Publications

q fever in patients with hepatitis and pneumonia: results of laboratory-based surveillance in the united states.		1988	3042883
the severity model of chronic headache.		2011	3042933
[rickettsiaceae infections and fluoroquinolones].	twenty nine patients with rickettsiosis (tick born fever, n: 22, q fever, n: 7) has been treated with fluoroquinolones. these compounds was used alone n: 25 (pefloxacin, n: 15; ofloxacin, n: 10) or associated n: 4 (pefloxacin + rifampin). the general efficacy was excellent. common tick born fever and pulmonary forms of q fever was fast cured. severe tick born fever (neurologic or polyvisceral forms, n: 5) and q fever with long term hyperthermia, n: 4 cas always cured without complications but th ...	1988	3043346
embryonic loss in mares. incidence, possible causes, and diagnostic considerations.	fertilization rates were similar for normal and subfertile mares, and much of the difference in fertility between normal and subfertile mares was due to embryonic loss. fertilization rate estimates for mares ranged from 71 to 96 per cent. the incidence of embryonic loss detected by ultrasonography between days 11 and 50 was approximately 9 per cent for normal mares, and the estimated incidence of embryonic loss before day 14 was also 9 per cent. therefore, the estimated incidence of embryonic lo ...	1988	3044540
prophylactic injection sclerotherapy for esophageal varices: a critical appraisal.		2010	3044915
[information value of the clinical, personality and psychosocial characteristics of schizophrenics for the prognosis of results of rehabilitative therapy].	the authors compared formalized case records contained in the data bank "rehabilitative automated information system" (rais) for two groups of schizophrenics who have received a course of restorative therapy. the first group consists of 173 patients with a and b remissions, the second one, of 155 patients with d and c remissions and without remissions. the authors have analyzed 487 morbid characteristics of patients and identified 209 of them, which allow the differentiation of the groups under ...	2011	3046208
q fever following bone marrow transplantation.	we describe a patient who developed an acute febrile illness 85 days after receiving an allogeneic bone marrow transplant for acute myeloid leukaemia. serological investigation indicated the cause to be q fever. the patient was receiving concurrent immunosuppressive therapy for graft-versus-host disease (gvhd). coxiella burnetii should be added to the list of organisms which may complicate bone marrow transplantation. this case also provides further evidence to support an association between imm ...	1988	3048481
systemic infections affecting the liver. some cause jaundice, some do not.	the patient who has clinical jaundice, abnormal results on liver function tests, or both presents a difficult diagnostic challenge. many infectious diseases affect the liver, and the extent of involvement determines the degree of clinically apparent jaundice. some diseases that affect the liver minimally cause no jaundice at all. an important clue to the cause of the disorder is the pattern of abnormal results on liver function tests. increased alkaline phosphatase predominates with q fever, sec ...	1988	3050927
[acute renal insufficiency and non-steroidal anti-inflammatory drugs].	non-steroid anti-inflammatory drugs cause an increasing number of renal disorders because of their increasing use. in addition to a toxic or immuno-allergic mechanism common to many medications, the side-effects are essentially related to the inhibition of prostaglandins biosynthesis which play a major role as soon as the renal blood flow is compromised. acute renal failure of hemodynamic origin, interstitial nephropathy with or without nephrotic syndrome are the most characteristic manifestatio ...	2011	3051319
chemical and immunochemical studies on lipopolysaccharides of coxiella burnetii phase i and phase ii.	lipopolysaccharides of coxiella burnetii phase i and ii were comparatively investigated by chemical and immunochemical methods. lps of phase i (lps i) and phase ii cells (lps ii) show no serological cross reaction, indicating that the serological determinants of lps ii are masked in lps i. chemical analysis of lps i and ii show that phase i and ii cells can be considered as s and r forms of coxiella burnetii. the structure of lps ii has recently been elucidated and shows a dimannosylated core of ...	1988	3051921
enzyme-linked immunosorbent assay for diagnosis of chronic q fever.	from 1982 through 1987 we diagnosed 13 chronic q fever cases. clinically these patients presented a culture-negative endocarditis, and all but two had high complement-fixing antibody titers to coxiella burnetii phase i (reciprocal titer above 200). with the enzyme-linked immunosorbent assay (elisa), titers of immunoglobulin g (igg) to phases i and ii of c. burnetii averaged 158,000 and 69,900, respectively, whereas they reached 300 and 3,200 in acute q fever cases. similarly, iga to both phases ...	1988	3053757
evaluation of different fixatives and treatments for immunohistochemical demonstration of coxiella burnetti in paraffin-embedded tissues.	various fixatives and treatments such as acetone, methanol, bouin fixative, modified bouin fixative, 10% formalin, modified methacarn, periodate-lysine-paraformaldehyde, acetone-methyl benzoate-xylene, and edta were evaluated for their effect on the immunoreactivity of coxiella burnetii in paraffin-embedded tissues by using the avidin-biotin-peroxidase complex and the peroxidase-antiperoxidase procedure. c. burnetii antigen was shown to be present in liver, spleen, and uterus tissues of experime ...	1988	3053760
experience with trimethoprim-sulfamethoxazole in treatment of infective endocarditis.	the published experience with trimethoprim-sulfamethoxazole (tmp-smz) for treatment of infective endocarditis was reviewed. among 62 cases, a high proportion had unusual causative organisms: 60% of cases were due to coxiella burnetii or pseudomonas species. only 17% of patients had previously normal cardiac valves. patients often had complicated courses in which tmp-smz was tried only after other treatment regimens had failed, yet a successful outcome was achieved in 61% of cases. thirty-five pa ...	1988	3055189
gadolinium-dtpa-enhanced mr imaging of spinal neoplasms: preliminary investigation and comparison with unenhanced spin-echo and stir sequences.	unenhanced t1- and t2-weighted spin-echo, short inversion time inversion recovery (stir), and gadolinium-dtpa (gd-dtpa)-enhanced spin-echo and stir imaging techniques were used in 20 patients as part of a multicenter study to assess the safety and efficacy of gd-dtpa in spinal imaging. five patients had normal mr scans. of those with lesions, both gd-dtpa-enhanced t1-weighted spin-echo and unenhanced stir scans improved detection and evaluation of spinal tumors over conventional spin-echo method ...	2011	3055895
ixodes dammini: evidence for salivary prostacyclin secretion.	pilocarpine-induced saliva of adult ixodes dammini ticks contained abundant amounts (523 +/- 140 ng/ml, mean +/- se, n = 14) of 6-keto-pgf1 alpha, the stable degradation product of prostacyclin. this prostaglandin was identified by radioimmunoassay and reversed-phase chromatography. this activity may help tick feeding by preventing host hemostatic reactions, by increasing host blood flow at the tick feeding site, and by preventing leukocyte degranulation.	1988	3057165
[pharmacokinetics of theophylline in children with acute asthmatic crisis].	in order to defined the theophylline dose which produce effective theophylline concentrations with less number of plasmatic controls, we analyzed the theophylline pharmacokinetics of 18 boys and girls between 3-12 year olds of tarragona, to which we administered 6 mg/kg/6 h of aminophylline by iv intermittent infusion (30 min), following by rapid-release po aminophylline at the same dose and intervals. in steady-state we did the pharmacokinetic studies at 1 h, 4 h and 6 h after the administratio ...	2011	3057979
cyclophosphamide-induced liver necrosis: a possible interaction with azathioprine.	cyclophosphamide is a valuable drug for the treatment of vasculitis and hepatic toxicity resulting from its use has been reported rarely. we describe four patients in whom cyclophosphamide was associated with liver injury when its administration had been preceded by azathioprine. microscopy of hepatic biopsy material in three of these cases showed liver cell necrosis. in two of the patients, cyclophosphamide had been given previously without earlier azathioprine and hepatic damage had not been n ...	2011	3060893
seroepidemiology of q fever in new brunswick and manitoba.	a seroepidemiological survey, using an indirect immunofluorescence test, was carried out on serum samples obtained from new brunswick and manitoba blood donors during 1986. the antigens were coxiella burnetii phase i and phase ii from strain nine mile. eighty of the 503 (15.9%) manitoba blood donors had a phase ii antibody titer of greater than or equal to 1:8, while 41 (4.2%) of the 966 new brunswick blood donors had such antibodies. we have recently diagnosed three cases of q fever in new brun ...	1988	3063363
the untreated, shrinking simple bone cavity: case report.		2008	3064707
performance and management of children with unilateral sensorineural hearing loss.	this paper reviews the status of children with unilateral sensorineural hearing loss. there is mounting evidence to show that some unilaterally hearing-impaired children experience difficulty in school. furthermore, these children may have trouble understanding speech in noise, exhibit poor localization skills, and display behavior problems in school and at home. suggested management strategies for this population are discussed.	2011	3067327
[collagen and its constitutional disorders].		2011	3067651
enzyme-linked immunosorbent fluorescence assay and high-pressure liquid chromatography for analysis of humoral immune responses to coxiella burnetti proteins.	a microtiter enzyme-linked immunosorbent fluorescence assay based on alkaline phosphatase conjugate and 4-methylumbelliferyl phosphate as fluorogenic substrate was developed and adapted to quantitatively analyze immunoglobulin g subclass 1 (igg1) and igg2 responses of vaccinated and infected cattle to proteins of coxiella burnetii. the enzyme-linked immunosorbent fluorescence assay surpassed the conventional enzyme-linked immunosorbent assay with a 50-fold-higher sensitivity and a broader range ...	1988	3068247
effects of 2-(3-methyl-cinnamyl-hydrazono)-propionate on fatty acid and glucose oxidation in the isolated rat diaphragm using 14c-labelled substrates. hydrazonopropionic acids, a new class of hypoglycaemic substances, viii.	the influence of 2-(3-methyl-cinnamyl-hydrazono)-propionate on the utilization of various substrates in isolated rat hemidiaphragms was investigated in comparison with other hypoglycaemic compounds. the effect of 2-(3-methyl-cinnamyl-hydrazono)-propionate was concentration-dependent. at a concentration of 0.5 mmol/l 2-(3-methyl-cinnamyl-hydrazono)-propionate, glucose utilization increased from 0.276 +/- 0.043 mumol.g-1.l-1 to 0.894 +/- 0.303 mumol.g-1.l-1 (p less than 0.05). pyruvate and lactate ...	1988	3069950
[the clinical importance of the pre-excitation syndrome].		2010	3070162
[clinical trial of immunoregulation using the tfx polfa preparation in non-hodgkin's lymphoma].		2011	3070639
a longitudinal ultrastructural study of pancreatic cellular damage in murine streptozotocin diabetes.	using islets obtained by collagenase digestion, we have carried out a longitudinal study of the ultrastructure of endocrine cells of the islets of langerhans from c57bl/6 mice, during the development of diabetes induced by the multiple low-dose streptozotocin (mld stz) technique, with and without co-treatment with complete freund's adjuvant (cfa). diabetes, as assessed by glycemia, occurred on different days in the various treatment groups following the initial stz injection. it was observed on ...	2011	3071064
production of recombinant human colony stimulating factors in yeast.	efficient yeast expression and purification systems for production of recombinant human gm-csf, il-3 and g-csf have been established. though yeast-derived production of recombinant csfs (through the use of secretion based system) allows for generation of native molecules which can then be readily separated from fermentation broth, in many instances, natural cdnas have had to be altered to allow for efficient expression, as well as production of a less heterogeneous product. in the case of csfs d ...	1988	3071326
localization of the kras2 oncogene in the domestic rabbit (oryctolagus cuniculus).	the kras2 gene was localized in the rabbit by chromosomal in situ hybridization, using a 3h-labeled human cdna probe. there were 201 silver grains on 144 metaphase spreads; 12.9% of the grains resided on chromosome 16, and 54% of these grains were located close to the centromere at 16p11----q11. statistical analysis indicated that labeling at this region represents a significant deviation from a random distribution and thus provided evidence for the assignment of kras2 to 16p11----q11. in additi ...	1988	3073912
nih consensus conference statement: dental implants.		2010	3075969
nih consensus conference statement: dental implants.		2010	3075969
estrogenic control of spermidine/spermine n1-acetyltransferase activity in rat uterus.		1988	3076330
[q fever as a disease of humans and animals].		1988	3076653
invited contribution: an objective approach to the development of short-term tests predictive of carcinogenicity.	the carcinogenicity prediction and battery selection procedure was developed to address two problems: (1) the identification of highly predictive, yet cost-effective, batteries of short-term tests and (2) the objective prediction of the potential carcinogenicity of chemicals based upon the results of short-term tests even when a mixture of positive and negative results is obtained. in the present report the usefulness of the carcinogenicity prediction and battery selection procedure is demonstra ...	2011	3077082
ultrasound scanning in the detection of hepatic fibrosis and steatosis.	hepatic steatosis and fibrosis produce abnormal echo patterns on ultrasound scanning, but the potential of ultrasound scanning for diagnosing these conditions in routine clinical practice is uncertain. a prospective comparative study of 85 patients with histologically assessed liver conditions was performed, and specificity was assessed in 76 patients with functional bowel disease who were presumed to have normal livers. histological examination showed steatosis ranging from mild to severe in 48 ...	2011	3080046
diclofenac sodium versus pethidine in acute renal colic.		2011	3081085
q fever among slaughterhouse workers--california.		1986	3083226
preliminary investigations of a correlation between electron energy loss and morphometric analyses on ultrathin cryosections from normal and neoplastic gastric tissues.	electron energy loss spectroscopy (eels) has been used to measure the ratios of c, n, o, p and ca in ultrathin cryosections from normal and neoplastic gastric tissues. first results show a correlation between the eels, and morphometric data in cells from these tissues. we have found that ultrathin, freeze-dried cryosections, with an average thickness of up to 75 nm, are stable enough for eels-analysis in a 200 kv electron microscope with an adapted gatan-eels-spectrometer.	2011	3085333
positive correlation between the level of protein-carboxyl methylase in spermatozoa and sperm motility.	levels of protein-carboxyl methylase (pcm) activity were measured in spermatozoa from infertile patients with less than 50% sperm motility and compared with those of normal fertile controls. when spermatozoa were washed by a standard centrifugation procedure, the level of pcm activity in a subgroup of patients with sperm motility ranging from 0% and 20% (24.0 +/- 5.2 pmol/mg protein, mean +/- standard error of the mean) was significantly different from that of controls (35.9 +/- 2.3 pmol/mg). ho ...	2011	3086132
the effect of alpha-difluoromethylornithine on natural killer cell and tumoricidal macrophage induction by interferon in vivo.	the objective of the present investigation was to evaluate the effect of dfmo (dl-alpha-difluoromethylornithine hcl h2o) administration on tumoricidal effector cell generation by ifn or ifn inducers in vivo. dfmo administration reduces both splenic leukocyte and peritoneal macrophage polyamine levels. in tumor bearing (b16 melanoma) mice, dfmo administration did not impair splenic natural killer (nk) cell augmentation, assessed against nk sensitive yac-1 target cells, by ifn alpha/beta or the if ...	2010	3086243
associations between symptoms of irritable colon and psychological and social conditions and lifestyle.	in a survey of risk factors for coronary heart disease 14 102 middle aged men and women answered a questionnaire on lifestyle, diet, and health, including symptoms of functional abdominal disorders. the overall prevalence of reports of one or both of the abdominal symptoms of "bloating and rumbling" or "cramping abdominal pain" was 28% in men and 35% in women. only a weak negative association between age and prevalence of reported pain was found in both sexes. women reported abdominal symptoms, ...	2010	3087551
adherent spleen cell production of e series prostaglandins in rats bearing variants of the r3327 dunning prostatic adenocarcinoma: effect of cyclophosphamide.	prostaglandins of the e series (pge) have been implicated in many facets of immunoregulation, as well as having a possible role in metastatic dissemination. variant sublines of the dunning r3327 rat prostatic adenocarcinoma, differing in growth rate, hormonal responsiveness and in propensity for metastasis, were carried in fisher x copenhagen f1 animals. adherent spleen cells were assayed in vitro for their ability to convert arachidonic acid to prostaglandins of the e series. these glass adhere ...	1986	3088126
selenium status of malnourished hospitalized patients.	we evaluated selenium (se) status of 44 hospitalized patients with protein-energy malnutrition. the patients were assigned to "normal" or "low" se groups-1 and 2, respectively-based on whether the plasma se level exceeded or was below the value of the mean-2sd of healthy georgians'. plasma and erythrocyte se levels correlated significantly (r = .52, p less than .01). erythrocyte glutathione peroxidase activity was highly correlated with plasma se (r = .68) in group 2; there was no significant co ...	2011	3090129
does your grouper 'over-maximize' reimbursement?		2011	3093366
calspectin (fodrin or nonerythroid spectrin)-actin interaction: a possible involvement of 4.1-related protein.	the calspectin/actin complex extracted from the bovine brain membrane crosslinks f-actin, resulting in the increasing viscosity of f-actin determined by low-shear viscometry. we demonstrated the presence of a protein factor in this complex, which regulated the calspectin-f-actin interaction in a ca2+- and calmodulin-dependent manner. erythrocyte protein 4.1, but not synapsin i, mimics the function of this brain factor using a reconstitution system including purified calspectin, calmodulin and f- ...	1986	3096326
the effects of alpha adrenergic blockade on arachidonic acid metabolism and shock sequelae in endotoxemia.	previous studies have suggested that increased alpha adrenergic activity stimulated prostaglandin synthesis and may be involved in the modulation of eicosanoid metabolism. these observations prompted investigation of the effect of the alpha adrenergic receptor antagonist phenoxybenzamine and the cyclo-oxygenase inhibitor indomethacin on endotoxin-induced shock severity, and on plasma immunoreactive itxb2 and i6-keto-pgf1 alpha, the stable metabolites of txa2 and pgi2, respectively. pretreatment ...	1986	3096591
inactivation of metalloenzymes by food constituents.	phenylethylaminoalanine (peaa), derived from biogenic phenylethylamine and dehydroalanine, inhibited the enzymatic activity of the metalloenzyme, carboxypeptidase a (cpa). the inhibition was maximal at ph 7.0 in the ph range 7-8.5. the extent of inhibition increased with time of treatment and peaa concentration. n-acetylpeaa did not inhibit the enzyme, suggesting that the free alpha-nh2 group is required for inhibition. peaa also inactivated the copper enzyme, polyphenol oxidase (tyrosinase). co ...	2010	3096851
inactivation of metalloenzymes by food constituents.	phenylethylaminoalanine (peaa), derived from biogenic phenylethylamine and dehydroalanine, inhibited the enzymatic activity of the metalloenzyme, carboxypeptidase a (cpa). the inhibition was maximal at ph 7.0 in the ph range 7-8.5. the extent of inhibition increased with time of treatment and peaa concentration. n-acetylpeaa did not inhibit the enzyme, suggesting that the free alpha-nh2 group is required for inhibition. peaa also inactivated the copper enzyme, polyphenol oxidase (tyrosinase). co ...	2010	3096851
[the rights of man--the action and compromise].		1986	3101182
platelet activation induced by fmlp-stimulated neutrophils.		2011	3101445
iodine-131 mibg scintigraphy of the extremities in metastatic pheochromocytoma and neuroblastoma.	iodine-131 mibg scintigraphy may be used to determine the presence or absence of metastases to the appendicular skeleton in malignant pheochromocytoma and neuroblastoma. normal bones show no uptake of [131i]mibg and the joints are seen as photon-deficient areas surrounded by background muscle activity. discrete concentrations of radioactivity in bone are often seen in patients with malignant pheochromocytoma and neuroblastoma. bone marrow involvement in neuroblastoma may be indicated by diffuse ...	2011	3102702
in vitro excystation of sarcocystis capracanis, sarcocystis cruzi and sarcocystis tenella (apicomplexa).	improved rates of in vitro excystation of sporozoites from sporocysts of sarcocystis capracanis, sarcocystis cruzi, and sarcocystis tenella were obtained by pretreating sporocysts with an aqueous sodium hypochlorite (naocl) solution followed by incubation in excysting fluid (ef). after pretreatment with naocl, sporocysts were washed 4 times in hanks' balanced salt solution and then incubated in various ef (ph 7.4) at 38.5 c in 5% co2-95% air. maximum rates of excystation (free sporozoites/(sporo ...	1986	3102713
cloning and functional expression of the coxiella burnetii citrate synthase gene in escherichia coli.	the citrate synthase gene from the obligate intracellular rickettsial parasite coxiella burnetii was cloned and expressed in escherichia coli. transduction into e. coli with a c. burnetii gene library constructed in the cosmid vector phk17 resulted in the functional complementation of the glta mutation of e. coli mob154. a glta+ clone carrying 16.4 kilobase pairs of c. burnetii dna and designated pjcc959 was isolated and characterized. southern hybridization analysis confirmed that the pjcc959 c ...	1987	3104207
comments on hcfa hospital death rate statistical outliers. health care financing administration.	in march 1986, the health care financing administration (hcfa) released ten lists of death-rate "outlier" hospitals, one for all 1984 medicare discharges and nine for specific drgs. recent medicare hospital discharge abstracts have substantially undercounted in-hospital deaths, with large variations by state. apart from the proportion of a hospital's cases in 80 drgs, the predictive models had no measures of case severity based on diagnosis or procedure. having drg 123 (all deaths from acute myo ...	1987	3106265
serologic evidence of acute murine typhus infection in a patient with culture-negative endocarditis.	a patient with culture-negative infective endocarditis is presented in whom detailed serological studies were indicative of acute infection with murine typhus. the patient had aortic and mitral regurgitation with congestive heart failure and typical peripheral manifestations of subacute endocarditis, but no documented fever. aortic and mitral valve replacement surgery and a 6-week course of doxycycline therapy produced a clinical cure in this patient, as well as a diagnostic fall in markedly ele ...	1987	3109241
serum triiodothyronine and thyroxine concentrations in weanling horses fed carbohydrate by direct gastric infusion.	plasma glucose and serum insulin, thyroxine, and triiodothyronine concentrations were monitored in 6 weanling thoroughbreds after direct gastric infusion of solutions containing sucrose or casein. neither plasma glucose nor serum hormone concentrations were affected by infusions of water or by infusions of 326 or 424 g of casein/250 kg of body weight. however, glucose and hormone concentrations increased significantly (p less than 0.001) after infusions of 649 or 844 g of sucrose/250 kg. initial ...	2011	3109287
purification and characterization of dihydrofolate reductase from soybean seedlings.	dihydrofolate reductase (dhfr; ec 1.5.1.3) was purified to homogeneity from soybean seedlings by affinity chromatography on methotrexate-aminohexyl sepharose, gel filtration on ultrogel aca-54, and blue sepharose chromatography. sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the enzyme gave a single protein band corresponding to a molecular weight of 22,000. the enzyme is not a 140,000 da heteropolymer as reported by others. amino acid sequence-specific antibodies to intact human d ...	1987	3109322
purification and characterization of dihydrofolate reductase from soybean seedlings.	dihydrofolate reductase (dhfr; ec 1.5.1.3) was purified to homogeneity from soybean seedlings by affinity chromatography on methotrexate-aminohexyl sepharose, gel filtration on ultrogel aca-54, and blue sepharose chromatography. sodium dodecyl sulfate-polyacrylamide gel electrophoresis of the enzyme gave a single protein band corresponding to a molecular weight of 22,000. the enzyme is not a 140,000 da heteropolymer as reported by others. amino acid sequence-specific antibodies to intact human d ...	1987	3109322
cloning of reticulocyte lipoxygenase mrna.		1987	3109402
alcohol and ischaemic heart disease in middle aged british men.		2011	3109619
biosynthesis of chlortetracycline. part iii--hydroxylation of l-phenylalanine to l-tyrosine by streptomyces aureofaciens and its relation to the biosynthesis of chlortetracycline.		1986	3110112
[occurrence of coxiellosis and chlamydiosis in sumava].	the occurrence of antibodies to c. burnetii and chl. psittaci was studied in the herds of cattle transported from southern moravia to the pastures of the sumava mountains. q-fever persists in latent state in the cattle grazing in the sumava mts. and causes no manifest infections in man. the finding of the rickettsia in the small mammals and their ectoparasites documents the probability of contact with the causal agent in the excretions of cattle in the pastures. veterinary and human medical serv ...	1987	3111066
[study of the reactivity and immunogenicity of a combined vaccine against abortion due to coxiellosis and chlamydiosis in sheep].	reactogenicity was studied in a combined vaccine against q-fever and chlamydia-induced abortion in ewes; the vaccine consisted of a mixture of purified corpuscles of chlamydia psittaci (100 micrograms) and coxiella burnetii (50 micrograms). the immunogenicity of the combined vaccine, evaluated by the number of positive serums after vaccination and by the average geometric titre of antibodies, was the same as that of the vaccine separate constituents as to the antibodies to c. burnetii, but somew ...	1987	3111068
[demonstration of antibodies against chlamydia psittaci and coxiella burnetii in dogs and cats: comparison of the enzyme immunoassay, immunoperoxidase technic, complement fixation test and agar gel precipitation test].		1987	3113133
diagnostic value of thyrotropin-releasing-hormone stimulation in patients with pituitary tumor.	plasma prolactin response to thyrotropin-releasing-hormone (trh) stimulation was diminished in 30 patients with prolactinomas and 9 patients with acromegaly who had normal serum prolactin levels. there was no overlap of prolactin responses when compared with 32 control patients. responses of ten patients with adrenocorticotropin (acth)-secreting pituitary tumors were similar to those of controls. plasma growth hormone concentrations after trh stimulation changed significantly in 28% of normal co ...	2001	3116772
correlation of morphologic brain lesions with physiologic alterations and blood-brain barrier impairment in 3-nitropropionic acid toxicity in rats.	3-nitropropionic acid (npa), a toxin which irreversibly inhibits the krebs cycle enzyme succinate dehydrogenase, causes severe neurologic disease and a specific pattern of morphologic brain damage when given subcutaneously to rats. to determine whether hypotension or hypoxemia were necessary for development of morphologic brain lesions in npa neurotoxicity, systemic blood pressure and arterial blood gases were measured in npa-intoxicated rats. the extent and distribution of albumin extravasation ...	1987	3116820
isolation of a protein antigen from coxiella burnetii.	antigens prepared from coxiella burnetti, strain frankfurt, phase ii, propagated in persistently infected buffalo green monkey (bgm) cell cultures were purified by guanidinium hydrochloride treatment and chloroform/methanol extraction. by elisa analysis, chloroform/methanol residues (cmr) proved to be free of host cell antigens. the cmr were sensitive to trypsin, pronase e and proteinase k, as determined by absorption-kinetics of cmr suspensions at 600 nm and release of protein. coomassie blue s ...	1987	3118597
novel transcripts from the ultrabithorax domain of the bithorax complex.	we present a detailed analysis of the transcriptional products of the bithoraxoid (bxd) region of the ultrabithorax domain in the bithorax complex of drosophila melanogaster. this region is transcribed twice during development: between 3 and 6 hr of embryogenesis, a set of early transcripts, 1.1 to 1.3 kb in size, is synthesized; from the midthird larval instar through the adult stages, a late 0.8-kb transcript is synthesized. we have sequenced five cloned cdnas representing early transcripts an ...	2010	3119423
ensuring the safety of deaf children in residential schools.	in 1983, 75,000 to 90,000 children and youth in the united states had hearing impairments severe enough to warrant some sort of special education, and 28% of that total (i.e., 21,000 to 25,000) were in residential schools. deaf youngsters in institutional settings are at risk for maltreatment by surrogate caretakers--foster parents or institutional child care workers. attempts to report the abuse may produce denials by institutional administrators who do not want to believe that children under t ...	2009	3120102
ensuring the safety of deaf children in residential schools.	in 1983, 75,000 to 90,000 children and youth in the united states had hearing impairments severe enough to warrant some sort of special education, and 28% of that total (i.e., 21,000 to 25,000) were in residential schools. deaf youngsters in institutional settings are at risk for maltreatment by surrogate caretakers--foster parents or institutional child care workers. attempts to report the abuse may produce denials by institutional administrators who do not want to believe that children under t ...	2009	3120102
feeding gastrostomy: nutritional management of the infant or young child.		2011	3121840
the capnograph, a reliable non-invasive monitor for the detection of pulmonary embolism of various origin.	the wash-out curve in the capnogram is known to be a sign of pulmonary air embolism. this characteristic pattern is also seen in the case of pulmonary embolism of other nature. capnographic recordings were studied retrospectively and 22 wash-out curves were found. the quantitative change in end-tidal carbon dioxide concentration was compared with the change in other, circulatory parameters known to change in the case of pulmonary air embolism. there proved to be a quantitative correlation betwee ...	2011	3122512
airway hyperresponsiveness: therapeutic implications.	in summary, this article has reviewed the importance of airway inflammation in the pathogenesis of asthma. inflammatory triggering factors (allergen, low molecular weight sensitizing chemicals, viral urti) are more important in the pathogenesis of asthma than the bronchospastic triggering factors. likewise, anti-inflammatory treatment strategies (environmental control, sodium cromoglycate, steroids) are more important in the long-term control of asthma than are the purely bronchodilator strategi ...	2011	3122604
lactate dehydrogenase and malate dehydrogenase of sertoli cells in rats.	lactate-dehydrogenase (ldh) and malate-dehydrogenase (mdh) activities and isozyme patterns of maturing sertoli cells were investigated in cultured cells obtained from 2-5-week-old rats. both enzymes, and more strikingly ldh, increased between 2 and 3 weeks of age. ldh isozyme complement included all five isozymes and, in the more mature rats, had a shift toward the isoforms rich in subunit. these data are consistent with an increasing production of lactate/pyruvate and with a finer regulation of ...	1987	3122678
cost effectiveness of biofeedback and behavioral medicine treatments: a review of the literature.	this paper reviews multicomponent behavioral medicine studies that contain cost-effectiveness and or cost-benefit data relevant to the field of biofeedback and relaxation training, primarily when assisted by biofeedback, with or without stress management, in the treatment of psychosomatic illness and pain. a model for evaluating biofeedback treatment is presented. cost-effectiveness data concerning reduction in physician visits and/or medication use, decrease in medical care costs to patients, r ...	2011	3122851
waxman cites the government's policy failures. interview by jeffrey finn.		2011	3123353
a serological investigation of q fever in pakistan.		1987	3123737
stimulated arachidonate metabolism during foam cell transformation of mouse peritoneal macrophages with oxidized low density lipoprotein.	changes in arachidonate metabolism were examined in mouse peritoneal macrophages incubated with various types of lipoproteins. oxidized low density lipoprotein (ldl) was incorporated by macrophages and stimulated macrophage prostaglandin e2 (pge2) and leukotriene c4 syntheses, respectively, 10.8- and 10.7-fold higher than by the control. production of 6-keto-pgf1 alpha, a stable metabolite of prostacyclin, was also stimulated. no stimulation was found with native ldl, which was minimally incorpo ...	1988	3125226
[lithium poisoning with persistent neurological sequelae].	a patient suffering from manic-depressive illness was treated on a long-term basis with lithium carbonate in consistent dosage. in the course of intercurrent q-fever he developed lithium intoxication which led to a severe and, as confirmed by a follow-up examination after 5 years, irreversible cerebellar syndrome as well as a discrete organic mental syndrome. the course of the lithium intoxication itself was exceptional in this patient: the cerebellar symptoms appeared very early during the into ...	2011	3125605
increased lactate in cerebrospinal fluid from 7 siblings in a family with mitochondrial myopathy and cerebellar ataxia.		2011	3126362
an interleukin 2 binding factor in human serum.		1988	3127085
estimation of pyruvate dehydrogenase (e1) activity in human skeletal muscle; three cases with e1 deficiency.	pyruvate dehydrogenase (e1) catalyzes the rate-limiting step of the pyruvate dehydrogenase complex. since e1 activity of human muscle tissue is low, a sensitive method is needed for diagnostic purposes. measurement of 14co2 production from [1-14c]pyruvate provides a specific and sensitive assay for measuring e1 activity. we use as artificial electron acceptor dichlorophenolindophenol (dcpip) instead of the often applied ferricyanide. the method can be applied to small muscle samples obtained by ...	1988	3127087
dopamine receptor stimulating effects of chanoclavine analogues, tricyclic ergot alkaloids, in the brain.	the abilities of tricyclic ergot alkaloids, chanoclavine-i and its analogues, and bromocriptine to stimulate dopamine receptors in the brain were investigated. receptor binding of 3h-spiperone has shown that bromocriptine exhibits clear affinity for this compound. the order of displacement potencies was bromocriptine much greater than ergometrine, ksu-1415 greater than chanoclavine-i, ksu-1118, ksu-1791. in the striatum of mice treated with an amino acid decarboxylase inhibitor, gamma-butyrolact ...	1987	3127619
[expression of beta-galactosidase in recombinant nonintegrated plasmids in evaluating the functional activity of vaccinia virus promoters].	the recombinant plasmids pvl1 and pvl2 were constructed for insertion and expression of alien genetic information in hindiii-f fragment of vaccinia virus dna under the control of the strong early-late promoter of the protein 7.5. the late promoter of the main late protein 11k of vaccinia virus was cloned. these as well as other vector plasmids have been used to express the procaryotic beta-galactosidase gene. functional activity of the genetic engineering constructions was estimated by transitor ...	1987	3127696
intravenous indomethacin for postoperative pain. a double-blind study of ankle surgery.	intravenous indomethacin infusion (75 mg/10 h) for relief of pain after ankle surgery was compared with placebo in a double-blind study. ninety-seven patients were operated on for a malleolar fracture or ruptured ligament of the ankle under single-dose spinal anesthesia. in the indomethacin group, 14 out of 49 patients were free from pain, 4/47 in the control group. severe pain was experienced by 24/49 in the indomethacin group and by 41/47 in the control group. supplementary intramuscular oxyco ...	2011	3128054
effect of nitroglycerin on myocardial collateral conductance in awake dogs.	conductance of the coronary collateral circulation during the course of two abrupt circumflex coronary occlusions (pre- and posttreatment with nitroglycerin) was measured in awake dogs approximately 2 wk after collateral vessels were stimulated to develop. the pressure gradient from the central aorta to the distal circumflex coronary artery was measured, and myocardial blood flow was determined by 9-microns radioactive microspheres at 30 s and 4 min after coronary occlusions. collateral conducta ...	1988	3128122
bilateral primary breast cancer in patients treated with adjuvant therapy.	between 1974 and 1986, 1036 patients with operable breast cancer were treated with doxorubicin-containing combination chemotherapy regimens. of these, 44 patients had bilateral breast cancer prior to initiation of adjuvant therapy (prechemotherapy) and 17 patients developed primary breast cancer on the contralateral side during or after completion of adjuvant therapy (postchemotherapy). the objectives of the study were twofold: to determine the incidence of bilateral primary breast cancer and to ...	2011	3128945
[the spinal primary sensory neuron].		1988	3129005
acute traumatic spinal cord injury surveillance--united states, 1987.		2011	3129643
nutritional assessment in a surgical practice.		2011	3131063
effects of growth hormone-releasing hormone and corticotropin-releasing hormone on the release of thyrotropin-releasing hormone from the rat hypothalamus in vitro.	effects of growth hormone-releasing hormone (grh) and corticotropin-releasing hormone (crh) on the release of immunoreactive thyrotropin-releasing hormone (ir-trh) from the rat hypothalamus in vitro were studied. the rat hypothalamus was incubated in medium 199 with 1.0 mg/ml of bacitracin (ph 7.4) for 20 min. the amount of ir-trh release into the medium was measured by radioimmunoassay. the ir-trh release from the rat hypothalamus was inhibited significantly in a dose-related manner with the ad ...	1987	3131150
single dose ciprofloxacin for the eradication of pharyngeal carriage of neisseria meningitidis.	single dose oral ciprofloxacin was given to all personnel in a naval training establishment as part of the management of an outbreak of meningococcal meningitis. two thousand one hundred personnel received the drug and neisseria meningitidis was eradicated from the pharynx of 97% of 570 who were swabbed two to four days later. in a cohort of 277 personnel who were followed for up to nine weeks, pharyngeal carriage was eliminated from 93% of 104 carriers. the overall prevalence of carriage fell f ...	1988	3132442
effect of acclimation and fixation temperatures on the number of lamellae and periodicity of myelin in fibres of the optic nerve of goldfish.	previous findings from our laboratory have shown that the optic nerves of goldfish acclimated to different temperatures differ considerably in their glycerophospholipid composition. this paper describes changes in the morphology of the nerve with different acclimation and fixation temperatures. optic nerves of 5 and 25 degrees c acclimated fish were excised and fixed at the temperature of acclimation, or at the reverse temperature, and the morphology observed by electron microscopy. under all te ...	2011	3139440
further serological investigations in humans and domestic animals on the cape verde islands (q-fever, brucellosis, listeriosis, shigellosis, campylobacteriosis, yersiniosis, toxoplasmosis and chlamydia of plt-group).	439 sera of domestic animals and various number (150-500) of human sera of the cape verde islands were examined for antibodies against coxiella burnetti, brucella abortus, b.melitensis, listeria monocytogenes, shigella dysenteriae, s.flexneri, s. boydii, s.sonnei, campylobacter jejuni, c.fetus ssp. intestinalis, yersinia enterocolitica, toxoplasma gondii and chlamydia of the plt-group. it could be shown, that on the cape verde islands there is to be counted with numerous zoonoses due to various ...	1988	3139491
serological examinations of slaughtered animals (cattle and goats) in the slaughter-house of colombo/sri lanka towards antibodies against brucellosis, q-fever, rmsf-rickettsia-group, listeriosis, echinococcosis and adenoviruses.	serological examinations of slaughtered animals (76 cattle and 184 goats) in the slaughter-house of colombo/sri lanka revealed antibodies against listeriosis, brucellosis, q-fever, rmsf-rickettsia-group, echinococcus and adenoviruses. as the results show, part of this zooanthroponosis has a role to play in human medicine and human infections are to be expected.	1988	3139493
the role of t cell--macrophage interactions in tuberculosis.	acquired resistance against tuberculosis paradigmatically depends on specific t lymphocytes and mononuclear phagocytes. the etiological agent, mycobacterium tuberculosis is capable of replicating in mononuclear phagocytes which act both as habitat and as effectors of protection. upon interaction with antigen-specific t lymphocytes infected mononuclear phagocytes acquire tuberculostatic activities. here, data from experimental tuberculosis studies in mice are summarized which show that: interleuk ...	1988	3146818
pituitary apoplexy.		2011	3147059
"paradoxical" analgesia induced by naloxone and naltrexone.	analgesic effects of pellet implantation of the opiate antagonists naloxone and naltrexone and of chronic administration of naloxone by subcutaneous injection were examined. rats were implanted with a slow-release pellet containing 10 mg naloxone or 10 mg naltrexone and tested for paw-lick latency on a hotplate apparatus. controls were implanted with placebo pellets or given saline injections as appropriate. there were five test trials at intervals up to 72 h after implantation of naloxone and u ...	1988	3147475
antischistosomal treatment and the measurement of incidence of schistosomiasis in a community of high transmission.	there is disagreement in the measurement of incidence in schistosomiasis concerning which of two categories of negatives is representative of the population of an endemic area: naturally uninfected individuals (untreated negatives) and those made negative following treatment (treated negatives). the incidence of schistosomiasis was studied in the two categories of negatives for two periods among 208 school children (6-11 years old) living in a community of high transmission in zimbabwe. in both ...	1988	3147550
erosive pustular dermatosis of the scalp presenting as herpes zoster.		2011	3147771
the population dynamics of two vertically transmitted infections.	the transmission of keystone virus in the mosquito aedes atlanticus and of rickettsia rickettsii in the tick dermacentor andersoni is modeled and analyzed. both of these infections can be transmitted vertically from an infective parent to newborn offspring as well as horizontally via direct or indirect contacts with infected individuals. the vertical transmission mechanism plays a major role in the maintenance of these infections and its effects are analyzed in detail. this same mechanism can ac ...	1988	3148206