridisation histochemistry and in vitro receptor autoradiography. 5-ht1a mrna was visualized using a 910 bp crna probe synthesised from a bali-pvuii fragment of the rat 5-ht1a reetor gene, while 5-ht1a receptors were labelled with the 5-ht1a-selective ligand 8-oh-dpat. in general terms, there was a complementary distribution of cells expressing 5-ht1a ...	1991	1797349
comparative anatomical distribution of 5-ht1a receptor mrna and 5-ht1a binding in rat brain--a combined in situ hybridisation/in vitro receptor autoradiographic study.	the present study examined the comparative distribution of 5-ht1a receptor mrna and 5-ht1a receptors in rat brain using a combination of in situ hybridisation histochemistry and in vitro receptor autoradiography. 5-ht1a mrna was visualized using a 910 bp crna probe synthesised from a bali-pvuii fragment of the rat 5-ht1a reetor gene, while 5-ht1a receptors were labelled with the 5-ht1a-selective ligand 8-oh-dpat. in general terms, there was a complementary distribution of cells expressing 5-ht1a ...	1991	1797349
thoracic actinomycosis--review of 9 cases.	nine cases of thoracic actinomycosis treated in the period from 1976 to 1990 were reviewed. among them, 4 cases were children. the clinical symptoms and laboratory examinations were non-specific. chest roentgenographic manifestations including nodular (3 cases), infiltrations (4 cases), and infiltrations with pleural changes (2 cases) were also non-specific. chest wall masses were noted in four patients. there were no cases correctly diagnosed on admission. the diagnosis of thoracic actinomycosi ...	2006	1797368
thoracic actinomycosis--review of 9 cases.	nine cases of thoracic actinomycosis treated in the period from 1976 to 1990 were reviewed. among them, 4 cases were children. the clinical symptoms and laboratory examinations were non-specific. chest roentgenographic manifestations including nodular (3 cases), infiltrations (4 cases), and infiltrations with pleural changes (2 cases) were also non-specific. chest wall masses were noted in four patients. there were no cases correctly diagnosed on admission. the diagnosis of thoracic actinomycosi ...	2006	1797368
moderate and mild mental retardation in the martin-bell syndrome.	a survey of children attending schools for the moderately or the mildly mentally handicapped has shown that two out of 25 boys and two out of 22 girls with idiopathic moderate mental retardation had the martin-bell syndrome, while none of 75 boys and one out of 51 girls with mild mental retardation were fraxa positive. consideration of these figures along with published studies suggests that 7% of moderate and 3.8% of mild idiopathic mental retardation in boys, and 2.5% of moderate and 3.3% of m ...	2006	1800751
moderate and mild mental retardation in the martin-bell syndrome.	a survey of children attending schools for the moderately or the mildly mentally handicapped has shown that two out of 25 boys and two out of 22 girls with idiopathic moderate mental retardation had the martin-bell syndrome, while none of 75 boys and one out of 51 girls with mild mental retardation were fraxa positive. consideration of these figures along with published studies suggests that 7% of moderate and 3.8% of mild idiopathic mental retardation in boys, and 2.5% of moderate and 3.3% of m ...	2006	1800751
successful introduction of an intravenous line insertion team at a municipal hospital.	an intravenous line insertion and blood drawing team was introduced as a pilot project in a large municipal hospital in the new york city. the program successfully accomplished the goals of reducing house staff workload, improving house staff morale and patient care, and increasing available time for house staff education.	2006	1800767
successful introduction of an intravenous line insertion team at a municipal hospital.	an intravenous line insertion and blood drawing team was introduced as a pilot project in a large municipal hospital in the new york city. the program successfully accomplished the goals of reducing house staff workload, improving house staff morale and patient care, and increasing available time for house staff education.	2006	1800767
overproduction of glutamate racemase of pediococcus pentosaceus in escherichia coli clone cells and its purification.	we previously isolated a 6.0-kb dna fragment that specifies glutamate racemase activity from the chromosomal dna of pediococcus pentosaceus by digestion with hindiii (n. nakajima, k. tanizawa, h. tanaka, and k. soda, 1986), agric. biol. chem. 50, 2823-2830). we digested it further with ecori to obtain a fragment of 1.8 kb, which was blunt-ended and ligated into the smai site of vector plasmid pkk223-3. the recombinant plasmid showed a high glutamate racemase activity upon transformation of esche ...	1991	1821778
cost, controversy, crisis: low back pain and the health of the public.		2006	1828670
topical puva therapy for vitiligo.	vitiligo, a pigmentary disorder of the skin, causes the appearance of white patches which are profoundly devastating to the person afflicted with this disease. this article outlines the safe use of topical puva therapy in the office for treating those patients with less than 20% skin surface involvement. this treatment has a response rate of approximately 50%.	2006	1828681
topical puva therapy for vitiligo.	vitiligo, a pigmentary disorder of the skin, causes the appearance of white patches which are profoundly devastating to the person afflicted with this disease. this article outlines the safe use of topical puva therapy in the office for treating those patients with less than 20% skin surface involvement. this treatment has a response rate of approximately 50%.	2006	1828681
regulation and glucocorticoid-independent induction of lipocortin i in cultured astrocytes.	stimulation of prostaglandin (pg) release in rat astroglial cultures by various substances, including phorbol esters, melittin, or extracellular atp, has been reported recently. it is shown here that glucocorticoids (gcs) reduced both basal and stimulated pgd2 release. hydrocortisone, however, did not inhibit atp-, calcium ionophore a23187-, or tetradecanoyl phorbol acetate (tpa)-stimulated arachidonic acid release, and only tpa stimulations were affected by dexamethasone. gc-mediated inhibition ...	1991	1828830
[3h]mk-801 binding to n-methyl-d-aspartate receptors solubilized from rat brain: effects of glycine site ligands, polyamines, ifenprodil, and desipramine.	the n-methyl-d-aspartate (nmda) receptor is thought to contain several distinct binding sites that can regulate channel opening. in the present experiments, the effects of ligands for these sites have been examined on [3h]mk-801 binding to a soluble receptor preparation, which had been passed down a gel filtration column to reduce the levels of endogenous small-molecular-weight substances. glycine site agonists, partial agonists, and antagonists gave effects similar to those observed in membrane ...	1991	1828832
cyclophellitol: a naturally occurring mechanism-based inactivator of beta-glucosidases.	the natural product cyclophellitol, isolated from the culture filtrate of a mushroom, phellinus sp. is found to be a highly specific and effective irreversible inactivator of beta-glucosidases. it inactivates the beta-glucosidases from both almond emulsin and agrobacter sp. according to pseudo-first order kinetics with inactivation constants of ki = 0.34 mm, ki = 2.38 min-1, and ki = 0.055 mm, ki = 1.26 min-1 respectively. no reactivation of the inactivated enzyme is seen upon dialysis, thus pro ...	1991	1904221
the effect of pediococcus damnosus and pediococcus pentosaceus on the growth of pathogens in minced meat.	the antibacterial effects of one strain of pediococcus damnosus and two strains of pediococcus pentosacaeus against clostridium perfringens, listeria monocytogenes, salmonella infantis and yersinia enterocolitica were investigated. growth inhibition studies were conducted in juice from minced meat incubated at +6 degrees c and +15 degrees c for various periods after the inoculation with pediococci. inhibitory effects were seen for all bacteria tested.	1991	1907475
the occurrence and growth of microorganisms during the fermentation of fish sausage.	minced fish (mullet) sausage mixes containing added sugar, salt, nitrate, nitrite and spices were fermented (48 h, 30 degrees c) by indigenous flora or by a starter culture (pediococcus acidilactici) and the microbial ecology and behaviour of various bacteria was monitored. pediococcus pentosaceus and lactobacillus plantarum dominated the indigenous fermentation, achieving populations of 10(7)-10(8) cfu/g by 48 h, and decreasing the ph of the mix to 4.5-4.7. significant growth (10(5)-10(7) cfu/g ...	1991	1909546
new prosthetic venous collar anastomotic technique: combining the best of other procedures.		2007	1913097
acid and the pain of non-ulcer dyspepsia.		2007	1932675
[leukocyte and atherosclerosis].		2007	1947989
isolated significant left main coronary artery stenosis: angiographic, hemodynamic, and clinical findings in 16 patients.	among 21,545 adult patients who underwent consecutive coronary angiography, 16 (0.07%) were found during their coronary arteriography to have a significant isolated stenotic lesion (luminal diameter narrowing of 50% or more) located at the left main coronary artery. the remaining major epicardial coronary arteries and their branches were free of disease. a strong predilection for the isolated lesion to occur at the ostium of the left main artery was found (12 patients). the most common presentin ...	2007	1950993
the effect of prophylaxis with chloroquine and proguanil on delayed-type hypersensitivity and antibody production following vaccination with diphtheria, tetanus, polio, and pneumococcal vaccines.	in vitro studies have shown that anti-malarial drugs suppress immunity. in this study, the effects of chloroquine and proguanil (paludrine) on the cellular and humoral immune system were measured by two in vivo methods: 1) cell-mediated immunity (delayed cutaneous hypersensitivity) i.e., skin tests with seven delayed-type common antigens (multitest) and 2) humoral immunity by measurement of specific antibody response to vaccination. sixty healthy young individuals were randomized into four group ...	1991	1951872
use of dna probes in the study of silage colonization by lactobacillus and pediococcus strains.	a technique to monitor lactic acid bacteria inoculants in silage, based on specific dna probes, was developed and used to evaluate the colonization properties of two strains of lactobacillus plantarum and one strain of pediococcus pentosaceus which were used as maize silage inoculants in farm conditions. the results indicated that these three strains were able to dominate the natural microflora of the silage, representing more than the 95% of the bacterial biomass of the maize silage. these stud ...	1991	1960106
hospital outbreak of scabies stemming from two aids patients with norwegian scabies.		2007	1971073
violent trends.		2007	2034554
oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. role of scavenger receptor and endothelium-derived nitric oxide.	we studied the effects of low density lipoprotein (ldl) on endothelium function.	1991	2040054
no evidence for the enhanced production of insulin autoantibodies after confrontation with common viral antigens in insulin dependent diabetes mellitus.	the production of insulin autoantibodies (iaa) was studied after common viral infections in 12 children with type 1 diabetes mellitus and in their 18 healthy siblings. in addition, the production of iaa was measured after influenza vaccination with booster in 39 patients with type 1 diabetes mellitus and in 39 healthy controls. in 7 of the 12 diabetic children 13 viral infections were serologically confirmed. among the siblings 14 periods of infection were noted in 9 individuals. a significant r ...	2007	2074915
[fractures-dislocations of the shoulder in middle-aged and elderly patients].	114 patients with fracture dislocations of the proximal end of humerus have been treated and observed. 83 of them were subjected to conservative and 31--to surgical treatment. clinical, roentgenologic and radiologic evaluation of the immediate and long-term results allowed to formulate recommendations as to the selection of the treatment method of humerus fracture dislocations depending upon their type and general state of the patients.	2007	2074957
[familial juvenile nephronophthisis].		2007	2075033
[a case illustrating diagnostic difficulties in bronchiolo- alveolar cancer].		2007	2168044
[biochemistry of mitochondrial encephalomyopathy].		2007	2223265
[biochemistry of mitochondrial encephalomyopathy].		2007	2223265
mucinous ascites associated with rupture of benign ovarian teratoma. case report.		2007	2223689
mucinous ascites associated with rupture of benign ovarian teratoma. case report.		2007	2223689
probing the coenzyme specificity of glyceraldehyde-3-phosphate dehydrogenases by site-directed mutagenesis.	by combining our knowledge of the crystal structure of the glycolytic nad-dependent glyceraldehyde-3-phosphate dehydrogenase (gapdh) and the sequence of the photosynthetic nadp-dependent gapdh of the chloroplast, two particular amino acid residues were predicted as the principal determinants of differing coenzyme specificity. by use of site-directed mutagenesis, the amino acids leu 187 and pro 188 of gapdh from bacillus stearothermophilus have been replaced with ala 187 and ser 188, which occur ...	1990	2223764
probing the coenzyme specificity of glyceraldehyde-3-phosphate dehydrogenases by site-directed mutagenesis.	by combining our knowledge of the crystal structure of the glycolytic nad-dependent glyceraldehyde-3-phosphate dehydrogenase (gapdh) and the sequence of the photosynthetic nadp-dependent gapdh of the chloroplast, two particular amino acid residues were predicted as the principal determinants of differing coenzyme specificity. by use of site-directed mutagenesis, the amino acids leu 187 and pro 188 of gapdh from bacillus stearothermophilus have been replaced with ala 187 and ser 188, which occur ...	1990	2223764
desferrioxamine provocative test: methodology for estimating iron and total iron binding capacity.		2006	2242435
chlamydial igg and iga in serum and follicular fluid among patients undergoing in vitro fertilisation.	the point prevalence of igg and iga antibodies to chlamydia was analyzed in serum and follicular fluid in 63 patients undergoing in vitro fertilisation (ivf) in comparison to sera of 298 healthy women by the single serovar (l2) inclusion immunoperoxidase assay (ipa). the presence of specific igg and iga to chlamydia in follicular fluid was demonstrated. no statistical association was found between the presence of specific chlamydia igg and iga in serum and follicular fluid to oocyte fertilizatio ...	1990	2242796
[pregnancy and cystic fibrosis. a case history].	the authors report a case of pregnancy in a patient suffering from moderately severe cystic fibrosis (the syndrome consisted of diffused obstruction in respiratory function with a vital capacity of 79% and the lowered blood oxygen level with arterial blood gas estimations; oxygen saturation was 94%). the condition was marked by temporary worsening during the pregnancy in which infective bronchitis supervened). she also threatened to go into early labour and did in fact deliver at 36 1/2 weeks of ...	2007	2258595
cloning and sequence analysis of mink growth hormone cdna.	a cdna clone for mink growth hormone (gh) was isolated from a mink pituitary cdna library, employing a part of rat growth hormone cdna sequence as a probe. according to the nucleotide sequence, mature mink gh consists of 190 amino acids with a calculated molecular weight of 21,720. the amino acid sequence homology between the mature region of mink gh and those of pig gh, rat gh, bovine gh and human gh was 98.4%, 93.7%, 89.0% and 66.7%, respectively.	1990	2268323
the aps knee joint prosthesis. a review of 32 patients.	first clinical and radiographic results with a new knee joint prosthesis, implanted without cement, are reported and the characteristics of the implant (dowel fixation and special instrumentation) presented. the first series of 35 joints with a follow-up period of 1-3 years shows excellent results. radiographically, primary osseous integration cannot be positively identified in all cases, but it could be proved in most instances. cement-free implantation requires good preoperative bone quality a ...	2008	2271356
prolongation of anesthesia with xylazine, ketamine, and guaifenesin in horses: 64 cases (1986-1989).	on 74 occasions, 54 horses and 6 foals were anesthetized with xylazine and ketamine or xylazine, guaifenesin, and ketamine, with or without butorphanol. on 64 occasions, anesthesia was prolonged for up to 70 minutes (34 +/- 15 min) by administration of 1 to 9 supplemental iv injections of xylazine and ketamine at approximately a third the initial dosage. all horses except 5 were positioned in lateral recumbency, and oxygen was insufflated. in adult horses, the time from induction of anesthesia t ...	2008	2276967
aminooxy analogues of spermidine as inhibitors of spermine synthase and substrates of hepatic polyamine acetylating activity.	aminooxy analogues of spermidine, 1-aminooxy-3-n-[3-aminopropyl]- aminopropane (ap-apa) and n-[2-aminooxyethyl]-1,4-diaminobutane (aoe-pu), were tested as substrates or inhibitors of the enzymes involved in methionine and polyamine metabolism. both compounds were good competitive inhibitors and poor substrates of spermine synthase, good substrates of cytosolic polyamine acetyltransferase, inactivators of s-adenosylmethionine decarboxylase and inhibitors of ornithine decarboxylase. ap-apa and aoe ...	1990	2292587
mapping the effects of motor cortex stimulation on somatosensory relay neurons in the rat thalamus: direct responses and afferent modulation.	single unit recordings were used to map the spatial distribution of motor (mi) cortical influences on thalamic somatosensory relay nuclei in the rat. a total of 215 microelectrode penetrations were made to record single neurons in tracks through the medial and lateral ventroposterior (vpm and vpl), ventrolateral (vl), reticular (nrt), and posterior (po) thalamic nuclei. single units were classified according to their: 1) location within the nuclei, 2) receptive fields, and 3) response to standar ...	1990	2322860
mapping the effects of motor cortex stimulation on somatosensory relay neurons in the rat thalamus: direct responses and afferent modulation.	single unit recordings were used to map the spatial distribution of motor (mi) cortical influences on thalamic somatosensory relay nuclei in the rat. a total of 215 microelectrode penetrations were made to record single neurons in tracks through the medial and lateral ventroposterior (vpm and vpl), ventrolateral (vl), reticular (nrt), and posterior (po) thalamic nuclei. single units were classified according to their: 1) location within the nuclei, 2) receptive fields, and 3) response to standar ...	1990	2322860
adolescent medicine.		2008	2329647
bismuth subsalicylate in the prevention of colonization of infant mice with campylobacter jejuni.	infant mice were used for the evaluation of the efficacy of bismuth subsalicylate (bss) in the prevention of the growth of campylobacter jejuni in the intestine. the mic90 of ten c. jejuni strains was 900 micrograms/ml. of three dosage regimens tested, continuous treatment before and after the bacterial challenge, mimicking the way bss is used in the prevention of traveller's diarrhoea, was the most effective. growth inhibition was dose dependent; the high dose of 2000 micrograms per day was mor ...	1990	2347383
induction of transient hyperglycaemia in cancer patients.	serum glucose levels up to 700 mg/dl were achieved and maintained for 3 h in patients with advanced metastatic cancer by infusion of concentrated glucose solutions. even with infusions of large amounts of glucose, the maximum sustainable level of serum glucose did not exceed 700 mg/dl. the apparent ceiling of serum glucose level appeared to be due to a large and rapid loss of glucose from the kidneys. with adequate fluid volume replacement there was no rebound hypoglycaemia and there was no sign ...	2008	2394924
heme-dependent and heme-independent nitrite reduction by lactic acid bacteria results in different n-containing products.	seventy strains of lactic acid bacteria were investigated for nitrite reductase activity. two types of this activity were detected. type i was found in lactobacillus plantarum, l. pentosus and pediococcus pentosaceus. this activity is heme-dependent with ammonia as the sole product. type ii mechanism is heme-independent and reduces nitrite to no and n2o.	1990	2397159
[multiple sclerosis in health care in our country: electrophysiological, immunological and clinical analysis].	among 70 patients referred for suspected multiple sclerosis (ms) a total of 40 met criteria for definite (17), likely (12) or possible (11) diagnosis of the disease. visual evoked potentials provided evidence of cns lesion in 13 cases. abnormalities of somatosensory evoked potentials, particularly on stimulation of the posterior tibial nerve, were present in 90% of patients. brainstem auditory evoked potentials were of little use, contributing to diagnosis of one subclinical lesion; they were no ...	2008	2519355
hemodynamic and electrophysiologic effects of amlodipine, a new long-acting calcium antagonist: preliminary observations.		2008	2530867
the polymorphic oxidation of beta-adrenoceptor antagonists.		2008	2566179
pcr amplification of dna microdissected from a single polytene chromosome band: a comparison with conventional microcloning.	a novel alternative to microcloning for the production of region specific chromosomal dna is described. in this method, 'microamplification', single bands are dissected from polytene chromosomes and digested with sau3a. oligonucleotide adaptors are ligated to these fragments to provide convenient priming sites for polymerase chain reaction amplification. in this way, as much as 1 microgram of dna can be amplified from a single band. probes made from pcr amplified dna from two such dissections ha ...	2008	2587252
initiation and termination of human u1 rna transcription requires the concerted action of multiple flanking elements.	sequences in the 5' flanking region of small nuclear rna (snrna) genes are responsible for recognition of 3' end signals. formation of the pre-u1 3' end occurs at the downstream signal closest to the promoter, probably by transcription termination. we have analyzed promoter elements for their participation in formation of the 3' ends of pre-u1 rna. to do this, a human u1 rna gene with deletions in individual promoter elements was microinjected into xenopus laevis oocytes and the resulting rnas w ...	1989	2587258
post-concussional symptoms following minor head injury.	the effect of admission to hospital after a minor head injury on the incidence and duration of post-concussional symptoms was investigated. a total of 114 adults with a minor head injury were randomly allocated to admission for 24 h or to discharge from the accident department. follow-up was by postal questionnaire. this revealed that 90 per cent of patients suffered symptoms lasting an average of 2 weeks. the patients who were discharged had symptoms that lasted a shorter time. admission to hos ...	2007	2592090
diagnosis of infectious mononucleosis.		2008	2592913
the next wave: the combination of clinical work with the opportunity to serve people makes dentistry an attractive career option for women.		2008	2605768
an enzyme-linked immunosorbent assay for the quantitation of dna.		1989	2607159
[strabismus in children].		2008	2620724
[strabismus in children].		2008	2620724
study of reaction time in hemiplegics.	visual reaction time and auditory reaction time (vrt and art) were measured in 25 right hemiplegics and 25 left hemiplegics in the age group of 40-60 years. there was a significant prolongation of vrt and art in both the right and left hemiplegics as compared to normals of the same age group. art following mono-aural stimulation i.e. sound input into the right and left ear separately, was also studied in the subjects. mono-aural stimulation revealed a prolongation of the art on contralateral sti ...	2009	2634753
control of escherichia coli populations by a combination of indigenous clostridia and lactobacilli in gnotobiotic mice and continuous-flow cultures.	the function of indigenous lactobacilli in the control of other intestinal microbial species is not clear. still more controversial is the effect of dietary bacterial supplements containing lactobacilli or other species. this situation is unlikely to change unless the mechanisms that control the colonization of ingested bacteria are better understood, and until more detailed information becomes available on the mechanisms by which certain populations of indigenous bacteria can affect the populat ...	1989	2643576
[leukotrienes and lipoxins].		2009	2650889
rational drug therapy based on understanding the pathophysiology of hypertension.	increased peripheral vascular resistance is the hemodynamic hallmark of chronic hypertension. evidence suggests that ca2+ is vital in mediating vasoconstrictive mechanisms. calcium channel blockers correct the specific arteriolar vasoconstrictive mechanism without unwanted compensatory actions. human primary hypertension may also be related to volume variations in which renal influences contribute to elevated arterial pressure and diuretics may be necessary to control the hypertension. patients ...	1989	2663225
[guillain-barré syndrome and extramembranous glomerulopathy. apropos of a case].		2009	2696406