Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| the association between deaths from myocardial infarction and household size in england and wales. | chronic infection with organisms such as chlamydia pneumoniae is thought to cause coronary heart disease. we investigated whether myocardial infarction deaths are associated with large household size and overcrowding, as these are factors that may facilitate the transmission of infection. | 2001 | 11455848 |
| chlamydia pneumonia seropositivity correlates with serum fibrinogen and lipoprotein a levels: any role in atherosclerosis? | the aim of the study is to determine the impact of chlamydial seropositivity on atherosclerosis in a group of patient requiring coronary and/or carotid revascularization. a population of 30 diabetic patients (group 3) and 26 nondiabetic patients (group 2) with angiographically documented coronary and/or carotid artery disease were enrolled for the study. volunteers from the relatives of hospital staff with no known disease (n=29; group 1) were included as the control group. serum samples from th ... | 2001 | 11456278 |
| chlamydophila (chlamydia) pneumoniae as a cause of community-acquired pneumonia in thailand. | chlamydophila (chlamydia) pneumoniae infection is increasingly reported worldwide nowadays. we studied twelve thai adults presenting with the clinical symptoms and signs of community-acquired pneumonia (cap) due to c. pneumoniae (twar) at pramongkutklao hospital in bangkok, thailand. their mean age was 38 (range 21-73) years. six patients lived in bangkok. seven patients had comorbid diseases (four cases with allergic asthma, one each with diabetes mellitus, chronic obstructive pulmonary disease ... | 2001 | 11460948 |
| chlamydia pneumoniae infection and its association with coronary heart disease and cardiovascular risk factors in a sample south asian population. | recent studies have suggested that a chronic infection with chlamydia pneumoniae (c. pneumoniae) may be associated with the risk of developing coronary heart disease (chd). a case control study was conducted to investigate the association between c. pneumoniae infection and coronary heart disease and coronary risk factors in a sample south asian population. c. pneumoniae specific igg antibody was measured by microimmunofluorescence. among controls 56.6% were seropositive (> or =1/32) compared to ... | 2001 | 11461741 |
| standardizing chlamydia pneumoniae assays: recommendations from the centers for disease control and prevention (usa) and the laboratory centre for disease control (canada). | chlamydia pneumoniae has been associated with atherosclerosis and several other chronic diseases, but reports from different laboratories are highly variable and "gold standards" are lacking, which has led to calls for more standardized approaches to diagnostic testing. using leading researchers in the field, we reviewed the available approaches to serological testing, culture, dna amplification, and tissue diagnostics to make specific recommendations. with regard to serological testing, only us ... | 2001 | 11462186 |
| a chlamydia pneumoniae-specific peptide induces experimental autoimmune encephalomyelitis in rats. | it has been reported recently that the bacterial respiratory pathogen chlamydia pneumoniae is present in the cerebrospinal fluid of a subset of multiple sclerosis (ms) patients. however, it is not known whether this organism is a causative agent of ms, or merely an opportunistic pathogen that takes advantage of a disease process initiated by some other means. we report identification of a 20-mer peptide from a protein specific to c. pneumoniae which shares a 7-aa motif with a critical epitope of ... | 2001 | 11466406 |
| inflammation, infection and antimicrobial therapy in coronary heart disease--where do we currently stand? | traditional atherosclerotic risk factors such as hypertension, smoking, hyperlipidaemia and diabetes mellitus, account for only about 50% of the clinical occurrence of coronary heart disease (chd). the infectious hypothesis proposes that various microorganisms, in particular, chlamydia pneumoniae, may serve as potential etiological factors, linking inflammation and atherosclerosis (or its clinical manifestations). evidence from seroepidemiology, pathology, animal models, molecular biology and im ... | 2001 | 11468018 |
| solid-phase amplification and detection: a single-tube diagnostic assay for infectious agents. | we report the development of an enzyme-linked immunosorbent assay-like single-tube assay for the detection of infectious agents in a microtiter tray format. | 2001 | 11468698 |
| temporal arteritis associated with chlamydia pneumoniae dna detected in an artery specimen. | 2001 | 11469491 | |
| comparative analysis of chlamydia bacteriophages reveals variation localized to a putative receptor binding domain. | three recently discovered ssdna chlamydia-infecting microviruses, phicpg1, phiar39, and chp2, were compared with the previously characterized phage from avian c. psittaci, chp1. although the four bacteriophages share an identical arrangement of their five main genes, chpl has diverged significantly in its nucleotide and protein sequences from the other three, which form a closely related group. the vp1 major viral capsid proteins of phicpg1 and phiar39 (from guinea pig-infecting c. psittaci and ... | 2000 | 11471835 |
| antibodies against chlamydia pneumoniae predict the need for elective surgical intervention on small abdominal aortic aneurysms. | to compare the ability of two independent chlamydia pneumoniae antibody tests to predict need for small abdominal aortic aneurysm (aaa) repair. | 2001 | 11472052 |
| chlamydia pneumoniae exposure and inflammatory markers in acute coronary syndrome (cimacs). | previous studies have shown higher levels of chlamydia pneumoniae (c. pneumoniae, cp) antibody titers (cpigg), c-reactive protein (crp), and fibrinogen in patients with coronary artery disease. the role of these infectious and inflammatory markers in precipitating acute coronary syndrome (acs) is unclear. we conducted a cross-sectional study on patients (n = 830, mean age 63 +/- 15 years, 57% male) admitted to the chest pain center of our institution. the differences in the cpigg, crp, and fibri ... | 2001 | 11472696 |
| introducing chlamydophila pneumoniae: the twar agent chlamydia pneumoniae in a new perspective. | 2001 | 11476910 | |
| bilateral pleural effusion and a subsegmental infiltrate due to chlamydia pneumoniae in a mechanically ventilated patient. | a case of chlamydia pneumoniae infection with bilateral pleural effusion and a subsegmental pulmonary infiltrate in an intubated and mechanically ventilated critically ill patient is described. diagnosis was made by polymerase chain reaction on both pleural effusions. | 2001 | 11476914 |
| low prevalence of chlamydia pneumoniae and mycoplasma pneumoniae among patients with symptoms of respiratory tract infections in dutch general practices. | acute respiratory disease is one of the most common reasons to consult a general practitioner. a substantial part of these diseases cannot be explained by an infection with a virus or a common pathogenic bacterium. to study this diagnostic deficit, the prevalence of chlamydia pneumoniae and mycoplasma pneumoniae infections was determined in two groups of patients consulting a general practitioner. dna of c. pneumoniae and m. pneumoniae was detected by a polymerase chain reaction (pcr) in nose/th ... | 2000 | 11484797 |
| chlamydia pneumoniae and chlamydial heat shock protein 60 stimulate proliferation of human vascular smooth muscle cells via toll-like receptor 4 and p44/p42 mitogen-activated protein kinase activation. | an early component of atherogenesis is abnormal vascular smooth muscle cell (vsmc) proliferation. the presence of chlamydia pneumoniae in many atherosclerotic lesions raises the possibility that this organism plays a causal role in atherogenesis. in this study, c pneumoniae elementary bodies (ebs) rapidly activated p44/p42 mitogen-activated protein kinases (mapks) and stimulated proliferation of vsmcs in vitro. exposure of vsmcs derived from human saphenous vein to c pneumoniae ebs (3x10(7) incl ... | 2001 | 11485974 |
| host immune response to chlamydia pneumoniae heat shock protein 60 is associated with asthma. | chlamydia pneumoniae infection has been associated with asthma. it has also been suggested that heat shock protein 60 (hsp60) belonging to a class of highly conserved proteins may play a role in the pathogenesis of chlamydial infections. the purpose was to study whether the host immune response to c. pneumoniae hsp60 is associated with asthma and decreased pulmonary function. an enzyme immunoassay was used to measure immunoglobulin-(ig)a and igg antibodies against recombinant c. pneumoniae hsp60 ... | 2001 | 11491147 |
| nonsevere community-acquired pneumonia: correlation between cause and severity or comorbidity. | community-acquired pneumonia frequently constitutes a nonsevere infection manageable at home. however, for these low-risk episodes, the epidemiological features have not been carefully analyzed. | 2001 | 11493128 |
| azithromycin chemoprophylaxis. | 2001 | 11494171 | |
| [a case presenting severe respiratory failure with high antibody titers to chlamydia pneumoniae]. | "hitazyme c. pneumoniae" is a diagnostic reagent that has been recently developed by adopting an elisa method for detection of anti-chlamydia pneumoniae (c. pneumoniae) antibodies. a case presenting bilateral interstitial opacities and severe respiratory failure with high titers of "hitazyme c. pneumoniae" was described. sputum, blood, serological, and bronchoalveolar lavage examinations failed to reveal other etiology to explain his severe respiratory illness. clinicians should be aware that c. ... | 2001 | 11494568 |
| discovering the dynamics of microbial genomes. | 2001 | 11494770 | |
| indicators of infection with chlamydia pneumoniae are associated with expansion of abdominal aortic aneurysms. | chlamydia pneumoniae has been shown to be associated with atherosclerosis, myocardial infarction, and abdominal aortic aneurysms (aaas). the possible association between aaa expansion and c pneumoniae infection was therefore assessed. | 2001 | 11496270 |
| chlamydia pneumoniae infection accelerates hyperlipidemia induced atherosclerotic lesion development in c57bl/6j mice. | considerable evidence of an association between chlamydia pneumoniae infections and cardiovascular disease has emerged. animal models using genetically altered mice and hypercholesterolemic rabbits have shown a pathogenic role of c. pneumoniae in accelerating atherosclerotic plaque development. in the present study, we evaluated the effect of chronic c. pneumoniae infection on atherosclerosis in c57bl/6j mice, fed either a regular chow diet or a high fat, high cholesterol diet. infected animals ... | 2001 | 11500169 |
| demonstration of chlamydia pneumoniae in atherosclerotic arteries from various vascular regions. | chlamydia pneumoniae (cp) has been reported to be a pathogenic agent in the mechanism leading to atherosclerosis. the majority of available data is focused mainly on coronary artery disease whereas the distribution of cp in different areas, associated with atherosclerotic disorders, has not been completely clarified. in this study we investigated the presence of cp in atheromasic plaques from five different vascular areas (basilary artery, coronary artery, thoracic aorta, abdominal aorta, renal ... | 2001 | 11500176 |
| chlamydia pneumoniae expresses genes required for dna replication but not cytokinesis during persistent infection of hep-2 cells. | chlamydia pneumoniae causes community-acquired pneumonia and is associated with several chronic diseases, including asthma and atherosclerosis. the intracellular growth rate of c. pneumoniae slows dramatically during chronic infection, and such persistence leads to attenuated production of new elementary bodies, appearance of morphologically aberrant reticulate bodies, and altered expression of several chlamydial genes. we used an in vitro system to further characterize persistent c. pneumoniae ... | 2001 | 11500413 |
| prevalence of chlamydia pneumoniae in acute respiratory tract infection and detection of anti-chlamydia pneumoniae-specific ige in japanese children with reactive airway disease. | we examined the prevalence of chlamydia pneumoniae in acute respiratory tract infection and association of c. pneumoniae infection and reactive airway disease in japanese children. four hundred eleven children with acute respiratory tract infection were enrolled in this study, and c. pneumoniae was isolated from 58 (14.1%) patients by culture. evidence of infection with c. pneumoniae was detected in 58 children with pneumonia (34.5%), bronchitis (41.4%) and upper respiratory tract infection (24. ... | 2001 | 11501498 |
| frequency of occurrence of cytomegalovirus and chlamydia pneumoniae in lymphocytes of atherosclerotic patients. | forty-three blood samples from atherosclerotic donors and 28 samples from normal individuals were analyzed to determine the frequency of occurrence of cytomegalovirus (cmv) and chlamydia pneumoniae dna sequences in lymphocytes of saudi arabian donors using polymerase chain reaction (pcr). in non-atherosclerotic donors, no cmv dna was detectable and only one sample was positive for c-pneumoniae dna sequences. of the 43 atherosclerotic patients, 22 were infected with cmv, 23 were infected with c-p ... | 2001 | 11503273 |
| [influence of chlamydia pneumoniae and cytomegalovirus infections on prevalence and the course of coronary artery disease]. | chlamydia pneumoniae (c. pneumoniae) as well as cytomegalovirus (cmv) are common pathogens found in about 50% of healthy western population. many studies suggest a role of c. pneumoniae in development of coronary artery disease (cad). cmv infection is also considered to increase risk of developing of cad as well as restenosis after percutaneous coronary revascularization (pci). the aim of our study was to evaluate a possible role of c. pneumoniae and cmv infections in both cad development and co ... | 2001 | 11505697 |
| chlamydial nucleic acids in synovium in osteoarthritis: what are the implications? | to study whether there is evidence of bacterial dna in some osteoarthritic (oa) joint tissues, and the clinical implications of finding bacterial dna in this relatively noninflammatory disease. | 2001 | 11508594 |
| [infection thesis as explanation of the higher incidence of myocardial infarction in males]. | 2001 | 11512289 | |
| [diseases from chlamydia psittaci and chlamydia pneumoniae]. | 2001 | 11515199 | |
| no evidence of cns infection with chlamydia pneumoniae in patients with multiple sclerosis. | 2001 | 11518005 | |
| clinical analysis of community-acquired pneumonia in the elderly. | to evaluate the clinical features, etiology, and outcome of patients over 65 years old hospitalized for community-acquired pneumonia. | 2001 | 11518106 |
| san-pin wang, md, mph, dmsc 1920-2001. | 2001 | 11518862 | |
| is chlamydia pneumoniae important in asthma? the first controlled trial of therapy leaves the question unanswered. | 2001 | 11520706 | |
| trial of roxithromycin in subjects with asthma and serological evidence of infection with chlamydia pneumoniae. | an association has been reported between chronic infection with chlamydia pneumoniae and the severity of asthma, and uncontrolled observations have suggested that treatment with antibiotics active against c. pneumoniae leads to an improvement in asthma control. we studied the effect of roxithromycin in subjects with asthma and immunoglobulin g (igg) antibodies to c. pneumoniae > or = 1:64 and/or iga antibodies > or = 1:16. a total of 232 subjects, from australia, new zealand, italy, or argentina ... | 2001 | 11520711 |
| [demonstration of chlamydophila pneumoniae and chlamydia stress protein, hsp-60 in heart muscle tissue]. | there has been much attention to the association between chlamydophila pneumoniae and athrosclerosis since c. pneumoniae was demonstrated in macropharges, and vascular smooth muscle cells of atheroma tissues. there are few data demonstrating whether c. pneumoniae is present in other tissues than atherosclerotic tissues. we surveyed samples of heart tissue from 10 patients with ischemic heart disease and 10 patients with other disease by immunohistochemical staining with monoclonal antibodies aga ... | 2001 | 11521279 |
| microbiological profile of telithromycin, the first ketolide antimicrobial. | telithromycin, the first of the ketolide antimicrobials, has been specifically designed to provide potent activity against common and atypical/intracellular or cell-associated respiratory pathogens, including those that are resistant to beta-lactams and/or macrolide-lincosamide-streptograminb (mls(b)) antimicrobials. against gram-positive cocci, telithromycin possesses more potent activity in vitro and in vivo than the macrolides clarithromycin and azithromycin. it retains its activity against e ... | 2001 | 11523558 |
| failure to detect chlamydia pneumoniae in the central nervous system of patients with ms. | 2001 | 11524506 | |
| antibodies to chlamydia pneumoniae in young swedish orienteers. | during 1992-93 sera from 1790 swedish elite orienteers were tested for antibodies to chlamydia pneumoniae. the reason for this was that a cluster of 16 cases of sudden unexpected cardiac death had occurred among swedish orienteers and dna from c. pneumoniae had been found in the myocarditic heart and in the lung in 1 of 2 deceased athletes in whom testing was feasible; in addition, c. pneumoniae igg was found in all 5 cases where serum was available. among the orienteers, the prevalence rates of ... | 2001 | 11525352 |
| effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with chlamydia pneumoniae infection. | this study was done to elucidate the effects of interleukin (il)-1 gene polymorphisms on coronary artery disease (cad) associated with chlamydia pneumoniae (cp) infection. | 2001 | 11527622 |
| seroprevalence of antibodies to microorganisms known to cause arterial and myocardial damage in patients with or without coronary stenosis. | infections are assumed to play a role in coronary artery disease (cad) and cardiomyopathies. it is unknown whether the seroprevalence of antibodies to these microorganisms is higher in patients with than without cad. the seroprevalence of antibodies to bartonella henselae, borrelia burgdorferi, chlamydia pneumoniae, coxiella burnetii, helicobacter pylori, human granulocytic ehrlichia, leptospira, rickettsia conorii, and treponema pallidum was assessed prospectively in patients with exertional dy ... | 2001 | 11527817 |
| sodium ion cycle in bacterial pathogens: evidence from cross-genome comparisons. | analysis of the bacterial genome sequences shows that many human and animal pathogens encode primary membrane na+ pumps, na+-transporting dicarboxylate decarboxylases or na+ translocating nadh:ubiquinone oxidoreductase, and a number of na+ -dependent permeases. this indicates that these bacteria can utilize na+ as a coupling ion instead of or in addition to the h+ cycle. this capability to use a na+ cycle might be an important virulence factor for such pathogens as vibrio cholerae, neisseria men ... | 2001 | 11528000 |
| randomized, placebo-controlled clinical trial of oral azithromycin prophylaxis against respiratory infections in a high-risk, young adult population. | military special forces trainees undergo intense psychological and physical stressors that often lead to respiratory infection. during 1998-2000, 477 navy special forces trainees were enrolled in a double-blind trial of oral azithromycin (1 g given weekly) plus a placebo injection, compared with benzathine penicillin g (1.2 million u) plus azithromycin placebo tablets. among the 464 subjects with complete data, 44 developed acute respiratory infection (20 with pneumonia) during the 2 weeks of mo ... | 2001 | 11528569 |
| in vitro activity of telithromycin, a new ketolide, against chlamydia pneumoniae. | the in vitro activity of telithromycin, a new ketolide, was compared with those of roxithromycin, azithromycin, clarithromycin and erythromycin a against 20 strains of chlamydia pneumoniae. the mics and minimal chlamydiacidal concentrations of telithromycin for the 20 c. pneumoniae strains both ranged between 0.031 and 0.25 mg/l. telithromycin was twice as active as roxithromycin, azithromycin and erythromycin a, but less active than clarithromycin. these results appear to indicate that telithro ... | 2001 | 11533006 |
| incidence of chlamydia pneumoniae infection in patients with coronary artery disease subjected to angioplasty or bypass surgery. | seroepidemiological, pathological and animal studies suggest that chronic infection with chlamydia pneumoniae (cp) may directly impact the development or progression of atherosclerosis and coronary heart disease. the aim of the present study was to determine the seroprevalence of cp infection and markers of systemic inflammation in patients undergoing routine coronary artery examination and prior to heart revascularization. | 2001 | 11535948 |
| predominant role of toll-like receptor 2 versus 4 in chlamydia pneumoniae-induced activation of dendritic cells. | chlamydia pneumoniae is an obligate intracellular human pathogen causing diseases such as pneumonia, bronchitis, and pharyngitis. because of its intracellular replication, cell-mediated immune responses are needed to mediate successful defenses of the host. because dendritic cells play a central role in linking innate immunity and ag-specific cell-mediated immune responses we asked whether dendritic cells are activated upon contact with c. pneumoniae and whether known toll like receptors (tlr) a ... | 2001 | 11544320 |
| chlamydia pneumoniae dna in the arterial wall of patients with peripheral vascular disease. | chlamydia pneumoniae is a human respiratory pathogen that has recently been related to the genesis of symptomatic atherosclerosis. c. pneumoniae has been studied more widely in relation to coronary atherosclerosis than to peripheral arterial occlusive disease (paod). the present study aimed to retrospectively analyze the presence of c. pneumoniae dna in patients with paod. | 2001 | 11545479 |
| increased cd8(+) t cells associated with chlamydia pneumoniae in symptomatic carotid plaque. | the presence of chlamydia pneumoniae has been reported in carotid atheroma, but its causative effect in the activation of an atherosclerotic plaque to a prothrombotic state remains unproved. antigen- mediated activation of t lymphocytes within plaque may represent a mechanism by which infection can result in plaque conversion. the goal of the present study was to characterize the t-cell subtype profile related to the presence of c pneumoniae in patients with symptomatic versus asymptomatic carot ... | 2001 | 11546882 |
| chlamydia pneumoniae in atherosclerotic middle cerebral artery. | atherosclerotic middle cerebral arteries are frequent sites of thrombosis, leading to stroke. previous studies have suggested a role for chlamydia pneumoniae in the pathogenesis of atherosclerosis. however, the presence of this pathogen in atherosclerotic middle cerebral arteries has heretofore not been documented. in the present study, we analyzed atheromatous plaques from middle cerebral arteries for the presence of c pneumoniae. | 2001 | 11546883 |
| newer risk factors for stroke. | stroke places a tremendous burden on health resources throughout the world. improved detection and modification of risk factors could reduce the impact of this disease. important non-modifiable risk factors for ischemic stroke include age, gender, ethnicity, and heredity. modifiable risk factors include hypertension, cardiovascular disease, diabetes, hyperlipidemia, asymptomatic carotid stenosis, cigarette smoking, and alcohol abuse. data from the northern manhattan stroke study provide new insi ... | 2001 | 11552052 |
| detection of chlamydia pneumoniae antigenin pbmncs of healthy blood donors. | because it has been increasingly recognized that chlamydia pneumoniae may be linked to some chronic inflammatory diseases, including atherosclerosis, detection of this pathogen in blood from patients may be valuable in the diagnosis of such diseases. however, the prevalence of chlamydia in the blood of healthy donors has not yet been extensively studied. | 2001 | 11552067 |
| non-detection of chlamydia species in carotid atheroma using generic primers by nested pcr in a population with a high prevalence of chlamydia pneumoniae antibody. | the association of chlamydia pneumoniae with atherosclerosis is controversial. we investigated the presence of c. pneumoniae and other chlamydia spp. in atheromatous carotid artery tissue. | 2001 | 11553320 |
| [presence of chlamydia pneumoniae antibodies in patients with ischemic heart disease and acute myocardial infarct]. | 2001 | 11554118 | |
| possible role of chlamydia and virus infections in the development of sexual dysfunction. | 2001 | 11554229 | |
| chlamydia pneumoniae, clarithromycin, and severe asthma. | 2001 | 11555549 | |
| advances in experimental dyslipidemia and atherosclerosis. | among the models of dyslipidemia and atherosclerosis, a number of wild-type, naturally defective, and genetically modified animals (rabbits, mice, pigeons, dogs, pigs, and monkeys) have been characterized. in particular, their similarities to and differences from humans in respect to relevant biochemical, physiologic, and pathologic conditions have been evaluated. features of atherosclerotic lesions and their specific relationship to plasma lipoprotein particles have been critically reviewed and ... | 2001 | 11555665 |
| microbiology. do chronic diseases have an infectious root? | 2001 | 11557857 | |
| labsystems enzyme immunoassay for chlamydia pneumoniae also detects chlamydia psittaci infections. | 2001 | 11558474 | |
| dilated cardiomyopathy and chlamydia pneumoniae infection. | 2001 | 11559690 | |
| laboratory diagnosis of respiratory diseases: pcr versus serology. | we present a comparison between serology and genetic detection of three bacterial pathogens causing lower respiratory tract infection (lri). we evaluated serology and pcr for the detection of mycoplasma pneumoniae, bordetella pertussis and chlamydia pneumoniae from 1712 nasopharyngeal and serum samples. for 856 nasopharyngeal samples, average pcr time was 7.2 days, the parallel serum samples was 13 days. automated extraction of nucleic acids reduces average pcr time to 6.7 days. | 2001 | 11562997 |
| oxidative processes in human promonocytic cells (thp-1) after differentiation into macrophages by incubation with chlamydia pneumoniae extracts. | human monocytes differentiated into macrophages by chlamydia pneumoniae were able to oxidize blood lipoproteins, as discovered by kalayoglu et al. (1998). using a model of human promonocytic cells (thp-1), the cells were differentiated into macrophages by preincubation with c. pneumoniae extract, and further stimulated by phorbol myristate acetate. in these conditions, the differentiated cells oxidized a thiol compound and released superoxide anion as demonstrated respectively by gas liquid chro ... | 2001 | 11563864 |
| recombination in the ompa gene but not the omcb gene of chlamydia contributes to serovar-specific differences in tissue tropism, immune surveillance, and persistence of the organism. | sequences of the major outer membrane protein (momp) gene (ompa) and the outer membrane complex b protein gene (omcb) from chlamydia trachomatis, chlamydia pneumoniae, and chlamydia psittaci were analyzed for evidence of intragenic recombination and for linkage equilibrium. the sawyer runs test, compatibility matrices, and index of association analyses provided substantial evidence that there has been a history of intragenic recombination at ompa including one instance of interspecies recombinat ... | 2001 | 11567000 |
| [the role of chlamydia pneumoniae in etiology of acute bronchitis in children]. | during examination of 60 children aged 3-15 years with manifestations of acute bronchitis chlamydia pneumoniae antigen was detected in their nasal and pharynx smears in 11.7% of cases with the use of enzyme immunoassay and indirect immunofluorescence test. in 10% of cases chlamydial pneumonia was diagnosed serologically. in the course of complex laboratory diagnostics c. pneumoniae was detected in 13.3% of cases. the most complete information could be obtained by a combination of different metho ... | 2001 | 11569265 |
| [pneumococcal and chlamydial infections in a closed community]. | an epidemic outbreak of acute respiratory infection (295 patients) in an organized group of young people was observed in december-may 1997-1998. pneumococcal etiology was established by means of indirect immunofluorescence reaction in cases of outpatient pneumonia (81.9%), acute bronchitis (80%) and acute respiratory diseases (92.5%). respiratory chlamydiosis caused by chlamydia pneumoniae was detected in enzyme immunoassay with the use of immunocomb chlamydia bivalent igg in patients with pneum ... | 2001 | 11569268 |
| prospective study of respiratory infections at the u.s. naval academy. | midshipmen at the u.s. naval academy have recently suffered epidemics of upper respiratory tract infections. seeking to determine cause, in june 1998 we enrolled 1,243 (99.5%) of 1,249 new midshipmen (plebes) and followed them during their first 11 months of training. eighty-five plebes sought medical attention for acute respiratory disease. using culture, serologic studies, and polymerase chain reaction, considerable evidence for respiratory pathogen infection was found among the ill subjects: ... | 2001 | 11569436 |
| development of enzyme immunoassays to detect salivary siga to chlamydia pneumoniae and mycoplasma pneumoniae. | enzyme immunoassays (eias) for the detection of secretory iga antibody (siga) to chlamydia pneumoniae and mycoplasma pneumoniae from saliva are described. the presence of salivary siga in healthy laboratory personnel (mean age 40, range 25-62 years) was detected using conjugates of antibodies directed against secretory and alpha-chain domains. the eia results for the detection of c pneumoniae siga antibodies were confirmed by a sensitive microimmunofluorescence method used as a reference. circul ... | 2001 | 11569482 |
| the significance of chlamydia pneumoniae in symptomatic carotid stenosis. | an association between symptomatic carotid stenosis and recent infection with chlamydia pneumoniae is reported. thirty-five patients (20 symptomatic and 15 asymptomatic) with carotid stenosis of 70% to 90% underwent carotid endarterectomy. endarterectomy was performed without patch and shunt; the average occlusion time of the internal carotid artery was 14 +/- 3 min. the atheromatic plaque and a portion of the thyroid artery were examined with polymerase chain reaction and peripheral vein blood ... | 2001 | 11570660 |
| mechanism of arterial infection by chlamydia pneumoniae. | 2001 | 11571261 | |
| [arteriosclerosis--an ultrachronic chlamydia infection]. | 2001 | 11571848 | |
| ultrastructural study of chlamydia pneumoniae in a continuous-infection model. | we have established an in vitro model of long-term continuous chlamydia pneumoniae infection in hep-2 cells. using transmission electron microscopy, we demonstrated the presence of spontaneous abnormal chlamydial inclusions similar in appearance to the persistent chlamydial forms induced in vitro by treatment with cytokines or antibiotics or by nutrient deprivation. | 2001 | 11574601 |
| effect of extended pre-incubation with chlamydia pneumoniae and extended incubation with antimicrobial on the minimum inhibitory concentrations (mics) of five antimicrobials. | there is no single standard methodology for in vitro susceptibility testing for chlamydia pneumoniae, but many investigators pre-incubate this organism with the cell monolayer for 1 h prior to adding antimicrobial and incubating for 72 h. the aim of this study was to determine the effect of extended c. pneumoniae pre-incubation, and extended incubation in the presence of antimicrobial, on the mics of 5 antimicrobials. mics were determined for 5 atcc strains of c. pneumoniae by employing similar ... | 2001 | 11576796 |
| chlamydia pneumoniae and cytomegalovirus seropositivity, inflammatory markers, and the risk of myocardial infarction at a young age. | pathogens causing chronic infections may promote atherosclerosis. the aim of our study was to evaluate the association of chlamydia pneumoniae (cp) and cytomegalovirus (cmv) infection and of inflammatory activation with premature myocardial infarction (mi). | 2001 | 11579353 |
| chlamydia pneumoniae-infected monocytes exhibit increased adherence to human aortic endothelial cells. | interactions between monocytes and endothelial cells play an important role in the pathogenesis of atherosclerosis, and monocyte adhesion to arterial endothelium is one of the earliest events in atherogenesis. work presented in this study examined human monocyte adherence to primary human aortic endothelial cells following monocyte infection with chlamydia pneumoniae, an intracellular pathogen associated with atherosclerosis by a variety of sero-epidemiological, pathological and functional studi ... | 2001 | 11580983 |
| infections of the central nervous system of suspected viral origin: a collaborative study from finland. | we studied 3231 patients with acute central nervous system (cns) symptoms of suspected viral origin to elucidate the current etiologic spectrum. in 46% of the cases, a viral finding was observed. varicella-zoster virus (vzv) was the main agent associated with encephalitis, as well as meningitis and myelitis. vzv comprised 29% of all confirmed or probable etiologic agents. herpes simplex virus (hsv) and enteroviruses accounted 11% each, and influenza a virus 7%. vzv seems to have achieved a major ... | 2001 | 11582512 |
| [severe infections in children with sickle cell disease: clinical aspects and prevention]. | sickle-cell disease (scd) is associated with frequent and often severe infections as a result of immune function impairment and functional asplenia. also, infection can trigger a vasoocclusive crisis. pneumonococcal bacteremia and meningitis due to s. pneumoniae are often lethal and justify the penicillin prophylaxis, which has provided a dramatic decrease in early mortality bacterial pneumonia is common in patients younger than four years, with most cases being due to s. pneumoniae, h. influenz ... | 2001 | 11582920 |
| antibiotic use and occlusive stroke: weighing a negative result. | 2001 | 11583648 | |
| differential expression of pmp10 in cell culture infected with chlamydia pneumoniae cwl029. | the complete genome of chlamydia pneumoniae contains a total of 21 genes encoding polymorphic membrane proteins (pmp). from this large pmp family three genes, pmp8, pmp10 and pmp11, were cloned and antibodies against recombinant full-length pmp proteins were produced. indirect immunofluorescence microscopy of hep-2 cells infected with c. pneumoniae cwl029 was performed with the pmp antibodies in combination with a chlamydia-specific anti-lipopolysaccharide (lps) antibody. this double staining te ... | 2001 | 11583841 |
| characterization of a hypervariable region in the genome of chlamydophila pneumoniae. | chlamydophila pneumoniae displays surprisingly little genomic variation, as seen by comparisons of the published genomes from three different isolates and sequencing of four different genes from different isolates. we have in the present study, however, demonstrated genomic variation between 10 c. pneumoniae isolates in the 11690-bp region between the two outer membrane protein genes pmp1 and pmp2. this region of the c. pneumoniae cwl-029 isolate contains seven c. pneumoniae-specific open readin ... | 2001 | 11583855 |
| c-reactive protein is increased in patients with degenerative aortic valvular stenosis. | the goal of this study was to assess the presence of systemic inflammation in degenerative aortic valvular stenosis. | 2001 | 11583885 |
| do pathogens accelerate atherosclerosis? | infection with the pathogens human cytomegalovirus (hcmv) or chlamydia pneumonia (cp) is linked to the development of vascular disease, including atherosclerosis. the role of pathogens in vasculopathies has been controversial. however, animal models have demonstrated a direct link between infection with cp and herpesviruses and the development of vascular disease. clinical studies have shown a direct association of hcmv and cp with the acceleration of vascular disease. this article will review t ... | 2001 | 11584110 |
| overview of infections and cardiovascular diseases. | microbes have been proposed as inciting agents of tissue injury and inflammation, both of which underlie the pathogenesis of atherosclerosis. viruses, including the herpes simplex virus and cytomegalovirus, as well as bacteria such as chlamydia pneumoniae, have been implicated in the process. in vitro, these agents promote a proinflammatory and a procoagulant phenotype in vascular cells. viruses augment cell accumulation through alterations of apoptosis. infectious agents may play a role in path ... | 2001 | 11586278 |
| association between infection with helicobacter pylori and chlamydia pneumoniae and risk of ischemic stroke subtypes: results from a population-based case-control study. | helicobacter pylori and chlamydia pneumoniae have been associated epidemiologically and pathogenetically with coronary atherosclerosis. however, population-based data on chronic infection and stroke are lacking. therefore, we investigated the association of both bacterial pathogens and ischemic stroke subtypes in a population-based case-control study. | 2001 | 11588309 |
| re: chlamydia pneumoniae does not influence atherosclerotic plaque behavior in patients with established carotid artery stenosis. | 2001 | 11588345 | |
| association between sézary t cell-activating factor, chlamydia pneumoniae, and cutaneous t cell lymphoma. | sézary t cell-activating factor (saf) was originally defined as an inducer of functional interleukin-2 (il-2) receptors on normal and malignant t cells in patients suffering from sézary syndrome. in fact, a combination of saf and il-2 stimulated the propagation of t cell lines from the peripheral blood mononuclear cells (pbmc) of those patients, with approximately one third of those cell lines containing the predominant malignant clone as determined via cytogenetic and/or t cell receptor gene re ... | 2001 | 11594584 |
| survival of chlamydia pneumoniae-infected mono mac 6 cells is dependent on nf-kappab binding activity. | the respiratory tract pathogen chlamydia pneumoniae has been associated with atherosclerosis. monocytes are supposed to serve as a vehicle for systemic dissemination of intracellular c. pneumoniae from the lung to the artery vessel wall. we were therefore interested in pathogen-induced cellular events associated with nf-kappab, a crucial transcription factor for both inflammatory cytokines and antiapoptotic molecules. in this study we demonstrate by electrophoretic mobility shift assay that c. p ... | 2001 | 11598079 |
| characterization of antiapoptotic activities of chlamydia pneumoniae in human cells. | chlamydia pneumoniae is an obligate intracellular bacterium which frequently causes airway infection in humans and has been implicated in atherosclerosis. here we show that infection with c. pneumoniae protects hela human epithelioid cells against apoptosis induced by external stimuli. in infected hela cells, apoptosis induced by staurosporine and cd95-death-receptor signaling was strongly reduced. upon treatment with staurosporine, generation of effector caspase activity, processing of caspase- ... | 2001 | 11598088 |
| chlamydia pneumoniae infection and acute exacerbation of chronic obstructive pulmonary disease (copd). | the objective of the study was to investigate the possible association of chlamydia pneumoniae (cpn) in acute exacerbations of chronic obstructive pulmonary disease (copd) patients. thirty-eight acutely exacerbated copd patients and 17 healthy smokers were enrolled in the study, as the study and control groups respectively. nasopharyngeal swabs and paired serum samples for antibody testing of cpn (microimmunofluorescence--mif) were obtained from all subjects. sputum cultures of copd patients wer ... | 2001 | 11601747 |
| [analysis of occurrence of chlamydophila pneumoniae infection serological markers in patients with bronchial asthma]. | numerous publications pointing the role of chlamydophila pneumoniae infections in etiopathogenesis of bronchial asthma have appeared in recent years. up to the presence the diagnostics of chlamydophila pneumoniae infections has been based on the serological examinations especially on indirect microimmunofluorescence which is regarded to be a "gold standard". the aim of the paper was to compare the occurrence of chlamydophila pneumoniae infection serological markers in the group of patients with ... | 2001 | 11641895 |
| atypical pathogens and asthma: can they influence the natural history of the disease? | the association between respiratory infections and asthma exacerbations was first observed in the early '70s. in particular, the role of viral upper respiratory tract infections has been evaluated both in pediatric and adult populations. more recently, evidence of mycoplasma and chlamydia pneumoniae involvement in asthma attacks has been reported. these pathogens are also involved in chronic asthma, and both in vitro and animal model studies indicate that atypical agents may play a role in the p ... | 2001 | 11665510 |
| acute-phase proteins and chlamydia pneumoniae infection: which one is more important in acute coronary syndrome? | elevated levels of acute-phase proteins, a systemic marker for inflammation, predict coronary events; chlamydia pneumoniae (c. pneumoniae) infection is associated with coronary atherosclerosis. the present study investigated whether inflammation or infection is involved in the pathogenesis of acute coronary syndrome (acs) and which one has the more important role. the study group comprised 49 patients with angiographically diagnosed acs, 48 cases of chronic coronary heart disease (cchd), and 44 ... | 2001 | 11665787 |
| use of doxycycline to decrease the growth rate of abdominal aortic aneurysms: a randomized, double-blind, placebo-controlled pilot study. | eradication of chlamydia pneumoniae infection and inhibition of elastolytic matrix metalloproteinases with doxycycline have been suggested to reduce the growth rates of small abdominal aortic aneurysms (aaa). we designed a study to investigate the efficacy of doxycycline in reducing the expansion of small aaas. | 2001 | 11668312 |
| the differential killing of genes by inversions in prokaryotic genomes. | we have elaborated a method which has allowed us to estimate the direction of translocation of orthologs which have changed, during the phylogeny, their positions on chromosome in respect to the leading or lagging role of dna strands. we have shown that the relative number of translocations which have switched positions of genes from the leading to the lagging dna strand is lower than the number of translocations which have transferred genes from the lagging strand to the leading strand of proka ... | 2001 | 11677621 |
| the role of atypical pathogens in community-acquired pneumonia. | the atypical pathogens in community-acquired pneumonia traditionally have included mycoplasma pneumoniae, chlamydia pneumoniae, and legionella spp. recent studies documenting their epidemiology and clinical characteristics have shown that these organisms are indistinguishable from the pneumococcus. furthermore, therapy no longer depends on the specific bacterial cause of community-acquired pneumonia. etiologic diagnosis is still difficult, although new methods are becoming available. this articl ... | 2001 | 11680106 |
| application of blood-based polymerase chain reaction for detection of chlamydia pneumoniae in acute respiratory tract infections. | the aim of this study was to investigate whether blood-based polymerase chain reaction could serve as a diagnostic tool to identify individuals with acute respiratory chlamydia pneumoniae infection. respiratory specimens and peripheral blood mononuclear cells of 58 patients were analyzed using nested polymerase chain reaction and cell culture. fifteen patients were polymerase chain reaction-positive for chlamydia pneumoniae. nine patients were positive in only the respiratory specimen; two in bo ... | 2001 | 11681441 |
| chlamydia trachomatis serology: diagnostic value of outer membrane protein 2 compared with that of other antigens. | different immunoassays using recombinant antigens or synthetic peptides were evaluated for the serodiagnosis of chlamydia trachomatis infections. antigens used included cysteine-rich outer membrane protein 2 (omp2), heat shock protein 60, the polypeptide encoded by open reading frame 3 of the plasmid (pgp3), synthetic peptides derived from species-specific epitopes in variable domain iv of the major omp (momp) (labsystems, helsinki, finland), and a fragment of the total lipopolysaccharide (medac ... | 2001 | 11682533 |
| [etiology of chronic cough in children: analysis of 100 cases]. | in order to understand the epidemiological aspects of chronic cough, we analysed 100 patients' files referred for chronic cough in five pediatric-pulmonology consultations. the patients had a chronic cough for more than 3 weeks. the distribution of causes was: asthma, 56%; upper airway disorders, 16%; psychogenic, 4%; whooping cough, 4%; mycoplasma pneumoniae pulmonary infection, 3%; chlamydia pneumoniae pulmonary infection, 1%; bronchiectasis, 1%. in 15% of cases two or more causes were associa ... | 2001 | 11683089 |
| evaluation of chlamydia pneumoniae 43- and 53-kilodalton recombinant proteins for serodiagnosis by western blot. | chlamydia pneumoniae is a common cause of respiratory infection. it has also been shown to be associated with coronary heart disease. two proteins that have been reported to be recognized frequently during human infection are proteins having molecular masses of 43 and 53 kda. in order to develop a useful alternative serological test to the microimmunofluorescence (micro-if) assay, recombinant 43-kda and 53-kda chlamydia-specific proteins were evaluated in dot blot and/or for comparison to the st ... | 2001 | 11687468 |
| chlamydia pneumoniae exacerbates aortic inflammatory foci caused by murine cytomegalovirus infection in normocholesterolemic mice. | inflammatory foci induced by murine cytomegalovirus infection in normocholesterolemic mice were present temporarily in the aortic wall, but some of these foci developed into advanced lesions that persisted late after infection. the early foci induced by virus infection were significantly exacerbated following a single inoculation with chlamydia pneumoniae. | 2001 | 11687473 |
| [multiple sclerosis. chlamydia hypothesis in debate]. | recently, an association between multiple sclerosis and chlamydia pneumoniae infection has been suggested. because standardized pcr protocols are lacking, a series of studies could not clarify whether c. pneumoniae is present in brain tissue and csf of ms patients. therefore, other studies focused on the humoral immune response against c. pneumoniae: 24% of ms patients, but only 5% of the control patients showed intrathecally produced antibodies against c. pneumoniae. if an infection with c. pne ... | 2001 | 11688186 |