Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| investigations to reveal the nature of interactions of human hemoglobin with curcumin using optical techniques. | curcumin (cur) is an important bioactive compound present in the rhizome of curcuma longa. herein, we report the interaction of cur with human hemoglobin (hb) using various biophysical methods viz., fluorescence, uv absorption, resonance light scattering spectra (rls), synchronous fluorescence, fluorescence anisotropy, circular dichroism (cd) and three-dimensional fluorescence. there was a considerable quenching of the intrinsic fluorescence of hb upon binding to cur through dynamic quenching me ... | 2013 | 23022269 |
| curcumin induces apoptosis of triple-negative breast cancer cells by inhibition of egfr expression. | curcumin is the major component of the spice turmeric, extracted from the rhizomes of the plant curcuma longa. it exerts a number of therapeutic effects, including the inhibition of cancer cell proliferation. however, the anti-carcinogenic mechanism of curcumin has not been fully elucidated. triple-negative breast cancer (tnbc), which lacks expression of the estrogen receptor (er), progesterone receptor (pr) and epidermal growth factor receptor 2 (her2/egfr2), is an aggressive breast cancer phen ... | 2012 | 23023821 |
| p-gp upregulation may be blocked by natural curcuminoids, a novel class of chemoresistance-preventing agent. | once multidrug resistance (mdr) occurs in cancer cells, it is very difficult to reverse since overexpression of p-glycoprotein (p-gp) is accompanied by altered expression of numerous other activated target genes. previously, we reported that curcumin pretreatment would be an ideal method to prevent acquired drug resistance induced by adriamycin, administered prior to the development of mdr. to further confirm the previous results, we examined the potency of 3 forms of curcuminoids present in tur ... | 2013 | 23023936 |
| interaction of over-the-counter drugs with curcumin: influence on stability and bioactivities in intestinal cells. | curcumin, a major constituent in rhizomes of curcuma longa l., has shown various biological activities. it has widely been used as a food additive to provide potential health benefits. in the present study, we investigated changes in chemical stability and cytotoxic properties of curcumin and commonly consumed over-the-counter (otc) drugs including ibuprofen, acetylsalicylic acid (asp), and acetaminophen (aap), through their interactions. stability of curcumin was significantly improved in phosp ... | 2012 | 23025432 |
| comparative evaluation of the efficacy of turmeric and curcumin as a local drug delivery system: a clinicomicrobiological study. | when host defense mechanisms fail to contain or eliminate pathogenic periodontal microflora, an exaggerated host response releases inflammatory mediators, which in turn destroy soft and hard tissue components of the periodontium. this in vitro and in vivo study comparatively evaluated the adjunctive efficacy of turmeric, curcumin, and traditional nonsurgical methods for treating periodontal pockets. turmeric and curcumin chips were prepared and the in vitro release pattern was estimated using a ... | 2012 | 23032234 |
| antioxidant activity and protecting health effects of common medicinal plants. | medicinal plants are traditionally used in folk medicine as natural healing remedies with therapeutic effects such as prevention of cardiovascular diseases, inflammation disorders, or reducing the risk of cancer. in addition, pharmacological industry utilizes medicinal plants due to the presence of active chemical substances as agents for drug synthesis. they are valuable also for food and cosmetic industry as additives, due to their preservative effects because of the presence of antioxidants a ... | 2012 | 23034115 |
| multiple antidepressant potential modes of action of curcumin: a review of its anti-inflammatory, monoaminergic, antioxidant, immune-modulating and neuroprotective effects. | curcumin is the principal curcuminoid of the popular indian spice turmeric and has attracted increasing attention for the treatment of a range of conditions. research into its potential as a treatment for depression is still in its infancy, although several potential antidepressant mechanisms of action have been identified. research completed to date on the multiple effects of curcumin is reviewed in this paper, with a specific emphasis on the biological systems that are compromised in depressio ... | 2012 | 23035031 |
| curcumin reduces cisplatin-induced neurotoxicity in ngf-differentiated pc12 cells. | the potential neuroprotective benefits of curcumin against cisplatin neurotoxicity were investigated. curcumin is a polyphenol derived from the rhizome of curcuma longa whose pharmacological effects include antioxidant, anti-inflammatory and anti-cancer properties. cisplatin is a potent chemotherapeutic drug with activity against a wide variety of tumors, although it has notorious side effects. cisplatin neurotoxicity is clinically evident in patients that have undergone a full course of chemoth ... | 2013 | 23036615 |
| development of curcumin nanocrystal: physical aspects. | curcumin, a naturally occuring polyphenolic phytoconstituent, is isolated from the rhizomes of curcuma longa linn. (zingiberaceae). it is water insoluble under acidic or neutral conditions but dissolves in alkaline environment. in neutral or alkaline conditions, curcumin is highly unstable undergoing rapid hydrolytic degradation to feruloyl methane and ferulic acid. thus, the use of curcumin is limited by its poor aqueous solubility in acidic or neutral conditions and instability in alkaline ph. ... | 2013 | 23047816 |
| clinical evaluation of rasayana compound as an adjuvant in the management of tuberculosis with anti-koch's treatment. | tuberculosis (tb) continues to intimidate the human race since time immemorial not only due to its effects as a medical malady, but also by its impact as a social and economic tragedy. at the dawn of the new millennium, we are still mute witnesses to the silent yet efficient march of this sagacious disease, its myriad manifestations and above all its unequalled, vicious power. through the millennia, tb never ever disappeared from the developing world. in 1991, the world health assembly (wha) res ... | 2012 | 23049182 |
| curcumin protects against staurosporine toxicity in rat neurons. | curcumin is extracted from the turmeric plant (curcuma longa linn.) and is widely used as a food additive and traditional medicine. the present study investigated the activity of curcumin against staurosporine (sts) toxicity in cell culture. | 2012 | 23054638 |
| herbal medicines for the prevention of alcoholic liver disease: a review. | long-term excess alcohol exposure leads to alcoholic liver disease (ald)-a global health problem without effective therapeutic approach. ald is increasingly considered as a complex and multifaceted pathological process, involving oxidative stress, inflammation and excessive fatty acid synthesis. over the past decade, herbal medicines have attracted much attention as potential therapeutic agents in the prevention and treatment of ald, due to their multiple targets and less toxic side effects. sev ... | 2012 | 23058988 |
| curcumin increases rat mesenchymal stem cell osteoblast differentiation but inhibits adipocyte differentiation. | curcumin is a phenolic natural product isolated from the rhizome of curcuma longa (turmeric) and has effects on bone health and fat formation. the bone marrow mesenchymal stem cells (mscs) are multipotent cells capable of differentiating into osteoblasts and adipocytes. osteoblast differentiation of mscs can be a result of upregulation of heme oxygenase (ho)-1 expression. curcumin can potently induce ho-1 expression. | 2012 | 23060694 |
| curcumin inhibits hmgb1 releasing and attenuates concanavalin a-induced hepatitis in mice. | curcumin, a polyphenol extracted from the plant curcuma longa, exhibits a number of pharmacological properties and has been used for the treatment of inflammatory diseases. however, the potential protective effects of curcumin in inflammatory liver diseases have not been clearly elucidated. thus, the current study aimed to investigate the beneficial effects of curcumin on hepatic injury induced by concanavalin a (con a), and its possible molecular mechanisms in mice. acute live injury model was es ... | 2012 | 23063543 |
| p-glycoprotein mediated efflux in caco-2 cell monolayers: the influence of herbals on digoxin transport. | several herbal medicines are concomitantly used with conventional medicines with a resultant increase in the recognition of herb-drug interactions. the phytomedicines vernonia amygdalina delile (va), family asteraceae; azadiractha indica a. juss (nl), family meliaceae; morinda lucida benth (mlb), family rubiaceae; cymbopogon citratus stapf (lg), family poaceae; curcuma longa l. (cur), family zingiberaceae; carica papaya l. (cp), family caricaceae and tapinanthus sessilifolius blume (ml), family ... | 2012 | 23064285 |
| dietary curcumin counteracts extracellular transthyretin deposition: insights on the mechanism of amyloid inhibition. | the transthyretin amyloidoses (attr) are devastating diseases characterized by progressive neuropathy and/or cardiomyopathy for which novel therapeutic strategies are needed. we have recently shown that curcumin (diferuloylmethane), the major bioactive polyphenol of turmeric, strongly suppresses ttr fibril formation in vitro, either by stabilization of ttr tetramer or by generating nonfibrillar small intermediates that are innocuous to cultured neuronal cells. in the present study, we aim to ass ... | 2013 | 23069388 |
| curcumin reduces the antimicrobial activity of ciprofloxacin against salmonella typhimurium and salmonella typhi. | typhoidal and non-typhoidal infection by salmonella is a serious threat to human health. ciprofloxacin is the last drug of choice to clear the infection. ciprofloxacin, a gyrase inhibitor, kills bacteria by inducing chromosome fragmentation, sos response and reactive oxygen species (ros) in the bacterial cell. curcumin, an active ingredient from turmeric, is a major dietary molecule among asians and possesses medicinal properties. our research aimed at investigating whether curcumin modulates th ... | 2013 | 23070736 |
| combinatorial cytotoxic effects of curcuma longa and zingiber officinale on the pc-3m prostate cancer cell line. | many plant-derived products exhibit potent chemopreventive activity against animal tumor models as well as rodent and human cancer cell lines. they have low side effects and toxicity and presumably modulate the factors that are critical for cell proliferation, differentiation, senescence and apoptosis. the present study investigates the effects of some medicinal plant extracts from generally recognized as safe plants that may be useful in the prevention and treatment of cancer. | 2012 | 23072849 |
| synergistic immunosuppressive effects of the mtor inhibitor sirolimus and the phytochemical curcumin. | the immunosuppressant sirolimus and curcumin, the main principle of the turmeric spice, have shown antiproliferative effects on many human and not-human cell lines. whereas the antiproliferative effect of sirolimus is mainly mediated by inhibition of mtor, curcumin is described to affect many molecular targets which makes it unpredictable to appraise if the effects of these both substances on cell proliferation and especially on immunosuppression are additive or synergistic. to answer this quest ... | 2013 | 23079231 |
| a reduced curcuminoid analog as a novel inducer of fetal hemoglobin. | thalassemia is an inherited disorder of hemoglobin molecules that is characterized by an imbalance of α- and β-globin chain synthesis. accumulation of unbound α-globin chains in erythroid cells is the major cause of pathology in β-thalassemia. stimulation of γ-globin production can ameliorate disease severity as it combines with the α-globin to form fetal hemoglobin. we examined γ-globin-inducing effect of curcuminoids extracted from curcuma longa l. and their metabolite reduced forms in erythro ... | 2013 | 23079892 |
| curcumin attenuates lipolysis stimulated by tumor necrosis factor-α or isoproterenol in 3t3-l1 adipocytes. | curcumin, an active component derived from dietary spice turmeric (curcuma longa), has been demonstrated antihyperglycemic, antiinflammatory and hypocholesterolemic activities in obesity and diabetes. these effects are associated with decreased level of circulating free fatty acids (ffa), however the mechanism has not yet been elucidated. the flux of ffa and glycerol from adipose tissue to the blood stream primarily depends on the lipolysis of triacylglycerols in the adipocytes. adipocyte lipoly ... | 2012 | 23083815 |
| t63, a new 4-arylidene curcumin analogue, induces cell cycle arrest and apoptosis through activation of the reactive oxygen species-foxo3a pathway in lung cancer cells. | curcumin (diferuloylmethane) is a natural polyphenol product of the plant curcuma longa and has a diversity of antitumor activities. t63, a new 4-arylidene curcumin analogue, was reported to inhibit proliferation of lung cancer cells. however, its precise molecular antitumor mechanisms have not been well elucidated. here, we showed that t63 could significantly inhibit the proliferation of a549 and h460 human lung cell lines via induction of g0/g1 cell cycle arrest and apoptosis. we found that th ... | 2012 | 23085518 |
| in vitro evaluation of schistosomicidal potential of curcumin against schistosoma japonicum. | curcumin is a polyphenol derived from the dietary spice turmeric. the aim of this study was to investigate the in vitro effect of curcumin against eggs, cercariae, pre-adults, and adults of schistosoma japonicum compared to praziquantel. after incubated by different concentration of curcumin or praziquantel in different time, the percent hatching rates of eggs, the percent dead rates of cercariae, and the number of dead worms were observed. curcumin showed time- and dose-dependent schistosomicid ... | 2012 | 23088385 |
| evidence for the participation of atp-sensitive potassium channels in the antinociceptive effect of curcumin. | it has been reported that curcumin, the main active compound of curcuma longa, also known as turmeric, exhibits antinociceptive properties. the aim of this study was to examine the participation of atp-sensitive potassium channels (k(atp) channels) and, in particular, that of the l-arginine-nitric oxide-cyclic gmp-k(atp) channel pathway, in the antinociceptive effect of curcumin. | 2012 | 23091682 |
| interactions of curcumin and its derivatives with nucleic acids and their implications. | curcumin (diferuloylmethane) is a yellow polyphenol found in the rhizome of the annual herb turmeric (curcuma longa) belonging to the family zingiberaceae. its interaction with a huge number of molecular targets like cytokines, growth factors, transcription factors, receptors, pro-inflammatory enzymes, protein kinases and adhesion molecules has been studied extensively. interaction of curcumin with nucleic acids has been the focus of extensive research in recent years. curcumin is observed to be ... | 2013 | 23095000 |
| piperine potentiates the protective effects of curcumin against chronic unpredictable stress-induced cognitive impairment and oxidative damage in mice. | life event stressors are the major vulnerability factors for the development of cognitive disorders. a vital therapeutic for stress related disorders is curcumin, derived from curry spice turmeric. dietary phytochemicals are currently used as an adjuvant therapy to accelerate their therapeutic efficacy. therefore, the present study was designed to investigate the effect of curcumin and its co-administration with piperine against chronic unpredictable stress (cus)-induced cognitive impairment and ... | 2012 | 23099054 |
| 1,8-cineole protected human lipoproteins from modification by oxidation and glycation and exhibited serum lipid-lowering and anti-inflammatory activity in zebrafish. | we recently reported that a water extract of laurel or turmeric, 1,8-cineole enriched fractions, showed hypolipidemic activity in the zebrafish model. therefore, the present study investigated the cineole's anti-oxidant and anti-inflammatory activities in lipoprotein metabolism in vitro and in vivo. cineole had inhibitory effects on cupric ion-mediated oxidation of lipoproteins in general, while simultaneously enhancing ferric ion removal ability in high-density lipoprotein (hdl). hypercholester ... | 2012 | 23101510 |
| therapeutic uses ofcurcuma longa (turmeric). | curcuma longa commonly known as tumeric is traditionally used as a spice in indian food. a wide range of biological activities e.g. anticancer, antimicrobial, antiinflammatory and free radical scavenging activity of the plant suggests a logical basis for its traditional use in foodstuff. various phytothreapeutic uses ofcurcuma longa have been reviewed. | 2001 | 23105311 |
| hypoglycemic, hypolipidemic and antioxidant properties of combination ofcurcumin fromcurcuma longa, linn, and partially purified product fromabroma augusta, linn. in streptozotocin induced diabetes. | dietary spice components ofcurcuma longa andabroma augusta have been screened for their protective effect against reactive oxygen species induced lipid peroxidation. they have been found to be efficient antioxidant when administered in combination. the purpose of the study was to investigate the effect of oral administration (300mg/kg) of the aqueous extract of turmeric whose active ingredient iscurcumin andabromine powder as a hypoglycemic agent mixed with diet. the effect of this aqueous extra ... | 2002 | 23105348 |
| in vitro inhibition of lipid peroxidation in fish by turmeric (curcuma longa). | the beneficial effects of ∈-3 fatty acids on human health have been well documented. fish and fish oils are the richest sources of ∈-3 fatty acids. however, due to their high degree of unsaturation, they are highly susceptible to lipid peroxidation. regular consumption of peroxidised oils may represent a risk factor for the induction and development of atherosclerosis. in view of the above reports, it was considered necessary to study the effects of tumeric on fish lipid peroxidation during stan ... | 2006 | 23105631 |
| evaluation of the radioprotective effect of turmeric extract and vitamin e in mice exposed to therapeutic dose of radioiodine. | the aim of this study was to evaluate the radioprotective effect of turmeric extract (40 mg/kg body weight) and vitamin e (α- tocopherol acetate, 400 iu/kg body weight) supplementation on lipid peroxidation, reduced glutathione and antioxidant defense enzymes in various organs like liver, kidney and salivary glands at 24 h in adult swiss mice. (131)iodine exposure significantly increased lipid peroxidation in kidney and salivary glands in comparison to control animals. pre supplementation with t ... | 2008 | 23105792 |
| a study on the hypoglycemic and hypolipidemic effects of an ayurvedic drug rajanyamalakadi in diabetic patients. | a study was undertaken for evaluating the hypoglycemic and hypolipidemic effects of an ayurvedic medicine "rajanyamalakadi" containing curcuma longa, emblica officinalis and salacia oblonga in type ii diabetic patients over a period of 3 months. ethical committee consent for the study was given by the director, indian systems of medicine, kerala. a total of 43 patients with established diabetes mellitus as adjudged from clinical features and fbs values, appeared for the camp (age group 35-75 yrs ... | 2009 | 23105812 |
| effect of curcuma longa freeze dried rhizome powder with milk in stz induced diabetic rats. | this study deals with the effects of freeze dried rhizome powder of curcuma longa (c. longa) dissolved in milk on normal as well as diabetic models. diabetes of type ii and type i was within 3 days of a single administration of doses of 45 and 65 mg kg(-1) of streptozotocin respectively. various parameters such as blood glucose levels, triglycerides, total cholesterol, high density lipoprotein, very low density lipoprotein, low density lipoprotein, serum glutamic oxaloacetic transaminase, serum ... | 2010 | 23105906 |
| autophosphorylation activation and inhibition by curcumin of the epidermal growth factor receptor reconstituted in liposomes. | the epidermal growth factor receptor (egfr) is a 170-kda transmembrane protein with intrinsic protein kinase activity. it is involved in the regulation of essential cellular processes such as proliferation, differentiation, survival, and migration. an increase in egfr activity has been correlated to malignant evolution of the cells. we have used proteoliposomes as a platform to study the mechanism of activation and inhibition of egfr. we have been able to reconstitute functional egfr in liposome ... | 2012 | 23108622 |
| effect of curcumin on dexamethasone-induced testicular toxicity in mice. | curcumin is a yellow-orange polyphenol derived from turmeric [curcuma longa l. (zingiberaceaerhizomes)]. turmeric is a main ingredient of indian, persian, and thai dishes. extensive studies within the last half a century have demonstrated the protective action of curcumin in many disorders of the body. | 2013 | 23116244 |
| recent progress in studying curcumin and its nano-preparations for cancer therapy. | a hydrophobic polyphenol compound extracted from turmeric, curcumin has been widely utilized as traditional medicines for centuries in china and india. over the last decades, because of its low toxicity, extensive studies have been focused on its physicochemical properties and pharmacological activities on various diseases, such as cancer, cardio-vascular disease, inflammatory bowel, wound healing, alzheimer's disease, rheumatoid arthritis, and diabetes. in particular, bioactivities of curcumin ... | 2013 | 23116308 |
| curcumin nanomedicine: a road to cancer therapeutics. | cancer is the second leading cause of death in the united states. conventional therapies cause widespread systemic toxicity and lead to serious side effects which prohibit their long term use. additionally, in many circumstances tumor resistance and recurrence is commonly observed. therefore, there is an urgent need to identify suitable anticancer therapies that are highly precise with minimal side effects. curcumin is a natural polyphenol molecule derived from the curcuma longa plant which exhi ... | 2013 | 23116309 |
| the clinical applications of curcumin: current state and the future. | curcumin is a natural polyphenol product derived from the rhizome of the curcuma longa. in vivo and in vitro studies have uncovered many important bioactivities of curcumin, such as antioxidant activity, inducing cell apoptosis, inhibiting cell proliferation, anti-cell adhesion and motility, anti-angiogenesis and anti-microbe properties. based on these functions, curcumin has been used in clinical trials on various inflammatory diseases and cancers. in the future, it will be necessary to focus a ... | 2013 | 23116310 |
| a review of therapeutic effects of curcumin. | there is a growing interest in herbal medicine. scientific studies have demonstrated the beneficial pharmacological effects of curcumin. curcumin is a bright yellow spice, derived from the rhizome of curcuma longa linn. it has been proven that curcumin is a highly pleiotropic molecule which can be a modulator of intracellular signaling pathways that control cell growth, inflammation, and apoptosis. curcumin might be a potential candidate for the prevention and/or treatment of some diseases due t ... | 2013 | 23116311 |
| perspectives on new synthetic curcumin analogs and their potential anticancer properties. | curcumin is the active component of dried rhizome of curcuma longa, a perennial herb belonging to ginger family, cultivated extensively in south and southeastern tropical asia. it is widely consumed in the indian subcontinent, south asia and japan in traditional food recipes. extensive research over last few decades has shown that curcumin is a potent anti-inflammatory agent with powerful therapeutic potential against a variety of cancers. it suppresses proliferation and metastasis of human tumo ... | 2013 | 23116312 |
| delivery of curcumin and medicinal effects of the copper(ii)-curcumin complexes. | curcumin, a yellow pigment extracted from the rhizome of curcuma longa, commonly known as turmeric, is the most active agent of this herbal medicine. the therapeutic activities of curcumin are exemplified not only by its enhancement in wound healing but also in the treatment of inflammation, cystic fibrosis, alzheimer's disease and cancer. there are two critical issues involving low aqueous stability and solubility that limit the bioavailability and application of curcumin as a therapeutic agent ... | 2013 | 23116313 |
| curcumin: from chemistry to chemistry-based functions. | curcumin is a yellow pigment found in the spice turmeric and a main functional constituent of the rhizomes of curcuma longa. the multi-functionality of curcumin has recently attracted much attention in various fields, including food, medicinal, and clinical industries. three major curcuminoids, curcumin, demethoxycurcumin, and bis-demethoxycurcumin, are distributed in not only curcuma, but also the zingiber species; however, distribution of other curcuminoids is very limited in nature. the radic ... | 2013 | 23116314 |
| antioxidant and antiinflammatory activities of curcumin on diabetes mellitus and its complications. | diabetes mellitus (dm) has reached pandemic status and shows no signs of abatement. it can severely impair people's quality of life and affects patients all over the world. since it is a serious, chronic metabolic disease, it can bring about many kinds of complications, which can in turn increase mortality. in recent decades, more and more studies have shown that oxidative stress and inflammatory reactions play critical roles in the pathogenesis of dm. there is an increasing demand for natural a ... | 2013 | 23116316 |
| synthesis of quinoline derivatives of tetrahydrocurcumin and zingerone and evaluation of their antioxidant and antibacterial attributes. | tetrahydrocurcumin (thc, 1) and zingerone (2) are biologically active molecules originating from the important spices turmeric and ginger, respectively. novel quinoline derivatives of thc and zingerone have been synthesised by an efficient protocol involving their reaction with substituted 2-aminobenzophenones and 2-aminoacetophenone. radical-scavenging activities (rsa) of thc, zingerone and their quinoline derivatives were evaluated. the amino-substituted quinoline derivative of thc, 1e, showed ... | 2013 | 23122110 |
| inhibitory effect of the essential oil of curcuma longa l. and curcumin on aflatoxin production by aspergillus flavus link. | aflatoxins are highly toxic, mutagenic, teratogenic and carcinogenic mycotoxins. consumption of aflatoxin-contaminated food and commodities poses serious hazards to the health of humans and animals. turmeric, curcuma longa l., is a native plant of southeast asia and has antimicrobial, antioxidant and antifungal properties. this paper reports the antiaflatoxigenic activities of the essential oil of c. longa and curcumin. the medium tests were prepared with the oil of c. longa, and the curcumin st ... | 2013 | 23122128 |
| curcumin ameliorates diabetic nephropathy by inhibiting the activation of the sphk1-s1p signaling pathway. | curcumin, a major polyphenol from the golden spice curcuma longa commonly known as turmeric, has been recently discovered to have renoprotective effects on diabetic nephropathy (dn). however, the mechanisms underlying these effects remain unclear. we previously demonstrated that the sphingosine kinase 1-sphingosine 1-phosphate (sphk1-s1p) signaling pathway plays a pivotal role in the pathogenesis of dn. this study aims to investigate whether the renoprotective effects of curcumin on dn are assoc ... | 2013 | 23127801 |
| curcumin serves as a human kv1.3 blocker to inhibit effector memory t lymphocyte activities. | curcumin, the principal active component of turmeric, has long been used to treat various diseases in india and china. recent studies show that curcumin can serve as a therapeutic agent for autoimmune diseases via a variety of mechanisms. effector memory t cells (t(em), ccr7⁻ cd45ro⁺ t lymphocyte) have been demonstrated to play a crucial role in the pathogenesis of t cell-mediated autoimmune diseases, such as multiple sclerosis (ms) or rheumatoid arthritis (ra). kv1.3 channels are predominantly ... | 2013 | 23132777 |
| continuous exercise training and curcumin attenuate changes in brain-derived neurotrophic factor and oxidative stress induced by lead acetate in the hippocampus of male rats. | for many years it has been known that lead is life-threatening, not only as an air pollutant but also because of it has been associated with several conditions including neurodegenerative disease. curcumin (the principal curcuminoid found in turmeric) has demonstrated potent antioxidant properties. | 2013 | 23134146 |
| proniosomal formulation of curcumin having anti-inflammatory and anti-arthritic activity in different experimental animal models. | curcumin, the active ingredient of the spice turmeric, has a long history as an herbal remedy for a variety of diseases. transdermal drug delivery has been recognized as an alternative route to oral delivery. proniosomes offer a versatile vesicle delivery concept with the potential for drug delivery via the transdermal route. in this study, different proniosomal gel bases were prepared by the ether injection method, using span 60 and span 80, tween 20, cholesterol, and formulation pa2. they were ... | 2012 | 23136720 |
| ascorbic acid in cancer chemoprevention: translational perspectives and efficacy. | chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in multistage carcinogenesis has since decades attracted a considerable interest in plant-derived chemical constituents often termed as "phytochemicals" or sometimes as "nutraceuticals" in case they are derived from dietary sources. a comprehensive search of the literature show that such an interest in natural product pharmacology has surged in the last 25 years and particularly risen at expo ... | 2012 | 23140287 |
| chemopreventive and chemotherapeutic potential of curcumin in breast cancer. | breast cancer remains the leading cause of cancer death among females worldwide. it signifies a shift from the previous decade during which the most common cause of cancer death was cervical cancer. current treatment modalities, including surgery, radiotherapy, and adjuvant chemotherapy or hormone therapy, have not been successful enough to impart significant improvement in the morbidity or mortality of breast cancer. this cancer is highly resistant to chemotherapy as no effective treatment exis ... | 2012 | 23140290 |
| antidepressant-like effects of curcumin in wky rat model of depression is associated with an increase in hippocampal bdnf. | curcumin is the principal active ingredient found in turmeric (curcuma longa), a plant used in traditional asian diets and herbal medicines. it is known to have a wide range of biological actions including antidepressant-like effects which have been observed in stress-induced depression models. this study was designed to investigate the antidepressant potential of curcumin in a non-induced model of depression. moreover, since brain derived neurotrophic factor (bdnf) has been implicated in antide ... | 2013 | 23142609 |
| therapeutic roles of curcumin: lessons learned from clinical trials. | extensive research over the past half century has shown that curcumin (diferuloylmethane), a component of the golden spice turmeric (curcuma longa), can modulate multiple cell signaling pathways. extensive clinical trials over the past quarter century have addressed the pharmacokinetics, safety, and efficacy of this nutraceutical against numerous diseases in humans. some promising effects have been observed in patients with various pro-inflammatory diseases including cancer, cardiovascular disea ... | 2013 | 23143785 |
| evaluation of antioxidant, rheological, physical and sensorial properties of wheat flour dough and cake containing turmeric powder. | the effects of addition of turmeric powder (0%, 2%, 4%, 6% and 8%) were examined in order to obtain an antioxidant-enriched cake with good physico-chemical and sensorial properties. the rheological properties of doughs were evaluated using dynamic rheological measurements. physical properties, curcumin content, radical scavenging activity (rsa-dpph assay) and sensory analysis (hedonic test) of the supplemented cake were determined. addition of turmeric powder up to 8% caused significant changes ... | 2012 | 23144239 |
| the inhibitory effect of curcumin on voltage-dependent k⁺ channels in rabbit coronary arterial smooth muscle cells. | we investigated the effects of curcumin, the principal active compound of turmeric, on voltage-dependent k(+) (kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using the voltage-clamp technique. curcumin reduced the kv current in a dose-dependent manner with an apparent k(d) value of 1.07 ± 0.03 μm. although curcumin did not alter the kinetics of kv current activation, it predominantly accelerated the decay rate of channel inactivation. the association and dissociati ... | 2013 | 23146635 |
| curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. | vascular endothelial function is declines with aging and is associated with an increased risk of cardiovascular disease. lifestyle modification, particularly aerobic exercise and dietary adjustment, has a favorable effect on vascular aging. curcumin is a major component of turmeric with known anti-inflammatory and anti-oxidative effects. we investigated the effects of curcumin ingestion and aerobic exercise training on flow-mediated dilation as an indicator endothelial function in postmenopausal ... | 2012 | 23146777 |
| influence of red pepper spice and turmeric on inflammation and oxidative stress biomarkers in overweight females: a metabolomics approach. | red pepper spice (rp) and turmeric (tm) are used as flavorings in foods and for medicinal purposes. utilizing a randomized, doubled-blinded, placebo-controlled, crossover design (2-week washout), 4-week supplementation with rp (1 g/d) or tm (2.8 g/d) was tested for influences on inflammation and oxidative stress in 62 overweight/obese (body mass index ≥ 27 kg/m²) females (40-75 years) with systemic inflammation (c-reactive protein, crp ≥ 2 mg/l). overnight, fasted blood samples were collected pr ... | 2012 | 23150126 |
| knockdown of ki-67 by dicer-substrate small interfering rna sensitizes bladder cancer cells to curcumin-induced tumor inhibition. | transitional cell carcinoma (tcc) of the urinary bladder is the most common cancer of the urinary tract. most of the tcc cases are of the superficial type and are treated with transurethral resection (tur). however, the recurrence rate is high and the current treatments have the drawback of inducing strong systemic toxicity or cause painful cystitis. therefore, it would be of therapeutic value to develop novel concepts and identify novel drugs for the treatment of bladder cancer. ki-67 is a larg ... | 2012 | 23152782 |
| terpecurcumins a-i from the rhizomes of curcuma longa: absolute configuration and cytotoxic activity. | terpecurcumins a-i (1-9), together with three known analogues (10-12), were isolated from the rhizomes of curcuma longa (turmeric). they were derived from the hybridization of curcuminoids and bisabolanes. the structures and absolute configurations of 1-9 were elucidated on the basis of extensive spectroscopic data analysis, including nmr and electronic circular dichroism spectra. the configuration of 10 was further confirmed by x-ray crystallography. a plausible biogenetic relationship for 1-12 ... | 2012 | 23153397 |
| comparative evaluation of 0.1% turmeric mouthwash with 0.2% chlorhexidine gluconate in prevention of plaque and gingivitis: a clinical and microbiological study. | the aim of our clinical trial was to assess the efficacy of 0.1% turmeric mouthwash as an anti-plaque agent and its effect on gingival inflammation and to compare it with 0.2% chlorhexidine gluconate by evaluating the effect on plaque and gingival inflammation and on microbial load. | 2012 | 23162334 |
| modulating the vascular behavior of metastatic breast cancer cells by curcumin treatment. | the spreading of tumor cells to secondary sites (tumor metastasis) is a complex process that involves multiple, sequential steps. vascular adhesion and extravasation of circulating tumor cells (ctcs) is one, critical step. curcumin, a natural compound extracted from curcuma longa, is known to have anti-tumoral, anti-proliferative, anti-inflammatory properties and affect the expression of cell adhesion molecules, mostly by targeting the nf-κb transcription factor. here, upon treatment with curcum ... | 2012 | 23162792 |
| curcumin inhibits telomerase and induces telomere shortening and apoptosis in brain tumour cells. | curcumin, a polyphenolic compound isolated from curcuma longa (turmeric) is widely used in traditional ayurvedic medicine. its potential therapeutic effects on a variety of diseases have long been known. though anti-tumour effects of curcumin have been reported earlier, its mode of action and telomerase inhibitory effects are not clearly determined in brain tumour cells. in the present study, we demonstrate that curcumin binds to cell surface membrane and infiltrates into cytoplasm to initiate a ... | 2013 | 23192708 |
| the effects of a traditional drug, turmeric (curcuma longa), and placebo on the healing of duodenal ulcer. | in a joint vietnam-sweden prospective double-blind two-center study, the herbal remedy of curcuma longa (turmeric) - in a dosage of 6 g daily as suggested in the vietnamese pharmacopoeia - was compared with an equal amount of placebo in 118 patients, suffering from duodenal ulcer. the patients in the two groups were well matched prior to treatment. clinical assessments were carried out weekly, while laboratory investigations were carried out before beginning of the treatment and after four and e ... | 1998 | 23195696 |
| acute and subchronic toxicity as well as mutagenic evaluation of essential oil from turmeric (curcuma longa l). | the present study investigated the acute, subchronic and genotoxicity of turmeric essential oil (teo) from curcuma longa l. acute administration of teo was done as single dose up to 5 g of teo per kg body weight and subchronic toxicity study for thirteen weeks was done by daily oral administration of teo at doses 0.1, 0.25 and 0.5 g/kg b.wt. in wistar rats. there were no mortality, adverse clinical signs or changes in body weight; water and food consumption during acute as well as subchronic tox ... | 2013 | 23201370 |
| upregulation of phase ii enzymes through phytochemical activation of nrf2 protects cardiomyocytes against oxidant stress. | increased production of reactive oxygen species has been implicated in the pathogenesis of cardiovascular disease (cvd), and enhanced endogenous antioxidants have been proposed as a mechanism for regulating redox balance. nuclear factor (erythroid-derived 2)-like 2 (nrf2) is a transcriptional regulator of phase ii antioxidant enzymes, and activation of nrf2 has been suggested to be an important step in attenuating oxidative stress associated with cvd. a well-defined combination of five widely st ... | 2013 | 23201694 |
| curcumin inhibition of jnks prevents dopaminergic neuronal loss in a mouse model of parkinson's disease through suppressing mitochondria dysfunction. | curcumin,a natural polyphenol obtained from turmeric,has been implicated to be neuroprotective in a variety of neurodegenerative disorders although the mechanism remains poorly understood. the results of our recent experiments indicated that curcumin could protect dopaminergic neurons from apoptosis in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (mptp) mouse model of parkinson's disease (pd). the death of dopaminergic neurons and the loss of dopaminergic axon in the striatum were significantl ... | 2012 | 23210631 |
| screening of medicinal and edible plants in okinawa, japan, for enhanced proliferative and collagen synthesis activities in nb1rgb human skin fibroblast cells. | to identify plants with bioactive potential for skin care, methanol extracts of 56 plant parts from 47 medical and edible plants cultivated in okinawa were tested for their proliferative effects on nb1rgb skin fibroblast cells. extracts from six plants, bischofia javanica, colocasia esculenta, melaleuca alternifolia, piper angustifolia, jasminum sambac, and curcuma longa, showed higher nb1rgb cell proliferation activity (>10%) than the control, at various concentrations. among the six extracts, ... | 2012 | 23221723 |
| signaling pathways targeted by curcumin in acute and chronic injury: burns and photo-damaged skin. | phosphorylase kinase (phk) is a unique enzyme in which the spatial arrangements of the specificity determinants can be manipulated to allow the enzyme to recognize substrates of different specificities. in this way, phk is capable of transferring high energy phosphate bonds from atp to serine/threonine and tyrosine moieties in serine/threonine kinases and tyrosine kinases, thus playing a key role in the activation of multiple signaling pathways. phosphorylase kinase is released within five minut ... | 2013 | 23231506 |
| curcumin combined with turmerones, essential oil components of turmeric, abolishes inflammation-associated mouse colon carcinogenesis. | curcumin (cur), a yellow pigment in turmeric, has marked potential for preventing colon cancer. we recently reported that ar-turmerone (atm) suppressed nitric oxide (no) generation in macrophages. in the present study, we explored the molecular mechanisms by which atm attenuates no generation and examined the anti-carcinogenesis activity of turmerones (tur, a mixture of 5 sesquiterpenes including atm). both cur and atm inhibited lipopolysaccharide (lps)-induced expression of inducible forms of b ... | 2016 | 23233214 |
| prolonged biologically active colonic tissue levels of curcumin achieved after oral administration--a clinical pilot study including assessment of patient acceptability. | curcumin, the main constituent of turmeric, is suspected to possess cancer chemopreventive properties. pharmacokinetic and pharmacodynamic parameters have been reported, but few data exist describing whether methodologies are suitably robust for curcuminoid detection in colonic biopsy specimens. information on the acceptability of prolonged administration of daily curcumin is not available. this is of vital importance to implement chemoprevention strategies. this study aimed to quantify levels o ... | 2013 | 23233733 |
| why it is necessary to translate curcumin into clinical practice for the prevention and treatment of metabolic syndrome? | curcumin (diferuloylmethane) is the yellow-orange pigment of dried curcuma longa l. rhizomes (turmeric). during the past two decades, there has been a large volume of published studies describing the biological and pharmacological properties of this phytochemical including anticancer, anti-inflammatory, antioxidant, antithrombotic, antiatherosclerotic, cardioprotective, neuroprotective, memory enhancing, antiparkinsonism, antirheumatic, anti-infectious, antiaging, antipsoriatic, and anticonvulsa ... | 2013 | 23239418 |
| anti-uv activity of lignin-carbohydrate complex and related compounds. | we recently reported that an alkaline extract of the leaves of sasa senanensis rehder (se) and lentinus edodes mycelia extract (lem), exhibiting lignin-carbohydrate complex (lcc)-like activity, protected cells from uv-induced injury (referred to as anti-uv activity). we investigated whether lcc is the major active components responsible for anti-uv activity. | 2013 | 23239862 |
| safety and efficacy of curcuma longa extract in the treatment of painful knee osteoarthritis: a randomized placebo-controlled trial. | curcuma longa linn. is widely used for the treatment of disorders associated with inflammation and was evaluated for its safety and efficacy in the treatment of painful knee osteoarthritis (oa). this was a randomized, single blind, placebo-controlled trial. total of 120 patients (37 males and 83 females) with primary knee oa received either placebo (400 mg twice daily) or nr-inf-02 (500 mg twice daily) or glucosamine sulphate (gs) (750 mg twice daily) alone or combination of nr-inf-02 and gs for ... | 2013 | 23242572 |
| dehydrozingerone, a structural analogue of curcumin, induces cell-cycle arrest at the g2/m phase and accumulates intracellular ros in ht-29 human colon cancer cells. | dehydrozingerone (1) is a pungent constituent present in the rhizomes of ginger (zingiber officinale) and belongs structurally to the vanillyl ketone class. it is a representative of half the chemical structure of curcumin (2), which is an antioxidative yellow pigment obtained from the rhizomes of turmeric (curcuma longa). numerous studies have suggested that 2 is a promising phytochemical for the inhibition of malignant tumors, including colon cancer. on the other hand, there have been few stud ... | 2012 | 23245566 |
| the protective role of curcumin on perfluorooctane sulfonate-induced genotoxicity: single cell gel electrophoresis and micronucleus test. | perfluorooctane sulfonate (pfos) is a man-made fluorosurfactant and global pollutant. pfos a persistent and bioaccumulative compound, is widely distributed in humans and wildlife. therefore, it was added to annex b of the stockholm convention on persistent organic pollutants in may 2009. curcumin is a natural polyphenolic compound abundant in the rhizome of the perennial herb turmeric. it is commonly used as a dietary spice and coloring agent in cooking and anecdotally as an herb in traditional ... | 2013 | 23246701 |
| curcumin derivatives promote schwann cell differentiation and improve neuropathy in r98c cmt1b mice. | charcot-marie-tooth disease type 1b is caused by mutations in myelin protein zero. r98c mice, an authentic model of early onset charcot-marie-tooth disease type 1b, develop neuropathy in part because the misfolded mutant myelin protein zero is retained in the endoplasmic reticulum where it activates the unfolded protein response. because oral curcumin, a component of the spice turmeric, has been shown to relieve endoplasmic reticulum stress and decrease the activation of the unfolded protein res ... | 2012 | 23250879 |
| effects of curcumin on global gene expression profiles in the highly invasive human breast carcinoma cell line mda-mb 231: a gene network-based microarray analysis. | curcumin, or diferuloylmethane, is a major chemical component of turmeric (curcuma longa linn.) that has been consumed as a dietary spice through the ages. this yellow-colored polyphenol has a notably wide range of beneficial properties, including anti-inflammatory, antioxidant, antitumoral, anti-invasive and anti-metastatic activity. in the present study, microarray gene expression analysis was applied to identify the curcumin-regulated genes in a highly invasive human breast carcinoma cell lin ... | 2013 | 23251236 |
| oxidative metabolites of curcumin poison human type ii topoisomerases. | the polyphenol curcumin is the principal flavor and color component of the spice turmeric. beyond its culinary uses, curcumin is believed to positively impact human health and displays antioxidant, anti-inflammatory, antibacterial, and chemopreventive properties. it also is in clinical trials as an anticancer agent. in aqueous solution at physiological ph, curcumin undergoes spontaneous autoxidation that is enhanced by oxidizing agents. the reaction proceeds through a series of quinone methide a ... | 2013 | 23253398 |
| cardiovascular protection by curcumin: molecular aspects. | curcumin is the active component in turmeric--a spice that has been extensively used as a culinary agent and a home remedy to prevent and treat many diseases in india and other countries for hundreds of years. however, systematic studies to understand the molecular basis of disease preventing or therapeutic properties of curcumin began to appear in the scientific literature only during the last 40 years. as a result of these studies, substantial evidence has accumulated to suggest that curcumin ... | 2012 | 23259317 |
| inhibition of l-type ca(2+) channels by curcumin requires a novel protein kinase-theta isoform in rat hippocampal neurons. | curcumin, a major active compound of curcuma longa, has been reported to have potent neuroprotective activities. however to date, the relevant mechanisms still remain unclear. in this study, we report that curcumin selectively inhibits l-type ca(2+) channel currents in cultured rat hippocampal neurons. whole-cell currents were recorded using 10mm barium as a charge carrier. curcumin reversibly inhibited high-voltage-gated ca(2+) channel (hvgcc) currents (iba) in a concentration-dependent manner ... | 2013 | 23261315 |
| the toxicity and pathology of selected dietary herbal medicines. | toxicity studies were conducted by the national toxicology program (ntp) to provide information on the potential for toxicity from long-term use of commonly used herbal medicines. here, we review the findings from these ntp toxicology/carcinogenesis 2-year rodent studies of 7 commonly used herbs. in these studies, the individual herb or herbal product was administered to f344/n rats and b6c3f1 mice by oral administration for up to 2 years. the spectrum of carcinogenic responses ranged from no or ... | 2012 | 23262639 |
| development and validation of a real-time pcr method for the simultaneous detection of black mustard (brassica nigra) and brown mustard (brassica juncea) in food. | the paper presents a real-time pcr method allowing the simultaneous detection of traces of black mustard (brassica nigra) and brown mustard (brassica juncea) in food. the primers and the probe target the b. nigra partial rt gene for reverse transcriptase from gypsy-like retroelement 13g42-26. the real-time pcr method does not show any cross-reactivity with other brassicaceae species with the exception of white mustard. low cross-reactivities with cinnamon, cumin, fenugreek, ginger, rye and turme ... | 2012 | 23265498 |
| suites of terpene synthases explain differential terpenoid production in ginger and turmeric tissues. | the essential oils of ginger (zingiber officinale) and turmeric (curcuma longa) contain a large variety of terpenoids, some of which possess anticancer, antiulcer, and antioxidant properties. despite their importance, only four terpene synthases have been identified from the zingiberaceae family: (+)-germacrene d synthase and (s)-β-bisabolene synthase from ginger rhizome, and α-humulene synthase and β-eudesmol synthase from shampoo ginger (zingiber zerumbet) rhizome. we report the identification ... | 2012 | 23272109 |
| synthesis and biological evaluation of halogenated curcumin analogs as potential nuclear receptor selective agonists. | this report describes the synthesis of analogs of curcumin, and their analysis in acting as nuclear receptor specific agonists. curcumin (cm), a turmeric-derived bioactive polyphenol found in curry, has recently been identified as a ligand for the vitamin d receptor (vdr), and it is possible that cm exerts some of its bioeffects via direct binding to vdr and/or other proteins in the nuclear receptor superfamily. using mammalian-two-hybrid (m2h) and vitamin d responsive element (vdre) biological ... | 2013 | 23276449 |
| effects of curcumin on the parasite schistosoma mansoni: a transcriptomic approach. | schistosomiasis remains a severe problem of public health in developing countries. several reports show that praziquantel, the drug of choice for treating schistosomiasis, can select schistosoma mansoni strains resistant to the drug. thus, developing new drugs against this parasitosis is a highly desirable goal. curcumin, a phenolic compound deriving from the plant curcuma longa, has been shown to have anticancer, anti-inflammatory and antiparasitic effects. recently, our group has demonstrated ... | 2013 | 23276630 |
| curcumin in inflammatory diseases. | curcumin (diferuloylmethane), a yellow coloring agent extracted from turmeric is also used as a remedy for the treatment and prevention of inflammatory diseases. acute and chronic inflammation is a major factor in the progression of obesity, type ii diabetes, arthritis, pancreatitis, cardiovascular, neurodegenerative and metabolic diseases, as well as certain types of cancer. turmeric has a long history of use in ayurvedic medicine for the treatment of inflammatory disorders. recent studies on t ... | 2013 | 23281076 |
| incorporation of dimethoxycurcumin into charged liposomes and the formation kinetics of fractal aggregates of uncharged vectors. | dimethoxycurcumin (dmc) is a lipophilic analog of curcumin found in curcuma longa linn., which is known to possess significant activity against various cancer cell lines. the purpose of this study was to develop suitable liposomal formulations in order to overcome dmc's poor water solubility and to study the aggregation kinetic profile using the fractal analysis. dmc was incorporated into liposomal formulations composed of dppc, dppc:dppg:chol (9:1:1 molar ratio) and dppc:dodap:chol (9:1:1 molar ... | 2013 | 23294394 |
| boosting of nonspecific host response by aromatic spices turmeric and ginger in immunocompromised mice. | the present investigation was intended to study the immunostimulant properties of curcuma longa (turmeric) and zingiber officinale (ginger) rhizomes on splenic macrophages in carbon tetrachloride intoxicated male albino mice. the study was based on functional parameters like morphology, cell adhesion, phagocytosis, myeloperoxidase release, nitric oxide release and intracellular killing capacity of splenic macrophages. to elucidate the detailed mechanism of boosting of these cell functions, serum ... | 2012 | 23295981 |
| curcumin induces cell death and restores tamoxifen sensitivity in the antiestrogen-resistant breast cancer cell lines mcf-7/lcc2 and mcf-7/lcc9. | curcumin, a principal component of turmeric (curcuma longa), has potential therapeutic activities against breast cancer through multiple signaling pathways. increasing evidence indicates that curcumin reverses chemo-resistance and sensitizes cancer cells to chemotherapy and targeted therapy in breast cancer. to date, few studies have explored its potential antiproliferation effects and resistance reversal in antiestrogen-resistant breast cancer. in this study, we therefore investigated the effic ... | 2013 | 23299550 |
| curcumins-rich curry diet and pulmonary function in asian older adults. | research on the effects of dietary nutrients on respiratory health in human populations have not investigated curcumin, a potent anti-oxidant and anti-inflammatory compound present principally in turmeric used in large amounts in asian curry meals. | 2012 | 23300564 |
| cancer-linked targets modulated by curcumin. | in spite of major advances in oncology, the world health organization predicts that cancer incidence will double within the next two decades. although it is well understood that cancer is a hyperproliferative disorder mediated through dysregulation of multiple cell signaling pathways, most cancer drug development remains focused on modulation of specific targets, mostly one at a time, with agents referred to as "targeted therapies," "smart drugs," or "magic bullets." how many cancer targets ther ... | 2012 | 23301199 |
| molecular mechanisms of curcumin action: signal transduction. | chemoprevention represents one of the most highly effective anti-cancer strategies and is accompanied by minimal secondary effects as compared to conventional chemotherapies. many new anti-inflammatory and anti-cancer drug candidates have been derived from chemical scaffolds engineered from natural products discovered just a few decades ago. this approach is widely utilized in drug discovery in order to produce novel molecular entities with enhanced drug activities mediated through various signa ... | 2013 | 23303697 |
| curcumin in various cancers. | curcumin (diferuloylmethane), an active constituent of turmeric, is a well-described phytochemical, which has been used since ancient times for the treatment of various diseases. the dysregulation of cell signaling pathways by the gradual alteration of regulatory proteins is the root cause of cancers. curcumin modulates regulatory proteins through various molecular mechanisms. several research studies have provided in-depth analysis of multiple targets through which curcumin induces protective e ... | 2013 | 23303705 |
| skin regenerative potentials of curcumin. | curcumin, an active constituent of the spice turmeric, is well known for its chemopreventive properties and is found to be beneficial in treating various disorders including skin diseases. curcumin protects skin by quenching free radicals and reducing inflammation through the inhibition of nuclear factor-kappa b. curcumin also affects other signaling pathways including transforming growth factor-β and mitogen-activated protein kinase pathway. curcumin also modulates the phase ii detoxification e ... | 2013 | 23315856 |
| curcumin ameliorates the neurodegenerative pathology in a53t α-synuclein cell model of parkinson's disease through the downregulation of mtor/p70s6k signaling and the recovery of macroautophagy. | parkinson's disease (pd) is pathologically characterized by the presence of α-synuclein positive intracytoplasmic inclusions. the missense mutation, a53t α-synuclein is closely related to hereditary, early-onset pd. accumulating evidences suggest that pathological accumulation of a53t α-synuclein protein will perturb itself to be efficiently and normally degraded through its usual degradation pathway, macroautophagy-lysosome pathway, therefore toxic effects on the neuron will be exacerbated. bas ... | 2013 | 23325107 |
| curcumin and aging. | turmeric has been used commonly as a spice, food additive, and an herbal medicine worldwide. known as a bioactive polyphenolic extract of turmeric, curcumin has a broad range of health benefit properties for humans. recently, active research on curcumin with respect to aging and related traits in model organisms has demonstrated that curcumin and its metabolite, tetrahydrocurcumin (thc), increase mean lifespan of at least three model organisms: nematode roundworm, fruit fly drosophila, and mouse ... | 2013 | 23325575 |
| curcumin and genistein: the combined effects on disease-associated cftr mutants and their clinical implications. | genistein and curcumin are major components of asian foods, soybean and curry turmeric respectively. these compounds have been intensively investigated for their chemical and biological features conferring their anti-cancer activity. genistein and curcumin have also been investigated for their potentiation effects on disease-associated cftr mutants such as δf508 and g551d. recently, we investigated the combined effect of genistein and curcumin on g551d-cftr, which exhibits gating defects without ... | 2013 | 23331029 |
| complementary and alternative medicine use among mauritian women. | to assess cam usage among women in mauritius. | 2013 | 23337563 |
| molecular mechanisms of hypolipidemic effects of curcumin. | recent evidence suggests potential benefits from phytochemicals and micronutrients in reducing the elevated oxidative and lipid-mediated stress associated with inflammation, obesity, and atherosclerosis. these compounds may either directly scavenge reactive oxygen or nitrogen species or they may modulate the activity of signal transduction enzymes leading to changes in the expression of antioxidant genes. alternatively, they may reduce plasma lipid levels by modulating lipid metabolic genes in t ... | 2013 | 23339042 |
| curcumin and obesity. | turmeric has been long recognized for its anti-inflammatory and health-promoting properties. curcumin is one of the principal anti-inflammatory and healthful components of turmeric comprising 2-8% of most turmeric preparations. experimental evidence supports the activity of curcumin in promoting weight loss and reducing the incidence of obesity-related diseases. with the discovery that obesity is characterized by chronic low-grade metabolic inflammation, phytochemicals like curcumin which have a ... | 2013 | 23339049 |