Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| torulopsis glabrata vaginitis. | to study the sociodemographic risk factors and clinical features of torulopsis glabrata vaginal infection. | 1995 | 7770272 |
| miller fisher syndrome and anti-gq1b antibodies. | a case is presented of miller fisher syndrome in a 77-year-old woman. the diagnosis was confirmed by the presence of serum igg antibody to ganglioside gq1b. miller fisher syndrome, although uncommon, enters the differential diagnosis of brainstem stroke. | 2006 | 7779653 |
| anti-endometrial lymphocytotoxicity and natural killer cell activity in baboons (papio anubis and papio cynocephalus) with endometriosis. | this study was performed to test the hypothesis that anti-endometrial, lymphocyte-mediated cytotoxicity and natural killer (nk) activity are reduced in baboons with endometriosis when compared to animals with a normal pelvis. lymphocyte-mediated cytotoxicity was determined in 28 baboons (15 with endometriosis, 13 with normal pelvis) and nk cell activity was evaluated in 42 baboons (31 with endometriosis, 11 with normal pelvis). anti-endometrial lymphocyte-mediated cytotoxicity was determined by ... | 1995 | 7782431 |
| [sporulation of the entomopathogenic fungi hirsutella thompsonii fisher and h. nodulosa petch in mixed culture]. | a large-scale method for producing fungal pathogens for mites, hirsutella thompsonii and h. nodulosa in two phase culture (liquid and solid), was developed to induce conidiogenesis. the vegetative growth that was obtained in the liquid media of soy meal with shaking, from an inoculum 0.5 g wet weight equivalent to 0.1 g of dry weight, was inoculated on eight solid supports. generally for most of the strains, the three supports yielding greater conidiogenesis were rice, barley and bran, excluding ... | 2006 | 7784733 |
| appraisal of a glycopeptide cloaking strategy for a therapeutic oligopeptide: glycopeptide analogs of the renin inhibitor ditekiren. | among the limitations to the practical therapeutic oligopeptide are low oral availability, indifferent aqueous solubility, and an astonishing efficient sequestration and biliary elimination by a multi-capacity liver transporter. given the purposed use of n- and o- linked saccharides as functional appendages of eukaryotic peptides and proteins, a strategy of glycopeptide mimicry was examined for the oligopeptide renin inhibitor, ditekiren. the anticipation was that the saccharide would impart sig ... | 1994 | 7788297 |
| [nationwide survey of the distribution of human parasites in china--infection with parasite species in human population]. | the infection rate of main species of parasites and their character by first nationwide survey of human parasites was made. the overall infection rate of human intestinal parasite and the infection rate of most species of parasites were higher in females than that in males. the infection rate according to the age group, the highest infection rate was found in the group aged 5-14 years. with regard to the relation between parasitic infections and occupations of the infected persons, the highest i ... | 1995 | 7788888 |
| a no-touch technique protocol to diminish cerebrospinal fluid shunt infection. | cerebrospinal fluid (csf) shunts become infected primarily by bacterial organisms indigenous to the patient's skin flora, but bacteria from the operating room environment, hospital, or no obvious source may also infect a shunt. to decrease the incidence of shunt infection, a no-touch technique protocol was developed and utilized in a prospective manner. | 1995 | 7792703 |
| spontaneous intestinal inflammation and nitric oxide metabolism in hla-b27 transgenic rats. | it has been reported that transgenic rats expressing the hla-b27 and the beta 2- microglobulin genes develop spontaneous gastrointestinal (gi) inflammation; however, no systematic or quantitative evaluation of this gi inflammation has been reported. therefore, the objective of this study was to characterize quantitatively the gi injury and inflammation observed in commercially available hla-b27 transgenic rats. | 1995 | 7797013 |
| inter-rater reliability of a paediatric outcome measure in nepal. | the hospital and rehabilitation centre for disabled children (hrdc) in nepal identified the need to evaluate their in-hospital and community programmes. an instrument was developed to provide information regarding the functional level of the children treated by the hrdc as well as to provide information regarding care-givers' attitudes towards disability. inter-rater reliability of the measure was tested in three regions of nepal with 49 children. six hrdc field workers travelled in pairs to the ... | 1995 | 7797319 |
| characterization of the effect of cocaine on catecholamine uptake by pregnant myometrium. | to characterize the effect of cocaine on catecholamine uptake by myometrium from pregnant women. | 1995 | 7800333 |
| guillain-barré syndrome. | guillain-barré syndrome has now become recognized as a clinical syndrome that may be due to several pathological entities, consisting of an acute inflammatory demyelinating polyradiculoneuropathy as well as an acute motor axonal neuropathy. campylobacter jejuni infection is a common preceding event and, together with anti-ganglioside gm1 antibodies, is associated with axonal damage and a poor outcome. the mechanism by which such antibodies damage axons is not clear. the miller fisher syndrome is ... | 1994 | 7804457 |
| daunorubicin and daunorubicinol pharmacokinetics in plasma and tissues in the rat. | recent evidence suggests that 13-hydroxy metabolites of anthracyclines may contribute to cardiotoxicity. this study was designed to determine the pharmacokinetics of daunorubicin and the 13-hydroxy metabolite daunorubicinol in plasma and tissues, including the heart. fisher 344 rats received 5 mg kg-1 daunorubicin i.v. by bolus injection. rats were killed at selected intervals for up to 1 week after daunorubicin administration for determination of concentrations of daunorubicin and daunorubicino ... | 1995 | 7805179 |
| [reduced glutathione and l-cysteine in endotoxic shock in the rat]. | reduced glutathione (gsh) is a well known physiological antioxidant, that would protect against lethal effects of endotoxin. however, the site of the action of gsh can be intracellular (transmembrane passage of constitutive amino acids) or extracellular (membrane thiols). | 1994 | 7808645 |
| presence of non-fibrillar amyloid beta protein in skin biopsies of alzheimer's disease (ad), down's syndrome and non-ad normal persons. | a total of 66 skin biopsies from persons with alzheimer's disease (ad) or down's syndrome (ds) and from persons without ad were used in this study. the age range was from 7 to 89 years. positive immunoreactivity of skin biopsies to monoclonal antibody 4g8, which is reactive to amino acid residue 17-24 of synthetic amyloid beta protein (a beta), and 4g8-fab (the antigen-binding fragment of 4g8 igg, reactive only to amyloid plaque) was observed in the epidermis-dermis junction or the basement memb ... | 1994 | 7810290 |
| physiological and structural responses to chronic experimental renal allograft injury. | chronic rejection necessitates a return to dialysis or retransplantation for a significant number of patients with renal allografts. although alloresponses between donor organ and recipient importantly determine this process, the detailed immunologic processes and organ physiology of chronic rejection are unclear; in consequence its mechanism and therapy are uncertain. a model of chronic rejection in the rat was used to examine several facets of this process. fisher-to-lewis (f-l), allogeneic, a ... | 1994 | 7810697 |
| [evaluation of the dtp vaccination technique in infants]. | to evaluate the techniques of dpt vaccination in the nursing child. | 1994 | 7811901 |
| the significance of apical k+ channels in mudpuppy feeding behavior. | behavioral experiments were conducted to determine the effects of known potassium channel blockers, minnow extract (a natural food substance), and other taste stimuli on feeding behavior in the mudpuppy (necturus maculosus). groups of 10-15 mudpuppies were presented with one or more of the following chemicals dissolved in gelatin cubes: h2o (control), nacl (1.0 m; 0.2 m), crude minnow extract (0.1 g/ml), cacl2 (1.0 m), citric acid (0.1 m; ph 2, 0.01 m; ph 3), quinine hcl (0.1 m), tetraethylammon ... | 1994 | 7812724 |
| modulation of natural killer cell-mediated cytotoxicity by tamoxifen and estradiol. | the nonsteroidal antiestrogenic drug, tamoxifen, inhibits the growth of estrogen receptor-positive tumors by interfering with the growth-stimulatory effect of estradiol. however, there is compelling evidence that tamoxifen treatment also is beneficial for patients with estrogen receptor-negative tumors. the hypothesis that tamoxifen is capable of enhancing the immunologic defense of tumor-bearing hosts was been investigated as a possible method for targeting receptor-negative neoplasms. | 1995 | 7812928 |
| fisher syndrome after campylobacter jejuni enteritis: human leukocyte antigen and the bacterial serotype. | we describe two children who had fisher syndrome subsequent to campylobacter jejuni enteritis. the c. jejuni isolates from both patients, who lived in different areas, belonged to pen 2: lio 4. one patient had the following human leukocyte antigens (hlas): hla-a24, 33; b44, 52; dq1; and dr2, 6 antigens. another had the hla-a24, 33; b44, 54; cw1; dq1, 4; and dr4, 6. an effort should be made to isolate c. jejuni from patients with fisher syndrome and to perform hla typing so that the pathogenesis ... | 1995 | 7815224 |
| [methods for studying the distribution of monogenea in the gills of fishes]. | the infection rate with monogeneans of different sites of fish gills was examined. the comparative analysis of average parts (in %) was made after [see text] fisher where phi is a percentage in radians, n -- the number of fishes dissected, v -- degrees of freedom. it was shown statistically, that part (%) of dactylogyrids on ii paris of the gills is significantly greater than parts from i and iii pairs of the gills. the parts of the parasites were not distinguished on i and iii pairs of the gill ... | 2007 | 7816512 |
| conditioned apomorphine-induced turning in 6-ohda-lesioned rats. | apomorphine-induced turning has been used to evaluate the extent of unilateral nigrostriatal denervation after 6-hydroxydopamine (6-ohda) lesions and subsequent functional striatal reinnervation by catecholaminergic grafts. it has been noted that the pregraft rotational pattern is usually double peaked and that fetal ventral mesencephalic grafts or dopaminergic drugs will alter the second peak but leave the first relatively unchanged. we hypothesized that the first peak may be the result of fact ... | 1994 | 7816866 |
| the role of the hippocampal mineralocorticoid and glucocorticoid receptors in the hypothalamo-pituitary-adrenal axis of the aged fisher rat. | the aging process has been frequently associated with hippocampal neurodegeneration, loss of corticosteroid receptors, and, at the same time, dysfunction of the hypothalamo-pituitary-adrenal (hpa) axis. we were interested in characterizing simultaneously the activity of the hpa axis and status of both corticosteroid receptors (mineralocorticoid or mr and glucocorticoid or gr) in the hippocampus of aged male fisher-344 rats. we compared intact, adrenalectomized (adx), and corticosterone-replaced ... | 1994 | 7820364 |
| [delay of the formation of retroperitoneal fibrosis after lymphadenectomy. an experimental study]. | the goal of our study was to evaluate peritoneal and retroperitoneal healing and therefore to assess the optimal date for surgery after laparoscopic lymphadenectomy. a para-aortic lymphadenectomy was carried out in 5 groups of 5 new zealand female rabbits. the perivascular cicatricial tissue was dissected after specific delay for each group (48 hours, 1 week, 2 weeks, 4 weeks, and 6 weeks). peritoneal reconstruction was observed in 80% of the "48 h" group, and in 100% in the other groups (from 1 ... | 1994 | 7822707 |
| somatosensory evoked blink response: findings in patients with miller fisher syndrome and in normal subjects. | reflex blinking was elicited by the electrical stimulation of peripheral nerves and various parts of the body of seven of 11 patients with miller fisher syndrome. this reflex blinking disappeared during recovery. reflex blinking was elicited in normal subjects only with specific stimulation of the peripheral nerves of their upper extremities. this response may be due to a release phenomenon transmitted via the brainstem reticular formation and may be useful in detecting latent cns involvement in ... | 1995 | 7823078 |
| the role of endocervical curettage at cervical conization for high-grade dysplasia. | to quantify the risk of invasive cancer above the location where the conization specimen was taken in patients with an endocervical curettage (ecc) positive for dysplasia at conization for high-grade cervical intraepithelial neoplasia (cin), and to determine if any pathologic features may influence this risk. | 1995 | 7824230 |
| discrimination between patients with acoustic neuroma and with peripheral vestibular lesion by human posture dynamics. | a group of normal subjects (n = 17) was compared with two groups of patients, either with vestibular neuritis (n = 18) or with acoustic neuroma (n = 35) by means of posturography when stance was perturbed with vibrators attached to the calf muscles. dynamic control of human posture was quantified by means of system identification, and the characteristic parameters of swiftness, stiffness, and damping of a transfer function from vibration to force platform response were used for further compariso ... | 1994 | 7825427 |
| cognitive impairment in human chronic chagas' disease. | we proposed to investigate subclinical cognitive impairment secondary to chronic chagas' disease (ccd). no similar study was previously done. the neuropsychological performance of 45 chronic chagasic patients and 26 matched controls (age, education place and years of residency in endemic area) was compared using the mini mental state exam (mmse), weschler memory scale (wms) and the weschler adult intelligent scale (wais). non-parametric tests and chi2 were used to compare group means and multiva ... | 1994 | 7826247 |
| a standardized-patient assessment of a continuing medical education program to improve physicians' cancer-control clinical skills. | although continuing medical education (cme) has long been used to inform physicians and teach specific skills, its efficacy in many areas is not well established. this randomized controlled trial assessed the effects of differing educational techniques on the cancer-control skills of 57 physicians. | 1995 | 7826445 |
| reduced choline acetyltransferase activity and muscarinic m1 receptor levels in aged fisher 344 rat brains did not parallel their respective mrna levels. | differences in the acetylcholine (ach)-mediated neuronal system of the brain between aged and young rats were studied by measuring choline acetyltransferase (chat) activity, muscarinic m1 receptor (m1-r) and their respective mrna levels. in aged rats, chat activity and the m1-r level were significantly reduced in the cerebral cortex, hippocampus and striatum compared with that in young rats. on the other hand, there was no difference in the chat mrna level in the striatum and the basal forebrain ... | 1994 | 7834359 |
| chlorpromazine versus sleep deprivation in activation of eeg in adult-onset partial epilepsy. | we prospectively compared the activating effect of chlorpromazine (chlp, 50 mg, i.m.) versus sleep deprivation (sd) in 41 patients with a clinical diagnosis of partial epilepsy. patients were selected on the basis of both seizure onset in adulthood and normal interictal awake eeg recordings. twenty out of 41 patients (group a) were not yet treated because of either recent onset of epilepsy or misdiagnosis. the remaining 21 patients (group b) were treated with antiepileptic drugs (aed). a control ... | 1994 | 7836964 |
| comparison of polydioxanone and silicone plastic in the prevention of adhesive otitis media in the mongolian gerbil. | adhesion of the tympanic membrane to the promontory may occur in chronic otitis media or in the postoperative ear. silicone plastic sheets are commonly used to form a physical barrier to adhesion. these sheets are generally well tolerated, but they are subject to occasional extrusion, encapsulation, or foreign body reaction. the ideal barrier to adhesion formation would be a nonreactive, flexible, absorbable substance that would obviate long-term toxicity considerations. in this study polydioxan ... | 1995 | 7838554 |
| esophagocoloplasty in children: surgical technique, with emphasis on the double blood supply to the interposed colon, and results. | the description of certain surgical technical modifications of pediatric esophagocoloplasty and their impact on morbidity and mortality rates are presented. seventy children, aged 12 to 120 months (mean, 52.3 +/- 39.5), were divided in two groups. group 1 (40 patients), which represents a historical group, underwent esophagocoloplasty by the conventional technique. group 2 (30 patients) had the following modifications to the operation: (1) preservation of the double blood supply to the interpose ... | 1994 | 7844715 |
| activities of 3':5' cyclic nucleotide phosphodiesterases in the superior cervical ganglion of rat: characterization, compartmentalization and observations in young and old animals. | we investigated the presence and features of "low km" 3'-5' cyclic nucleotide phosphodiesterase activity in the homogenates and extracts of rat superior cervical ganglion. the deae chromatographic elution profile of a triton x-100 extract showed two peaks of camp phosphodiesterase activity eluted at 280 and 600 mm sodium acetate and two peaks of cgmp phosphodiesterase activity eluted at 300 and at 500 mm sodium acetate. the activity was poorly stimulated by calcium-calmodulin and neither stimula ... | 1994 | 7849578 |
| cardiac allografts in rat recipients with simultaneous use of anti-icam-1 and anti-lfa-1 monoclonal antibodies leads to accelerated graft loss. | cardiac allografts from fisher rats underwent acute rejection in wistar king aptekman/hokkaido (wkah) recipient rats. icam-1 molecule was induced in grafted myocytes and interstitial cells during the rejection. lfa-1 (+) inflammatory cells heavily infiltrated into rejected allografts. monoclonal antibodies to rat icam-1 or lfa-1 were administered intravenously to wkah rats receiving fisher cardiac allografts for 3-7 consecutive days after transplantation. anti-lfa-1 treatment for 7 consecutive d ... | 1994 | 7852048 |
| chronic administration of a cocaine "binge" alters basal extracellular levels in male rats: an in vivo microdialysis study. | the purpose of this study was to determine the effects of chronic "binge" administration of cocaine (hourly x 3 i.p.). male fisher rats were treated for 13 days with cocaine (3 x 10 or 15 mg/kg) or saline (3 x 1 ml/kg). on day 14, microdialysis was performed on the rats and all received cocaine (3 x 10 or 15 mg/kg). dialysate samples were collected from the ventromedial (nucleus accumbens and immediate surrounding striatum) and dorsolateral striata. after 13 days of daily cocaine "binges," estim ... | 1995 | 7853178 |
| the effect of irradiation on lung function and perfusion in patients with lung cancer. | to prospectively study the changes in lung function in patients with lung carcinoma treated with relatively high doses of irradiation. | 1995 | 7860406 |
| ethics of research training for nih t32 surgical investigators. | as part of the revised curriculum of the nih t32 training grant mechanism, 6 hr of formal instruction in ethics of research are now required. we therefore implemented a four-session seminar (6 hr total time) structured around assigned readings, didactic presentations, and group discussions. the objective of this research project was to assess whether this new program provided our trainees with a framework for ethical conduct in research. twelve trainees completed the ethics course; 8 trainees wh ... | 1995 | 7861780 |
| heparin versus normal saline as a peripheral line flush in maintenance of intermittent intravenous lines in obstetric patients. | to compare heparin sodium (100 united states pharmacopeia u/ml) with 0.9% sodium chloride for use in the maintenance of intermittent intravenous (iv) devices during pregnancy. | 1995 | 7862386 |
| clinical trials. fisher clashes with nci--again. | 1995 | 7863336 | |
| [two cases of fisher syndrome with histopathological examination]. | 2015 | 7870267 | |
| differences in morphine reinforcement property in two inbred rat strains: associations with cortical receptors, behavioral activity, analgesia and the cataleptic effects of morphine. | the purpose of the current study was to investigate genetic differences between two inbred strains of rats, fisher-344 (f344/n) and wistar albino glaxo (wag/gsto), in a number of drug-naive and drug-related behaviors, including oral and intravenous morphine self-administration. f344/n and wag/gsto rats differed in drug-naive behaviors such as nociception, rearing and sensitivity to lick suppression tests but did not differ in locomotor activity, ambulation or grooming behavior. f344/n rats were ... | 1993 | 7871017 |
| indicators for measuring the quality of family planning services in nigeria. | this article presents the situation analysis approach as a means of collecting data that can be used to assess the quality of care provided by family planning service-delivery points (sdps), and describes the quality of services offered in nigeria. elements of the quality of services provided at 181 clinical service-delivery points in six states of nigeria are described. the substantive results from the study suggest that although most of the 181 service points sampled are functional, the qualit ... | 2007 | 7871552 |
| biochemical characterization of lauric acid omega-hydroxylation by a cyp4a1/nadph-cytochrome p450 reductase fusion protein. | the binding and hydroxylation of lauric acid by a genetically engineered and expressed fusion protein comprised of an n-truncated form of rat cyp4a1 linked to an n-truncated form of rat nadph cytochrome p450 oxidoreductase (or) (constructed by fisher et al., (1992) proc. natl. acad. sci. usa 89, 10817-10822) has been characterized biochemically and compared to that shown by purified reconstituted rat cyp4a1 and liver microsomes from clofibrate-induced rats. in all systems lauric acid induced a t ... | 1995 | 7872779 |
| genetic and environmental variation in eysenck personality questionnaire scales measured on australian adolescent twins. | the eysenck personality questionnaire was administered to 1400 australian twin pairs aged 11 to 18, and the data were analyzed by a multivariate normal model using the software fisher. for each scale, attempts were made to transform to normality, about a mean modeled separately for each sex as a quadratic function of age. variances and covariances were estimated for each sex-zygosity group as a monotone function of age. evidence for genetic sources of variation were assessed in part by fitting m ... | 1994 | 7872928 |
| endonuclease iii interactions with dna substrates. 2. the dna repair enzyme endonuclease iii binds differently to intact dna and to apyrimidinic/apurinic dna substrates as shown by tryptophan fluorescence quenching. | we have measured the fluorescence of the dna repair enzyme endonuclease iii to discover perturbation to its tryptophans by undamaged dna and ap (apyrimidinic or apurinic) dna and to estimate binding affinity for intact and ap dnas. endonuclease iii has two tryptophans, trp132 in a helix-hairpin-helix region of possible flexibility near the active site for ap lyase activity and trp178 in the domain containing the iron-sulfur center of endonuclease iii; trp132 is the more solvent-accessible trypto ... | 1995 | 7873534 |
| bound-morpheme skills in the oral language of school-age, language-impaired children. | bound-morphine skills of school-age, language-impaired (li) children were explored with three tasks designed to assess multiple dimensions of this component of language. ten english-speaking, school-age li children (mean age: 10:3) and ten children with normal language (mean age: 9:9) served as subjects. a two-way analysis of variance revealed significant group differences. fisher a priori testing documented significant group differences for a measure of english bound-morpheme skill levels, a me ... | 1994 | 7876407 |
| predictors of bronchodilator responsiveness in infants with wheezing associated respiratory tract infection. | the responsiveness to bronchodilator is variable in infants with wheezing associated respiratory illness (wari). factors for prediction of the response will lead to more rational use of the bronchodilator in these infants. we examined the possible predictive factors in 44 children under 2 years of age who had their first episode of wari. all of them were treated with 0.15 mg/kg of nebulized salbutamol. thirty patients (68%) with decreasing clinical score > or = 3 after treatment were considered ... | 1994 | 7876752 |
| endometrial feature and uterine blood flow in abnormal uterine bleeding. | we used the transvaginal ultrasound examination in women with abnormal uterine bleeding prior to conventional d&c. it is a simple, non-invasive technic, convenient and accepted by all patients. the endometrial thickness of less than 6 mm is compatible with atrophic endometrium, but of more than 17.7 mm will be malignancy. a cut-off value for endometrial abnormality of 17 mm yielded a sensitivity of 100 per cent, specificity of 96.9 per cent and a positive predictive value of 85.7 per cent respec ... | 1994 | 7876765 |
| miller fisher-guillain-barré overlap syndrome with enhancing lesions in the spinocerebellar tracts. | the site of lesions in miller fisher syndrome, especially those causing ataxia, has been controversial. a 50 year old man with features of miller fisher syndrome in whom mri showed enhancing lesions in the spinocerebellar tracts at the level of the lower medulla is reported. peripheral involvement of cranial nerves was also indicated by an abnormal blink reflex and by clinical manifestations: complete external ophthalmoplegia, bilateral peripheral facial weakness, convergence disturbance, absenc ... | 1995 | 7876862 |
| association between electrocardiographic abnormalities and intracranial blood in patients following acute subarachnoid hemorrhage. | the etiological factors that influence the development of electrocardiographic (ecg) abnormalities following a subarachnoid hemorrhage are not fully understood. the purpose of this study was to assess if there was an association between ecg abnormalities and the amount of intracranial blood seen on computerized tomographic (ct) scanning following an acute bleed in patients with a cerebral aneurysm. the charts of 70 patients who had had a preoperative ct scan and a preoperative ecg within 96 h of ... | 1995 | 7881235 |
| postsurgical intrahepatic portal thromboembolism: a possible cause of perfusion defects on ct during arterial portography. | our goal was to investigate unexplained nontumorous perfusion defects on ct arterial portography (ctap). | 2016 | 7890842 |
| expression of mdr1/p-glycoprotein and p110 in neuroblastoma. | overexpression of the multidrug resistance gene, mdr1, and its product, p-glycoprotein (pgp), has been associated with cross-resistance to structurally unrelated compounds in cell lines and tumours. recently, a non-pgp-mediated form of drug resistance has been described, due to the overexpression of p110, a transport protein. thirty formalin-fixed, paraffin-embedded neuroblastoma samples from 21 cases were examined for overexpression of mdr1 and pgp using newly established non-radioactive in sit ... | 1995 | 7891222 |
| fisher given new role in cancer project. | 1995 | 7892594 | |
| estimating effective population size or mutation rate using the frequencies of mutations of various classes in a sample of dna sequences. | mutations resulting in segregating sites of a sample of dna sequences can be classified by size and type and the frequencies of mutations of different sizes and types can be inferred from the sample. a framework for estimating the essential parameter theta = 4nu utilizing the frequencies of mutations of various sizes and types is developed in this paper, where n is the effective size of a population and mu is mutation rate per sequence per generation. the framework is a combination of coalescent ... | 1994 | 7896116 |
| a microtransplantation approach for cell suspension grafting in the rat parkinson model: a detailed account of the methodology. | shortcomings of current techniques used for the intracerebral transplantation of ventral mesencephalic dopamine neurons include low graft survival, high variability, considerable implantation trauma and suboptimal graft integration. in order to overcome these limitations, we have adopted a microtransplantation approach which allows precise and reproducible implantation of ventral mesencephalon cell suspensions at single or multiple sites with minimal trauma and improved survival and integration ... | 1994 | 7898661 |
| value of wet mount and cervical cultures at the time of cervical cytology in asymptomatic women. | to correlate papanicolaou smear findings with the wet mount and cervical culture results in asymptomatic patients, and to review the value of doing wet mount and/or cervical cultures in these patients at the time of papanicolaou smear. | 1995 | 7898823 |
| comparative metabolism of the renal carcinogen 1,4-dichlorobenzene in rat: identification and quantitation of novel metabolites. | 1. the metabolism of 1,4-dichlorobenzene has been studied in the male and female fisher 344 rat over 72 h after oral administration of 14c-1,4-dichlorobenzene (900 mg = 96.8 microci/kg). no covalent binding of radioactivity could be detected in samples of liver, kidney, lung and spleen. the major route of excretion was with urine accounting for 41.3% of the dose for male and 37.8% of the dose for female rat within 72 h after dosing. 2. urinary metabolites of 1,4-dichlorobenzene were identified a ... | 1994 | 7900412 |
| direct and indirect estimation of the sex ratio of mutation frequencies in hemophilia a. | carrier detection tests were carried out in 119 families with hemophilia a by using the data obtained with current dna techniques (e.g., rflp analysis and direct identification of mutations), conventional carrier detection tests (e.g., factor viii:c and von willebrand factor antigen), and pedigree information. on the basis of this data, we estimated the sex ratio of mutation frequencies with three completely different methods and compared the results. since the classical indirect method derived ... | 1993 | 7902674 |
| effects of nbm lesions on t-maze performance and thalamic biochemistry. | fisher 344 rats underwent bilateral nucleus basalis magnocellularis (nbm) lesioning followed by testing in a delayed nonmatching-to-sample t-maze task. both lesion and control animals acquired the task although the nbm animals were mildly impaired on acquisition and on trials to criterion. increasing the delay reduced accuracy of performance equally in both groups. the nbm lesion did not alter the level of several thalamic amino acids. these data indicate that nbm lesioning does not produce a si ... | 1993 | 7905188 |
| serum factor in miller-fisher variant of guillain-barré syndrome and neurotransmitter release. | serum igg autoantibodies to gq1b ganglioside are associated with the acute phase of the miller-fisher syndrome (mfs). we investigated the effects of three anti-gq1b-positive mfs sera in the mouse phrenic-nerve/diaphragm preparation. miniature endplate potential frequencies increased eight-fold within 25 min, declined rapidly, and ceased altogether after 3 h, when nerve stimulation no longer evoked a response. one mfs convalescent serum (anti-gq1b negative) and sera from healthy controls and from ... | 1994 | 7905957 |
| association of the ss genotype of the l-myc gene and loss of 18q sequences with a worse clinical prognosis in colorectal cancers. | l-myc is a nuclear oncogene which is sometimes activated late in tumourigenesis. digestion of dna with ecori reveals a simple restriction fragment length polymorphism (rflp) located in the second intron of l-myc, with allele sizes 10 kb (l-allele) and 6.6 kb (s-allele). some studies have suggested that the presence of the s-allele in the constitutional dna of a patient with cancer is associated with a higher risk of metastasis in lung, breast and renal cell carcinomas. the aims of this study wer ... | 1994 | 7907781 |
| parkinsonian serum carries complement-dependent toxicity for rat mesencephalic dopaminergic neurons in culture. | the presence of antibodies recognizing specific epitopes of dopaminergic neurons in serum of patients suffering of parkinson's disease (pd) as well as their capability to induce neuronal damage was investigated utilizing serum-free dissociated mesencephalic-striatal co-cultures. high affinity dopamine (da) and gaba uptakes were assessed as specific, functional markers of dopaminergic and gabaergic cell viability, respectively. heat-inactivated serum samples from 18 and 13 patients suffering from ... | 1994 | 7907931 |
| the release and uptake of excitatory amino acids in rat brain: effect of aging and oxidative stress. | the excitatory amino acids (eaas) l-aspartate and l-glutamate constitute the major neurotransmitters in the mammalian brain. this study established the influence of aging and oxidative stress on the release and uptake of eaas. the high affinity uptake of d-[3h]aspartate in synaptosomal fractions of the neostriatum, hippocampus, and neocortex was not significantly different in fisher 344/norwegian brown hybrid rats aged 3, 12, 24, and 37 months. similarly, the k(+)-evoked efflux of endogenous asp ... | 1994 | 7909140 |
| miller-fisher syndrome with rapid recovery. | 1994 | 7910293 | |
| improved body weight status as a result of nutrition intervention in adult, hiv-positive outpatients. | malnutrition is an important consequence of infection with the human immunodeficiency virus (hiv); involuntary weight loss greater than 10% is one criterion that the centers for disease control and prevention uses for the diagnosis of acquired immunodeficiency syndrome (aids). this study was designed to determine whether nutrition intervention in a group of adult, hiv-positive outpatients affected weight maintenance. | 1994 | 7915283 |
| comparison of the effects of salbutamol and clenbuterol on skeletal muscle mass and carcass composition in senescent rats. | aging decreases skeletal muscle mass and strength, making elderly subjects particularly vulnerable to catabolic effects of age-related diseases. clenbuterol, a muscle anabolic beta 2-adrenergic agonist, has reduced or restored skeletal muscle losses in experimental catabolic states. however, the doses of clenbuterol used to prevent or reverse muscle wasting in most animal models have exceeded the estimated safe dose in man. recently, another beta 2-adrenergic agonist, salbuamol (albuterol), has ... | 1994 | 7916118 |
| the linear accuracy of impressions and stone dies as affected by the thickness of the impression margin. | this study compared the dimensional accuracy of impressions and dies made from a metal model simulating prepared abutments and having gingival sulci of varying widths. measurements of the abutments, impressions, and stone dies were made using a travelling microscope, and the number of defects in each impression was recorded. the impressions and dies made from abutments with narrower sulci showed greater distortions. analysis of variance and the fisher plsd post hoc test indicated significant dif ... | 2004 | 7916890 |
| regulation of hippocampal 5-ht1a receptor gene expression by dexamethasone. | the effect of dexamethasone, a selective gr agonist, on hippocampal, 5-ht1a receptor mrna expression and 5-ht1a binding was examined using in situ hybridization histochemistry and in vitro receptor autoradiography. one week after adrenalectomy, both 5-ht1a receptor mrna expression and 5-ht1a binding were increased throughout the hippocampus. administration of dexamethasone at the time of adrenalectomy significantly attenuated the increases in 5-ht1a mrna expression in all hippocampal subfields ( ... | 1994 | 7916919 |
| comparison of popliteal lymph node responses in various strains of rats. | outbred (namely wistar and sprague-dawley) and inbred (wistar-furth, lewis, fisher 344 and brown-norway) strains of rats were screened for their responses to reference compounds in the popliteal lymph node (pln) assay. streptozotocin and diphenylhydantoin gave positive responses as evidenced by increased weight and cellularity indices in all strains used whereas procainamide, isoniazid and barbital consistently gave negative responses. although these findings overall are in agreement with previo ... | 1994 | 7917501 |
| low normal alpha-1-antitrypsin serum concentrations and mz-phenotype are associated with byssinosis and familial allergy in cotton mill workers. | recent studies have shown a close association between byssinosis and airborne endotoxin concentrations. endotoxin might induce byssinosis through the release of biochemical mediators as the broncheoalveolar surface. alpha-1-antitrypsin (alpha-1-a) which neutralizes enzymes released by granulocytes is known to be important. this study evaluates the possible importance of alpha-1-a concentration and the heterozygosity (pi-s and pi-z alleles), in the prevalence of byssinosis and familial allergy. 2 ... | 1994 | 7920693 |
| inflammatory neuropathies. | although not quite as well protected as in the cns, nerve fibres in peripheral nerves are relatively protected from systemic immune responses and inflammatory reactions by the specialized endoneurial endothelial and perineurial barriers. expression of mhc class ii molecules is restricted to a few macrophage-like cells. compared with peripheral nerve trunks, there are more of these cells and more permeable blood vessels in the dorsal root ganglia and spinal roots. these are sites of predilection ... | 1994 | 7921591 |
| miller fisher syndrome and other acute variants of guillain-barré syndrome. | 1994 | 7921593 | |
| [a statistical mean dyad test (tt-criteria for comparison of mean trends of two samples)]. | the authors claim that widely used statistic tests (student, berence-fisher, wilcoxon-mann-whitney, etc.) may fail to detect differences in average trends. a new statistical tt-test is suggested for such situations when samples are compared belonging to essentially different distributions and one of these distributions is bimodal or u-shaped. this test consists in comparison of the arithmetic means calculated not for the whole sample but separately for values higher and lower than the respective ... | 1994 | 7921822 |
| oxygen free radical activity in experimental colonic carcinoma. | oxygen free radical activity has been implicated in carcinogenesis through dna lysis. this study measured chemiluminescence and superoxide dismutase (sod) inhibition as an index of oxygen free radical activity in azoxymethane-induced colonic carcinoma. after 3 weeks of acclimatization, ten fisher 344 rats were injected with azoxymethane (7 mg kg-1 week-1) over 10 weeks. all animals were killed at 37 weeks and colonic mucosa (5-25 mg wet weight) was sampled from sites of histologically confirmed ... | 1994 | 7922065 |
| physicians in health care management: 10. managing conflict through negotiation. | the recent focus on collaborative relationships in health care means that people and groups must cooperate to accomplish clinical and management tasks. this increasing interdependence may also cause increased organizational conflict. the management of conflicts is critical to the effectiveness of an organization. negotiating strategies, based on fisher and ury's method of "principled negotiation," include establishing superordinate goals, separating the people from the problem, focussing on inte ... | 1994 | 7922944 |
| [the diagnosis of cushing's disease by the nocturnal dexamethasone administration test]. | prospective study performed at the general hospital, national medical center, xxi century, endocrinology ward, mexico-city, to compare the diagnostic sensitivity in cushing's disease of the oral high doses (8 mg) dexametazone suppression test in single doses with nocturnal administration (dxm-n) and the classic doses of two days (dxm-c). fourteen patients with hypercortisolism were studied; on thirteen the hypophyseal origin was surgical confirmed. sensitivity of high doses of oral dexametazone ... | 2015 | 7926413 |
| parental imprinting of rat insulin-like growth factor ii gene promoters is coordinately regulated. | the insulin-like growth factor ii (igf-ii) gene is parentally imprinted in the mouse and human species. by following the inheritance of natural polymorphisms of igf-ii mrna, we demonstrated that the tissue-specific parental imprinting of the igf-ii gene is conserved in the rat. the expression of the paternal igf-ii allele exceeded by more than 3 orders of magnitude that of the maternal allele in livers of 3-day-old wistar x fisher interstrain rat crosses. in contrast, the two alleles were both e ... | 1994 | 7929045 |
| inter- and intra-site heterogeneity in the expression of fetal-like phenotypic characteristics by gingival fibroblasts: potential significance for wound healing. | we have previously reported that fetal and adult skin fibroblasts display distinctive migratory phenotypes on 3-d collagen substrata and that these behavioural characteristics may be quantified by a function defined as the cell density migration index (cdmi). subsequent work indicated that this difference in migratory phenotype was due to the production by fetal fibroblasts of a migration stimulating factor (msf) that is not produced by normal adult skin fibroblasts. we now present data indicati ... | 1994 | 7929639 |
| the effect of 6-months l-deprenyl administration on pineal mao-a and mao-b activity and on the content of melatonin and related indoles in aged female fisher 344n rats. | six months of administration of the selective mao-b inhibitor, selegiline (l-deprenyl 0.25 mg/kg, s.c.) to aged female fisher 344n rats suppressed mao-a as well as mao-b activity and increased serotonin (substrate for melatonin biosynthesis) and n-acetylserotonin (immediate melatonin precursor) levels in pineal glands taken from the animals during the night. daytime values were unchanged by the treatment. the data suggest that stimulation of pineal melatonin biosynthesis might be one of the cons ... | 1994 | 7931233 |
| herpes simplex brainstem encephalitis with a relapsing course. | we report a patient with a relapsing form of acute brainstem encephalitis. pathological examination demonstrated necrotizing encephalitis in the cerebral cortex and, more pronounced, throughout the diencephalon, as well as in the pes pontis. neurons and glial cells in the cerebral cortex and brainstem contained herpesvirus antigens. the clinical interrelationship of brainstem encephalitis, miller fisher syndrome and landry-guillain-barré syndrome is discussed. | 1994 | 7931437 |
| the effect of age on halothane-induced alterations of contractility in isolated rat aorta. | aging is implicated as a factor which increases the susceptibility to volatile anesthetic-induced depression of the cardiovascular system. however, little is known regarding mechanisms responsible for this enhanced depression. current experiments examined the effects of 1.2 and 2.4 vol.% halothane on norepinephrine-induced contractility in endothelium-intact and -denuded aortic preparations isolated from 4-, 14-, and 24-month-old fisher-344 rats. prior to exposure to halothane, endothelium remov ... | 1994 | 7934208 |
| activation of cyclin-dependent kinase 4 (cdk4) by mouse mo15-associated kinase. | the assembly of functional holoenzymes composed of regulatory d-type cyclins and cyclin-dependent kinases (cdks) is rate limiting for progression through the g1 phase of the mammalian somatic cell cycle. complexes between d-type cyclins and their major catalytic subunit, cdk4, are catalytically inactive until cyclin-bound cdk4 undergoes phosphorylation on a single threonyl residue (thr-172). this step is catalyzed by a cdk-activating kinase (cak) functionally analogous to the enzyme which phosph ... | 1994 | 7935441 |
| the effect of indomethacin tocolysis on maternal coagulation status. | to investigate the effect of indomethacin tocolysis on maternal coagulation. | 1994 | 7936519 |
| induction of differentiation in human promyelocytic hl-60 leukemia cells activates p21, waf1/cip1, expression in the absence of p53. | the melanoma differentiation associated gene, mda-6, which is identical to the p53-inducible gene waf1/cip1, encodes an m(r) 21,000 protein (p21) that can directly inhibit cell growth by repressing cyclin dependent kinases. mda-6 was identified using subtraction hybridization by virtue of its enhanced expression in human melanoma cells induced to terminally differentiate by treatment with human fibroblast interferon and the anti-leukemic compound mezerein (jiang and fisher, 1993). in the present ... | 1994 | 7936668 |
| importance of margin status in outcome of breast-conserving surgery for carcinoma. | the importance of margin status in breast-conserving therapy (bct) for breast cancer remains unclear. we reviewed our experience with bct to determine the risk of local recurrence as a function of margin status. | 1994 | 7940156 |
| doppler flow measurement in coronary artery bypass grafts and early postoperative clinical outcome. | the present investigation attempts to correlate flow measurements made intraoperatively in coronary bypass grafts with clinical outcome. a total of 352 consecutive patients undergoing isolated coronary artery surgery underwent hemodynamic assessment of their bypass grafts (328 internal thoracic artery and 582 saphenous vein grafts) at the end of cardiopulmonary bypass (cpb) by using a 8 mhz pulsed doppler ultrasound flowmeter. the total patient population was divided into three groups of distinc ... | 1994 | 7940489 |
| mono-(2-ethylhexyl) phthalate suppresses estradiol production independent of fsh-camp stimulation in rat granulosa cells. | di-(2-ethylhexyl) phthalate (dehp) exposure suppressed preovulatory granulosa cell estradiol production in adult cycling rats. the active metabolite of dehp, mono-(2-ethylhexyl) phthalate (mehp), suppressed follicle-stimulating hormone (fsh)-stimulated camp and progesterone production in cultured rat granulosa cells. to examine how dehp altered granulosa cell estradiol production, the effects of mehp were studied in cultures of rat granulosa cells. granulosa cells were obtained from des-implante ... | 1994 | 7940537 |
| issues in biomedical statistics: analysing 2 x 2 tables of frequencies. | how best to analyse statistically experimental results that are set out as a 2 x 2 table of frequencies has been debated by statisticians for more than 50 years. the main issue is what framework of statistical inference should be adopted. the design of most biomedical experiments that result in 2 x 2 tables of independent observations is compatible with the randomization model of inference and with the fisher exact test. it is rare that the neyman-pearson population model is applicable and that ... | 1994 | 7945088 |
| intercellular adhesion molecule-1 and leukocyte function-associated antigen-1 are involved in protection mediated by cd3+tcr alpha beta- t cells at the early stage after infection with listeria monocytogenes in rats. | to investigate the significance of intercellular adhesion molecule-1 (icam-1) and leukocyte function-associated antigen-1 (lfa-1) in host defense against infection with intracellular parasites, we examined the effects of in vivo pretreatment with mabs to icam-1 (1a29) and lfa-1 alpha (wt-1) on the protection against infection with listeria monocytogenes in fisher f344/n rats. expression of icam-1 and lfa-1 alpha molecules on t cells in spleen, liver and peritoneal cavity of rats was down-regulat ... | 1994 | 7947463 |
| the exact analysis of contingency tables in medical research. | a unified view of exact nonparametric inference, with special emphasis on data in the form of contingency tables, is presented. while the concept of exact tests has been in existence since the early work of ra fisher, the computational complexity involved in actually executing such tests precluded their use until fairly recently. modern algorithmic advances, combined with the easy availability of inexpensive computing power, has renewed interest in exact methods of inference, especially because ... | 1994 | 7952429 |
| discovering dental public health: from fisher to the future. | 1994 | 7953939 | |
| progress from clinical trials on breast cancer. | the current management of carcinoma of the breast is very different than it was a relatively few years ago. the improvements in care have been introduced into practice as a result of clinical trials. from the nonrandomized but controlled clinical trial of radical mastectomy by william s. halsted demonstrating that locoregional control could be dramatically improved, trials have become considerably more sophisticated in both design and analysis. randomized clinical trials of breast conservation t ... | 1994 | 7954272 |
| induction in vitro of 72-kd heat shock protein in a continuous culture of rat thyroid cells, frtl5. | in graves' disease and hashimoto's thyroiditis, the presence of 72-kd heat shock protein (hsp-72) on thyrocytes has been reported. to clarify the significance of this phenomenon, we induced the antigen in thyroid cell culture in vitro. in the frtl5 rat cell line, which had been heated at 42.5 degrees c or treated with sodium arsenite, expression of hsp-72 was examined with immunoperoxidase staining and immunoprecipitation of the metabolically labelled protein using a specific moab. in the cells ... | 1994 | 7955528 |
| [a case of chronic inflammatory demyelinating polyneuropathy with recurrent ophthalmoplegia, persistent conduction block, antibody activity against gangliosides gm1]. | we report a 19-year-old female with chronic inflammatory demyelinating polyneuropathy (cidp) with recurrent ophthalmoplegia. the patient had chronic, recurrent, asymmetrical, predominantly, distal limb weakness, and numbness of extremities with recurrent external ophthalmoplegia. ophthalmoplegia developed in each attack of distal limb weakness, and also rapidly subsided with recovery of limb weakness. motor nerve conduction studies revealed conduction block in more than one nerve and conduction ... | 1994 | 7955728 |
| transmission of schistosoma mansoni in rhino camp, uganda. | non-participant observations totalling 204 hours relevant to the transmission of schistosoma mansoni infection were carried out in rhino camp at the shores of albert nile in north uganda. a cross-sectional study of 636 individuals from rhino camp revealed a prevalence of s. mansoni infection of 77.8%. occupational and domestic purposes were the most important reasons for water contact, whereas recreational purposes ranked lower and mainly concerned children. both sexes were equally active in wat ... | 1994 | 7956863 |
| p53 mutations in human bladder cancer. | mutations in the tumor suppressor gene p53 play an important role in carcinogenesis and tumor progression. to assess the status of p53 from genomic dna from bladder cancer samples a two stage polymerase chain reaction was employed. the technique provided material for subsequent detection of mutations by single strand conformation polymorphism (sscp) analysis followed by dna sequence analysis. sscp analysis of exons 5 to 9 of p53 was performed using fragments from pcr end-labeled with 32p followe ... | 1994 | 7957118 |
| dr. c. miller fisher's description of acute cerebellar hemorrhage. | the clinical picture of acute cerebellar hemorrhage and the necessity for rapid recognition and intervention were described by dr. c. miller fisher over 25 years ago. many of his observations and comments are relevant to current practice. | 2004 | 7963399 |
| age-related changes in tissue content of malondialdehyde-modified proteins. | one of the possible mechanisms of the age-related modifications of proteins is the result of reaction with malondialdehyde (mda), a lipid peroxidation byproduct. to determine the effect of age on the extent of mda derivatization of proteins in plasma and various tissues, male fisher 344 rats at 4, 12 and 26 months of age were studied. protein electrophoresis and immunoblotting was carried out using a specific antiserum against mda-protein complexes. the concentration of mda-proteins in plasma (m ... | 1994 | 7968227 |
| magnetic resonance imaging of rodent tumors using radiofrequency gradient echoes. | this paper evaluates the use of radiofrequency (rf) magnetic field gradient echoes to provide contrast in magnetic resonance (mr) images of model tumors. decay of rf gradient echoes as a function of evolution time was measured and sensitivity of the decay to changes in blood pressure was evaluated. previous investigators have demonstrated that static field (b0) gradient echoes provide mr image contrast which is sensitive to the rate of self-diffusion of tissue water and may also be sensitive to ... | 1994 | 7968288 |
| captopril-enhanced 99tcm-mag3 renal scintigraphy in subjects with suspected renovascular hypertension. | this pilot study was undertaken to generate preliminary data on the accuracy of captopril-enhanced renal scintigraphy with a relatively new radiopharmaceutical, 99tcm-mercaptoacetyltriglycine (99tcm-mag3) for detecting significant renal artery stenosis. truth data was based either on arteriographic or outcome criteria (blood pressure response to therapy). twenty-seven subjects with suspected renovascular hypertension were studied with baseline and captopril-enhanced 99tcm-mag3 renal scintigraphy ... | 1994 | 7970428 |