Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| continuous subcutaneous insulin infusion versus injection therapy: a randomized cross-over trial under usual diabetic clinic conditions. | twelve c-peptide negative insulin-dependent diabetic patients participated in a randomized cross-over study of 6 months treatment with twice or thrice daily insulin injection therapy and continuous subcutaneous insulin infusion (csii). standard, non-intensified management conditions were maintained throughout. glycosylated haemoglobin levels were similar on both regimens (9.2 +/- 0.5% versus 9.0 +/- 0.4%; csii vs injection therapy; (mean +/- sem). capillary blood glucose concentrations before br ... | 2010 | 2962807 |
| new data on the acceptance of the hepatitis b vaccine by dental personnel in the united kingdom. | 2010 | 2964251 | |
| a stable tracer technique for calcium metabolism studies. | a tracer technique using the stable isotope calcium-48 was developed to facilitate studies of human calcium metabolism. small samples of 1 ml serum were used. calcium levels were determined with good precision using neutron-activation analysis after pre-concentration of the serum calcium by oxalate precipitation. the method has sufficient sensitivity to detect induced dilutions of the tracer by administering other less costly isotopes of calcium. the ability to utilize small volumes of sample is ... | 1988 | 2980818 |
| alterations in concentrations of cyclic guanosine 3',5'-monophosphate in guinea pig urine during the development of a transplantable leukaemia. | cyclic guanosine 3',5'-monophosphate (cgmp) concentrations were measured in urine specimens from guinea pigs before and after transplantation of a leukemia. a transient increase in cgmp concentration occurred 3 days after inoculation which preceded any detectable increase in the white blood cell count. this peak in cgmp concentration was found to be very highly significant when compared with fluctuations in urinary cgmp levels in the guinea pigs from transplantation of the leukemia. inoculation ... | 1985 | 2992765 |
| antinociceptive effect of diisopropylphosphofluoridate: development of tolerance and lack of cross-tolerance to morphine. | the irreversible cholinesterase inhibitor diisopropylphosphofluoridate (dfp) causes a naloxone-sensitive antinociceptive effect in laboratory animals. chronic treatment of male mice with dfp (2 mg/kg/day for fourteen days) rendered the animals tolerant to its antinociceptive effect. animals tolerant to dfp were cross-tolerant to the antinociception induced by the cholinergic agonists oxotremorine and nicotine, but no cross-tolerance with morphine was observed. similarly, mice made tolerant to mo ... | 2010 | 2993935 |
| polarized plasma membrane domains in cultured endothelial cells. | to determine whether distinct plasma membrane domains exist in endothelial cells, we infected monolayer cultures of macro- and microvascular endothelial cells with enveloped rna viruses known to bud selectively from either the apical or basal surface in polarized epithelial cells. we found that vesicular stomatitis (vsv) and sendai virus emerge asymmetrically from cultured endothelial cells. this provides direct evidence for the existence of polarized plasma membrane domains in vascular endothel ... | 1985 | 2996916 |
| [surgery in the treatment of patients with small cell lung cancer]. | the data on surgical and combined treatment of 52 cases of small cell lung cancer are presented and the end results are evaluated. the findings on survival time make the case for surgery as a component of combined treatment of tumor. the best results were obtained in cases of stage i and ii tumor, absence of metastases into intrathoracic lymph nodes, tumor invasion limited to bronchopulmonary lymph nodes or the root of the lung, intermediate cell pattern of small cell lung cancer and surgery fol ... | 2010 | 2998088 |
| demonstration of non-degraded aleutian disease virus (adv) proteins in lung tissue from experimentally infected mink kits. brief report. | isolates of adv replicate to rather high quantities in lungs from neonatally infected mink kits. the virus was analysed for polypeptide composition, and for the first time high molecular weight polypeptides have been observed in in vivo produced advs. these polypeptides are analogous to those of in vitro produced advs. the molecular weights of the structural polypeptides of the low virulence pullman adv and the highly virulent dk and utah i isolates of adv were found to be 88kd and 78kd and in v ... | 1986 | 3002299 |
| effect of dibutyryl cyclic amp on morphologic features and biologic markers of a human salivary gland adenocarcinoma cell line in culture. | dibutyryl cyclic amp (db-camp) has marked effects on the growth, morphologic features, and biologic markers of a human salivary gland adenocarcinoma cell line in culture. a cell line with ultrastructure and biologic markers specific to the intercalated duct cells of human salivary glands was cultivated in the presence of db-camp. major alterations, such as process formation and expression of myofilaments and oxytocin receptor in addition to myosin and s-100 protein, were observed in those cells ... | 1986 | 3002591 |
| central nervous system lesions in suckling mice and rats inoculated intranasally with sialodacryoadenitis virus. | suckling cd-1 and cfw mice and wi wistar rats were inoculated intranasally with sialodacryoadenitis virus. in animals inoculated during the first week of life, there was an acute necrotizing encephalitis with malacia and minimal inflammatory cell response. in mice and rats which survived for up to 12 days post inoculation, loss of brain substance, gitter cells and occasionally mineralized debris were seen. viral antigen was readily demonstrated in neurons and nasal epithelium in trypsin-treated, ... | 1986 | 3004003 |
| significance of intracellular calcium and cyclic adenosine 3',5'-monophosphate in the mechanisms by which prostaglandins influence human sperm function. | the selective ability of pge-1 and pge-2 to enhance the capacity of human spermatozoa for hamster oocyte penetration was dependent upon high concentrations (1.7 mm) of extracellular ca2+ and a prolonged (4 h) duration of exposure, and insensitive to the ca2+ channel antagonist, verapamil. studies with the intracellular calcium indicator quin-2 indicated that exposure to pge-1 and pge-2, but not pgf-2 alpha, induced a significant rise in the levels of cytoplasmic ca2+, suggesting that an ionophor ... | 1986 | 3016256 |
| epstein-barr virus infections in families: the role of children with infectious mononucleosis. | we performed a prospective evaluation of epstein-barr virus (ebv) infections in 78 families with a childhood index case of ebv-infectious mononucleosis (ebv-im). during the acute index episode, adult family (household) contacts, compared with control adults, had a greater rate of oropharyngeal ebv excretion and high serum antibody responses, which suggested a recent antecedent reactivation of an old ebv infection. the increased prevalence of oropharyngeal ebv and acute serological responses foun ... | 1986 | 3021867 |
| release of low infectivity vesicular stomatitis virus particles from tunicamycin-treated cells. | the effect of tunicamycin (tm) treatment on the production, glycosylation, morphology and infectivity of vesicular stomatitis virus (vsv) released from mouse (lb), monkey (cos-1 and vero), bovine (mdbk), hamster (bhk) and human (hela, u and gm2504) cells was investigated. the yield of vsv particles released from tm treated cells, as measured by total viral proteins, was inhibited only 2-10 fold while the infectivity of these particles was greatly reduced (10-1000 fold). the morphology of vsv par ... | 1985 | 3023584 |
| hypophosphatemic rickets/osteomalacia in linear sebaceous nevus syndrome: a variant of tumor-induced osteomalacia. | a severe form of vitamin d-resistant rickets is associated with the linear sebaceous nevus syndrome. we investigated the pathophysiology underlying defective bone mineralization in two individuals and examined the effects of 1,25-dihydroxyvitamin d (1,25(oh)2d, calcitriol) therapy on the clinical and biochemical abnormalities. both patients had fasting hypophosphatemia, markedly diminished tmp/gfr, and elevated alkaline phosphase activity in the presence of normocalcemia. before treatment with c ... | 2010 | 3023599 |
| interactions of anticancer quinone drugs, aclacinomycin a, adriamycin, carbazilquinone, and mitomycin c, with nadph-cytochrome p-450 reductase, xanthine oxidase and oxygen. | the properties of the interactions of anticancer quinone drugs, aclacinomycin a, adriamycin, carbazilquinone, and mitomycin c with nicotinamide adenine dinucleotide phosphate (nadph)-cytochrome p-450 reductase and xanthine oxidase under anaerobic and aerobic conditions were studied. km values of nadph-cytochrome p-450 reductase for these drugs were in the range of 40-227 microm, and that of deflavo xanthine oxidase in the range of 39-over 200 microm. under anaerobic conditions, when xanthine was ... | 2010 | 3023600 |
| initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. ii. role of segmental swim-initiating interneurons. | cell tr1, a trigger neuron found in the subesophageal ganglion of the leech, hirudo medicinalis, is part of a network of subesophageal ganglion neurons which control swimming activity, and makes apparently direct connections to swim-initiating interneurons (siis; cells 204 and 205). in this study, we investigated the role of siis in swim initiation by cell tr1. we also examined how brief tr1 activity controls swim initiation at the levels of the siis and of the oscillator neurons. we found: in s ... | 1986 | 3023603 |
| initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. iii. sensory inputs to tr1 and tr2. | in papers i and ii of this series, we described two pairs of interneurons, tr1 and tr2, in the leech subesophageal ganglion which can trigger swimming activity in the isolated central nervous system (cns). in this paper, we describe sensory inputs to these trigger neurons from previously identified mechanosensory neurons. we found that: weak mechanical stimulation (stroking) of a body wall flap attached to a segmental ganglion in an otherwise isolated cns excites the contralateral tr1 slightly. ... | 2010 | 3023604 |
| immunosuppressive properties of human placenta: study of supernatants from short-term syncytiotrophoblast cultures. | using collagenase and mechanical treatment to attempt to eliminate cellular contamination such as macrophages and decidual cells, trophoblast enriched cell suspensions were isolated from the human placenta. with a view to assessing the role of trophoblast in impairing maternal rejection of the fetus, supernatants (spl4) were prepared from these placental cells after short-term culture (4 h). the immunosuppressive activity of these supernatants was studied following application to mitogen-stimula ... | 1986 | 3023607 |
| synthesis and antiviral evaluation of 1,4-dioxane nucleoside analogues related to nucleoside dialdehydes. | since biologically active nucleoside 2',3'-dialdehydes exist as six-membered cyclic acetals (1) in solution, we have investigated the antiviral activity of some structurally similar 1,4-dioxane nucleoside analogues. by reacting 2',3'-seconucleoside tosylates with base, the guanine (10) and adenine (18) substituted (hydroxymethyl)dioxanes have been constructed. in addition, an unusual adenine-substituted divinyl ether (22) was synthesized via a base-catalyzed, double elimination of a 2',3'-di-o-t ... | 1986 | 3023613 |
| beta 2 microglobulin enhances the infectivity of cytomegalovirus and when bound to the virus enables class i hla molecules to be used as a virus receptor. | we have previously demonstrated that human cytomegalovirus (cmv) binds the host protein beta 2 microglobulin (beta 2m) from body fluids or from cell culture media. in this report we have examined the effect of the beta 2m on viral infectivity. we have shown that the addition of human purified beta 2m, or a fraction of foetal calf serum corresponding to bovine beta 2m, to culture medium increased the amount of infectious extracellular cmv, compared to that from cells grown in serum-free medium. m ... | 1987 | 3029306 |
| [immunohistological detection of antisera to casein in skin tumors]. | 2010 | 3029469 | |
| [immunohistological detection of antisera to casein in skin tumors]. | 2010 | 3029469 | |
| regional variation in high-density lipoprotein binding to human adipocyte plasma membranes of massively obese subjects. | obesity is associated with significant changes in cholesterol and lipoprotein metabolism. high density lipoprotein (hdl) cholesterol is often reduced and adipose tissue cholesterol stores are increased in obese individuals. this prompted a study on the binding of hld fractions (hdl2 and hdl3) to adipocyte plasma membranes obtained from massively obese subjects (bmi greater than 37 kg m-2) undergoing gastroplasty. regional variation in hdl binding to these adipocyte plasma membranes was demonstra ... | 1987 | 3032643 |
| communicating leveled clinical expectations to nursing students. | nurse educators agree on the need for objectives in the classroom situation and frequently communicate them in a written form. written expectations for clinical, however, are rarely given to student nurses prior to their clinical experience. clinical expectations are understood by instructors, but communicating them to students result in mixed interpretations. the article describes the development of a written method of communicating clinical expectations to solve this problem. this method corre ... | 2010 | 3035139 |
| a high-yield, high-purity elutriation method for preparing human granulocytes demonstrating enhanced experimental lifetimes. | a counterflow centrifugal elutriation procedure for preparing human granulocytes is described. this method permits isolation of 1-2 x 10(9) granulocytes with a yield of 70% +/- 7% from a unit of whole blood in 3 h. these cells are 99% +/- 1% pure and 95-99% viable. when compared to cells prepared by a conventional procedure employing hypotonic lysis to remove red cells, the elutriated cells show enhanced oxidative responses resulting from enhanced longevity. other responses including receptor-me ... | 1987 | 3036986 |
| t and b peripheral blood lymphocytes in normal and lymphocytotic sheep. | surface immunoglobulins (sig), peanut agglutinin (pna), spontaneous erythrocyte rosette (e-rosette) and helix pomatia (hp) marker were investigated in normal and bovine leukemia virus (blv)-infected sheep. in normal sheep, 19.3% +/- 4.9 of peripheral blood lymphocytes (pbl) were sig+, whereas 58% +/- 5.69 were pna+, and 19.6 +/- 5.2 were e-rosette forming cells (e-rfc). in blv-induced lymphocytotic sheep, sig+ cells in pbl reached 59.4% +/- 15.06. in the same animals, pna bound to 20.6% +/- 9.69 ... | 1987 | 3040327 |
| [experiences with the preventive use of aminophylline (euphylline) in apnea and periodic respiration in infants]. | sleep apnea and periodic breathing in infants are the result of a mild hypoxia and they are the requirement for sids. as a results of the modern medicine each 4.-5. death is the cause of sids during the first year of life. the positive effect of theophylline on apnea of prematurity is known since 1973. we have given theophylline (euphyllin) from 1979 till 1986 to 198 premature infants with a birth weight below 2000 g for apnea prophylaxis orally in a doses of 9 mg/kg body weight per day distribu ... | 2011 | 3043316 |
| roles of hormonal and nutritional factors in the regulation of rat liver alcohol dehydrogenase activity and ethanol elimination rate in vivo. | fasting reduced the liver alcohol dehydrogenase (adh) activity by 51% (p less than 0.001). insulin, within 2 hr, increased the adh activity found in fasted animals by 28% (p less than 0.02). insulin administration failed to stimulate the reduced adh activity in diabetic rats. however, adh activity in the diabetic-fed rats decreased by 52-54% (p less than 0.001) compared to normal-fed rats regardless of whether they were meal-fed or refed the normal chow. glucagon blocked by 15% (p less than 0.02 ... | 1988 | 3044171 |
| [trisomy 13 by translocation. possible prenatal ultrasonic diagnosis]. | 1988 | 3057974 | |
| [sound injuries after surgery of otosclerosis]. | surgery for otosclerosis means that the sound protection due to the fixation of the footplate does not exist anymore. as the corti hair cells have been fragilized by proteolytic enzymes, it is absolutely necessary to reconstruct the sound mechanism in order to maintain the vibration of the perilymph absolutely within acoustical physiologic limit of movement. the means to realize this reconstruction are presented in this paper, as well as the results. | 2011 | 3059938 |
| p21-ras effector domain mutants constructed by "cassette" mutagenesis. | a series of mutations encoding single-amino-acid substitutions within the v-rash effector domain were constructed, and the ability of the mutants to induce focal transformation of nih 3t3 cells was studied. the mutations, which spanned codons 32 to 40, were made by a "cassette" mutagenesis technique that involved replacing this portion of the v-rash effector domain with a linker carrying two bspmi sites in opposite orientations. since bspmi cleaves outside its recognition sequence, bspmi digesti ... | 2010 | 3062384 |
| [postoperative disorder of bladder emptying in gynecology: pathophysiology and possibilities for treatment]. | urinary retention after radical hysterectomy is due to partial or complete denervation of the bladder and proximal urethra which is dependent on surgical radicality. in contrast, incomplete bladder emptying after surgery for stress induced urinary incontinence, has its origin in an infravesicular functional obstruction and is dependent on the operation performed. the use of drugs (alpha-sympatholytics, parasympathomimetics) seem to be of limited value, especially after stress-incontinence surger ... | 2010 | 3063586 |
| [postoperative disorder of bladder emptying in gynecology: pathophysiology and possibilities for treatment]. | urinary retention after radical hysterectomy is due to partial or complete denervation of the bladder and proximal urethra which is dependent on surgical radicality. in contrast, incomplete bladder emptying after surgery for stress induced urinary incontinence, has its origin in an infravesicular functional obstruction and is dependent on the operation performed. the use of drugs (alpha-sympatholytics, parasympathomimetics) seem to be of limited value, especially after stress-incontinence surger ... | 2010 | 3063586 |
| [immunologic support for clinical bone marrow transplants]. | 2010 | 3063589 | |
| [immunologic support for clinical bone marrow transplants]. | 2010 | 3063589 | |
| infective endocarditis and antibiotic prophylaxis failure following an endodontic procedure. | 2010 | 3063597 | |
| infective endocarditis and antibiotic prophylaxis failure following an endodontic procedure. | 2010 | 3063597 | |
| [being a fan of delegated matters (aleksandr vasil'evich borisovskiĭ)]. | 2011 | 3064403 | |
| the effects of triclabendazole on the lung fluke, paragonimus uterobilateralis in the experimental host sigmodon hispidus. | the new veterinary drug triclabendazole (fasinex) was tested for its anthelmintic activity against adult paragonimus uterobilateralis in experimentally infected cotton rats, sigmodon hispidus. after a single dose of 50, 100 or 150 mg/kg b.w. triclabendazole or after two doses of 5 or 10 mg/kg b.w. given at an interval of 24 hours, 56-61% of the flukes were dead at three to five weeks after treatment. two doses of 50 or 75 mg/kg b.w. triclabendazole killed all flukes. the flukes, which were still ... | 1988 | 3067323 |
| hpa axis disturbance and treatment outcome in panic disorder. | some patients with panic disorder exhibit an abnormal response to dexamethasone. as this phenomenon may reflect disturbances in the central noradrenergic system and as alprazolam may work through this system to produce improvement, we predicted a particularly robust response among nonsuppressors. fifty-two patients with panic disorder or with agoraphobia with panic attacks were given alprazolam as the sole treatment during either of 2, 8-week, double-blind, placebo-controlled trials. though base ... | 2011 | 3067754 |
| [surgical trauma and the adequacy of the anesthesiologic service]. | 2011 | 3070119 | |
| some properties of lipoxygenase activities in cytosol and microsomal fractions of mouse epidermal homogenate. | lipoxygenase activity in microsomal fraction of mouse epidermal homogenate was characterized in comparison with cytosol lipoxygenase activity. the major activity was identified as 12-lipoxygenase in microsomal fraction as well as in cytosol fraction by the analyses with high-performance liquid chromatography and gas chromatography-mass spectrometry. apparent km values of cytosol and microsomal 12-lipoxygenase for arachidonic acid were 5.0 microm and 6.2 microm respectively. apparent vmax values ... | 1986 | 3085110 |
| some properties of lipoxygenase activities in cytosol and microsomal fractions of mouse epidermal homogenate. | lipoxygenase activity in microsomal fraction of mouse epidermal homogenate was characterized in comparison with cytosol lipoxygenase activity. the major activity was identified as 12-lipoxygenase in microsomal fraction as well as in cytosol fraction by the analyses with high-performance liquid chromatography and gas chromatography-mass spectrometry. apparent km values of cytosol and microsomal 12-lipoxygenase for arachidonic acid were 5.0 microm and 6.2 microm respectively. apparent vmax values ... | 1986 | 3085110 |
| metabolism-related tissue-binding of halogenated hydrocarbons. | 1986 | 3101260 | |
| wellcome developments in tropical medicine. | 2010 | 3105672 | |
| wellcome developments in tropical medicine. | 2010 | 3105672 | |
| early emergency care. | 2010 | 3105703 | |
| early emergency care. | 2010 | 3105703 | |
| prejudice against women doctors. | 2010 | 3105765 | |
| prejudice against women doctors. | 2010 | 3105765 | |
| cerebral perfusion pressure: a hemodynamic mechanism of mannitol and the postmannitol hemogram. | sixteen patients each received infusions of 1 g of mannitol per kg over 5 to 10 minutes, and serial determinations of intracranial pressure (icp), systemic arterial blood pressure (sabp), central venous pressure, cerebral perfusion pressure (cpp), hematocrit, hemoglobin, serum na+, k+, osmolarity, and fluid balance were carried out for 4 hours. urine output was replaced volume for volume with 5% dextrose in 0.45% nacl solution. we tested the hypothesis that patients with high (greater than or eq ... | 2010 | 3116451 |
| effect of local vibration on ventilatory response to hypercapnia in normal subjects. | we studied the effects of local high frequency mechanical vibration on ventilatory (ve) and occlusion pressure (p0.1) responses to co2 rebreathing in twelve normal subjects. three kinds of vibration procedures were employed: a) sustained vibration over the tendon of the quadriceps femoris near the knee, b) sustained vibration of the right 2nd or 3rd parasternal intercostal spaces and c) 'in-phase' chest wall vibration applied during inspiration on the right 2nd or 3rd parasternal intercostal spa ... | 2010 | 3117148 |
| chemotherapy of pulmonary tuberculosis in britain. | 1988 | 3123192 | |
| hyponatremia and schizophrenia: a case presentation. | 2011 | 3126424 | |
| follicle-stimulating hormone induces deoxyribonucleic acid polymerase alpha before deoxyribonucleic acid synthesis in immature rat ovarian follicles perfused in vitro. | to examine the effects of follicle-stimulating hormone (fsh) on cell proliferation and cell division in ovaries, deoxyribonucleic acid (dna) polymerase activities and dna concentrations were determined in ovarian follicles of immature, hypophysectomized, estradiol-treated rats perfused in vitro. ovine fsh (2-20 micrograms/ml) significantly enhanced the dna polymerase alpha activity in the follicles perfused for 180-300 minutes, whereas the dna polymerase beta activity and dna concentration showe ... | 1988 | 3126468 |
| serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin b1 intake and urinary excretion of aflatoxin m1. | aflatoxin-serum albumin adducts in the blood of 42 residents of guangxi province, people's republic of china, were determined and compared with intake of aflatoxin b1 (afb1) and excretion of aflatoxin m1 (afm1) in urine. blood specimens were obtained during the same period that urine was collected and that diet was sampled. serum albumin was isolated from blood by affinity chromatography on reactive blue 2-sepharose and subjected to enzymatic proteolysis using pronase. immunoreactive products we ... | 1988 | 3133131 |
| intravenous immune globulin in symptomatic paediatric human immunodeficiency virus infection. | seven paediatric patients with symptomatic human immunodeficiency virus (hiv) infection were prospectively studied for 6-24 months after the start of intravenous immune globulin (ivig) therapy. there was substantial clinical benefit during ivig treatment with marked reduction of febrile and infectious episodes, normalization of physical and psychomotor development, and absence of mortality. the immunologic monitoring revealed some discrete objective improvements. the results of this study favour ... | 1988 | 3134244 |
| bile acid synthesis in man. in vivo activity of the 25-hydroxylation pathway. | during biosynthesis of bile acid, carbons 25-26-27 are removed from the cholesterol side-chain. side-chain oxidation begins either with hydroxylation at the 26-position, in which case the three-carbon fragment is released as propionic acid, or with hydroxylation at the 25-position, in which case the three-carbon fragment is released as acetone. we have previously shown in the rat that the contribution of the 25-hydroxylation pathway can be quantitated in vivo by measuring production of [14c]acet ... | 1988 | 3134400 |
| veterinary medicines in animal foods. | 2011 | 3145058 | |
| damp housing and childhood asthma: validation of reporting of symptoms. | the relations among parental reports of respiratory symptoms, bronchospasm measured after exercise, and the presence of visible fungal mould in the home was assessed in a population sample of 7 year old children (n = 873). wheeze in the past year was the symptom most closely associated with reported dampness and particularly with mould. the unadjusted odds ratio relating mould and wheeze was 3.70 (95% confidence interval 2.22 to 6.15), and after adjustment for housing tenure, number of people pe ... | 2011 | 3145060 |
| smokeless tobacco control. report of a who study group. | 1988 | 3145646 | |
| a controlled trial of gamma-vinyl-gaba (vigabatrin) in drug-resistant epilepsy. | 2011 | 3145776 | |
| intercalary heterochromatin in drosophila. iii. homology between dna sequences from the y chromosome, bases of polytene chromosome limbs, and chromosome 4 of d. melanogaster. | molecular and cytogenetic characteristics are given of a 2846 bp dna sequence from the ydm12 clone, previously derived from the long arm of the drosophila melanogaster y chromosome. sequence analysis revealed within it a 1176 bp fragment with 37 bp terminal inverted repeats, flanked by 6 bp direct repeats. this fragment (called "element 1360") appeared to be a-t rich, and was saturated with short direct and inverted repeats of different degrees of homology and consensus sequences for transcripti ... | 2011 | 3146482 |
| effects of maternal exposure to polychlorobiphenyls (pcbs) on f1 generation behavior in the rat. | the effect of fenclor 42 (pcb) exposure of female rats (fischer 344 strain) was studied through assessment of the behavioral development of their f1 progeny. female rats were exposed to pcb according to the following treatment schedule: (a) (5 days) 2 weeks prior to mating, (b) during gestation (days 6-15 of pregnancy), (c) during lactation (days 1-21 after delivery). behavioral endpoints of motor reflexes, motor coordination, activity (preweaning behaviors), and learning (postweaning behavior) ... | 1988 | 3146520 |
| evaluation of the quality of bacteriologic methods used to diagnose tuberculosis in argentina. | 1988 | 3147118 | |
| clonidine hyperphagia: neuroanatomic substrates and specific function. | recent studies have indicated that the alpha 2-noradrenergic agonist clonidine (clon), when peripherally and centrally administered, potentiates feeding in satiated rats in a manner similar to that observed following injection of norepinephrine (ne) into the hypothalamic paraventricular nucleus (pvn). the present experiments examined the effects of clon on meal patterns and macronutrient selection and compared these findings to earlier ne-stimulated feeding studies. administration of clon (25 nm ... | 1988 | 3147461 |
| the physiology and pathophysiology of eicosanoids in the skin. | eicosanoids may play a role in the pathophysiology of common inflammatory skin diseases such as psoriasis and atopic eczema. their involvement offers the hope for development of new antiinflammatory drugs for use in dermatopharmacology. on the other hand, new findings also suggest a tissue protective role of prostanoids in skin. in addition, physiological functions of lipoxygenase-derived eicosanoids are emerging, which may serve to maintain cutaneous integrity and restore normal skin structure ... | 2010 | 3152488 |
| distribution of sensory receptors in the flexor carpi radialis muscle of the cat. | the structures and distribution of encapsulated muscle receptors were examined in serial transverse sections of flexor carpi radialis in the adult cat. four types of receptors (muscle spindles, golgi tendon organs, paciniform, and pacinian corpuscles) were identified. their structures resembled those encountered in other limb muscles. pacinian corpuscles were rare and occurred only in the external fascial coat of the muscle near its origin. the other three receptor types were distributed in an u ... | 1985 | 3156250 |
| characterization of protein kinase c and its role in catecholamine secretion from bovine adrenal-medullary cells. | protein kinase c activity towards exogenous histone was detected in a cytosolic fraction of bovine adrenal medulla. the enzyme was dependent on ca2+ and phosphatidylserine for its activity, with half-maximal activation being achieved at approx. 18 microm free ca2+ and 8 micrograms of phosphatidylserine/ml. both diolein and 4 beta-phorbol 12-myristate 13-acetate (tpa) decreased the ca2+ requirement of the enzyme, half-maximal activation being obtained at approx. 12 microm and 9 microm free ca2+ r ... | 1985 | 3159383 |
| ileal ph in cystic fibrosis. | in cystic fibrosis jejunal hyperacidity has an adverse effect on lipid digestion. it is not known whether hyperacidity extends to the ileum. we have studied ph through the whole length of the small bowel in 42 normal and 6 cystic fibrosis subjects by means of ph-sensitive radiotelemetry capsules. in cystic fibrosis subjects the time spent below ph 6.0 was significantly greater during the 1st h in the small bowel than in normal subjects. in the rest of the small bowel the ph remained above 6.0 in ... | 2011 | 3164499 |
| [complications of retinoid treatment in children]. | 2011 | 3165253 | |
| structure of the human liver/bone/kidney alkaline phosphatase gene. | in man, there are multiple forms of alkaline phosphatase encoded by at least three homologous genes: placental, intestinal, and liver/bone/kidney. this report describes the characterization of the human liver/bone/kidney alkaline phosphatase locus. the gene appears to exist as a single copy in the haploid genome and is comprised of 12 exons distributed over more than 50 kilobases. in liver, kidney, saos-2 human osteosarcoma cells, and cultured fibroblasts, there is a single major start for trans ... | 1988 | 3165380 |
| needle aspiration of nonperitonsillar head and neck abscesses. a six-year experience. | twenty-five patients with various head and neck abscesses have been managed with needle aspiration as the initial surgical modality over a six-year period. twenty (83%) of 24 patients' abscesses resolved without formal surgical intervention. patient 25 in the series whose abscess, though initially resolving, reaccumulated within two weeks requiring an incision and drainage. recurrent cancer was then diagnosed. eight of ten large-volume abscesses (over 10 ml) were controlled with needle aspiratio ... | 2011 | 3166766 |
| organized nursing declares zero tolerance for rct. | 2011 | 3167923 | |
| characterization of radiation resistant hypoxic cell subpopulations in kht sarcomas. (ii). cell sorting. | hypoxic cells in kht sarcomas were characterized using fluorescence activated cell sorting based on the diffusion properties of the fluorochrome hoechst 33342. tumour-bearing female c3h/hej mice were injected i.v. with 10 micrograms g-1 hoechst 33342 and the cells derived from the tumours sorted on the basis of their staining intensities. for each sorted fraction the dna histogram was evaluated using fcm analysis. the results indicated that the bright and dim cells were not equally distributed a ... | 2011 | 3179180 |
| [metabolic criteria of viability of isolated cardiomyocytes]. | 1988 | 3179764 | |
| [metabolic criteria of viability of isolated cardiomyocytes]. | 1988 | 3179764 | |
| subendocardial and subepicardial wall thickening during ischemia in exercising dogs. | to determine whether ischemia in the exercising dog is associated with preservation of subepicardial thickening relative to subendocardial thickening, 10 dogs were chronically instrumented with circumflex artery flow probes, hydraulic occluders, and pairs of ultrasonic microcrystals for determination of wall thickness in the circumflex artery distribution. one pair of crystals spanned the entire ventricular wall (transmural), and the other spanned the outer half of the ventricular wall. inner wa ... | 1988 | 3180383 |
| [what happens to gallstone fragments? what clears the gallbladder after nonsurgical treatment of gallstones?]. | 2011 | 3181010 | |
| [liver involvement in hodgkin's disease. histopathological study with clinico-biochemical correlation]. | 2011 | 3187122 | |
| determination of u in human tissues by delayed neutron activation analysis. | a rapid, sensitive and highly selective technique using delayed neutron activation analysis (dnaa) has been used to determine u concentrations in human tissues. two different sample preparation techniques were compared: one involves total matrix destruction to a dry ash while the other is a nondestructive preparation of the wet sample. the data obtained from the analyses of the same sample by dnaa of wet tissues, dnaa of ashed tissues and from radiochemical analyses using alpha spectroscopy (a s ... | 1988 | 3198401 |
| food allergy. | 2011 | 3202279 | |
| penetration of nadolol into aqueous humour after a single oral dose. | nadolol 20 mg was administered orally as a single-blind, single dose to nine patients about to undergo cataract extraction. intraocular pressures fell by a mean of 24% 3 h after administration. during the operation, aqueous humour and serum samples were taken for measurement of nadolol concentrations. aqueous nadolol concentrations ranged from 3.8 to 13.4 ng ml-1, and correlated with the serum drug concentrations (r = 0.84). the fall in intraocular pressure did not correlate with either the aque ... | 2011 | 3203065 |
| [a case of cystic changes in a giant leiomyoblastoma of the stomach]. | a 44-year-old male was admitted to hospital with a complaint of abdominal distention. a ct scan revealed a giant multicystic mass in the abdominal cavity, a tumor that measured 34 cm in diameter, which had risen from the gastric body and grew in an exophytic fashion with a stalk. histologic findings exhibited a malignant leiomyoblastoma with cellular pleomorphism and a intracytoplasmic cystic change, which included disseminated nests of immature small round cells. after excisional surgery, the p ... | 2011 | 3204665 |
| synthesis of some derivatives of 1-ethyl-6-fluoro-1,4-dihydro-4-oxo-7-(piperazin-1-yl)-3-quino linecarbo xylic acid (norfloxacin) as potential antibacterial agents. | twelve new fluoroquinolones, structurally related to norfloxacin, have been synthesized in order to investigate the effect of substituents at the secondary nitrogen of the piperazine ring on antimicrobial activity. the new substances (carbamates, isoureas, guanidines, ureas and cyanamides) tested on a variety of gram-positive and gram-negative organisms showed lower activity than the model compound. | 2011 | 3208891 |
| [scanning electron microscopy findings in brand new silicon posterior chamber lenses and those folded for implantation]. | 2011 | 3209155 | |
| protein-related differences in the excretion of nitrosoproline and nitrate by the rat--possible modification of de novo nitrate synthesis. | male ola:sd rats were fed purified diets containing 5 or 20% lactalbumin as the source of protein, and the daily urinary excretion of nitrate and nitrosoproline was measured. animals fed the high-protein diet consistently excreted more nitrate and nitrosoproline than littermates fed the low-protein ration, despite a similar, negligible amount of nitrate in both diets. furthermore, whereas nitrite administration enhanced nitrosoproline excretion in both diet groups, nitrate administration increas ... | 1988 | 3220325 |
| phosphorus-31 nuclear magnetic resonance spectroscopic study of the canine pancreas: applications to acute alcoholic pancreatitis. | the first nuclear magnetic resonance spectroscopic study of the canine pancreas is described. both in-vivo, ex-vivo protocols and nmr observables are discussed. the stability of the ex-vivo preparation based on the nmr observables is established for at least four hours. the spectra obtained from the in-vivo and ex-vivo preparations exhibited similar metabolite ratios, further validating the model. metabolite levels were unchanged by a 50% increase in perfusion rate. only trace amounts of phospho ... | 1988 | 3223430 |
| influence of 1-dodecylhexahydro-2h-azepin-2-one (azone) on the in vitro permeation of verapamil hydrochloride across rat, hairless mouse, and human cadaver skin. | the effect of 1-dodecylhexahydro-2h-azepine-2-one (azone; laurocapran; 1) on the permeation of verapamil hydrochloride (2) through rat skin was studied. compound 1 was used in various concentrations in the donor phase. the permeation of the drug increased significantly in the presence of 1 and the enhancement in permeation was dependent on the concentration of 1. a comparison of the enhancing effect of 3% 1 on permeation of 2 through rat, hairless mouse, and human cadaver skin was made. compound ... | 1988 | 3225773 |
| [assessment of the functional potentials of the body in adapting to different altitudes]. | 2011 | 3227675 | |
| recovery following acute obstruction of the retinal and choroidal circulations. a case history. | the authors report a 70-year-old man who presented with a combined obstruction of both the central retinal artery and the lateral posterior ciliary artery that spontaneously reperfused after 4 days of documented ischemia. despite this prolonged period of decreased perfusion, visual acuity improved from light perception to 20/30 with the re-establishment of normal retinal and choroidal blood flow as documented with intravenous fluorescein angiography. the theory of retinal tolerance time to obstr ... | 1988 | 3231917 |
| [fine needle biopsy of the pancreas with computerized tomography control]. | the results of 96 computed tomography guided percutaneous pancreatic aspiration biopsies were reviewed and compared with the findings at laparotomy or autopsy or with a follow-up of at least one year. in only four instances the follow-up was inadequate and in 29 cases the specimen did not allow a cytologic or histologic diagnosis. of the remaining 67 biopsies 65 were diagnosed correctly and only 2 incorrectly. this corresponds to a sensitivity of 67.7% and a specificity of 97%. in patients with ... | 2011 | 3232439 |
| epithelium-dependent relaxation of guinea-pig tracheal smooth muscle by carbachol. | modulation of the effect of carbachol by epithelium on tracheal smooth muscle of guinea-pig was studied by using coaxial bioassay system. the contractile response of the bioassay organ (epithelium-free tracheal smooth muscle of guinea-pig) to carbachol was well maintained along the observation period of 30 min. when the same bioassay organ was taken into epithelium-intact tracheal tube of guinea-pig, a significant relaxation followed the carbachol-induced initial contraction within 30 min which ... | 1988 | 3233050 |
| comparison of methods of carbamazepine dosage, individualization in epileptic patients. | the aim of the present work was to analyse the predictive capacity of different optimization methods for carbamazepine dosage regimens according to population pharmacokinetic parameters and/or serum levels data. calculations were performed using a multiple non-linear regression program (multi 2 bayes) with two different options: (a) using the ordinary least squares methods and (b) the least squares method based on the bayesian algorithm. the predictive capacity of the three methods was analysed ... | 2011 | 3235481 |
| comparison of methods of carbamazepine dosage, individualization in epileptic patients. | the aim of the present work was to analyse the predictive capacity of different optimization methods for carbamazepine dosage regimens according to population pharmacokinetic parameters and/or serum levels data. calculations were performed using a multiple non-linear regression program (multi 2 bayes) with two different options: (a) using the ordinary least squares methods and (b) the least squares method based on the bayesian algorithm. the predictive capacity of the three methods was analysed ... | 2011 | 3235481 |
| [lipoidosis of the glomerular mesangium with accumulation of cholesterol. a novel hereditary disease]. | a new hereditary disease, transmitted autosomal-dominant, which affects the kidneys has been observed in four members of the same family, three males and a woman. no specific clinical manifestations of the disease have been established. a slight proteinuria was first revealed at the age of 17 years. after about twenty years of moderate proteinuria and microscopic hematuria terminal renal failure and severe arterial hypertension occur. specific for the disease is the storage of lipids, mainly cho ... | 2011 | 3237300 |
| [clinical evaluation of bi-axial pendulum irradiation and pelvic structure tolerance in radiation therapy of carcinoma of the uterine cervix]. | 2011 | 3237468 | |
| competitive direct enzyme-linked immunosorbent assay for detection of sulfamethazine residues in swine urine and muscle tissue. | a sensitive assay for the detection of sulfamethazine in swine urine and muscle tissue using a direct competitive enzyme-linked immunosorbent assay (elisa) has been developed. undiluted urine or a phosphate-buffered saline extract of pork muscle tissue is mixed with an enzyme-labeled conjugate of sulfamethazine and horseradish peroxidase. the mixture is added to wells of a microtiter plate coated with antibody to sulfamethazine. after the test system is incubated, washed, and re-incubated with s ... | 1988 | 3240969 |
| geometric austin osteotomy. | hallux valgus correction utilizing first metatarsal osteotomies is briefly reviewed by the author. a modification of the austin "v" procedure is presented, using basic geometric principles. five patients are reported with successful results. | 2012 | 3243960 |
| postnatal brain growth and allometry in the rabbit oryctolagus cuniculus. | a new four-parameter version of pütter's growth curve (pütter, 1920) recently developed by jolicoeur and pirlot (1988) is applied to cross-sectional data on brain and body weight in 66 male rabbits (oryctolagus cuniculus) ranging up to one year in postnatal age. apart from the olfactory bulb, in which there appears to be no initial delay, the estimated initial delays range from 21.7 days (after fertilization) for the cerebellum to 29.9 days for the cerebrum, which suggests that the weight of mos ... | 1988 | 3255724 |