Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| [community-acquired pneumonia--pathogens and assessment]. | pneumonia is one of the most important infectious diseases, both in terms of incidence as well as potential severity. streptococcus pneumoniae remains the most prevalent etiologic agent, accounting for about two-thirds of bacteremic cases. diagnostic procedures include chest radiography, blood culture, gram staining and culture of expectorated sputum, urine antigen assays for legionella pneumophila and pneumococci, and asservation of an initial serum sample for comparative serologic investigatio ... | 2001 | 11695086 |
| immune function in swedish élite orienteers. | during 1979-1992 an increased frequency of sudden unexpected cardiac death (sud) occurred among young male swedish élite orienteers. subacute-to-chronic myocarditis was found in 12/16 (75%) at autopsy and chlamydia pneumoniae, or a cross-reacting agent, was suspected on the basis of diagnostic tests performed. because myocarditis is an infrequent cause of sud and clusters of sud are rare, whereas chlamydia pneumoniae infections are ubiquitous and seldom cause severe myocarditis, 119 top ranked é ... | 2001 | 11696211 |
| relation of chlamydia pneumoniae infection in taiwan to angiographically demonstrated coronary artery disease and to the presence of acute myocardial infarction or unstable angina pectoris. | reports of the association of chlamydia pneumoniae (c. pneumoniae) infection with coronary artery disease (cad) are scarce in the oriental population. we therefore conducted a case-control study to explore this issue in taiwan. there were 242 consecutive subjects (166 men and 76 women) who underwent cardiac catheterization at the national taiwan university hospital cardiac catheterization laboratory. patients with cad (n = 156) had > or = 1 coronary artery lesion of > 50% diameter stenosis on an ... | 2001 | 11703989 |
| structural analyses of the lipopolysaccharides from chlamydophila psittaci strain 6bc and chlamydophila pneumoniae strain kajaani 6. | lipopolysaccharides (lpss) of chlamydophila psittaci 6bc and chlamydophila pneumoniae kajaani 6 contain 3-deoxy-d-manno-oct-2-ulosonic acid (kdo), glcn, organic bound phosphate, and fatty acids in the molar ratios of approximately 3:2:2.2:4.8 and approximately 2.9:2:2.1:4.9, respectively. the lpss were immunoreactive with a monoclonal antibody against a family-specific epitope of chlamydial lps. this finding, together with methylation analyses of both lpss and maldi-tof ms experiments on de-o-, ... | 2001 | 11705470 |
| chlamydia pneumoniae infects and multiplies in lymphocytes in vitro. | the obligate intracellular pathogen chlamydia (chlamydophila) pneumoniae is known to be associated with some chronic inflammatory diseases, such as atherosclerosis. interaction between c. pneumoniae and immune cells is important in the development of such diseases. however, susceptibility of immune cells, particularly lymphocytes, to c. pneumoniae infection has not been reported, even though lymphocytes play a pivotal role in the development of the diseases caused by this bacterium. in this rega ... | 2001 | 11705957 |
| epithelial cells infected with chlamydophila pneumoniae (chlamydia pneumoniae) are resistant to apoptosis. | the obligate intracellular pathogen chlamydophila pneumoniae (chlamydia pneumoniae) initiates infections in humans via the mucosal epithelia of the respiratory tract. here, we report that epithelial cells infected with c. pneumoniae are resistant to apoptosis induced by treatment with drugs or by death receptor ligation. the induction of protection from apoptosis depended on the infection conditions since only cells containing large inclusions were protected. the underlying mechanism of infectio ... | 2001 | 11705971 |
| koala biovar of chlamydia pneumoniae infects human and koala monocytes and induces increased uptake of lipids in vitro. | we examined the ability of the koala biovar of chlamydia pneumoniae to infect both hep-2 cells and human monocytes and the effect of infection on the formation of foam cells. the koala biovar produced large inclusions in both human and koala monocytes and in hep-2 cells. koala c. pneumoniae induced foam cell formation with and without added low-density lipoprotein, in contrast to tw183, which produced increased foam cell formation only in the presence of low-density lipoprotein. | 2001 | 11705973 |
| characterization of chlamydia pneumoniae persistence in hep-2 cells treated with gamma interferon. | infection with chlamydia pneumoniae has been implicated as a potential risk factor for atherosclerosis. this study demonstrated the effects of gamma interferon (ifn-gamma)-mediated indoleamine 2,3-dioxygenase activity on c. pneumoniae persistence in hep-2 cells, inclusion morphology, and ultrastructure. c. pneumoniae replication showed a dose-dependent decrease when treated with increasing concentrations of ifn-gamma and a phenotypic switch resulting in a decrease in typical inclusions with an i ... | 2001 | 11705979 |
| [the prevalence of chlamydia pneumoniae in respiratory infections in the lower respiratory tracts in children under two]. | 2001 | 11709128 | |
| [importance of chronic bacterial infections for the onset and development of atherosclerosis]. | 2001 | 11712222 | |
| [field epidemiological investigation on an outbreak of chlamydia pneumoniae infection--first recognized incidence in a nursing home for elderly in japan]. | chlamydia pneumoniae (c. pneumoniae) is an emerging pathogen recognized in 1989. although c. pneumoniae infection is known to give a great impact on public health in western countries, many aspects remain unclarified in japan. during december 1999 and march 2000, respiratory symptoms among residents and employees in a nursing home for elderly implicated an outbreak of c. pneumoniae infection. field epidemiological investigation confirmed that this is the first outbreak recognized in a nursing ho ... | 2001 | 11712363 |
| antibiotic therapy in coronary heart disease--where do we currently stand? | a casual association between chlamydia pneumoniae infection and atherosclerosis remains unresolved but plausible. evidence comes from sero-epidemiological data, pathological specimen examinations, animal models and in vitro experiments. a number of prospective antibiotic intervention trials targeted against c. pneumoniae infection in patients with coronary heart disease are now underway. we remain wary that c. pneumoniae infection can persist in cell lines (associated with atherosclerosis) despi ... | 2001 | 11713887 |
| in vitro susceptibility and eradication of chlamydia pneumoniae cardiovascular strains from coronary artery endothelium and smooth muscle cells. | recovery of viable chlamydia pneumoniae from atheromas of coronary heart diseases patients has initiated pilot studies to eradicate c. pneumoniae from vascular tissue by antibiotic treatment. to provide data for the selection of effective antibiotics, we investigated the in vitro activity of anti-chlamydial antibiotics to eliminate vascular strains of c. pneumoniae from coronary endothelial and smooth muscle cells, celltypes that are involved in the pathogenesis of atherosclerosis. | 2001 | 11713894 |
| ifn-alpha beta-dependent, ifn-gamma secretion by bone marrow-derived macrophages controls an intracellular bacterial infection. | several reports have indicated that cell lineages apart from nk and t cells can also express ifn-gamma. however, the biological relevance of this finding is uncertain. we show in this study that bone marrow-derived macrophages (bmms) express ifn-gamma at the mrna and protein level early after infection with chlamydia pneumoniae. increased ifn-gamma mrna accumulation by infected bmms is early, transient, and requires both bacterial and host protein synthesis. the induction of ifn-gamma mrna level ... | 2001 | 11714812 |
| chlamydia pneumoniae--aetiologic agent of what? | 2001 | 11715748 | |
| [chlamydia antibody titers in patients with coronary disease: relations to age and clinical stage]. | background and aim: atherosclerosis and its clinical sequelae are responsible for the highest death rate in industrialized countries. seroepidemiological, pathological and immunohistochemical studies have suggested a relation between chlamydia pneumoniae infection and the development of coronary sclerosis. aim of this study was to investigate the frequency distribution of chlamydia pneumoniae antibody titers in patients with different clinical stages of coronary artery disease (cad) and patients ... | 2001 | 11715750 |
| increase of chlamydial lps antibodies in patients with acute coronary syndrome without detection of chlamydial dna in atherectomy samples. | chlamydia pneumoniae, a respiratory pathogen, has been connected with the pathogenesis of coronary artery disease (cad). previous studies indicated a correlation between antibodies to chlamydial lps and the risk of cardiovascular disease. the aim of this study was to determine whether c. pneumoniae plays a direct role in the pathology of acute coronary syndromes (acs). | 2001 | 11715751 |
| prevention of coronary heart disease through treatment of infection with chlamydia pneumoniae? estimation of possible effectiveness and costs. | evidence has been accumulating for a link between chlamydia pneumoniae and coronary heart disease (chd). a spreadsheet model was used to estimate the impact of different strategies for screening and treating c. pneumoniae on the incidence of myocardial infarction and cardiac mortality over a 1-year post-intervention period. it was found that screening would potentially be most cost-effective in men aged over 35 with a history of myocardial infarction (around ł2,000 per life-year saved). cost-eff ... | 2001 | 11718459 |
| the role of infection in atherosclerosis and coronary artery disease: a new therapeutic target. | there is growing evidence that inflammatory processes may be involved in the development of atherosclerosis and its complications. viral and bacterial pathogens have been implicated as possible causative factors in the pathogenesis of coronary artery disease (cad) and restenosis after angioplasty. antibiotic trials are now in progress to examine whether treatment of infection can prevent the complications of cad. atherosclerosis, the primary pathologic process in coronary artery disease (cad), c ... | 1999 | 11720630 |
| [unrecognized chronic bronchitis]. | 2001 | 11721487 | |
| evidence that chlamydia pneumoniae affects platelet activity in patients with acute myocardial infarction and st-segment elevations. | this study concerns platelet activity at myocardial infarctions and possible relationships with chlamydia pneumoniae seroreactivity. fourteen patients with acute myocardial infarction and st-segment elevations were enrolled. they all received thrombolytic therapy. the subjects were examined within 24 h after hospital admission (day 1) and after 6 months of recovery. on day 1, c. pneumoniae igm antibody titres were analysed and on day 1 and during recovery c. pneumoniae igg and soluble p-selectin ... | 2001 | 11728040 |
| atherosclerosis and tuberculosis: are they both chronic infectious diseases? | 2001 | 11728058 | |
| incidence of immunoglobulin g antibodies to chlamydia pneumoniae in acute myocardial infarction patients. | recent studies have suggested a possible association between chlamydia pneumoniae infection and coronary heart disease. | 2001 | 11729576 |
| prevalence of chlamydia pneumoniae in peripheral blood mononuclear cells in italian patients with acute ischaemic heart disease. | chlamydia pneumoniae infection generally starts in the respiratory tract and probably disseminates systemically in the blood stream within alveolar macrophages. we investigated the prevalence of c. pneumoniae dna in peripheral blood mononuclear cells (pbmc) in patients with acute ischaemic heart disease. samples of blood were obtained from 93 consecutive patients with acute ischaemic heart disease and from 42 healthy subjects, for detection of c. pneumoniae dna in pbmc by polymerase chain reacti ... | 2001 | 11730834 |
| in vitro degradation of aortic elastin by chlamydia pneumoniae. | to investigate whether chlamydia pneumoniae (c. pneumoniae) may increase elastin degradation in the aortic wall. | 2001 | 11735183 |
| prevention and management of infection in children with sickle cell anaemia. | sickle cell anaemia (sca) predisposes a child to infections for various reasons, including increased bone marrow turnover, poor perfusion and functional asplenia leading to decreased opsonisation of polysaccharide encapsulated organisms. bacteria and viruses that most frequently cause serious infections in children with sickle cell disease are streptococcus pneumoniae, haemophilus influenzae type b, salmonella spp., escherichia coli, staphylococcus aureus, mycoplasma pneumoniae, chlamydia pneumo ... | 2001 | 11735665 |
| bronchial chlamydia pneumoniae infection, markers of allergic inflammation and lung function in children. | a relationship between respiratory chlamydia pneumoniae infection (rcpi) and bronchial asthma is under discussion. our objective was to study the frequency of rcpi and whether it is associated with markers of asthma in children with recurrent or chronic bronchitis as well as pneumonia. one-hundred and forty-eight children who underwent bronchoscopy were enrolled; 42 children with additional respiratory infections were excluded. therefore, 106 children were examined, regarding a rcpi, by polymera ... | 2001 | 11737672 |
| c-reactive protein levels and viable chlamydia pneumoniae in carotid artery atherosclerosis. | an elevated serum level of c-reactive protein, an inflammatory marker, is an independent predictor of stroke and coronary artery disease. to determine whether chronic infection with chlamydia pneumoniae, which has been identified in atherosclerotic plaques, is responsible for systemic inflammation, we studied the association between serum c-reactive protein levels and infection of carotid artery atherosclerotic plaque with viable c pneumoniae. | 2001 | 11739967 |
| potential infectious etiologies of atherosclerosis: a multifactorial perspective. | coronary heart disease (chd) contributes substantially to illness and death worldwide. experimental studies demonstrate that infection can stimulate atherogenic processes. this review presents a spectrum of data regarding the link between chd and infection. in addition, the need for improved diagnostic tools, the significance of multiple pathogens, and potential intervention strategies are discussed. | 2001 | 11747688 |
| chlamydia pneumoniae secretion of a protease-like activity factor for degrading host cell transcription factors required for [correction of factors is required for] major histocompatibility complex antigen expression. | chlamydia pneumoniae is a causative agent for many respiratory infections and has been associated with cardiovascular diseases in humans. the pathogenicity of c. pneumoniae is thought to depend on its ability to cause persistent infection and to evade host defense. genome sequence analysis indicates that c. pneumoniae encodes a homologue of a chlamydial protease-like activity factor from c. trachomatis (cpafct). we designated the c. pneumoniae homologue as cpafcp. recombinant cpafcp was produced ... | 2002 | 11748200 |
| genomic approach for analysis of surface proteins in chlamydia pneumoniae. | chlamydia pneumoniae, a human pathogen causing respiratory infections and probably contributing to the development of atherosclerosis and heart disease, is an obligate intracellular parasite which for replication needs to productively interact with and enter human cells. because of the intrinsic difficulty in working with c. pneumoniae and in the absence of reliable tools for its genetic manipulation, the molecular definition of the chlamydial cell surface is still limited, thus leaving the mech ... | 2002 | 11748203 |
| interferon-beta induction by chlamydia pneumoniae in human smooth muscle cells. | clinical studies have suggested a causal or contributory role of chlamydia pneumoniae infection in asthma and atherosclerosis. the activation of synthetic functions of smooth muscle cells (smc) including the production of cytokines and growth factors plays a major role in the formation of fibrous atherosclerotic plaques as well as in structural remodelling of the airway wall in chronic asthma. in this study we demonstrated that c. pneumoniae induced the production of low levels of interferon (if ... | 2001 | 11750216 |
| viruses and multiple sclerosis. | 2001 | 11754680 | |
| inflammatory mechanisms. | traditional concepts of the pathogenesis of acute coronary syndromes have changed over the last few years. in particular it has been demonstrated that high-risk lesions are not necessarily angiographically severe. rather, unstable high risk lesions are the ones composed of large lipid cores and thin fibrous caps. it is now widely accepted that plaque instability is related to the development of inflammation within the intima. a consequence of this is that stabilization of lesions provides a new ... | 2001 | 11756204 |
| chlamydia pneumoniae infection in acute exacerbations of chronic obstructive pulmonary disease: analysis of 250 hospitalizations. | two hundred fifty hospitalizations were included in a serologically based prospective study to assess the role of chlamydia pneumoniae in episodes of acute exacerbation of chronic obstructive pulmonary disease (aecopd) and the percentage of copd patients chronically infected with this pathogen. chlamydia pneumoniae-specific igg, iga and igm antibody titers were determined using a commercial kit with the microimmunofluorescence method. a significantly higher geometric mean titer in the copd patie ... | 2001 | 11757970 |
| chlamydia pneumoniae infection and accelerated development of coronary artery disease in patients with chronic renal failure. | this study examined the relationship between chlamydia pneumoniae (c. pneumoniae) infection and the accelerated development of coronary artery disease (cad) in patients with chronic renal failure (crf). | 2001 | 11758004 |
| [prevalence of chlamydia pneumoniae antibodies in patients with coronary heart disease]. | a possible role of infectious agents in the pathogenesis and progression of cardiovascular system diseases has been postulated by many scientists. the purpose of our study was to evaluate the correlation between chlamydia pneumoniae infections and coronary heart disease. a group of 211 patients including: 120 patients with coronary heart disease (chd) [63 patients enrolled for precutaneous coronary interventions (ptca), 14 with proven restenosis after ptca and 43 after coronary artery bypass gra ... | 2001 | 11761832 |
| [chlamydia pneumoniae: an cause of reactive arthritis?]. | chlamydia pneumoniae is a common cause of acute infections within the upper respiratory tract. it is less well known that chlamydia pneumoniae, just like chlamydia trachomatis, may also trigger reactive arthritis. we describe three patients with arthritis possibly triggered by chlamydia pneumoniae. the patients showed the typical symptoms of reactive arthritis like asymmetric oligo- or polyarthritis, dactylitis, enthesiopathies and tendovaginitis. the course of the disease was quite different. t ... | 2001 | 11763621 |
| biology and clinical significance of chlamydiae. | 2001 | 11764738 | |
| [establishment and experimental study on mouse model of chlamydia pneumoniae pneumonitis]. | to evaluate mice as experimental animals for chlamydia pneumoniae (c. pneumoniae) infection and investigate the pathogenesis of c. pneumoniae pneumonitis. | 2001 | 11770419 |
| [the relationship between chlamydia pneumoniae and atherosclerosis]. | background: risk factors for arthrosclerosis have been well identified. more than ten years ago, an infectious process was incriminated, particularly the pathogenic effect of chlamydia pneumoniae in the development of atheromatous lesions responsible for ischemic cardiovascular diseases. data bases: several approaches have been used to assess the presence of a relationship between c. pneumoniae and the development of cardiovascular disease. serological, histopathological (study of the atheromato ... | 2001 | 11771205 |
| impact of infectious burden on extent and long-term prognosis of atherosclerosis. | recent findings suggest a causative role of infections in the pathogenesis of atherosclerosis. in hypothesizing an association between infectious agents and the development of atherosclerosis, we would expect a correlation to the extent of atherosclerosis. moreover, this effect could be multiplied by the number of pathogens to which an individual had been exposed. | 2002 | 11772870 |
| detection of chlamydia pneumonia dna in nasopharyngolaryngeal swab samples from patients with rhinitis and pharyngolaryngitis with polymerase chain reaction. | to assess the prevalence of chlamydia pneumomia dna in patients with otolaryngic disease. | 2000 | 11775549 |
| [study on combined detection of m. genitalium, m. pneumoniae and c. pneumonia by nested polymerase chain reaction in respiratory tract infections in pediatric patients]. | to study the respiratory tract infections by mg, m. genitalium (mpn), cpn, and co-infections by these agents in pediatric patients. | 1999 | 11775915 |
| [implication and mode of action of infectious agents in the formation of atheromatous plaques. infection and atherosclerosis]. | different kinds of infectious agents seem to be implied in the atherosclerotic process. indeed, some bacteria and viruses have been identified in atherosclerotic lesions: chlamydia pneumoniae, helicobacter pylori, streptococcus sanguis, porphyromonas gingivalis, herpes simplex viruses type 1 and 2, coxsakievirus b and hepatitis virus a. by their ability to induce antigenic and functional changes in the cells of the vascular wall (endothelial cells, smooth muscle cells, monocytes/macrophages, and ... | 2001 | 11776694 |
| antibodies to 60-kilodalton heat shock protein and outer membrane protein 2 of chlamydia pneumoniae in patients with coronary heart disease. | evidence linking chlamydia pneumoniae infection to atherosclerosis and to atherothrombotic events has recently emerged. a primary candidate implicated in these pathogenetic events is the 60-kda chlamydial heat shock protein (hsp60). another putative candidate to activate a potential proinflammatory mechanism is the chlamydial outer membrane protein 2 (omp2). we have generated both hsp60 and omp2 recombinant antigens in a nondenatured form and shown that (i) the two antigens were highly immunogen ... | 2002 | 11777831 |
| relation of antibiotic use to risk of myocardial infarction in the general population. | there are conflicting reports of an association between chlamydia pneumoniae (c. pneumoniae) infection and coronary artery disease (cad); randomized trials of antibiotics for the secondary prevention of cad are currently underway. physicians may be tempted to believe that their choice of antibiotic class in treating any infection may alter the risk of cad. our objective was to determine if the use of antibiotics with antichlamydial activity in the general population reduces the risk of myocardia ... | 2002 | 11779516 |
| effect of fenofibrate on chlamydia pneumoniae antibody levels in patients with coronary artery disease. | 2002 | 11779542 | |
| chlamydia pneumoniae and atherosclerosis: critical assessment of diagnostic methods and relevance to treatment studies. | a number of studies have found that inflammation of the vessel wall plays an essential role in both the initiation and progression of atherosclerosis and erosion and fissure and the eventual rupture of plaques. chlamydia pneumoniae is one of the infectious agents that have been investigated as possible causes of this inflammation. initial studies of the association of c. pneumoniae and cardiovascular disease (cvd) were seroepidemiologic, and these were followed by studies in which the organism w ... | 2002 | 11781264 |
| mannose-receptor positive and negative mouse macrophages differ in their susceptibility to infection by chlamydia species. | it has been shown that n-linked high mannose type oligosaccharides competitively inhibits attachment to and infectivity of chlamydiae in hela cells. to further study whether mannose moieties are involved in the infectivity of chlamydiae, the susceptibility of mannose-receptor negative j774a and positive j774e mouse macrophages to chlamydia trachomatis, chlamydia psittaci and chlamydia pneumoniae was evaluated. c. trachomatis infected mannose-receptor positive cells better than mannose-receptor n ... | 2002 | 11782120 |
| macrolide treatment after coronary stent placement. | 2001 | 11784661 | |
| antibodies anti-chlamydia pneumoniae and anti-mycoplasma pneumoniae in patients with negative serology for hantavirus. retrospective study. | the seroprevalence of chlamydia pneumoniae and mycoplasma pneumoniae in hantavirus seronegative patients, who had symptoms and signs compatible with pneumonia was established. for this purpose we used the indirect fluorescent antibody test. titers > or = 1:16 for c. pneumoniae and m. pneumoniae were found in 8.6% and 17.1% of the serum, respectively, showing evidence of recent or current infection. | 2001 | 11784935 |
| chlamydia trachomatis and mycobacterium tuberculosis lung infection in an hiv-positive homosexual man. | a 31-year-old homosexual man, who was human immunodeficiency virus (hiv)-positive was admitted for fever and cough. chest computed tomography (ct) revealed the presence of diffuse interstitial reticular nodulation, and brain nuclear magnetic resonance imaging showed the presence of nodular frontal lesions. microscopic examination of sputum and other body fluids showed the presence of acid-fast bacilli and culture-only growth mycobacterium tuberculosis. serology for respiratory tract pathogens wa ... | 2001 | 11788074 |
| constant relative rate of protein evolution and detection of functional diversification among bacterial, archaeal and eukaryotic proteins. | detection of changes in a protein's evolutionary rate may reveal cases of change in that protein's function. we developed and implemented a simple relative rates test in an attempt to assess the rate constancy of protein evolution and to detect cases of functional diversification between orthologous proteins. the test was performed on clusters of orthologous protein sequences from complete bacterial genomes (chlamydia trachomatis, c. muridarum and chlamydophila pneumoniae), complete archaeal gen ... | 2001 | 11790256 |
| chronic infections and atherosclerosis. | the inability of traditional risk factors such as hypercholesterolemia, hypertension, and smoking to explain the incidence of atherosclerosis (at) in about 50% of the cases prompted a search for additional putative risk factors involved in the development of the disease. infectious agents have long been suspected to initiate/contribute to the process of at. it has also been suggested that inflammation, either related to infectious agents or independent from infection, may mediate the atherogenic ... | 2001 | 11791347 |
| the emerging role of atypical pathogens in community-acquired pneumonia. | community-acquired pneumonia (cap) constitutes a major cause of morbidity and mortality. although streptococcus pneumoniae remains the bacterium most commonly implicated in cap, the atypical respiratory pathogens mycoplasma pneumoniae, legionella species, and chlamydia pneumoniae are being isolated with increasing frequency contrary to previous beliefs, these agents are capable of causing severe as well as mild-to-moderate illness. moreover, they can affect all age groups. indeed, atypical patho ... | 2002 | 11791627 |
| role of infection in alzheimer's disease. | alzheimer's disease (ad) is a chronic condition in which inflammation has been shown to contribute to neurodegeneration. current thinking suggests that deposition of beta-amyloid in the brain promotes inflammation resulting in neuronal damage/death. alternatively, our data suggest that chronic inflammation observed in late-onset sporadic ad may be stimulated by infection with the obligate, intracellular bacterium, chlamydia pneumoniae. our results indicate that c. pneumoniae is found in high fre ... | 2001 | 11794745 |
| chlamydia pneumoniae in the cerebrospinal fluid of patients with multiple sclerosis and neurological controls. | chlamydia pneumoniae infection is a common event in neurological patients and recovery of c. pneumoniae dna in the cerebrospinal fluids (csf) of multiple sclerosis (ms) patients could represent an epiphenomenon. we assessed the relevance of c. pneumoniae infection in 62 csf samples from 32 ms patients and 30 neurological controls by means of pcr, immunofluorescence microscopy, enzyme-linked fluorescence and antibody detection. multiple sclerosis (9.3%) and neurological controls (13.3) had simila ... | 2001 | 11795458 |
| effect of prolonged treatment with azithromycin, clarithromycin, or levofloxacin on chlamydia pneumoniae in a continuous-infection model. | persistent infections with chlamydia pneumoniae have been implicated in the development of chronic diseases, such as atherosclerosis and asthma. although azithromycin, clarithromycin, and levofloxacin are frequently used for the treatment of respiratory c. pneumoniae infections, little is known about the dose and duration of therapy needed to treat a putative chronic c. pneumoniae infection. in this study, we investigated the effect of prolonged treatment with azithromycin, clarithromycin, or le ... | 2002 | 11796350 |
| in vitro activities of bms-284756 against chlamydia trachomatis and recent clinical isolates of chlamydia pneumoniae. | the in vitro activities of bms-284756 (a novel des-fluoroquinolone), levofloxacin, moxifloxacin, and clarithromycin were tested against 5 strains of chlamydia trachomatis and 20 isolates of chlamydia pneumoniae. the mic at which 90% of the isolates were inhibited and the minimal bactericidal concentration at which 90% of the isolates were killed by bms-284756 for all isolates of c. pneumoniae and c. trachomatis was 0.015 microg/ml (range, 0.015 to 0.03 microg/ml). bms-284756 was the most active ... | 2002 | 11796366 |
| chlamydial heat shock protein 60 activates macrophages and endothelial cells through toll-like receptor 4 and md2 in a myd88-dependent pathway. | active inflammation and nf-kappab activation contribute fundamentally to atherogenesis and plaque disruption. accumulating evidence has implicated specific infectious agents including chlamydia pneumoniae in the progression of atherogenesis. chlamydial heat shock protein 60 (chsp60) has been implicated in the induction of deleterious immune responses in human chlamydial infections and has been found to colocalize with infiltrating macrophages in atheroma lesions. chsp60 might stimulate, enhance, ... | 2002 | 11801686 |
| [genome analysis of pathogenic bacteria]. | 2001 | 11802401 | |
| [chlamydia pneumoniae infection in patients with chronic obstructive pulmonary disease]. | to investigate the association of chlamydia pneumoniae infection with chronic obstructive pulmonary disease (copd). | 2001 | 11802964 |
| effect of chlamydia pneumoniae infection on coronary flow reserve and intimal hyperplasia after stent implantation in patients with angina pectoris. | chlamydia pneumoniae (c. pneumoniae) has been detected in tissue from coronary atherosclerotic vascular lesions and may be involved in the pathogenesis of atherosclerosis. however, the effect of prior c. pneumoniae infection on coronary intimal hyperplasia after stent implantation and on coronary microvascular function is unknown. | 2001 | 11806088 |
| [clinical significance of interaction between chlamydia infection (chlamydia pneumoniae) and free radical processes during ischemic heart disease]. | to determine occurrence and activity of chlamydial infection (ci) as well as activity of free radical processes in clinical course of different forms of ischemic heart disease. | 2001 | 11806203 |
| analysis of the serological response to chlamydia pneumoniae in patients with ischemic heart disease by recombinant momp-elisa. | to investigate the humoral immune response to the major outer membrane protein (momp) of chlamydia pneumoniae, a fusion protein, thioredoxin-(his)6-momp (rmomp) was produced in escherichia coli and purified; this served as an antigen to establish an enzyme-linked immunosorbent assay (elisa). specific igg and iga antibodies against rmomp were determined in sera from patients with ischemic heart disease. the findings were compared with those obtained by elisa using the outer membrane protein compl ... | 2001 | 11810581 |
| seroepidemiology in chlamydia pneumoniae-- atherosclerosis association. | 2002 | 11812058 | |
| serological markers of chlamydia pneumoniae infection in men and women and subsequent coronary events; the scottish heart health study cohort. | to investigate the relationship between serum markers of chlamydia pneumoniae infection and subsequent coronary events. methods and | 2002 | 11812066 |
| chlamydia pneumoniae and atherosclerosis. | based on seroepidemiological studies, chlamydia pneumoniae has been suspected to play a role in atherosclerosis. the organism was searched for in atherosclerotic lesions by electron microscopy, immunohistochemistry, culture and pcr. it appears from published data and our own investigations that contrary to what could be expected, the sensitivity of pcr is much lower than that of the 3 other techniques. moreover, pcr results are frequently conflicting. we therefore propose to interpret the result ... | 2001 | 11813502 |
| chlamydia pneumoniae infection and atherosclerosis: methodological considerations. | 2002 | 11815446 | |
| [new infectious diseases]. | 2001 | 11820173 | |
| [chlamydia pneumoniae--chronic infection and atherosclerosis]. | recent evidence suggests that common chronic infections may contribute to the initiation and/or progression of atherosclerosis. infection of the vascular wall with chlamydia pneumoniae, a gramnegative bacterium, has been linked with coronary heart disease, myocardial infarction and stroke in epidemiological studies and in pathological studies using immunohistochemistry and electron microscopy. in addition striking evidence for an active role of chlamydia pneumoniae in atherogenesis has been prov ... | 2001 | 11820175 |
| [infection hypothesis of coronary heart disease]. | it is well accepted that coronary artery disease is linked to an inflammatory process. it is unproven however whether either infectious agents may cause or accelerate coronary artery disease or the inflammatory process is due to metabolic or toxic effects. among the possible infectious agents chlamydia pneumoniae is the most likely bacterium involved in atherosclerosis. the arguments in favour of chlamydia pneumoniae originate from seroepidemiologic studies and from detection and isolation of ba ... | 2001 | 11820176 |
| risk factors of wheeze and allergy after lower respiratory tract infections during early childhood. | lower respiratory tract infections (lris) during early childhood can lead to bronchial hyperreactivity or recurrent obstructive bronchitis. the role of lris in the pathogenesis of allergic diseases such as allergic rhinoconjunctivitis, atopic eczema, and bronchial asthma is less clear. the aim of this retrospective study was to determine the incidence of subsequent wheezing and atopy, and the known risk factors for allergic sensitization in 74 children hospitalized for acute lris of various etio ... | 2001 | 11825005 |
| development and evaluation of real-time pcr-based fluorescence assays for detection of chlamydia pneumoniae. | chlamydia pneumoniae is an important respiratory pathogen recently associated with atherosclerosis and several other chronic diseases. detection of c. pneumoniae is inconsistent, and standardized pcr assays are needed. two real-time pcr assays specific for c. pneumoniae were developed by using the fluorescent dye-labeled taqman probe-based system. oligonucleotide primers and probes were designed to target two variable domains of the ompa gene, vd2 and vd4. the limit of detection for each of the ... | 2002 | 11825973 |
| evaluation of chlamydia pneumoniae and mycoplasma pneumoniae as etiologic agents of persistent cough in adolescents and adults. | chlamydia pneumoniae and mycoplasma pneumoniae were evaluated as agents of persistent cough in adolescents and adults (n = 491). tests of 473 respiratory specimens by culture or pcr or both identified four episodes (0.8%) of m. pneumoniae-associated illness and no episodes of c. pneumoniae illness, suggesting that these bacteria do not frequently cause persistent cough. | 2002 | 11825984 |
| culture-negative endocarditis due to chlamydia pneumoniae. | we report on the case of a 54-year-old woman diagnosed as having culture-negative endocarditis (clinical and histopathologic evidence compatible with a recent episode of endocarditis). the responsibility of chlamydia pneumoniae in this episode of endocarditis was suggested by a serological study and was then confirmed by the positive results of pcr and in situ hybridization tests with aortic and mitral valves tissues. to our knowledge, this is the first case of endocarditis due to c. pneumoniae ... | 2002 | 11826006 |
| [chlamydia pneumoniae and myocardial infarct? (serologic study)]. | at disposal for tests were 156 blood sera collected from patients with acute myocardial infarction (ami samples) and 67 blood sera collected from control persons. the sera were tested by the following reactions: complement fixation test (cft) with genus-specific antigen (c. psittaci, bioveta, ivanovice na hané), elisa in the immunoglobulin classes igg and iga using the momp (vircell, spain) and lps (medac, hamburg, brd) chlamydia pneumoniae (c. p.) antigens, and indirect immunofluorescence test ... | 2001 | 11826549 |
| detection of chlamydophila pneumoniae dna in peripheral blood mononuclear cells of blood donors in the north-east of italy. | recent studies have implicated chlamydia pneumoniae (now chlamydophila pneumoniae) in the pathogenesis of atherosclerosis and demonstrated its presence within human peripheral blood mononuclear cells (pbmcs). in this study the presence of c. pneumoniae dna was assessed, using nested pcr, in pbmcs from 169 active blood donors as a function of age, of specific antibodies and c-reactive protein. the results obtained demonstrated a high degree of global positivity (46.15%), which was higher in femal ... | 2001 | 11827203 |
| [chlamydiaceae and cancer]. | 1999 | 11830871 | |
| high sensitivity immunoassays for c-reactive protein: promises and pitfalls. | c-reactive protein (crp) has historically been measured in the clinical laboratory for the detection and monitoring of occult infection and inflammation, using immunoturbidimetric or immunonephelometric techniques. the recent commercial availability of automated high-sensitivity assays has enabled investigators to measure crp at levels previously unattainable on a routine basis and to explore its clinical utility in apparently healthy individuals. crp concentrations increased above the individua ... | 2001 | 11831635 |
| antibiotics against chlamydia pneumoniae and prognosis after acute myocardial infarction. | there is mounting pathologic and immunologic evidence that chlamydia pneumoniae plays a role in the atherogenic pathway. however, very few clinical studies have supported these findings. | 2002 | 11835034 |
| recurrent pneumonia due to persistent chlamydia pneumoniae infection. | two cases of recurrent pneumonia due to chlamydia pneumoniae are described. c. pneumoniae was continuously detected from the nasopharynx in both patients by the polymerase chain reaction and/or culture even with appropriate antibiotic therapy during the first episode. after eradication of c. pneumoniae with long-term macrolide therapy, the respiratory symptoms of both patients completely disappeared and no relapse was observed. these data indicate that new treatment strategies may be necessary t ... | 2002 | 11838587 |
| elevated interleukin-6 predicts progressive carotid artery atherosclerosis in dialysis patients: association with chlamydia pneumoniae seropositivity. | the cardiovascular mortality rate is unacceptably high in patients with end-stage renal disease (esrd), which suggests an accelerated atherogenic process. the cause(s) of the accelerated atherogenesis in esrd patients are not known, though recent studies suggest that persistent infection, such as chlamydia pneumoniae, and proinflammatory cytokines may contribute. forty-five esrd patients (26 men) aged 51 +/- 2 years was studied at a time-point close to start of dialysis treatment and again after ... | 2002 | 11840367 |
| association analysis of polymorphisms at the interleukin-1 locus in essential hypertension. | infection with microorganisms such as helicobacter pylori and chlamydia pneumoniae has been associated with coronary heart disease (cad) and hypertension (ht). infection increases the release of pro-inflammatory cytokines, thus facilitating interactions that lead to vascular damage and other effects. we hypothesized that genetically determined differences in activity or responsiveness of cytokine(s) might contribute to ht. the interleukin-1 gene (il1) cluster on chromosome 2q14 contains three re ... | 2002 | 11840488 |
| detection of chlamydia pneumoniae in unexplained pulmonary hypertension. | the pathogenesis of primary pulmonary hypertension is still unclear. the case of a 68-yr-old female patient who complained of recurrent dizzy spells and collapses over a period of 6 weeks and died of global cardiac failure is presented. autopsy revealed severe pulmonary hypertension, slight chronic bronchitis, and bronchiolitis as well as intra-alveolar accumulation of macrophages. chlamydiae were detected within the pulmonary arteries and in intramural and intra-alveolar macrophages by immunofl ... | 2002 | 11843318 |
| chlamydia pneumoniae iga titres and coronary heart disease; prospective study and meta-analysis. | to examine associations between chlamydia pneumoniae iga titres and incident coronary heart disease, and to compare them with associations previously reported between c. pneumoniae igg titres and coronary heart disease. | 2002 | 11846494 |
| association between interleukin-6 and carotid atherosclerosis in hemodialysis patients. | interleukin-6 (il-6) is associated with cardiovascular complications in general subjects. although blood il-6 is greatly elevated in hemodialysis (hd) patients, the role of il-6 in the advance of atherosclerosis remains to be determined. | 2002 | 11849469 |
| parameters of inflammation and infection in a community based case-control study of coronary heart disease. | increased levels of systemic inflammatory markers appear to be related to coronary heart disease (chd) both in asymptomatic individuals and in subjects with established chd. whether these associations are related to confounding coronary risk factors or are explicable through chronic infectious conditions is not clear. | 2002 | 11849671 |
| discriminative value of serum amyloid a and other acute-phase proteins for coronary heart disease. | we studied the value of serum amyloid a (saa), a first-class acute-phase protein, as a marker for coronary heart disease (chd) in a middle-aged male population. in a working population of 16307 men (age, 35-59 years), 446 cases had a history of chd or prominent q:qs waves on electrocardiogram. for each case, two matched controls were investigated. saa, measured by immunonephelometry, was correlated with other acute-phase proteins, cardiovascular risk factors, and infectious serology markers. saa ... | 2002 | 11849673 |
| interleukin-1 receptor antagonist is detectable in human carotid artery plaques and is related to triglyceride levels and chlamydia pneumoniae iga antibodies. | to investigate whether the interleukin-1 receptor antagonist (il-1ra) and interleukin-1beta (il-1beta) can be detected in human carotid artery tissue, and whether their presence is related to evidence of chlamydia pneumoniae infection, risk factors for atherosclerosis, and clinical data. | 2002 | 11851866 |
| chlamydia pneumoniae and cardiovascular disease. | chlamydia pneumoniae, a respiratory pathogen, has been suggested as a risk factor for cardiovascular disease. epidemiologic data are very controversial. histopathologic and microbiologic studies have established an association between atherosclerosis and presence of c. pneumoniae, consistently finding c. pneumoniae dna and antigens in atherosclerotic arteries. c. pneumoniae has been cultured from atherosclerotic arteries in several centers. an etiologic role for c. pneumoniae in initiation, acce ... | 2002 | 11853655 |
| detection and typing of respiratory adenoviruses in a single-tube multiplex polymerase chain reaction. | a multiplex polymerase chain reaction (pcr) assay that is capable of detecting and typing six serotypes of respiratory adenovirus (ad) was developed, using multiple sets of type-specific primers. the detection of each different serotype depended on distinguishing different numbers and sizes of amplification products on agarose gels following pcr. the multiplex pcr was tested with 26 clinical ad isolates and other respiratory viruses including influenza viruses, parainfluenza viruses, and respira ... | 2002 | 11857530 |
| chlamydia pneumoniae as a respiratory pathogen. | chlamydia pneumoniae is a recently recognized human respiratory pathogen with a unique biphasic life cycle characterized by an obligate intracellular (replicative) and an extracellular (infectious) form of the organism. c. pneumoniae is widely distributed and, via the respiratory route, infects the majority of the world's population. the majority (70%) of acute human c. pneumoniae respiratory tract infections are asymptomatic or only mildly symptomatic but a minority (30%) cause more severe resp ... | 2002 | 11861211 |
| non-specific interstitial pneumonia and chlamydia pneumoniae infection. | recently, the clinical features of non-specific interstitial pneumonia (nsip) have been described. we hypothesize that recurrent infection caused by chlamydia pneumoniae may play a role in the pathogenesis of nsip. to prove this, we quantified serum iga and igg antibodies against c. pneumoniae using the enzyme linked-immunosorbent assay kit. the study included 15 patients diagnosed with nsip, 20 patients with chronic obstructive pulmonary diseases (copd) as disease group, and 27 control subjects ... | 2001 | 11862004 |
| microbial etiology of acute community-acquired pneumonia in adult hospitalized patients in yaounde-cameroon. | objective: to determine the microbial etiology of acute community-acquired pneumonia in yaoundé. methods: ninety-one consecutive adult patients admitted to hospital for radiologically confirmed acute community-acquired pneumonia were studied prospectively. sputum microscopy and culture, blood cultures, pneumococcal antigen detection in serum and serologic analysis for agents of atypical pneumonia and for human immunodeficiency virus (hiv) were performed for most patients. results: there were 65 ... | 1997 | 11864102 |
| chlamydia pneumoniae: a new opportunistic infectious agent in aids? | objective: to determine the incidence of chlamydia pneumoniae respiratory tract infection in hiv-positive or aids patients. methods: serum samples from 82 hiv-positive patients with fever and respiratory symptoms were evaluated using microimmunofluorescence assay to detect c. pneumoniae-specific igg and igm antibodies. results: twenty patients were found to have igg antibodies to c. pneumoniae at titers ranging between 1:16 and 1:1024. seven of the patients had evidence of acute c. pneumoniae in ... | 1997 | 11864103 |
| atypical respiratory pathogens. | the main atypical pathogens in respiratory tract infections are classified on the basis of their ability to cause atypical pneumonia. this is not a well-defined clinical entity, and it is evident that atypical pathogens can sometimes cause 'typical' pneumonias and vice versa. this emphasizes the need for microbiological diagnosis, since it affects the selection of proper treatment, in which beta-lactam antibiotics and aminoglycosides are not effective. moreover, mixed infections caused by atypic ... | 1997 | 11864199 |
| typing strains of chlamydia pneumoniae by amplified fragment length polymorphism typing. | 1998 | 11864268 | |
| unraveling the host immune response to vacuolar pathogens. | 2002 | 11864817 |