Publications

a possible new enterovirus serotype isolated in ontario.		1971	4109494
listeria monocytogenes infections in canada.	between 1951 and january 1972 listeriosis was diagnosed bacteriologically in 101 canadian patients. this study adds 80 cases to the 21 reported from metropolitan toronto by sepp and roy in 1963. the laboratory centre for disease control, ottawa, collated epidemiological and clinical data. serotypes of listeria monocytogenes included 4b (53), 1 (15), 1b (6), 1a (2), 2 and 3. clinically, 54 patients had meningitis and 23 septicemia. the mortality rate was 30%.between 1954 and january 1972 listerio ...	1973	4198595
interference of influenza-specific iga antibodies present in throat washings with isolation of the virus.		1973	4201894
chromosome aberrations in 2159 consecutive newborn babies.		1969	4238063
human trichinosis: report of four cases, with emphasis on central nervous system involvement, and a survey of 500 consecutive autopsies at the ottawa civic hospital.	in 1963, acute trichinosis was recognized in four patients at the ottawa civic hospital. one presented with cavernous sinus thrombosis and sixth nerve palsy. a second had a severe systemic infection with myocarditis; the signs of myocarditis appeared in the third week. electrocardiographic abnormalities included t-wave flattening, prolongation of pr interval and qrs complex, and non-specific changes in 25%. central nervous system involvement occurred in the second week with general symptoms (hea ...	1966	4288427
myxovirus dissemination by air.	myxoviruses including 150 strains of parainfluenza 1, 15 of parainfluenza 3 and five of influenza b virus were isolated from nasopharyngeal secretions obtained from 300 children less than 3 years of age who developed acute laryngotracheobronchitis during the preceding 48 hours. the patients were examined between october 1966 and january 1967, the peak monthly rate of virus isolation (67%) occurring during january. parainfluenza 1 virus was isolated from air obtained in the vicinity of one of 30 ...	1967	4290621
survey on the incidence of yersinia enterocolitica infection in canada.	data pertaining to 278 cultures of yersinia enterocolitica isolated in canada are summarized in this paper. of this amount, 256 were isolated from humans, whereas 22 were of nonhuman sources. the typing of these cultures is presented together with their geographical location. y. enterocolitica serotype o:3 biotype 4, phage type 9b, was practically the only serotype present in the province of quebec. this serotype o:3 was also predominant in ontario, followed by serotypes o:5,27 and o:6,30; other ...	1974	4472776
a new subtype of type a influenzavirus isolated from turkeys.	a new subtype of avian influenzavirus a was isolated in january 1967 from an epizootic in a turkey hatchery in ontario, canada. the disease was fatal in 65 of 2 500 hens involved. virus was isolated from lung and trachea tissue of three dead turkeys. sera from convalescent birds contained antibody against the viruses isolated from the outbreak but not against other known type a avian influenzaviruses, newcastle disease virus, myxovirus yucaipa, or mycoplasma gallisepticum.the strain designated a ...	1972	4541004
review of human renal transplantation at the toronto general hospital.		1973	4570266
bovine tuberculosis in humans in ontario. the epidemiologic features of 31 active cases occurring between 1964 and 1970.		1972	4627829
at sunnybrook medical centre: the human side of rehabilitation.		1973	4781704
the strengths and weaknesses of university review committees to protect human rights.		1974	4844661
viral infections of toronto children during 1965: ii. measles encephalitis and other complications.	among 16 cases of measles encephalitis observed in toronto during 1964 and 1965, including six who were stuporous or comatose on admission and five who presented with convulsions, measles virus was isolated from csf of one patient, rising titres of measles antihemagglutinin were detected in another patient, and 14 showed high antibody titres in sera collected as early as two to five days after onset of the measles rash. increasing levels of measles antibody were detected in paired sera from thre ...	1966	4952371
[a laboratory of human relations at honey harbour].		1966	5177426
[a laboratory of human relations].		1967	5182984
vitamin a reserves of canadians.	-a survey of vitamin a and carotene stores of canadians at five major centres across canada was completed. vitamin a and carotene analyses were performed on approximately 100 human liver specimens obtained at necropsy from each location.age influenced liver vitamin a stores. children between 1 and 10 years of age had the highest vitamin a stores while a trend toward lower liver stores occurred between 20 and 40 years of age. females had higher liver carotene stores than males but there was no su ...	1969	5364272
psittacosis in hamilton: a case report and epidemiological study.	a case report of a patient severely ill with psittacosis is presented, together with an epidemiological study of his fellow workers. this study illustrates the contagiousness of the disease and indicates that it is probably more prevalent than clinical experience suggests. only three of the 83 persons studied who were exposed became ill enough to seek medical attention. it is important that both the physician and the public be made aware of this disease so that definitive treatment can be instit ...	1970	5410417
strontium-90 and infant mortality in canada.		1970	5474939
central nervous system involvement associated with unclassified echovirus types.		1968	5645182
occurrence of echovirus 33 infections in ontario.		1968	5690127
rabies today--man and animals.		1969	5812488
"skid row" syndrome: a medical profile of the chronic drunkenness offender.	from skid row, 227 chronic "drunks", inmates of the toronto jail, were studied to determine the physical features and illnesses of this group. complete physical examinations, liver function tests, routine hematology, urinalysis, chest radiographs were carried out and previous hospital records were obtained for each man. the data were analyzed by ibm computer and reported in terms of body systems. items that occurred in sufficient frequency were separated out and listed to compile a "skid row" sy ...	1966	5947765
powassan virus: persistence of virus activity during 1966.	powassan virus isolations were achieved from three of 60 pools of ixodes cookei ticks removed from 286 groundhogs (marmota monax) which were collected some 200 miles north of toronto between may 5 and september 5, 1966. virus yields per pool of one to 11 ticks ranged from 10(2.5) to 10(6.0) tcd(50) for primary swine kidney tissue cultures, and positive pools were collected on june 24, july 15 and august 10. powassan neutralizing antibodies were detected by mouse inoculation tests in 143 of 362 a ...	1967	6019677
silver staining of dna restriction fragments for the rapid identification of adenovirus isolates: application during nosocomial outbreaks.	the ultrasensitive photochemical silver stain for nucleic acids, described by beidler et al. (1982), has been applied to the detection of adenovirus restriction fragments as a relatively rapid technique for the identification of virus isolates. in this study, restriction enzyme cleavage analysis was used to characterize adenovirus isolates from what appeared to be two nosocomial outbreaks. the first outbreak was thus shown to include two clusters of patients, and involved two serotypes ad7c and ...	1984	6210299
approaches to immunization of infants and young children against gastroenteritis due to rotaviruses.	recent studies have shown that in developed countries rotaviruses are the single most important etiologic agents of acute gastroenteritis that requires hospitalization of infants and young children. although deaths from gastroenteritis are, in general, infrequent in the developed countries, an effective rotavirus vaccine would clearly be of benefit to reduce the heavy toll of morbidity from gastroenteritis due to rotavirus. in the developing countries the impact of diarrheal diseases is staggeri ...	1980	6251528
a field trial, of preshipment vaccination, with intranasal infectious bovine rhinotracheitis-parainfluenza-3 vaccines.	a total of 849 calves, 278 controls, 335 vaccinated intranasally with ibr-pi3/ts and 236 vaccinated intranasally with ibr-pi3/ptc were studied in a field trial of preimmunization. all calves were vaccinated in saskatchewan at least three weeks prior to shipment to feedlots. four hundred and twenty six calves were not sold within eight weeks of vaccination; however, seven of these died within four weeks of vaccination. treatment rates varied from 1.0% to 5.2%. there was no significant effect of v ...	1983	6315194
inactivated poliovirus vaccine and test development at connaught laboratories ltd.	trivalent inactivated poliovirus vaccine (ipv) (mk) was made, purified, and inactivated according to the amended rijks instituut (the netherlands) protocol from primary monkey kidney tissue grown on microcarrier cultures. losses of the type 2 component due to adsorption to the glass ampule occurred with the purified vaccine preparation. this problem was solved by changing the diluent, and the vaccine was submitted for evaluation in clinical trials at johns hopkins (baltimore, md.). phase 2 of th ...	1984	6330837
listeria monocytogenes infections in canada.	since its first isolation by murray in 1926 listeria monocytogenes has become recognized as a significant pathogen occurring worldwide and involving a wide range of wild and domestic animals including man. the first confirmed human listeriosis case in canada was published by stoot in 1951. a later survey based on records maintained at the laboratory centre for disease control, ottawa showed 101 cases detected over a 21 year period in nine provinces. the overall mortality was 30%. the most freque ...	1984	6442654
larry grossman - man for the future.		1983	6550440
epidemiologic basis for photochemical oxidant standard.	the problem of photochemical oxidant pollution, 98% of which is ozone, is addressed. ozone itself is not the cause of all adverse effects (e.g., peroxyacetyl nitrites cause eye irritation). the typical sequence in the development of oxidant pollution is an initial increase in nitrous oxide, followed by nitrogen dioxide, followed by ozone. these pollutants can be carried long distances and may have long range effects. ozone is considered by far the most irritant gas to humans, with effects seen e ...	1983	6653514
human resource planning at toronto's baycrest centre.		1983	6680366
variability in caffeine metabolism.	urinary metabolites excreted after oral caffeine were quantified in a healthy sample (n = 68) from the toronto population by hplc analyses. the profile of metabolites, assessed by examining particular metabolite ratios, was found to differ widely among subjects. ratios denoting cytochrome p-450-dependent activities were shown to be interethnically variable between oriental and caucasian groups, whereas those indicative of xanthine oxidase activity exhibited neither significant interindividual va ...	1983	6687705
erythema infectiosum: an epidemic with a probable posterythema phase.	an outbreak of erythema infectiosum occurred in an ontario school in the spring of 1983. this benign disease ran a 19-day course in the index case and appeared in most of the child's grade 1 classmates. a few adults were also affected. in eight children flu-like symptoms persisted or occurred suddenly and lasted for several days after the rash had vanished. a plan of management that involves communication with parents, teachers and the public health service is outlined for the general practition ...	1984	6697272
a comparison of organochlorine residues in human adipose tissue autopsy samples from two ontario municipalities.	human adipose tissue samples obtained during autopsies in a canadian great lakes community, kingston, ontario, and a second community, ottawa, ontario, were analyzed for organochlorine pesticides, polychlorobiphenyls, chlorobenzenes, and chlorophenols. significantly different levels of dichlorodiphenyl -dichloroethane, mirex, hexachlorobenzene, and 2,3,4,6-tetrachlorophenol were found in kingston adipose tissues compared to ottawa tissues. residue levels of oxychlordane , mirex, and polychlorina ...	1984	6716511
characterization of strains of corynebacterium bovis.	the biochemical and morphological characteristics of 104 strains of corynebacterium bovis isolated from bovine milk samples and the c. bovis reference strain were found to be uniform. valuable criteria for identification were presence of catalase and oxidase, production of acid from glucose and fructose and a requirement for enriched basal media. six strains of human and three strains of bovine origin were found to be inconsistent with the reference strain.	1984	6722650
human rights versus occupational medicine.	this paper examines the conflict between the medical monitoring of workers and human rights. a lead regulation in force in ontario, despite its absolute conflict with an important guideline established by the canadian human rights commission, is presented as an example of the erosion of human rights by certain legislated activities in occupational medicine. the question of whether the benefits of occupational medical activities outweigh the disadvantages attendant upon the erosion of human right ...	1983	6853002
ethical and psychiatric aspects of torture: a canadian study.	in the last two decades widespread use of torture by totalitarian governments has been reported in over 60 countries. this situation concerns physicians who are sometimes called upon to see the victims. this paper reports the psychiatric findings in a group of 41 latin american refugees who arrived in canada from 1977 to 1979 and alleged to have been subjected to political persecution and torture under the military rulers of their own countries. most of them, young educated men, were apprehended ...	1982	7066853
quantitative interlake comparison of thyroid pathology in great lakes coho (oncorhynchus kisutch) and chinook (oncorhynchus tschawytscha) salmon.	coho salmon (oncorhynchus kisutch) and chinook salmon (oncorhynchus tshawytscha) from lakes ontario, michigan, erie, or huron were found to suffer epizootics of thyroid hyperplasia and goiters which appeared to have an environmental etiology. there were 13-fold differences in goiter prevalence within the great lakes, and the differences in goiter frequency were correlated with the degree of thyroid hyperplasia. a means of assessing the degree of thyroid hyperplasia (thyroid index) is described, ...	1981	7237420
community based monitoring for spinal man.		1981	7284945
yersinia enterocolitica isolated from throats of swine in eastern and western canada.	examination of the throat flora from swine in ontario for yersinia enterocolitica found the incidence of serotype o:3 to vary from 20% from tonsils to 50% for throat swabs and 55% for tongues. in contrast, there were no isolations of serotype o:3 from throat swabs taken from swine in the western provinces of british columbia and alberta. this incidence of serotype o:3 in swine correlates well with the human incidence of the same serotype which is 81% for all human isolations of y. enterocolitica ...	1981	7332882
[antigenic characterization of influenza a virus isolated from birds captured in ontario, quebec, and the maritime provinces during the 1977 season].	a total of 145 influenza a viruses were isolated from ducks, geese and passerine birds in ontario, québec and the maritimes in july-august 1977. antigenic characterization of these isolates included five hemagglutinin (hsw1, hav4, hav5, hav6, hav7) and five neuraminidase subtypes (n1, n2, neq1, neq2, nav1) in nine different combinations; one combination hav7 neq1 had not been previously reported. the majority of these viruses were hsw1 n1, antigenically related to influenza viruses in pigs and h ...	1980	7433721
quality control for peripheral stem cell collection: the ottawa experience.		1994	7535465
the law and ethics in relation to dentists treating hiv-positive patients: two recent court cases.	two recent canadian judgements regarding the application of human rights legislation to dentistry and hiv-seropositive patients are summarized and discussed. in the ontario case of jerome v. demarco, the ontario human rights tribunal found that seropositivity constitutes a "handicap" under human rights legislation. however, the tribunal dismissed the claim by a seropositive patient that he had been illegally discriminated against by a dentist who, on learning the patient was seropositive, delaye ...	1995	7614430
pcb and organochlorine pesticides in canadian human milk--1992.	human milk (497 samples) representing donors from across canada were analyzed for 24 organochlorine pesticides and industrial chemicals and 40 pcb congeners. pcbs, p,p'-dde, hexachlorobenzene (hcb), and trans nonachlor were present in all samples. compared to earlier surveys in canada, concentrations of most residues determined declined, and were lower than those reported recently in european countries. although regional differences were minor, residues of pcbs, p,p'-dde, and trans nonachlor wer ...	1995	7620848
prevalence of human immunodeficiency virus and associated risk behaviour in injection drug users in toronto.	during 1989-90, interviews were conducted with 582 current injection drug users in the city of toronto, 535 of whom also provided blood and/or saliva for anonymous unlinked hiv antibody testing. the rate of seropositivity identified was 4.3% (95% ci 3-6). the subjects were predominantly male, with a mean age of 28.3. the commonest drug of choice was cocaine (70%). forty-six percent of the subjects reported using someone else's needle in the preceding six months, 60% of these indicating that they ...	1995	7671202
hepatitis c virus infection in patients infected with the human immunodeficiency virus.	the prevalence and characteristics of hepatitis c virus (hcv) infection in 226 patients who were seropositive for human immunodeficiency virus (hiv) were determined. antibody to hcv (anti-hcv) was detected by enzyme immunoassay (eia), and positive results were confirmed by a neutralization eia or recombinant immunoblot assay. the prevalence of anti-hcv was 8%. intravenous drug use was the most common risk factor for hcv infection (61.1% of patients), and 52.4% of intravenous drug users were sero ...	1993	7688986
do doctors accurately assess coronary risk in their patients? preliminary results of the coronary health assessment study.	to evaluate the ability of doctors in primary care to assess risk patients' risk of coronary heart disease.	1995	7728035
a respiratory outbreak due to parainfluenza virus type 3 in a home for the aged--ontario.		1995	7749396
an influenza a outbreak in an ontario nursing home: estimates of vaccine efficacy.		1995	7749397
the hiv information project for transfusion recipients a decade after transfusion.	to gather information on which to base decisions about a general notification program for pediatric patients a decade after their receiving transfusions.	1995	7767426
1993-1994 influenza season: canadian laboratory diagnoses, strain characterization and post-season serosurvey (ontario).	in canada as a whole, influenza a/beijing/32/92-like virus was the dominant infecting strain in the 1993-1994 season with reported laboratory diagnoses peaking in january 1994. vaccination is again urged for all persons in high-risk groups. antibody induced by vaccination does not persist well from season to season and the emerging a/shangdong/9/93 (h3n2)-like variant is related to a/beijing/32/92(h3n2) but is inhibited less by antibodies to that strain. conditions are also consistent with possi ...	1994	7812234
canada to set up genome research centre in toronto.		1995	7830754
what happens to donated blood?	pursuing their chief work--gathering, processing and distributing blood--the blood donor centres of the canadian red cross society follow standard operating procedures like those in place at the ottawa centre. here, recruitment staff and volunteers work to recruit donors to meet needs at a time when the number of donors is falling. when they register, donors must show proof of identity. each receives a permanent identification number that is linked to the numbers assigned to the units of blood e ...	1995	7859200
validation of a decisional conflict scale.	the study objective was to evaluate the psychometric properties of a decisional conflict scale (dcs) that elicits: 1) health-care consumers' uncertainty in making a health-related decision; 2) the factors contributing to the uncertainty; and 3) health-care consumers' perceived effective decision making. the dcs was developed in response to the lack of instruments available to evaluate health-care-consumer decision aids and to tailor decision-supporting interventions to particular consumer needs. ...	1995	7898294
hereditary and familial ovarian cancer in southern ontario.	hereditary ovarian cancer may be site specific or may appear in combination with breast cancer or other cancers in a family. the most common hereditary form is the breast-ovarian cancer syndrome. it is estimated that in 100% of these families, there is linkage to a cancer susceptibility gene on chromosome 17q, brca1.	1994	7922985
a comparative analysis of the costs of administration of an osce (objective structured clinical examination).	the objective structured clinical examination (osce) has become an accepted technique for the evaluation of clinical competence in medicine. although advances have been made in our knowledge of the psychometric aspects of the osce, extremely little has been written about feasibility and cost issues. given the current economic imperative to control costs and the extremely scant literature on the costs of developing and administering an examination in medicine, the authors felt it timely and relev ...	1994	8018269
nickel in the terrestrial environment.	this paper provides an overview of nickel concentrations in the terrestrial environment especially as it relates to exposure of the metal to humans and animals through food. the information includes a review of reports published in the scientific literature substantially supplemented with data obtained across the province of ontario, canada. the topics covered include background levels and levels of nickel measured in a number of different types of biota exposed to environmental contamination. t ...	1994	8029689
repeatability of interview-derived information on sexual history: a study in women.	we assessed the repeatability of interview-derived information on age at first sexual intercourse and number of sexual partners in women participating in an ongoing prospective study of genital human papillomavirus infection in toronto, canada. of the 100 study participants invited to attend for re-interview twice during their first year in the study, 74 attended for the first follow-up interview about 5 months after recruitment, and 28 of these 74 subjects attended for a second interview about ...	1994	8038255
evidence of direct transmission of escherichia coli o157:h7 infection between calves and a human--ontario.		1994	8038753
transplantation of electively aborted human fetal tissue: physicians' attitudes.	to provide empirical data on the attitudes of ontario family physicians and gynecologists toward the use of electively aborted fetal tissue for transplantation (ftt).	1994	8039086
follow-up of a group of workers intoxicated with 4,4'-methylenedianiline.	4,4'-methylenedianiline (mda), an aromatic amine, is a known human hepatotoxin and an animal carcinogen but there is little information regarding its chronic effects in humans. between 1967 and 1976, 10 workers at a plant in ontario that used mda as an epoxy hardener developed acute jaundice. we followed this group from the date of intoxication through to the end of 1991 for cancer incidence by matching with the ontario cancer registry. to date, one cancer, a pathologically confirmed bladder can ...	1994	8074119
mapping a gene for congenital fibrosis of the extraocular muscles to the centromeric region of chromosome 12.	congenital fibrosis of the extraocular muscles (cfeom) is an autosomal dominant, ocular disorder characterized by congenital, nonprogressive, bilateral ptosis and external ophthalmoplegia. the pathophysiology of this disorder is unknown and it is unclear if it has a primary neurogenic or myopathic etiology. we report linkage of this disorder, in two unrelated families, to markers in the pericentromeric region of human chromosome 12. d12s59 does not recombine with the disease giving a two-point l ...	1994	8075644
an epidemiological investigation of pet ownership in ontario.	an epidemiological study was undertaken to elucidate factors associated with pet ownership. the study utilized questionnaires that were mailed to a systematic random sample of 700 households in the city of guelph and eramosa township. reasons for ownership were analyzed by factor analysis while differences between owning and nonowning households were investigated using logistic regression. sixty-five percent of dogs and 71% of cats were neutered. only 2% of urban and 3% of rural dogs had never b ...	1994	8076276
reaching out: bringing the human factor back to dialysis.	prior to the early 1980s, two winnipeg hospitals provided hemodialysis for all patients in manitoba with chronic renal failure. because no other hemodialysis centres existed, families were forced to relocate to the city. because of these factors, the manitoba renal failure advisory committee proposed the development of an outreach hemodialysis program. under the auspices of the health sciences centre in winnipeg, this outreach program has evolved into the current manitoba local centre dialysis p ...	1993	8148207
adam linton--the man.		1994	8184135
respiratory hospital admissions and summertime haze air pollution in toronto, ontario: consideration of the role of acid aerosols.	a study of air pollution and daily hospital admissions for respiratory causes was conducted in toronto, ontario. fine aerosol (da < 2.5 microns) samples were collected daily at a central city site during july and august 1986, 1987, and 1988 and were subsequently extracted and analyzed for daily particulate phase aerosol strong acidity (h+) and sulfates (so4 =). daily counts of respiratory admissions to 22 acute care hospitals and daily meteorological and environmental data (e.g. ozone [o3], tota ...	1994	8187742
comparison of dde and pcb residues in the general diet and in human blood--ontario 1986-87.		1993	8318765
a genetic study of neurofibromatosis type 1 (nf1) in south-western ontario. ii. a pcr based approach to molecular and prenatal diagnosis using linkage.	neurofibromatosis type 1 (nf1) is a common, autosomal dominant genetic disorder with a variety of highly variable symptoms including cutaneous manifestations (such as café au lait spots), lisch nodules, plexiform neurofibromas, skeletal abnormalities, an increased risk for malignancy, and the development of learning disabilities. the wide clinical variability of expression of the disease phenotype and high (spontaneous) mutation rate of the nf1 gene indicate that careful clinical examination of ...	1993	8320697
the groundhog tick ixodes cookei (acari: ixodidae): a poor potential vector of lyme borreliosis.	evidence for infection with the spirochete, borrelia burgdorferi, was sought in ixodes cookei and in groundhogs (marmota monax) in southern ontario, canada, and ticks fed on experimentally inoculated hosts were examined for the spirochete. borrelia burgdorferi was not detected by immunofluorescent examination of 110 larval, nymphal or adult i. cookei collected from the environment, or taken from humans and other animals. three groundhogs inoculated with b. burgdorferi developed titers of 1:20 to ...	1993	8355343
hospital response to psychosocial needs of aids inpatients.	compassionate care for hiv-infected persons requires response to psychosocial needs. with no new external funding, women's college hospital, a 270-bed urban teaching hospital, provided effective psychosocial services for hiv-infected inpatients by developing a comprehensive policy, educating staff, organizing existing services into a psychosocial support team to provide crisis intervention, and developing liaisons with community aids organizations. a retrospective chart review of epidemiologic a ...	1993	8377067
human immunodeficiency virus status in facial fracture patients.	a prospective study was performed to obtain an indication of the incidence of human immunodeficiency virus (hiv) among the population of facial fracture patients treated at a city hospital in toronto, ontario, canada. this study was stimulated by the observation that a significant number of the patients treated at this unit were drug and alcohol abusers, inmates of a local penitentiary (where homosexual activity is believed not to be uncommon) or had no fixed address. in addition, the surgical t ...	1993	8446709
age differences in stable carbon and nitrogen isotope ratios in a population of prehistoric maize horticulturists.	stable carbon isotope ratios in prehistoric human bone collagen have been used extensively to document the introduction and intensification of maize horticulture in notheastern north america. most previous studies are based on small samples of adults who are assumed to characterize the diet of the population. in this study, all 29 individuals buried within an ontario iroquoian village site dated a.d. 1530-1580 were analysed for stable isotopes of carbon and nitrogen. age distribution of the samp ...	1993	8460651
contamination of human ovarian follicular fluid and serum by chlorinated organic compounds in three canadian cities.	to determine the extent of contamination of ovarian follicular fluid and serum samples in women undergoing in-vitro fertilization and to study the effect of the contaminants on reproductive outcome.	1993	8462054
tuberculosis presenting with generalized lymphadenopathy, pulmonary infiltrates, and bone destruction in a young man.	although tuberculosis is still relatively common in canada, particularly among recent immigrants, one tends not to consider it very strongly in the absence of definite pulmonary symptoms and in the face of negative smears of expectorated sputum and bronchial washings. we present the case of a young immigrant from ethiopia who presented with mild constitutional symptoms, bony tenderness of the chest wall, generalized lymphadenopathy, and rib erosions--a set of features which, in the face of smear ...	1993	8494479
estimating fish consumption rates for ontario amerindians.	the routine assessment of human exposure to contaminants requires that exposure via consumption of freshwater fish be considered because many chemicals persist and/or bioaccumulate in fish. estimates of fish consumption rate were determined for ontario amerindians from data on the concentration of mercury in the hair of 4,327 amerindians residing in 58 reserves across the province, combined with data on mercury concentrations in three commonly consumed species of fish collected from lakes surrou ...	1993	8518545
hiv discrimination case.		1995	8521320
urban air quality and human health: a toronto perspective.		1995	8556685
leukemia after irradiation for endometrial cancer in ontario.	in human studies, the risk of leukemia after ionizing radiation has been found to be increased more often than for any other cancer. it is useful to study patients with cancer treated with radiation because exposure can be measured accurately, follow-up may be long, and often a comparable and sizable nonexposed group exists. women with endometrial cancer represent an excellent population for study because they meet these developed leukemia after endometrial.	1995	8625159
an artificial heart with the right connection.	led by dr. tofy mussivand at the university of ottawa heart institute, a team of canadian medical scientists, engineers, economists, physicians and medical devices manufacturers is working to bring a prototype artificial heart closer to clinical trials. key to this effort is the development of an electrical connector that can function for a long period in the harsh environment of the human body. such a connector will enable various components of the artificial heart, such as the internal battery ...	1996	8630841
reducing demand for physician visits through public education: a look at the pilot cold-and-flu campaign in london, ontario.	to estimate the effect of the ontario ministry of health's pilot public-education campaign launched in london, ont., on jan. 15, 1994, to reduce the number of visits to physicians' offices because of cold and flu symptoms.	1996	8634961
canadian patient played key role in uncovering secrets about early-onset alzheimer's disease.	last june, the university of toronto announced that canadian scientists and a team of international researchers had discovered the gene responsible for most cases of early-onset alzheimer's disease. one of the key players in that discovery had died just 3 months earlier. frances hodge, who participated in a battery of tests for the 20 years she lived with the disease, helped lead researchers to gene s182--and an ember of hope for future generations.	1996	8634971
invasive group a streptococcal infections in ontario, canada. ontario group a streptococcal study group.	several reports suggest that the incidence of invasive group a streptococcal infections, including streptococcal toxic shock syndrome and necrotizing fasciitis, is increasing.	1996	8684408
pharmacists' provision of continuity of care to patients with human immunodeficiency virus infection.	a pharmacy program for providing continuity of care to patients infected with human immunodeficiency virus (hiv) is described. the program was implemented at three practice sites in toronto: a tertiary care teaching hospital; an outpatient community pharmacy that is part of the hospital; and an ambulatory care clinic affiliated with the hospital. an hiv pharmacy practice was established at the hospital in 1993. the community pharmacy serves at least 30% of the hiv-infected patients in ontario wh ...	1996	8744462
invasive infection with streptococcus iniae--ontario, 1995-1996.	during december 1995-february 1996, four cases of a bacteremic illness (three accompanied by cellulitis and the fourth with infective endocarditis, meningitis, and probable septic arthritis) were identified among patients at a hospital in ontario. streptococcus iniae, a fish pathogen not previously reported as a cause of illness in humans, was isolated from all four patients. all four patients were of chinese descent had a history of preparing fresh, whole fish; three patients for whom informati ...	1996	8769472
the effects of ambient ozone on lung function in children: a reanalysis of six summer camp studies.	studies of children attending summer camps often have observed relationships between daily outdoor ozone (o3) concentrations and decreased lung function that are qualitatively similar to results seen in human chamber studies. the former studies, focusing on the pulmonary effects of o3 and associated pollutants on children under natural conditions of exposure, are potentially of great importance to understanding the public health impact of ambient o3. however, a thorough assessment of the results ...	1996	8820584
canadian health databases relevant to great lakes basin research.	several population-based health databases exist in canada which provide valuable systematic information for facilitating epidemiological evaluation of human health in the great lakes basin. they include the long-established canadian mortality database, a national birth defects registry, a provincial hospitalization database, and provincial and national cancer registry systems. the most recent addition is the national enhanced cancer surveillance system which currently is being implemented to all ...	1996	8843571
streptococcal toxic shock syndrome in dogs.	to determine the clinical, pathologic, and bacteriologic findings in dogs that developed severe invasive infections with group g streptococci (ggs) over a 6-month period in southern ontario.	1996	8870738
sensitive and controversial ethical issues subject of groundbreaking toronto exhibit.	medical research and practice have always posed many ethical dilemmas for scientists and physicians, but technologic advances mean that the questions are becoming even more difficult. that is why an exhibit, a question of truth, that is being prepared at toronto's ontario science centre is so timely. it examines the biases and political climates in which science operates, as well as the relative subjectivity of truth, knowledge and reality.	1996	8943940
psychiatric disability in ontario.	to describe the disability associated with psychiatric disorder in a community sample in order to refine estimates of service need and identify subgroups with greater priority for intervention.	1996	8946079
genetic variation of intestinal fatty acid-binding protein associated with variation in body mass in aboriginal canadians.	we hypothesized that genomic variation affecting the primary amino acid sequence of the intestinal fatty acid-binding protein would be related to variation in body mass index and associated clinical phenotypes in aboriginal canadians. we studied 507 adult native canadians from an isolated community in northern ontario. we found that the frequency of the t54 variant of the intestinal fatty acid-binding protein gene was 0.14 in this sample. the presence of this variant was associated with signific ...	1996	8954037
making our offices universally accessible: guidelines for physicians.	to develop recommendations for office-based physicians who wish to make their offices accessible to all patients.	1997	9068570
the futility of utility: barriers to the development of nursing human resource policies for ontario.		1997	9086966
the canadian human activity pattern survey: report of methods and population surveyed.	the assessment of health risk due to environmental contaminants depends upon accurate estimates of the distribution of population exposures. exposure assessment, in turn, requires information on the time people spend in micro-environments and their activities during periods of exposure. this paper describes preliminary results including study methodology and population sampled in a large canadian survey of time-activity patterns. a 24-hour diary recall survey was performed in 2381 households (re ...	1996	9097012
infection control in the orthodontic office in canada.	because of the difficulty of identifying infected persons, current recommendations for infection control are to treat all patients as if they are infected with blood-borne pathogens such as human immunodeficiency virus (hiv) and the hepatitis viruses. dentists' compliance with these recommendations has been investigated previously, however, there are few data related to orthodontists. the objective of this study was to measure the proportion of orthodontists who report the use of recommended inf ...	1997	9294356
the prevalence of positive hepatitis b, hepatitis c, and hiv serology in cornea donors prescreened by medical and social history in ontario, canada.	to determine the prevalence of hepatitis b (hbv), hepatitis c (hcv), and human immunodeficiency virus (hiv) in the serum of cornea donors who had been previously screened by social and medical history by the eye bank of canada, ontario division.	1997	9294680
mycobacterium xenopi infection in patients with human immunodeficiency virus infection.	mycobacterium xenopi is one of the most frequently isolated nontuberculous mycobacteria in ontario, canada. we reviewed the records of 28 human immunodeficiency virus (hiv)-infected patients from whom m. xenopi was isolated between 1982 and 1995. m. xenopi was recovered from respiratory specimens from 24 patients, most of whom had clinical and radiographic evidence of pulmonary disease. however, coexistent pulmonary infection due to other pathogens was found in 17 patients: pneumocystis carinii ...	1997	9332511
the legal implications of the veterinarian's role as a private practitioner and health professional, with particular reference to the human-animal bond: part 2, the veterinarian's role in society.		1997	9332754
status of trichinella spiralis in domestic swine and wild boar in canada.	evidence of the status of trichinellosis in canada's national swine herd is provided from data acquired through national surveillance programs and from a prevalence study of trichinella in wild boar and domestic swine. more than 500,000 swine tested at abattoirs in ongoing animal health surveys since 1980 and 2 national swine serological surveys (1985 and 1990) showed no evidence of trichinella infection, except for 3 occurrences in a small infected zone in nova scotia. the prevalence study of d ...	1997	9342448
the infection control practices of general dental practitioners.	to investigate the infection control practices of general dentists in ontario in 1994.	1997	9350462
persistence of escherichia coli o157:h7 in dairy cattle and the dairy farm environment.	the persistence of escherichia coli o157:h7 in cattle and the farm environment was investigated on eight ontario dairy farms positive for e. coli o157:h7 in a longitudinal study commenced one year previously. faecal samples from cows, calves, humans, cats, rodents, wild birds, a composite fly sample and numerous composite and individual environmental samples were cultured and tested for verotoxin-producing e. coli (vtec). vtec isolates were serotyped and e. coli o157:h7 isolates were phage typed ...	1997	9363025