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[thromboembolism of the mesenteric vessles]. 20041133941
failure to consult specialist. 20051173090
effect of altitude relocations upon aado2 at rest and during exercise.the supine pulmonary venous admixture (shunt) has been measured at cerro de pasco, 4,350 m altitude in eight subjects native to high altitude (han) under resting condition. alveolar-arterial o2 tension difference (aado2) was also determined at rest and during exercise. the same subjects were studied again after 10 days' sojourn at sea level in lima at 150 m altitude. they were compared with four subjects from sea level (sln) who were studied first at lima and after 2 and 10 days at cerro de pasc ...20051176413
authority orientations of police officers. 20051176428
xeromammography at a community hospital. a year's experience. 20051183210
[production of tropane alkaloids in tissue cultures (author's transl)]. 20051187871
a volumetric assessment of pollen levels in the air of ann arbor, michigan. 20051196148
hyperpolarizing photoreceptors in the eye of a primitive chordate, salpa democratica. 20051198931
[bile and stress ulcer in the rat (author's transl)].the influence of bile on the ulcer formation under "restraint stress" condition was studied in rats with direct choledocho-gastrostomia resp. bile duct ligation. after 9 hrs. of immobilisation in plaster cuffs the animals with unrestricted bile flow via the choledochosstress gastrostomia showed as many ulcers as the sham-operated controls. there was no difference in the ulcer localisation, the region of the bile duct anastomosis was without any ulcer. after bile duct ligation the ulcer frequency ...19751214546
[is appendicitis still a problem in our health services?]. 20051214553
the role of the surrounding tissue in the propagation of waves through the arterial system.a theoretical analysis of the flow in arteries is presented, taking into consideration the role played by the surrounding tissues in determining the speed of propagatoion and the damping of the blood pressure pulse. this study was undertaken (a) to exhibit a method of computing the flow properties with a more nearly accurate model, (b) to see if the displacement on the skin would be related to the arterial wall displacement, and hence to pressure, velocity and flow rate of blood in the artery, a ...20051231056
[traumatic cataract and intra-ocular lens]. 20051236649
pittfalls in the diagnosis of endocrine exophthalmy. 20051242208
human placental lactogen concentration during physiological fluctuations of serum glucose in normal pregnant and gestational diabetic women.oral glucose tolerance tests (ogtt) were carried out in 9 normal pregnant women and 11 non-obese gestational diabetics in late pregnancy. all samples were analysed for the content of glucose, insulin and placental lactogen hormone (hpl). furthermore, spontaneous changes in the serum hpl concentration during a 3 h period were studied in 6 normal women in the 2nd half of pregnancy. during ogtt only small and insignificant changes in the level of hpl were observed in both the normal subjects and th ...19751242271
attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization.four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ...19761262709
[therapeutic effect of complamine in atherosclerosis and ischemic heart disease]. 20051273633
[changes in the activity of succinate dehydrogenase in the cells of different brain structures under the effect of uhf field of low intensity]. 19761274298
[scheele research and acclaim in travels to other countries. the 250th birthday of carl wilhelm scheele]. 20051287672
gangliosides and neuronal-astrocytic interactions. 20051287722
expression and release of neuroregulators during development: monoamines and neuropeptides.the turnover of catecholamines (ca) was determined in the adrenal medulla and brain of rat fetuses and pups. in general we found a considerable increase soon after birth. the expression of mrna for ca-synthesizing enzymes was also considerably enhanced in the adrenals shortly after birth. furthermore, we demonstrated increased expression of neuropeptides after birth, increased synthesis of mrna encoding for neuropeptide y in the adrenals 24 h after birth; and considerable activation of the subst ...19921306802
acoustic chiasm v: inhibition and excitation in the ipsilateral and contralateral projections of lso.when this series of experiments was begun in 1984, the activity of each lateral superior olive (lso) in the mammalian hindbrain was known to encode the hemifield of acoustic space containing a sound source. however, the almost random bilaterality of its ascending projections seemed to jumble that identification before reaching the midbrain. at the same time, electrophysiological studies of lso and its efferent target in the inferior colliculus, along with the strictly contralateral deficits in s ...20051317390
gap-43 mrna localization in the rat hippocampus ca3 field.gene expression of the axonal growth-associated protein, gap-43, has been studied in the adult rat brain by in situ hybridization histochemistry. this protein is synthesized at high levels in neuronal somata in immature and regenerating neurons, but after establishment of mature synaptic relations its synthesis generally declines sharply, thus providing a marker denoting propensity for exhibiting synaptic plasticity. detailed examination of the distribution of mrna for gap-43 in rat hippocampus ...19921317499
patterns of substance use among methadone maintenance patients. indicators of outcome.critics often cite the use of illicit drugs among methadone maintenance patients as evidence of this treatment modality's failure. the fact that methadone maintenance treatment does not lead quickly to abstinence in most clients can be a disappointment to treatment professionals and the public. by studying a cohort of 41 patients for their first year in a methadone maintenance program, this study revealed significant trends of diminished narcotic and cocaine use. however, increased benzodiazepin ...20051324987
patterns of substance use among methadone maintenance patients. indicators of outcome.critics often cite the use of illicit drugs among methadone maintenance patients as evidence of this treatment modality's failure. the fact that methadone maintenance treatment does not lead quickly to abstinence in most clients can be a disappointment to treatment professionals and the public. by studying a cohort of 41 patients for their first year in a methadone maintenance program, this study revealed significant trends of diminished narcotic and cocaine use. however, increased benzodiazepin ...20051324987
peripheral stem cells made to work. 20061347341
rediscovering wormwood: qinghaosu for malaria. 20061347342
questions about inhaled beta 2-adrenoceptor agonists in asthma.the safety of the most widely prescribed antiasthma drugs, beta 2-adrenoceptor agonists, has recently been questioned. issues such as their suitability for long-term and regular prophylactic use are addressed in this comment article by peter barnes and fan chung, who examine the possibility that the beta 2-agonists themselves contribute to worsening symptoms in asthma patients, thus setting up a vicious circle with greater use of the drugs. they conclude that it would be prudent to restrict the ...20051347433
expression of her2/neu oncogene product p185 in correlation to clinicopathological and prognostic factors of gastric carcinoma.the expression of the her2/neu gene product p185 was retrospectively analyzed in 58 patients with gastric carcinoma. the results were correlated to various clinicopathological and prognostic factors. positive membrane staining for p185 could be detected in 38% of the patients (22/58). membrane staining was significantly greater in well and moderately differentiated tumors of the intestinal type when compared with poorly differentiated lesions and carcinomas of the diffuse type (p less than 0.01) ...20061352299
reduced mrna levels for the multidrug-resistance genes in camp-dependent protein kinase mutant cell lines.we have previously shown that in chinese hamster ovary (cho) cells, a mutant cell line with a defective regulatory subunit (ri) for the camp-dependent protein kinase (abraham et al: mol. cell. biol., 7:3098-3106, 1987), and a transfectant cell line expressing the same mutant kinase, showed increased sensitivity to a number of drugs that are known to be substrates for the multidrug transporter (p-glycoprotein). in the current study we have investigated the mechanism by which camp-dependent protei ...19921352302
report from a national cancer institute (usa) workshop on quality of life assessment in cancer clinical trials.to promote the inclusion of quality of life (qol) end-points in clinical research on cancer, the national cancer institute (usa) sponsored a workshop on qol assessment in cancer clinical trials in july, 1990. experts in clinical trials and qol research formed four working groups to identify current areas of cancer treatment in which qol end-points are most important; to discuss methodologic problems in qol assessment; to address common problems in implementing clinical studies with qol end-point ...20061363776
characterization of guanosine diphospho-d-mannose dehydrogenase from pseudomonas aeruginosa. structural analysis by limited proteolysis.alginate is believed to be a major virulence factor in the pathogenicity of pseudomonas aeruginosa in the lungs of patients suffering from cystic fibrosis. guanosine diphospho-d-mannose dehydrogenase (gdpmannose dehydrogenase, ec 1.1.1.132) is a key enzyme in the alginate biosynthetic pathway which catalyzes the oxidation of guanosine diphospho-d-mannose (gdp-d-mannose) to gdp-d-mannuronic acid. in this paper, we report the structural analysis of gmd by limited proteolysis using three different ...19921370473
[initial experiences with a self-expanding metal stent in malignant ureteral compression].self-expanding metallic stents for the treatment of hydronephrosis were implanted in 12 ureters with malignant compression in 10 patients. in 3 ureters the stents were introduced percutaneously by a transrenal route; in 8 ureters introduction was transurethral and in one ureter by a combined route. patency rate after 6 months was 90.9%. in all cases the stent was able to withstand pressure by the tumour for the remainder of the patient's life. in one patient there was incrustation of both stents ...20051370762
the clinical engineer as medical laser safety officer. 20061393206
eccrine hidrocystoma: two cases of robinson and smith types.two cases of eccrine hidrocystoma, one of which is a "classic" robinson type and the other a smith type, were reported. the walls of both cysts consisted mainly of two layers of flat or low cuboidal epithelial cells with eosinophilic cytoplasm. immunostaining for s-100 protein was negative in the cells of the cyst wall of the robinson type and only weakly positive in the inner luminal layer of the smith type. electron microscopically, the smith type showed double-layered cuboidal lining and cell ...20061401509
study of acute intraoperative suprachoroidal hemorrhage.acute intraoperative suprachoroidal hemorrhage or effusion (aish) was studied in a prospective manner over the past three years. in a general cataract surgery population of 2,523 patient eyes, 15 (0.6%) experienced an aish. results of a specific surgical management technique are presented. surgical control of the aish consisted of immediate closure of the incision and application of pressure directly to the eye. this tamponades the effusion or hemorrhage, which allows coagulation and completion ...20061403754
[transient, prolonged, combined sicca syndrome of the eyes and mouth. occurrence along with a common cold in an 8-year-old girl].a girl of eight years fell ill with signs of common cold and bronchitis. already on the second day of illness, before any treatment was started, she showed symptoms of a sicca-syndrome, beginning in the eyes, later the mouth. ophthalmologic examination showed keratitis filiformis, histology of the salivary glands in the mucosa of the mouth was normal. local substitution therapy led to subjective improvement. the disorder of secretion persisted for four months only, then rapid restitutio ad integ ...20061435804
why is the phosphorus content of human milk exceptionally low?the phosphorus supply of children and adults is adequate, and usually in excess. therefore, it is surprising that in breast-fed infants phosphorus intake is very low. this is very rare among mammals. in infants three pathophysiological mechanisms argue in favour of a low, but adequate phosphorus intake in the presence of a balanced ratio of calcium to phosphorus. a low intestinal phosphorus concentration is an essential condition of an acid ph of the faeces, inhibiting the growth of potentially ...19921435825
design and inhibitory properties of synthetic bowman-birk loops.a cyclic tridecapeptide based on the sequence of an anti-tryptic loop of a bowman-birk inhibitor was synthesized, and demonstrated to be active as an inhibitor of trypsin. molecular modeling of this sequence suggested an improved sequence which demonstrated an order of magnitude improvement in the inhibitory constant.20061446974
"raynaud's disease" in migraineurs: one entity or two?two cases are reported of patients who were diagnosed as having both migraine and raynaud's disease. because they were able to achieve effective control of both headaches and extremity temperature after undergoing a comprehensive approach--utilizing medication, biofeedback, and psychotherapy--it is suggested that both conditions are manifestations of the same disorder. it is recommended that a first step in approaching concurrent diagnoses of this type involve combined treatment as is often used ...20061446993
what role will residency education take in the profession by the year 2000?residency education has enjoyed relatively slow but steady growth since its inception in the mid-1970s. a certain segment of recent graduates consider graduation from optometry school as entry level and perceive the need for additional clinical education. the creation of new residency programs and the expansion of existing ones may occur in a variety of settings. for residency education to realize its full potential, optometry must seek federal support for post-graduate clinical education. this ...20061447463
aging and immunity.the function of the immune system peaks at around puberty and gradually declines thereafter with advance in age. the age-related decline of immunological function primarily occurs in the t cell-dependent immune system and is generally associated with increase in susceptibility to infections as well as in incidence of autoimmune phenomena in the elderly. the age-related change in t cell-dependent immune functions can be ascribed to the physiological thymic atrophy which starts in an early stage o ...20061449050
caution advised when changing to new therapies. 20061458280
[psoriasis and progressive multifocal leukoencephalopathy in aids]. 20061475452
the hha protein from escherichia coli is highly homologous to the ymoa protein from yersinia enterocolitica. 19921484495
interaction between effects of hypoxia and hypercapnia on altering left ventricular relaxation and chamber stiffness in dogs.left ventricular (lv) isovolumic relaxation and chamber stiffness were examined in dogs to see how hypoxemia and hypercapnia occurring during an acute exacerbation of chronic obstructive lung disease could directly affect diastolic performance. measurements were obtained during baseline (arterial po2 approximately 200 mm hg; pco2 approximately 35 mm hg; ph approximately 7.35), hypoxia (po2 approximately 35 mm hg; pco2 approximately 35 mm hg; ph approximately 7.35), and hypoxia-hypercapnia (po2 a ...19921489118
adoptive immunotherapy of cancer: biological response modifiers and cytotoxic cell therapy.immunotherapy has been developed for the treatment of metastatic cancers refractory to conventional therapies. immunotherapy utilizes immune cells and/or biological response modifiers (brms) to induce an anti-tumor response mediated by the patient's immune system. brms, including lymphokines and cytokines, are used as single agents or in combination for cancer therapy. some brms, particularly interleukin 2 (il-2), can activate and expand in vitro lymphocytes with anti-tumor reactivity which will ...20061524952
carbohydrate specificity of the receptor sites of mistletoe toxic lectin-i.the carbohydrate specificity of mistletoe toxic lectin-i (ml-i) was studied by haemagglutination-inhibition assay. the results indicated that ml-i has a broad range of affinity for gal alpha,beta linked sequences. the galabiose (e, gal alpha 1----4gal) sequence, a receptor of the uropathogenic e. coli ligand, was one of the best disaccharide inhibitors tested. the lectin also exhibits affinity for lac(gal beta 1----4glc), t(gal beta 1----3galnac), i/ii(gal beta 1----3/4glcnac) and b(gal alpha 1- ...20061525184
acupuncture analgesia.acupuncture-produced surgical analgesia has been demonstrated in a wide variety of species under experimental and clinical circumstances. the main advantage is that no depressant drugs need to be used. the disadvantages of its use are unfamiliarity, the need for special equipment, inconsistent effects, and lack of restraint.19921533972
total anomalous pulmonary venous connection: surgical correction in a 66-year-old man.a cyanotic, debilitated 66-year-old man was referred as an emergency because of embolic arterial occlusion of the left lower extremity. subsequent investigation revealed total anomalous pulmonary venous connection. complete surgical correction was accomplished. despite a difficult postoperative hospital course, more than 3 years after operation he continues to experience improved quality of life with better exercise tolerance, freedom from further emboli and symptomatic arrhythmias, and no need ...19921540076
ontario's proposed consent laws: 1. consent and capacity, substitute decisions, advance directives and emergency treatment. 20061544072
diagnosis of sickle cell disease in chronically transfused patients.standard electrophoretic methods for the diagnosis of hemoglobinopathies are confounded in individuals chronically transfused. we present the accurate diagnosis of sickle cell disease in two such transfused patients by the application of polymerase chain reaction technology to analyze patient's hemoglobin beta-chain genes directly.19921550267
the carpal tunnel syndrome: part ii.the carpal tunnel syndrome is a compression of the median nerve within the carpal tunnel with very specific signs and symptoms. anatomical dissection of 156 wrists is presented and then the authors compare their findings with the findings of other investigators. the purpose of this article is not to present results but rather to discuss the anatomic entities involved with the syndrome and to present the open treatment modality.20061550309
[planning in the health field]. 20061553488
[local meeting series--a model for continuing education of the general practice staff].during the period january 1987 to june 1990 28 educational afternoon meetings were held for the office staff and nurses in general practice in bodø, as well as for the nurses in the bodø emergency clinic/service. office staff and nurses in the occupational health service were also invited, bringing the number up to 42. on average 40.0% of the invited persons attended the meetings. each meeting lasted 2 hours. the number attending the last meetings was so few that the series was discontinued. how ...20061557764
diagnostic value of some matrix components.although most diagnostic markers lie within the cell, a few are found in the matrix. well-known examples of these are amyloid filaments and fibrous long-spacing collagen (luse body). perhaps not so well-known are the diagnostic values of anchoring fibrils and microvillus-matrix associations. the latter two form the subject of this paper.20061557821
schizophrenia: gender and familial risk.the morbid risks for schizophrenia and any nonaffective psychosis in the first degree relatives of male and female schizophrenic probands were compared utilizing cox proportional hazards models. the schizophrenic probands (275 male; 106 female) were drawn from a larger sample of hospitalized patients obtained by systematically screening all psychiatric admissions to 15 facilities over a six-year period. proband diagnoses (dsm-iii) were based on a direct assessment of the patient and a review of ...20061560406
phospholipase c-mediated hydrolysis of phosphatidylcholine is activated by cis-diamminedichloroplatinum(ii).we have investigated the effect of cis-diamminedichloroplatinum(ii) (cddp) on signal transduction pathways. cddp treatment did not cause any change in the binding of [3h]-phorbol dibutyrate to pc-9 (human lung adenocarcinoma cell line) cells, a measure of protein kinase c activation. however, 2-h cddp treatment (20 micrograms/ml) caused approximately 200% increase in 1,2-sn-diacylglycerol (dag) production and approximately 50% decrease in inositol 1,4,5-triphosphate production. to explore the di ...19921569201
ab-interno neodymium:yag versus erbium:yag laser sclerostomies in a rabbit model.this study was undertaken to determine whether thermally-induced tissue necrosis was a factor in ab-interno contact-laser sclerostomy failure. a rabbit model was used to compare the continuous-wave neodymium (nd):yag with the pulsed erbium (er):yag laser with respect to such failure. laser energy was focused into a fused-silica fiber optic (400 microns) for the nd:yag laser (12 w; 3 to 5 seconds), and into a single-crystal, uncladded sapphire fiber optic (250 microns) for the er:yag laser (7 to ...19921574289
[fundus plication with or without proximal selective vagotomy?].the aim of this study was to determine the influence of proximal gastric vagotomy on the outcome after fundoplication. of 141 patients operated on for reflux disease between 1972 and 1988, 53 had fundoplication alone (group a) and 88 fundoplication combined with proximal gastric vagotomy (group b). the two groups were similar with regard to the severity of the reflux disease (esophagitis: a 69%, b 73%) but had a different incidence of concomitant ulcer disease (a 2%, b 55%). after a mean follow- ...20061621082
low ph deforms the influenza virus envelope.influenza virus membrane fusion is induced by low ph, which triggers an irreversible conformational change in the viral haemagglutinin (ha). the result of this change is the extrusion of the ha fusion peptide, after which it may act in the fusion of virus and endosomal membranes. here we describe electron microscopic observations on low ph-treated virus after negative staining or cryo-electron microscopy of virus in the frozen hydrated state. the results indicate a destabilization of the virus m ...19921634881
effects of norethisterone on pressor response to angiotensin ii in men.we examined the effects of norethisterone and/or mestranol on the pressor response to angiotensin ii in 20 healthy men.20061635747
network of signal transduction pathways involving lipids: protein kinase c-dependent and -independent pathways. 20061636498
adrenalin activation of beta 2-adrenoceptors stimulates morphological changes in astrocytes (pituicytes) cultured from adult rat neurohypophyses.neurohypophysial astrocytes, the pituicytes, are known to undergo morphological changes in vivo in response to stimuli that increase the demand for hormone secretion. similar changes have been induced by beta-adrenergic stimulation both in the isolated, but otherwise intact, neural lobe and in pituicytes cultured from adult rats. since the predominant beta-receptor subtype in the neural lobe is beta 2, we investigated the possibility that beta 2-receptor activation is mainly responsible for the ...19911682016
rural advanced practice nurses: a decade of growth. 20061764326
acute myocardial infarction after blunt chest trauma in young people: need for prompt intervention.we describe four cases of acute myocardial infarction in young patients, secondary to blunt chest trauma. one case was treated with intracoronary thrombolysis and angioplasty, two cases received systemic thrombolysis, and the last one did not have any reperfusion therapy. the coronary angiograms of the left anterior descending artery showed thrombosis in two cases, coronary dissection in one case, and no morphological lesions in the other. we encourage the early performance of angiographic studi ...20061764738
analysis of high psa n-cam expression during mammalian spinal cord and peripheral nervous system development.using a monoclonal antibody that recognizes specifically a high polysialylated form of n-cam (high psa n-cam), the temporal and spatial expression of this molecule was studied in developing spinal cord and neural crest derivatives of mouse truncal region. temporal expression was analyzed on immunoblots of spinal cord and dorsal root ganglia (drgs) extracts microdissected at different developmental stages. analysis of the ratio of high psa n-cam to total n-cam indicated that sialylation and desia ...19911769342
[clinico-morphological signs of different forms of destructive pancreatitis].clinicomorphological comparisons in 434 cases of destructive pancreatitis showed that macroscopic signs of destruction develop in the first 12 hours from the onset of the attack. the elaborated criteria make it possible to evaluate the main morphological components of destructive pancreatitis--pancreonecrosis proper, parapancreatitis, peritonitis, and "polyvisceritis" and to use therapeutic measures on an individual basis.20061779556
comparing clinical tests of visual loss in cataract patients using a quantification of forward light scatter. 20061794427
inhibitory effect of cimetidine on graft survival of allotransplanted rats submitted to an active-passive enhancement protocol.the objective of the present study was to determine whether cimetidine, a type-2 histamine receptor antagonist, inhibits the immunological enhancement of allografted rats achieved by treatment with donor antigen plus anti-donor antibody. groups of rats submitted to this active-passive enhancement protocol and treated ip with 30 (apec 30; group i; n = 4) or 60 (apec 60; group ii; n = 8) mg/day cimetidine for 14 days had a significantly shorter graft survival (20.2 +/- 5.1 and 11.1 +/- 2.6 days, r ...19911797288
inhibitory effect of cimetidine on graft survival of allotransplanted rats submitted to an active-passive enhancement protocol.the objective of the present study was to determine whether cimetidine, a type-2 histamine receptor antagonist, inhibits the immunological enhancement of allografted rats achieved by treatment with donor antigen plus anti-donor antibody. groups of rats submitted to this active-passive enhancement protocol and treated ip with 30 (apec 30; group i; n = 4) or 60 (apec 60; group ii; n = 8) mg/day cimetidine for 14 days had a significantly shorter graft survival (20.2 +/- 5.1 and 11.1 +/- 2.6 days, r ...19911797288
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...19911820797
[anti-inflammatory activities and effect of rhizoma alismatis on immune system].10 and 20 g/kg ig of rhizoma alismatis (ra) markedly decrease the clearance rate of charcoal particles in mice, but have no significant effect on the weight of immune organs, or on the content of serum antibody hemolysin and immunoglobulin g and the delayed footpad edema induced by sheep red blood cell. the contact dermatitis of mouse pinnae immunized with dinitrochlorobenzene is inhibited by ra when it is given before challenge. in addition, ra 20g/kg suppresses the swelling of mouse rinnae ind ...19911820797
the sojourn time and its use in pharmacology.a short review on some pharmacokinetic parameters (mean residence time, sojourn time, transit time) is given in relation to compartmental models and some examples and application are discussed. in particular the use of the sojourn time is suggested because this parameter can give useful informations when comparing the pharmacokinetics of different drugs or in pharmacodynamics.20071820930
[menopausal hospital units]. 20071821060
familial predisposition for herniation of a lumbar disc in patients who are less than twenty-one years old.the parents of sixty-three patients who were less than twenty-one years old and who had operatively confirmed herniation of a lumbar disc were interviewed regarding a history of sever back pain, sciatica, and herniated disc, to determine whether aggregation of herniation of a lumbar disc occurs in families of patients in this young age-group. the parents of sixty-three additional patients who had a non-spinal orthopaedic diagnosis (control group) were matched for age and sex with the study group ...20071824705
a nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins.we have developed a novel nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins. this method is derived from previously described protocols developed for the same purpose by using radioactively labeled dna probes containing protein recognition sequences. this nonradioactive strategy relies upon the use of a small hapten, digoxigenin. fusion proteins expressed from the recombinant bacteriophage lambda gt11/lambda zap are immobilized on nitrocellulose fi ...19911828652
a nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins.we have developed a novel nonradioactive screening method for cloning genes encoding sequence-specific dna binding proteins. this method is derived from previously described protocols developed for the same purpose by using radioactively labeled dna probes containing protein recognition sequences. this nonradioactive strategy relies upon the use of a small hapten, digoxigenin. fusion proteins expressed from the recombinant bacteriophage lambda gt11/lambda zap are immobilized on nitrocellulose fi ...19911828652
[the hemodynamic effects of isradipine and nifedipine in hypertension].hemodynamic effects of isradipine and nifedipine in hypertension myocardial wall tension is an important determinant of the oxygen demand, the function and the degree of hypertrophy of the left ventricle. myocardial wall tension should be influenced more favourably by a non-cardiodepressive antihypertensive than by a potentially cardiodepressive one. therefore, we investigated the effects of an intravenous infusion of the calcium antagonists isradipine (i; 0.4 mg; 3,5-pyridinecarboxylic acid, 4- ...20071839125
processing of the glycoprotein of feline immunodeficiency virus: effect of inhibitors of glycosylation.the processing and transport of the envelope glycoprotein complex of feline immunodeficiency virus (fiv) in the persistently infected crandell feline kidney (crfk) cell line were investigated. pulse-chase analyses revealed that the glycoprotein is synthesized as a precursor with an mr of 145,000 (gp145) and is quickly trimmed to a molecule with an mr of 130,000 (gp130). treatment of gp130 with endoglycosidase h (endo h) resulted in a protein with an mr of 75,000, indicating that nearly half the ...19911847441
regulation of alcohol consumption by the renin-angiotensin system: a review of recent findings and a possible mechanism of action.the renin-angiotensin system has traditionally been associated with the regulation of fluid and electrolyte balance. in this review we summarize the data which ascribes a completely new function to this system, i.e., the regulation of alcohol consumption. in addition, we suggest a possible mechanism for this effect based on the concept of a satiety or stop process. the approach taken was to examine the effect on alcohol intake of a wide variety of drug, genetic, dietary, surgical and neurosurgic ...20071852316
determination of ring- and n-substituted amphetamines as heptafluorobutyryl derivatives.an improved derivatization method for analysing 12 ring- and n-substituted amphetamine-derivatives in body fluids or seized materials by gas chromatograph combined either with mass spectrometer, electron capture or nitrogen phosphorus detector is presented. heptafluorobutyric anhydride is used as derivatization reagent. no heating or standing period is needed in this procedure. most of the drugs considered were distinguishable from each other according to their retention times and all of them ac ...20061855720
determination of ring- and n-substituted amphetamines as heptafluorobutyryl derivatives.an improved derivatization method for analysing 12 ring- and n-substituted amphetamine-derivatives in body fluids or seized materials by gas chromatograph combined either with mass spectrometer, electron capture or nitrogen phosphorus detector is presented. heptafluorobutyric anhydride is used as derivatization reagent. no heating or standing period is needed in this procedure. most of the drugs considered were distinguishable from each other according to their retention times and all of them ac ...20061855720
major histocompatibility complex (mhc) class ii region in humans. 20071855818
characterization of activation and deactivation pathways of 4-(n-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (nnk) in rat hepatocytes.we have characterized the metabolism of 4-(n-nitrosomethylamino)-1-(3-pyridyl)-1-butanone (nnk) in cultured rat hepatocytes and have established the relationship between various metabolic pathways and single-strand breaks (ssb) in dna. metabolism of [5-3h]-nnk by carbonyl reduction, alpha-carbon hydroxylation and pyridine n-oxidation was linear from 0.5 to 6 h with 0.25-2 x 10(6) hepatocytes. using an alkaline elution assay, we observed that nnk induces ssb in dna in a dose- and time-dependent m ...19911855907
body composition of low-birth-weight infants determined by using bioelectrical resistance and reactance.we tested the hypothesis that bioelectrical resistance and reactance are indices of total body water (tbw) and extracellular water (ecw), respectively. infants less than 2500 g in birth weight were studied while less than 24 h old and at 4-7 d of age. tbw (n = 32) was measured by h2(18)o dilution and ecw (n = 34), by bromide dilution. measurements were made by using an impedance plethysmograph from each of four electrode pairs. bioelectrical resistance correlated inversely with tbw (r = -0.683). ...20071858693
systematized progradient multiple combined melanocytic and blue nevus.a 44-year-old woman was diagnosed as having unilateral multiple progradient pigmented macules and papules of the upper extremity and adjacent part of the back. microscopically increased amounts of melanin and melanocytes in the basal layer of the epidermis in the early developmental stage of macules were seen. combinations of blue nevus with junctional or compound nevus or with a simple proliferation of melanocytes in the epidermis were present in the papules. the question of prognosis is discus ...20071867359
two years as a veterinarian in africa: thoughts and observations. 20071874661
head group specificity in the regulation of phosphatidylcholine catabolism in rat hepatocytes.previous studies have shown that the catabolism of pc is regulated in choline-deficient hepatocytes and the concentration of phosphatidylcholine (pc) might be an important regulatory factor (tijburg, l.b.m., nishimaki-mogami, t. and vance, d.e. (1991) biochim. biophys. acta, 1085, 167-177). in the present study we investigated the head group specificity of the regulation of pc catabolism. supplementation of choline-deficient rat hepatocytes, prelabeled with [3h]choline, with dimethylethanolamine ...19911892886
predominant expression of lambda light chain in adult cases with non-t-cell acute lymphocytic and chronic myelogenous leukemia in lymphoid blast crisis.the authors investigated cytoplasmic immunoglobulins of the leukemic cells from 20 adult cases with non-t-cell acute lymphocytic leukemia (all) and from three cases with chronic myelogenous leukemia in lymphoid blast crisis using immunoelectron microscopy. they also studied these cases using various monoclonal antibodies. of the 23 examined cases, nine were negative for both heavy and light chains of immunoglobulins; the authors defined these as common all. two cases were positive for the mu cha ...20071906773
the 1990 merck frosst award. ischemic and reperfusion injury in the heart. cellular mechanisms and pharmacological interventions.reperfusion in the heart represents an important form of tissue injury, particularly in view of the emerging importance of reperfusion protocols aimed at salvaging the ischemic myocardium. both the manifestations and the causes of reperfusion injury are multifold. with respect to the former, reperfusion injury can be characterized by various abnormalities including development of arrhythmias, contractile dysfunction, ultrastructural damage as well as various defects in intracellular biochemical ...20071913318
clinical testing of thermally stimulated cardiovascular oscillations in man.the study assessed the physiological validity of an automatic thermal stimulation method to induce synchronised oscillations in the neural cardiovascular control system.19911913758
nasopharyngeal carcinoma with spinal secondaries.nasopharyngeal carcinoma has been reported to have a higher incidence of distant metastases as compared to other head and neck cancers. distant metastases of nasopharyngeal carcinoma has been reported in the bones, lungs, liver, distant lymph nodes, brain and porta hepatis. this report presents a case of nasopharyngeal carcinoma with secondaries in the extradural space at the thoracic level of the spinal cord which hitherto has been an unreported site.20071919352
imaging of the temporomandibular joint in juvenile rheumatoid arthritis. 20071932822
results of cochlear implants in children.about 700 children throughout the world have been implanted to date. placing a cochlear implant represents no particular problem in the child. the incidence of complications is not high, being of about the same proportion as that in the adult. to obtain the best results, the selection of patients must be correct and carried out by a multi-disciplinary team of specialists, while the operated child must be subject to regular and intensive rehabilitation. the results appear to have become more sati ...20071950547
controversies in otoplasty.in the last 30 years many surgeons, plastic as well as ent surgeons, have been increasingly concerned with the correction of protruding ears. there are many controversial points of view regarding the preferable surgical approach. each surgeon is claiming to find the best solution to this specific issue. to find an acceptable solution, various techniques tackling all the components of the deformity are screened. my preferred technique for the reconstruction of prominent ears, using the best of se ...20071950548
doppler flow velocities in single umbilical arteries.fetal compromise has been associated with an umbilical artery waveform pattern of low or absent diastolic velocity relative to systolic velocity. fetuses with single umbilical arteries have an increased risk of major malformations, mortality, retarded fetal growth, and prematurity. in this study doppler flow velocities were obtained in 13 fetuses (four twin fetuses and nine singletons) with a single umbilical artery. five (38%) fetuses, consisting of four singletons and one twin, had anomalies. ...20071951526
hospital outbreak of scabies stemming from two aids patients with norwegian scabies. 20071971073
p-glycoprotein and progesterone receptor in human breast cancer. 19901974809
trade-off between gestational age and miscarriage risk of prenatal testing: does it vary according to genetic risk?it has been generally assumed that as genetic risk rises, so the higher procedure-related miscarriage rates of diagnostic tests done earlier in gestation become more acceptable. to test the hypothesis a decision tree was used, in which the only differences between two tests a and b were that a was carried out earlier in pregnancy and was more likely to cause miscarriage. over a wide range of rankings for the three outcomes (procedure-related miscarriage of a normal baby, early termination of pre ...20051978126
[laser therapy in acute nonspecific epididymo-orchitis].laboratory experiments were followed by clinical investigations of low-intensity laser radiation (lr) feasibility in therapy of acute epididymo-orchitis. a total of 117 patients aged 15-68 were treated with mild, moderate and severe scrotal inflammation. the response was compared to that in physiotherapy (54 patients) and early surgery (40 patients). it proved higher by 38.5%, the proportion of the treatment failure diminished from 22.2% for conservative and 15% for surgical management to 7.7%. ...20072063504
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