Publications

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adapting theory z to nursing management. 20103645461
unendurable illness. 20133647982
computerized speech-recognition and conversation. 20133666980
asymptotic relative efficiency. 20133717280
[normal natural killer activity (nk-activity) in patients on a chronic dialysis program]. 20133719629
gated cardiac imaging using low-field nmr. 20133749263
reduction of immunoreactive prostacyclin metabolite after paralysis in ventilated preterm infants.levels of the stable metabolite of prostacyclin, 6-keto-prostaglandin f1 alpha (6-keto-pgf1 alpha) were measured by radioimmunoassay during the first 48 hours of life in a group of 20 infants ventilated for the respiratory distress syndrome in whom a simultaneous record of respiratory activity was made. 6-keto-pgf1 alpha was significantly lower when the infants were paralysed (p = 0.0004) than when they were breathing spontaneously. elimination of the capacity for spontaneous respiration may red ...20133754206
epidemiologic studies on possible health effects of intake of pyrolyzates of foods, with reference to mortality among japanese seventh-day adventists.to elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one concerning the possible association of broiled fish consumption with cancer and the other concerning the cancer mortality among japanese seventh-day adventists. the main findings of these studies are described.19863757950
influence of antibiotics on the faecal excretion of bile pigments in healthy subjects.we have evaluated the effects of 10 antibiotics, given orally for 6 days to healthy subjects, on faecal excretion of urobilinogen. intake of bacitracin, vancomycin, clindamycin, erythromycin, and ampicillin resulted in a pronounced suppression of the faecal excretion of urobilinogen (p less than 0.05). intake of doxycycline, metronidazole, nalidixic acid, ofloxacin, and trimethoprim/sulphamethoxazole had no significant effect. the effects of three antibiotics-ampicillin, clindamycin, and metroni ...20133775264
anticonvulsant drugs and bone metabolism.the influence of chronic antiepileptic treatment on bone metabolism has been investigated in 52 adult epileptics, who had normal dietary intake, sunlight exposure and daily living activities. none of the patients had symptoms or signs suggestive of osteomalacia. serum phosphate levels were significantly decreased and serum alkaline phosphatase levels were significantly increased in the patients compared with matched controls. calcitonin values and bone mineral content, measured by single photon ...20133811834
aluminum bone disease. (a case study). 20133848476
survival analysis of periodontal sites before and after periodontal therapy.periodontal diseases appear to progress with bursts of destructive activity at individual sites. one effect of treatment might be to diminish the frequency of such bursts. survival analysis was employed to seek such effects on the periodontal sites of 16 individuals with prior evidence of destructive periodontal disease. the subjects were monitored at bi-monthly intervals and actively breaking down sites were detected using attachment level measurements and the tolerance method of analysis. when ...19853860518
clinical and laboratory studies of a family with a high prevalence of juvenile periodontitis.the form of periodontitis with onset at puberty and affecting predominantly the first molars and incisors is called juvenile periodontitis (jp). the disease has been the object of intense study because from its analysis may come insights into understanding other, more common, forms of periodontitis. we recently had the opportunity to study an unusual family in which both parents developed jp in their teens. we did clinical examinations, measured leukocyte chemotaxis, analyzed the pocket microflo ...19853863910
[myocardial cellular mechanism of action of calcium antagonists]. 20133905004
the in vitro production of anti-dna antibody by cultured peripheral blood or tonsillar lymphoid cells from normal donors and sle patients.anti-dna antibody responses by cultured circulating lymphocytes from sle patients and by the tonsillar lymphoid cells of normal donors were detected and enumerated by a sensitive specific elisa of culture supernatants, or by a hemolytic anti-dna pfc assay. although spontaneous igm and igg anti-dna and anti-ssdna responses were characteristic of sle lymphocytes and spontaneous igm anti-ssdna responses were characteristic of tonsillar lymphocytes, the circulating lymphocytes of normal controls nev ...20143905965
persistence of antibodies to pneumococcal vaccine in patients with chronic renal failure.antibody response to the 14-valent pneumococcal capsular polysaccharide vaccine was measured by the enzyme-linked immunosorbent assay (eia) in 17 renal allograft recipients, 29 azotemic, 11 hemodialysis, and 33 control patients. the igg, igm, and iga antibodies were measured against six pneumococcal antigen types 1, 3, 4, 6a, 8, and 19f. the control patients had the best antibody responses in the igg and iga antibody classes and the renal allograft recipients in the igm class. the renal allograf ...20143910915
percutaneous balloon catheter nephrostomy guided by ultrasound. results of a new technique.a new method for percutaneous nephrostomy is described. the renal pelvis is punctured guided by ultrasound and after dilatation of the tract a 10f silicone balloon catheter is inserted. the procedure was successful in 51 of 52 attempts (98%). the catheters were maintained from two to 150 days. eight catheters slipped out unintended (16%) 27 to 86 days after the insertion. no serious complications were seen.20143911377
[bridge design in difficult defect cases]. 20133912758
[the prayer of the anxious patient]. 20143969750
doomsday: friday the 13th of november, 1987 or out of gas, the end of the world is coming. 20133969847
doomsday: friday the 13th of november, 1987 or out of gas, the end of the world is coming. 20133969847
ectopic pituitary grafts in mice: hormone levels, effects on fertility, and the development of adenomyosis uteri, prolactinomas, and mammary carcinomas.some endocrinological consequences of grafting hypophyses of mice to sites distant from the hypothalamic-pituitary portal vessels were investigated. serum prl levels in recipients rose within 3 weeks to levels seen during pregnancy, resulting in a premature increase in serum progesterone (p) levels. after 7 weeks, luteolytic effects were evident in balb/c females, and p values had plateaued in the range of those seen in normal adult animals, while in balb/c x c3h f1 hybrids, this effect was dela ...19853971922
metastatic nontraumatic clostridium septicum osteomyelitis.nontraumatic clostridial infections are rare, but need to be diagnosed and treated early or high morbidity and mortality rates result. we believe that this is the first reported case of metastatic nontraumatic clostridium septicum osteomyelitis. early treatment with surgical debridement and parenteral antibiotics without hyperbaric oxygen was used. an associated occult rectal malignancy was discovered and treated.19853980945
pulmonary arterial luminal diameters in relation to the distribution of the lesions associated with canine dirofilariasis. 19854004658
in vitro cytotoxicity of glycol ethers and oxidation products in cho cells.the cytotoxicity of several glycol ethers and of some of their oxidation products, the corresponding alkoxy acetates, was compared in chinese hamster ovary (cho-k1) cells without metabolic activation. cytotoxicity was measured in terms of cloning formation ability, and ec50 values (concentrations allowing 50% of the seeded cells to form colonies) were estimated. the results, in the case of unmetabolized glycol ethers tested, showed an increase in toxicity with increasing chain length. the cytoto ...20144024159
path analysis of family resemblance for cranio-facial traits in andhra pradesh nuclear families and twins.path analysis of 12 cranio-facial measurements from a sample of nuclear families and twins from andhra pradesh, india is used to test hypotheses about the familial transmission of these traits. for bigonial breadth and ear dimensions, the transmission from parent to child is consistent with simple autosomal polygenic inheritance, but length, breadth and circumference of the head, facial breadth and nose dimensions show evidence of transmission in excess of polygenic expectations. additional non- ...20124041159
sensitivity of capnocytophaga species to bactericidal properties of human serum.capnocytophaga is a newly described genus of gram-negative bacteria which can cause serious oral and extraoral infections in the susceptible host. in the present study, sensitivity of capnocytophaga spp. to the bactericidal properties of human serum was investigated. laboratory strains representative of capnocytophaga sputigena, c. ochracea, and c. gingivalis and seven oral isolates of capnocytophaga spp. obtained in primary culture were determined to be sensitive to killing by pooled normal ser ...19854044029
the effect of prompt local cooling on oedema formation in scalded rat paws.a standardized, reproducible burn model on rat paw was used and the effect of prompt local cooling on the oedema formation was measured using a newly developed non-invasive method. a transient reduction in oedema formation was observed lasting for a longer period of time with decreasing temperature down to 0 degrees c and increasing cooling time up to 120 min. the decrease in oedema formation was followed by an increase towards or above the amount of oedema in untreated scald injury. this post-c ...19854063871
disseminated blastomycosis with intrauterine transmission. 20144071192
creatine kinase mb and m-mode echocardiographic changes in cardiac contusion.cardiac contusion was suspected in 95 patients with severe blunt chest trauma of whom 93 did not require hospitalization. creatine kinase (ck) mb isoenzyme activity was elevated over 4.0 u/l in 10 (10.5%) patients (ck mb positive) by between 2% and 8% (mean +/- se 4.1 +/- 0.6%), when the total ck was 296 +/- 74 (mean +/- se). two patients had a pericardial rub. m-mode echocardiography was performed on 16 patients: 7 ck mb positive (ck mb+) and 9 ck mb negative (ck mb-) without the physician's kn ...20094096487
striatal tyrosine hydroxylases with high and low affinity for tyrosine: implications for the multiple-pool concept of catecholamines. 19734148015
the influence of spinal transection on central nystagmus. 19644157949
[hypogonadotrophic hypogonadism in males. discussion. long-term therapeutic results]. 20144200226
[an unusual oesophageal foreign body]. 20144200315
[clinical observations on a new preparation with hepatoprotective action]. 20114234340
[development and current status of otolaryngology in moldavia]. 20114245867
some pharmacological properties of a synthetic oxytocin analogue [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist to the neurohypophysial hormones.1. a synthetic oxytocin analogue, [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), has been tested as an antagonist to the actions of oxytocin and vasopressin on the uterus, the mammary gland and blood pressure.2. the analogue inhibited the response of the isolated rat uterus to both oxytocin and vasopressin without itself stimulating the uterus to contract. the responses to equipotent doses of oxytocin and vasopressin were inhibited equally. there was little o ...19704321760
some pharmacological properties of a synthetic oxytocin analogue [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist to the neurohypophysial hormones.1. a synthetic oxytocin analogue, [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), has been tested as an antagonist to the actions of oxytocin and vasopressin on the uterus, the mammary gland and blood pressure.2. the analogue inhibited the response of the isolated rat uterus to both oxytocin and vasopressin without itself stimulating the uterus to contract. the responses to equipotent doses of oxytocin and vasopressin were inhibited equally. there was little o ...19704321760
[alpha fetoprotein in hemorrhagic ascitic fluid in a case of hepatocellular carcinoma]. 20154356944
adhesive strips in the closure of wounds in outpatient surgery in children. 20154378984
the paraproteinemias. ii. 20154380090
inhibition of hepatic ribonuclease activity by chronic administration of phenobarbitone. 19704394767
amino acid sequence of a peptide containing the active cysteine residue of histidine ammonia-lyase.1. oxidized (polymerized) histidine ammonia-lyase from pseudomonas testosteroni was activated with dithiothreitol and the reduced disulphide-linked cysteine residues of the native enzyme were carboxymethylated with iodo[(14)c]acetate. 2. the activity of the carboxymethylated enzyme was similar to that of the polymerized form and approx. 15% of that of the fully reduced form. 3. a tryptic digest of the [(14)c]carboxymethylated enzyme contained only one radioactive peptide. 4. the amino acid seque ...19744422650
"no more home deliveries". 20154485328
training of practical work instructors. 20154495649
[late results after surgery of temporomandibular joint luxation by mucosa excision and preparation of parapharyngeal pockets]. 20154508535
[problems of values and objectives in planned change]. 20154531521
suppressor cells in the rabbit appendix. 19744547314
lipid composition of xanthomas of different types. 20154576167
[the role of alcohol in therapy]. 20154601159
degree of human genetic isolation measured by isonymy and marital distances in two communities in an italian alpine valley. 19724636780
the profession of medicine. 20154644652
[study of the chemical composition of low-protein diets for patients with chronic renal insufficiency]. 20144664451
a rapid method for the electrophoresis of chromatin proteins. 19734723239
bone-conduction threshold sensitivity in relation to mastoid sclerosis. 20154744955
[treatment of herpes zoster with emetine]. 20164767947
medical education, medical care, and society in sweden. 20164818471
abnormal postural reflexes. 20164847456
clinical and laboratory study of a new diuretic agent ("vectren") in pregnancy: a comparison with a diuretic agent in current use ("enduron"). 20164889612
biological and chemical comparison of butanol- and phenol-water extracted lipopolysaccharide from capnocytophaga sputigena. 19836227738
effect of human leukocyte extracts and gingival exudate on periodontopathic bacteria.the effect of leukocyte hydrolytic enzymes on periodontopathic bacteria was examined in vitro. a frozen and thawed extract of human peripheral blood leukocytes (le) and human gingival crevicular exudate (ge) were shown to be able to cause the release of 50% of the radioactivity from a leukotoxic strain of actinobacillus actinomycetemcomitans (aa y4), labeled by 14c. a nonleukotoxic strain (aa 653) was shown to be more susceptible to both le and ge, up to 68% of the total radioactivity was solubi ...19836345380
ultrastructural studies of the effect of human leukocyte extracts on periodontopathic bacteria.human gingival crevicular exudate (ge) and leukocyte extracts (le) were previously shown to be able to release the bulk of radioactivity from a variety of 14c-labeled oral bacteria. the present study demonstrates that the release of radiolabel by these enzymatic agents from two periodontopathic bacteria (actinobacillus actinomycetemcomitans strain y4 and capnocytophaga sputigena strain 4) is accompanied by both cell wall and cytoplasmatic damage. the possible role of bacterial products released ...19836345381
sodium fluoride susceptibilities of suspected periodontopathic bacteria.utilizing a blood-based medium, we determined the minimum inhibitory concentrations (mic's) to sodium fluoride (naf) of 45 bacterial strains representing 22 oral species. bacterial susceptibility ranged from 128 micrograms/ml to 2048 micrograms/ml. of those organisms tested, actinobacillus actinomycetemcomitans, capnocytophaga sputigena, capnocytophaga gingivalis, capnocytophaga ochracea, and actinomyces viscosus were susceptible at lower levels of naf.19836574154
[capnocytophaga sputigena in sinusitis].the genus capnocytophaga was reported in the literature for the first time in 1979. capnocytophaga are fusiform gram-negative, slowly growing bacteria that require a high pco2. they belong to the normal buccal flora and they are reported as pathogens in infections of the periodontal region with progressive periodontitis and in septicaemia in patients with immunodeficiencies and buccal ulcerations. the present paper is the first to report capnocytophaga sputigena as a pathogen in sinusitis. the p ...19836670527
cellular fatty acids of capnocytophaga species.the cellular fatty acid composition of 18 clinical isolates and 4 reference strains of capnocytophaga species (capnocytophaga ochracea, capnocytophaga gingivalis, and capnocytophaga sputigena) was determined by gas-liquid chromatography. the fatty acid profiles of the 22 cultures were essentially identical and were characterized by major amounts (60% or greater) of a saturated, iso-branched-chain, 15-carbon acid (13-methyl-tetradecanoate) and the presence of two relatively uncommon saturated, is ...19827153332
[septicemia caused by capnocytophaga sputigena]. 19817290958
biological and chemical characterization of endotoxin from capnocytophaga sputigena.an endotoxin was isolated from capnocytophaga sputigena strain 4 by a modification of the hot phenol-water method. the extraction procedure yielded a lipopolysaccharide which accounted for approximately 1.5% of the dry weight of the cells. the material was composed of 18.6% lipid (as c(15) fatty acid), 46.5% neutral sugar including 9.6% hexose, 18.3% 6-deoxy sugar, 1.0% 2-keto-3-deoxy sugar, and 4.8% heptose. hexosamine, protein, and phosphorus were found in quantities amounting to 9.0, 2.9, and ...19807358428
detection of a fibroblast proliferation inhibitory factor from capnocytophaga sputigena.the addition of a sonic extract of capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. the inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). the growth inhibition was not due to alterations in culture medium, ph or ionic strength, or to the effects of the c. sputigena lipopolysaccharide.19807358430
effective method for discriminating between oral bacterial and human alkaline phosphatase activity.alkaline phosphatase (alpase) activity was quantitatively compared in various kinds of oral bacteria. high alpase activity was detected in 3 species of periodontal bacteria, porphyromonas gingivalis, prevotella intermedia and capnocytophaga sputigena. the alpase activity detected in these bacteria was almost completely inhibited in the presence of 1% sodium dodecyl sulfate (sds). by contrast, the activity of mammalian alpase isoenzymes was not inhibited at all even in the presence of 1% sds. the ...19947478753
microflora in adult periodontitis.the subgingival microflora of adult periodontitis was studied in 8 adults (36-47 years) and compared with that of 10 periodontally healthy individuals (36-43 years). a total of 64 periodontal lesions were examined, and classified according to the attachment level in three categories: attachment loss > 6 mm, attachment loss 4-6 mm and attachment loss < 4 mm. also for comparative purposes 20 gingival sulci were evaluated. samples were taken using three standardized paper points and were incubated ...19957494174
an approach to efficacy screening of mouthrinses: studies on a group of french products (i). staining and antimicrobial properties in vitro.there is a large and increasing number of oral hygiene products available to the general public. as such, it is difficult to demonstrate efficacy for all in long-term home-use studies. the aim of this project was to determine whether screening studies could position the activity and efficacy of a number of antiseptic mouthrinses, available in france, by comparison with an established product. this study reports the experiments in vitro. the products under test were, 4 containing chlorhexidine (e ...19957593703
[aortic endocarditis due to capnocytophaga sputigena]. 19957603114
properties of alkaline phosphatase in the gingival crevicular fluid.the isoenzymic properties of the alkaline phosphatase (alp) of the gingival crevicular fluid (gcf) were investigated and compared with those in other cells, such as human polymorphonuclear leukocytes (pmns), and human periodontal ligament cells (pdls), and with those of three species of periodontopathic bacteria: porphyromonas gingivalis 381 (p. gingivalis), prevotella intermedia atcc25611 (p. intermedia), and capnocytophaga sputigena atcc33123 (c. sputigena). the biochemical properties of the i ...19957796488
bacteremia by multidrug-resistant capnocytophaga sputigena.a case of bacteremia caused by a multiresistant strain of capnocytophaga sputigena in a patient with hematological malignancy is described. the strain presented with a pattern of marked resistance to beta-lactams, with mics of > 256 mg/liter for ampicillin, ticarcillin, piperacillin, cefazolin, and cefuroxime, 64 mg/liter for cefotaxime, and 32 mg/liter for ceftazidime. in addition, the mic of ciprofloxacin was 16 mg/liter. both of these groups of antimicrobial agents are frequently used in the ...19948027314
bactericidal activities of synthetic human leukocyte cathepsin g-derived antibiotic peptides and congeners against actinobacillus actinomycetemcomitans and capnocytophaga sputigena.actinobacillus actinomycetemcomitans and capnocytophaga spp. are gram-negative bacteria implicated in the etiology of periodontal disease (particularly in individuals with neutrophil defects) and life-threatening systemic infections. they are resistant to many antibiotics of microbial origin but are sensitive to the nonoxidative microbicidal action of neutrophils. these organisms are susceptible to the microbicidal effect of cathepsin g but are killed by two distinct mechanisms. the purpose of t ...19938109940
hla-d and t lymphocyte reactivity to specific periodontal pathogens in type 1 diabetic periodontitis.bacterial antigen fragments complexed with class ii major histocompatibility molecules (hla-d) on antigen presenting cells (apcs) stimulate cd4+ t lymphocyte proliferation, presumably to protect the host. this study examined these responses to antigens of two periodontal pathogens in four groups (n = 15) of age- (young adult) and sex-matched caucasian subjects with or without type 1 diabetes and moderate to severe periodontitis: group dp = diabetics with periodontitis; group dnp = diabetics with ...19938277407
capnocytophaga sputigena bacteremia associated with acute leukemia.during a three-year period, capnocytophaga sputigena bacteremia occurred in three patients with acute leukemia receiving induction therapy on a hematology ward. oral pathology such as periodontitis or severe mucositis was considered to be the most likely source of bacteremia. all three blood culture isolates were identified as that species by deoxyribonucleic acid (dna) homology studies. because of the phenotypical similarity of capnocytophaga species, it is difficult to differentiate them by co ...19938360517
in vitro antimicrobial activity of the human neutrophil cytosolic s-100 protein complex, calprotectin, against capnocytophaga sputigena.calprotectin is a complex of two anionic proteins found in abundance in the cytosol of neutrophils, certain macrophages, and oral epithelial keratinocytes. bacteria of the genus capnocytophaga are pathogens of periodontal origin which can cause systemic infection in neutropenic subjects. recently, it has been observed that capnocytophaga may be internalized by neutrophils within the cytosol rather than within a membrane-delimited phagosome. the purpose of this study was to test the in vitro anti ...19938423249
[subgingival distribution of periodontopathic bacteria in periodontic patients and susceptibility of these bacteria to minocycline-hcl].the present study was carried out to examine the distribution of six periodontopathic bacteria in deep periodontal pockets and to reconfirm the effect of periocline on these periodontopathic bacteria. samples from sixty-two periodontal pockets were collected at pocket depths of over 4 mm in twenty-one periodontitis patients aged 43 to 75 years. after sampling, periocline was applied topically to the selected pockets once a week for four weeks and reexamined. the detected rates of the periodontop ...19958583161
degradation of lactoferrin by periodontitis-associated bacteria.the degradation of human lactoferrin by putative periodontopathogenic bacteria was examined. fragments of lactoferrin were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis, and measured by densitometry. the degradation of lactoferrin was more extensive by porphyromonas gingivalis and capnocytophaga sputigena, slow by capnocytophaga ochracea, actinobacillus actinomycetemcomitans and prevotella intermedia, and very slow or absent by prevotella nigrescens, campylobacter rectus ...19968961558
novel fnr homologues identified in four representative oral facultative anaerobes: capnocytophaga ochracea, capnocytophaga sputigena, haemophilus aphrophilus, and actinobacillus actinomycetemcomitans.based upon dna sequence data and positive immunochemical reactivity of expressed protein, novel homologues of the fnr family were identified in four representative oral facultative anaerobes: capnocytophaga ochracea, capnocytophaga sputigena, haemophilus aphrophilus, and actinobacillus actinomycetemcomitans. the similarity to e. coli fnr and to hlyx (itself 71% similar to e. coli fnr, while regulating expression of hemolysin operon in actinobacillus pleuropneumoniae) was estimated from the deduc ...19968998988
myeloperoxidase isoform activities released by human neutrophils in response to dental and periodontal bacteria.myeloperoxidase is an enzyme released by polymorphonuclear leukocytes which has been used, experimentally, as an indicator of periodontal disease activity when measured in gingival crevicular fluid. there are three myeloperoxidase isoforms: mpo i, mpo ii and mpo iii. we examined the activities of myeloperoxidase isoforms released by neutrophils in response to serum-opsonized actinobacillus actinomycetemcomitans, haemophilus aphrophilus, eikenella corrodens, capnocytophaga sputigena and streptoco ...19979151641
hla-d types and serum igg responses to capnocytophaga in diabetes and periodontitis.serum igg responses to the cell envelope proteins (ceps) from capnocytophaga sputigena, capnocytophaga ochracea, and capnocytophaga gingivalis were examined in periodontally healthy and periodontitis subjects, both with and without type 1 diabetes (n = 60). serum igg responses to ceps were determined by immunoblotting with biotin-goat anti-human igg and an alkaline phosphatase-streptavidin system. reactivity was analyzed by transmission densitometry, digitization, and computer manipulation. the ...19979390475
characterization of protease activities in capnocytophaga spp., porphyromonas gingivalis, prevotella spp., treponema denticola and actinobacillus actinomycetemcomitans.protease activities in cell sonicates of defined bacterial strains were examined using peptide substrates and class-specific inhibitors. capnocytophaga spp. all produced serine dipeptidyl peptidase activity and arginine/lysine, elastase- and chymotrypsin-like enzymes with some metalloprotease characteristics. the elastase-like activity was strongest in capnocytophaga sputigena, but the others were greatest in capnocytophaga gingivalis. the latter also had a separate arginine-specific enzyme whic ...19979467394
subgingival distribution of periodontopathic bacteria in adult periodontitis and their susceptibility to minocycline-hcl.the purpose of this study was to investigate the distribution of several periodontopathic bacteria in adult periodontitis, their in vitro susceptibility to minocycline-hcl, and whether the efficacy of the drug changes with a decrease in bacterial susceptibility. twenty-one patients (43 to 75 years old) with 62 periodontal lesions from pockets > or =4 mm participated in the study. after subgingival sampling, an ointment containing 2% minocycline-hcl was applied locally to the selected pockets onc ...19989527568
subgingival microflora associated with nifedipine-induced gingival overgrowth.the purpose of this study was to examine the composition of subgingival plaque of 140 periodontal lesions in 35 patients with cardiovascular disorders who were administered nifedipine and manifested nifedipine-induced gingival overgrowth (go). age was inversely associated with the go. plaque index and bleeding index showed a significant association with go, while nifedipine dosage and duration of nifedipine therapy were not found to be significant predictors of go. the gingival inflammation as e ...19989660335
subgingival microflora and treatment in prepubertal periodontitis associated with chronic idiopathic neutropenia.prepubertal periodontitis affects both primary and permanent dentition. the purpose of this study was to examine the composition of subgingival microflora of the permanent dentition in an 11-year-old caucasian female, who had premature exfoliation of her deciduous teeth on her 5th year of age, and the response of this condition to the antibiotic therapy and supportive periodontal care. gingival tissues were highly inflamed and alveolar bone loss was detected radiographically. the girl had experi ...19989763332
detection of dextranase-producing gram-negative oral bacteria.thirty-one strains of 23 gram-negative oral bacterial species were examined for dextran-degrading activity on agar plates containing blue dextran. one strain each of capnocytophaga ochracea, capnocytophaga sputigena, prevotella loescheii, prevotella melaninogenica and prevotella oralis had detectable dextranase activity. the culture supernatants of p. melaninogenica and p. oralis cells contained dextranases of multiple sizes, but those of the other three species had a single size of enzyme. a 56 ...19989872116
chorioamnionitis with intact membranes caused by capnocytophaga sputigena.we report a case of chorioamnionitis with intact membranes caused by capnocytophaga sputigena. the pregnant woman was hospitalised in preterm labor without fever, neither tenderness, just regular contractions. in spite of the tocolitic treatment the patient gave birth to a girl at 29 weeks' gestation, weighing 1220 g and transferred to intensive care. the newborn had clinical and biological signs of infections and was initially treated by ampicillin, cephalosporin and metronidazol. capnocytophag ...199910221619
second-trimester abortion caused by capnocytophaga sputigena: case report.intra-amniotic infection is often the cause of a second-trimester abortion. the bacterial species involved include bacteria with low pathogenicity like ureaplasma urealyticum and various mycoplasma species. in this case we describe an intra-amniotic infection caused by capnocytophaga sputigena, often found in the normal bacterial flora of the oral cavity, but not in the vagina. oral sex during pregnancy was the most probable source of the infection. the aborted fetus showed signs of pneumonia up ...199910458530
microbiology of subgingival plaque from children with localized prepubertal periodontitis.localized prepubertal periodontitis has been described as a host-defect mediated form of bacterially induced periodontitis, with an early onset and rapid progression around a few teeth in children prior to puberty. to further our understanding of the etiology of this disease, we have examined the microbiological components of subgingival dental plaque in 9 children with localized prepubertal periodontitis to determine if patterns of putative pathogens existed, and have compared these results wit ...198710870471
characterization and cross-reactivity of rabbit antisera to plaque toxins.the effects of heat labile, high molecular weight water-soluble toxins from bacterial plaque on hl60 promyelocytic cells were examined. on gel filtration, four inhibitors of hl60 cell growth and two inhibitors of hela cell growth (pt1, pt2) were detected. the first and third hl60 cell inhibitors corresponded to the two hela cell inhibitors. the last eluted hl60 cell inhibitor (plaque leukotoxin, pl) did not inhibit hela cell growth. anti-pt2 antibodies reduced the activity of enriched pt2 by 20- ...198710870474
early microbial colonization of permucosal implants in edentulous patients.in edentulous patients, the microbial colonization of permucosal implants of sintered hydroxyapatite was studied. samples were taken from mucosa and dentures before insertion of implants and from supra- and subgingival sites two to 10 weeks after insertion. in total, five patients and 10 implants with clinically healthy peri-implant tissues were studied. the samples were investigated by dark-field microscopy and anaerobic culture. the supragingival plaque of the implants was dominated by gram-po ...198710872401
microbial composition of supra- and subgingival plaque in subjects with adult periodontitis.the purpose of the present study was to compare and relate the microbial composition of supra and subgingival plaque in 23 adult periodontitis subjects (mean age 51 +/- 14 years).200011034118
pcr detection of capnocytophaga species in dental plaque samples from children aged 2 to 12 years.the purpose of this study was to detect the presence of capnocytophaga sputigena, c. ochracea, and c. gingivalis in plaque samples from the toothbrushes of 122 children, using a polymerase chain reaction (pcr) method. the subjects were 25, 85, and 12 children with healthy gingiva, gingivitis, and periodontitis, respectively, ranging in age from 2-12 years old. plaque samples were collected from all erupted tooth sites using a sterile toothbrush. the mean amount of dna recovered from the samples ...200111270602
relationship of periodontopathic bacteria with early-onset periodontitis in down's syndrome.down's syndrome (ds) patients often develop severe early-onset marginal periodontitis in early adulthood; however, there is little information available on the microbiology of ds periodontitis.200111327065
[utility of prolonged incubation and terminal subcultures of blood cultures from immunocompromised patients].the value of blind terminal subcultures (7 and 30 days) and prolonged incubation (30 days) of blood cultures from immunosuppressed patients was analyzed in the fundación favaloro, the fundación para la lucha contra las enfermedades neurológicas de la infancia and the hospital de niños ricardo gutiérrez. a total of 2707 blood cultures and 369 patients were included (transplantation of solid organs 154, oncohematologic disorders 106 and solid tumors 109). bact-alert bottles were incubated at 35 de ...200111594009
periodontopathic bacterial infection in childhood.little information is available on periodontopathic bacterial infection in childhood. we assessed the prevalence by age of 10 putative periodontopathic microorganisms in periodontally healthy children using a polymerase chain reaction (pcr) assay.200211846195
[in vitro sensitivity of oral gram-negative bacteria to the bactericidal activity of defensins].oral gram-negative bacteria, including actinobacillus actinomycetemcomitans, porphyromonas gingivalis, capnocytophaga sputigena, provotella intermedius, provotella melaninogenicus, have been associated with destructive periodontal infection. an ultrasensitive antibacterial assay was applied to determine the sensitivity of a battery of oral gram-negative bacteria to the bactericidal effects of the isolated human neutrophil defensins (hnp) and two kinds of rabbit defensins np1 and np2. all species ...199812078176
mixed bacteremia with capnocytophaga sputigena and escherichia coli following bone marrow transplantation: case report and review. 200414712364
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