Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| radiation-induced dna damage in tumors and normal tissues. i. feasibility of estimating the hypoxic fraction. | it is well known that the type and quantity of dna damage produced by ionizing radiation depend on the oxygen concentration around the dna. for example, in irradiated mammalian cells, both a decrease in the dna strand break efficiency and the induction of dna-protein crosslinks (dpcs) occur as the extracellular oxygen concentration is decreased below 1%. in the study reported here, the feasibility of estimating the hypoxic fraction of irradiated tumors and normal tissues was investigated by meas ... | 1993 | 8210342 |
| [changes in the hemogram and in the laboratory parameters indicative of iron metabolism in mild viral infections]. | to assess the duration and intensity of the changes appearing in laboratory values related to iron utilisation during viral infection. | 1993 | 8211547 |
| late cyclosporine treatment ameliorates established coronary graft disease in rat allografts. | the development of post-transplantation coronary graft disease (cgd) is a major cause of late morbidity and mortality. recent reports have suggested that cgd is a type of chronic vascular rejection, possibly enhanced by cofactors such as concurrent cmv infection and hyperlipidemia. it remains controversial whether established cgd can be improved by modifications in immunosuppressive therapy. the purpose of this study was to examine whether csa could reverse or halt the progression of cgd after i ... | 1993 | 8212146 |
| the use of intravenous immunoglobulin in miller fisher syndrome. | we report a patient with miller fisher syndrome who was treated with an intravenous high-dose of immunoglobulin. this syndrome is considered to be a benign variety of acute inflammatory demyelinating polyneuropathy (guillain-barré syndrome). however, there have been several reports of the need for ventilatory support and a few cases have had a fatal outcome. we observed a case of progressive miller fisher syndrome in a 3-year-old boy. following 2 episodes of apnea lasting about 50 s each, he was ... | 2004 | 8214351 |
| the in vivo effect of tachykinins on airway mast cells of the rat. | the tachykinins substance p (sp) and neurokinin a (nka) have been demonstrated in sensory airway nerves of animals and man and are thought to be neurotransmitters of local axon reflexes, generated by stimuli such as cigarette smoke, dust, histamine, and bradykinin. we previously showed that intravenous sp and nka caused bronchoconstriction in anesthetized, mechanically ventilated rats. pharmacologic studies suggested that this occurred by an indirect mechanism, probably mediated by acetylcholine ... | 1993 | 8214946 |
| mitral valve carpentier-edwards bioprosthetic replacement, thromboembolism, and anticoagulants. | patients undergoing mitral valve replacement (mvr) using a bioprosthesis are frequently placed on long-term anticoagulant treatment, and thereby lose the main advantage conferred by the bioprosthesis. to assess predictive factors of the need for long-term anticoagulant treatment, 100 consecutive patients surviving bioprosthetic mvr between 1977 and 1987 were followed up. the estimated thromboembolism-free survival was 88.9% +/- 3.6% after 6 years of follow-up. preoperative risk factors for throm ... | 1993 | 8215671 |
| radiosurgery for acoustic neuroma. | radiosurgery has been used for many years with great success for the treatment of acoustic neuroma. we present three cases in louisiana using the e l fisher system, the results of treatment, and a discussion of acoustic neuroma. | 1993 | 8228537 |
| diagnostic significance of antibodies to hepatitis b virus polymerase in acutely and chronically hbv-infected individuals. | the prevalence and time course of the occurrence of antibodies to the hepatitis b virus polymerase (anti-hbpol) were investigated in acutely and in chronically hbv-infected individuals by using recombinant hbpol protein for western blot analysis. one group consisted of 19 patients who were acutely infected and recovered completely. five of these patients (26%, 69 serum samples examined) exhibited anti-hbpol. among those anti-hbpol positive patients, recovery from the disease was combined with a ... | 1993 | 8228919 |
| [prospective study of cataract after 5 years intraocular lenses with and without laser ridge]. | a prospective randomized study was carried out to investigate whether intraocular lenses with and without laser ridge have different effects on the development of secondary cataract. | 1993 | 8231041 |
| amygdala kindling rate is altered in rats with a deficit in the responsiveness of the hypothalamo-pituitary-adrenal axis. | fisher and lewis rats were amygdala kindled in the morning and in the evening. fisher rats displayed a diurnal variation in the rate of kindling through stage 2 which did not exist in the lewis rats. lewis rats also take much longer to kindle through stage 2 and a subcutaneous corticosterone pellet accelerates this rate. these observations are consistent with the hypothesis that the hormones of the hypothalamo-pituitary-adrenal (hpa) axis, particularly the glucocorticoids, play a role in epilept ... | 1993 | 8233039 |
| impairment of natural resistance to toxoplasma gondii infection in rats treated with beta adrenergics, beta blockers, corticosteroids or total body irradiation. | the data shows that fisher rats treated with propranolol, betamethasone or exposed to cobalt60-treatment before challenge with t. gondii exhibit an impaired resistance to this opportunistic parasite infection. in fact, in rats propranolol-treatment induces an increase mortality rate up to 66.6% (p < 0.01, with respect to controls). whereas betamethasone or cobalt60-treatment induces an increased of mortality rate about 33.3% (p < 0.05 respectively, with respect to unirradiated rats). in contrast ... | 1993 | 8233643 |
| the performance of two intensive care humidifiers at high gas flows. | high continuous flow breathing systems are now available to provide fresh gas flows well in excess of 100 l.min-1 in continuous positive airway pressure systems used for respiratory support. the performance of two commonly used intensive care humidifiers, the kendal conchatherm and the fisher and paykel fp310 have been assessed at flows of 50, 75, 100, 125 and 150 l.min-1. their performance when using two humidifiers connected in parallel and in series was also studied. at a fresh gas flow of 10 ... | 1993 | 8238837 |
| immune system of the spontaneously hypertensive rat: ii. morphology and function. | the spontaneously hypertensive rat (shr) is a stress-sensitive animal which exhibits moderate immune dysfunction that has been implicated in the onset of hypertension. in this study, we examined the morphology of shr thymus and spleen and further characterized the immune deficiency using wistar-kyoto (wky) and fisher 344 (f-344) rats for comparison. the adult shr thymus does not display the increase in medullary volume typically noted with aging and the volume density of the marginal zone is dec ... | 1993 | 8238975 |
| cholinergic and non-cholinergic synaptic mechanisms in the aged rat hippocampus. | we compared age-related alterations in the electrophysiological and pharmacological properties of ca1 hippocampal pyramidal neurons in three strains of rats (sprague-dawley, fisher 344 and wistar) at 3-4 and 25-32 months of age, using the in vitro slice preparation. the most consistent age-related alterations were: a decrease in membrane excitability, a decrease in the amplitude and duration of inhibitory postsynaptic potentials and a decreased sensitivity to the effect of the cholinergic agonis ... | 1993 | 8239289 |
| a placebo-controlled trial of intravenous and oral disopyramide for prevention of neurally mediated syncope induced by head-up tilt. | a double-blind randomized trial was designed to determine the efficacy of intravenous and oral disopyramide phosphate in preventing neurally mediated syncope induced by a head-up tilt test. | 1993 | 8245337 |
| speech and swallow function after tonsil/base of tongue resection with primary closure. | speech and swallowing function was examined in 11 patients who underwent surgical resection of greater than 1 cm of tongue base, tonsil, and faucial arch with mandible resected on the side of the tumor and reconstruction by primary closure. preoperatively and 1 and 3 months post-healing, high fidelity audio recordings were made of a 6- to 7-minute conversational speech sample, the sentence version of the fisher logemann test of articulation competence was administered, and videofluoroscopic asse ... | 1993 | 8246480 |
| stress alters adenylyl cyclase activity in the pituitary and frontal cortex of the rat. | we hypothesized that sustained biosynthesis of proopiomelanocortropin (pomc) from the anterior pituitary during chronic stress might result in enhanced membrane adenylyl cyclase (ac) activity, facilitating amplification of the crh signal despite falling numbers of crh receptors. therefore, we investigated the effects of stress on ac activity in anterior pituitaries from sprague-dawley rats exposed to stress. following 12 h of intermittent, cold, swim stress, stressed rats had plasma corticostero ... | 1993 | 8246667 |
| [1992 nobel prize of medicine and physiology: edwin krebs and edmond fisher. protein phosphorylation and a hot summer]. | 1993 | 8246736 | |
| morphologic alterations of choline acetyltransferase-positive neurons in the basal forebrain of aged behaviorally characterized fisher 344 rats. | we examined fisher 344 female rats aged 6, 27, and 33 months old. prior to sacrifice and morphometric analyses of forebrain cholinergic neurons all rats underwent behavioral characterization in a spatial learning task using the morris water maze. performance on the spatial task permitted subsequent grouping of the 27- and 33-month-old animals into impaired or nonimpaired groups. importantly, the percentage of animals that displayed spatial impairments increased sharply with advancing age. quanti ... | 1993 | 8247228 |
| the effect of endogenous cholecystokinin released by bombesin and trypsin inhibitor on the regeneration of the pancreas. | this study examined the effects of endogenous cholecystokinin (cck) released by bombesin and foy-305 (a synthetic inhibitor of trypsin on pancreatic regeneration in rats). | 1993 | 8257223 |
| venous thromboembolism and high grade gliomas. | a retrospective study was done to determine the incidence of and the risk factors predisposing to clinical venous thromboembolism (vte) in patients treated for high grade gliomas. medical records of 68 consecutive patients diagnosed and treated at saint francis hospital and medical center from january 1986 to june 1991 were reviewed. the follow up was to time of death or at least 6 months (up to december 1991). all clinically suspected episodes of vte were confirmed by objective tests. sixteen e ... | 1993 | 8259536 |
| variance components for statistical genetics: applications in medical research to characteristics related to human diseases and health. | ra fisher introduced variance components in 1918. he synthesized mendelian inheritance with darwin's theory of evolution by showing that the genetic variance of a continuous trait could be decomposed into additive and non-additive components. the model can be extended to include environmental factors, interactions, covariation, and non-random mating. identifiability depends critically on design. methods of analysis include modelling the mean squares from a fixed effects analysis of variance, and ... | 1993 | 8261258 |
| population relationships of lapps as reflected by quantitative dermatoglyphics. | relationships and divergence among five lapp samples were assessed using finger and palm interdigital ridge counts. lapp relationships to other uralic speakers were also assessed. multivariate minimum fst values expressing differentiation among lapps are 0.012. these values are higher than those for most european populations and show the importance of isolation and genetic drift in lapp populations. skolt lapps and lapps of the kola peninsula are generally more similar to each other and are diff ... | 1993 | 8262502 |
| estimating selective advantage of two alleles in discrete time. | a class of estimators for the selective advantage, s, in a wright-fisher model with two alleles, variable population size, and genic selection is derived via martingale theory. explicit expressions are given for these estimators which only involve simple computation. the optimal estimate among this class of estimators is obtained. asymptotic results are readily established by an application of a martingale central limit theorem. the performance of this optimal estimator is compared to known esti ... | 1993 | 8263425 |
| increased arginine vasopressin secretion may participate in the enhanced susceptibility of lewis rats to inflammatory disease. | lewis (lew/n) and fisher (f344/n) rats are histocompatible inbred strains characterized respectively by susceptibility and resistance to inflammatory disease. lew/n rats have deficient corticotropin-releasing hormone (crh), acth and corticosterone responses to inflammation, and increased circulating and hypothalamic concentrations of arginine vasopressin (avp). crh is produced locally at inflammatory sites, where it acts as a proinflammatory agent, while avp has been reported to exert immunopote ... | 1993 | 8264843 |
| an evaluation of autonomic nervous system function in patients with prader-willi syndrome. | prader-willi syndrome (pws) is a complex multisystem genetic disorder in which many cardinal features may have a neurologically based pathophysiology involving both the central and peripheral components of the autonomic nervous system. autonomic nervous system function was studied noninvasively in a group of subjects with pws and control subjects to determine whether autonomic nervous system dysfunction exists as part of the pws. | 1994 | 8265328 |
| using computer algebra to determine rate constants in biochemistry. | in earlier work we have described how computer algebra may be used to derive composite rate laws for complete systems of equations, using the mathematical technique of gröbner bases (bennett, davenport and sauro, 1988). such composite rate laws may then be fitted to experimental data to yield estimates of kinetic parameters. recently we have been investigating the practical application of this methodology to the estimation of kinetic parameters for the closed two enzyme system of aspartate amino ... | 1993 | 8266745 |
| effect of hemoglobin solution on the response of intracranial and subcutaneous 9l tumors to antitumor alkylating agents. | the 9l gliosarcoma growing subcutaneously in the hind leg of the fisher 344 rat contains major areas of severe (< 5 mmhg) hypoxia, making up about 49% of the tumor. intravenous administration of an ultrapurified polymerized bovine hemoglobin solution (8 ml/kg) along with normal air breathing reduces the percentage of severe hypoxia to about 24% and increases oxygenation throughout the tumor. coadministration of the hemoglobin solution increased the tumor growth delay of subcutaneously implanted ... | 1993 | 8269590 |
| [the p 300 potential in schizophrenia]. | the p3 component of the event-related potential (e.r.p.) is an endogenous positive wave with a latency of approximately 300 msec, which is typically elicited by rare target stimuli in a detection task. the p3 has been applied to the study of cognitive impairments. one of the most consistently replicated biologic observation in schizophrenia is the p3 amplitude reduction. more recently, a prolonged p 3 latency has been observed by some authors. nevertheless, when the heterogeneity of the schizoph ... | 2006 | 8275907 |
| [analgesic effects of a raw extract of ageratum conyzoïdes in the rat]. | ageratum conyzoïdes (ac) is a plant used in traditional medicine for mental and infection diseases, cephalgia, dyspnea, enteralgia and fever. the objective of this study is to investigate the antinoceptive properties of ageratum conyzoïdes in the rat. the raw extract of ac is constituted by a lyophilisated powder obtained from leaves juice extract by using a crusher. a dilution of 1% in nacl 0.9% is prepared with the lyophilisat. several doses of this preparation; 25, 50, 100, 125, 150 mg/kg are ... | 1993 | 8275920 |
| the effect of dexamethasone administration on rat intestinal permeability: the role of bacterial adherence. | previous studies have shown that dexamethasone administration to rats results in diminution of biliary secretory immunoglobulin a concentration and alters intestinal barrier function to bacteria. the aims of this study were to examine and characterize the effect of dexamethasone on intestinal permeability and to determine the possible influence of bacterial adherence to the mucosa in this process. | 1994 | 8276206 |
| patterns of failure following loco-regional radiotherapy in the treatment of limited stage small cell lung cancer. | the probability of treatment resistant cells developing in a tumor, such as small cell lung cancer (sclc) which has a rapid cell cycle time, is a function of the number of tumor cells present and of time. theoretically, the development of resistance to chemotherapy and radiotherapy should be minimized by using all treatment modalities early in the treatment program. | 1994 | 8276650 |
| new experimental model of proximal and distal colon transposition in rats. | the proximal and distal portions of the colon have different morphologic and histochemical features. to ascertain whether these features are genetically or environmentally determined, we attempted to develop a transposition model of the proximal and distal portions of the colon in rats. four-month-old male fisher 344 rats were used. four centimeters of the proximal colon segment circulated by the right colonic artery and 4 cm of the distal colon segment circulated by the middle colic artery were ... | 1993 | 8277725 |
| neurotoxicologic examination of rats exposed to 1,1,1-trichloroethane vapor for 13 weeks. | large evoked potential and eeg changes occurred in a pilot study in fisher 344 rats during exposure to 2000 ppm of 1,1,1-trichloroethane (1,1,1-t; a cleaning solvent with anesthetic properties). in the main study, rats were evaluated for persistent nervous system effects the week following exposure to 0, 200, 630, or 2000 ppm 1,1,1-t for 6 h/day, 5 days/week, for 13 weeks. rats were clinically examined regularly and were given a functional observational battery monthly (fob, including forelimb a ... | 1993 | 8277925 |
| strain-dependent effect of ethanol on ventricular septal defect frequency in white leghorn chick embryos. | we have tested the potential of a single dose of ethanol (0.20 ml 50% ethanol in chick ringer's saline (crs) administered into the air sac) to produce ventricular septal defect (vsd) in three distinct commercially available strains of white leghorn chick embryo: stress-resistant dekalb delta strain, hy-vac spf type v, and hy-vac spf type l. eggs were controlled for both size and developmental stage (hamburger-hamilton stage 18-19) at time of injection. the frequency of vsd in dekalb delta embryo ... | 1993 | 8278929 |
| stereotaxic target calculation. theory and practice. | modern neuro-imaging techniques have significantly increased the accuracy of stereotactic procedures and have thereby generated a renewed interest in guided brain surgery. this paper describes the neuroradiological aspects of stereotaxic target calculation (x-, y-, z- coordinates) using the riechert-mundinger (fisher) frame for computed tomography (ct). selected cases are shown, illustrating patient positioning, ct technique, target identification and calculation. the importance of obtaining pre ... | 1993 | 8279290 |
| the nitrogen-regulated bacillus subtilis nrgab operon encodes a membrane protein and a protein highly similar to the escherichia coli glnb-encoded pii protein. | expression of beta-galactosidase encoded by the nrg-29::tn917-lacz insertion increases 4,000-fold during nitrogen-limited growth (m.r. atkinson and s. h. fisher, j. bacteriol. 173:23-27, 1991). the chromosomal dna adjacent to the nrg-29::tn917-lacz insertion was cloned and sequenced. analysis of the resulting nucleotide sequence revealed that the tn917-lacz transposon was inserted into the first gene of a dicistronic operon, nrgab. the nrga gene encodes a 43-kda hydrophobic protein that is likel ... | 1994 | 8282685 |
| high-dose oxytocin: 20- versus 40-minute dosage interval. | to determine whether an increase in the oxytocin dosing interval would decrease the incidence of uterine hyperstimulation. | 1994 | 8290186 |
| peripheral adaptations in trained aged rats with femoral artery stenosis. | the development and functional significance of exercise-induced peripheral adaptations were evaluated in aged animals with peripheral arterial insufficiency. fisher 344 male rats (21 months old) were subjected to bilateral stenosis of the femoral arteries sufficient to limit active hyperemia but not to impair resting blood flow. beginning the third day after stenosis, animals were (1) exercised by walking (n = 12) on a treadmill at 20 m/min at 15% inclination, twice a day, 5 days per week, or (2 ... | 1994 | 8293562 |
| pinhole spect: an approach to in vivo high resolution spect imaging in small laboratory animals. | the performance of pinhole spect and the application of this technology to investigate the localization properties of radiopharmaceuticals in vivo in small laboratory animals are presented. | 1994 | 8295008 |
| [management for subarachnoid hemorrhage with negative initial angiography]. | subarachnoid hemorrhage (sah) is commonly caused by ruptured aneurysm or arteriovenous malformation which is detected by cerebral angiogram. however, since angiograms sometimes cannot show the origin of sah, we review 12 cases (6.3% of total sah) to assess the management of these cases. we divided the 12 cases into three groups. group a (occulted aneurysm group) consisted of six cases of which aneurysms were detected by repeated angiographies in four, and by surgical procedures in two. group u ( ... | 1994 | 8295701 |
| miller fisher syndrome, a brainstem encephalitis, mimics brain death. | miller fisher syndrome is a rare focal encephalitis of the brainstem characterized by cranial nerve palsy, ataxia, and areflexia. while this condition usually is mild and self-limiting, as this case documents, findings may fulfill many of the criteria in the clinical examination for brain death. unlike brain death, however, it is not associated with irreparable structural damage of the brain or, as is mandatory, does it fulfill a very important prerequisite of brain death, the exclusion of poten ... | 1993 | 8299301 |
| embryonic implantation in mice is blocked by interleukin-1 receptor antagonist. | we have investigated the relevance of interleukin-1 receptor type i (il-1r ti) in the implantation process in vivo in a murine model. indirect immunofluorescence experiments demonstrate that il-1r ti is located in mouse endometrial lumenal epithelium with increased intensity in the periimplantation period, whereas il-1 beta staining is located in the mouse placenta. pmsg/human cg (hcg)-stimulated and mated 12-week-old b6c3f-1 female mice were randomly allocated to three groups: a, control noninj ... | 1994 | 8299552 |
| [bacteriologic examinations of patients with burns]. | bacteriological studies were performed on 189 patients treated during 1985-1989. 800 samples were tested which were taken from various sites of burn wound (3-5 smears from a patient). surface of burn amounted to 15-86% and degree of burn was iib/iii. in 772 samples, 2073 bacterial strains were found. most frequent were pseudomonas aeruginosa (31%) and staphylococcus aureus (29%). remaining strains consisted chiefly of proteus mirabilis, pseudomonas cepacia, klebsiella pneumoniae, escherichia col ... | 1993 | 8309304 |
| estramustine potentiates the effects of irradiation on the dunning (r3327) rat prostatic adenocarcinoma. | the present study was designed to determine if estramustine phosphate (emp) could potentiate the effects of irradiation on the dunning (r3327) prostatic adenocarcinoma in rats. two groups of male copenhagen x fisher f1 rats carrying bilateral tumors in the flank were used. irradiation was given with a linear accelerator 6 mv, in a dose of 6 gy/day for 4 days to the tumor on one side while the tumor on the other side served as control. emp (360 micrograms/24 hours) was administered with osmotic p ... | 1994 | 8309847 |
| pediatric lung transplantation: expanding indications, 1985 to 1993. | the application of lung transplantation to the pediatric population was a natural extension of the success realized in our adult transplant program, which began in 1982. thirty-two pediatric patients (age range 1 to 18 years) have undergone heart-lung (n = 16), double-lung (n = 14), and single-lung (n = 2) transplantation procedures. the cause of end-stage lung disease was primary pulmonary hypertension (n = 7), congenital heart disease (n = 7), cystic fibrosis (n = 9), pulmonary arteriovenous m ... | 1993 | 8312344 |
| vesicular fast axonal transport rates in young and old rat axons. | an isolated sciatic nerve preparation was used to measure the transport rates of more than 18,000 vesicles in 72 axons from young (3-4 months of age) and old (24-26 months of age) rats from two strains (harlan sprague-dawley and fisher-344). average anterograde and retrograde vesicle transport rates were significantly slower in the older animals. the amount of slowing of anterograde vesicles was twice as great as the slowing of retrograde vesicles. age-related slowing of vesicle transport was in ... | 1993 | 8313149 |
| [facial angioma and the sturge-weber syndrome: a study of 121 cases]. | we show a study in 121 patients with port-wine stain (pws) over the areas of trigeminal nerve sensory innervation, and we analyzed the relations between this distribution, sex and the neuro-ocular disease. | 1993 | 8315969 |
| visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. | docosahexaenoic acid (dha; 22:6n-3) is important for normal visual development. we hypothesized that preterm infants fed formulas with marine oil as a source of dha would have better visual acuity than infants fed formulas without marine oil, as measured by the teller acuity card procedure. marine oil (p < 0.001) and age (p < 0.0001) influenced visual acuity, by repeated-measures analysis of variance (anova) corrected for the effect of subject. marine-oil-supplemented infants had better visual a ... | 1993 | 8317386 |
| [clinical analysis of paralytic shellfish poisoning following ingestion of oysters]. | we describe five patients of paralytic shellfish poisoning (psp) following ingestion of oysters in january 1991, in nagato, yamaguchi. the five patients (four men and one woman, age range:37-80 years) developed symptoms three-nine hours after consuming oysters. symptoms included paresthesia of the mouth and tongue (three), paresthesia of the extremities (five), and quadriparesis (five). the median duration of neurological symptoms was 16 hours. all five patients completely recovered. although ps ... | 1993 | 8319395 |
| anionic sites in glomerular basement membrane of rats with serum sickness nephritis: quick-freezing and deep-etching study. | serum sickness nephritis was induced in male fisher 344/jcl rats by injecting egg albumin into the foot pads and peritoneal cavity. the alteration of anionic sites in the glomerular basement membrane (gbm) of the rats with significant proteinuria was studied with a quick-freezing and deep-etching method using polyethyleneimine as a cationic probe. in control rats, anionic sites were located around the fibrils of the lamina rara externa, which radiated perpendicularly from the lamina densa to pod ... | 1993 | 8320129 |
| the assessment of iadl motor skills: an application of many-faceted rasch analysis. | traditional methods of developing tests have been driven by item content specification and have relied on the use of summed ordinal scores in an attempt to create a quantitative index of ability. there are fundamental problems with this approach to test development. the first problem is that the summing of qualitative ordinal counts to create a total score does not result in a number that is a valid means of making quantitative comparisons of performances. the second problem is that reliance on ... | 1993 | 8322873 |
| inhibition of the catechol-o-methyltransferase-catalyzed o-methylation of 2- and 4-hydroxyestradiol by catecholamine: implications for the mechanism of estrogen-induced carcinogenesis. | catechol estrogens have been postulated to mediate estrogen-induced carcinogenesis. as part of our examination of this hypothesis, we studied the catechol-o-methyltransferase-catalyzed o-methylation of 2- and 4-hydroxyestradiol and the inhibition of this reaction by catecholamines. epinephrine, norepinephrine, or dopamine (2 microm) inhibited the methylation of 2- and 4-hydroxyestradiol (20 mm) catalyzed by porcine liver catechol-o-methyltransferase by approximately 28-46% and 37-57%, respective ... | 1993 | 8323288 |
| [pathogenetic and clinical aspects of fisher syndrome]. | fisher syndrome has a triad of signs: ophthalmoplegia, ataxia and areflexia. in view of the evidence of peripheral nervous system involvement it resembles atypical forms of the guillain-barré syndrome. in 1956 fisher isolated the syndrome as a separate nosological entity calling attention to involvement of central structures. the review of the reports on the syndrome suggests that its pathological mechanism is mixed, with involvement of peripheral and central structures. | 2015 | 8327044 |
| enhanced response to daunomycin of normal, tumor and metastatic cell lines via drug photoactivation. | we have compared the cytotoxicity of daunomycin in vitro to highly differentiated normal epithelial cells (fisher rat thyroid cells, frtl-5) and to two neoplastic cell lines, a thyroid carcinoma (tk-6) and its lung metastasis (mptk-6). whereas the cell lines are equally sensitive to the drug in the dark, if irradiated during incubation with daunomycin (86 j/cm2 at 488 nm), they become more and differently sensitive. namely, the drug doses producing 50% mortality decrease by factors of about 22, ... | 1993 | 8337260 |
| miller fisher syndrome mimicking stroke in immunosuppressed patient with rheumatoid arthritis responding to plasma exchange. | a patient with rheumatoid arthritis on immunosuppressive therapy was admitted to hospital with the sudden onset of diplopia and ataxia. because of the history, a stroke was thought most likely. however, as he progressed a diagnosis of the miller fisher syndrome was established. he responded to plasma exchange. this presentation is highly unusual and has not previously been described. in addition, the possibility of immune dysregulation setting the stage for the development of this syndrome is di ... | 1993 | 8340481 |
| pediatric miller fisher syndrome requiring intubation: a case report. | in 1956, c. miller fisher described a clinical syndrome of ophthalmoplegia, ataxia, and areflexia. this syndrome, which now bears his name, shares certain features with the guillain-barré syndrome (gbs) and generally follows a benign, restricted clinical course, especially in the pediatric population. the authors report a pediatric case of miller fisher syndrome (mfs) who subsequently required intubation and mechanical ventilation. | 1993 | 8344052 |
| immunohistochemical localization of epidermal growth factor and transforming growth factor alpha in the male rat accessory sex organs. | we examined the presence of epidermal growth factor (egf) and transforming growth factor alpha (tgf alpha) in the prostate (ventral, lateral, dorsal lobes), coagulating gland and seminal vesicle of fisher 344 adult male rats by immunohistochemical and radioimmunoassay methods. immunohistochemically demonstrable egf was localized in the luminal secretion only of the dorsal lobe of the prostate. reactive tgf alpha was localized in the lateral lobe (100% of epithelial cells), dorsal lobe (about 40% ... | 1993 | 8345628 |
| effect of age on survival in acute leukemia. 1950-1990. | four decades ago, survival of patients with acute leukemia was brief at any age. since 1950, survival of children has increased remarkably but has changed little for the elderly. the nature and magnitude of this age difference in survival are not understood. | 1993 | 8348491 |
| impact of prematurity and intrauterine growth retardation on neonatal hemorrhagic and ischemic brain damage. | low birth weight and intrauterine growth retardation are well-recognized risk factors for increased mortality, morbidity and poor neurologic outcome. risk assessment is different considering true preterm (appropriate-for-gestational-age, aga) or growth-retarded (small-for-gestational-age, sga) infants. therefore, we carried out a study on the incidence of hemorrhagic (peri-intraventricular hemorrhage, pivh) and ischemic (periventricular leukomalacia) brain lesions in two groups of aga and sga ve ... | 1993 | 8348917 |
| application of a simple mechanical model of accommodation to the aging eye. | a simple model for the mechanics of accommodation in the human eye, previously proposed, is applied to the eye at different ages. data from work by r. f. fisher is used to derive values for the elasticity of lens-plus-zonules and data from work by g. w. h. m. van alphen and w. graebel is used to derive values for the elasticity of the choroid, each at a series of ages. the model is applied in two ways: (i) the elasticity of one component is allowed to change with age, while the other (and also c ... | 1993 | 8351845 |
| performances on the nbme i, ii, and iii by medical students in the problem-based learning and conventional tracks at the university of new mexico. | problem-based learning curricula are growing in popularity, and questions have been raised about the appropriateness of standardized examinations, such as the national board of medical examiners (nbme) parts i, ii, and iii examinations, for assessing students in these new curricula. | 1993 | 8352874 |
| cerebral hemodynamics in subarachnoid hemorrhage evaluated by transcranial doppler sonography. part 2. pulsatility indices: normal reference values and characteristics in subarachnoid hemorrhage. | in previous publications on the diagnostic value of transcranial doppler sonography (tcd), conflicting results concerning predictive capacities for evaluating vasospasm by measuring flow velocities were reported, and the necessity to examine pulsatility indices (pis) was stressed. pis are known to give useful information on cerebral hemodynamics in cases of stenosis of the extracranial internal carotid artery and cerebral arteriovenous malformations. whether the examination of pis can give addit ... | 1993 | 8355825 |
| neuropsychiatric disease in sjögren's syndrome: anti-ribosomal p and anti-neuronal antibodies. | patients with sjögren's syndrome (ss) may develop nonfocal (i.e., psychiatric and/or cognitive dysfunction) as well as focal, neuropsychiatric disease (cns-ss). anti-ribosomal p and anti-neuronal antibodies have been associated with nonfocal neuropsychiatric disease in systemic lupus erythematosus (sle), particularly psychosis and depression. this study examines the spectrum of psychiatric and cognitive dysfunction observed in ss patients with focal, as well as nonfocal, central nervous system ( ... | 1993 | 8356981 |
| estrogenic regulation of proenkephalin mrna expression in the ventromedial hypothalamus of the adult male rat. | endogenous opioid peptides and their receptors are regulated by gonadal steroid hormones in the rat hypothalamus. recent evidence suggests that gonadal steroids are capable of regulating the expression of proenkephalin (pe) mrna in the ventromedial hypothalamus (vmh) of female, but not male rats. therefore, we examined the effect of gonadectomy with or without four weeks of hormone treatment on pe mrna expression in adult male fisher 344 rats using quantitative in situ hybridization histochemist ... | 1993 | 8361335 |
| effect of acetyl-l-carnitine treatment on brain adenylate cyclase activity in young and aged rats. | the aim of the present study has been to evaluate the effect of acetyl-l-carnitine (alcar) on brain adenylate cyclase (ac) activity in adult and aged rats. in in vitro studies, alcar (1, 10 and 100 microm) did not exert any effect on frontal cortex basal ac activity. acute and subchronic administrations of alcar were carried out in 4- and 25-month-old male fisher rats and ac activity was determined in rat frontal cortex under both basal and stimulated conditions. the acute treatment of young rat ... | 1993 | 8364354 |
| experimental ileitis in dogs and colitis in rats with trinitrobenzene sulfonic acid--colonoscopic and histopathologic studies. | using a novel experimental model of chronic enterocolitis described by morris et al., we observed sequential changes of mucosal lesions endoscopically and performed histopathological studies. fisher rats were rectally administered 25 mg of trinitrobenzene sulfonic acid (tnbs) dissolved in 0.5 ml of 50% ethanol (et). the combination treatment of tnbs and et produced colitis in rats for over 3 weeks. tnbs itself did not induce any lesions. et alone induced mucosal lesions, but their severity was m ... | 1993 | 8375625 |
| modulation by aging of the coronary vascular response to endothelin-1 in the rat isolated perfused heart. | changes with age in the coronary vascular response to endothelin-1 were investigated in perfused hearts isolated from 2-, 6- and 24-month-old (mo) male fisher-344 rats. endothelin-1 injected as a single bolus (0.3, 3 and 30 nmol) into the coronary artery supply caused dose-dependent vasoconstriction in all three age groups. while there was no age-related change in the vasoconstriction induced by the lower doses (0.3 and 3 nmol), the higher dose (30 nmol) elicited a more pronounced vasoconstricti ... | 1993 | 8377844 |
| inhibition of growth of experimental prostate cancer in rats by lh-rh analogs linked to cytotoxic radicals. | the effects of hybrid cytotoxic lh-rh analogs, produced by linking anthraquinone or methotrexate to carrier lh-rh agonist [d-lys6]lh-rh, were evaluated in copenhagen-fisher f1 rats bearing dunning r-3327h prostate adenocarcinoma. the two cytotoxic lh-rh analogs t-98 [(d-lys6)lh-rh coupled to glutaryl-2-(hydroxymethyl)anthraquinone (g-hmaq)], and aj-04 [(d-lys6)lh-rh linked to methotrexate (mtx)], carrier [d-lys6]lh-rh, or the free cytotoxic compounds mtx and g-hmaq were administered from alzet o ... | 1993 | 8378189 |
| early detection of acute allograft rejection in rat heart transplantation: flowcytometric monitoring of interleukin 2 receptor expression on cd8 positive lymphocytes. | to assess the usefulness of flowcytometric monitoring in the early detection of acute allograft rejection, we studied surface markers of graft infiltrating lymphocytes, coronary sinus blood lymphocytes and peripheral blood lymphocytes after rat heart transplantation. fisher rats served as donors and lewis rats as recipients. among recipients that received no immunosuppression, grafts were removed 2 days after transplantation (ongoing rejection group: n = 7) and on the day of terminal rejection ( ... | 1993 | 8379342 |
| experimental carcinomatous plexopathy. | to understand the pathophysiology of carcinomatous plexopathy better, we studied nerve lesions induced by an experimental thyroid carcinoma implanted over the brachial plexus in 30 fisher rats. we performed a morphological study including light and electron microscopic examination and teased fibre preparations of brachial plexuses from implanted and control animals. the control side was normal in all. a large tumour always grew within 2 months in all implanted animals and a third of the rats eve ... | 1993 | 8380847 |
| brainstem encephalitis and the miller fisher syndrome. | a case is described of a man with an acute onset areflexic ataxic syndrome with partial ophthalmoparesis and normal limb muscle power. there was evidence of both a peripheral neuropathy and a brainstem encephalitis. the patient made a full recovery and the interrelationship and nosology of brainstem encephalitis and the miller fisher syndrome are discussed. | 1993 | 8382270 |
| novel hela topoisomerase ii is the ii beta isoform: complete coding sequence and homology with other type ii topoisomerases. | dna topoisomerase (topo) ii mediates dna strand passage in an atp-dependent reaction. human cell lines express at least two genetically distinct forms of the enzyme, topo ii alpha (p170) and ii beta (p180). previously, we isolated a novel hela cdna clone (caa5) that partially encodes a protein homologous to topo ii alpha (austin, c.a. and fisher, l.m. (1990) febs lett. 266, 115-117). in this paper we show that caa5 encodes a c-terminal segment of human topo ii beta. we report here for the first ... | 1993 | 8383537 |
| therapeutic effects of a human antiflagella monoclonal antibody in a neutropenic murine model of pseudomonas aeruginosa pneumonia. | human immunoglobulin g1 (igg1) monoclonal antibodies (mabs) reactive with type-specific pseudomonas aeruginosa lipopolysaccharide (lps) and flagella were compared for their protective activities against fisher immunotype 2 p. aeruginosa pneumonia in neutropenic mice. the activity of the antiflagella mab at a dose of 500 micrograms per mouse was comparable to that of the anti-lps mab at the same dose. in vivo protection was correlated with bacterial density in the lung tissue and blood of infecte ... | 1993 | 8383936 |
| the characterization of adenyl cyclase activity in frtl-5 cell line. | the purpose of this study is to characterize the adenyl cyclase (ac) activity in fisher rat thyroid cell line when stimulated with several agonists, such as: forskolin, sodium fluoride, gpp(nh)p (guanosine-5'-(beta, gamma -imino) triphosphate or thyrotropin. the following studies such as: dose-response, ph, temperature, time-response, millieu concentration, 3h-thymidine uptake, km and vm study were also performed. adenyl cyclase activity was measured as adenosine 3', 5'-cyclic monophosphate gene ... | 1993 | 8387868 |
| cloning, sequencing, and expression of the dna gyrase genes from staphylococcus aureus. | we have isolated and cloned the gyra and gyrb genes from staphylococcus aureus. these adjacent genes encode the subunits of dna gyrase. the nucleotide sequence of a 5.9-kb region which includes part of an upstream recf gene, the whole of gyrb and gyra, and about 1 kb of unknown downstream sequence has been determined. the gyrb and gyra gene sequences predict proteins of 886 and 644 amino acid residues, respectively, which have significant homologies with the gyrase subunits of escherichia coli a ... | 1993 | 8388872 |
| chronic inhalation toxicity of size-separated glass fibers in fischer 344 rats. | this study was initiated to determine the chronic biological effects in fisher 344 rats of inhaled size-separated respirable fractions of fibrous glass (fg) having compositions representative of common building insulation wools. rats were exposed using nose-only inhalation chambers, 6 hr/day, 5 days/week, for 24 months to three concentrations (3, 16, and 30 mg/m3) of two different compositions of fg (designated mmvf 10 and mmvf 11), or to filtered air (negative control). fibrous glass findings w ... | 1993 | 8390950 |
| anogenital warts in children. | fourteen children presenting with anogenital (ag) warts and their close family members were studied; 28.6 and 8.3% of presenting children and other child household members, respectively, had non-genital cutaneous warts; 42.8% of children with ag warts had one or more adult household member with common hand warts. fifty per cent of all mothers had subclinical cervical papilloma virus (pv) infection; only one male adult had subclinical pv infection of the penis without concurrent ag warts. of the ... | 1993 | 8394232 |
| induction of malignant fibrous histiocytoma in female fisher rats by implantation of cyanoacrylate, zirconia, polyvinyl chloride or silicone. | five kinds of foreign bodies (silicone, cellulose, polyvinyl chloride, zirconia and alkyl-alpha cyanoacrylate) were implanted into subcutaneous tissue of female fisher rats. subcutaneous tumors were induced in 27.3, 54.5, 100, 63.6% of rats by silicone rubber, polyvinyl chloride, zirconia and alkyl-alpha-cyanoacrylate, respectively, but not by cellulose. almost all tumors were composed of a mixture of cells that resembled fibroblasts characterized by the presence of numerous rough-surfaced endop ... | 1993 | 8395906 |
| tumor uptake of 99mtc-mibi and 201tl by a 9l gliosarcoma brain tumor model in rats. | there have been several recent case reports of the accumulation of 99mtc-mibi [hexakismethoxyisobutylisonitriletechnetium(i), cardiolite, sestamibi] in tumors, but no reports of the uptake of this radiopharmaceutical in an animal model. to address this question, the biodistributions of 99mtc-mibi and 201tl were compared in fisher rats bearing 9l gliosarcomas. the results showed that, although the absolute uptake of the tracers by the tumor is relatively low (< 1% id/g), the tumor-to-normal brain ... | 1993 | 8401378 |
| correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro. | for many acute-acting chemicals, toxic responses observed in vivo correlate strongly with metabolic activation and macromolecular covalent binding (cvb) observed in vitro and often in vivo; bromobenzene (bb) is a classic example of this behavior. substituent groups modulate the toxicity of bromobenzene in vivo and in liver slices cultured in vitro in parallel fashion [fisher, r., hanzlik, r.p., gandolfi, j.a., and brendel, k. (1992), in vitro toxicology, 4, 173-186]. in the present study we used ... | 1993 | 8403079 |
| k-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during azoxymethane-induced colon carcinogenesis. | ras mutations are an important early event in a number of carcinogen-induced rodent tumors. colon carcinogenesis induced in rats by azoxymethane is a useful model as it mimics the adenoma-carcinoma sequence observed in humans. in addition, aberrant crypt foci develop in the rat and these lesions appear to be potentially important precursors to adenomas in colorectal cancer. recent studies have shown that specific k-ras codon 12 and 13 mutations are present in up to 66% of carcinogen-induced rat ... | 1993 | 8403199 |
| regulation of resistance against adjuvant arthritis in the fisher rat. | inbred female lewis (lew/n) rats develop a severe chronic arthritis in the adjuvant arthritis (aa) model, histocompatible fisher (f344/n) rats are resistant and germ-free fishers (gf f344) are again susceptible. in this study we show that the f344 rat can become susceptible to aa, using mycobacterium tuberculosis (m.tb.) in the powerful adjuvant paraffin oil, instead of mineral oil (freund's incomplete adjuvant (fia)). this indicates that the f344 rat does not lack t effector cells. to examine f ... | 1993 | 8403498 |
| enzyme activities and crystallin profiles of clear and cataractous lenses of the rcs rat. | royal college of surgeons (rcs) rats have hereditary retinal degeneration in association with posterior subcapsular opacities. cataract formation is thought to be correlated with an increase in lipid peroxidation products in the vitreous (zigler and hess, 1985). in order to examine the possibility that parallel changes in enzyme activity are occurring within the lens, we analysed the activity of four key enzymes and the crystallin protein profile. we compared rcs rat lenses at three different st ... | 1993 | 8405188 |
| the human bone sialoprotein gene (ibsp): genomic localization and characterization. | we have isolated and partially sequenced the human bone sialoprotein gene (ibsp). ibsp has been sublocalized by in situ hybridization to chromosome 4q28-q31 and is composed of six small exons (51 to 159 bp) and 1 large exon (approximately 2.6 kb). the intron/exon junctions defined by sequence analysis are of class o, retaining an intact coding triplet. sequence analysis of the 5' upstream region revealed a tataa (nucleotides -30 to -25 from the transcriptional start point) and a ccaat (nucleotid ... | 1993 | 8406493 |
| 20-year experience in childhood craniopharyngioma. | the management of craniopharyngioma is controversial, and surgery alone is frequently advocated. the purpose of this study was to assess the long-term impact of various treatments in childhood craniopharyngioma. | 1993 | 8407391 |
| meniscal transplantation using fresh and cryopreserved allografts--an experimental study in the genetically defined rat. | the purpose of this study is to examine the possibilities of meniscal allograft and the effects of cryopreservation on grafts in rats (lewis and fisher). transplants were carried out on three minor mismatched groups of rats with: 1) 16 fresh meniscal allografts, 2) 16 fresh meniscal allografts with immunosuppression, and 3) 16 cryopreserved meniscal allografts. as a control, 16 fisher rats received isograft menisci transplants. four transplanted grafts each were evaluated histologically 4, 8, 12 ... | 1993 | 8409637 |
| [the incidence, localization, sex and mean age in patients with renal carcinoma]. | retrospective analysis was made of the clinical case records of 97 nephrectomized patients with renal cancer at the university urologic clinic in rostock, germany. the student-fisher t-criterion was used for statistical processing of the results. the stage of the disease was determined in accordance with the histologic classification of ptnm, suggested in 1988 by the european organization for cancer research and treatment. patients with malignant diseases of the urogenital tract accounted for 6. ... | 1993 | 8411862 |
| tumor-induced alterations in hepatic malic enzyme and carnitine palmitoyltransferase activity. | to better understand the role of the liver in the hypertriglyceridemia observed in a tumor-bearing state, we have examined tumor-induced alterations in hepatic lipogenesis and fatty acid oxidation. the effects of differing tumor burden as well as tumor excision on the activity and mrna levels of malic enzyme and carnitine palmitoyltransferase were studied in fisher 344 rats bearing a methylcholanthrene-induced sarcoma. serum triacylglycerols and plasma nonesterified fatty acids (nefa) levels wer ... | 1993 | 8412123 |
| serum anti-gq1b igg antibody is associated with ophthalmoplegia in miller fisher syndrome and guillain-barré syndrome: clinical and immunohistochemical studies. | to determine the significance of serum anti-gq1b igg antibody, we studied the disease spectrum associated with this antibody and gq1b epitope in the human nervous system. we examined sera from 19 patients with typical miller fisher syndrome (mfs), five patients with acute postinfectious ophthalmoplegia without ataxia (atypical mfs), six patients with guillain-barré syndrome (gbs) with ophthalmoplegia (gbs-op[+]), and 23 patients with gbs without ophthalmoplegia (gbs-op[-]). we also examined sera ... | 1993 | 8413947 |
| [the incidence, etiology and clinical significance of visceral mycoses in patients with aids]. | the incidence, aetiology and clinical significance of visceral mycoses in hiv-infected subjects were evaluated by a retrospective survey of the clinical and microbiological records of 237 consecutive aids patients followed-up since 1984. seventy-four patients out of 237 (31.2%) (56 males, 18 females; 55 iv drug abusers, 7 heterosexuals, 6 homobisexuals, 3 blood recipients and 3 children with congenitally-acquired hiv infection) presented 77 different episodes of visceral fungal infection as a wh ... | 1993 | 8414130 |
| value of having a cytopathologist present during percutaneous fine-needle aspiration biopsy of lung: report of 55 cancer patients and metaanalysis of the literature. | percutaneous fine-needle aspiration biopsy is an accepted procedure for diagnosing intrathoracic malignant disease. the value of having a cytopathologist present during the procedure was studied with respect to the number of needle passes, the accuracy of the procedure, and complications. a metaanalysis was performed on the combined results of the present and previous series. | 1993 | 8416620 |
| the efficacy of combination immunotherapy in experimental pseudomonas sepsis. | immunotherapy has been shown to be an effective adjuvant in the management of septic shock. a neutropenic rat model of septic shock induced by infection with pseudomonas aeruginosa 12.4.4 (fisher immunotype 6) was used to determine the relative efficacy of single, double, and triple combination immunotherapy. a pseudomonas o serotype-specific, opsonophagocytic monoclonal antibody (mab), polyclonal j5 antiserum, and a mab directed against tumor necrosis factor-alpha (tnf) were studied as single t ... | 1993 | 8418157 |
| energy restriction reduces metabolic rate in adult male fisher-344 rats. | energy restriction, without malnutrition, prolongs the maximum life span of laboratory rodents. a reduction in metabolic rate has been proposed as a potential mechanism for increased longevity. the present study examines changes in metabolic rate of adult rats after a 6-wk period of energy restriction. two groups (n = 6) of 6-mo-old male fisher-344 rats were studied. restricted rats were pair-fed a diet equivalent in vitamins and minerals but restricted to 60% of energy consumed by rats eating a ... | 1993 | 8421235 |
| locomotion and physical development in rats treated with ionizing radiation in utero. | effects of ionizing radiation on the emergence of locomotor skill, and physical development were studied in laboratory rats (fisher f-344 inbred strain). rats were treated with 3 different doses of radiation (150 rad, 15 rad, and 6.8 rad) delivered on the 20th day of prenatal life. results indicated that relatively moderate (15 rad) to high (150 rad) doses of radiation had effects on certain locomotion and physical development parameters. exposure to 150 rad delayed pivoting, cliff-avoidance, up ... | 1993 | 8426060 |
| dna ploidy and percent s-phase as prognostic factors in node-positive breast cancer: results from patients enrolled in two prospective randomized trials. | to help clarify the clinical utility of flow-cytometric parameters, we performed flow cytometry on archival paraffin-embedded primary breast cancers from 502 patients treated on two adjuvant chemotherapy protocols performed by the north central cancer treatment group (ncctg) and mayo clinic. dna ploidy and percent s-phase (%s) were examined in univariate and cox model multivariate analyses along with tumor size, menopausal and estrogen receptor status, quetelet's index (qi), number of positive n ... | 1993 | 8426213 |
| [antiribosomal antibodies and the neurological manifestations in systemic lupus erythematosus]. | the possible positive correlation between the presence of antiribosomic antibodies and neurologic and neuropsychiatric manifestations in patients with systemic lupus erythematosus, cited in the literature, was analyzed. | 1993 | 8426498 |
| paragangliomas. static cytometric studies of nuclear dna patterns. | the biologic behavior of most paragangliomas cannot be predicted from their histologic appearance. recently, cytometric studies have found an association between an aggressive clinical behavior and the presence of a hyperdiploid or tetraploid range in the dna nuclear content. | 1993 | 8431863 |
| characterization of specific binding of a human immunoglobulin m monoclonal antibody to lipopolysaccharide and its lipid a domain. | the human immunoglobulin m monoclonal antibody ha-1a was first described as an antibody which bound specifically to the lipid a region of lipopolysaccharide (lps) (n. n. h. teng, h. s. kaplan, j. m. herbert, c. moore, h. douglas, a. wunderlich, and a. braude, proc. natl. acad. sci. usa 82:1790-1794, 1985) and provided significant protection when administered to patients with gram-negative bacteremia and shock (e. j. ziegler, c. j. fisher, jr., c. l. sprung, r. c. straube, j. c. sadoff, g. e. fou ... | 1993 | 8432611 |
| prospective study on the prevention of cerebral vasospasm by intrathecal fibrinolytic therapy with tissue-type plasminogen activator. | the authors have evaluated the efficacy of postoperative intrathecal injections of tissue-type plasminogen activator (tpa) in preventing cerebral vasospasm in patients with a diffuse thick subarachnoid hemorrhage (sah). the present study examined 105 patients who underwent direct surgery within 48 hours of sah and whose computerized tomography (ct) findings were classified as fisher ct group 3. patients showing diffuse thick subarachnoid blood clots on ct with greater than 75 hounsfield units (h ... | 1993 | 8433145 |