Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| arboviral diseases and malaria in australia, 2011-12: annual report of the national arbovirus and malaria advisory committee. | the national notifiable diseases surveillance system received notifications for 7,875 cases of disease transmitted by mosquitoes during the 2011-12 season (1 july 2011 to 30 june 2012). the alphaviruses barmah forest virus and ross river virus accounted for 6,036 (77%) of these. there were 18 notifications of dengue virus infection acquired in australia and 1,390 cases that were acquired overseas, while for 38 cases, the place of acquisition was unknown. imported cases of dengue in australia wer ... | 2014 | 25222207 |
| vector competence of aedes aegypti populations from kilifi and nairobi for dengue 2 virus and the influence of temperature. | susceptibility of ae. aegypti mosquito to dengue virus (denv) varies geographically and can be influenced by climatic factors such as temperature, which affect the incidence, seasonality and distribution of vector-borne diseases. the first outbreak of dengue fever (df) in kenya occured in 1982 in the coastal towns of malindi and kilifi. unlike nairobi where no active dengue transmission has been reported, df is currently re-emerging at the coast causing major outbreaks. this study investigated t ... | 2014 | 25223760 |
| dengue in children. | dengue is a mosquito-borne viral disease of expanding geographical range and increasing incidence. the vast majority of dengue cases are children less than 15 years of age. dengue causes a spectrum of illness from mild fever to severe disease with plasma leakage and shock. infants and children with secondary heterologous dengue infections are most at risk for severe dengue disease. laboratory diagnosis of dengue can be established within five days of disease onset by direct detection of viral co ... | 2014 | 25225163 |
| synthesis of silver nanoparticles from azadirachta indica--a most effective method for mosquito control. | mosquitoes transmit major communicable diseases such as dengue, malaria, filariasis, japanese encephalitis, chikungunya, and so on. vector control is important in epidemic disease situations as there is an urgent need to develop new and improved mosquito control methods that are economical and effective yet safe for non-targeted organisms. in the present study, silver nanoparticles (agnps) were synthesized from the aqueous leaf extract of neem plant (azadirachta indica), and their effects on mos ... | 2015 | 25226837 |
| laboratory evaluation of the development of aedes aegypti in two seasons: influence of different places and different densities. | aedes aegypti is an important vector in brazil being the main vector of the dengue-fever. this paper employs survival curves to describe the time in days from larvae to adult forms of aedes aegypti raised, individually and collectively, and compares it during winter and spring when positioned inside and outside a laboratory. the study was conducted in são vicente, a coastal city in southeastern brazil. the lowest water temperature in winter and in spring was 20 °c and the highest was 26 °c in sp ... | 0 | 25229215 |
| multiobjective genetic algorithm applied to dengue control. | dengue fever is an infectious disease caused by a virus of the flaviridae family and transmitted to the person by a mosquito of the genus aedes aegypti. this disease has been a global public health problem because a single mosquito can infect up to 300 people and between 50 and 100 million people are infected annually on all continents. thus, dengue fever is currently a subject of research, whether in the search for vaccines and treatments for the disease or efficient and economical forms of mos ... | 2014 | 25230238 |
| genetic diversity of brazilian aedes aegypti: patterns following an eradication program. | aedes aegypti is the most important vector of dengue fever in brazil, where severe epidemics have recently taken place. ae. aegypti in brazil was the subject of an intense eradication program in the 1940s and 50s to control yellow fever. brazil was the largest country declared free of this mosquito by the pan-american health organization in 1958. soon after relaxation of this program, ae. aegypti reappeared in this country, and by the early 1980s dengue fever had been reported. the aim of this s ... | 2014 | 25233218 |
| bionomic response of aedes aegypti to two future climate change scenarios in far north queensland, australia: implications for dengue outbreaks. | dengue viruses are transmitted by anthropophilic mosquitoes and infect approximately 50 million humans annually. to investigate impacts of future climate change on dengue virus transmission, we investigated bionomics of the mosquito vector, aedes aegypti. | 2014 | 25240382 |
| chikungunya in the caribbean: an epidemic in the making. | chikungunya is a mosquito-borne virus that has shown increased prevalence in the caribbean since october 2013. there have been several outbreaks throughout asian and african countries over the past few decades with global travel and tourism having a major impact on the further spread of this disease. improved policies and practices for preventative measures and epidemiological surveillance must be implemented to prevent the continued transmission of chikungunya. | 2014 | 25245516 |
| field evaluation of natural human odours and the biogent-synthetic lure in trapping aedes aegypti, vector of dengue and chikungunya viruses in kenya. | methods currently used in sampling adult aedes aegypti, the main vector of dengue and chikungunya viruses are limited for effective surveillance of the vector and accurate determination of the extent of virus transmission during outbreaks and inter - epidemic periods. here, we document the use of natural human skin odours in baited traps to improve sampling of adult ae. aegypti in two different endemic areas of chikungunya and dengue in kenya - kilifi and busia counties. the chemistry of the vol ... | 2014 | 25246030 |
| how dengue vector aedes albopictus (diptera: culicidae) survive during the dry season in dhaka city, bangladesh? | in 2000, a dengue outbreak occurred in bangladesh that included dhaka city. both dengue vectors, aedes aegypti and ae. albopictus are present in bangladesh. aedes aegypti mosquitoes mainly breed in and around houses and ae. albopictus is an outside breeder. there are many old trees throughout dhaka city in different parks, streets and the university campus which may have holes that can contribute as potential breeding habitat for the dengue vector. therefore, a survey was conducted to investigat ... | 2014 | 25253210 |
| characteristics of a dengue outbreak in a remote pacific island chain--republic of the marshall islands, 2011-2012. | dengue is a potentially fatal acute febrile illness caused by four mosquito-transmitted dengue viruses (denv-1-4). although dengue outbreaks regularly occur in many regions of the pacific, little is known about dengue in the republic of the marshall islands (rmi). to better understand dengue in rmi, we investigated an explosive outbreak that began in october 2011. suspected cases were reported to the ministry of health, serum specimens were tested with a dengue rapid diagnostic test (rdt), and c ... | 2014 | 25268134 |
| vector competence in west african aedes aegypti is flavivirus species and genotype dependent. | vector competence of aedes aegypti mosquitoes is a quantitative genetic trait that varies among geographic locations and among different flavivirus species and genotypes within species. the subspecies ae. aegypti formosus, found mostly in sub-saharan africa, is considered to be refractory to both dengue (denv) and yellow fever viruses (yfv) compared to the more globally distributed ae. aegypti aegypti. within senegal, vector competence varies with collection site and denv-2 viral isolate, but kn ... | 2014 | 25275366 |
| in silico models for predicting vector control chemicals targeting aedes aegypti. | human arboviral diseases have emerged or re-emerged in numerous countries worldwide due to a number of factors including the lack of progress in vaccine development, lack of drugs, insecticide resistance in mosquitoes, climate changes, societal behaviours, and economical constraints. thus, aedes aegypti is the main vector of the yellow fever and dengue fever flaviviruses and is also responsible for several recent outbreaks of the chikungunya alphavirus. as for the other mosquito species, the a. ... | 2014 | 25275884 |
| dengue vectors, human activity, and dengue virus transmission potential in the lower rio grande valley, texas, united states. | dengue virus is an emerging disease of concern in the americas. recent outbreaks in florida highlight the potential for the virus to return to the united states. the lower rio grande valley region of texas directly borders mexico, and has experienced dengue transmission in the past concurrent with outbreaks in mexico along the border region. we examined the potential for dengue virus transmission by examining the vectors in the region, as well as assessing human behavior. we further hypothesized ... | 2014 | 25276932 |
| larvicidal, repellent, and irritant potential of the seed-derived essential oil of apium graveolens against dengue vector, aedes aegypti l. (diptera: culicidae). | aedes aegypti l. is one of the primary disease vectors spreading various dreadful diseases throughout the world, specifically over tropics and subtropics. keeping in view the adverse effects of chemical insecticides-based intervention measures, the eco-friendly and bio-degradable essential oil extracted from the seeds of celery, apium graveolens were investigated for its efficacy against ae. aegypti. larvicidal bioassay carried out with the seed oil against early fourth instars of ae. aegypti ca ... | 2014 | 25279371 |
| evaluation of plant-mediated synthesized silver nanoparticles against vector mosquitoes. | diseases transmitted by blood-feeding mosquitoes, such as dengue fever, dengue hemorrhagic fever, japanese encephalitis, malaria, and filariasis, are increasing in prevalence, particularly in tropical and subtropical zones. to control mosquitoes and mosquito-borne diseases, which have worldwide health and economic impacts, synthetic insecticide-based interventions are still necessary, particularly in situations of epidemic outbreak and sudden increases of adult mosquitoes. green nanoparticle syn ... | 2014 | 25300419 |
| insecticidal and genotoxic potential of two semi-synthetic derivatives of dillapiole for the control of aedes (stegomyia) aegypti (diptera: culicidae). | the effects of two semi-synthetic dillapiole derivatives, ethyl-ether dillapiole and n-butyl ether dillapiole, on eggs and larvae of aedes aegypti were studied in view of the need for expansion and renovation of strategic action to control this mosquito - the vector of dengue virus -, which currently shows a high resistance to chemical insecticides. eggs and third-instar larvae of a. aegypti that had been exposed to different concentrations of these two compounds showed toxicity and susceptibili ... | 2014 | 25308546 |
| experimental inoculation of artibeus jamaicensis bats with dengue virus serotypes 1 or 4 showed no evidence of sustained replication. | dengue is the most important mosquito-borne viral disease to humans. bats are potential reservoirs for flaviviruses, including dengue virus (denv). in this work, artibeus jamaicensis bats were inoculated with two serotypes of denv using different routes. for experimental inoculations (ei) 1 and 2, bats were inoculated subcutaneously or intraperitoneally with denv-4; for ei-3 bats were inoculated intraperitoneally with denv-1. mock inoculated bats were kept as controls. in ei-4, bats were bitten ... | 2014 | 25311698 |
| larvicidal activity of persea americana mill. against aedes aegypti. | to evaluate the toxicity of the ethanol and hexane extracts of the different parts of persea americana mill. (p. americana) toward third and fourth instars larvae of aedes aegypti (ae. aegypti) and to characterize the ethanol extract by qualitative phytochemical analysis. | 2014 | 25312114 |
| social sustainability of mesocyclops biological control for dengue in south vietnam. | copepod mesocyclops as biological control agents for dengue was previously proven to be effective and sustainable in the northern and central provinces of vietnam. we aim to study social sustainability of mesocyclops intervention in south vietnam. both quantitative and qualitative approaches were used. an entomological survey was carried out in 100 random households of chanh an commune, vinh long province. aedes larval indices and mesocyclops prevalence were compared with historical pre- and pos ... | 2015 | 25312335 |
| effective surveillance of vector dynamics of aedes aegypti in a hospital setting in cuiabá, mato grosso, brazil. | hospitals are important for vector control of endemic diseases. | 2014 | 25313617 |
| effects of croton rhamnifolioides essential oil on aedes aegypti oviposition, larval toxicity and trypsin activity. | although numerous reports are available concerning the larvicidal potential of essential oils, very few investigations have focused on their mechanisms of action. in the present study, we have investigated the chemical composition of the leaf oil of croton rhamnifolioides during storage and its effects on oviposition and survival of larvae of the dengue fever mosquito aedes aegypti. in addition, we have established a possible mechanism of action for the larvicidal activity of the essential oil. ... | 2014 | 25317582 |
| dengue outbreaks in divinopolis, south-eastern brazil and the geographic and climatic distribution of aedes albopictus and aedes aegypti in 2011-2012. | to entomologically monitor aedes spp. and correlate the presence of these vectors with the recent epidemic of dengue in divinopolis, minas gerais state, brazil. | 2015 | 25328988 |
| qtl mapping of genome regions controlling temephos resistance in larvae of the mosquito aedes aegypti. | the mosquito aedes aegypti is the principal vector of dengue and yellow fever flaviviruses. temephos is an organophosphate insecticide used globally to suppress ae. aegypti larval populations but resistance has evolved in many locations. | 2014 | 25330200 |
| evaluation of aadop2 receptor antagonists reveals antidepressants and antipsychotics as novel lead molecules for control of the yellow fever mosquito, aedes aegypti. | the yellow fever mosquito, aedes aegypti, vectors disease-causing agents that adversely affect human health, most notably the viruses causing dengue and yellow fever. the efficacy of current mosquito control programs is challenged by the emergence of insecticide-resistant mosquito populations, suggesting an urgent need for the development of chemical insecticides with new mechanisms of action. one recently identified potential insecticide target is the a. aegypti d1-like dopamine receptor, aadop ... | 2014 | 25332454 |
| chromobacterium csp_p reduces malaria and dengue infection in vector mosquitoes and has entomopathogenic and in vitro anti-pathogen activities. | plasmodium and dengue virus, the causative agents of the two most devastating vector-borne diseases, malaria and dengue, are transmitted by the two most important mosquito vectors, anopheles gambiae and aedes aegypti, respectively. insect-bacteria associations have been shown to influence vector competence for human pathogens through multi-faceted actions that include the elicitation of the insect immune system, pathogen sequestration by microbes, and bacteria-produced anti-pathogenic factors. t ... | 2014 | 25340821 |
| gene expression patterns and sequence polymorphisms associated with mosquito resistance to bacillus thuringiensis israelensis toxins. | despite the intensive use of bacillus thuringiensis israelensis (bti) toxins for mosquito control, little is known about the long term effect of exposure to this cocktail of toxins on target mosquito populations. in contrast to the many cases of resistance to bacillus thuringiensis cry toxins observed in other insects, there is no evidence so far for bti resistance evolution in field mosquito populations. high fitness costs measured in a bti selected mosquito laboratory strain suggest that evolv ... | 2014 | 25341495 |
| dengue virus infections among haitian and expatriate non-governmental organization workers--léogane and port-au-prince, haiti, 2012. | in october 2012, the haitian ministry of health and the us cdc were notified of 25 recent dengue cases, confirmed by rapid diagnostic tests (rdts), among non-governmental organization (ngo) workers. we conducted a serosurvey among ngo workers in léogane and port-au-prince to determine the extent of and risk factors for dengue virus infection. of the total 776 staff from targeted ngos in léogane and port-au-prince, 173 (22%; 52 expatriates and 121 haitians) participated. anti-dengue virus (denv) ... | 2014 | 25356592 |
| novel dna extraction assay for molecular identification of aedes spp eggs. | aedes aegypti and a. albopictus represent the two most important species of mosquitoes in relation to dengue virus transmission both in the americas and asia. however, the study of theses species generally requires the establishment of a colony for the larvae to hatch, or waiting for the adult development to perform its taxonomic classification, which is time consuming. thus, the establishment of new methods aimed at obtaining dna directly from the mosquito eggs is relevant. accordingly, we comp ... | 2014 | 25366769 |
| larvicidal efficacy of different plant parts of railway creeper, ipomoea cairica extract against dengue vector mosquitoes, aedes albopictus (diptera: culicidae) and aedes aegypti (diptera: culicidae). | natural insecticides from plant origin against mosquito vectors have been the main concern for research due to their high level of eco-safety. control of mosquitoes in their larval stages are an ideal method since aedes larvae are aquatic, thus it is easier to deal with them in this habitat. the present study was specifically conducted to explore the larvicidal efficacy of different plant parts of ipomoea cairica (l.) or railway creeper crude extract obtained using two different solvents; methan ... | 2014 | 25368088 |
| a social-ecological analysis of community perceptions of dengue fever and aedes aegypti in machala, ecuador. | the growing burden of dengue fever and the lack of a vaccine or specific medical treatment have increased the urgency of the public health sector to identify alternative management strategies. a prevailing trend in latin america has been a shift towards decentralized vector control programs with integrated management strategies, requiring significant intersectoral coordination, community engagement, and knowledge of the local social-ecological system (ses). community perceptions and responses ar ... | 2014 | 25370883 |
| surveillance for dengue and dengue-associated neurologic syndromes in the united states. | autochthonous dengue virus transmission has occurred in the continental united states with increased frequency during the last decade; the principal vector, aedes aegypti, has expanded its geographic distribution in the southern united states. dengue, a potentially fatal arboviral disease, is underreported, and us clinicians encountering patients with acute febrile illness consistent with dengue are likely to not be fully familiar with dengue diagnosis and management. recently, investigators sug ... | 2014 | 25371183 |
| local evolution of pyrethroid resistance offsets gene flow among aedes aegypti collections in yucatan state, mexico. | the mosquito aedes aegypti is the major vector of the four serotypes of dengue virus (denv1-4). previous studies have shown that ae. aegypti in mexico have a high effective migration rate and that gene flow occurs among populations that are up to 150 km apart. since 2000, pyrethroids have been widely used for suppression of ae. aegypti in cities in mexico. in yucatan state in particular, pyrethroids have been applied in and around dengue case households creating an opportunity for local selectio ... | 2014 | 25371186 |
| an unusual ocular emergency in severe dengue. | dengue, one of the most common mosquito-borne flavivirus diseases affecting humans, is spread by the aedes aegypti mosquito. most people infected with dengue virus are asymptomatic or only have mild symptoms such as an uncomplicated fever; few have more severe features, while in a small proportion it is life-threatening. severe dengue is defined as that associated with severe bleeding, severe organ dysfunction, or severe plasma leakage. ophthalmic manifestations can involve both the anterior and ... | 0 | 25371643 |
| aedes mosquito species in western saudi arabia. | the aedes meigen (diptera: culicidae) mosquito species populations in the western region of saudi arabia, especially in and around jeddah, are increasing, therefore increasing susceptibility of humans to the dengue virus. an extensive survey was carried out for one year, and four species were identified with the help of different pictorial keys available. the identification was based on morphological characteristics of adult female aedes mosquitoes. | 2014 | 25373216 |
| discovery and characterization of a potent and selective inhibitor of aedes aegypti inward rectifier potassium channels. | vector-borne diseases such as dengue fever and malaria, which are transmitted by infected female mosquitoes, affect nearly half of the world's population. the emergence of insecticide-resistant mosquito populations is reducing the effectiveness of conventional insecticides and threatening current vector control strategies, which has created an urgent need to identify new molecular targets against which novel classes of insecticides can be developed. we previously demonstrated that small molecule ... | 2014 | 25375326 |
| challenges encountered using standard vector control measures for dengue in boa vista, brazil. | in 2010, dengue virus (denv) serotype-4 was detected during a dengue outbreak in the amazonian city of boa vista. at that time brazil was already endemic for denv-1, denv-2 and denv-3. this was the first time denv-4 was observed in the country after it was initially detected and eliminated in 1981. | 2014 | 25378760 |
| oviposition deterring and oviciding potentials of ipomoea cairica l. leaf extract against dengue vectors. | bioprospecting of plant-based insecticides for vector control has become an area of interest within the last two decades. due to drawbacks of chemical insecticides, phytochemicals of plant origin with mosquito control potential are being utilized as alternative sources in integrated vector control. in this regard, the present study aimed to investigate oviposition deterring and oviciding potentials of ipomoea cairica (l.) (family: convolvulaceae) crude leaf extract against dengue vectors, aedes ... | 2014 | 25382472 |
| evolution of mosquito preference for humans linked to an odorant receptor. | female mosquitoes are major vectors of human disease and the most dangerous are those that preferentially bite humans. a 'domestic' form of the mosquito aedes aegypti has evolved to specialize in biting humans and is the main worldwide vector of dengue, yellow fever, and chikungunya viruses. the domestic form coexists with an ancestral, 'forest' form that prefers to bite non-human animals and is found along the coast of kenya. we collected the two forms, established laboratory colonies, and docu ... | 0 | 25391959 |
| the larvicidal activity of agave sisalana against l4 larvae of aedes aegypti is mediated by internal necrosis and inhibition of nitric oxide production. | dengue is a viral disease that affects about 50 million people per year around the world. the aim of this study was to investigate the larvicidal activity of agave sisalana crude extract in order to develop a new insecticide against aedes aegypti. in larvicidal activity assays, fourth-stage ae. aegypti larvae were exposed to different concentrations of a. sisalana crude extract for 3, 6, 12, and 24 h for determining the lc50. next, we explored its cytotoxic activity by flow cytometry. furthermor ... | 2015 | 25395257 |
| chikungunya. | chikungunya is a rapidly emerging infectious disease caused by a virus of the genus alphavirus, family togaviridae. most commonly, patients have an acute onset of fever with often debilitating symmetric joint discomfort that can relapse months after the initial infection. this infection is typically transmitted by the bite of an infected aedes aegypti or aedes albopictus mosquito, vectors that also transmit dengue and yellow fever. special operations forces medical providers should be aware of t ... | 2014 | 25399382 |
| dengue fever in europe: could there be an epidemic in the future? | dengue virus (denv) is the arbovirus with the widest impact on human health. although its dispersal is partially conditioned by environmental constraints that limit the distribution of its main vector (aedes aegypti), denv has been spreading geographically in recent times, but mostly afflicting tropical and subtropical regions. with no prophylactic vaccine or specific therapeutics available, vector control remains the best alternative to restrain its circulation. moreover, the establishment of t ... | 2015 | 25399556 |
| laboratory evaluation of indian medicinal plants as repellents against malaria, dengue, and filariasis vector mosquitoes. | mosquito-borne diseases have an economic impact, including loss in commercial and labor outputs, particularly in countries with tropical and subtropical climates; however, no part of the world is free from vector-borne diseases. mosquitoes are the carriers of severe and well-known illnesses such as malaria, arboviral encephalitis, dengue fever, chikungunya fever, west nile virus, and yellow fever. these diseases produce significant morbidity and mortality in humans and livestock around the world ... | 2015 | 25399815 |
| promoting health education and public awareness about dengue and its mosquito vector in saudi arabia. | currently, dengue fever is considered as the main health problem in several parts (mekkah, jeddah, jazan and najran) of kingdom of saudi arabia (ksa) with dramatically increase in the number of cases reported every year. this is associated with obvious ineffectiveness in the recent control and management programs for the mosquito vector (aedes aegypti). here, we suggested promoting the health education and public awareness among saudi people to improve the control of dengue mosquito vector. seve ... | 2014 | 25403705 |
| estimation of aedes aegypti (diptera: culicidae) population size and adult male survival in an urban area in panama. | traditional mosquito control strategies rely heavily on the use of chemical insecticides. however, concerns about the efficiency of traditional control methods, environmental impact and emerging pesticide resistance have highlighted the necessity for developing innovative tools for mosquito control. some novel strategies, including release of insects carrying a dominant lethal gene (ridl®), rely on the sustained release of modified male mosquitoes and therefore benefit from a thorough understand ... | 2014 | 25410991 |
| dengue virus 4 (denv-4) re-emerges after 30 years in brazil: cocirculation of denv-2, denv-3, and denv-4 in bahia. | dengue fever (df) is a mosquito-borne viral disease of great concern in tropical and subtropical regions of the world. one important cause of the increase in df is rapid development and urbanization has led to proliferation of the aedes aegypti mosquito, the vector responsible for transmission of the illness. surveillance of dengue virus (denv) infection in brazil shows the predominance of denv-1, denv-2, and denv-3 until 2010. this study reports the reappearance of denv-4 in brazil for the firs ... | 2015 | 25420650 |
| susceptibility of florida aedes aegypti and aedes albopictus to dengue viruses from puerto rico. | locally acquired dengue cases in the continental u.s. are rare. however, outbreaks of dengue-1 during 2009, 2010, and 2013 in florida and dengue-1 and -2 in texas suggest vulnerability to transmission. travel and commerce between puerto rico and the u.s. mainland is common, which may pose a risk for traveler-imported dengue cases. mosquitoes were collected in florida and used to evaluate their susceptibility to dengue viruses (denv) from puerto rico. aedes aegypti and ae. albopictus were suscept ... | 2014 | 25424270 |
| application of post-pcr methods for analysis of mosquito densovirus. | two clades of aedes densovirus, aedes aegypti densovirus and aedes albopictus densovirus, were classified according to the origin of isolation. these two densoviruses were isolated from indigenous mosquitoes and mosquito cell lines, respectively. this group of invertebrate viruses belongs to the subfamily densovirinae of the parvoviridae family and infects only insects. several types of densoviruses have been isolated from mosquitoes especially aedes aegypti and aedes albopictus, which are impor ... | 2014 | 25427347 |
| species composition, seasonal occurrence, habitat preference and altitudinal distribution of malaria and other disease vectors in eastern nepal. | it is increasingly recognized that climate change can alter the geographical distribution of vector-borne diseases (vbds) with shifts of disease vectors to higher altitudes and latitudes. in particular, an increasing risk of malaria and dengue fever epidemics in tropical highlands and temperate regions has been predicted in different climate change scenarios. the aim of this paper is to expand the current knowledge on the seasonal occurrence and altitudinal distribution of malaria and other dise ... | 2014 | 25430654 |
| [chikungunya, an emerging viral disease. proposal of an algorithm for its clinical management]. | chikungunya fever (chik) is an emerging viral disease. it is caused by the chikungunya virus, an alphavirus from the togaviridae family. it is transmitted to humans by the bite of infected mosquitoes, mainly aedes aegypti and aedes albopictus. they are also involved in the transmission of dengue, malaria, etc. chik is now endemic in any region of africa and southeast-asia. cases of chik have been reported in america, the caribbean, and europe (france, italy and spain). there are reservoirs of th ... | 2017 | 25440971 |
| impact of insecticide resistance on the field control of aedes aegypti in the state of são paulo. | the need to control dengue transmission by means of insecticides has led to the development of resistance to most of the products used worldwide against mosquitoes. in the state of são paulo, the superintendência de controle de endemias (sucen) has annually monitored the susceptibility of aedes aegypti to insecticides since 1996; since 1999, surveys were conducted in collaboration with the national network of laboratories (morenaa network) and were coordinated by the ministry of health. in this ... | 2014 | 25467257 |
| assessment of the relationship between entomologic indicators of aedes aegypti and the epidemic occurrence of dengue virus 3 in a susceptible population, são josé do rio preto, são paulo, brazil. | the aims of this study were to describe the occurrence of dengue in space and time and to assess the relationships between dengue incidence and entomologic indicators. we selected the dengue autochthonous cases that occurred between september 2005 and august 2007 in são josé do rio preto to calculate incidence rates by month, year and census tracts. the monthly incidence rates of the city were compared to the monthly breteau indices (bi) of the são josé do rio region. between december 2006 and f ... | 2015 | 25484110 |
| dengue and chikungunya: long-distance spread and outbreaks in naïve areas. | mosquito-borne virus infections, such as dengue and chikungunya, are continuously expanding their geographical range. the dengue virus, which is known to be a common cause of febrile illness in tropical areas of the old world, is now widespread in the americas. in most affected areas, all the four dengue virus serotypes have circulated. recently, small clusters of dengue have been identified also in southern europe during the hot season. the chikungunya virus, initially restricted to central afr ... | 2014 | 25491436 |
| temporal abundance of aedes aegypti in manaus, brazil, measured by two trap types for adult mosquitoes. | a longitudinal study was conducted in manaus, brazil, to monitor changes of adult aedes aegypti (l.) abundance. the objectives were to compare mosquito collections of two trap types, to characterise temporal changes of the mosquito population, to investigate the influence of meteorological variables on mosquito collections and to analyse the association between mosquito collections and dengue incidence. mosquito monitoring was performed fortnightly using mosquitraps (mqt) and bg-sentinel (bgs) t ... | 2014 | 25494470 |
| the effect of virus-blocking wolbachia on male competitiveness of the dengue vector mosquito, aedes aegypti. | the bacterial endosymbiont wolbachia blocks the transmission of dengue virus by its vector mosquito aedes aegypti, and is currently being evaluated for control of dengue outbreaks. wolbachia induces cytoplasmic incompatibility (ci) that results in the developmental failure of offspring in the cross between wolbachia-infected males and uninfected females. this increases the relative success of infected females in the population, thereby enhancing the spread of the beneficial bacterium. however, w ... | 2014 | 25502564 |
| [ovitraps evaluation for surveillance and control of aedes aegypti in two urban settlements of urabá, antioquia]. | aedes (stegomyia) aegypti is the main vector of dengue. chemical insecticides have been used to control the mosquito and it has developed resistance. it is necessary to evaluate alternative strategies that are efficient, economical and easy to apply, such as ovitraps with bacillus thuringiesis israeliensis . | 2014 | 25504128 |
| [evaluation of lethal ovitraps as a strategy for aedes aegypti control]. | dengue fever is a vector-borne viral disease of major public health importance. in the absence of a vaccine, control measures are primarily focused on reducing the mosquito vector. however, these strategies are very expensive, and the use of lethal ovitraps could contribute, in a practical manner, to the design of cost-effective strategies for vector control. | 2014 | 25504133 |
| a database of circadian and diel rhythmic gene expression in the yellow fever mosquito aedes aegypti. | the mosquito species aedes aegypti is the primary vector of many arboviral diseases, including dengue and yellow fevers, that are responsible for a large worldwide health burden. the biological rhythms of mosquitoes regulate many of the physiological processes and behaviors that influence the transmission of these diseases. for insight into the molecular basis of biological rhythms, diel and circadian gene expression profiling has been carried out for many species. to bring these resources to ae ... | 2014 | 25516260 |
| aedes aegypti and aedes albopictus habitat preferences in south texas, usa. | the south texas region has a historical record of occasional dengue outbreaks. the recent introduction of chikungunya virus to the caribbean suggests that this disease may be a concern as well. six different cities and three field habitat types (residential, tire shops, and cemeteries) were examined for evidence of habitat and longitudinal preference of two vector species, aedes aegypti and aedes albopictus. a. aegypti was more prevalent in tire shop sites, while a. albopictus was more prevalent ... | 2014 | 25520559 |
| cpb1 of aedes aegypti interacts with denv2 e protein and regulates intracellular viral accumulation and release from midgut cells. | aedes aegypti is a principal vector responsible for the transmission of dengue viruses (denv). to date, vector control remains the key option for dengue disease management. to develop new vector control strategies, a more comprehensive understanding of the biological interactions between denv and ae. aegypti is required. in this study, a cdna library derived from the midgut of female adult ae. aegypti was used in yeast two-hybrid (y2h) screenings against denv2 envelope (e) protein. among the man ... | 2014 | 25521592 |
| são paulo urban heat islands have a higher incidence of dengue than other urban areas. | urban heat islands are characterized by high land surface temperature, low humidity, and poor vegetation, and considered to favor the transmission of the mosquito-borne dengue fever that is transmitted by the aedes aegypti mosquito. we analyzed the recorded dengue incidence in sao paulo city, brazil, in 2010-2011, in terms of multiple environmental and socioeconomic variables. geographical information systems, thermal remote sensing images, and census data were used to classify city areas accord ... | 2015 | 25523076 |
| effect of confertifolin from polygonum hydropiper l. against dengue vector mosquitoes aedes aegypti l. | the essential oil from the leaves of polygonum hydropiper l. (polygonaceae) was tested against aedes aegypti l. the lc50 values were 190.72 and 234.37 ppm against second and fourth instar larvae of a. aegypti, respectively. confertifolin (6,6,9a-trimethy l-4,5,5a,6,7,8,9,9a-octahydronaphtho [1,2-c] furan-3 (1h)-one) was isolated from the essential oil of p. hydropiper leaves using silica gel column chromatography. the lc50 values were 2.90 and 2.96 ppm for second and fourth instar larvae of a. a ... | 2015 | 25523289 |
| larvicidal activity of the leaf extracts of spondias mombin linn. (anacardiaceae) from various solvents against malarial, dengue and filarial vector mosquitoes (diptera: culicidae). | aedes aegypti, anopheles gambiae and culex quinquefasciatus are vector mosquitoes of dengue, malaria, and filariasis, respectively. since no vaccine is available to treat these diseases, the control of the main mosquito vectors is essential. as conventional insecticides have limited success, plants may be alternative larvicidal agents, since they contain a rich source of bioactive chemicals. the aim of this study was to evaluate the larvicidal activity of methanol crude extract, hexane, dichloro ... | 2014 | 25540962 |
| dengue vectors prevalence and the related risk factors involved in the transmission of dengue in thiruvananthapuram district, kerala, south india. | a longitudinal, entomological and virological study was conducted from 2007 to 2010 in four dengue fever affected areas of thiruvananthapuram district, kerala to understand the risk factors involved in the dengue transmission. | 2014 | 25540964 |
| use of different coloured ovitraps in the surveillance of aedes mosquitoes in an arid-urban area of western rajasthan, india. | in the absence of any commercially available dengue vaccine or antiviral therapy, controlling the primary mosquito vector, aedes aegypti, is currently the only means to prevent dengue outbreaks. ovitraps are being employed as a sensitive method for detecting the presence of ae. aegypti. size, colour, material, paddle and use of oviposition attractant have been reported as important factors influencing the efficacy of ovitraps. | 2014 | 25540965 |
| eco-virological survey of aedes mosquito larvae in selected dengue outbreak areas in malaysia. | background & objectivesi: transovarial transmission of dengue virus in the aedes vectors is now a well-documented phenomenon reported from many parts of the endemic areas in the world, which played an important role in initiating and maintaining the outbreak in human populations. this study investigated the factors affecting breeding habitats and the relationship with transovarial dengue virus in larvae of aedes aegypti and ae. albopictus. | 2014 | 25540966 |
| the role of male harassment on female fitness for the dengue vector mosquito aedes aegypti. | sexual harassment studies in insects suggest that females can incur several kinds of costs from male harassment and mating. here, we examined direct and indirect costs of male harassment on components of female fitness in the predominantly monandrous mosquito aedes aegypti. to disentangle the costs of harassment versus the costs of mating, we held females at a low or high density with males whose claspers were modified to prevent insemination, and compared these to females held with normal males ... | 0 | 25544799 |
| larvicidal and repellent properties of streptomyces sp. vitjs4 crude extract against anopheles stephensi, aedes aegypti and culex quinquefasciatus (diptera: culicidae). | the aim of the present study was to assess the larvicidal and repellent properties of marine streptomyces sp. vitjs4 crude extracts. the marine soil samples were collected from the puducherry coast, tamil nadu, india. the isolate streptomyces sp. vitjs4 was taxonomically characterized and identified. the ethyl acetate crude extract tested for larvicidal property showed 100% mortality for all the 3 species after 24 h exposure against the early fourth instar larvae of malarial vector--anopheles st ... | 2014 | 25546945 |
| aealrack1 expression and localization in response to stress in c6/36 ht mosquito cells. | the receptor for activated c kinase 1 (rack1), a scaffold protein member of the tryptophan-aspartate (wd) repeat family, folds in a seven-bladed β-propeller structure that permits the association of proteins to form active complexes. mosquitoes of the genus aedes sp., are vectors of virus producing important diseases such as: dengue, chikungunya and yellow fever. based on the highly conserved gene sequence of aeaerack1 of the mosquito aedes aegypti we characterized the mrna and protein of the ho ... | 2015 | 25555378 |
| antipathogen genes and the replacement of disease-vectoring mosquito populations: a model-based evaluation. | recently, genetic strategies aimed at controlling populations of disease-vectoring mosquitoes have received considerable attention as alternatives to traditional measures. theoretical studies have shown that female-killing (fk), antipathogen (ap), and reduce and replace (r&r) strategies can each decrease the number competent vectors. in this study, we utilize a mathematical model to evaluate impacts on competent aedes aegypti populations of fk, ap, and r&r releases as well as hybrid strategies t ... | 2014 | 25558284 |
| naturally-acquired dengue virus infections do not reduce short-term survival of infected aedes aegypti from ho chi minh city, vietnam. | transmission of dengue virus (denv) from mosquito to human is dependent upon the survival of the mosquito beyond the virus extrinsic incubation period. previous studies report conflicting results of the effects of denv on aedes aegypti survival. here, we describe the effect of denv on the short-term survival (up to 12 d) of 4,321 ae. aegypti mosquitoes blood-fed on 150 ns1-positive dengue patients hospitalized in the hospital for tropical diseases, ho chi minh city, vietnam. mosquito survival wa ... | 2015 | 25561566 |
| dendritic cells in dengue virus infection: targets of virus replication and mediators of immunity. | dendritic cells (dcs) are sentinels of the immune system and detect pathogens at sites of entry, such as the skin. in addition to the ability of dcs to control infections directly via their innate immune functions, dcs help to prime adaptive b- and t-cell responses by processing and presenting antigen in lymphoid tissues. infected aedes aegypti or aedes albopictus mosquitoes transmit the four dengue virus (denv) serotypes to humans while probing for small blood vessels in the skin. denv causes t ... | 2014 | 25566258 |
| spatial genetic structure of aedes aegypti mosquitoes in mainland southeast asia. | aedes aegypti mosquitoes originated in africa and are thought to have spread recently to southeast asia, where they are the major vector of dengue. thirteen microsatellite loci were used to determine the genetic population structure of a. aegypti at a hierarchy of spatial scales encompassing 36 sites in myanmar, cambodia and thailand, and two sites in sri lanka and nigeria. low, but significant, genetic structuring was found at all spatial scales (from 5 to >2000 km) and significant f is values ... | 2010 | 25567928 |
| pyrethroid-resistance and presence of two knockdown resistance (kdr) mutations, f1534c and a novel mutation t1520i, in indian aedes aegypti. | control of aedes aegypti, the mosquito vector of dengue, chikungunya and yellow fever, is a challenging task. pyrethroid insecticides have emerged as a preferred choice for vector control but are threatened by the emergence of resistance. the present study reports a focus of pyrethroid resistance and presence of two kdr mutations--f1534c and a novel mutation t1520i, in ae. aegypti from delhi, india. | 2015 | 25569164 |
| hptlc analysis of scoparia dulcis linn (scrophulariaceae) and its larvicidal potential against dengue vector aedes aegypti. | this study evaluates the larvicidal activity of scoparia dulcis aqueous extract against dengue vector and determines its major chemical components. the extract was tested at various concentrations ranging from 0.1 to 2 mg/ml against aedes aegypti larvae. the extracts displayed significant larvicidal efficacy against ae. aegypt species after 24 h exposure revealing lc50 of 3.3835 (mg/ml) and lc90 of 5.7578 (mg/ml). finger printing profile carried out by camag automatic tlc sample applicator progr ... | 2015 | 25573588 |
| investigations of koutango virus infectivity and dissemination dynamics in aedes aegypti mosquitoes. | aedes aegypti has already been implicated in the emergence of dengue and chikungunya viruses in the southern us. vector competence is the ability of a mosquito species to support transmission of an arbovirus, which is bounded by its ability to support replication and dissemination of the virus through the mosquito body to the salivary glands to be expectorated in the saliva at the time of feeding on a vertebrate host. here, we investigate the vector competence of a. aegypti for the arbovirus kou ... | 2014 | 25574140 |
| she's a femme fatale: low-density larval development produces good disease vectors. | two hypotheses for how conditions for larval mosquitoes affect vectorial capacity make opposite predictions about the relationship of adult size and frequency of infection with vector-borne pathogens. competition among larvae produces small adult females. the competition-susceptibility hypothesis postulates that small females are more susceptible to infection and predicts frequency of infection should decrease with size. the competition-longevity hypothesis postulates that small females have low ... | 0 | 25591112 |
| entomological impact and social participation in dengue control: a cluster randomized trial in fortaleza, brazil. | this study intended to implement a novel intervention strategy, in brazil, using an ecohealth approach and analyse its effectiveness and costs in reducing aedes aegypti vector density as well as its acceptance, feasibility and sustainability. the intervention was conducted from 2012 to 2013 in the municipality of fortaleza, northeast brazil. | 0 | 25604760 |
| long-lasting insecticide-treated house screens and targeted treatment of productive breeding-sites for dengue vector control in acapulco, mexico. | long-lasting insecticidal net screens (llis) fitted to domestic windows and doors in combination with targeted treatment (tt) of the most productive aedes aegypti breeding sites were evaluated for their impact on dengue vector indices in a cluster-randomised trial in mexico between 2011 and 2013. | 0 | 25604761 |
| improved dengue fever prevention through innovative intervention methods in the city of salto, uruguay. | uruguay is located at the southern border of aedes aegypti distribution on the south american sub-continent. the reported dengue cases in the country are all imported from surrounding countries. one of the cities at higher risk of local dengue transmission is salto, a border city with heavy traffic from dengue endemic areas. | 0 | 25604764 |
| standard operating procedures for standardized mass rearing of the dengue and chikungunya vectors aedes aegypti and aedes albopictus (diptera: culicidae) - i - egg quantification. | quantification of eggs prior to rearing the immature stages of mosquitoes is an essential step in establishing a standardized mass rearing system. to develop a simple and accurate method of egg quantification for aedes aegypti and aedes albopictus, the relationship between egg number and weight, as well as egg number and volume, were studied. | 2015 | 25614052 |
| use of insecticide-treated house screens to reduce infestations of dengue virus vectors, mexico. | dengue prevention efforts rely on control of virus vectors. we investigated use of insecticide-treated screens permanently affixed to windows and doors in mexico and found that the screens significantly reduced infestations of aedes aegypti mosquitoes in treated houses. our findings demonstrate the value of this method for dengue virus vector control. | 0 | 25625483 |
| awareness and support of release of genetically modified "sterile" mosquitoes, key west, florida, usa. | after a dengue outbreak in key west, florida, during 2009-2010, authorities, considered conducting the first us release of male aedes aegypti mosquitoes genetically modified to prevent reproduction. despite outreach and media attention, only half of the community was aware of the proposal; half of those were supportive. novel public health strategies require community engagement. | 0 | 25625795 |
| dengue in brazil and colombia: a study of knowledge, attitudes, and practices. | introduction this study was conducted in brazil and colombia,where dengue is endemic and vector control programs use chemical insecticides. methods we identified knowledge, attitudes, and practices about dengue and determined the infestation levels of aedes aegypti in one brazilian and four colombian communities. results the surveys show knowledge of the vector, but little knowledge about diagnosis, prognosis, and treatment. vector infestation indices show brazil to have good relative control, w ... | 2015 | 25626660 |
| sexual harassment and feeding inhibition between two invasive dengue vectors. | two invasive mosquitoes, aedes aegypti and aedes albopictus, have been interacting during the course of a rapid range expansion by a. albopictus. we investigated the potential for interspecific feeding interference by male mosquitoes interacting with females within and between these species. a. aegypti feeding on both sugar and blood was suppressed when females of this species were exposed to a. albopictus males, but no change was observed when exposed to conspecifics. a. albopictus feeding was ... | 2015 | 25628511 |
| comparison of vector competence of aedes mediovittatus and aedes aegypti for dengue virus: implications for dengue control in the caribbean. | aedes mediovittatus mosquitoes are found throughout the greater antilles in the caribbean and often share the same larval habitats with ae. aegypti, the primary vector for dengue virus (denv). implementation of vector control measures to control dengue that specifically target ae. aegypti may not control denv transmission in puerto rico (pr). even if ae. aegypti is eliminated or denv refractory mosquitoes are released, denv transmission may not cease when other competent mosquito species like ae ... | 2015 | 25658951 |
| antiviral activity of chloroquine against dengue virus type 2 replication in aotus monkeys. | dengue virus (denv) of the flaviviridae family is a single positive-stranded rna virus that is transmitted by aedes aegypti and aedes albopictus mosquitoes. the objective of this study was to investigate the use of chloroquine (clq) as an antiviral drug against dengue virus in monkeys. to analyze the action of the drug in vivo, nonhuman primates groups (aotus azarai infulatus) were inoculated with a subcutaneous injection of a virulent strain of denv-2, treated and untreated clq. blood hematolog ... | 2015 | 25664975 |
| synthesis and characterization of silver nanoparticles using gmelina asiatica leaf extract against filariasis, dengue, and malaria vector mosquitoes. | mosquitoes are blood-feeding insects and serve as the most important vectors for spreading human diseases such as malaria, yellow fever, dengue fever, and filariasis. the continued use of synthetic insecticides has resulted in resistance in mosquitoes. synthetic insecticides are toxic and affect the environment by contaminating soil, water, and air, and then natural products may be an alternative to synthetic insecticides because they are effective, biodegradable, eco-friendly, and safe to envir ... | 2015 | 25666372 |
| surveillance of aedes aegypti: comparison of house index with four alternative traps. | the mosquito aedes aegypti, vector of dengue, chikungunya and yellow fever viruses, is an important target of vector control programs in tropical countries. most mosquito surveillance programs are still based on the traditional household larval surveys, despite the availability of new trapping devices. we report the results of a multicentric entomological survey using four types of traps, besides the larval survey, to compare the entomological indices generated by these different surveillance to ... | 2015 | 25668559 |
| tackling the growing threat of dengue: phyllanthus niruri-mediated synthesis of silver nanoparticles and their mosquitocidal properties against the dengue vector aedes aegypti (diptera: culicidae). | mosquitoes are vectors of devastating pathogens and parasites, causing millions of deaths every year. dengue is a mosquito-borne viral infection found in tropical and subtropical regions around the world. recently, transmission has strongly increased in urban and semiurban areas, becoming a major international public health concern. aedes aegypti (diptera: culicidae) is the primary vector of dengue. the use of synthetic insecticides to control aedes mosquitoes lead to high operational costs and ... | 2015 | 25669140 |
| households as foci for dengue transmission in highly urban vietnam. | dengue control programs commonly employ reactive insecticide spraying around houses of reported cases, with the assumption that most dengue virus (denv) transmission occurs in the home. focal household transmission has been demonstrated in rural settings, but it is unclear whether this holds true in dense and mobile urban populations. we conducted a prospective study of dengue clustering around households in highly urban ho chi minh city, vietnam. | 2015 | 25680106 |
| ovicidal and adulticidal potential of leaf and seed extract of albizia lebbeck (l.) benth. (family: fabaceae) against culex quinquefasciatus, aedes aegypti, and anopheles stephensi (diptera: culicidae). | several diseases are associated to the mosquito-human interaction. mosquitoes are the carriers of severe and well-known illnesses such as malaria, arboviral encephalitis, dengue fever, chikungunya fever, west nile virus, and yellow fever. these diseases produce significant morbidity and mortality in humans and livestock around the world. in the present study, hexane, benzene, chloroform, ethyl acetate, and methanol extracts of leaf and seed of albizia lebbeck were assayed for their toxicity agai ... | 2015 | 25681143 |
| dengue: recent past and future threats. | this article explores four key questions about statistical models developed to describe the recent past and future of vector-borne diseases, with special emphasis on dengue: (1) how many variables should be used to make predictions about the future of vector-borne diseases? (2) is the spatial resolution of a climate dataset an important determinant of model accuracy? (3) does inclusion of the future distributions of vectors affect predictions of the futures of the diseases they transmit? (4) whi ... | 0 | 25688021 |
| climate change influences on global distributions of dengue and chikungunya virus vectors. | numerous recent studies have illuminated global distributions of human cases of dengue and other mosquito-transmitted diseases, yet the potential distributions of key vector species have not been incorporated integrally into those mapping efforts. projections onto future conditions to illuminate potential distributional shifts in coming decades are similarly lacking, at least outside europe. this study examined the global potential distributions of aedes aegypti and aedes albopictus in relation ... | 0 | 25688023 |
| evolution of dengue disease and entomological monitoring in santa cruz, bolivia 2002 - 2008. | in the context of a rapid increase of dengue cases in the americas, a monitoring system based on systematic serological control (igm) of patients consulting for suspected dengue was developed in bolivia at the end of the 1990s. in the most affected city of santa cruz, this system was complemented by an entomological surveillance program based on periodical search for immature stages of aedes aegypti in dwelling water-holding containers. here, we analyze these data and describe dengue patterns ov ... | 2015 | 25706631 |
| rapid selection against arbovirus-induced apoptosis during infection of a mosquito vector. | millions of people are infected each year by arboviruses (arthropod-borne viruses) such as chikungunya, dengue, and west nile viruses, yet for reasons that are largely unknown, only a relatively small number of mosquito species are able to transmit arboviruses. understanding the complex factors that determine vector competence could facilitate strategies for controlling arbovirus infections. apoptosis is a potential antiviral defense response that has been shown to be important in other virus-ho ... | 2015 | 25713358 |
| a multipurpose, high-throughput single-nucleotide polymorphism chip for the dengue and yellow fever mosquito, aedes aegypti. | the dengue and yellow fever mosquito, aedes aegypti, contributes significantly to global disease burden. genetic study of aedes aegypti is essential to understanding its evolutionary history, competence as a disease vector, and the effects and efficacy of vector control methods. the prevalence of repeats and transposable elements in the aedes aegypti genome complicates marker development and makes genome-wide genetic study challenging. to overcome these challenges, we developed a high-throughput ... | 2015 | 25721127 |
| examination of the genetic basis for sexual dimorphism in the aedes aegypti (dengue vector mosquito) pupal brain. | most animal species exhibit sexually dimorphic behaviors, many of which are linked to reproduction. a number of these behaviors, including blood feeding in female mosquitoes, contribute to the global spread of vector-borne illnesses. however, knowledge concerning the genetic basis of sexually dimorphic traits is limited in any organism, including mosquitoes, especially with respect to differences in the developing nervous system. | 2014 | 25729562 |
| cytostatic and genotoxic effect of temephos in human lymphocytes and hepg2 cells. | temephos is an organophosphorus pesticide that is used in control campaigns against aedes aegypti mosquitoes, which transmit dengue. in spite of the widespread use of temephos, few studies have examined its genotoxic potential. the aim of this study was to evaluate the cytotoxic, cytostatic and genotoxic effects of temephos in human lymphocytes and hepatoma cells (hepg2). the cytotoxicity was evaluated with simultaneous staining (fda/etbr). the cytostatic and genotoxic effects were evaluated usi ... | 2015 | 25746384 |