Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| effects of alpha-chymotrypsin on the outflow routes for aqueous humor. | the anterior chamber was perfused with alpha-chymotrypsin, 50 micrograms ml-1, in mock aqueous humor in cynomolgus monkeys. the enzyme caused a marked rise in outflow facility and had clear effects on the structure of the outflow routes for aqueous humor. the intertrabecular spaces in the iridocorneal chamber angle were wider than normal, the openings in the uveal and corneoscleral meshwork appeared enlarged, there was ballooning of the juxtacanalicular region and the inner wall of schlemm's can ... | 1988 | 3350074 |
| the nasotemporal division in primate retina: the neural bases of macular sparing and splitting. | in primates, each hemisphere contains a representation of the contralateral visual hemifield; unilateral damage to the visual pathways results in loss of vision in half of the visual field. apparently similar severe, unilateral lesions to the central visual pathways can result in two qualitatively different central visual field defects termed macular sparing and macular splitting. in macular sparing a 2 degrees to 3 degrees region around the fovea is spared from the effects of unilateral damage ... | 1988 | 3353708 |
| pharmacokinetics of proterguride in rat and cynomolgus monkey. | 1. the pharmacokinetics of proterguride were studied in rat and cynomolgus monkey using 3h- and 14c-labelled drug and a radioimmunoassay for concentration measurements of unchanged drug. 2. proterguride was rapidly and completely absorbed at low doses but not completely at higher dose levels, especially in rat. 3. bioavailability was 18% in the monkey (low and high doses) and 79% (low doses) and 38% (high dose), respectively, in the rat. 4. proterguride was able to pass the blood-brain barrier a ... | 1988 | 3354231 |
| influence of partial replacement of starch by sucrose in high fat-cholesterol diet on serum lipoprotein responses of cynomolgus monkeys. | the influence of partial replacement of starch by sucrose on dietary cholesterol-induced serum lipoprotein responses was examined in 10 male cynomolgus monkeys (macaca fascicularis). in a crossover design two semipurified diets provided either starch or starch and sucrose (1:1) as carbohydrate (49% by calories) with 0.4 mg cholesterol/kcal. six weeks of starch + sucrose diet resulted in significantly reduced levels (mean +/- se, mg/dl) of serum total cholesterol (264 +/- 9 vs 244 +/- 8) and apo ... | 1988 | 3355713 |
| dissociation of cholinergic supersensitivity from receptor number in ciliary muscle. | ciliary ganglionectomy in the cynomolgus monkey produced loss of the accommodative response to electrical stimulation of the edinger-westphal nucleus and to topical eserine, concurrent with enhanced responsiveness to topical and systemic pilocarpine. this supersensitivity produced by parasympathetic denervation was not associated with an increase in muscarinic receptor number or affinity measured using specific qnb binding sites in ciliary muscle homogenates. in seven of ten cases, ciliary muscl ... | 1988 | 3356516 |
| abnormal influences of passive limb movement on the activity of globus pallidus neurons in parkinsonian monkeys. | extracellular single unit activity was recorded in the globus pallidus of waking macaca fascicularis during passive limb movement. the main upper and lower limb joints were investigated bilaterally. the animals were either intact or rendered parkinsonian by the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp). cell counts showed that at least 90% of nigral neurons of the compacta-type were degenerated in the parkinsonian animals. in the intact animals, only 17% of the pallidal neur ... | 1988 | 3359286 |
| dose-response relationship between thyroid hormone and growth velocity in cynomolgus monkeys. | to investigate the dose-response relationship between thyroid hormone and linear growth, we studied 10 castrated prepubertal cynomolgus monkeys. hypothyroidism was induced by administration of methimazole (0.0125% in drinking water) and was confirmed by high serum tsh levels (greater than 40 mu/l) in all animals. subsequently, each animal received 1, 2, 4, or 8 micrograms/kg.day t4, im, for 9 weeks. the sequence of t4 doses was random, and 6 weeks elapsed between successive t4 doses. serum t4, t ... | 1988 | 3360894 |
| monkey pulvinar units related to motor activity and sensory response. | single neuron activity in the pulvinar (pu) was recorded in unanesthetized macaca irus to investigate the sensory-motor role of this nucleus. a cylinder cemented to the skull allowed microelectrode penetrations. the head was immobilized during recording. animals were trained to move a lever (push-pull). electromyographs (emgs) of several limb muscles were recorded together with pu unit activity. the effect of active and passive limb movements was studied. pu responses were also recorded during s ... | 1988 | 3365558 |
| [multivariate analysis of hematological and serum biochemical values in female cynomolgus monkeys (macaca fascicularis) aged less than a year]. | hematological and serum biochemical data obtained from 91 laboratory-bred cynomolgus monkeys (macaca fascicularis) aged 11 to 362 days were analyzed by the discriminant analysis. all animals used had been bred and reared under uniform environmental conditions at tsukuba primate center for medical science, n. i. h., japan. the examination items were as follows: red blood cell count (rbc), hematocrit value (ht), hemoglobin concentration (hb), mean corpuscular volume (mcv), white blood cell count ( ... | 1988 | 3366189 |
| biochemical characterization of prostaglandin 19-hydroxylase of seminal vesicles. | the microsomal fraction of homogenates of seminal vesicles of men and monkeys, macaca fascicularis, were analyzed for prostaglandin (pg) 19-hydroxylase activity. the microsomes of the monkey seminal vesicles, supplemented with 1 mm nadph, metabolized 0.2 mm pge1 to 19-hydroxy-pge1 at a mean rate of 0.26 nmol/min/mg of protein (with an apparent km and an apparent vmax of 40 microm and 0.30 nmol/min/mg of protein, respectively). the enzyme catalyzed the incorporation of atmospheric oxygen into the ... | 1988 | 3366775 |
| anabolic steroids and aggressive behavior in cynomolgus monkeys. | an animal model was employed to examine the effect of testosterone on aggressive behavior patterns. ten cynomolgus monkeys were assigned to either an experimental or a control group and given biweekly injections; the experimental group received testosterone propionate, and the controls a sham solution. prior to and upon the completion of an 8-week treatment period, behavioral observations were conducted. although the administration of testosterone resulted in a significant increase in aggression ... | 1988 | 3367374 |
| cutaneous mycobacterium avium infection in a cynomolgus monkey. | 1988 | 3367629 | |
| the surface morphology of normal and atherosclerotic coronary arteries in male macaca fascicularis and the effect of coronary angiography. | selective coronary angiography is one of the procedures used frequently in the diagnosis and management of coronary artery disease. macaca fascicularis monkeys were used to study the effects of coronary angiography on coronary artery surface morphology. fourteen m. fascicularis were fed either an atherogenic diet (0.34 mg of cholesterol/kcal and 40 to 43% of the calories as fat) for six to nine months or a control diet. for six of these animals the judkin method of selective left coronary angiog ... | 1988 | 3368768 |
| pulmonary elastic fiber degradation in paraquat toxicity. an electron microscopic immunohistochemical study. | to study the morphologic alterations of pulmonary elastic fibers in cynomolgus monkeys with paraquat toxicity, peroxidase- and ferritin-labeled antielastin antibodies were used for the light and electron microscopic localization of elastin. one week after paraquat, alveolitis, tissue damage and alveolar dilatation were present; elastic fibers were frayed and more diffusely and intensely stained than those of control animals. in the latter, staining was localized in peripheral regions of the amor ... | 1988 | 3370614 |
| the toxicology of gossypol acetic acid and (-)-gossypol. | the toxicity of gossypol has been investigated in sprague-dawley rats at dosages of 0, 0.5, 5.0 and 25 mg/kg per day of (+/-)-gossypol acetic acid. the most significant toxicological finding was marked suppression of body weight gain in rats receiving 25 mg/kg per day. terminal studies showed 6 out of 20 rats receiving 25 mg/kg per day to have varying degrees of testicular pathology. five mg/kg per day was shown to be a "no effect" level. a study in cynomolgus monkeys at 25 mg/kg per day of (+/- ... | 1988 | 3370991 |
| equivalent potency and pharmacokinetics of recombinant human growth hormones with or without an n-terminal methionine. | two forms of human gh (hgh) have been produced by recombinant dna technology. one form has an amino acid sequence identical to that of the natural pituitary hormone (rhgh) and the other form has an additional n-terminal methionine (met-hgh). the biological potencies of these 2 polypeptides have been compared in hypophysectomized rats in a multidose study measuring body weights and several long bone growth parameters. the pharmacokinetic profiles after iv and sc injection were determined in cynom ... | 1988 | 3371267 |
| studies of psychosocial influences on coronary artery atherogenesis in cynomolgus monkeys. | the cynomolgus macaque provides a suitable primate model for studying how psychosocial factors contribute to coronary artery atherogenesis. important interactions with diet, sex, and behaviorally elicited cardiovascular reactivity are described. | 1988 | 3371304 |
| naturally occurring chronic gastritis and c pylori infection in the rhesus monkey: a potential model for gastritis in man. | histological examination of the stomachs of rhesus monkeys at autopsy showed chronic gastritis in a high proportion of all ages. lesions consisted of mild to heavy infiltration of the lamina propria by lymphocytes, plasma cells, and histiocytes. the antrum was most consistently affected, but lesions were also present in the fundus and pylorus. gastric campylobacter-like organisms (gclo) apparently identical to human c pylori were cultured and/or detected immunohistologically in several animals. ... | 1988 | 3371715 |
| ocular toxoplasmosis in immunosuppressed nonhuman primates. | to investigate the role of cellular immunodeficiency in recurrent toxoplasmic retinochoroiditis, six cynomolgus monkeys (macaca fascicularis) with healed toxoplasmic lesions of the retina were immunosuppressed by total lymphoid irradiation. three months prior to irradiation 30,000 toxoplasma gondii organisms of the beverley strain had been inoculated onto the macula of eye in each monkey via a pars plana approach. toxoplasmic retinochoroiditis developed in each animal, and lesions were allowed t ... | 1988 | 3372160 |
| normal serum ige and igg antibody levels in adult male cynomolgus monkeys. | 1988 | 3374098 | |
| lymphoma of the pharynx and abdominal wall in two cynomolgus monkeys. | 1988 | 3374099 | |
| innervation of crab-eating monkey trachealis muscle determined in vitro. | strips of smooth muscle from the cervical tracheae of six adult male crab-eating monkeys (macaca fascicularis) were studied in jacketed 25 ml organ baths filled with krebs-bicarbonate solution maintained at 37 degrees c and gassed with 5% co2 in oxygen. isometric tissue tension increased in response to electrical field stimulation (18 v, 25 hz, 0.5 msec), norepinephrine in the presence of propranolol, acetylcholine and histamine. atropine abolished the contractile response to electrical stimulat ... | 1988 | 3375607 |
| a dihydropyridine conjugate which generates high and sustained levels of the corresponding pyridinium salt in the brain does not exhibit neurotoxicity in cynomolgus monkeys. | many drugs can be selectively delivered to the brain by using a dihydropyridine in equilibrium pyridinium salt chemical delivery system (cds). the interaction of these systems with central dopaminergic function was examined in this communication. castrate female sprague-dawley rats when treated with a cds for estradiol (i.e. 3-hydroxy-17 beta-[( (1-methyl-1,4-dihydropyridin-3-yl)carbonyl]oxy) estra-1,3,5(10)-triene or e2cds) exhibit sustained and profound suppression of serum levels of leuteiniz ... | 1988 | 3380349 |
| structure determination of metabolites of rilmazafone, a 1h-1,2,4-triazolyl benzophenone derivative in monkey urine. | 1. the metabolism of a new hypnotic 5-[(2-aminoacetamido)methyl]- 1-[4-chloro-2-(o-chlorobenzoyl)phenyl]-n,n-dimethyl-1h-1,2,4-tr iaz ole-3-carboxamide hydrochloride dihydrate (rilmazafone hydrochloride) was studies in female cynomolgus monkeys. 2. the structures of ten urinary metabolites were determined by mass spectrometry, and confirmed by comparison with synthetic authentic compounds. 3. pathways of metabolism are postulated indicating that rilmazafone is desglycylated and cyclized to m-1, ... | 1988 | 3381539 |
| complement activation in cardiopulmonary bypass, with special reference to anaphylatoxin production in membrane and bubble oxygenators. | complement activation by cardiopulmonary bypass (cpb) was studied in 82 patients divided into membrane (mog) and bubble oxygenator groups (bog). the influence of primed homologous to circulating autologous blood volume (h/a) ratio was also evaluated. c4a increased very slowly during cpb in both groups, maintaining slightly higher levels in the bog than in the mog, with the exception of a marked initial rise in the bog with a high h/a ratio (greater than or equal to 20%). anaphylatoxin c3a levels ... | 1988 | 3382287 |
| activity of primate magnocellular red nucleus related to hand and finger movements. | single cells were recorded in the magnocellular red nucleus (rnm) of two cynomolgus monkeys using tungsten microelectrodes. the first monkey was trained to press finger switches and to operate a push-pull device. comparison of responses while operating the two devices demonstrated a strong distal bias. the finger device elicited large modulations in discharge (greater than or equal to 50 impulses/s) in 75% of the sampled neurons. most cells fired optimally during thumb switch operation, but also ... | 1988 | 3382512 |
| visuotopic organization and extent of v3 and v4 of the macaque. | the representation of the visual field in areas v3 and v4 of the macaque was mapped with multiunit electrodes. twelve macaca fascicularis were studied in repeated recording sessions while immobilized and anesthetized. v3 is a narrow strip (4-5 mm wide) of myeloarchitectonically distinct cortex located immediately anterior to v2. it contains a systematic representation of the central 35-40 degrees of the contralateral visual field; the representation of the upper quadrant is located ventrally in ... | 1988 | 3385477 |
| adverse pregnancy outcome in the monkey (macaca fascicularis) after chronic caffeine exposure. | caffeine and the related methylxanthine theophylline are consumed regularly by pregnant women. in a study originally designed to assess the neurotoxic potential of caffeine in the infant, 40 female monkeys (macaca fascicularis) were divided into three groups and administered caffeine in their drinking water at concentrations equivalent to 0, 10 to 15 or 25 to 35 mg/kg/day of caffeine 7 days a week. after a period of adaptation to caffeine these monkeys were mated with untreated males. reproducti ... | 1988 | 3385636 |
| neutral lipid transfer and lipolysis convert high molecular weight ldl from cholesterol-fed nonhuman primates towards normal: a molecular analysis. | in cynomolgus monkeys (macaca fascicularis) fed an atherogenic diet, large, cholesterol ester-rich ldl (mr greater than 3.5.10(6] are found at the same time that the plasma triacylglycerol levels are low. we studied whether the presence of higher concentrations of triacylglycerol-rich lipoproteins (vldl) during in vitro incubations would allows depletion from ldl of cholesterol ester and a decreased ldl molecular weight. three high mr ldl (mr = (3.7-4.8).10(6)), rich in cholesterol ester (50 +/- ... | 1988 | 3390458 |
| tubal embryo transfer in cynomolgus monkeys: effects of hyperstimulation and synchrony. | to date the main limitation of in-vitro fertilization-embryo transfer (ivf-et) programmes is that transcervical transfer of embryos results in a rate of low implantation. on the other hand, the technique of gamete intra-fallopian transfer (gift) does not contribute to information on oocyte fertilization rates, and the time of oocyte exposure to sperm may be limited. the development of ultrasonically guided follicular aspiration will allow transfer of embryos generated in vitro to the fallopian t ... | 1988 | 3392178 |
| immune responses of cynomolgus monkeys to phthalic anhydride. | four groups of four macaca fascicularis monkeys were administered 10 consecutive weekly subcutaneous injections of 2 mg aluminum hydroxide plus one of the following: 200 micrograms of phthalic anhydride (pa)-monkey serum albumin (pa-msa, group 1); 200 micrograms of pa dissolved in ethanol-saline (etoh-sal, group 2); 200 micrograms of msa (group 3); or etoh-sal alone (group 4). direct intracutaneous tests to pa-msa, pa-etoh-sal, msa, and etoh-sal were applied at biweekly intervals throughout the ... | 1988 | 3392367 |
| experimental ab interno sclerotomies using a pulsed-dye laser. | we studied the use of a short-pulse, flashlamp-pumped dye laser, emitting at 666 nm, to create ab interno sclerotomies in cynomolgus monkeys using a fiberoptic delivery system. because of the low optical absorption of the sclera in the visible portion of the spectrum, ablation of sclera by continuous wave lasers emitting in this region requires high energies and produces significant thermal damage to surrounding tissues. to enhance the optical absorption of sclera, methylene blue dye was applied ... | 1988 | 3393051 |
| chronic low-level lead exposure in monkeys does not affect simple reaction time. | simple visual reaction time was measured in a group of adult monkeys (macaca fascicularis) dosed continuously with lead from birth onward, and in matched controls. blood lead concentrations had been stable for 6 years at 33 micrograms/dl at the time of testing. the monkey was required to make contact with a stainless steel bar to initiate a trial, and release it at the onset of a visual cue. delays between one and 13 sec were interposed between the initiation of the trial and the onset of the cu ... | 1988 | 3393300 |
| schedule-controlled behavior in infant and juvenile monkeys exposed to lead from birth. | monkeys (macaca fascicularis) were dosed orally from birth with 0 or 2000 micrograms/kg/day of lead as lead acetate. blood lead concentrations of treated monkeys peaked at an average of 115 micrograms/dl by 100 days of age, and decreased to a steady state level of 33 micrograms/dl after withdrawal from infant formula at 270 days of age. no overt signs of toxicity were observed. beginning at 60 days of age, monkeys were tested on a fixed ratio (fr) schedule of reinforcement, followed by a fixed i ... | 1988 | 3393304 |
| transplacental passage of a progesterone antagonist in monkeys. | the progesterone antagonist ru 486 dramatically increases myometrial contractility of the pregnant uterus, making it a potential adjunctive therapy for labor induction or therapeutic pregnancy termination. sixteen female cynomolgus monkeys were studied during the second or third trimester of pregnancy. hysterotomies were performed with the animals under anesthesia, providing access to the intact placental vasculature. ru 486 (25 mg) was injected intravenously into the mothers. serial blood sampl ... | 1988 | 3394742 |
| [morphometrical study of physical growth in infant cynomolgus monkeys using multivariate analysis]. | we describe the relative growth in infant cynomolgus monkeys (macaca fascicularis). the multivariate analyses using the principal component analysis and multivariate allometric analysis were applied to biometrical data of laboratory-bred cynomolgus monkeys aged from birth to 12 weeks. all the animals had been bred and reared under uniform environmental conditions at tsukuba primate center for medical science, n. i. h., japan. as the result of the principal component analysis, the cumulative cont ... | 1988 | 3396631 |
| attenuation by naloxone of the pressor effects of angiotensin ii in conscious cynomolgus monkeys. | the effects of naloxone and morphine on mean arterial blood pressure (mbp) and heart rate (hr) responses to angiotensin ii (aii) were studied in conscious cynomolgus monkeys. graded doses of aii (0.3, 1 and 3 micrograms/min for 8-10 min) were infused i.v. 20 min apart, preceded by an i.v. injection of either naloxone (1, 3 or 10 mg/kg), morphine (0.3, 1 or 3 mg/kg) or saline. pretreatment with naloxone (10 mg/kg) attenuated the pressor response to aii (0.3 or 1 microgram/min) by 25-50% but did n ... | 1988 | 3398708 |
| pharmacokinetics of rolipram in the rhesus and cynomolgus monkeys, the rat and the rabbit. studies on species differences. | 1. the pharmacokinetics of rolipram were studied in rat, rabbit, rhesus monkey and cynomolgus monkey using 14c- or 3h-labelled rolipram and a radioimmunoassay for measurement of unchanged drug. 2. rolipram was rapidly and completely absorbed after oral doses of up to 50 mg/kg. bioavailability was 0.1% in rhesus monkey, 3.7% in cynomolgus monkey, 3.6% in rabbit, 35% in rat, and 75% in man. 3. rolipram was able to pass the blood-brain barrier achieving concentrations in brain twice those in plasma ... | 1988 | 3400274 |
| the responsiveness of neurons in the insular gustatory cortex of the macaque monkey is independent of hunger. | (1) in order to determine whether the responsiveness of neurons in the insular gustatory cortex is influenced by hunger, neuronal activity was analysed in it while macaque monkeys (macaca fascicularis) were fed to satiety. the responses of single neurons in the insular gustatory cortex to the protypical taste stimuli glucose, nacl, hcl and quinine hcl, and to fruit juice, were measured before, while, and after the monkey was fed to satiety with glucose or fruit juice. (2) while behavior turned f ... | 1988 | 3406148 |
| psoriatic plaques in macaca fascicularis. | an adult male cynomolgus monkey (macaca fascicularis) developed erythematous plaques with adherent white scales on the skin. microscopically, the epidermis had regular acanthosis with marked parakeratosis, focal absence of stratum granulosum, and spongiform pustules and munro-like microabscesses. these histologic findings were suggestive of psoriasis vulgaris. | 1988 | 3407098 |
| human uterine luminal fluid volumes and prolactin levels in normal menstrual cycles. | human uterine luminal fluid has not been well characterized. prolactin is produced in vitro by decidualized human endometrium and is secreted in vivo into the uterine luminal fluid of cynomolgus monkeys. uterine luminal fluid prolactin has not been demonstrated in vivo in human beings. to study cyclic uterine luminal fluid volumes and prolactin levels, uterine luminal fluid was aspirated 8 to 13 times each during a single menstrual cycle in six ovulatory women. no anesthesia was used. seventy of ... | 1988 | 3407703 |
| positional behavior of long-tailed macaques (macaca fascicularis) in northern sumatra. | although the majority of extant primates are described as "quadrupedal," there is little information available from natural habitats on the locomotor and postural behavior of arboreal primate quadrupeds that are not specialized for leaping. to clarify varieties of quadrupedal movement, a quantitative field study of the positional behavior of a highly arboreal cercopithecine, macaca fascicularis, was conducted in northern sumatra. at least 70% of locomotion in travel, foraging, and feeding was mo ... | 1988 | 3407756 |
| persistently elevated sister chromatid exchanges in ethylene oxide-exposed primates: the role of a subpopulation of high frequency cells. | ethylene oxide (eto) is a potent dna-alkylating agent which has been shown to induce sister chromatid exchanges (sce) in the peripheral blood lymphocytes of exposed workers. to study further the persistence of eto-induced sce, we have examined lymphocytes from a group of cynomolgus monkeys exposed to eto in control, 50-ppm, and 100-ppm concentrations for 7 h/day, 5 days/week over the years 1979-1981. the data collected in 1987 were compared with those generated immediately prior to the cessation ... | 1988 | 3409233 |
| quantitative assessment of cynomolgus monkey trabecular cell phagocytosis and adsorption. | a simple double fluorescence technique is described which allows quantification of cynomolgus monkey trabecular cell phagocytosis and adsorption. within the first hour of exposure, significant adsorbance and minimal phagocytosis of polystyrene beads was observed. peak internalization occurred at six hours after increasing linearly at a rate of 20% of maximum per hour; adsorbance was constant and minimal. | 1988 | 3409712 |
| in vivo muscular force analysis during the isometric flexion on a monkey's elbow. | an experimental method has been developed to analyse muscular forces and torques in vivo during isometric flexion of the elbow in small monkeys (macaca fascicularis). a mini-transducer was built with a view to measure forces in situ, without cutting tendons. the positions of tendon insertions were measured on anatomical parts, then integrated in a series of calculations aiming of deducing the lever arms of forces to be included in a torque equilibrium relationship. muscle activity of the three m ... | 1988 | 3410860 |
| the responsiveness of neurones in the frontal opercular gustatory cortex of the macaque monkey is independent of hunger. | 1. in order to determine whether the responsiveness of neurones in the primary gustatory cortex is influenced by hunger, the activity of neurones in the gustatory cortex in the frontal operculum was recorded while macaque monkeys (macaca fascicularis) were fed to satiety. the responses of single neurones in the gustatory cortex to the prototypical taste stimuli glucose, nacl, hcl and quinine hydrochloride, and to fruit juice, were measured before, while, and after the monkey was fed to satiety w ... | 1988 | 3411507 |
| persistent sympathetic nervous system arousal associated with tethering in cynomolgus macaques. | the swivel-tether system has been used extensively in biomedical research involving nonhuman primates, yet there has been little or no investigation into potential adverse influences of this form of restraint on research results. in the study described here, a portable electrocardiographic telemetry system was used for continuous monitoring of the heart rate of 26 cynomolgus monkeys while: (a) pair-caged, 8 weeks prior to tethering; (b) singly-caged, tethered; (c) singly-caged, tethered, adminis ... | 1988 | 3411914 |
| ameloblastic odontoma in a cynomolgus monkey (macaca fascicularis). | an ameloblastic odontoma occurred in an adult cynomolgus monkey (macaca fascicularis). the neoplasm involved the upper left maxilla as a disfiguring, fleshy growth. the tissue and cellular changes were consistent with an ameloblastic odontoma which is rare in man, nonhuman primates (nhp), and other vertebrate animals. the monkey was one of 50 adult, single-caged housed cynomolgus monkeys. no additional clinical signs of disease were present. hematology and serum chemistries were within normal li ... | 1988 | 3411919 |
| surgical excision of an ameloblastic odontoma in a cynomolgus monkey (macaca fascicularis). | a surgical approach used for removal of maxillary tumors in humans was modified to excise a maxillary tumor in a cynomolgus monkey (macaca fascicularis). this is an effective technique for excising tumors, recovering fractured canine teeth, or other health problems of the maxillary region in macaca sp. the described approach limits facial disfigurement and enhances the probability of return to required function for future research utilization. this approach minimizes the extensive degree of post ... | 1988 | 3411920 |
| unexpected frostbite in cynomolgus macaques after a short exposure to snow. | 1988 | 3411923 | |
| influence of diet on (n-3) and (n-6) fatty acids in monkey erythrocytes. | cynomolgus monkeys were fed oils high in linoleic acid or with half of the linoleic acid replaced by either (n-3) linolenic acid or marine fatty acids. when the diet contained similar quantities of linoleic and (n-3) linolenic acid, erythrocyte fatty acids maintained a ratio of (n-6) to (n-3) fatty acids of approximately 2:4. fatty acids from menhaden oil enhanced the incorporation of eicosapentaenoic and docosahexaenoic acids into the monkey erythrocytes, the composition of which was not altere ... | 1988 | 3412131 |
| biosynthetic human growth hormone: subchronic toxicity studies in rats and monkeys. | biosynthetic human growth hormone was injected subcutaneously in rats for 90 days and in cynomolgus monkeys for 30 days. the daily doses were 0.5, 3.3 and 25 iu kg-1 (rats) and 0.3 and 15 iu kg-1 (monkeys). the growth hormone was tolerated well in both rats and monkeys. no drug related deaths occurred and all animals appeared to be normal and also behaved normally throughout the dosing period. increased body weight gain, increased food utilisation and increased organ weights were seen in the rat ... | 1988 | 3413036 |
| time-dependence of perfusion outflow facility in the cynomolgus monkey. | surgically virgin (n), aniridic (i), and ciliary muscle disinserted (d) cynomolgus monkey eyes had total outflow facility determined in vivo for 88-136 minutes by two-level constant pressure perfusion of the anterior chamber. in all three types of eyes, facility increased during the first hour but stabilized thereafter. average facility for the second half hour was 15% higher than for the first half hour in n and i eyes, and 10% higher in d eyes. altered iris muscle tone can therefore not explai ... | 1988 | 3416623 |
| [discriminant analyses for pregnancy-related changes in hematological and serum biochemical values in cynomolgus monkeys (macaca fascicularis)]. | hematological and serum biochemical data obtained from 45 non-pregnant and 142 pregnant cynomolgus monkeys (macaca fascicularis) were analyzed by discriminant analyses. all animals used had been reared under uniform environmental conditions at tsukuba primate center for medical science, n. i. h., japan. the examination items were as follows: red blood cell count(rbc), hematocrit value(ht), hemoglobin concentration(hb), mean corpuscular volume(mcv), white blood cell count(wbc), total protein (tp) ... | 1988 | 3416933 |
| dose-response relationship for translocation induction in spermatogonia of the crab-eating monkey (macaca fascicularis) by chronic gamma-ray-irradiation. | the induction of reciprocal translocations in spermatogonia of the crab-eating monkey (macaca fascicularis) by chronic gamma-irradiation (1.8 x 10(-5) gy/min, about 0.024 gy/22 h/day) was examined. the frequencies of translocation per cell were 0.15% at 0.3 gy, 0.27% at 1.0 gy and 0.33% at 1.5 gy. the dose-response relationship for translocation yield was a linear one with a regression coefficient (b) of 0.16 x 10(-2). when the slope (b) of the regression line was compared with that at a high do ... | 1988 | 3419451 |
| nd:yag laser posterior capsulotomy does not produce elevation of intraocular pressure in cynomolgus monkeys. | the mechanism of the intraocular pressure (iop) elevation commonly seen in patients following neodymium (nd):yag laser posterior capsulotomy is unclear. substance p, a potent polypeptide that is released into the eye after trigeminal nerve stimulation, may be the cause. in rabbits, topical application of nitrogen mustard causes a rise in iop which is blocked by capsaicin, a presumed substance p depletor. in the present study, six eyes of three cynomolgus monkeys underwent extracapsular lensectom ... | 1988 | 3419775 |
| recombinant vaccinia virus vaccine against the human melanoma antigen p97 for use in immunotherapy. | we have constructed a recombinant vaccinia virus, v-p97ny, which expresses the human melanoma-associated glycoprotein p97. immunization with v-p97ny could induce humoral and cell-mediated immunity to p97, including delayed-type hypersensitivity, in mice and in two of two monkeys (macaca fascicularis). the fact that an immune response was induced also in monkeys is important because normal cells from monkeys, but not from mice, express a low level of cross-reactive p97. mice immunized with v-p97n ... | 1988 | 3422478 |
| temporomandibular joint adaptations following maxillary osteotomy in adolescent monkeys. | the purpose of this study was to investigate the histologic appearance of temporomandibular joints of monkeys who had undergone total maxillary osteotomy. the specific aim of the study was to seek clues that might explain the inhibition in the mandibular growth 27 months following the surgery performed on adolescent monkeys. eighteen female adolescent macaca fascicularis monkeys were used. eight served as control and ten were experimental. all experimental animals underwent 3.0 to 5.0 mm superio ... | 1988 | 3422778 |
| low-level lifetime lead exposure produces behavioral toxicity (spatial discrimination reversal) in adult monkeys. | cynomolgus monkeys (macaca fascicularis) were dosed from birth with 0, 50, or 100 micrograms/kg/day of lead. this regimen resulted in blood lead concentrations of 3, 15, or 25 micrograms/dl, respectively, before withdrawal of infant formula at 200 days of age. blood lead concentration declined thereafter over the next 100 to 150 days to steady-state concentrations of 3, 11, or 13 micrograms/dl. at 9 to 10 years of age, these monkeys were tested on a series of spatial discrimination reversal prob ... | 1987 | 3424377 |
| effect of pregnancy on surgically induced endometriosis in cynomolgus monkeys. | there are few objective data to support the clinical impression that pregnancy exerts a beneficial effect on endometriosis. in this study, we examined the progression-regression of endometriosis in pregnant and nonpregnant monkeys. endometriosis was surgically induced in 16 monkeys and classified as minimal (n = 5), mild (n = 5), moderate (n = 4), or severe (n = 2). monkeys were mated and pregnancy occurred in three monkeys with minimal, three with mild, and one with moderate endometriosis. lapa ... | 1987 | 3425647 |
| insoluble uricase in liver peroxisomes of old world monkeys. | 1. subcellular localization form and properties of liver uricase of macaca fascicularis were examined. 2. uricase was present as the insoluble form in the peroxisomal core. 3. evidence was obtained to show that the peroxisomal core is uricase itself. 4. the number and mol. wts of the subunits of the enzyme were identical to those of rat liver uricase. 5. the same results were also obtained for liver uricase of macaca fuscata. | 1987 | 3427896 |
| the renal vascular system of the monkey: a gross anatomical description. | this study was conducted on two species of monkeys, macaca fascicularis and macaca mulatta, to describe their gross renal vascular morphology. after death, twelve monkeys were perfused with isotonic saline to flush their vascular systems. the monkeys were then perfused either with latex or methyl methacrylate, or both, one into the arterial and the other into the venous system. the results indicated that there were six to eight arterial segments in the monkey kidney, each supplied by a segmental ... | 1987 | 3429313 |
| sensory, motor and sympathetic neurons forming the common peroneal and tibial nerves in the macaque monkey (macaca fascicularis). | the motoneurons, dorsal root ganglion (drg) and sympathetic ganglion (sg) cells forming the common peroneal (cpn) and tibial (tn) nerves of young and semiadult monkeys (macaca fascicularis) were localised by the horseradish peroxidase method of tracing neuronal connections. the motoneurons forming the cpn occur in the l4-l6 segments, appearing as 1-3 groups and occupying the retroposterolateral (rpl), posterolateral (pl) and central (c) groups of motor nuclei. the motoneurons forming the tn occu ... | 1987 | 3429328 |
| scalp distribution of pattern visual evoked potentials in normal and hemianopic monkeys. | we examined the hemispheric distribution of the pattern visual evoked potential in 3 cynomolgus monkeys, before and after right optic tractotomy or left occipital lobectomy. the stimuli were vertical gratings of 4 spatial frequencies, presented using counterphase and on-off modulation at 1 and 8 hz. in the normal monkey, the amplitude and latency of the pveps elicited by 1 hz stimulation were similar across all electrode sites. while no differences were found in the phase of the pvep elicited by ... | 1987 | 3432382 |
| effects of vagotomy on the ultrastructure of the atrial myocardium in the monkey (macaca fascicularis). | the ultrastructure of the atrial myocardium in the monkey (macaca fascicularis) was studied after bilateral cervical vagotomy and survival times of 1, 3, 5, 7, 10, 21 and 28 days. during the first week after vagotomy, a few atrial cells showed a reduction in the sarcoplasm, crowding of the myofibrils, peripheral dispersion and reduced intercristal density of the mitochondria and increased sarcoplasmic reticulum and glycogen particles. in some profiles, there was increased electron density and gr ... | 1987 | 3434846 |
| effect of vagotomy and thoracic sympathectomy on responses of the monkey to water immersion. | cardiopulmonary stretch receptors have been implicated as part of a reflex mechanism linking changes in blood volume to changes in renal excretion. experiments were performed to determine whether total denervation of these receptors by combined cervical vagotomy and thoracic sympathectomy affects the renal responses of the monkey to head-out water immersion, a maneuver that translocates blood to the thorax and elicits an increase in renal salt and water excretion. macaca fascicularis monkeys fir ... | 1987 | 3436879 |
| spectral sensitivity of cones of the monkey macaca fascicularis. | 1. spectral sensitivities of cones in the retina of cynomolgus monkeys were determined by recording photocurrents from single outer segments with a suction electrode. 2. the amplitude and shape of the response to a flash depended upon the number of photons absorbed but not the wave-length, so that the 'principle of univariance' was obeyed. 3. spectra were obtained from five 'blue', twenty 'green', and sixteen 'red' cones. the wave-lengths of maximum sensitivity were approximately 430, 531 and 56 ... | 1987 | 3443931 |
| comparison of antigenicity of serum immunoglobulin g among human, cynomolgus monkey, african green monkey and squirrel monkey. | antigenicity of igg was compared among human, the cynomolgus monkey, the african green monkey and the squirrel monkey by the quantitative precipitation test using purified igg of and rabbit anti-igg serum to each species. clear cross-antigenicity was observed between the cynomolgus monkey and the african green monkey and less clear cross-antigenicity between human and the cynomolgus monkey or the african green monkey. the cross-antigenicity observed between the squirrel monkey and the other thre ... | 1987 | 3444086 |
| mitotic activity in monkey and rat leydig cells. | the testes of the monkey, macaca fascicularis, from birth to adulthood and of rats from puberty to adulthood were examined by both light and electron microscopy to estimate the mitotic activity of the leydig cells. in monkeys, mitotic activity was measurable only in neonates: 2.3% in leydig cells and 0.4% in fibroblast-like cells. from measurements of 3h-thymidine incorporation, mature leydig cells were labeled in neonates (2%) and adult animals (1%). the labeling indices were significantly incr ... | 1987 | 3448723 |
| preliminary electron microscopic observations on ependymal cells in the caudal segment of the filum terminale and the ampulla caudalis of macaca fascicularis and cercopithecus griseoviridis (primates, cercopithecidae). | in a previous paper, the concept of the terminal organ (to) of the subcommissural complex was forwarded. functionally this complex is a neuro (glio-) hemal organ which serves to discharge the reissner's secretory material into the systemic circulation. the to is characterized by structural specializations that make feasible the discharge and chemical decomposition of the secretory material stowed in the massa caudalis (mc). the to is probably not only the ampulla caudalis (ac); it may comprise e ... | 1987 | 3449414 |
| healing following meniscoplasty, eminectomy, and high condylectomy in the monkey temporomandibular joint. | the healing of meniscoplasty, eminectomy, and high condylectomy was studied in five macaca fascicularis monkeys. after five months of healing, no discontinuity defects were found in any of the plicated menisci, and all recontoured bone surfaces had new soft tissue linings. fibrous adhesions to the adjacent plicated meniscus developed in 62.5% of the recontoured bony surfaces. | 1986 | 3456437 |
| tissue reaction following application of extrusive and intrusive forces to teeth in adult monkeys. | intrusion has been regarded as a very controversial topic in the orthodontic literature. although it seems a logical way to handle deep overbite in adult patients who have elongated teeth, reports on iatrogenic damage have led to the suggestion of alternative methods. considering the disadvantages of these alternatives, it seems reasonable, however, to improve our knowledge of tissue reaction as related to intrusion. three macaca fascicularis monkeys were used for the experiment. by means of a s ... | 1986 | 3459360 |
| in-vivo bone strain as an indicator of masticatory bite force in macaca fascicularis. | the hypothesis that mandibular bone-strain patterns are a good indicator of molar bite-force patterns in m. fascicularis during mastication was tested by determining the relationship between mandibular bone-strain patterns and bite-force patterns during isometric biting. bone-strain patterns were determined using rosette strain gauges bonded to mandibular cortical bone below the roots of the m2 during isometric binding on a transducer along the m1-m2 region. the effects of rosette position on bo ... | 1986 | 3459403 |
| the effects of two temporary crown materials on the dental pulp of monkeys (macaca fascicularis). | 1986 | 3460966 | |
| distribution of substance p-like immunoreactive nerve fibers in temporomandibular joint soft tissues of monkey. | the distribution of substance p-immunoreactive and silver impregnated nerve fibers in the temporomandibular joint soft tissues of the macaca fascicularis monkey was investigated in frozen sections. the pattern of substance p-immunoreactive structures in the soft tissues and periosteum of the temporomandibular joint was compared with the distribution of silver impregnated nerve fibers within these tissues. presence of substance p-immunoreactive fibers was demonstrated in the temporomandibular joi ... | 1986 | 3461542 |
| extrusive mobility of teeth in adult monkeys (macaca fascicularis). | extrusive mobility of 15 teeth in 4 adult macaques was compared with intrusive mobility of the same teeth. the character of the load displacement and recovery records was similar; the qualitative response to repeated 4 n thrusts, 4 n loads sustained for 30 s and residual loading with 50, 30 and 10 mn, was the same whether the force was applied in an intrusive or extrusive direction. fast and slow loading rates (100 and 1 ns-1) both caused greater intrusion than extrusion at 4 n (p less than 0.00 ... | 1986 | 3463263 |
| long-term timolol and epinephrine in monkeys. i. functional morphology of the ciliary processes. | cynomolgus monkeys were treated twice daily in one eye with timolol 180 micrograms for 2.7, 6.0, or 7.4 months (2 monkeys for each period) or epinephrine 540-600 micrograms for 6.7 months (2 monkeys). some ciliary processes in both eyes of all timolol-treated monkeys exhibited light and electron microscopic changes consistent with decreased secretion: narrowed stromal vessels with few fenestrations surrounded by a thickened fibre sheath; thickened pe basement membrane; few pe and npe basolateral ... | 1986 | 3467494 |
| long-term timolol and epinephrine in monkeys. ii. morphological alterations in trabecular meshwork and ciliary muscle. | cynomolgus monkeys were treated twice daily in one eye with timolol 180 micrograms or epinephrine 540-600 micrograms for several months. in some regions, timolol induced degeneration of trabecular meshwork endothelium and destruction of the central connective tissue core of the lamellae, leaving a rarified meshwork. in some areas, the lamellae and operculum coalesced and appeared 'glued' together. increased numbers of subopercular cells were present. in other areas the muscle was pulled inwardly ... | 1986 | 3467495 |
| the influence of diet on the growth of streptococcal bacteria on the molar teeth of monkeys (macaca fascicularis). | the rates of regrowth of bacteria in developmental grooves on these teeth were determined. plaque was removed from palatal grooves up to 96 h after cleaning and the number of bacteria and of individual streptococcal species were determined; streptococcus sanguis, streptococcus mutans and streptococcus mitior were the major ones. in monkeys fed one of three different diets, the numbers of each species reached stable levels 18-24 h after tooth cleaning. the median doubling times of the streptococc ... | 1986 | 3467667 |
| effects of intracamerally infused prostaglandins on outflow facility in cynomolgus monkey eyes with intact or retrodisplaced ciliary muscle. | cynomolgus monkeys with intact or surgically retrodisplaced ciliary muscle received intracameral infusion of prostaglandins (pg) e1, e2, and f2 alpha in doses yielding initial anterior chamber concentrations ranging from approximately 0.2 microm to approximately 0.2 mm. the effects on total outflow facility, as determined by two-level constant pressure perfusion, within the first 40 min after pg infusion were at most sporadic and minimal, and pgf2 alpha had no effect at any of the dosages given. ... | 1986 | 3467979 |
| facial growth subsequent to le fort i osteotomies in adolescent monkeys. | the study goal was to assess qualitatively and quantitatively the craniofacial adaptations following total maxillary osteotomy with and without mandibular autorotation. six adolescent female macaca fascicularis monkeys were randomly divided into two surgical groups, and eight others served control. prior to surgery, metallic implants were inserted in the anterior part of the cranial base, on opposite sides of craniofacial sutures, and in multiple sites of the maxilla and mandible. group i animal ... | 1987 | 3468214 |
| multiple dosing of prostaglandin f2 alpha or epinephrine on cynomolgus monkey eyes. i. aqueous humor dynamics. | after obtaining baseline intraocular pressure (iop) measurements for 1 week, prostaglandin (pg) f2 alpha (250 micrograms in 50 microliters saline) or epinephrine 2% solution (50 microliters) was topically applied twice daily for 2 weeks to one eye of six cynomolgus monkeys for each agent tested. contralateral control eyes received their respective vehicles. pgf2 alpha significantly reduced iop beginning 2 to 3 hr after the first dose, persisting thereafter. a significant (p less than 0.05) hypot ... | 1987 | 3470269 |
| multiple dosing of prostaglandin f2 alpha or epinephrine on cynomolgus monkey eyes. ii. slit-lamp biomicroscopy, aqueous humor analysis, and fluorescein angiography. | prostaglandin (pg) f2 alpha (250 micrograms in 50 microliters saline) or epinephrine 2% solution (50 microliters) was topically applied twice daily for 2 weeks to one eye of six cynomolgus monkeys for each agent. contralateral control eyes received their respective vehicles. a trace aqueous humor flare response occurred in some pgf2 alpha-treated eyes, which reached significance (p less than 0.05) only when observed 4 hr after the first or seventh dose. no significant anterior chamber cellular r ... | 1987 | 3473055 |
| mandibular growth following le fort i osteotomy in adolescent monkeys. | le fort i osteotomy with anterior and superior repositioning of the maxilla was performed on adolescent macaca fascicularis monkeys to study its effect on the subsequent growth and remodeling changes of the mandible. six adolescent macaca fascicularis monkeys were randomly divided into two surgical groups and eight others served as controls. group i animals underwent a le fort i advancement and group ii animals experienced a le fort i advancement and impaction. all monkeys received tantalum impl ... | 1987 | 3473198 |
| evaluation of an intraoral controlled release delivery system for fluoride in primates. | an intraoral delivery system designed to release 0.5 mg of fluoride per day was evaluated in short-term studies in primates. this fluoride-releasing device, bonded to the buccal surface of the maxillary right central incisor of each of six monkeys (macaca fascicularis), produced marked elevations in saliva and plaque fluoride concentrations without increases in serum fluoride concentrations. no changes were observed in the plaque and gingival scores or the populations of various species of plaqu ... | 1987 | 3474094 |
| minor salivary gland duct-associated lymphoid tissue (dalt) in monkeys changes with age. | the duct-associated lymphoid tissue (dalt) of minor salivary glands (msg) is accessible to oral antigens by retrograde passage. dalt responds immunologically to such purely local and duct-derived antigenic stimuli. this study addressed the question as to whether dalt, like other mammalian lymphoid tissues, would change with age. labial and buccal mucosae of eight macaca fascicularis animals of known age were processed for light microscopy by epon embedding. sections of approximately 1-2 microns ... | 1987 | 3476564 |
| molecular basis of salivary proline-rich protein and peptide synthesis: cell-free translations and processing of human and macaque statherin mrnas and partial amino acid sequence of their signal peptides. | acidic proline-rich phosphoproteins and phosphopeptides are abundant components of parotid and submandibular salivary secretions in man and in the subhuman primate, macaca fascicularis. the major acidic proline-rich proteins and the proline-rich phosphopeptide, statherin, of man and macaques have been shown to be potent inhibitors of calcium phosphate precipitation and are thought to function in the oral environment by maintaining saliva supersaturated with respect to calcium phosphate salts. li ... | 1987 | 3476566 |
| pilocarpine antagonizes prostaglandin f2 alpha-induced ocular hypotension in monkeys. evidence for enhancement of uveoscleral outflow by prostaglandin f2 alpha. | twice daily topical application of 50 micrograms of prostaglandin f2 alpha tromethamine to cynomolgus monkey eyes produced significant ocular hypotension lasting at least six hours, with the intraocular pressure (iop) falling between 35% and 50%, ie, to about 8 to 10 mm hg, following the seventh dose. a single topical application of 1 mg of pilocarpine hydrochloride produced a much smaller iop reduction and strong, probably maximal accommodation, both of which lasted at least eight hours. when p ... | 1987 | 3477218 |
| growth direction in the mandibular condyle of pre-pubertal and pubertal monkeys (macaca fascicularis) studied by morphometry and radioautography. | eight male monkeys with prepubertal or pubertal skeletal maturity were used to assess age-related changes in anterior-posterior gradients of parameters which characterize growth velocity. the animals received single intravenous doses of 1 mci/kg body weight of [3h]-proline at 24 h, and of 0.5 mci/kg body weight [3h]-thymidine, 3 h before death. four perichondral and chondral layers, and the subchondral zone of erosion of each condyle, were analysed morphometrically and radioautographically at 12 ... | 1987 | 3478026 |
| duct-associated lymphoid tissue (dalt) of minor salivary glands in the monkey, cercopithecus aethiops. | this study reports on the characteristic topographical distribution of dalt within the labial and buccal mucosae of cercopithecus aethiops. a total of 140 labial and 24 buccal mucosal tissue blocks, originating from 11 animals, were examined light microscopically. all animals revealed dalt in varying numbers of epon blocks. in c. aethiops, dalt is a comparatively rare phenomenon and appears to develop almost exclusively around msg duct orifices and along the course of main ducts traversing the s ... | 1987 | 3478033 |
| the effect of excision of the root apex on the intrusive mobility of anterior teeth in adult monkeys (macaca fascicularis). | intrusive tooth mobility was recorded on anterior teeth in four adult male animals by linear variable-differential transformers. reflection of the labial mucosa caused a significant increase in mobility at 4 n when the loading rate was slow (1 n s-1) but not when fast (100 n s-1). no significant additional increase in mobility was recorded after the apices were removed from eight incisors and canines. a further study on five incisors was made in which the displacement at 4 n load was noted half ... | 1987 | 3478035 |
| effects of topical pgf2 alpha on aqueous humor dynamics in cynomolgus monkeys. | single topical applications of prostaglandin f2 alpha (pgf2 alpha) tromethamine salt to living cynomolgus monkey eyes reduced intraocular pressure (iop). twice daily topical application was far more effective, so that after the 7th 50 micrograms or 100 micrograms dose on day 4, iop fell 40-50%, to 8-10 mm hg. following twice daily application of 50 or 100 micrograms for greater than 3 days: (1) no increase in total outflow facility could be demonstrated by 2-level constant pressure perfusion or ... | 1987 | 3478175 |
| a cinephotographic study of the role of the canine in limiting lateral jaw movement in macaca fascicularis. | three specimens of macaca fascicularis were examined to test the hypothesis that the canines do not restrict lateral masticatory movements in these animals. the animals were filmed while chewing freely before, shortly after, and seven weeks after canine removal. facial markers, viewed from the lateral plane, allowed for computer tracings of all mandibular movements. the maximal lateral movement of the mandible was assessed for each chewing cycle, and means were calculated for each test condition ... | 1986 | 3478387 |
| biochemical changes in periodontal ligament ground substance associated with short-term intrusive loadings in adult monkeys (macaca fascicularis). | proteoglycan-like fractions (pg) were isolated from the ligaments of teeth undergoing various degrees of intrusive loadings. the pg were characterized by their molecular-size profiles on sepharose 4b, the presence of uronic acid in the separated fractions and by the electrophoretic detection of constituent glycosaminoglycans including heparan sulphate, hyaluronic acid, dermatan sulphate and chondroitin-4-sulphate. the high molecular-weight fraction, peak i (estimated minimum size, 2 x 10(6) dalt ... | 1987 | 3479096 |
| jaw movements and patterns of mandibular bone strain during mastication in the monkey macaca fascicularis. | small amalgam fillings were placed in maxillary and mandibular second molar and canine teeth for cine-radiographic analysis. the rosette strain gauges were bonded bilaterally to mandibular cortical bone below the second or third molars. the monkeys were placed in a restraining chair that did not restrict normal head, neck or jaw movements; they were fed various foods and the bone-strain data recorded. simultaneous jaw movements were recorded with cine-radiographic apparatus synchronized with the ... | 1986 | 3479960 |
| a comparison of short-term periapical responses to hand and ultrasonic file overextension during root canal instrumentation in the macaca fascicularis monkey. | 1987 | 3481807 | |
| immunohistochemical study of the local inflammatory response to chlamydial ocular infection. | immunohistochemical staining of conjunctival biopsies from cynomolgus monkeys (macaca fascicularis) was performed after they received a single primary ocular infection, a single secondary challenge infection, or repeated ocular inoculations with chlamydia trachomatis. t cells of the suppressor/cytotoxic (okt8f) phenotype predominated regardless of the infection protocol, and perifollicular t lymphocytes of both the suppressor/cytotoxic and helper (okt4a) phenotypes appeared in large numbers duri ... | 1986 | 3484473 |
| immune mechanisms in chlamydial eye infection. development of t suppressor cells. | in vitro proliferation assays of whole peripheral blood mononuclear leukocytes (pbml) and pbml depleted of suppressor t cells were performed in cynomolgus monkeys after they had received one, two, or repeated ocular inoculations with chlamydia trachomatis. whole pbml responded only weakly to chlamydial antigen, and responses to concanavalin a were depressed for 12 wk following ocular infection. depletion of the suppressor t cell population did not result in increased chlamydia-specific prolifera ... | 1986 | 3485615 |
| assay of primate seminiferous tubule androgen receptors using [3h]mibolerone. | the synthetic radiolabelled androgen mibolerone (7 alpha, 17 alpha-dimethyl-19-nortestosterone) was used to characterize androgen receptor binding in the seminiferous tubules from cynomolgus monkey testis. mibolerone binding was of high affinity (kd = 0.6-5.4 nm) and limited capacity (37-50 fmol/mg protein), and was androgen specific. sucrose density gradient centrifugation using a vertical tube rotor permitted the identification of a 9s molybdate-stabilized receptor under low salt conditions. t ... | 1986 | 3487680 |
| the catecholamine uptake blocker nomifensine protects against mptp-induced parkinsonism in monkeys. | administration of mptp (1-methyl-1,2,3,6-tetrahydropyridine) to macaca fascicularis monkeys produced severe parkinsonism (hypokinesia, tremor, rigidity, aphagia, adipsia) and more than 90% loss of nigral dopamine neurons, striatal dopamine content and striatal 3h-mazindol binding. treatment with the catecholamine uptake blocker nomifensine counteracted the behavioral, histological and neurochemical effects induced by mptp. for obtaining best protection, nomifensine had to be administered for wee ... | 1986 | 3488228 |