Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
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| cold pressure test producing coronary spasm, coronary thrombosis and myocardial infarction in a patient with igm antibodies against coxsackie b virus. | several lines of evidence have shown that viral infections are capable of causing coronary spasm and precipitating or mimicking clinical myocardial infarction. here we report the case of a 41-year-old woman with recurrent angina who was admitted to our hospital because of ventricular tachycardia. laboratory examination revealed positive igm titers against coxsackie b virus. coronary angiography showed normal coronary arteries, but following a cold pressure test severe spasm of all coronaries wit ... | 1999 | 10844390 |
| [therapy and prognosis of infectious complete atrioventricular block in children]. | from 1983 to 1997, we have studied ten children with complete atrioventricular block likely due to myocarditis in order to assess its prognosis and to define a therapeutic strategy. their age ranged from 6 days to 16 years (median: 4.1 years). all were admitted for sudden complete block, with symptoms in seven: syncope or fainting, seizures, collapse. three had an asymptomatic bradycardia which was detected on routine auscultation in children with fever or already hospitalized; fever was present ... | 2000 | 10858852 |
| coxsackievirus infection of the pancreas: evaluation of receptor expression, pathogenesis, and immunopathology. | coxsackievirus type b (cvb) infection of the pancreas induces a massive cellular infiltrate composed of natural killer cells, t cells, and macrophages and leads to the destruction of exocrine tissue. the physiological manifestations of pancreatic cvb infection are correlated with viral tropism; the virus infects acinar cells but spares the islets of langerhans. here we evaluate the mechanisms underlying pancreatic inflammation and destruction and identify the determinants of viral tropism. t-cel ... | 2000 | 10860882 |
| aloe polymannose enhances anti-coxsackievirus antibody titres in mice. | aloe polymannose (ap), a high mannose biological response modifier (brm) purified from the aloe barbadensis miller plant, was tested for activity in enhancing antibody titres against coxsackievirus b3 (cvb3) and cvb3-induced myocarditis in murine models of the disease. inoculation of mice with ap over a range of three nontoxic doses and in varying schedules did not reduce virus titres in heart tissues or ameliorate virus-induced cardiopathological alterations during acute disease. however, this ... | 2000 | 10861969 |
| development and evaluation of quantitative-competitive pcr for quantitation of coxsackievirus b3 rna in experimentally infected murine tissues. | a method is described for quantitation of enterovirus rna in experimentally infected murine tissues. viral rna was extracted from tissue samples and amplified by reverse transcriptase pcr in the presence of an internal standard rna. the ratio of pcr product derived from viral rna and internal standard rna was then determined using specific probes in a post-pcr electrochemiluminescent hybridization assay. this provided an estimate of the viral rna copy number in the original sample, and detection ... | 1999 | 10894631 |
| coxsackie b virus-induced autoimmunity to gad does not lead to type 1 diabetes. | 2000 | 10895859 | |
| molecular pathology and structural features of enteroviral replication. toward understanding the pathogenesis of viral heart disease. | enteroviruses of the picornaviridae and primarily coxsackieviruses of group b (cvb) can be detected in humans and various experimental murine models of acute myocarditis and chronic heart muscle diseases indicating enterovirus persistence in the myocardium. persistent myocardial infection is characterized by restricted viral replication and gene expression in myocytes capable of sustaining chronic inflammation. viral cytotoxicity was found to be crucial for organ pathology both during acute and ... | 2000 | 10904841 |
| enteroviral and immune mediated myocarditis in scid mice. | severe combined immune deficiency (scid) mice have been used as an animal model to study both the direct cytopathic effect of enteroviruses on the heart in the absence of an effective immune system and to investigate the role of immune mediated processes in the pathogenesis of human myocarditis. the infection of scid mice with coxsackievirus b3 resulted in severe myocarditis with very high titers of the virus in the myocardium and severe necrosis of myocytes. this direct cytopathic effect caused ... | 2000 | 10904845 |
| the outcome of coxsackievirus b3-(cvb3-) induced myocarditis is influenced by the cellular immune status. | mice develop a marked age-related susceptibility to myocardial coxsackievirus b3 (cvb3) infections. the lesions observed in mice resemble closely those seen in the human disease. experimental murine models of cvb3-induced myocarditis have shown that both, host and viral genetic factors, can influence susceptibility to the infection as well as the persistence and progression of the disease. recently, we have shown that cd4 t cell-deficient mhc class ii knockout mice develop a strong fibrosis with ... | 2000 | 10904846 |
| expression of inducible nitric oxide synthase in experimental viral myocarditis. | nitric oxide (no) is an important bioactive molecule with regulatory, cytotoxic or cytoprotective properties. in virus-induced myocarditis, no mediates host defense mechanisms against the infection or causes cardiac dysfunctions. no is synthesized from l-arginine by the enzyme nitric oxide synthase (nos). the expression of the inducible form of the nitric oxide synthase (inos) is regulated by cytokines, involved in the complex myocardial immune response to enterovirus infections. the present stu ... | 2000 | 10904848 |
| initial interactions of subgenus d adenoviruses with a549 cellular receptors: sialic acid versus alpha(v) integrins. | selected members of the adenovirus family have been shown to interact with the coxsackie adenovirus receptor, alpha(v) integrins, and sialic acid on target cells. initial interactions of subgenus d adenoviruses with target cells have until now been poorly characterized. here, we demonstrate that adenovirus type 8 (ad8), ad19a, and ad37 use sialic acid as a functional cellular receptor, whereas the ad9 and ad19 prototypes do not. | 2000 | 10906228 |
| redistribution of accumulated 2,3,7,8-tetrachlorodibenzo-p-dioxin during coxsackievirus b3 infection in the mouse. | the tissue redistribution of accumulated 2,3,7, 8-tetrachlorodibenzo-p-dioxin (tcdd) during infection was studied in adult male a/j mice using a common human virus coxsackievirus b3. before infection (day 1), all mice were injected intraperitoneally (i.p.) with 1 microci 3h-tcdd, corresponding to 0.5 microg tcdd kg(-1). one group was sacrificed before virus inoculation (day 0). of the remaining mice, one subgroup was inoculated i.p. with cb3 virus while the other subgroup served as a noninfected ... | 2000 | 10906430 |
| nosocomial transmission of echovirus 30: molecular evidence by phylogenetic analysis of the vp1 encoding sequence. | we investigated six cases of enterovirus infection in a neonatal unit. the index patient, a 5-day-old boy, was admitted with aseptic meningitis due to echovirus 30 (e30). secondary infections with e30 occurred in five babies. comparison of the complete vp1 sequences showed that the isolates recovered from the index patient and his mother were closely related to those recovered from the five babies with secondary infections, demonstrating a nosocomial transmission of the virus. in the phylogeneti ... | 2000 | 10921945 |
| t-cell responses to enterovirus antigens in children with type 1 diabetes. | enterovirus infections, implicated in the pathogenesis of type 1 diabetes in a number of studies, may precipitate the symptoms of clinical diabetes and play a role in the initiation of the beta-cell damaging process. the aim of this study was to evaluate whether cellular immune responses to enterovirus antigens are abnormal in children with type 1 diabetes. lymphocyte proliferation responses to enterovirus antigens were analyzed in 41 children with new-onset type 1 diabetes, 23 children with typ ... | 2000 | 10923630 |
| coxsackievirus expression of the murine secretory protein interleukin-4 induces increased synthesis of immunoglobulin g1 in mice. | we cloned the sequence encoding murine interleukin-4 (mil-4), including the secretory signal, into the genome of cvb3/0, an artificially attenuated strain of coxsackievirus b3, at the junction of the capsid protein 1d and the viral protease 2apro. two strains of chimeric cvb3 were constructed using, in one case, identical sequences to encode 2apro cleavage sites (cvb3/0-mil4/47) on either side of the inserted coding sequence and, in the other case, nonidentical sequences that varied at the nucle ... | 2000 | 10933703 |
| group b coxsackievirus myocarditis and pancreatitis: connection between viral virulence phenotypes in mice. | the group b coxsackieviruses (cvb) induce experimental pancreatitis and myocarditis in mice and are established agents of human myocarditis, especially in children. we tested the hypothesis that the development of cvb-induced myocarditis is linked to cvb-induced pancreatitis by studying the replication of different cvb strains in mice. eight of nine genotypically different type 3 cvb (cvb3) strains induced acute pancreatitis in mice; of these, three viruses also induced acute myocarditis. one cv ... | 2000 | 10935991 |
| t-cell reactivity to the p2c nonstructural protein of a diabetogenic strain of coxsackievirus b4. | enteroviruses are proposed as initiating factors in the etiology of type 1 diabetes mellitus (type 1 dm). molecular mimicry between the autoantigen glutamic acid decarboxylase 65 (gad65) and the coxsackievirus b4 (cvb4) nonstructural protein p2c is frequently cited as a mechanism by which this virus triggers the disease, but little is known about the immunogenicity of this viral protein in humans, mainly due to the problem of obtaining highly pure preparations of p2c. we generated large amounts ... | 2000 | 10936088 |
| singleton reactors in the diagnosis of swine vesicular disease: the role of coxsackievirus b5. | swine vesicular disease virus (svdv) and coxsackie b5 virus (cvb5) are closely related viruses that can infect swine and man and give rise to cross-reacting serum antibodies. it is, therefore, possible that svd antibodies found in serologic screenings of pigs are induced by cvb5. single positive animals found in screening programmes are generally referred to as singleton reactors (sr). to determine whether sr in svdv screenings are induced by cvb5 infection, virus neutralisation tests (vnts) and ... | 2000 | 10973703 |
| antiviral effect of the combination of enviroxime and disoxaril on coxsackievirus b1 infection. | effects of enviroxime and disoxaril, inhibitors of replication of some picornaviruses with known mechanisms of action, alone or in combination, on replication of coxsackievirus b1 (cvb1) in fl cells and on experimental cvb1 infection in newborn mice were tested. the combination of enviroxime and disoxaril resulted in vitro in a synergistic interaction. both compounds were administered in vivo, alone or in combination, daily by subcutaneous (s.c.) route since the day of virus inoculation till the ... | 2000 | 10989697 |
| early alteration of nucleocytoplasmic traffic induced by some rna viruses. | a hela cell line expressing the green fluorescent protein fused to the sv40 t-antigen nuclear localization signal (egfp-nls) was established. fluorescence in these cells was confined to the nuclei. after poliovirus infection, cytoplasmic fluorescence in a proportion of cells could be detected by 1 h postinfection (p.i.) and in virtually all of the fluorescent cells by 2 h p.i. the relocation could be prevented by cycloheximide but not by inhibition of poliovirus replication by guanidine. hcl. nu ... | 2000 | 10998323 |
| attachment of coxsackievirus b3 variants to various cell lines: mapping of phenotypic differences to capsid protein vp1. | the coxsackievirus b3 (cvb3) strain nancy p establishes a persistent carrier-state infection without visible cytopathic effect in primary human fibroblasts (hufi h), whereas the derivative variant pd induces a complete lysis of the cell monolayer. to define the molecular basis of this exceptional growth property, the complete genomes of both viruses were sequenced and compared to all published sequences of cvb3. as a result, six unique amino acid substitutions in the vp1 capsid protein were obse ... | 2000 | 11017789 |
| persistent infection of human pancreatic islets by coxsackievirus b is associated with alpha interferon synthesis in beta cells. | the interactions of coxsackievirus b3 (cvb3), cvb4e2 (diabetogenic), and cvb4jbv (nondiabetogenic) strains with human pancreatic islets from eight adult brain-dead donors were investigated. persistent replication of viruses in human islets was proved by detection of viral rna by in situ hybridization, vp1 capsid protein by immunofluorescence (if) staining, negative-strand viral rna by reverse transcription-pcr in extracted rna from islets, and release of infectious particles up to 30 days after ... | 2000 | 11024144 |
| v gamma 1+ t cells suppress and v gamma 4+ t cells promote susceptibility to coxsackievirus b3-induced myocarditis in mice. | coxsackievirus b3 infections of c57bl/6 mice, which express the mhc class ii ia but not ie ag, results in virus replication in the heart but minimal myocarditis. in contrast, bl.tg.ealpha mice, which are c57bl/6 mice transgenically induced to express ie ag, develop significant myocarditis upon coxsackievirus b3 infection. despite this difference in inflammatory damage, cardiac virus titers are similar between c57bl/6 and bl.tg.ealpha mice. removing gammadelta t cells from either strain by geneti ... | 2000 | 11035049 |
| quantitative analysis of viral rna kinetics in coxsackievirus b3-induced murine myocarditis: biphasic pattern of clearance following acute infection, with persistence of residual viral rna throughout and beyond the inflammatory phase of disease. | although the association remains controversial, enteroviruses have been implicated in the aetiology of several chronic diseases of humans. to further understand the mechanism of enterovirus persistence and its relationship to organ pathology, virus infectivity and viral rna kinetics in the heart and other target organs during acute and persistent phases of murine coxsackievirus b3 infection were investigated. these studies revealed a biphasic pattern of virus clearance. thus, there was a rapid b ... | 2000 | 11038389 |
| trace element changes in the myocardium during coxsackievirus b3 myocarditis in the mouse. | during most infections plasma, concentrations of trace elements change, but it is unclear if this reflects changes in infected target tissues. in coxsackievirus b3 (cb3) infection, the myocardium is a target in both humans and mice. the concentrations of 12 trace elements were analyzed by inductively coupled plasma-mass spectrometry (icp-ms) in the myocardium of sham-inoculated controls and infected a/j mice 4 and 7 d postinoculation. the size of the inflammatory lesion was positively correlated ... | 2000 | 11049229 |
| acute onset of type i diabetes mellitus after severe echovirus 9 infection: putative pathogenic pathways. | enterovirus infections have been implicated in the development of type i diabetes mellitus. they may cause beta cell destruction either by cytolytic infection in the pancreas or indirectly by contributing to autoimmune reactivity. we sought evidence for these 2 mechanisms in a case of acute-onset diabetes mellitus that occurred during severe echovirus 9 infection. the virus was isolated and administered to cultured human beta cells. no viral proliferation was observed, and no beta cell death was ... | 2000 | 11049787 |
| nitric oxide and viral cardiomyopathy. | 2000 | 11056085 | |
| limited proteolysis of the coxsackievirus and adenovirus receptor (car) on hela cells exposed to trypsin. | trypsin treatment of hela cells results in a limited proteolysis of the coxsackievirus and adenovirus receptor (car) after which the cleaved car remains cell-associated and tryptic peptides remain associated through disulfide bonds. trypsin-treated hela cells remain susceptible to infection with coxsackievirus b and produce progeny virus at 8 h post-infection in amounts comparable to cells with intact car. hela cells remove the proteolysed car within 15 h and require over 24 h to restore intact ... | 2000 | 11068050 |
| mutations in a conserved enteroviral rna oligonucleotide sequence affect positive strand viral rna synthesis. | we showed earlier that a transition mutation u234c, located within the completely conserved 5 nucleotide (nt) tract 5'-cguua (nt232-236) in the 5' non-translated region (ntr) of the coxsackievirus b3 (cvb3) genome, attenuated cvb3 cardiovirulence in mice. to further explore the role of the sequence, we induced two single and one double transversion mutations in the conserved 5mer in a cardiovirulent cvb3 genome. the mutated sites partially or totally reverted to parental wild-type when progeny v ... | 2000 | 11087092 |
| sero-surveillance of wild boar in the netherlands, 1996-1999. | from 1996 to 1999, blood samples were collected from wild boar shot during the hunting season in crown properties, national parks and the free wildlife belt in the netherlands. sera were screened for the presence of antibodies against classical swine fever virus (csfv), swine vesicular disease virus (svdv), aujeszky's disease virus (adv) and trichinella spiralis. the results of the sero-surveillance system indicate that csfv, svdv and adv are uncommon within the wild boar population. hence, the ... | 2000 | 11107628 |
| immunogenicity of a foreign peptide expressed within a capsid protein of an attenuated coxsackievirus. | the immunogenicity of soluble peptides can be improved by expression within recombinant microorganisms. the immunogenicity of a peptide expressed within a capsid protein of an attenuated coxsackievirus b4 was evaluated. the insertion site was chosen based on its antigenic structure. a foreign peptide was inserted into a region of the vp1 capsid protein that was identified as a t helper cell epitope. a recombinant virus containing ten amino acids of ovalbumin sequence was genetically stable and r ... | 2000 | 11115722 |
| micronutrients and host resistance to viral infection. | previous work in our laboratory demonstrated that a virus could undergo rapid mutation in a host deficient in se, leading to a normally avirulent virus acquiring virulence due to genome changes. once these mutations occur, even a host with adequate se-nutriture is susceptible to the newly virulent virus. what influence does the deficiency in se have on the immune response of the host? infection with myocarditic strains of coxsackievirus induces an inflammatory response in the cardiac tissue. it ... | 2000 | 11115793 |
| cardioselective infection with coxsackievirus b3 requires intact type i interferon signaling: implications for mortality and early viral replication. | interferons (ifns) play an important role in antiviral defense and have therapeutic potential in coxsackievirus heart disease. however, little is known about the relative contributions of type i and type ii ifn signaling in coxsackievirus b3 (cvb3) infection or their role in the cardioselective nature of cvb3 infection. | 2001 | 11156890 |
| decreased immediate inflammatory gene induction in activating transcription factor-2 mutant mice. | transcription factor activating transcription factor (atf)-2 is activated by inflammatory signals transduced by the jnk and p38 map kinase pathways. to better define the role of atf-2 in inflammation, adult mice expressing small amounts of a mutant atf-2 protein were challenged with lipopolysaccharide (lps), anti-cd3 antibody or virus. within 3 h of challenge by lps, atf-2 mutant mice had decreased induction of the adhesion molecules e-selectin, p-selectin and vcam-1 as well as the cytokines tum ... | 2001 | 11157857 |
| using recombinant coxsackievirus b3 to evaluate the induction and protective efficacy of cd8+ t cells during picornavirus infection. | coxsackievirus b3 (cvb3) is a common human pathogen that has been associated with serious diseases including myocarditis and pancreatitis. to better understand the effect of cytotoxic t-lymphocyte (ctl) responses in controlling cvb3 infection, we have inserted well-characterized ctl epitopes into the cvb3 genome. constructs were made by placing the epitope of interest upstream of the open reading frame encoding the cvb3 polyprotein, separated by a poly-glycine linker and an artificial 3cpro/3cdp ... | 2001 | 11160741 |
| antiviral and antiproliferative activity in vitro of some new benzimidazole derivatives. | the antiviral and antiproliferative activity of new compounds having n-benzenesulphony 1-2 (2 or 3-pyridylethyl) benzimidazole as a base structure were studied in vitro. their antitumour activity against human chronic myeloid leukaemia cells was evaluated and compared with that of equimolar doses of daunorubicin. only compound 7a, with the presence of both the pyridyl moiety bound at the ethylenic bridge in c-2 of benzimidazole and the nitro-group in the benzene ring, displays a selective antipr ... | 2001 | 11169164 |
| differences in inhibition of replication between coxsackie b4 virus strains in various cell lines by antibodies to some cell surface proteins. | monoclonal antibodies that interact with the decay accelerating factor (daf, cd55), the lymphocyte homing receptor (cd44) or the intercellular adhesion molecule i (icam- 1) were found to inhibit the replication of different strains of coxsackievirus serotype b4 (cbv-4) to various extent. by adding antibodies to cd55 the replication of two (v345 and vd2921) of seven strains in hela cells, three (v89-4557, vd2921 and t318) of seven in a549-10c cells and one (vd2921) of five strains in rd cells was ... | 2001 | 11172916 |
| detection of coxsackie b virus infection using a rapid screening method. | a western blot method (wb) was adapted for rapid screening of antibodies against coxsackie virus b1-b6 in sera from patients with newly diagnosed insulin-dependent diabetes mellitus, myocarditis or febrile syndrome of suspected coxsackie viral aetiology. the use of a mixture of all 6 coxsackie virus b serotypes as the common antigen permitted a very rapid and inexpensive detection of antibody-positive sera for preliminary diagnosis and further detailed assay. comparison of the results with those ... | 2000 | 11200674 |
| outbreak of aseptic meningitis by echo 4: prevalence of clinical cases among adults. | twenty five cases of meningitis occurred in urban areas surrounding a city (modena) in northern italy, in the period may-july 1999. when the patients were admitted to the infectious diseases division of the university of modena and reggio emilia hospital and studied by virological and serological methods, the meningitis proved to have an enteroviral origin and enterovirus echo 4 type was responsible for all cases of illness. an epidemiological characteristic of the enteroviral meninigitis outbre ... | 2001 | 11209838 |
| analysis of tcr vbeta repertoire and cytokine gene expression in patients with idiopathic dilated cardiomyopathy. | although the etiopathogenesis of idiopathic dilated cardiomyopathy (idc) is still unclear, it is widely accepted that a complex interplay between viral infections and immune mechanisms is the basis of disease genesis. previously, we showed that heart-infiltrating t cells of patients suffering from acute, fulminant coxsackie virus b3+-idc shared a preferential usage of three variable gene segments of the t cell receptor beta chain-(tcr-vbeta) encoding families vbeta3, 7 and 13.1. this indicated t ... | 2001 | 11221991 |
| [water-borne outbreak of serous meningitis caused by echovirus-30 in belarus]. | in recent years outbreak of enterovirus infections caused by echovirus-30 were rather frequently registered in different european countries. a major outbreak caused by this virus took place during the summer-autumn period of 1997 in the city of gomel, belarus. sanitary epidemiological and molecular epidemiological studies made it possible to determine that the outbreak was water-borne. the sequence analysis of echovirus-30 strains isolated from water and the cerebrospinal fluid of patients revea ... | 2001 | 11236495 |
| [minor bupleurum decoction in the treatment of viral myocarditis models]. | a myocarditis model of balb/c mice established by means of coxsackie virus type b3 was treated with the minor bupleurum decoction. the results indicate that the decoction can regulate t lymphocyte subsets, influence anti-cardiac antibody production, help the organism to get clear of viruses, and thus plays an important role in treating viral myocarditis. | 1997 | 11243188 |
| specific inhibition of coxsackievirus b3 translation and replication by phosphorothioate antisense oligodeoxynucleotides. | the 5' and 3' untranslated regions (utrs) of coxsackievirus b3 (cvb3) rna form highly ordered secondary structures that have been confirmed to play important regulatory roles in viral cap-independent internal translation initiation and rna replication. we previously demonstrated that deletions in different regions of the 5' utr significantly reduced viral rna translation and infectivity. such observations suggested strongly that viral rna translation and replication could be blocked if highly sp ... | 2001 | 11257014 |
| identification of echovirus 1 and coxsackievirus a9 receptor molecules via a novel flow cytometric quantification method. | background: virus-receptor binding is an essential step in every virus infectious process. many viruses employ more than one receptor molecule or even receptor complexes for attachment. in this study, we investigate the binding of echovirus 1 (echo1) and coxsackievirus a9 (cav-9) on cell surface molecules. cav-9 has been reported to utilize integrin alpha v beta(3) in binding to cells, whereas echo1 has been known to utilize integrin alpha 2 beta(1). methods and results we directly test whether ... | 2001 | 11260595 |
| altered expression of bag-1 in coxsackievirus b3 infected mouse heart. | the mechanisms by which coxsackie b viruses cause myocarditis or dilated cardiomyopathy are not well understood. this study examined changes in the expression of cardiac genes resulting from coxsackievirus b3 (cvb3) infection of mice. | 2001 | 11282077 |
| enterovirus infection--a possible trigger for graves' disease? | viruses are potential environmental factors in autoimmune disease. some evidence suggests a relationship between enteroviral infection (especially coxsackie b virus) and autoimmunity. we investigated 21 individuals with recent onset of graves' hyperthyroidism in regard of (subclinical) enterovirus infection. thyrotoxic symptoms had started about two months before blood sample collection. the patients were from upper austria and mainly female (17/21). their mean free thyroxin levels in blood were ... | 2001 | 11293951 |
| rapid production of recombinant allergens in nicotiana benthamiana and their impact on diagnosis and therapy. | type i allergies are immunological disorders that afflict a quarter of the world's population. recombinant allergens have improved the diagnosis of allergic diseases and allow the formulation of new therapeutic approaches. over 50% of all allergens are of plant origin. | 2001 | 11306923 |
| echoviruses bind heparan sulfate at the cell surface. | some echoviruses (ev) that bind decay-accelerating factor (daf) also bind cells of human and murine origins in a daf-independent manner. pretreatment of cells with heparinase 1 or heparin blocks the binding of radiolabeled virus to the cell surface, and heparin prevents infection of rhabdomyosarcoma cells by certain ev, including several low-passage clinical isolates of ev 6 and some ev that do not bind daf. these studies suggest that heparan sulfate may be of in vivo relevance as an attachment ... | 2001 | 11312365 |
| inhibition of coxsackievirus b4 replication in stably transfected cells expressing human mxa protein. | coxsackieviruses b (cvb) (b1-b6), positive-strand rna viruses, cause a variety of diseases. cvb4 may have a causal role in insulin-dependent diabetes mellitus. ifn-alpha inhibits cvb replication; however, the mechanism is not well known. the interferon-alpha-inducible human mxa protein exerts an antiviral activity against negative-strand rna viruses and against semliki forest virus, a positive-strand rna virus. to test the antiviral spectrum of mxa against cvb4, we took advantage of stably trans ... | 2001 | 11312665 |
| trace element distribution in heart tissue sections studied by nuclear microscopy is changed in coxsackie virus b3 myocarditis in methyl mercury-exposed mice. | methyl mercury (mehg) has been shown to change coxsackie virus type b3 (cb3) myocarditis in a direction compatible with the development of chronic disease. murine models of cb3 myocarditis closely mimic the pathogenesis in humans. there are also indications that metals, such as mercury, and trace elements may interact and adversely affect viral replication and development of inflammatory lesions. the effects of low-dose mehg exposure on myocardial trace element distribution, as determined by mea ... | 2000 | 11314973 |
| taurine influx in cultured rat cardiomyocytes and changes after cvb3 infection. | monolayer culture of spontaneously contracting rat heart cells was obtained from newborn sd rats and seeded into culture plates. 100tcid50 of coxsackie virus b3(cvb3) (nancy strain) was added as the infected group. the dynamics of taurine transport across membrane of normal heart cells and changes after infection were examined by using radioactive isotope tracing techniques. the results demonstrated that: (1) two uptake systems of taurine with different affinities and capacities were present in ... | 1997 | 11360626 |
| genetic characterization of the coxsackievirus b2 3' untranslated region. | the secondary structure of the 3' untranslated region (3'utr) of picornaviruses is thought to be important for the initiation of negative-strand rna synthesis. in this study, genetic and biological analyses of the 3' terminus of coxsackievirus b2 (cvb2), which differs from other enteroviruses due to the presence of five additional nucleotides prior to the poly(a) tail, is reported. the importance of this extension was investigated using a 3'utr mutant lacking the five nucleotides prior to the po ... | 2001 | 11369877 |
| echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the vla-2 i domain. | echoviruses (ev) 1 and 8 were originally considered to be distinct serotypes, but more recently have been considered strains of the same virus. in experiments with chimeric recombinant fusion proteins, both viruses bound to the i domain of the integrin vla-2, and both required the same receptor residues for attachment. a full-length, infectious cdna clone encoding ev1 was obtained; its nucleotide sequence was determined, as were the sequences encoding the ev8 capsid. ev1 and 8 show 94% amino aci ... | 2001 | 11376841 |
| a rapid assay for evaluation of antiviral activity against coxsackie virus b3, influenza virus a, and herpes simplex virus type 1. | in order to identify new potential antiviral drugs, small amounts of extracts or compounds have to be examined for cytotoxicity and antiviral activity in primary screening using a rapid, easy, inexpensive, and highly standardised test system. in this study, high-throughput cytopathic effect (cpe) inhibitory assays were established for coxsackie virus b3 on hela ohio cells, influenza virus a on madin-darby canine kidney cells, and herpes simplex virus type 1 (hsv-1) on green monkey kidney cells t ... | 2001 | 11377720 |
| cytokine production by vgamma(+)-t-cell subsets is an important factor determining cd4(+)-th-cell phenotype and susceptibility of balb/c mice to coxsackievirus b3-induced myocarditis. | two coxsackievirus b3 (cvb3) variants (h3 and h310a1) differ by a single amino acid mutation in the vp2 capsid protein. h3 induces severe myocarditis in balb/c mice, but h310a1 is amyocarditic. infection with h3, but not h310a1, preferentially activates vgamma4 vdelta4 cells, which are strongly positive for gamma interferon (ifn-gamma), whereas vgamma1 vdelta4 cells are increased in both h3 and h310a1 virus-infected animals. depletion of vgamma1(+) cells using monoclonal anti-vgamma1 antibody en ... | 2001 | 11390587 |
| host selenium status selectively influences susceptibility to experimental viral myocarditis. | the purpose of the present work was to determine whether dietary selenium (se) deficiency could influence the injurious effect of human viruses other than coxsackie virus b3 (cvb3) on mouse heart. weanling c3h/hen mice were fed a se-deficient or se-adequate diet for 4 wk and then were inoculated intraperitoneally with one of the following viruses: coxsackie virus b1 (cvb1), echovirus 9 (ev9), coxsackie virus a9 (cva9), or herpes simplex 1 (hsv1). polio virus 1 (pv1) was employed as a negative co ... | 2001 | 11393307 |
| bone marrow failure with concurrent enteroviral infection in a newborn. | a newborn baby, with transient pancytopenia concurrent to echovirus type 11 infection, was hospitalized for fever, diarrhea, rash, generalized petechiae and hepatosplenomegaly. subsequent investigation showed bone marrow failure. to our knowledge this is the first reported case of bone marrow failure with concomitant enteroviral infection. | 2001 | 11465851 |
| tissue culture of isolated human pancreatic islets infected with different strains of coxsackievirus b4: assessment of virus replication and effects on islet morphology and insulin release. | the aim was to study whether different strains of coxsackievirus b4 (cbv-4) are able to infect human pancreatic islet cells in vitro and cause morphological and functional damages. isolated islets maintained in tissue culture were infected with five well- characterised strains of cbv-4. aliquots of the culture medium were analysed with regard to virus replication and insulin content. infected and uninfected islets were examined by light microscopy to determine the degree of virus-induced cytopat ... | 2000 | 11467407 |
| an outbreak of echovirus 11 in a children's home. | an outbreak of echovirus 11 infection was observed in a children's home that housed 16 children. nine children younger than 1 year shared a large room on the first floor, which contained a large basin. three of them presented with aseptic meningitis with csf and stool samples positive for echovirus 11. the other six infants who shared the room were asymptomatic but their stools were positive for echovirus 11. seven infants aged 1-2 years stayed on the second floor and were asymptomatic. one of t ... | 2001 | 11467801 |
| suppression of proinflammatory cytokines and induction of il-10 in human monocytes after coxsackievirus b3 infection. | coxsackievirus b3 (cvb3) causes acute and chronic myocarditis, which is accompanied by an intense mononuclear leukocyte infiltration. because myocardial tissue damage may either result from viral infections or from a dysregulated immune response, the susceptibility of human monocytes and macrophages to cvb3 was examined in this study with regard to virus replication, virus persistence, and release of cytokines. monocytes were infected by cvb3 as shown by the intracellular appearance of plus- and ... | 2001 | 11468734 |
| [detection of coxsackie b virus igm antibody in myocarditis patients by mac elisa]. | to detect coxsackie b virus type 1-6 igm antibodies from 193 clinically diagnosed myocarditis cases. | 2000 | 11471030 |
| [detection of viral aetiology in cerebral spinal fluid samples from 580 clinical cases]. | to investigate the viral aetiology in cerebral spinal fluid (csf) from 580 cases of cns infection or fuo in yuedong district from 1990 to 1997. | 2000 | 11471031 |
| [experimental study on inhibitory effect of ganlu xiaodu dan on coxackie virus in vitro]. | to observe the coxackie virus inhibitory effect of ganlu xiaodu dan (glxdd), including complete recipe, incomplete recipe and supplemented recipe of it. | 1998 | 11475722 |
| [experimental study on treatment of viral myocarditis in mice by integrated traditional chinese and western medicine]. | to clarify the effects of astragalus membranaceus (am) combined with taurine and/or coenzyme q10(coq10) on coxsackievirus b3 (cvb3) murine myocarditis. | 1998 | 11477833 |
| [experimental study on therapeutical effect of chinese medicine on polymyositis in guinea pigs]. | to study the therapeutical effects of radix bupleuri and ramulus cinnamomi on virus polymyositis in guinea pigs. | 1998 | 11477912 |
| expression of immunoregulatory cytokines by recombinant coxsackievirus b3 variants confers protection against virus-caused myocarditis. | clinical and laboratory investigations have demonstrated the involvement of viruses and bacteria as potential causative agents in cardiovascular disease and have specifically found coxsackievirus b3 (cvb3) to be a leading cause. experimental data indicate that cytokines are involved in controlling cvb3 replication. therefore, recombinant cvb3 (cvb3rec) variants expressing the t-helper-1 (t(h)1)-specific gamma interferon (ifn-gamma) or the t(h)2-specific interleukin-10 (il-10) as well as the cont ... | 2001 | 11483764 |
| isolation of coxsackievirus b5 from pigs. | a cytopathic virus was isolated from young pigs suffering from severe diarrhea in okinawa, japan in 1986. the disease was highly contagious among young pigs. the physico-chemical properties of the virus indicated an enterovirus, but, no of serological relationship was detected with reference strains of porcine enteroviruses. with the aid of genbank for genomic sequence data, rt-pcr and hybridization method was performed. the viral isolate was identified as the coxsackievirus (cv) b5 of human ent ... | 2001 | 11497077 |
| [study on the inhibitory effect of antisense phosphorothioate oligodeoxynucleotide on coxsackie virus b replication in vitro]. | to investigate the antiviral effect of antisense phosphorothioate oligodeoxynucleotide (aodn) on cvb3 replication in vitro. | 2000 | 11498691 |
| [effect of sophora flavescens ait on cultured beating myocardial cells of coxsackie b3 virus infected newborn rat]. | coxsackie b viruses (cvb3) are considered to be the most common etiologic agents of viral myocarditis. there are not any special anti-cvb3 drugs yet. from previous studies, the anti-cvb3 affect of sophora flavescens ait (sfa) had been discovered. our experiment was to study the anti-cvb3 ability of sfa to cultured heating myocardial cells of cvb3 infected newborn rat. | 2000 | 11503044 |
| viral water contamination as the cause of aseptic meningitis outbreak in belarus. | in the recent years echovirus-30 associated outbreaks have taken place in different european countries. aseptic meningitis caused by echovirus-30 was the main diagnosis of a large outbreak in belarus in summer-autumn, 1997, involving 460 patients. echovirus-30 was detected in cerebrospinal fluid of the patients with aseptic meningitis. this serotype played the dominant role in the outbreak. minor serotypes and mixtures of enteroviruses were detected in faeces and nasopharyngeal lavages. investig ... | 2001 | 11505740 |
| t cell activation by coxsackievirus b4 antigens in type 1 diabetes mellitus: evidence for selective tcr vbeta usage without superantigenic activity. | numerous clinical and epidemiological studies link enteroviruses such as the coxsackie virus group with the autoimmune disease type 1 diabetes mellitus (dm). in addition, there are reports that patients with type 1 dm are characterized by skewing of tcr vbeta chain selection among peripheral blood and intraislet t lymphocytes. to examine these issues, we analyzed tcr vbeta chain-specific up-regulation of the early t cell activation marker, cd69, on cd4 t cells after incubation with coxsackieviru ... | 2001 | 11544345 |
| persistent expression of cytokines in the chronic stage of cvb3-induced myocarditis in nmri mice. | coxsackievirus b3 (cvb3)-induced myocarditis in nmri mice represents a model for studying the pathogenesis of this chronic heart disease. previously, we reported on specific cytokine patterns during the acute stage of myocarditis since cytokines are thought to play the important role in this cardiomyopathy. in this study, the expression of various cytokine mrnas and cvb3-rna kinetics was examined with particular emphasis on the late phase of myocarditis, by using reverse transcriptase-polymerase ... | 2001 | 11549341 |
| [coxsackie b viral infection in the etiology and clinical pathogenesis of psoriasis]. | the data submitted point to the importance of the enteroviral infection, in particular, coxsackie' b vira in the pathogenesis of many non-infectious diseases. our studies explore the possibility for the coxsackie b virus involvement in the etiopathogenesis of psoriasis. 25 examined patients with psoriasis revealed in 100% of cases antibodies to the coxsackie b virus in diagnostic titres, with a number of patients having displayed a progressive increase in the titres of the above antibodies, whic ... | 2001 | 11560028 |
| poliovirus surveillance by examining sewage specimens. quantitative recovery of virus after introduction into sewerage at remote upstream location. | in order to assess the feasibility of environmental poliovirus surveillance, known amounts of poliovirus type 1, strain sabin, were flushed into the sewage network of helsinki. grab specimens collected at a remote downstream location and concentrated about a 100-fold revealed infectious poliovirus on four successive days in all three separate experiments. as for concentration, a simple two-phase separation method was found to be at least as useful as a several-fold more resource-demanding polyet ... | 2001 | 11561962 |
| [significance of congenital mixed viral infection in the pathogenesis of retinopathy of prematurity]. | forty-three infants aged 1-5 months with somatic and neurological diseases, including congenital, 18 of these with retrolental fibroplasia (rf) and 25 without rf were examined. control group consisted of 36 age-matched infants. based on identification of viral antigens in urine precipitate cells, mixed viral infection was diagnosed in 100% patients and 16.6% healthy babies. ophthalmotropic echo 11 and 19 viruses were detected in 100% patients with rf, 28% patients without rf, and 10% healthy bab ... | 2001 | 11569172 |
| interaction of coxsackievirus b3 with the full length coxsackievirus-adenovirus receptor. | group b coxsackieviruses (cvb) utilize the coxsackievirus-adenovirus receptor (car) to recognize host cells. car is a membrane protein with two ig-like extracellular domains (d1 and d2), a transmembrane domain and a cytoplasmic domain. the three-dimensional structure of coxsackievirus b3 (cvb3) in complex with full length human car and also with the d1d2 fragment of car were determined to approximately 22 a resolution using cryo-electron microscopy (cryo-em). pairs of transmembrane domains of ca ... | 2001 | 11573093 |
| the replication of certain coxsackie b virus strains in cho cells. | cell surface molecules that can act as viral receptors may exert an important selective pressure on rna viral quasi-species. coxsackie-adenovirus receptor and decay accelerating factor (daf, cd55) have been identified as receptors for coxsackie b virus. in studies of viral replication using different strains of coxsackievirus serotype 4 (cbv-4), it was found that despite lack of expression of these cell surface molecules on chinese hamster ovary (cho) cells and despite their common use as negati ... | 2001 | 11576643 |
| aseptic meningitis in germany associated with echovirus type 13. | echoviruses are the commonest cause of aseptic meningitis. echovirus type 13 which has not been isolated in germany over a long period of time was the predominant enterovirus serotype associated with different local outbreaks of aseptic meningitis in germany in 2000. | 2001 | 11591222 |
| a-549 is a suitable cell line for primary isolation of coxsackie b viruses. | a common receptor for coxsackie b virus and adenovirus has been described recently in cells of human and murine origin. since the established cell line a-549 is suitable for adenoviruses, the potential use of a-549 cells for the isolation of coxsackie b viruses from clinical samples was investigated. all throat swabs sent to the laboratory between april 1998 and june 1999 were inoculated onto monolayers of mrc-5 and a-549 cells in tubes, and the enterovirus isolates obtained were typed. from apr ... | 2001 | 11596090 |
| virulence of swine vesicular disease virus is determined at two amino acids in capsid protein vp1 and 2a protease. | to identify the genetic determinants of virulence for swine vesicular disease virus, a panel of recombinant and site-directed mutant viruses were constructed from cdna clones of a virulent j1'73 strain and an avirulent h/3'76 strain. initial studies mapped the genetic determinants of virulence to either or both of the two sites at nucleotide (nt) 2842, encoding vp1-132, and nt 3355, encoding 2a-20. to determine their relative importance with regard to virulence, viruses mutated at either of thes ... | 2001 | 11597755 |
| antibody-dependent enhancement of coxsackievirus b4 infectivity of human peripheral blood mononuclear cells results in increased interferon-alpha synthesis. | igg devoid of neutralizing activity and isolated from donor plasma by chromatography formed immune complexes with coxsackievirus b4 (cvb4) and significantly increased the infection of peripheral blood mononuclear cells with cvb4. the major host cells for cvb4 infection enhanced with igg are monocytic cd14+ cells. the roles of cvb and adenovirus receptor and fcgamma receptor ii and iii have been shown. increased viral replication and the release of infectious particles were demonstrated when inte ... | 2001 | 11598831 |
| an outbreak of aseptic meningitis due to echo 30 virus in romania during the 1999 summer. | between april-september 1999 an unusually high number of acute aseptic meningitis was reported in six north eastern counties of romania. at the end of 1999 summer the epidemic area extended in south romania including the capital city bucharest. the total number of cases surpassed 5500. the majority of confirmed cases were young children under 15 years of age. more than 1800 cases were registered in the same interval in the neighboring republic of moldavia. we report the isolation of echo 30 viru ... | 1999 | 11601385 |
| the apoptotic capability of coxsackievirus b3 is influenced by the efficient interaction between the capsid protein vp2 and the proapoptotic host protein siva. | infections with coxsackievirus b3 (cvb3) are common causes of myocarditis in humans. one detail of cvb3-induced pathogenesis is apoptosis. the interaction between the capsid protein vp2 of the myocardial virus variant cvb3h3 and the proapoptotic host cell protein siva has recently been observed. in order to characterize the interaction between both proteins more precisely, the binding activity of the cvb3h3 vp2 to siva was compared to that of the mutant virus cvb3h310a1 vp2. we found that the as ... | 2001 | 11601913 |
| an attenuating mutation in the 2a protease of swine vesicular disease virus, a picornavirus, regulates cap- and internal ribosome entry site-dependent protein synthesis. | virulent and avirulent strains of swine vesicular disease virus (svdv), a picornavirus, have been characterized previously. the major determinants for attenuation have been mapped to specific residues in the 1d-2a-coding region. the properties of the 2a proteases from the virulent and avirulent strains of svdv have now been examined. both proteases efficiently cleaved the 1d/2a junction in vitro and in vivo. however, the 2a protease of the avirulent strain of svdv was much less effective than th ... | 2001 | 11602706 |
| comparison of the complete nucleotide sequences of echovirus 7 strain ummc and the prototype (wallace) strain demonstrates significant genetic drift over time. | the complete nucleotide sequences are reported of two strains of echovirus 7, the prototype wallace strain (eo7-wallace) and a recent malaysian strain isolated from the cerebrospinal fluid of a child with fatal encephalomyelitis (eo7-ummc strain). the molecular findings corroborate the serological placement of the ummc strain as echovirus 7. both eo7-wallace and eo7-ummc belong to the species human enterovirus b and are most closely related to echovirus 11. eo7-ummc has undergone significant gen ... | 2001 | 11602774 |
| t cell-mediated immune response enhances the severity of myocarditis in secondary cardiotropic virus infection in mice. | in this report, we showed that a previous enterovirus exposure in ordinary mice with normal t cell function, but not in t cell-deficient mice, can influence development of myocardial inflammation with a second virus exposure. inoculation of 4-week-old male balb/c-nu/+ (euthymic and normal t cell function) mice with amyocarditic coxsackie virus b1 (cb1), followed by inoculation 28 days later with myocarditic variant of coxsackie virus b3 (cb3-m) resulted in more intense myocardial inflammation an ... | 2001 | 11605990 |
| swine vesicular disease virus. pathology of the disease and molecular characteristics of the virion. | swine vesicular disease is a highly contagious disease of pigs that is caused by an enterovirus of the family picornaviridae. the virus is a relatively recent derivative of the human coxsackievirus b5, with which it has high molecular and antigenic homology. the disease is not severe, and affected animals usually show moderate general weakening and slight weight loss that is recovered in few days, as well as vesicular lesions in the mucosa of the mouth and nose and in the interdigital spaces of ... | 2000 | 11708597 |
| coxsackievirus and adenovirus receptor (car) binds immunoglobulins. | the coxsackievirus and adenovirus receptor protein (car) serves as the cell surface receptor for group b coxsackieviruses and most adenoviruses, but the physiological function and ligand for this protein remain to be described. an affinity column was constructed with the recombinant extracellular domain of the car (recar) to isolate potential ligands by affinity chromatography. immunoglobulins g and m were consistently isolated from human sera passed through the column, suggesting that the car m ... | 2001 | 11724543 |
| no evidence of abnormal regulation of antibody response to coxsackievirus b4 antigen in prediabetic children. | enterovirus infections are a potential environmental trigger of the autoimmune process leading to clinical type 1 diabetes. it has been suggested that the risk of virus-induced beta-cell damage might be connected with a defect in humoral immune responsiveness to enteroviruses. in the present study we assessed whether such a defect in igg responsiveness to coxsackievirus b4 antigen existed in young children who developed diabetes-associated autoantibodies during prospective observation from birth ... | 2001 | 11737058 |
| the group b coxsackieviruses and myocarditis. | the six serotypes of the group b coxsackieviruses (cvb) are common human enteroviruses linked etiologically to inflammatory cardiomyopathies. this has been demonstrated by molecular detection of enteroviral rna in human heart tissue, serologic associations with disease, and virus isolation from cases of fulminant myocarditis. the murine model of cvb-associated myocarditis has demonstrated that cvb can be attenuated through mutations at different genomic sites. human cvb3 isolates demonstrate var ... | 2001 | 11746998 |
| sensitivity of primary cells immortalised by oncogene transfection for the detection and isolation of foot-and-mouth disease and swine vesicular disease viruses. | primary cells derived from calf thyroid (cty), calf kidney (ck) and piglet kidney (pk) were immortalised by oncogene transfection and their susceptibility to infection by foot-and-mouth disease (fmd) virus and swine vesicular disease (svd) virus examined. eighty-five immortalised cell lines (47 cty, 20 ck and 18 pk) proved stable upon repeated cell culture passage and many supported the growth of fmd virus and several of the pk cell lines supported svd virus. however, none of the immortalised li ... | 2002 | 11750139 |
| characterization of neutralization sites on the circulating variant of swine vesicular disease virus (svdv): a new site is shared by svdv and the related coxsackie b5 virus. | using a panel of new monoclonal antibodies (mabs), five neutralizing, conformation-dependent sites have been identified on the antigenic variant of swine vesicular disease virus (svdv) circulating currently. in studies on the antigenic conservation of these sites, the four antigenic/genetic groups of svdv described showed distinguishable patterns, confirming this classification. by sequencing mab-resistant mutants, the five sites have been mapped precisely and localized on a three-dimensional mo ... | 2002 | 11752698 |
| coxsackie b viruses that use human daf as a receptor infect pig cells via pig car and do not use pig daf. | coxsackie b viruses (cvb) are enteroviruses belonging to the family picornaviridae. serotypes 1, 3 and 5 of cvb bind to the human membrane complement regulator decay-accelerating factor (daf) and the coxsackievirus/adenovirus receptor (car), using either or both as receptors. these viruses are known to infect pig cell lines, but the receptor(s) involved has not been identified. we have recently characterized the pig homologue of daf and here explore the interactions of human daf-binding cvb with ... | 2002 | 11752699 |
| molecular phylogeny and proposed classification of the simian picornaviruses. | the simian picornaviruses were isolated from various primate tissues during the development of general tissue culture methods in the 1950s to 1970s or from specimens derived from primates used in biomedical research. twenty simian picornavirus serotypes are recognized, and all are presently classified within the enterovirus genus. to determine the phylogenetic relationships among all of the simian picornaviruses and to evaluate their classification, we have determined complete vp1 sequences for ... | 2002 | 11773400 |
| [sero-monitoring of notifiable diseases in wild boar in the netherlands 1999-2001]. | within the framework of a sero-monitoring system, in operation since 1996. blood samples from wild boar shot during the hunting seasons 1999-2000 and 2000-2001 in the netherlands were screened for the presence of antibodies against classical swine fever virus (csfv), swine vesicular disease virus (svdv), and anjeszky's disease virus (adv). the results indicate that csfv, svdv, and adv are uncommon in the wild boar population in the netherlands. because of the recent foot-and-mouth disease (fmd) ... | 2001 | 11780256 |
| presented antigen from damaged pancreatic beta cells activates autoreactive t cells in virus-mediated autoimmune diabetes. | the induction of autoimmunity by viruses has been attributed to numerous mechanisms. in mice, coxsackievirus b4 (cb4) induces insulin-dependent diabetes mellitus (iddm) resembling the final step of disease progression in humans. the immune response following the viral insult clearly precipitates iddm. however, the molecular pathway between viral infection and the subsequent activation of t cells specific for islet antigen has not been elucidated. these t cells could become activated through expo ... | 2002 | 11781353 |
| epidemiological survey of neonatal non-polio enterovirus infection in the netherlands. | the epidemiological, virological, and clinical data of 119 infants less than 30 days of age with enteroviral infection collected from january 1993 to november 1995 by the diagnostic virology laboratories were analyzed retrospectively. ninety-eight isolates (83%) were obtained in the period of may 1 to december 1 with a peak in the summer months. sixty-five percent (n = 78) of neonates became ill within the first 2 weeks of life. echoviruses and coxsackie virus type b were isolated most frequentl ... | 2002 | 11782934 |
| coxsackie b virus infection in idiopathic dilated cardiomyopathy: clinical and pharmacological implications. | idiopathic dilated cardiomyopathy (idc) is a myocardial disease characterised by ventricular dilatation, impaired contractility, and the symptoms of congestive heart failure. although the causes of idc remain uncertain, much interest has been focused on the enteroviral infection in the myocardium in the pathogenesis of this disease. enteroviral rna has been demonstrated in the myocardium at all stages of idc. recent studies using sequence analysis of enteroviral polymerase chain reaction (pcr) p ... | 2001 | 11784211 |
| [myocardial protection and immunoregulation of minor bupleurum decoction and its decomposed preparations on coxsackie b3m viral myocarditis in mice]. | to study the effect of minor bupleurum decoction (mbd) and its decomposed preparations, decomposition-1 (dc-1) and decomposition-2 (dc-2) in myocardial protection and immunoregulation on coxsackie virus b3m induced myocarditis in mice. | 2000 | 11789192 |
| enterovirus infection can induce immune responses that cross-react with beta-cell autoantigen tyrosine phosphatase ia-2/iar. | insulin-dependent (type 1) diabetes is characterized by progressive destruction of insulin-producing beta cells probably by autoreactive t lymphocytes. viral infections, especially those caused by coxsackieviruses, are postulated to play a role in the pathogenesis of the disease in humans. one mechanism by which viral infections could initiate or accelerate diabetogenic processes is "molecular mimicry," induction of antiviral immune responses cross-reacting with epitopes in the beta-cell autoant ... | 2002 | 11793386 |