Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| phylodynamic analysis of the canine distemper virus hemagglutinin gene. | canine distemper (cd) is one of the most contagious and lethal viral diseases in dogs. despite the widespread use of vaccines, the prevalence of the cd virus (cdv) has increased at an alarming rate in recent years. in this phylodynamic study, we investigated the spatiotemporal modes of dispersal, viral demographic trends, and effectiveness of vaccines for cdv. a total of 188 full-length cdv hemagglutinin (h) gene sequences dataset were subjected to recombination analysis, including seven from mo ... | 2015 | 26205391 |
| pathogenesis of canine distemper virus in experimentally infected raccoon dogs, foxes, and minks. | canine distemper virus (cdv) infects a broad range of carnivores and causes a highly contagious disease with severe immunosuppression. the disease severity markedly varies in different species. to investigate the pathogenesis of cdv in raccoon dog (nyctereutes procyonoides), fox (vulpes vulpes) and mink (neovison vison) species, three groups of cdv sero-negative animals were infected with cdv strain ln(10)1. this cdv strain belongs to the asia-1 genotype, which is epidemiologically predominant i ... | 2015 | 26210812 |
| isolation and sequence analysis of a canine distemper virus from a raccoon dog in jilin province, china. | canine distemper virus (cdv) is a major pathogen not only in raccoon dogs but also in a variety of carnivorous animals, including domesticated animals, particularly if they have not been vaccinated. in this study, a wild-type strain of cdv was isolated from lung tissue from a raccoon dog kept at a fur farm in jilin province, china. cytopathic effects typical of cdv infection were observed after three blind passages in vero cells, yielding a virus titer of 10(4.6) tcid50/ml. virus identification ... | 2015 | 26265248 |
| concomitance and interactions of pathogens in the iberian wolf (canis lupus). | with the aim of improving our understanding of their epidemiological features, exposure to or presence of canine parvovirus (cpv), canine distemper virus (cdv), leishmania infantum and sarcoptes scabiei were studied in 88 wild wolves from asturias (northern spain) by means of long-term (2004-2010) serological and molecular data. individual and population factors and the possible interactions between them were also statistically analyzed for better understanding the contact/presence of studied pa ... | 2015 | 26267084 |
| preparation and identification of a single-chain variable fragment antibody against canine distemper virus. | the variable regions of the heavy chain (vh) and light chain (vl) were amplified by rt-pcr from the hybridoma 1n8, which secretes the monoclonal antibody against cdv n protein (aa 277-471). the vl and vh amplicons were combined using soe-pcr by a 12 amino acid flexible linker (ssggggsggggs), which produced the scfv gene (named scfv/1n8). after sequence analysis, the scfv/1n8 gene was cloned into the prokaryotic expression vector pet32a with a his-tag. the recombinant scfv/1n8 protein was success ... | 2015 | 26301925 |
| blindness in a wild american black bear cub (ursus americanus). | an approximately six-month-old wild american black bear (ursus americanus) was found wandering in saskatchewan and was presented to the veterinary medical centre of the western college of veterinary medicine for apparent blindness. clinical examination confirmed an inability to navigate a photopic maze, bilateral tapetal hyper-reflectivity, fundi devoid of retinal vessels, and small pale optic nerve papillae. single-flash electroretinography revealed a and b-wave amplitudes of approximately 40 a ... | 2016 | 26302466 |
| use of serologic tests to predict resistance to canine distemper virus-induced disease in vaccinated dogs. | the objective of the current study was to determine whether detection of canine distemper virus (cdv)-specific serum antibodies correlates with resistance to challenge with virulent virus. virus neutralization (vn) assay results were compared with resistance to viral challenge in 2 unvaccinated beagle puppies, 9 unvaccinated beagle dogs (4.4-7.2 years of age), and 9 vaccinated beagle dogs (3.7-4.7 years of age). eight of 9 (89%) unvaccinated adult dogs exhibited clinical signs after virus challe ... | 2015 | 26330396 |
| tumour necrosis factor-alpha-induced protein 8 (tnfaip8) expression associated with cell survival and death in cancer cell lines infected with canine distemper virus. | oncolytic virotherapy is a novel strategy for treatment of cancer in humans and companion animals as well. canine distemper virus (cdv), a paramyxovirus, has proven to be oncolytic through induction of apoptosis in canine-derived tumour cells, yet the mechanism behind this inhibitory action is poorly understood. in this study, three human mammary tumour cell lines and one canine-derived adenofibrosarcoma cell line were tested regarding to their susceptibility to cdv infection, cell proliferation ... | 2015 | 26373887 |
| unusual necrotizing encephalitis in raccoons and skunks concurrently infected with canine distemper virus and sarcocystis sp. | canine distemper virus commonly infects free-ranging, terrestrial mesopredators throughout the united states. due to the immunosuppressive effects of the virus, concurrent opportunistic infections are also common. among these, secondary systemic protozoal infections have been described in a number of species. we report an unusual presentation of necrotizing encephalitis associated withsarcocystissp in four raccoons and one skunk concurrently infected with canine distemper virus. lesions were cha ... | 2016 | 26374278 |
| isolation and phylogenetic characterization of canine distemper virus from india. | canine distemper (cd), caused by canine distemper virus (cdv) is a highly contagious disease that infects a variety of carnivores. sequence analysis of cdvs from different geographical areas has shown a lot of variation in the genome of the virus especially in haemagglutinin gene which might be one of the causes of vaccine failure. in this study, we isolated the virus (place: ludhiana, punjab; year: 2014) and further cloned, sequenced and analyzed partial haemagglutinin (h) gene and full length ... | 2015 | 26396979 |
| associations between biosecurity and outbreaks of canine distemper on danish mink farms in 2012-2013. | during 8 months from july 2012 to february 2013, a major outbreak of canine distemper involving 64 mink farms occurred on the danish peninsula of jutland. the canine distemper outbreak was associated with exposure of farmed mink to infected wild carnivores and could represent a deficit in biosecurity on the mink farms. the aim of this study was to investigate the extent and association of specific biosecurity measures with the outbreak. the study was carried out in an epidemiological case-contro ... | 2015 | 26423523 |
| characteristics of a canine distemper virus outbreak in dichato, chile following the february 2010 earthquake. | following the earthquake and tsunami disaster in chile in february 2010, residents of dichato reported high morbidity and mortality in dogs, descriptions of which resembled canine distemper virus (cdv). to assess the situation, free vaccine clinics were offered in april and may. owner information, dog history and signalment were gathered; dogs received physical examinations and vaccines protecting against cdv, and other common canine pathogens. blood was collected to screen for igm antibodies to ... | 2013 | 26479537 |
| specific detection of peste des petits ruminants virus antibodies in sheep and goat sera by the luciferase immunoprecipitation system. | peste des petits ruminants (ppr) is a contagious and often fatal transboundary animal disease affecting mostly sheep, goats and wild small ruminants. this disease is endemic in most of africa, the middle, near east, and large parts of asia. the causal agent is peste des petits ruminants virus (pprv), which belongs to the genus morbillivirus in the family paramyxoviridae. this genus also includes measles virus (mv), canine distemper virus (cdv) and rinderpest virus (rpv). all are closely related ... | 2016 | 26506137 |
| identification of a novel canine distemper virus b-cell epitope using a monoclonal antibody against nucleocapsid protein. | canine distemper virus (cdv) is a member of the genus morbillivirus within the family paramyxoviridae and has caused severe economic losses in china. nucleocapsid protein (n) is the major structural viral protein and can be used to diagnose cdv and other morbilliviruses. in this study, a specific monoclonal antibody, 1n8, was produced against the cdv n protein (amino acids 277-471). a linear n protein epitope was identified by subjecting a series of partially overlapping synthesized peptides to ... | 2016 | 26514066 |
| low titers of canine distemper virus antibody in wild fishers (martes pennanti) in the eastern usa. | canine distemper virus (cdv) infects species in the order carnivora. members of the family mustelidae are among the species most susceptible to cdv and have a high mortality rate after infection. assessing an animal's pathogen or disease load prior to any reintroduction project is important to help protect the animal being reintroduced, as well as the wildlife and livestock in the area of relocation. we screened 58 fishers for cdv antibody prior to their release into pennsylvania, us, as part of ... | 2016 | 26555109 |
| patterns of exposure of iberian wolves (canis lupus) to canine viruses in human-dominated landscapes. | wildlife inhabiting human-dominated landscapes is at risk of pathogen spill-over from domestic species. with the aim of gaining knowledge in the dynamics of viral infections in iberian wolves (canis lupus) living in anthropized landscapes of northern spain, we analysed between 2010 and 2013 the samples of 54 wolves by serology and polymerase chain reaction (pcr) for exposure to four pathogenic canine viruses: canine distemper virus (cdv), canine parvovirus-2 (cpv), canine adenovirus 1 and 2 (cav ... | 2016 | 26589403 |
| canine distemper virus fusion activation: critical role of residue e123 of cd150/slam. | measles virus (mev) and canine distemper virus (cdv) possess tetrameric attachment proteins (h) and trimeric fusion proteins, which cooperate with either slam or nectin 4 receptors to trigger membrane fusion for cell entry. while the mev h-slam cocrystal structure revealed the binding interface, two distinct oligomeric h assemblies were also determined. in one of the conformations, two slam units were sandwiched between two discrete h head domains, thus spotlighting two binding interfaces ("fron ... | 2015 | 26608324 |
| utility of two modified-live virus canine distemper vaccines in wild-caught fishers (martes pennanti). | canine distemper virus (cdv) infects families in the order carnivora. as a preventive measure, vaccinations against cdv are frequently given to mustelids in captive environments. | 2016 | 26610027 |
| rt-pcr and sequence analysis of the full-length fusion protein of canine distemper virus from domestic dogs. | during 2007-2014, 84 out of 236 (35.6%) samples from domestic dogs submitted to our laboratory for diagnostic purposes were positive for canine distemper virus (cdv), as analyzed by rt-pcr amplification of a fragment of the nucleoprotein gene. fifty-nine of them (70.2%) were from dogs that had been vaccinated against cdv. the full-length gene encoding the fusion (f) protein of fifteen isolates was sequenced and compared with that of those of other cdvs, including wild-type and vaccine strains. p ... | 2016 | 26611227 |
| sequencing of emerging canine distemper virus strain reveals new distinct genetic lineage in the united states associated with disease in wildlife and domestic canine populations. | recent outbreaks of canine distemper have prompted examination of strains from clinical samples submitted to the university of tennessee college of veterinary medicine (utcvm) clinical virology lab. we previously described a new strain of cdv that significantly diverged from all genotypes reported to date including america 2, the genotype proposed to be the main lineage currently circulating in the us. the aim of this study was to determine when this new strain appeared and how widespread it is ... | 2015 | 26683832 |
| adenovirus 2, bordetella bronchiseptica, and parainfluenza molecular diagnostic assay results in puppies after vaccination with modified live vaccines. | canine adenovirus 2, parainfluenza, and bordetella bronchiseptica cause respiratory disease in dogs, and each has a modified live intranasal vaccine available. molecular diagnostic assays to amplify specific nucleic acids are available for each of these agents. if positive molecular diagnostic assay results are common after vaccination, the positive predictive value of the diagnostic assays for disease would be decreased. | 2015 | 26692461 |
| dog overpopulation and burden of exposure to canine distemper virus and other pathogens on santa cruz island, galapagos. | dog overpopulation and diseases are hazards to native island species and humans on the galapagos. vaccination and importation of dogs are prohibited on the galapagos. risk management of these hazards requires the use of science-based risk assessment and risk communication. the objectives of the study reported here were (i) to estimate the human:dog ratio and (ii) the prevalence of and identify exposure factors associated with positive antibody titers to canine distemper virus (cdv) and other pat ... | 2016 | 26700426 |
| efficient generation of vesicular stomatitis virus (vsv)-pseudotypes bearing morbilliviral glycoproteins and their use in quantifying virus neutralising antibodies. | morbillivirus neutralising antibodies are traditionally measured using either plaque reduction neutralisation tests (prnts) or live virus microneutralisation tests (micro-nts). while both test formats provide a reliable assessment of the strength and specificity of the humoral response, they are restricted by the limited number of viral strains that can be studied and often present significant biological safety concerns to the operator. in this study, we describe the adaptation of a replication- ... | 2016 | 26706278 |
| phocine distemper virus (pdv) seroprevalence as predictor for future outbreaks in harbour seals. | phocine distemper virus (pdv) infections caused the two most pronounced mass mortalities in marine mammals documented in the past century. during the two outbreaks, 23,000 and 30,000 harbour seals (phoca vitulina), died in 1988/1989 and 2002 across populations in the wadden sea and adjacent waters, respectively. to follow the mechanism and development of disease spreading, the dynamics of morbillivirus-specific antibodies in harbour seal populations in german and danish waters were examined. 522 ... | 2016 | 26790934 |
| fatal nocardiosis in a dog caused by multiresistant nocardia veterana. | among pathogenic nocardia species in humans and animals, infections caused by nocardia (n.) veterana have rarely been described and so far, all non-human cases are linked to bovine mastitis in brazil. the aim of this study was to identify the causative microorganism involved in the death of a three-month-old dog suffering from dyspnea and neurological deficits ante mortem. pathomorphological investigation revealed (pyo-)granulomatous lesions in various organs. bacteriological examination was per ... | 2016 | 26790938 |
| morbillivirus and henipavirus attachment protein cytoplasmic domains differently affect protein expression, fusion support and particle assembly. | the amino-terminal cytoplasmic domains of paramyxovirus attachment glycoproteins include trafficking signals that influence protein processing and cell surface expression. to characterize the role of the cytoplasmic domain in protein expression, fusion support and particle assembly in more detail, we constructed chimeric nipah virus (niv) glycoprotein (g) and canine distemper virus (cdv) haemagglutinin (h) proteins carrying the respective heterologous cytoplasmic domain, as well as a series of m ... | 2016 | 26813519 |
| prevalence and risk factors for viral exposure in rural dogs around protected areas of the atlantic forest. | despite the crucial role of domestic dogs as reservoirs for zoonosis and some of the most threatening diseases for wild carnivores such as distemper and parvovirosis, little is known about the epidemiological features and the risk factors involved in pathogen exposure of dogs that live in human/wildlife interfaces and actually contacts wildlife. through a cross-sectional serological approach and questionnaire survey, we assessed the prevalence along with individual and environment-associated ris ... | 2016 | 26822375 |
| correction: pathology in practice: canine distemper virus infection in a puppy. | 2016 | 26829273 | |
| circovirus in domestic and wild carnivores: an important opportunistic agent? | circoviruses are relatively novel pathogens with increased importance in canids. in this study, we first screened the presence of dog circovirus (dogcv) by molecular methods from a total number of 389 internal organ samples originating from 277 individuals of domestic dogs and wild animals including wolves, foxes and badgers. all the animals originated from central-southern italy, specifically from abruzzi and molise regions, areas hosting several natural parks. dogcv was detected in 9/34 wolves ... | 2016 | 26848830 |
| detection of arctic and european cluster of canine distemper virus in north and center of iran. | canine distemper virus (cdv) creates a very contagious viral multi-systemic canine distemper (cd) disease that affects most species of carnivora order. the virus is genetically heterogeneous, particularly in section of the hemagglutinin (h) gene. sequence analysis of the h gene can be useful to investigate distinction of various lineages related to geographical distribution and cdv molecular epidemiology. since vaccination program is conducted only in large cities of iran, cd still remains as on ... | 2015 | 26893808 |
| age-related presence of selected viral and bacterial pathogens in paraffin-embedded lung samples of dogs with pneumonia. | the aim of this retrospective study was to detect selected pathogens in pneumonic lung tissue of dogs of different age groups by immunohistochemistry (ihc), in situ hybridisation (ish) or polymerase chain reaction (pcr) in order to get information about their involvement in pneumonia formation. in archived formalin-fixed and paraffin wax-embedded lung samples from 68 cases with the clinical and histologic diagnosis of pneumonia the histological pattern of pneumonia was re-evaluated and the sampl ... | 2016 | 26919147 |
| canine distemper virus in wild felids of costa rica. | several highly infectious diseases can be transmitted through feces and cause elevated mortality among carnivore species. one such infectious agent, canine distemper virus (cdv; paramyxoviridae: morbillivirus), has been reported to affect wild carnivores, among them several felid species. we screened free-ranging and captive wild carnivores in costa rica for cdv. between 2006 and 2012, we collected 306 fecal samples from 70 jaguars (panther onca), 71 ocelots ( leopardus pardalis ), five jaguarun ... | 2016 | 26967127 |
| prevalence of common canine digestive problems compared with other health problems in teaching veterinary hospital, faculty of veterinary medicine, cairo university, egypt. | the present study was conducted to ascertain the prevalence of common digestive problems compared to other health problems among dogs that were admitted to the teaching veterinary hospital, faculty of veterinary medicine, cairo university, egypt during 1 year period from january to december 2013. also, study the effect of age, sex, breeds, and season on the distribution of digestive problems in dogs. | 2015 | 27047105 |
| coinfection with hepatozoon sp. and canine distemper virus in a yellow-throated marten ( martes flavigula koreana) in korea. | we describe coinfection with hepatozoon sp. and canine distemper virus (cdv) in a yellow-throated marten ( martes flavigula koreana). we found hepatozoon cysts in muscular tissue and viral inclusion bodies in the brain. hepatozoon sp., and cdv was confirmed in blood and brain, respectively, by pcr. | 2016 | 27054471 |
| phylogenetic analysis of canine distemper virus in south america clade 1 reveals unique molecular signatures of the local epidemic. | canine distemper virus (cdv) is a highly contagious pathogen for domestic dogs and several wild carnivore species. in brazil, natural infection of cdv in dogs is very high due to the large non-vaccinated dog population, a scenario that calls for new studies on the molecular epidemiology. this study investigates the phylodynamics and amino-acid signatures of cdv epidemic in south america by analyzing a large dataset compiled from publicly available sequences and also by collecting new samples fro ... | 2016 | 27060756 |
| post-mortem findings in southern right whales eubalaena australis at península valdés, argentina, 2003-2012. | between 2003 and 2012, 605 southern right whales (srw; eubalaena australis) were found dead along the shores of península valdés (pv), argentina. these deaths included alarmingly high annual losses between 2007 and 2012, a peak number of deaths (116) in 2012, and a significant number of deaths across years in calves-of-the-year (544 of 605 [89.9%]; average = 60.4 yr(-1)). post-mortem examination and pathogen testing were performed on 212 whales; 208 (98.1%) were calves-of-the-year and 48.0% of t ... | 2016 | 27068500 |
| influence of vaccine strains on the evolution of canine distemper virus. | 2016 | 27101783 | |
| measles virus fusion protein: structure, function and inhibition. | measles virus (mev), a highly contagious member of the paramyxoviridae family, causes measles in humans. the paramyxoviridae family of negative single-stranded enveloped viruses includes several important human and animal pathogens, with mev causing approximately 120,000 deaths annually. mev and canine distemper virus (cdv)-mediated diseases can be prevented by vaccination. however, sub-optimal vaccine delivery continues to foster mev outbreaks. post-exposure prophylaxis with antivirals has been ... | 2016 | 27110811 |
| serum antibody responses to vaccinal antigens in lean and obese geriatric dogs. | the immune responses in control dogs [1 to 4 years of age, body condition score (bcs): 4 to 5 out of 9] were compared to those of aging dogs (based on breed and body size) either categorized as lean (bcs: 4 to 5 out of 9) or obese (bcs: 8 to 9 out of 9). of interest were the serum titers to the following common agents found in vaccines, canine parainfluenza virus (cpiv), canine parvovirus (cpv), canine distemper virus (cdv), canine respiratory coronavirus (crcov), and bordetella bronchiseptica. ... | 2016 | 27152043 |
| diversity of susceptible hosts in canine distemper virus infection: a systematic review and data synthesis. | canine distemper virus (cdv) is the etiological agent of one of the most infectious diseases of domestic dogs, also known as a highly prevalent viral infectious disease of carnivores and posing a conservation threat to endangered species around the world. to get a better panorama of cdv infection in different orders, a retrospective and documental systematic review of the role of cdv in different non-dog hosts was conducted. the bibliographical data were collected from medline/pubmed and scopus ... | 2016 | 27170307 |
| detection and differentiation of wild-type and vaccine strains of canine distemper virus by a duplex reverse transcription polymerase chain reaction. | canine distemper virus (cdv) is the cause of canine distemper (cd) which is a severe and highly contagious disease in dogs. in the present study, a duplex reverse transcription polymerase chain reaction (rt-pcr) method was developed for the detection and differentiation of wild-type and vaccine strains of cdv. four primers were designed to detect and discriminate the two viruses by generating 638- and 781-bp cdna products, respectively. furthermore, the duplex rt-pcr method was used to detect 67 ... | 2015 | 27175171 |
| prevalence of antibodies for selected canine pathogens among wolves (canis lupus) from the alaska peninsula, usa. | we collected blood samples from wolves ( canis lupus ) on the alaska peninsula, southwest alaska, us, 2006-11 and tested sera for antibodies to canine adenovirus (cav), canine coronavirus (ccv), canine distemper virus (cdv), canine herpesvirus (chv), canine parainfluenza (cpi), canine parvovirus (cpv), neospora caninum , and toxoplasma gondii . detected antibody prevalence was 90% for cav, 28% for ccv, 12% for cdv, 93% for chv, 0% for cpi, 20% for cpv, 0% for n. caninum, and 86% for t. gondii . ... | 2016 | 27195683 |
| immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. | cdv-dl (canine distemper virus-induced demyelinating leukoencephalitis) represents a spontaneously occurring animal model for demyelinating disorders. axonopathy represents a key pathomechanism in this disease; however, its underlying pathogenesis has not been addressed in detail so far. this study aimed at the characterization of axonal cytoskeletal, transport, and potential regenerative changes with a parallel focus upon schwann cell remyelination. | 2016 | 27247850 |
| fatal canine distemper virus infection of giant pandas in china. | we report an outbreak of canine distemper virus (cdv) infection among endangered giant pandas (ailuropoda melanoleuca). five of six cdv infected giant pandas died. the surviving giant panda was previously vaccinated against cdv. genomic sequencing of cdv isolated from one of the infected pandas (giant panda/sx/2014) suggests it belongs to the asia-1 cluster. the hemagglutinin protein of the isolated virus and virus sequenced from lung samples originating from deceased giant pandas all possessed ... | 2016 | 27310722 |
| controversial results of therapy with mesenchymal stem cells in the acute phase of canine distemper disease. | distemper disease is an infectious disease reported in several species of domestic and wild carnivores. the high mortality rate of animals infected with canine distemper virus (cdv) treated with currently available therapies has driven the study of new efficacious treatments. mesenchymal stem cell (msc)-based therapy is a promising therapeutic option for many degenerative, hereditary, and inflammatory diseases. therefore, the aim of this study was to characterize stem cells derived from the cani ... | 2016 | 27323085 |
| epidemiology and clinical presentation of canine distemper disease in dogs and ferrets in australia, 2006-2014. | to determine the status and distribution of distemper in australian dogs and ferrets. | 2016 | 27349880 |
| occurrence of canine parvovirus in dogs from henan province of china in 2009-2014. | there is no information concerning the genotype of canine parvovirus (cpv) currently circulating in henan province, china. therefore, the aim of the present study was to provide insights into the epidemiology and molecular characterization of cpv circulating in henan province from 2009 to 2014. | 2016 | 27377264 |
| characterization of a novel canine distemper virus causing disease in wildlife. | canine distemper virus (cdv) is a common cause of a multisystemic disease in both domestic dogs and wildlife species, including raccoons and foxes. outbreaks of cdv in domestic dogs in eastern tennessee have occurred since 2012, and it was determined that these outbreaks resulted from a novel genotype of cdv. we hypothesized that this virus is also infecting area wildlife and may be a source of the virus for these outbreaks in dogs. from 2013 to 2014, autopsies were performed and tissues collect ... | 2016 | 27400957 |
| transcript profiling of toll-like receptor mrnas in selected tissues of mink (neovison vison). | toll-like receptors (tlrs) can recognize conserved molecular patterns and initiate a wide range of innate and adaptive immune responses against invading infectious agents. the aim of this study was to assess the transcript profile of mink tlrs (mtlrs) in mink peripheral blood mononuclear cells (pbmcs) and a range of tissues, and to explore the potential role of mtlrs in the antiviral immune response process. the results indicated that the mtlr partial nucleotide sequences had a high degree of nu ... | 2016 | 27435536 |
| canine distemper virus antibody titers in domestic cats after delivery of a live attenuated virus vaccine. | three methods for delivering a live attenuated canine distemper virus (cdv) vaccine to domestic cats ( felis catus ) were investigated, as models for developing vaccination protocols for tigers (panthera tigris). twenty domestic cats were randomly divided into four treatment groups: saline injection (negative controls); and oral, intranasal, and subcutaneous vaccinates. cats were injected with saline or a cdv vaccine (nobivac dp, merck) at wk 0 and 4. blood and nasal swabs were collected at wk 0 ... | 2016 | 27468028 |
| evaluation of two canine distemper virus vaccines in captive tigers (panthera tigris). | canine distemper virus (cdv) has caused clinical disease and death in nondomestic felids in both captive settings and in the wild. outbreaks resulting in high mortality rates in tigers (panthera tigris) have prompted some zoos to vaccinate tigers for cdv. in this study, six tigers received a recombinant canarypox-vectored cdv vaccine (1 ml s.c.) and were revaccinated with 3 ml s.c. (mean) 39 days later. blood collection for cdv antibody detection via serum neutralization was performed on (mean) ... | 2016 | 27468029 |
| exposure of free-ranging wild carnivores and domestic dogs to canine distemper virus and parvovirus in the cerrado of central brazil. | human population growth around protected areas increases the contact between wild and domestic animals, promoting disease transmission between them. this study investigates the exposure of free-ranging wild carnivores and domestic dogs to canine distemper virus (cdv) and parvovirus in emas national park (enp) in the cerrado savanna of central brazil. serum samples were collected from 169 wild carnivores, including the maned wolf (chrysocyon brachyurus), crab-eating fox (cerdocyon thous), hoary f ... | 2016 | 27469023 |
| evolutionary characteristics of morbilliviruses during serial passages in vitro: gradual attenuation of virus virulence. | the genus morbillivirus is classified into the family paramyxoviridae, and is composed of 6 members, namely measles virus (mv), rinderpest virus (rpv), peste-des-petits-ruminants virus (pprv), canine distemper virus (cdv), phocine distemper virus (pdv) and cetacean morbillivirus (cemv). the mv, rpv, pprv and cdv have been successfully attenuated through their serial passages in vitro for the production of live vaccines. it has been demonstrated that the morbilliviral virulence in animals was pro ... | 2016 | 27477502 |
| identification and characterization of the toll-like receptor 8 gene in the chinese raccoon dog (nyctereutes procyonoides). | tlr8 is an important sensor of single-stranded rna (ssrna) from the viral genome and plays an essential role in innate antiviral responses via the recognition of conserved viral molecular patterns. in this report, tlr8 in the chinese raccoon dog was characterized and analyzed for the first time. the full-length sequence of raccoon dog tlr8 (rdtlr8) cdna was cloned by rapid amplification of cdna ends (race) and is 3191bp with a 3117-bp open reading frame (orf) encoding 1038 amino acids. the putat ... | 2016 | 27481482 |
| canine distemper virus isolated from a monkey efficiently replicates on vero cells expressing non-human primate slam receptors but not human slam receptor. | in 2008, an outbreak of canine distemper virus (cdv) infection in monkeys was reported in china. we isolated cdv strain (subsequently named monkey-bj01-dv) from lung tissue obtained from a rhesus monkey that died in this outbreak. we evaluated the ability of this virus on vero cells expressing slam receptors from dog, monkey and human origin, and analyzed the h gene of monkey-bj01-dv with other strains. | 2016 | 27484638 |
| infectious progression of canine distemper virus from circulating cerebrospinal fluid into the central nervous system. | in the current study, we generated recombinant chimeric canine distemper viruses (cdvs) by replacing the hemagglutinin (h) and/or phosphoprotein (p) gene in an avirulent strain expressing enhanced green fluorescent protein (egfp) with those of a mouse-adapted neurovirulent strain. an in vitro experimental infection indicated that the chimeric cdvs possessing the h gene derived from the mouse-adapted cdv acquired infectivity for neural cells. these cells lack the cdv receptors that have been iden ... | 2016 | 27489268 |
| diversified anchoring features the peptide presentation of dla-88*50801: first structural insight into domestic dog mhc class i. | canines represent a crucial animal model for studying human diseases and organ transplantation, as well as the evolution of domestic animals. mhcs, with a central role in cellular immunity, are commonly used in the study of dog population genetics and genome evolution. however, the molecular basis for the peptide presentation of dog mhc remains largely unknown. in this study, peptide presentation by canine mhc class i dla-88*50801 was structurally determined, revealing diversified anchoring mode ... | 2016 | 27511732 |
| human ifit1 inhibits mrna translation of rubulaviruses but not other members of the paramyxoviridae family. | we have previously shown that ifit1 is primarily responsible for the antiviral action of interferon (ifn) alpha/beta against parainfluenza virus type 5 (piv5), selectively inhibiting the translation of piv5 mrnas. here we report that while piv2, piv5, and mumps virus (muv) are sensitive to ifit1, nonrubulavirus members of the paramyxoviridae such as piv3, sendai virus (sev), and canine distemper virus (cdv) are resistant. the ifit1 sensitivity of piv5 was not rescued by coinfection with an ifit1 ... | 2016 | 27512068 |
| detection of respiratory viruses in shelter dogs maintained under varying environmental conditions. | three dog shelters in rio grande do sul were investigated for associations between the occurrence of respiratory viruses and shelter environmental conditions. nasal secretions randomly collected during the cold season were tested via pcr, and this data collection was followed by nucleotide sequencing of the amplicons. in shelter #1 (poor sanitary and nutritional conditions, high animal density and constant contact between dogs), 78% (58/74) of the nasal samples were positive, 35% (26/74) of whic ... | 2017 | 27522932 |
| molecular surveillance of traditional and emerging pathogens associated with canine infectious respiratory disease. | a molecular survey for traditional and emerging pathogens associated with canine infectious respiratory disease (cird) was conducted in italy between 2011 and 2013 on a total of 138 dogs, including 78 early acute clinically ill cird animals, 22 non-clinical but exposed to clinically ill cird dogs and 38 cird convalescent dogs. the results showed that canine parainfluenza virus (cpiv) was the most commonly detected cird pathogen, followed by canine respiratory coronavirus (crcov), bordetella bron ... | 2016 | 27527760 |
| severe canine distemper outbreak in unvaccinated dogs in mozambique. | although significant animal suffering caused by preventable diseases is frequently seen in developing countries, reports of this are scarce. this report describes avoidable animal suffering owing to a suspected canine distemper (cd) outbreak in unvaccinated dogs owned by low-income families in mozambique that killed approximately 200 animals. affected dogs exhibited clinical signs, and gross and microscopic lesions compatible with cd. immunohistochemical staining confirmed the presence of canine ... | 2016 | 27543040 |
| immunoglobulins in dogs: correspondence and maturation in 15 litters of german shepherd dogs and their dams. | some dog breeds, including the german shepherd dog (gsd), are predisposed to immune-related disorders. the authors prospectively described development of serum and faecal iga and serum ige in gsd from puppies until adulthood and the relationship between mothers and their offspring. further, the authors tested whether dogs with lower serum iga also have low faecal iga and/or serum ige. to reveal whether any of the parameters could be proven to influence the immune response, the authors also measu ... | 2016 | 27547424 |
| screening red foxes (vulpes vulpes) for possible viral causes of encephalitis. | next to various known infectious and non-infectious causes, the aetiology of non-suppurative encephalitis in red foxes (vulpes vulpes) often remains unclear. known causes in foxes imply rabies, canine distemper, toxoplasmosis, aujeszky's disease, as well as parvovirus, adenovirus, circovirus and flavivirus infections. in this study, particular attention was paid on bornaviruses, since red foxes are predators of bicoloured white-toothed shrews, a reservoir of borna disease virus 1 (bodv-1). in ad ... | 2016 | 27590473 |
| development and application of multiplex pcr assays for detection of virus-induced respiratory disease complex in dogs. | canine infectious respiratory disease complex (cirdc) viruses have been detected in dogs with respiratory illness. canine influenza virus (civ), canine parainfluenza virus (cpiv), canine distemper virus (cdv), canine respiratory coronavirus (crcov), canine adenovirus type 2 (cadv-2) and canine herpesvirus 1 (cahv-1), are all associated with the cirdc. to allow diagnosis, two conventional multiplex polymerase chain reactions (pcr) were developed to simultaneously identify four rna and two dna vir ... | 2016 | 27628592 |
| myd88 and functionally related genes are associated with multiple infections in a model population of kenyan village dogs. | the purpose of this study was to seek associations between immunity-related molecular markers and endemic infections in a model population of african village dogs from northern kenya with no veterinary care and no selective breeding. a population of village dogs from northern kenya composed of three sub-populations from three different areas (84, 50 and 55 dogs) was studied. canine distemper virus (cdv), hepatozoon canis, microfilariae (acantocheilonema dracunculoides, acantocheilonema reconditu ... | 2016 | 27655108 |
| surveillance for viral and parasitic pathogens in a vulnerable african lion (panthera leo) population in the northern tuli game reserve, botswana. | african lion ( panthera leo ) numbers are decreasing rapidly and populations are becoming smaller and more fragmented. infectious diseases are one of numerous issues threatening free-ranging lion populations, and low-density populations are particularly at risk. we collected data on the prevalence and diversity of viral and parasitic pathogens in a small lion population in eastern botswana. during 2012 and 2014, blood samples were collected from 59% (n=13) of the adult-subadult lions in the nort ... | 2017 | 27669009 |
| infectious disease and toxicological monitoring of stranded pacific harbor seals (phoca vitulina richardsi) in cook inlet as surrogates for monitoring endangered belugas (delphinapterus leucas). | pacific harbor seals ( phoca vitulina richardsi) and belugas ( delphinapterus leucas ) eat many of the same prey species, occupy the same geographic area, and demonstrate site fidelity in cook inlet, alaska. although most direct research involving the critically endangered belugas is currently prohibited, studying harbor seals may provide important information about this beluga population. in recent years, harbor seal populations in alaska have declined for unknown reasons. as part of its strand ... | 2016 | 27691941 |
| application of xenogeneic anti-canine distemper virus antibodies in treatment of canine distemper puppies. | the clinical feasibility of passive immunotherapy has not been demonstrated in dogs naturally infected with canine distemper. in this study, porcine anti-canine distemper virus igg and f(ab')2 antibody fragments were used to treat infected puppies. | 2016 | 27726133 |
| morbillivirus experimental animal models: measles virus pathogenesis insights from canine distemper virus. | morbilliviruses share considerable structural and functional similarities. even though disease severity varies among the respective host species, the underlying pathogenesis and the clinical signs are comparable. thus, insights gained with one morbillivirus often apply to the other members of the genus. since the canine distemper virus (cdv) causes severe and often lethal disease in dogs and ferrets, it is an attractive model to characterize morbillivirus pathogenesis mechanisms and to evaluate ... | 2016 | 27727184 |
| enhanced immunosurveillance for animal morbilliviruses using vesicular stomatitis virus (vsv) pseudotypes. | the measurement of virus-specific neutralising antibodies represents the "gold-standard" for diagnostic serology. for animal morbilliviruses, such as peste des petits ruminants (pprv) or rinderpest virus (rpv), live virus-based neutralisation tests require high-level biocontainment to prevent the accidental escape of the infectious agents. in this study, we describe the adaptation of a replication-defective vesicular stomatitis virus (vsvĪ“g) based pseudotyping system for the measurement of neutr ... | 2016 | 27742221 |
| isolation and phylogenetic analysis of canine distemper virus among domestic dogs in vietnam. | canine distemper virus (cdv) is one of the most serious pathogens found in many species of carnivores, including domestic dogs. in this study, hemagglutinin (h) genes were detected in five domestic vietnamese dogs with diarrhea, and two cdvs were successfully isolated from dogs positive for h genes. the complete genome of one isolate, cdv/dog/hcm/33/140816, was determined. phylogenetic analysis showed that all vietnamese cdvs belonged to the asia-1 genotype. in addition, the h proteins of vietna ... | 2017 | 27746406 |
| the occurrence of pathogens in an endangered population of american badgers (taxidea taxus jacksoni) in ontario, canada. | american badgers ( taxidea taxus jacksoni) at the periphery of the species' range in ontario, canada, are listed as endangered because of an estimated population size of <200 mature individuals. the main threats faced by this population include habitat loss and road mortality. however, on 18 november 2013, a radio-implanted badger was found nonresponsive in an agricultural field with signs consistent with canine distemper virus infection, which was subsequently confirmed. this prompted our inves ... | 2017 | 27749192 |
| serosurvey for selected viral pathogens among sympatric species of the african large predator guild in northern botswana. | the recent increase in the creation of transboundary protected areas and wildlife corridors between them lends importance to information on pathogen prevalence and transmission among wildlife species that will become connected. one such initiative is the kavango zambezi transfrontier conservation area of which botswana's okavango delta constitutes a major contribution for wildlife and ecosystems. between 2008 and 2011, we collected serum samples from 14 lions ( panthera leo ), four leopards ( pa ... | 2017 | 27763827 |
| a new immunoassay of serum antibodies against peste des petits ruminants virus using quantum dots and a lateral-flow test strip. | a fast and ultrasensitive test-strip system combining quantum dots (qds) with a lateral-flow immunoassay strip (lfias) was established for detection of peste des petits ruminants virus (pprv) antibody. the highly luminescent water-soluble carboxyl-functionalized qds were used as the signal output and were conjugated to streptococcal protein g (spg), which was capable of binding to immunoglobulin g (igg) from many species through an amide bond to capture the target pprv iggs. the pprv n protein, ... | 2017 | 27783124 |
| multiplexed metagenomic deep sequencing to analyze the composition of high-priority pathogen reagents. | laboratories studying high-priority pathogens need comprehensive methods to confirm microbial species and strains while also detecting contamination. metagenomic deep sequencing (mds) inventories nucleic acids present in laboratory stocks, providing an unbiased assessment of pathogen identity, the extent of genomic variation, and the presence of contaminants. double-stranded cdna mds libraries were constructed from rna extracted from in vitro-passaged stocks of six viruses (la crosse virus, ebol ... | 2017 | 27822544 |
| reduced angiogenic gene expression in morbillivirus-triggered oncolysis in a translational model for histiocytic sarcoma. | histiocytic sarcoma represents a rare malignant tumour with a short survival time, indicating the need of novel treatment strategies including oncolytic virotherapy. the underlying molecular mechanisms of viral oncolysis are largely unknown. as cancer in companion animals shares striking similarities with human counterparts, we chose a permanent canine histiocytic sarcoma cell line (dh82 cells) to identify global transcriptome changes following infection with canine distemper virus (cdv), a para ... | 2017 | 27860224 |
| lethal distemper in badgers (meles meles) following epidemic in dogs and wolves. | canine distemper virus (cdv) represents an important conservation threat to many wild carnivores. a large distemper epidemic sustained by an arctic-lineage strain occurred in italy in 2013, mainly in the abruzzi region, causing overt disease in domestic and shepherd dogs, apennine wolves (canis lupus) and other wild carnivores. two badgers were collected by the end of september 2015 in a rural area of the abruzzi region and were demonstrated to be cdv-positive by real time rt-pcr and ihc in seve ... | 2016 | 27876612 |
| outbreak of severe pseudorabies virus infection in pig-offal-fed farmed mink in liaoning province, china. | an outbreak of severe pseudorabies virus (prv) infection in farmed mink occurred in northern china in late 2014, causing significant economic losses in the local fur industry. here, we report the first case of a prv outbreak in mink in northeastern china, caused by feeding farmed mink with raw pork or organs contaminated by prv. mink infected with virulent prv exhibited diarrhea, neurologic signs, and higher mortality, which can be misdiagnosed as highly pathogenic mink enteritis virus (mev), ca ... | 2017 | 27885561 |
| advances in canine distemper virus pathogenesis research: a wildlife perspective. | canine distemper virus (cdv) has emerged as a significant disease of wildlife, which is highly contagious and readily transmitted between susceptible hosts. initially described as an infectious disease of domestic dogs, it is now recognized as a global multi-host pathogen, infecting and causing mass mortalities in a wide range of carnivore species. the last decade has seen the effect of numerous cdv outbreaks in various wildlife populations. prevention of cdv requires a clear understanding of th ... | 2017 | 27902345 |
| persistent morbillivirus infection leads to altered cortactin distribution in histiocytic sarcoma cells with decreased cellular migration capacity. | histiocytic sarcomas represent rare but fatal neoplasms in humans. based on the absence of a commercially available human histiocytic sarcoma cell line the frequently affected dog displays a suitable translational model. canine distemper virus, closely related to measles virus, is a highly promising candidate for oncolytic virotherapy. therapeutic failures in patients are mostly associated with tumour invasion and metastasis often induced by misdirected cytoskeletal protein activities. thus, the ... | 2016 | 27911942 |
| canine distemper virus in the serengeti ecosystem: molecular adaptation to different carnivore species. | was the 1993/1994 fatal canine distemper virus (cdv) epidemic in lions and spotted hyaenas in the serengeti ecosystem caused by the recent spillover of a virulent domestic dog strain or one well adapted to these noncanids? we examine this question using sequence data from 13 'serengeti' strains including five complete genomes obtained between 1993 and 2011. phylogenetic and haplotype network analyses reveal that strains from noncanids during the epidemic were more closely related to each other t ... | 2016 | 27928865 |
| multiple-host pathogens in domestic hunting dogs in nicaragua's bosawás biosphere reserve. | nicaragua's bosawás biosphere reserve is a vast forested area inhabited largely by indigenous mayangna and miskitu people. most bosawás residents rely on subsistence hunting and swidden agriculture, and hunting dogs are important for finding and securing wild game. we investigated the health of hunting dogs in three communities differing in location, size, and economy. dogs in all communities were nutritionally compromised and experienced a heavy burden of disease. seroprevalence of canine diste ... | 2017 | 28012903 |
| commentary: slam- and nectin-4-independent noncytolytic spread of canine distemper virus in astrocytes. | 2016 | 28018332 | |
| impacts of canine distemper virus infection on the giant panda population from the perspective of gut microbiota. | the recent increase in infectious disease outbreaks has been directly linked to the global loss of biodiversity and the decline of some endangered species populations. between december 2014 and march 2015, five captive giant pandas died due to canine distemper virus (cdv) infection in china. cdv has taken a heavy toll on tigers and lions in recent years. here, we describe the first gut microbiome diversity study of cdv-infected pandas. by investigating the influence of cdv infection on gut bacte ... | 2017 | 28051146 |
| health survey of free-ranging raccoons (procyon lotor) in central park, new york, new york, usa: implications for human and domestic animal health. | we conducted health assessments on 113 free-ranging raccoons ( procyon lotor ) in central park, new york city, us, in february 2010, september 2010, and november 2011 in conjunction with a trap-vaccinate-release program to control a raccoon rabies epizootic. five individuals were sampled at two time points for 118 raccoon examinations in total. we tested 13 of 13 and 8 of 13 euthanized raccoons for rabies and canine distemper virus (cdv), respectively, by antigen testing on brain tissue; all wer ... | 2017 | 28135131 |
| inactivated recombinant rabies viruses displaying canine distemper virus glycoproteins induce protective immunity against both pathogens. | the development of multivalent vaccines is an attractive methodology for the simultaneous prevention of several infectious diseases in vulnerable populations. both canine distemper virus (cdv) and rabies virus (rabv) cause lethal disease in wild and domestic carnivores. while rabv vaccines are inactivated, the live-attenuated cdv vaccines retain residual virulence for highly susceptible wildlife species. in this study, we developed recombinant bivalent vaccine candidates based on recombinant vac ... | 2017 | 28148801 |
| the detection and differentiation of canine respiratory pathogens using oligonucleotide microarrays. | canine respiratory diseases are commonly seen in dogs along with co-infections with multiple respiratory pathogens, including viruses and bacteria. virus infections in even vaccinated dogs were also reported. the clinical signs caused by different respiratory etiological agents are similar, which makes differential diagnosis imperative. an oligonucleotide microarray system was developed in this study. the wild type and vaccine strains of canine distemper virus (cdv), influenza virus, canine herp ... | 2017 | 28189583 |
| pup mortality and evidence for pathogen exposure in galapagos sea lions (zalophus wollebaeki) on san cristobal island, galapagos, ecuador. | the galapagos sea lion ( zalophus wollebaeki ), an endangered species, experiences high pup mortality (up to 100%) in years when el niño events reduce food supply in the galapagos islands. mortality of pups in non-el niño years is estimated to be 5% in undisturbed colonies. from 2009 to 2012 we observed high pup mortality (up to 66%) in colonies close to the galapagos capital, puerto baquerizo moreno, where contact with humans, domestic animals, and rats is frequent. gross postmortem findings fr ... | 2017 | 28318380 |
| expression of canine distemper virus receptor nectin-4 in the central nervous system of dogs. | canine distemper virus (cdv) exhibits lymphotropic, epitheliotropic, and neurotropic nature, and causes a severe systemic infection in susceptible animals. initially, signaling lymphocyte activation molecule (slam) expressed on immune cells has been identified as a crucial cellular receptor for cdv. currently, nectin-4 expressed in epithelia has been shown to be another receptor for cdv. our previous study demonstrated that neurons express nectin-4 and are infected with cdv. in this study, we in ... | 2017 | 28336928 |
| polymerase spiral reaction (psr): a novel, visual isothermal amplification method for detection of canine parvovirus 2 genomic dna. | canine parvovirus-2 (cpv-2), which is ubiquitously distributed worldwide, causes severe and often fatal gastroenteritis in dogs. accurate, differential and rapid diagnosis of canine parvoviral enteritis remains a challenge for clinicians. a recently developed isothermal amplification technique, polymerase spiral reaction (psr), was optimized for the first time for a viral pathogen with reference recombinant plasmid standards from different cpv-2 antigenic variants (cpv-2, cpv-2a, cpv-2b and cpv- ... | 2017 | 28349355 |
| antibody response to paramyxoviruses in paget's disease of bone. | paget's disease of bone (pdb) is a common skeletal disorder characterised by focal abnormalities of increased and disorganised bone turnover. genetic factors play a central role in the pathogenesis of pdb but environmental factors also contribute. measles virus (mv), respiratory syncytial virus (rsv) and canine distemper virus (cdv) have all been implicated as potential disease triggers but the data are conflicting. since chronic paramyxovirus infection with measles is known to be accompanied by ... | 2017 | 28361207 |
| homologous recombination is a force in the evolution of canine distemper virus. | canine distemper virus (cdv) is the causative agent of canine distemper (cd) that is a highly contagious, lethal, multisystemic viral disease of receptive carnivores. the prevalence of cdv is a major concern in susceptible animals. presently, it is unclear whether intragenic recombination can contribute to gene mutations and segment reassortment in the virus. in this study, 25 full-length cdv genome sequences were subjected to phylogenetic and recombinational analyses. the results of phylogeneti ... | 2017 | 28394936 |
| pathological findings in the red fox (vulpes vulpes), stone marten (martes foina) and raccoon dog (nyctereutes procyonoides), with special emphasis on infectious and zoonotic agents in northern germany. | anthropogenic landscape changes contributed to the reduction of availability of habitats to wild animals. hence, the presence of wild terrestrial carnivores in urban and peri-urban sites has increased considerably over the years implying an increased risk of interspecies spillover of infectious diseases and the transmission of zoonoses. the present study provides a detailed characterisation of the health status of the red fox (vulpes vulpes), stone marten (martes foina) and raccoon dog (nyctereu ... | 2017 | 28399176 |
| development and characterization of canine distemper virus monoclonal antibodies. | five canine distemper virus monoclonal antibodies were developed by immunizing balb/c mice with a traditional vaccine strain snyder hill. among these monoclonal antibodies, four antibodies recognized both field and vaccine strains of canine distemper virus without neutralizing ability. one monoclonal antibody, 1a4, against hemagglutinin protein of canine distemper virus was found to react only with vaccine strain virus but not field isolates, and showed neutralizing activity to vaccine strain vi ... | 2017 | 28472594 |
| detection of morbillivirus infection by rt-pcr rflp analysis in cetaceans and carnivores. | morbillivirus genus comprises several members related to specific hosts, such as canine distemper virus (cdv) and cetacean morbillivirus (cemv) in which the dolphin morbillivirus (dmv) is included. both cdv and dmv are able to cause serious outbreak associated with high morbidity and mortality representing an important conservation threat for terrestrial and aquatic mammalian species. this paper describes a new rt-pcr rflp technique based on a rt-pcr with degenerate primers targeting a 287 bp fr ... | 2017 | 28528278 |
| a molecular survey for selected viral enteropathogens revealed a limited role of canine circovirus in the development of canine acute gastroenteritis. | canine circovirus (caninecv) is a canine virus, whose pathogenetic role is still uncertain. based on recent data suggesting its role as entheropathogen, a case-control study was conducted between 2013 and 2016 to investigate the association of caninecv with gastroenteritis in dogs, alone or in combination with other viral pathogens, including canine parvovirus (cpv), canine coronavirus (ccov) and canine distemper virus (cdv). a total of 219 dogs suffering from acute gastroenteritis disorders and ... | 2017 | 28532806 |
| prevalence of serum antibody titers against canine distemper virus and canine parvovirus in dogs hospitalized in an intensive care unit. | objective to determine the prevalence of dogs hospitalized in an intensive care unit (icu) with serum antibody titers against canine distemper virus (cdv) and canine parvovirus (cpv). design prospective observational study. animals 80 dogs. procedures dogs hospitalized in an icu for > 12 hours between february 1 and june 1, 2015, that had at least 0.25 ml of serum left over from diagnostic testing were eligible for study inclusion. dogs with serum antibody titers > 1:32 (as determined by serum n ... | 2017 | 28569640 |
| dimerization efficiency of canine distemper virus matrix protein regulates membrane budding activity. | paramyxoviruses rely on the matrix (m) protein to orchestrate viral assembly and budding at the plasma membrane. although mechanistic details remain largely unknown, structural data suggested that m dimers and/or higher oligomers may facilitate membrane budding. to gain functional insights, we here employed a structure-guided mutagenesis approach to investigate the role of canine distemper virus (cdv) m protein self-assembly in membrane budding activity. three six-alanine-scan (6a) block mutants ... | 2017 | 28592541 |
| cross-species transmission of canine distemper virus-an update. | canine distemper virus (cdv) is a pantropic morbillivirus with a worldwide distribution, which causes fatal disease in dogs. affected animals develop dyspnea, diarrhea, neurological signs and profound immunosuppression. systemic cdv infection, resembling distemper in domestic dogs, can be found also in wild canids (e.g. wolves, foxes), procyonids (e.g. raccoons, kinkajous), ailurids (e.g. red pandas), ursids (e.g. black bears, giant pandas), mustelids (e.g. ferrets, minks), viverrids (e.g. civet ... | 2015 | 28616465 |
| serology and protein electrophoresis for evidence of exposure to 12 mink pathogens in free-ranging american mink (neovison vison) in argentina. | basic pathologic characteristics for farmed minks were previously reported worldwide. however, its status in the wild has not been studied in detail. | 2017 | 28635524 |