Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| ige responses to dermatophagoides pteronyssinus native major allergens der p 1 and der p 2 during long-term specific immunotherapy. | we investigated by elisa the ige response to whole extract of the house-dust mite dermatophagoides pteronyssinus (dp) and to the native major allergens, der p 1 and der p 2, in sera from 18 adult patients (group a) with dp-allergic asthma before (t0) and 1, 2, 3, and 4 (t1-t4) years after subcutaneous specific immunotherapy (sit). a qualitative reduction (p = 0.05) of the ige responses to dp and der p 2 was observed from t1 to t4, but a highly statistical significant decrease appeared at t3 (p < ... | 1997 | 9404565 |
| organ-specific effects of 3,5,3'-triiodothyroacetic acid in rats. | in order to compare the effect of 3,5,3'-triiodothyroacetic acid (triac) with those of triiodothyronine (t3) and thyroxine (t4), severely hypothyroid rats (n=56) were infused over 13 days with 1, 2 or 4 nmol/100 g body weight (bw) per day of t3 or 2, 4 or 8 nmol/100 g bw per day of t4 or triac. the 8 nmol/100 g bw per day of t4 or triac induced the same increase in resting metabolic rate, yet 4 nmol/100 g bw per day of t3 was more potent (p < 0.05). for inhibiting serum tsh levels, 2 nmol/100 g ... | 1997 | 9405035 |
| defective stimulation of thyroxine 5'-deiodinase activity by cold exposure and norepinephrine in brown adipose tissue of monosodium glutamate-obese mice. | in order to examine the possible change in the thyroid hormone metabolism in the monosodium glutamate (msg)-obese mice, we determined the iodothyronine deiodinase activity of brown adipose tissue (bat), liver and kidney of male and female mice. there was no significant difference in the type ii thyroxine 5'-deiodinase (t4 5'dii) activity in bat between msg-obese and control mice when they were kept at the ambient temperature of 22 degrees c. t4 5'dii activity in bat of control mice increased mar ... | 1997 | 9405975 |
| distribution and reciprocal interactions of 3h-melatonin and 125i-thyroxine in peripheral, neural, and endocrine tissues of bullfrog tadpoles. | tissue distribution of 125i-thyroxine (t4) and 3h-melatonin and the effect of each hormone on the tissue content of the other were studied because previous work indicated that melatonin antagonized metamorphosis through peripheral, as well as thyroidal effects. late pre- to prometamorphic rana catesbeiana tadpoles on an 18 light:6 dark cycle were used for injection of hormones in vivo or to supply tissues for in vitro hormone administration. labeled melatonin uptake was highest in intestine, ven ... | 1997 | 9406444 |
| concomitant cisplatin/5-fu infusion and radiotherapy in advanced head and neck cancer: 8-year analysis of results. | the purpose of this study was to analyze long-term follow-up of a single institution's experience with a regimen of concomitant cisplatin/fluorouracil (5-fu) infusion and radiation given every other week. this analysis was stimulated by results of a randomized trial showing superiority for this regimen over induction cisplatin/5-fu chemotherapy followed by radiotherapy, especially in regional disease control. | 1997 | 9406747 |
| l-thyroxine directly affects expression of thyroid hormone-sensitive genes: regulatory effect of rxrbeta. | l-thyroxine (t4) has been considered mainly a prohormone, the hormonal action of which is related to its conversion to 3,5,3'-triiodothyronine (t3) in peripheral tissues. in this study we investigated in transient transfection assays whether t4 might directly affect the expression of thyroid hormone (th) sensitive genes. the reporter construct me-tre-tk-cat or tsh-tre-tk-cat containing the nucleotide sequence of the th response element (tre) of either malic enzyme (me) or tshbeta genes, was tran ... | 1997 | 9406846 |
| comparison of neuromuscular action of rocuronium, a new steroidal non-depolarizing agent, with vecuronium. | rocuronium is a new nondepolarizing muscle relaxant. it features a rapid onset and lack of histamine release: it has an intermediate onset of action as vecuronium. the purpose of this study was to compare the neuromuscular action and condition of intubation after a bolus dose of rocuronium or vecuronium (2 x ed90). we also compared the duration of relaxation after intubation and maintenance doses of each drug. | 1997 | 9407675 |
| evoked facial nerve emg and brainstem auditory evoked potential monitoring in cerebellopontine angle tumor resection. | the preservation of normal nerve function or identification of nerve route is critical in some surgeries of cerebellopontine angle tumors. over the last 5 years, intraoperative facial nerve electromyogram (emg) and brainstem auditory evoked potential (baep) were applied for evaluation of facial nerve integrity and brainstem function in patients while undergoing resection of cerebellopontine angle (cpa) tumor. this report represents the retrospective analysis of our results. | 1997 | 9407677 |
| lymph node involvement and tumor depth in rectal cancers: an analysis of 805 patients. | superficial rectal tumors are said to involve regional lymph nodes rarely. this presumption must be proven beyond any doubt if less radical surgery is to be offered for such patients. | 1997 | 9407987 |
| first-line chemotherapy improves the resection rate and long-term survival of locally advanced (t4, any n, m0) squamous cell carcinoma of the thoracic esophagus: final report on 163 consecutive patients with 5-year follow-up. | the objective of this prospective, nonrandomized study was to evaluate the immediate and long-term results of first-line chemotherapy and possible surgery in locally advanced, presumably t4 squamous cell esophageal cancer. | 1997 | 9409570 |
| [course and prognosis of levels of cd4 molecules in hiv-infected patients]. | to measure cd4 molecule concentration on lymphocyte surface. and observe its evolution during one year, in hiv infected patients. to assess the importance of this measure as a prognostic marker for disease progression, compared with the total number of cd4 lymphocytes. | 1997 | 9410120 |
| [measuring vibrations of transport stress in premature and newborn infants during incubator transport]. | despite increasing numbers of centers for perinatology, transportation of newborns and premature infants can not totally be avoided for several obvious reasons. the following investigations were carried out as part of our quality control measures of the established neonatal transportation system, and were aimed on the optimization of a new neonatal transportation equipment resulting in reduction of transportation stress caused by acceleration forces. | 1997 | 9411041 |
| [treatment of planocellular carcinoma of the nasal vestibule]. | in the icd-9 system, carcinomas of the nasal vestibule are classified together with carcinomas in the nasal cavity. as a rule, however, they are squamous cell carcinomas derived from the skin, and thus prognosis is better than in the case of squamous cell carcinomas derived from the mucosa of the nasal cavity. the article highlights essential features of brachytherapy. the authors present a critical assessment of the criteria for staging, and describe a specific patient material. based on clinic ... | 1997 | 9411856 |
| thermal unfolding of bacteriophage t4 short tail fibers. | the short tail fibers of bacteriophage t4 are composed of a homotrimer of the product of gene 12 (p12) with a molecular weight of 165,000. p12 is capable of reconstituting defective phage particles lacking gene 12. after heating to 75 degrees c, p12 was able to retain 90% of its ability to reconstitute t412- particles. when heated above 75 degrees c, p12 was no longer capable of fully reconstituting defective phage particles. by 95 degrees c, the reconstitution efficiency of the p12 preparation ... | 1997 | 9413141 |
| selenium and iodine deficiencies: effects on brain and brown adipose tissue selenoenzyme activity and expression. | adequate dietary iodine supplies and thyroid hormones are needed for the development of the central nervous system (cns) and brown adipose tissue (bat) function. decreases in plasma thyroxine (t4) concentrations may increase the requirement for the selenoenzymes types i and ii iodothyronine deiodinase (id-i and id-ii) in the brain and id-ii in bat to protect against any fall in intracellular 3,3',5 tri-iodothyronine (t3) concentrations in these organs. we have therefore investigated selenoenzyme ... | 1997 | 9415060 |
| divergent deiodination of thyroid hormones in the separated parts of the fetal and maternal placenta in pigs. | previous work from this laboratory has shown that the thyroid gland of the fetal pig begins to function at about day 46-47 (0.40-0.415 fraction of gestational age). sera from fetuses contain lower thyroxine (t4), 3,3',5-triiodothyronine (t3) and 3,3',5'-triiodothyronine (rt3) concentrations than maternal sera, except for about 2 weeks before term. the fetal t4 metabolism is dominated by the 5'-monodeiodinating activity (5'-md). in the present study we measured the iodothyronines content, and the ... | 1997 | 9415064 |
| induction of mutagenic dna damage in human fibroblasts after exposure to artificial tanning lamps. | there is increasing concern about the adverse health effects associated with the use of sunbeds, particularly with respect to skin photocarcinogenesis. the induction of mutagenic dna damage is a prerequisite for the development of skin tumours, and it is well established that direct types of damage such as cyclobutane pyrimidine dimers (cpds) give rise to mutations in tumour suppressor genes and oncogenes. in addition, ultraviolet radiation may induce indirect types of dna damage, including oxid ... | 1997 | 9415225 |
| cold-adapted microtubules: characterization of tubulin posttranslational modifications in the antarctic ciliate euplotes focardii. | in cold poikilotherm organisms, microtubule assembly is promoted at temperatures below 4 degrees c and cold-induced depolymerization is prevented. on the basis of the results of investigations on cold-adapted fishes, the property of cold adaptation is ascribed to intrinsic characteristics of the tubulins. to fully understand cold adaptation, we studied the tubulins of euplotes focardii, an antarctic ciliated protozoan adapted to temperatures ranging from -2 to +4 degrees c. in this organism, we ... | 1997 | 9415375 |
| sympathovagal effects of spinal anesthesia assessed by the spontaneous cardiac baroreflex. | the changes in sympathovagal balance induced by spinal anesthesia remain controversial. the spontaneous baroreflex method allows the continuous assessment of the spontaneous engagement of the cardiac baroreflex, giving an index of sympathovagal balance. the purpose of this study was to follow the effects of spinal anesthesia on spontaneous baroreflex sensitivity. | 1997 | 9416721 |
| effects of proton pump inhibitors on thyroid hormone metabolism in rats: a comparison of udp-glucuronyltransferase induction. | the effects of proton pump inhibitors on thyroid hormone metabolism in rats were examined. pantoprazole, omeprazole, and lansoprazole were administered repeatedly to female sd rats at doses of 5, 50, and 300 mg/kg/day for 1 week, and changes in udp-glucuronyltransferase activities were examined. increases in o-aminophenol udp-glucuronyltransferase activity, which was measured as that responsible for the glucuronidation of thyroxine, were evident following 7-day high-dose administration of all th ... | 1997 | 9416973 |
| isolation and characterization of the phage t4 pina protein, an inhibitor of the atp-dependent lon protease of escherichia coli. | the bacteriophage t4 pina protein, expression of which leads to inhibition of protein degradation in escherichia coli cells, has been purified from cells carrying multiple copies of the pina gene. pina is a heat-stable protein with a subunit mr of 18,800 and an isoelectric point of 4.6. under nondenaturing conditions on a gel filtration column, pina migrated in two peaks corresponding to a dimer and a tetramer. purified pina inhibited atp-dependent protein degradation by lon protease in vitro; i ... | 1998 | 9417110 |
| pina inhibits atp hydrolysis and energy-dependent protein degradation by lon protease. | the bacteriophage t4 pina protein inhibited degradation of [3h]alpha-methyl casein by purified lon protease from escherichia coli, but inhibition was noncompetitive with respect to casein. pina did not inhibit cleavage of the fluorogenic peptide, n-glutaryl-alanylalanylphenylalanyl-3-methoxynaphthylamide and, moreover, did not block the ability of protein substrates, such as casein, to activate cleavage of fluorogenic peptides by lon. thus, pina does not block the proteolytic active site or the ... | 1998 | 9417111 |
| an e. coli b mutation, rpob5081, that prevents growth of phage t4 strains defective in host dna degradation. | an e. coli b tab strain, em121, was isolated that restricts t4 dena (dna endonuclease ii) mutants at 37 degrees c and above, but is permissive for wild-type t4 at all temperatures examined. at 42 degrees c, other mutants affected in nucleic acid metabolism (t4 dexa, rega and uvsw strains) are also restricted. genetic analysis revealed that one mutation (rpob5081) in the rna polymerase beta subunit gene is sufficient for restricting all dena mutants. rpob5081, together with a second linked mutati ... | 1997 | 9418245 |
| altered binding of serum thyroid hormone to thyroxine-binding globulin in women with functional hypothalamic amenorrhea. | to further characterize hypothyroidemia with decreased serum concentrations of total triiodothyronine and total t4 in women with functional hypothalamic amenorrhea. | 1997 | 9418685 |
| studies on rat thyroid after oral administration of mancozeb: morphological and biochemical evaluations. | mancozeb, an ethylenebisdithiocarbamate (ebdc), has been studied for its effects on rat thyroid. single oral administration of mancozeb at different concentrations (9600, 12,000, 15,000 and 18,750 mg kg(-1) body wt) has derived the oral ld50 value as 15,000 mg kg(-1) body wt. in male rats. mancozeb at repeated oral doses of 500, 1000 and 1500 mg kg(-1) day(-1) for periods of 30, 90, 180 and 360 days has produced dose-dependent signs of toxicity and death of animals. the fungicide caused a signif ... | 1997 | 9418944 |
| undifferentiated carcinoma of nasopharyngeal type of the laryngopharyngeal region. | undifferentiated carcinoma of nasopharyngeal type (lymphoepithelioma) is an extremely rare malignancy in the laryngohypopharyngeal region. we found reports of only 13 such tumors in the english language literature. we present the findings of four additional cases, one hypopharyngeal and three laryngeal in origin. the three laryngeal tumors were characterized by submucosal spread. the tumors were classified t3 (2x) and t4 (2x) with cervical lymph node metastases at initial presentation in all cas ... | 1997 | 9419099 |
| inhibition of human cytomegalovirus dna maturation by a benzimidazole ribonucleoside is mediated through the ul89 gene product. | 2-bromo-5,6-dichloro-1-beta-d-ribofuranosyl benzimidazole (bdcrb) is a member of a new class of benzimidazole ribonucleosides which inhibit human cytomegalovirus (hcmv) late in the replication cycle without inhibiting viral dna synthesis. we show here that polygenomic concatemeric hcmv dna does not mature to unit genome length in the presence of bdcrb. to discover the locus of action, virus resistant to bdcrb was selected by serial passage in the presence of the compound. genetic mapping experim ... | 1998 | 9420278 |
| effects of thyroid hormone administration and estrogen deficiency on bone mass of female rats. | to investigate the effects of thyroxine (t4) administration on bone mass, five 81-day-old female rats were treated with t4 (25 microg of t4/100 g of body weight [bw]/day), and bone mineral density (bmd) was measured by dual-energy x-ray absorptiometry (dxa) 28 days later. the bmd values for the total skeleton, femoral, and tibial subsegments were lower than in controls (p < or = 0.05). the lumbar spine (l2-l5) was not significantly affected by t4 treatment. next, thirty-seven 211 +/- 1.5 (mean + ... | 1997 | 9421243 |
| increased spasticity in a chronic spinal cord injury patient after scabies infestation: a case report. | spasticity is a common feature of spinal cord injury (sci). spasticity exacerbation is commonly encountered with nociceptive and exteroceptive stimuli including bladder and bowel dysfunction, pressure sores, contracture, tight-fitting leg bags and clothing, and ingrown toenail. this report describes a patient with chronic sci (t4 level) who complained of increasing spasticity of bilateral lower extremities for 5 weeks. he also had skin lesions on different parts of his body, accompanied by itchi ... | 1997 | 9421996 |
| [results of resected lung cancer based on the new uicc tnm classification, 5th edition]. | the uicc (union internationale contre le cancer) tnm classification for lung cancer staging, 5th edition, has been published this year in accordance with the regulations following the last 10 years of the 4th edition's in use since 1987. what is new in this latest edition is that stage i and ii became classified as ia and ib, and iia and iib respectively. furthermore, the new mode of classification can be found in that t3n0m0 is now acknowledged as of iib, and t4 in such case where the pulmonary ... | 1997 | 9422076 |
| prognostic significance of cell proliferation markers and dna-ploidy in head and neck tumors. | the purpose of this study was to evaluate the prognostic significance of cell proliferation markers and dna ploidy in patients with a squamous cell carcinoma of the head and neck region. | 1998 | 9422554 |
| efficacy of radiochemotherapy with platin derivatives compared to radiotherapy alone in organ-sparing treatment of bladder cancer. | presently, for muscle-invasive bladder cancer, radical cystectomy is considered to be the standard treatment. bladder preservation, in the interest of quality of life, is secondary to the primary treatment goal of curing the patient. we present a 14-year multivariate analysis of prognostic factors influencing survival and bladder preservation after transurethral resection of the bladder (turb) and radiotherapy (rt) +/- chemotherapy. | 1998 | 9422567 |
| emergence times from xenon anaesthesia are independent of the duration of anaesthesia. | xenon (mac = 71%) has an extremely low blood:gas partition coefficient (0.14). therefore, we predicted that the rate of emergence from xenon anaesthesia would not be affected greatly by duration of anaesthesia. we studied 54 asa i-ii patients undergoing lower abdominal surgery who received equal mac anaesthesia with 60% xenon, 60% nitrous oxide with 0.5% isoflurane or 60% nitrous oxide with 0.7% sevoflurane (n = 18 per group), each supplemented with extradural mepivacaine anaesthesia. duration o ... | 1997 | 9422897 |
| treatment duration as a prognostic factor for local control and survival in epidermoid carcinomas of the tonsillar region treated by combined external beam irradiation and brachytherapy. | we wanted to study the influence of the time factor in a combination of external irradiation and brachytherapy from a retrospective study of 370 squamous cell carcinomas of soft palate and tonsil. | 1997 | 9424004 |
| myocardial damage does not occur in untreated hyperthyroidism unless associated with congestive heart failure. | even in the absence of underlying cardiac disease, hyperthyroidism has seldom been reported to be associated with left ventricular dysfunction and congestive heart failure. the left ventricular function invariably improves with achievement of euthyroid status. anecdotal autopsy reports have suggested that myocardial necrosis associated with hyperthyroidism may be responsible for congestive heart failure. this study prospectively evaluates the role of myocardial necrosis in untreated hyperthyroid ... | 1997 | 9424076 |
| [exclusive radical radiotherapy of laryngeal tumors: 10-year experience]. | exclusive irradiation is used to treat primary neoplasms localized to the larynx because it is known to be able to cure, or at least control, the disease in a high percentage of cases without affecting speech. we report our ten-year experience in the radiotherapy department of chieti hospital. from 1985 to 1994, exclusive radiotherapy was used to treat 87 patients bearing histologically proved epidermoid carcinomas of the larynx. the patients average age was 67 years. the primary site was the gl ... | 1997 | 9424659 |
| bending and circularization of site-specific and stereoisomeric carcinogen-dna adducts. | the potent tumorigen and mutagen (+)-7(r),8(s)-dihydroxy-9(s), 10(r)-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene ((+)-anti-bpde) is a metabolite of benzo[a]pyrene that binds predominantly to the exocyclic amino group of guanine residues in dna in vivo and in vitro. while the (-)-7s,8r,9r,10senantiomer, (-)-anti-bpde, also reacts with dna to form similar covalent n2-deoxyguanosyl adducts, this diol epoxide is nontumorigenic and its mutagenic activities are different from those of (+)-anti-bpde. in th ... | 1998 | 9425101 |
| molecular cloning and sequence analysis of chicken type i deiodinase cdna: expression in normal and dwarf broiler chickens. | a cdna encoding the chicken type i iodothyronine deiodinase (cdi-1) was isolated and sequenced from a cdna library prepared from cona-activated chicken splenic t-lymphocytes. the coding region of cdi-1 cdna is composed of 738 basepairs (bp) which encodes a 246 amino acid protein. the predicted amino acid sequence of cdi-1 indicates only 60% identity to several mammalian type i deiodinases. the cdi-1 cdna contains a codon for a highly conserved selenocysteine residue (cys124). northern blot analy ... | 1997 | 9425292 |
| increased thyrotrophin levels and loss of the nocturnal thyrotrophin surge in sheehan's syndrome. | since panhypopituitarism in patients with sheehan's syndrome is due to massive pituitary necrosis with only minor hypothalamic involvement, we hypothesized that serum tsh levels would be low but its circadian rhythm preserved in these patients. | 1997 | 9425390 |
| prospective study of bone loss in pre- and post-menopausal women on l-thyroxine therapy for non-toxic goitre. | hyperthyroidism is associated with increased bone turnover and bone resorption, but the effects of suppressive doses of thyroxine in treating non-toxic goitre remain unclear. we carried out a longitudinal study to evaluate the effect on bone of l-thyroxine (l-t4) therapy in women with non-toxic goitre. | 1997 | 9425392 |
| thyrotrophin and prolactin release in prolonged critical illness: dynamics of spontaneous secretion and effects of growth hormone-secretagogues. | infusion of gh secretagogues appears to be a novel endocrine approach to reverse the catabolic state of critical illness, through amplification of the endogenously blunted gh secretion associated with a substantial igf-i rise. here we report the dynamic characteristics of spontaneous nightly tsh and prl secretion during prolonged critical illness, together with the concomitant effects exerted by the administration of gh-secretagogues, gh-releasing hormone (ghrh) and gh-releasing peptide-2 (ghrp- ... | 1997 | 9425400 |
| increased drug reactions in hiv-1-positive patients: a possible explanation based on patterns of immune dysregulation seen in hiv-1 disease. the military medical consortium for the advancement of retroviral research (mmcarr). | drug reactions are common in hiv-1 disease, with the incidence having been reported to increase with increasing stage and with cd4+ t-cell counts below 200/microliters. however, there have been numerous reports of patients in which rechallenge, dosing changes or continued therapy have resulted in no recurrence or else clearing of the eruption. we followed 974 hiv-1-positive patients for 46 months as a part of a military study of hiv-1 disease. within this group there were a total of 283 drug eru ... | 1997 | 9425690 |
| changes of insulin and somatostatin and their relationship to liver regeneration in experimental obstructive jaundice. | the liver is a parenchymal organ that has a substantial capacity to regenerate after damage. obstructive jaundice is a common surgical disease and potentially risky. a successful outcome of operations depends upon the hepatic regeneration reserve. insulin is one of factors responsible for hepatotrophic regeneration and somatostatin has a reversal suppressive action. experimental obstructive jaundice was introduced and relieved. in addition, serum insulin and somatostatin concentrations were meas ... | 1997 | 9425863 |
| cleavage effect of oligoribonucleotides substituted at the cleavage sites with modified pyrimidine- and purine-nucleosides. | the precursor of an rna molecule from t4-infected e. coli cells (p2spl rna) has the capacity to cleave itself at specific positions [upa (139-140) and cpa (170-171)], within a putative loop and stem structure. this sequence-specific cleavage requires at least a monovalent cation and non-ionic detergents. in order to determine the influence of the pyrimidine and purine bases on these sequence-specific cleavage reactions, we studied the cleavage reactions of hairpin loop rnas substituted at the cl ... | 1997 | 9427530 |
| site-specific repair of cyclobutane pyrimidine dimers in a positioned nucleosome by photolyase and t4 endonuclease v in vitro. | since genomic dna is folded into nucleosomes, and dna damage is generated all over the genome, a central question is how dna repair enzymes access dna lesions and how they cope with nucleosomes. to investigate this topic, we used a reconstituted nucleosome (hisat nucleosome) as a substrate to generate dna lesions by uv light (cyclobutane pyrimidine dimers, cpds), and dna photolyase and t4 endonuclease v (t4-endov) as repair enzymes. the hisat nucleosome is positioned precisely and contains a lon ... | 1998 | 9427764 |
| squamous cell carcinoma of the maxillary sinus treated with radiation therapy and conservative surgery. | for patients with squamous cell carcinoma of the maxillary sinus, combined modality treatment is usually employed, involving radiation and en bloc radical surgery. in this study, local control was analyzed retrospectively in patients who underwent less aggressive piecemeal surgery. | 1998 | 9428485 |
| cancer of the penis--a review of 50 patients. | we reviewed the management of 50 patients with cancer of the penis treated between november 1983 and april 1995 at tygerberg hospital. the mean patient age was 54 years. the race of the patient was mixed in 40, white in 8 and black in 2 cases. serological tests were positive for syphilis in 8/18 (44%), and for human immunodeficiency virus (hiv) in 2/11 patients (18%) who were tested. only 1 patient had been circumcised (at puberty). penectomy was performed in 45 patients--partial amputation in 2 ... | 1997 | 9429328 |
| changing concepts in the diagnosis and management of thyroid nodules. | thyroid nodules are extremely common, affecting from 4% to 7% of the population. fine-needle aspiration biopsy is the most accurate and cost-effective technique for nodule diagnosis. it is simple, safe, and should be the first test used in patient work-up. routine thyroxine (t4) suppressive therapy is no longer recommended for cytologically benign nodules. t4 suppression can cause or aggravate osteoporosis, especially in postmenopausal women. new data on t4 suppressive therapy, cost analysis, an ... | 1997 | 9429860 |
| altered thyroid axis function in lewis rats with genetically defective hypothalamic crh/vp neurosecretory cells. | lewis rats display hyporesponsive hypothalamo-pituitary-adrenocortical (hpa) axes, overproduction of cytokines, and susceptibility to inflammatory disease. the lewis corticotropin-releasing hormone (crh) neurosecretory system contains normal numbers of vasopressin (vp)-deficient axon varicosities, but abnormally sparse vp-containing varicosities in the external zone of the median eminence, compared to the normoresponsive sprague dawley (sd), wistar and fischer 344 strains. since vp may act as a ... | 1997 | 9430824 |
| thyroid hormone concentrations and skeletal muscle metabolism during exercise in anorexic females. | food restriction has been shown to result in an impairment of thyroid status, as the body attempts to conserve energy. in turn, hypothyroidism has been associated with impaired oxidative muscle metabolism, which could negatively affect one's ability to perform exercise. the purpose of this study was to examine the relationship between thyroid status and muscle metabolism during exercise in anorexic (n = 8) and control (n = 13) female subjects. thyroid status was evaluated by measuring resting se ... | 1997 | 9431443 |
| intelligibility and perceptual ratings after treatment for laryngeal cancer: laryngectomy versus radiotherapy. | in sweden the most common treatment for t3-t4 laryngeal carcinoma is radical radiotherapy (with surgery for salvage), because the voice is thus preserved. a swedish study showed that surgery yielded a significantly better 5-year survival and locoregional control at 3 years in t4 laryngeal carcinoma than radical radiotherapy. with these results in mind, we wanted to compare the different modes of treatment (surgery with a tracheoesophageal [te] fistula and radical radiotherapy) with respect to th ... | 1998 | 9432084 |
| [neoadjuvant chemotherapy and chemoradiotherapy in locally advanced stage iiia and iiib of non-small-cell bronchial carcinoma (the essen concept)]. | induction chemotherapies followed by concurrent chemoradiotherapy and definitive surgery have been tested in essen since 1991 in a large phase-ii study for patients with locally (far) advanced non-small cell lung cancer (nsclc) stages iiia (n2) and iiib (t4, n3). after a median follow-up time of 43 months, mature long-term survival data for this intensive multimodality treatment program can now be reported. with nearly 1/3 of these patients experiencing long-term survival at 4 and 5 years after ... | 1997 | 9432686 |
| the myxoma virus m-t4 gene encodes a novel rdel-containing protein that is retained within the endoplasmic reticulum and is important for the productive infection of lymphocytes. | to investigate the contribution of the myxoma virus m-t4 gene to viral virulence, both copies of the m-t4 gene were inactivated by disruption and insertion of the escherichia coli guanosine phosphoribosyltransferase gene. infection of european rabbits with the recombinant m-t4-deleted virus, vmyxlact4, resulted in disease attenuation. in contrast, infection of rabbits with vmyxlac elicited the classical features of lethal myxomatosis. a notable decrease in the number of secondary lesions in anim ... | 1997 | 9434727 |
| thyroglobulin peptides of specific primary hormonogenic sites can generate cytotoxic t cells and serve as target autoantigens in experimental autoimmune thyroiditis. | previously we demonstrated that thyroxine (t4)-containing, 12-mer peptides from positions 5 (1-12) and 2553 (2549-2560), as well as thyronine (t0)-substituted 2553 peptide, derived from human (h) thyroglobulin (tg) are capable of activating t cells that infiltrate the thyroid (thyroiditogenic). in contrast, peptides t4(2567) and t0(2567) (2559-2570) are not. to determine if these thyroiditogenic peptides, t4(5), t4(2553), and t0(2553), activated cytotoxic t cells (tc) and served as target autoan ... | 1998 | 9434803 |
| the antidepressant fluvoxamine increases natural killer cell counts in cancer patients. | knowing the negative effect of depression on lymphocyte number and activity in humans, we investigated the effect of antidepressant therapy on various lymphocyte subgroups. cancer patients receiving treatment for at least 6 months were asked to take the antidepressant, fluvoxamine, for 28 days. before and at the end of the study, physical and psychiatric examinations were performed, and the severity of depression was assessed by the hamilton scale for depression (ham-d). in addition, a sample of ... | 1997 | 9434807 |
| plasma cholesteryl ester transfer protein activity in hyper- and hypothyroidism. | thyroid dysfunction is associated with multiple changes in lipoprotein metabolism, and we have determined the effects of thyroid dysfunction on plasma cholesteryl ester transfer protein (cetp) activity. cetp is a plasma protein that mediates the exchange of cholesteryl ester and triglyceride between plasma lipoproteins and plays an important role in high-density lipoprotein metabolism and in the reverse cholesterol transport pathway. plasma cetp activity was assayed in 18 hyperthyroid and in 17 ... | 1998 | 9435431 |
| [bilateral breast cancer after hodgkin disease. clinical and pathological characteristics and therapeutic possibilities: an analysis of 13 cases]. | though hodgkin's disease (hd) is one of the malignancies in which considerable progress has been made, long-term side effects have been observed, second primary cancer being the most significant. several recent reports have indicated an increased risk of breast cancer (bc) in girls and young women among hd patients. | 1997 | 9435820 |
| in vitro effects of recombinant human granulocyte-macrophage colony-stimulating factor (rhgm-csf) on polymorphonuclear cell (pmn) and monocyte (mo) functional capacities in ovarian cancer patients versus human volunteers. | human polymorphonuclear cells (pmn) and monocytes (mo) from four ovarian cancer patients and seventeen normal donors were in vitro pretreated with different concentrations (25, 50 and 100 iu, respectively) of rhgm-csf. phagocytosis and killing of pmn and mo as well as pmn polarization were evaluated in cancer patients before treatment (t0) and at the end of each chemotherapeutic cycle (t1, t2, t3 and t4, respectively) in comparison with normal donors. rhgm-csf did not affect phagocytosis and kil ... | 1997 | 9436044 |
| [relationships between selenium deficiency and 3,5,3'-triiodothyronine (t3) synthesis]. | several enzymes, the main being type i 5' deiodinase, ensure thyroxin (t4) into 3,5,3'-triiodothyronine (t3) deiodination, both in the thyroid and in peripheral tissues. one of the feature of this enzymatic reaction is its regulation. it depends in part on individual selenium and iodine status. it has been shown by an analysis of thyroid hormones concentrations variations, when one of these trace elements is missing. during thyroid hormone synthesis, selenium and iodine are also implied in oxida ... | 1997 | 9436480 |
| fetal cord blood sampling in the diagnosis and the treatment of fetal hyperthyroidism in the offsprings of a euthyroid mother, producing thyroid stimulating immunoglobulins. | we described here three individual pregnancies in a euthyroid mother with a past history of graves disease and high levels of thyrotropin receptor stimulating antibodies. ten years prior to her first pregnancy the mother underwent a partial thyroidectomy for graves disease and remained euthyroid since, but still produced high levels of thyrotropin receptor stimulating antibodies. fetal and postnatal hyperthyroidism was not recognized for the first child who was referred to us at one year of age ... | 1997 | 9436485 |
| dietary fatty acids modulate hormone responses in lactating cows: mechanistic role for 5'-deiodinase activity in tissue. | supplemental dietary fat provides excess fatty acids (fa), which can alter circulating concentrations of several hormones. to test the effects of fatty acid isomer type and possible sites of regulation, we abomasally infused fat mixtures high in cis-c18:1 fa (icis), high in trans-c18:1 fa (itrs) or no infusion (ni) and performed intravenous arginine (arg) and intramuscular thyrotropin-releasing hormone (trh) challenges. the experimental design was a replicated 3 x 3 latin square. challenges were ... | 1997 | 9437577 |
| recombinant porcine leptin reduces feed intake and stimulates growth hormone secretion in swine. | two experiments (exp) were conducted to test the hypothesis that porcine leptin affects gh, insulin-like growth factor-i (igf-i), insulin, thyroxine (t4) secretion, and feed intake. in exp i, prepuberal gilts received intracerebroventricular (i.c.v.) leptin injections. blood was collected every 15 min for 4 hr before and 3 hr after i.c.v. injections of 0.9% saline (s; n = 3), 10 micrograms (n = 4), 50 micrograms (n = 4), or 100 micrograms (n = 4) of leptin in s. pigs were fed each day at 0800 an ... | 1998 | 9437587 |
| transient hypothyroidism reinitiates egg laying in turkey breeder hens: termination of photorefractoriness by propylthiouracil. | a study was conducted to determine the effects of transient hypothyroidism induced by propylthiouracil (ptu) on termination of photorefractoriness and reinitiation of lay in turkey breeder hens. the ptu was given for 6- or 8-wk periods via the feed and at various doses to yearling hens that had been continuously exposed to long photoperiods [16 h light (l):8 h dark (d)] for at least 25 wk. there was a dose-dependent cessation of lay as well as deletion of thyroxine (t4) and triiodothyronine (t3) ... | 1997 | 9438295 |
| late and transient increases in free t4 after radioiodine treatment for graves' disease. | the objective of this retrospective study was to evaluate the fall in free t4 (ft4) in patients with graves' disease after treatment with radioiodine in a fixed dose of 600 mbq. the study was performed at our outpatient clinic with patients referred from primary care during the time period january 1989 to january 1995. only patients not given anti thyroid drugs after radioiodine were included. ft4 and tsh were measured every second week for the first three months, and thyroxine substitution star ... | 1997 | 9438914 |
| prognostic factors in squamous cell carcinoma of the penis and implications for management. | to determine the clinical and pathological features, methods and outcome of management in squamous cell carcinoma of the penis (sccp). | 1997 | 9439414 |
| influence of imipramine on the hypothalamic/pituitary/thyroid axis of the rat. | the effects of the tricyclic antidepressant drug imipramine at different levels of the hypothalamic/pituitary/thyroid axis were investigated in the rat. intraperitoneal (ip) treatment for 14 days with imipramine at 10 mg/kg, but not 2 mg/kg, reduced serum total thyroxine (t4) and triiodothyronine (t3). a similar decrease in serum total t4 was observed in thyroidectomized t4-treated rats, suggesting that imipramine treatment enhances t4 clearance instead of reducing t4 secretion. there were no pa ... | 1997 | 9439538 |
| peripheral afferent stimulation of decentralized sympathetic neurons activates lipolysis in spinal cord-injured subjects. | spinal cord-injured (sci) subjects exhibit a normal lipolytic rate despite the failure of centrally mediated sympathoexcitatory stimuli to activate lipolysis. peripheral afferent stimulation below the lesion level induces an exaggerated autonomic reaction in sci with lesion levels above t5, ie, so-called autonomic dysreflexia. the metabolic effects of induced dysreflexia were investigated in five sci subjects (age, 35 +/- 8 years; duration of paresis, 15 +/- 7.5 years [mean +/- sd]; lesion level ... | 1997 | 9439544 |
| isolation and characterization of ems induced splicing defective point mutations within the intron of the nrdb gene of bacteriophage t4. | the nrdb gene of bacteriophage t4 codes for the small subunit of ribonucleotide reductase and contains a 598-base-pair self-splicing intron which is closely related to other group i introns of t4 and eukaryotes. the screening, isolation, and mapping of 31 nrdb intron mutations were conducted by the strategic usage of the white halo phenotype exhibited by t4 mutants defective in dyhydrofolate reductase or thymidylate synthase. these intron mutations cluster towards the ends, mainly the 3' end, an ... | 1998 | 9439601 |
| inhibitory regulation of inhibin gene expression by thyroid hormone during ovarian development in immature rats. | to explore the role of the thyroid gland in ovarian development during the initiation process of puberty, we examined the effects of hypothyroidism on the secretion of ovarian hormones during equine chorionic gonadotropin (ecg)-induced follicle development in immature female rats. immature rats at 22 days of age were thyroidectomized (tx) to cause hypothyroidism and then given a single s.c. injection of 5 iu ecg at 26 days of age to induce normal first ovulation. the blood samples were collected ... | 1998 | 9439618 |
| congenital hyperthyroidism. | congenital hyperthyroidism is a very rare disease. but, for each affected child it has to be considered as a serious condition because of the negative impact of hyperthyroidism on fetal and postnatal development. if the manifestation occurs during fetal life tachycardia, cardiac arrhythmia, growth retardation and, most significant, prematurity are the consequences. postnatal signs of hyperthyroidism are irritability, tachycardia, hypertension, poor weight gain and thyroid enlargement. even cardi ... | 1997 | 9439907 |
| thyroid function in preterm newborns; is t4 treatment required in infants < 27 weeks' gestational age? | thyroid hormones are essential for brain maturation. very preterm infants, who are at risk of neurodevelopmental disabilities also have low t4 and ft4 values in the first weeks after birth. this transient hypothyroxinemia may in part be causal to the neurodevelopmental problems. we have carried out a randomised, double-blind, placebo-controlled trial with t4 in 200 infants < 30 weeks' gestation. in the study groups as a whole (n = 100 in the t4 group, n = 100 in the placebo group), no clear effe ... | 1997 | 9439908 |
| epidemiology of congenital hypothyroidism. | according to world-wide data obtained from neonatal thyroid screening programs congenital hypothyroidism (ch) occurs with an incidence of 1:3000 to 1:4000. differences of ch-incidence are more likely due to iodine deficiency thyroid disorders or to the type of screening method than to ethnic affiliation. ch is caused by an absent or defective thyroid gland classified into agenesis (22-42%), ectopy (35-42%) and gland in place defects (24-36%). although a few cases of thyroid dysgenesis have been ... | 1997 | 9439909 |
| results of the screening program for congenital hypothyroidism in berlin (1978-1995). | screening for congenital hypothyroidism for all newborns of the former western parts of the city of berlin was instituted in 1978 by determination of the tsh levels in dried filter paper blood spots of the 3rd to 5th day of life. since 1991 the newborns of the former eastern parts have been also included in the same screening program. from 1978 to 1995 a total number of 104 newborns with permanent congenital hypothyroidism have been detected resulting in a prevalence of congenital hypothyroidism ... | 1997 | 9439911 |
| serum androgen levels in hyperthyroid women. | thyroid hormone is known to affect androgen metabolism, however, there are few studies in which alterations of androgen metabolism are simultaneously examined in patients with clinical thyroid disorders. in this study, we investigated the alterations of thyroid hormone and androgens before and during treatment in patients with hyperthyroidism. fifteen female patients with hyperthyroidism due to graves' disease were studied. from these patients, blood samples were obtained before treatment and at ... | 1997 | 9439933 |
| d-thyroxine reduces lipoprotein(a) serum concentration in dialysis patients. | uremia raises lipoprotein(a) (lp(a)) serum concentration and the risk of arteriosclerosis in dialysis patients. the treatment of high lp(a) levels is not satisfactory today. the decrease of lp(a) in hypothyroid patients on l-t4 therapy raised the question of whether dextro-thyroxine (d-thyroxine) reduces not only serum cholesterol, but also lp(a) serum concentration. in a single-blind placebo-controlled study, the influence of d-thyroxine therapy on lp(a) serum concentration was evaluated in 30 ... | 1998 | 9440092 |
| effects of induced hypo- and hyperthyroidism on immune function and plasma biochemistry in mallards (anas platyrhynchos). | hypo- or hyperthyroid states were induced in adult male mallards (anas platyrhynchos) by subchronic exposure to daily injections of methimazole or a 9:1 ratio of thyroxine (t4): triiodothyronine (t3). the levels of t4 given were 0, 125, 250, or 500 micrograms/kg/day and for methimazole; 10 mg/kg/day for 22 or 21 days. plasma t3 showed a lasting decrease with t4:t3 treatment, despite the attempt to maintain the normal t4:t3 ratio. antibody formation to sheep red blood cells was decreased only at ... | 1997 | 9440248 |
| delta-aminolevulinic acid-induced fluorescence in normal human lymphocytes. | endogenously generated protoporphyrin ix (ppix) from exogenous delta-aminolevulinic acid (ala) has the photodynamic capacity to inactive cancer cells of different origins. the aim of this study was to characterize the ability of normal lymphocytes to transform ala into ppix in order to appreciate through further studies changes in pathologic lymphocytes. we investigated in this study ppix synthesis by normal human lymphocytes using a confocal laser microspectrofluorometer. live lymphocytes were ... | 1997 | 9440310 |
| posttraumatic syringomyelia: profound neuronal loss, yet preserved function. | posttraumatic syrinxes may extend many cord segments rostral to a spinal cord injury (sci) and significantly dilate the spinal cord, yet few neurologic deficits may be noted. careful physical examination may reveal ascending loss of pain and temperature without evident functional motor decline. we present a 49-year-old man with t4 paraplegia and a large posttraumatic syrinx who died 3 weeks after syringoperitoneal shunting. neuropathologic study revealed a large bilateral syrinx cavity from t1 t ... | 1998 | 9440427 |
| [transfer and metabolism of thyroid gland hormones in the placenta]. | the human placenta is an important link in the maternal-fetal communication network for thyroid hormones which are essential for the normal development and differentiation of the fetus. the placenta transports and metabolizes maternal thyroid hormones. there is also evidence for transfer of fetal thyroid hormones or their metabolites into the maternal circulation. the placenta mainly expresses 5-deiodinase activity (type iii), which inactivates t4 and other iodothyronines and thus limits the tra ... | 1997 | 9441548 |
| effects of the antipsychotic drug sulpiride on reproductive hormones in healthy premenopausal women: relationship with body weight regulation. | metabolic and endocrine abnormalities secondary to hyperprolactinemia, such as hypogonadism and hyperandrogenicity, may be involved in the excessive body weight gain induced by antipsychotic drugs in women. the present study was conducted in healthy premenopausal women, in order to detect an endocrine imbalance secondary to antipsychotic drug administration, which, if sustained in the long term, might be involved in the development of obesity. after a control menstrual cycle, sulpiride (200 mg/d ... | 1997 | 9442548 |
| repair of degraded duplex dna from prehistoric samples using escherichia coli dna polymerase i and t4 dna ligase. | the most notable feature of dna extracted from prehistoric material is that it is of poor quality. amplification of pcr products from such dna is consequently an exception. here we present a simple method for the repair of degraded duplex dna using the enzymes escherichia coli dna polymerase i and t4 dna ligase. adjacent sequences separated by nicks do not split up into intact strands during the denaturation step of pcr. thus the target dna is refractory to amplification. the proposed repair of ... | 1998 | 9443981 |
| hyperprolactinaemia and galactorrhoea associated with primary hypothyroidism in a bitch. | an endocrinopathy characterised by hyperprolactinaemia and galactorrhoea was found to be associated with primary hypothyroidism in an entire bitch. clinical diagnosis was confirmed by lowered baseline t4 blood levels, reduced response to the thyroid stimulating hormone (tsh) test, elevated prolactin and tsh values, and echographic and scintigraphic examinations. levothyroxine treatment resulted in a clinical improvement (especially of the galactorrhoea), and levels of prolactin, thyroxine, tsh, ... | 1997 | 9444640 |
| effect of glucocorticoid treatment on biochemical and hormonal blood parameters in early pregnant gilts. | twenty polish landrace gilts were grouped immediately after mating as follows: experiment i-- group 1 (5 gilts), control animals and group 2 (5 gilts), injected i.m. with dexamethasone (30 mg/kg) at 12-h intervals from day 13 to day 22 of pregnancy; experiment ii--group 3 (5 gilts), injected i.m. with corn oil from day 13 to day 22 of pregnancy and group 4 (5 gilts), injected i.m. with hydrocortisone acetate (250 mg) at 12-h intervals from day 11 to day 20 of pregnancy. gilts were placed in meta ... | 1997 | 9444780 |
| anterior decompression and fusion via the extrapleural approach for thoracic disc herniation causing myelopathy. | anterior decompression and fusion via an extrapleural approach was performed for 33 patients with myelopathy arising from thoracic disc herniation and the clinical usefulness and problems related to this procedure were assessed on the basis of surgical results and complications. the severity of the myelopathy was evaluated by the japanese orthopaedic association score, and the surgical results were based on the recovery rate. the upper-level limit of decompression and fusion via the extrapleural ... | 1997 | 9444928 |
| t classification and clivus margin as risk factors for determining locoregional control by radiotherapy of nasopharyngeal carcinoma. | the purpose of this study was to determine risk factors that affect locoregional control of nasopharyngeal carcinoma (npc) after radiotherapy. computed tomography (ct) is utilized for radiotherapy planning and for identifying high risk anatomic areas. | 1998 | 9445180 |
| [neoadjuvant chemotherapy in the treatment of breast cancer. results and prospectives]. | preoperative chemotherapy for breast cancer has been originally proposed in the treatment of locally advanced tumors (t3b-t4) in order to allow radiotherapy or radical mastectomy. later, it has been employed also for less advanced stages of the disease (t2-t3), to allow conservative surgery. personal series of 45 patients that underwent preoperative chemotherapy (fac) for breast cancer stages t2-t3 is reported. a partial response in terms of reduction of tumor volume was obtained in 80% of these ... | 1997 | 9446073 |
| effects of long-term temperature acclimation on thyroid hormone deiodinase function, plasma thyroid hormone levels, growth, and reproductive status of male atlantic cod, gadus morhua. | the recent collapse of the northwestern atlantic cod fisheries has coincided with a cooling of water temperatures. during this time the condition factor of cod has been poor. the objective of the present study was to determine the effects of long-term temperature acclimation on growth reproduction and thyroid function in laboratory held atlantic cod (gadus morhua). one of the key parameters used to assess thyroid function is the peripheral metabolism of l-thyroxine (t4) by microsomal deiodinase ... | 1998 | 9446719 |
| combined radiochemotherapy for organ preservation in head and neck cancer: review of literature and personal experience. | combined radiochemotherapy is the most common method aimed at improving the rate of clinical response in advanced head and neck cancer. complete clinical remission may correspond to a significant percentage in organ and/or function preservation. in 1992 a protocol of concomitant radiochemotherapy with continuous infusion of carboplatin for 14 consecutive days at the daily dose of 30 mg/m2 and concomitant radiotherapy with conventional fractionation (1.8 gy to a total 65-70gy) was started. over a ... | 1997 | 9446947 |
| increased urinary thyroxine sulfate excretion in thyroxine therapy. | although increased thyroxine sulfate (t4s) levels have recently been detected in fetal serum and amniotic fluid, changes in patients in a high thyroxine (t4) state remain unclarified. this study was conducted to determine the changes in t4s in thyroid hormone regulation in women receiving suppressive t4 therapy. with a highly sensitive and specific radioimmunoassay, we measured the serum and urinary concentrations of t4s in 16 premenopausal women with benign nodular goiter before and after three ... | 1997 | 9447277 |
| recent trends in the management of graves' hyperthyroidism in japan: opinion survey results, especially on the combination therapy of antithyroid drug and thyroid hormone. | an opinion survey concerning the management of graves' hyperthyroidism was conducted among the council members of the japan thyroid association. the selection of 3 major treatments by 90 respondents for their patients was 98.6 +/- 4.2% for antithyroid drug (atd), 7.8 +/- 12.6% for partial thyroidectomy and 5.2 +/- 8.1% for radioiodide. they expressed a movement away from the past trend of surgery because of postoperative complications and unsatisfactory therapeutic results, and they assumed a fu ... | 1997 | 9447283 |
| thioredoxin from streptomyces aureofaciens controls coiling of plasmid dna. | a number of potential functions of thioredoxin have been proposed in literature, including a role for dna replication. the aim of our study was to investigate the effects of thioredoxin from streptomyces aureofaciens (trx s.a.) on plasmid dna. trx s.a. was incubated with plasmid forms and the incubation product(s) characterized on agarose gels. to compare trx activity with enzymes with known dna modifying activities, topoisomerase i, ii (gyrase) and t4 dna ligase were incubated with plasmid dna ... | 1998 | 9449230 |
| the prognosis of esophageal carcinoma staged irresectable (t4) by endosonography. | endosonography is an accurate preoperative staging technique for esophageal carcinoma. we retrospectively investigated a cohort of patients with carcinoma of the esophagus or gastric cardia that was endosonographically staged to be irresectable and studied whether their survival was influenced by the treatment received. | 1998 | 9449596 |
| expression of chicken thyroid-stimulating hormone beta-subunit messenger ribonucleic acid during embryonic and neonatal development. | the importance of thyroid hormone from embryonic through neonatal life has been documented in both avian and mammalian species. however, the regulation of thyroid hormone production during this period is not completely understood. the objective of this study was to characterize expression of chicken tshbeta messenger rna (mrna) compared with that of thyroid hormones and gh in embryonic and neonatal chickens. total pituitary rna was extracted on embryonic days (e-) 11, 13, 15, 17, and 19 and neon ... | 1998 | 9449613 |
| thyroxine 5'-deiodination mediates norepinephrine-induced lipogenesis in dispersed brown adipocytes. | in euthyroid rats, maximal sympathetic nervous system stimulation (e.g. during cold exposure) results in a 3- to 4-fold increase in brown adipose tissue lipogenesis, a response that is blunted in hypothyroid rats. to further investigate this phenomenon, the role of local type ii 5'-deiodinase (5'-dii) was studied in freshly isolated brown adipocytes. in a typical experiment, 1.5 x 10(6) cells were incubated for up to 48 h in a water-saturated 5% co2-95% o2 atmosphere. after incubation with mediu ... | 1998 | 9449627 |
| rapid sulfation of 3,3',5'-triiodothyronine in native xenopus laevis oocytes. | sulfation is an important metabolic pathway facilitating the degradation of thyroid hormone by the type i iodothyronine deiodinase. different human and rat tissues contain cytoplasmic sulfotransferases that show a substrate preference for 3,3'-diiodothyronine (3,3'-t2) > t3 > rt3 > t4. during investigation of the expression of plasma membrane transporters for thyroid hormone by injection of rat liver rna in xenopus laevis oocytes, we found uptake and metabolism of iodothyronines by native oocyte ... | 1998 | 9449630 |
| transcriptional activation of type iii inner ring deiodinase by growth factors in cultured rat brown adipocytes. | the activity of the type iii inner ring deiodinase (diii), which converts t4 and t3 to inactive metabolites, is induced by serum and growth factors in primary cultures of rat brown adipocytes. the contribution of pretranslational mechanisms to this increase in diii activity was examined in the present studies. diii mrna is undetectable in differentiated brown adipocytes when cultured in serum-free medium. however, exposure to epidermal growth factor (egf), acidic or basic fibroblast growth facto ... | 1998 | 9449635 |
| t4 endonuclease vii--a zinc containing four-way dna junction resolving enzyme. | 1997 | 9450072 | |
| a thyroxine-containing thyroglobulin peptide induces both lymphocytic and granulomatous forms of experimental autoimmune thyroiditis. | mouse thyroglobulin (mtg)-sensitized spleen cells activated in vitro with mtg can induce two histologically distinct forms of experimental autoimmune thyroiditis (eat). mtg-sensitized cells activated with mtg alone induce a mild chronic form of eat in which the thyroid infiltrate consists primarily of lymphocytes and other mononuclear cells (lymphocytic eat). the same donor cells activated with mtg and anti-il2r mab induce a more severe and acute form of eat with a thyroid inflammatory lesion ha ... | 1997 | 9451592 |
| pre-operative [correction of properative] psychological variables predict immunological status in patients with operable breast cancer. | in a prospective study of psychobiological responses in patients with operable breast cancer, psychological data were collected one day before surgery and immunological data one day before and seven days after surgery. | 1997 | 9451750 |
| [reactions of non pregnant and and of cattle at different stages of pregnancy from the holstein friesian breed (hf) and from the old type german black and white breed (dsb) exposed to transport stress: variation and individual reaction patterns of hormone metabolic and hematologic variables]. | breeding animal transports between parts of our institute were used assessing effects of age of animals, of breed, of their functional state and of individual specificity of reaction patterns using peripheral venous blood samples. increased mean values of hb, hk, body temperature, total protein, albumin, ft4, t4, ft3, t3, cortisol, adrenaline and decreased ones of body weight, pa, fe, noradrenaline were found after transport stress. comparing age matched groups of dsb and hf breed higher concent ... | 1997 | 9451856 |