Publications

assay for nanogram quantities of dna in cellular homogenates.		1979	87138
bleomycin.	bleomycin was approved by the food and drug administration in 1975 for therapy against squamous cell carcinomas, testicular cancers, and malignant lymphomas. an extensive bibliography on this drug indicates that there is little evidence of activity against other malignancies. although initially used exclusively as a single agent, bleomycin has been considered recently for use in combination chemotherapy. because of associated toxicity involving the lung and mucous membranes, bleomycin should be ...	2000	87142
[role of electron microscopy in peripheral nerve pathology (author's transl)].		2000	87154
reinforcing stimulation of the postero-lateral hypothalamus and mating behaviour in the rat.	male rats implanted with chronic electrodes into the postero-lateral hypothalamic site were tested for self-stimulation behaviour. rats exhibiting steady self-stimulation behaviour were observed during mating tests with an oestrus female. during these tests the hypothalamus of male rats was stimulated. results show that no stimulus-bound sexual behaviour was observed. nevertheless, correlations were found between the rewarding value of the cerebral stimulation and the specific sexual components ...	1978	87181
the nursing care and management of coronary artery grafts (revised).		2000	87189
identification of a new basement membrane collagen by the aid of a large fragment resistant to bacterial collagenase.		2000	87347
the production of hydroxyl radical by tallysomycin and copper(ii).		2000	87348
similarity of casein- and endotoxin-induced, myeloma- associated and aged sjl/j amyloid in various strains of mice.	amyloidosis was induced in a number of strains of mice by repeated injections of casein and endotoxin. spontaneous amyloid was obtained from balb/c mice bearing a myeloma tumor (igg2a producing mopc 173 tumor) and from aged sjl/j mice. both the induced and spontaneous forms were similar in their size, immunological reactivity, peptide maps and in the susceptibility of histological sections to oxidizing agents with or without trypsin digestion. since case-induced murine amyloid resembles the noni ...	1979	87374
correction of fallot's tetralogy after palliative operations.	during the period 1960 to 1978, 98 patients underwent intracardiac repair of fallot's tetralogy after palliative operations. preoperative symptoms were cyanosis, dyspnea, increased fatigue with squatting and hypoxic spells. the hemoglobin concentration varied from 19 to 22 g/100 ml. at correction only 65 of 95 shunts were patent and needed surgical closure. seventeen early deaths occurred (19%), the main causes being cardiac failure and arrhythmia. one patient died 3 years after correction from ...	2000	87399
moloney virus-induced cell surface antigens and histocompatibility antigens are located on distinct molecules.		1979	87439
inhibition of antibody production in plasmacytoma cells. iii. interactions of suppressive and nonsuppressive dnp conjugates with mopc 315 cells.		2000	87442
pattern and flash visual evoked responses in multiple sclerosis.	in multiple sclerosis (ms), increase of delay may be important, but the earlier change is the behavior of the wave shape; amplitude is always lower even in ms patients without visual subjective symptomatology, provided not only flash but also pattern stimulation is performed. normal amplitude with pattern stimulation does not necessarily mean normal with flash. combining both stimulation methods, we obtained lowering of amplitude and change of wave shape in 100% of cases while latency was increa ...	2000	87495
query necessity, cost-effectiveness of ivp to evaluate prostatism.		2000	87523
[nursing report. programs for clinical training of adult nursing (surgical nursing)].		2000	87545
homocystinuria and oral contraceptives.		2000	87596
two-week postnatal examination of infants.		2000	87641
oestrogen therapy and endometrial carcinoma.		2001	87699
nelson's eye.		2001	87735
plasma-triglycerides do not regulate high-density lipoprotein concentrations.	diets high in carbohydrate and diets restricted in fat and calories were used to induce large fluctuations in plasma-triglycerides in patients with severe familial hypertriglyceridaemia. high-density-lipoprotein (hdl) concentrations were estimated by radioimmunoassay of the major hdl apoprotein, apo a-i, and were correlated with plasma cholesterol and triglyceride concentrations. patients with type-1 hyperlipoproteinaemia had apo a-i concentrations about 50% of normal, and no increase in apo a-1 ...	2001	87831
new consultant contract.		2001	87861
optimised blood-pressure.		2001	87900
psychiatric patients: how long do they stay?		2001	87916
sex ratio in glomerulonephritis.		2001	87939
minaxolone: a new water-soluble steroid anaesthetic.	the induction characteristics of minaxolone, a water-soluble steroid anaesthetic, were studied in fit patients undergoing minor urological or gynaecological operations. minaxolone acted as rapidly as thiopentone. a dose of 0.25 mg kg-1 did not always produce anaesthesia in patients who had not received premedication but 0.5 mg kg-1 was an adequate dose. excitatory effects were less common with the higher doses of anaesthetic. these effects were usually slight and rarely interfered with the cours ...	2001	87969
donor selection in platelet transfusion therapy of alloimmunized thrombocytopenic patients.		2001	88057
prostatic acid phosphatase and prostatic cancer.		2001	88065
individual mice recognize the complex nature of h-2 antigens; unexpected reactions (anti-kk) in anti-balb/c-h-2d sera produced in the balb/c-h-2db mutant.		2001	88092
human corneal endothelium in organ culture. the influence of temperature and medium of incubation.	forty-four human corneas from patients between 21 and 86 years were incubated in eagle's minimum essential medium with earle's salts 10--46 h post mortem. the influence of incubation temperature and composition of the medium on endothelial survival was evaluated. whole corneas were stained by alizarine red. recent cell loss was indicated by morphological alterations in the endothelial pattern. after 20--28 h of incubation minimum cell loss was found at 31 degrees c when 8% dextrane-250 and 20% s ...	1979	88158
research needs in low vision.	research needs are presented for several areas of low vision: (1) reading and learning, (2) new low-vision aids, (3) modifying the environment, (4) utilization of disciplines, (5) new technologies, and (6) integrating low-vision services.	2001	88182
tannic acid staining and extraction of enzymes in polyacrylamide gel electrophoresis.		2001	88190
denaturization of allergen p: effect on allergenicity, antigenicity and immunogenicity.	when allergen p was denatured by 8m urea, the modified molecule still reacted with ige specific for the native allergen but not with hemagglutinating antibodies. heating at 100 degrees c abolished the reaction in both cases. the results suggested differences between allergenic and antigenic capacities which may be based on structural differences of the antigenic determinants.	1979	88195
carcinoma of the esophagus: pretreatment assessment, correlation of radiation treatment parameters with survival, and identification and management of radiation treatment failure.	between january 1969 and february 1975, 344 patients with carcinoma of the esophagus were managed primarily at the princess margaret hospital, toronto. one hundred sixty-eight (168) of the patients were treated palliatively and 176 of the patients were treated by radical doses of radiation, surgical resection or both. survival of the radical treatment group was biphasic, the steeper component being identical to the survival of the palliative treatment group, thereby representing a group of patie ...	2001	88252
the role of p23,30-bearing human macrophages in antigen-induced t lymphocyte responses.		1979	88270
electroimmunoassay of factor ix in patients with liver damage and vitamin k unresponsive coagulation disorder.	factor ix antigen and activity were assayed in a group of patients with liver disease and in a group of patients in coumarin therapy. in patients with liver disease there was a similar decrease in activity and antigen. on the other hand factor ix activity is decreased in coumarin treatment with factor ix antigen remaining normal. factor ix electrophoretic mobility in liver disease is normal.	2001	88391
genetic control of in vivo immunity to tumor-specific transplantation antigens of chemically induced murine fibrosarcomas.		2001	88423
ischemic lesions of the hippocampus and their relation to ammon's horn sclerosis. a neuropathological study of two cases and a comparison to the vascular anatomy.	two adult brains with small ischemic lesions in the hippocampus, due to impairment of the supply from the posterior cerebral artery, are presented. the first case corresponds to what is described in the literature as "incisural sclerosis" and shows no difference in vulnerability between the sommer and the spielmeyer sector. in the second case the hippocampal lesion is due to an embolic occlusion of the posterior cerebral artery and consists of selective necrosis of the subiculum, the sommer sect ...	2001	88508
lowering blood-pressure.		2001	88583
aspirin and bleeding-time: dependency of age.		1999	88626
haemodilution and blood-flow.		1999	88643
[a case of sinus thrombosis causing hemorrhagic infarction (author's transl)].		1999	88686
fuorescent retrograde neuronal labeling in rat by means of substances binding specifically to adenine-thymine rich dna.	six fluorescent substances, binding specifically to adenine-thymine rich dna, were injected in rat caudate-putamen. this resulted in retrograde axonal transport and fluorescent retrograde labeling of neurons in center-medium parafascicular nucleus, substantia nigra and dorsal raphe. two of these substances, i.e. "true blue' and 'granular blue', give a very striking blue fluorescent retrograde neuronal labeling. mid-thoracic spinal injections of these two substances in rat also resulted in a pron ...	1979	88697
drugs or drums: what relieves postoperative pain?	the cybernetic model of analgesia is a simple servo-loop: altered sensory input--complaints--medication--temporary restoration of acceptable processing of the sensory input--return of altered sensations. under ordinary clinical circumstances the functioning of this mechanism is masked by "noise" generated by the interaction of several persons who provide the medication and time factors prolonging the interval between the onset of complaints and the action of the medication. demand analgesia (da) ...	2000	88710
dansylcadaverine specific staining for transamidating enzymes.		1979	88908
a new assay of estrogen receptor by thin-layer gel filtration.		1979	88911
[post-extrasystolic and post-pacing potentiation. i. experimental study of the isolated heart of the rabbit].		1978	88947
[nuclear surface of buccal cells as a function of the nature of the stain. measurements with an image analyzing computer].	measure of nuclear areas was performed on buccal smears by the quantimet 720 image analysing computer. five different staining procedures were used and we consider that toluidin blue at ph 4 is the best for a fine quantitative caryometry.	2001	88973
use of thermal image film for demonstrations of computer-assisted searching.		2001	88978
reaction of cells from early chick embryos with antiserum against mouse sperm cells.		1979	89009
binding specificity of rat alpha-fetoprotein for a series of estrogen derivatives: studies using equilibrium and nonequilibrium binding techniques.	the binding specificity of rat alpha-fetoprotein (afp) for a series of estrogen derivatives has been investigated and compared to that of the uterine cytosol estrogen receptor. in addition, several equilibrium and nonequilibrium binding techniques have been examined for their appropriateness in studying afp-estrogen interactions under different experimental conditions. the ratio of association constants (rac) of various estrogen derivatives (compared to 17 beta-estradiol; rac = 100%) were determ ...	1979	89027
trasylol prevents trypsin-induced shock in dogs.	the effect of simultaneous intravenous administration in the dog of bovine trypsin and trasylol followed by continued infusion of trasylol was studied. special attention was paid to the interchange between the dominating plasma protease inhibitors alpha1-antitrypsin and a-macroglobulins and to the disappearance of trasylol and its trypsin complexes from the circulation. the following results were obtained: 1) trypsin was preferentially bound by the alpha-macroglobulins, though trasylol is a stro ...	1979	89067
translating the new testament into simple english and signs for the mentally retarded deaf.		1999	89069
differential inducibility of epstein-barr virus in cloned, non-producer raji cells.	cells of the human lymphoblastoid non-producer line raji were cloned in soft agar. individual colonies were isolated and analyzed for their inducibility of the epstein-barr virus-associated early antigen (ea). the induction of ea by the tumor promoter tpa varied among the different cell clones. clones with very high and very low inducibility of the resident epstein-barr virus genome were further analyzed. constant differences in the inducibility of ea were observed after activation by tumor prom ...	1979	89100
preparative isolation of the cell receptor for immunoglobulin e.		1979	89114
[esophago-jejunostomy at the level of the neck for restoration of continuity in carcinoma of the esophagus (after esophageal resection or for palliative reasons) (author's transl)].	a technic of esophago-jejunostomy in the neck is described which uses a y loop, to which is given a further blood supply through the internal mammary vessels, united to the vessels of the transplanted loop through microsurgical anastomoses. this technic is used either for purely palliative reasons or when the esophageal tumour has become inoperable, or after esophagectomy as a procedure for reconstruction of the digestive tract.	1999	89117
hospitalization of the elderly patient for acute illness.	there is a paucity of studies on the characteristics of elderly patients who are admitted for treatment of acute disorders, even though their utilization of hospitals is high. this study involved 828 older persons admitted to a general hospital during a period of six months, for the treatment of acute illness. the typical patient appeared to be a woman in her 70's who entered the medical department because of a cardiovascular or a gastrointestinal disturbance, stayed no longer than 10 days, and ...	1999	89134
control of v kappa expression in the mouse. i. unexpected expression of the v kappa allele, igk-pcb, in a somatic cell hybrid of akr (igk-pca) origin.		1979	89158
inheritance of tolerance susceptibility to human gamma-globulin in congenic mice.	the genetic control of susceptibility to tolerance induction with human gamma-globulin (hgg) was studied by using h-2 congenic mice. strains tested that were congenic with c57bl/10sn were completely tolerized by 1.0 mg deaggregated hgg. in contrast a/sn mice showed full tolerance whereas a.sw mice were only intermediately tolerant. it was further shown that (b10 x sjl)f1 mice could be rendered tolerant but (b10.s x sjl)f1 mice could not. these data indicate a role for h-2 linked genes in control ...	1979	89162
demonstration and partial characterization of 22-nm hbsag and dane particles of subtype hbsag/ady.	the present paper describes the demonstration of d, y, w, and r hbsag determinants in one serum. it was shown that there are two populations of hbsag particles: hbsag/ad and hbsag/ady. all complete dane particles were of subtype hbsag/ady. further characterization of hbsag/ady particles did not reveal morphologic differences when they were compared with hbsag/ad and hbsag/ay particles. an hbsag/ady phenotype may be the result of a double infection with hepatitis b viruses or exchanges of dna seq ...	1999	89163
atrial repolarization: its role in st elevation.	in four patients, ectopic supraventricular rhythm (or beats) with cephalad anomalous atrial activation and, generally, a short pr, were always associated with an st elevation in the leads with a negative p wave. an inverted ta wave appears to be responsible for the st elevation.	1999	89183
antigenic changes associated with liver carcinogenesis.	carcinogen-induced experimental hepatomas are often characterized by new individually distinct antigens capable of inducing tumor immunity in syngeneic hosts. these antigens arise as a consequence of cell-carcinogen interaction and may result from modification or replacement of normal cell-surface components. their role in immunosurveillance is not established, but they offer a target for tumor immunotherapy. reexpressed fetal antigens have also been detected, either as secretory products (alpha ...	1979	89200
new screening test for colorectal cancer developed in canada.		1999	89207
[preparation of antisera by combined administration of antigens].		1979	89268
increase in leg blood-flow by normovolaemic haemodilution in intermittent claudication.	normovolaemic haemodilution down to a packed-cell volume of 35% was done in 10 patients with stable intermittent claudication. for a mean reducation in the packed-cell volume of 21.5% there was a 170% increase in peak calf blood-flow and a 111% increase in haemoglobin delivery. 7 of the 10 patients reported an increased walking distance. normovolaemic haemodilution may be of use in the management of some patients with peripheral vascular disease.	1999	89279
the royal commission.		1999	89285
actual or standard bicarbonate.		1999	89314
percutaneous transluminal coronary angioplasty.		1999	89339
fine-needle aspiration cytology.		1999	89365
health care in inner city areas.		1999	89385
paraquat poisoning: significance of plasma-paraquat concentrations.	plasma-paraquat concentrations were measured in 79 patients who had ingested liquid or granular weedkillers containing paraquat. at any given time after ingestion, the plasma-paraquat concentrations in the patients who died usually exceeded those in the survivors. it is suggested that measurement of plasma-paraquat concentrations is useful in assessing the severity and predicting the outcome of poisoning. patients whose plasma concentrations do not exceed 2.0, 0.6, 0.3, 0.16, and 0.1 mg/l at 4, ...	1999	89392
antacids and cricoid pressure in the prevention of fatal aspiration syndrome.		1999	89406
medical womanpower.		1999	89418
immune complexes after milk ingestion.		1999	89422
distinguishing unipolar and bipolar depression by thyrotropin release test.		1999	89464
acute renal failure due to rhabdomyohaemolysis in beta-thalassaemic trait.		1999	89541
aspects of epidural morphine.		1999	89585
colophony and asthma.		1999	89600
fibre, satiety, and energy balance.		1999	89607
the influence of decalcifying fluids on the demonstration of mycobacterium tuberculosis in paraffin sections.		1979	89611
[premature beats with normal intraventricular conduction in the framework of intraventricular conduction disorders. complete left branch block and left anterior hemiblock].		2000	89644
case report: treatment of posterior bite collapse with secondary occlusal traumatism.		2000	89659
fluorochrome staining of multilamellar liposomes.	multilamellar liposomes can be stained with such fluorochromes as acridine orange, eosin y, neutral red, and thiazine red. the liposomes are brought into a 1% solution of the fluorochrome; 5-10 minutes later they are centrifuged and washed by resuspending in water or phosphate buffered saline three times. the last pellet is resuspended and a drop studied with the fluorescence microscope (1000 x magnification). the fluorochrome is seen to be accumulated in the liposomal membranes. acridine orange ...	2000	89716
a comparison of methods using diaminobenzidine (dab) to localize peroxidases in erythrocytes, neutrophils, and peroxidase-antiperoxidase complex.	reactions using diaminobenzidine (dab) to localize the enzyme peroxidase in neutrophils and peroxidase-antiperoxidase (pap) complex during immunological staining are usually performed in tris-hcl or phosphate buffer at ph 7.2-7.6. however, dab solutions at ph 7.2-7.6 often demonstrate erythrocyte pseudoperoxidase as well. by lowering the ph of the dab solutions, it is possible to selectively suppress the reactivity of pseudoperoxidase while maintaining optimal reactions in neutrophils and pap co ...	1978	89720
monkey antiserum to mlc-primed human t lymphocytes.		1979	89737
histological diagnosis of myocardial injury. comparison of hematoxylin-basic fuchsin-picric acid (hbfp)-stained sections obtained during autopsy with isolated viable rat cardiac myocytes exposed to anoxia.	the light microscopic appearances in hematoxylin-basic fuchsin-picric acid (hbfp)-stained histological sections from cardiac and skeletal muscle tissue were put in relation to the reactions of isolated viable rat cardiac myocytes exposed to anoxia in suspension and their morphology in paraffin-embedded sections. special attention was paid to prenecrotic phases of myocytic injury which were followed, in viable rat cardiac myocytes, by light microscopy, and confirmed with biochemical assays indica ...	1979	89781
histamine-releasing effect of a corticotrophin derivative. ii. mechanism of action of histamine release by c 44 680-ba, compared with that of cpd. 48/80, dextran and triton.	the mechanism of the histamine-liberating action of the synthetic polypeptide c 44 680-ba, an alkyl-prolyl derivative of beta 1-19 corticotrophin, was investigated and compared with those of compound 48/80, dextran, melittin and triton x-100. it was found that the release of histamine from rat peritoneal cells induced by the polypeptide is dependent on temperature, ph, calcium ions and energy-providing processes. in regard to these criteria, the mode of action of this histamine liberator resembl ...	1979	89804
steroid secretion by in vitro perfused testes: inhibitors of testosterone biosynthesis.		1979	89816
effect of encephlitogenic protein. ppd and tetanus toxoid on leukocyte migration in agarose. a study of "cross-reactivity".	the reactivity to three antigens: bovine encephalitogenic protein (ep), ppd, and tetanus toxoid, was studied with blood leukocytes from healthy humans using clausen's (5) leukocyte migration in agarose technique. there is an obvious correlation between the reaction of ep (all concentrations studied) and to low concentrations of ppd; and between the reactivity to low concentrations of ep and low concentrations of tetanus toxoid. after vaccination with tetanus vaccine, a marked increase in reactiv ...	1979	89821
studies and critique of amido black 10b, coomassie blue r, and fast green fcf as stains for proteins after polyacrylamide gel electrophoresis.		2000	89822
antibodies in histoplasmosis detected by use of yeast and mycelial antigens in immunodiffusion and electroimmunodiffusion.		1979	89825
inhibition of histamine release from rat mast cells by cytochalasin a and other sulfhydryl reagents.		1979	89848
alcohol and the blood.		2000	89860
alpha-fetoprotein as a carrier protein in plasma and its bilirubin-binding ability.	the bilirubin-binding ability of human alpha-fetoproteins, which were purified from fetal cord serum and from ascites fluid of a hepatoma-bearing patient, was examined by the difference spectrum and the jacobsen peroxidase methods. the difference spectrum observed as a result of the specific binding of bilirubin to alpha-fetoprotein had a maximum at 482 nm, and this pattern was quite similar to that observed for serum albumin. the result obtained by the difference spectrum method showed that 1 m ...	1979	89900
rat alpha-macrofetoprotein (acute-phase alpha 2-macroglobulin) during hepatocarcinogenesis.	rat alpha-macrofetoprotein (amf) and alpha-fetoprotein (afp) are secreted by the fetal liver and become elevated in serum during hepatocarcinogenesis and in animals bearing hepatocellular carcinomas. it has been suggested that these fetal plasma proteins may be influenced by related control mechanisms. the experiments presented herein examined the early responses of these plasma proteins during hepatocarcinogenesis using the hepatocarcinogens acetylaminofluorene and diethylnitrosamine. under the ...	1979	89903
coupling between neuronal activity and focal blood flow in experimental seizures.	local blood flow, ecog and single cortical neurone activity were recorded simultaneously from single microelectrodes in 17 cats. seizures were induced by repeated intravenous injections of pentylenetetrazol (ptz, 10-20 mg/kg) or by local application of 1 m na-penicillin. seven to 20 sec after appearance of burst activity in cortical neurones and ecog, focal flow increased up to 300% of control. the extent of this flow increase was significantly correlated with the change in firing rate of the ne ...	1979	89943
pattern of condensation of mouse and chinese hamster chromosomes in g2 and mitosis of 33258-hoechst-treated cells.		1979	89960
[pre- and postoperative erythrocyte volume distribution curves in children with cyanotic heart defects].	the behaviour of the volume distribution curves (vvk) of red blood cells in children with cyanosed organic heart defect is reported by taking preoperative and postoperative observations as a basis. mcv determined from the volume distribution curve amounts to 80.3 micron3. if the volume distribution curves of the preoperative patient group are compared with the postoperative patient group (4 months) by means of the criteria dsmax, ds, inclination and dispersion, no significant changes can be iden ...	2000	89988
[sialic acid content and igg binding of the glycocalyx of preserved erythrocytes].	fractions of light and heavy erythrocytes were separated by centrifugation from blood samples banked in acd-ag medium at 4 degrees c for periods up to 6 weeks. both light and heavy erythrocytes have lost about 4,9% of their content of sialic acids during banking for 6 weeks. this reduction is in accord with a 6%-decrease of their agglutination by means of alcian blue. it is, however, a variance with the inhibition of agglutination by anti-igg sera. the present findings provide evidence for the r ...	2000	89989
revertants of adenovirus type-12-transformed hamster cells have lost part of the viral genomes.		1979	90022
topographical variations in the structure of the smooth septate junction.	smooth septate junctions in the midgut of musca domestica and in malpighian tubules of both musca and rhodnius prolixus are described. details of the structures revealed after standard fixation, fixation in the presence of the stain, lanthanum hydroxide, and after freeze-fracture are discussed in the light of models previously put forward to explain the interrelations of the images obtained by these different methods. the organization of the junction between cells of the midgut varies in the api ...	2000	90053
inhibition by non-steroidal anti-inflammatory agents of the ascorbate-induced elevations of platelet cyclic amp levels.	ascorbate induces a 10- to 25-fold rise in platelet guanosine 3'5'-cyclic monophosphate (cgmp) and this action is prevented or reversed by the introduction of aspirin, indomethacin, ro 5,8,11,14-eicosatetraenoic acid (tya). the reversal was 70-90% complete at 30 s, the earliest time point that was examined. as the effect of ascorbate on cgmp was not diminished by anaerobic conditions, which inhibited the oxidation of exogenous arachidonate by more than 95%, metabolic inhibition of cyclo-oxygenas ...	2000	90062