Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| herpes simplex virus complement fixing antibody and herpes b virus serum neutralizing antibody in sera of wild and laboratory-bred cynomolgus monkeys. | the result of the complement fixation (cf) test for the antibody to herpes simplex virus (hsv) in sera of the cynomolgus monkeys was compared with that of the neutralization test (ns) for the antibody to herpes b virus (hbv) in the same sera. fifty-seven (74%) of 77 wild-originated monkeys were positive for hsv-cf, while 65 (84%) of the 77 animals were positive for hbv-sn. all of the 57 cf positive cases were also positive for hbv-sn. on the other hand, 30 (75%) of 40 laboratory-bred monkeys had ... | 1986 | 3011466 |
| laminar distribution of receptors in monkey (macaca fascicularis) geniculostriate system. | we have examined the laminar distributions of eight types of receptor in the primary visual cortex (area 17) and the lateral geniculate nucleus (lgn) of the macaque monkey. the receptor populations and subpopulations examined included those selective for gamma-aminobutyric acid (gaba) (using [3h]-muscimol as ligand), l-glutamate-related receptors (using [3h]-l-glutamate and [3h]-ampa), muscarinic acetylcholine (using [3h]-quinuclidinyl benzilate--qnb and [3h]-n-methyl scopolamine--nms), cholecys ... | 1986 | 3013949 |
| a combination of four cell types for rapid detection of enteroviruses in clinical specimens. | isolation in cell culture is currently the most sensitive and reliable way to demonstrate enterovirus (ev) in clinical specimens. during july-october 1982 and 1983, we studied the impact of adding two new cell lines, buffalo green monkey kidney (bgm) and human rhabdomyosarcoma (rd), to the more traditional cell combination used for ev isolation, human embryonic lung (hel) and primary cynomolgus monkey kidney (cmk) cells; 2,558 specimens were studied: 632 fecal, 677 respiratory, 537 csf, and 712 ... | 1986 | 3016165 |
| epstein-barr virus-related herpesvirus from a rhesus monkey (macaca mulatta) with malignant lymphoma. | a herpesvirus (rhebv) was isolated from a lymphoblastoid cell line (lcl) that became established from a malignant lymphoma in a rhesus monkey. the predominant cell marker in the lcl was that of b lymphocytes. rhebv-induced viral capsid (vca) and nuclear antigens (na) in the lcl were serologically related to similar antigens known to be induced by human epstein-barr virus (ebv). rhebv was of nonhuman primate origin and was clearly differentiated from ebv in the anti-complement immunofluorescence ... | 1986 | 3017870 |
| alternative cell line for virus isolation. | a human lung carcinoma cell line (a549) was compared with various other cell lines to determine susceptibility to viral growth. in the first phase of the study, a549 cells were compared with human embryonic kidney (hek) and cynomolgus monkey kidney (cmk) cells for isolation of upper-respiratory disease viruses by using 1,248 throat swab specimens from basic-combat trainees. of the 552 virus isolates, 507 were adenoviruses, 41 were polioviruses, and 4 were herpes simplex viruses (hsv). of the iso ... | 1986 | 3018038 |
| total iridectomy does not alter outflow facility responses to cyclic amp in cynomolgus monkeys. | total outflow facility was measured by two-level constant pressure anterior chamber perfusion in surgically untouched and totally iridectomized cynomolgus monkey eyes receiving bolus intracameral infusions of cyclic amp, dibutyryl cyclic amp, or 5'amp. cyclic amp doses of 50 and 100 micrograms (corresponding to initial intracameral concentrations of 1.5- and 3 mm) increased facility by approximately 20 and 40% respectively in both surgically untouched and aniridic eyes. higher doses produced no ... | 1986 | 3023122 |
| metabolism and analysis of cysteinyl leukotrienes in the monkey. | predominant hepatobiliary elimination from blood and subsequent enterohepatic circulation of cysteinyl leukotrienes is demonstrated in the monkey macaca fascicularis. from intravenous [3h]leukotriene c4, about 40% were recovered as metabolites in bile and about 20% in urine within 5 h. [3h]leukotriene e4 was a predominant metabolite of defined structure in blood plasma, bile, and urine. from intraduodenal [3h]leukotriene c4, about 5% were recovered as metabolites in bile and about 8% in urine wi ... | 1986 | 3023324 |
| the causes of false-positives encountered during the screening of old-world primates for antibodies to human and simian retroviruses by elisa. | sera from 526 old-world primates representing 50 different species were screened by elisa for antibodies to human t-lymphotropic viruses i and iii, and simian retrovirus type 1 (srv-1). about one-fourth of the sera were positive by elisa. there was a tendency, however, for the same sera to be positive for all three human and simian retroviruses. only about one in five of the elisa antibody-positive sera were confirmed to be positive by western blotting. false-positive elisa antibody tests were p ... | 1986 | 3025237 |
| activation of cytomegalovirus infection in immunosuppressed cynomolgus monkeys inoculated with varicella-zoster virus. | a systemic activated cytomegalovirus (cmv) infection was fortuitously detected in almost all monkeys which had been immunosuppressed with antithymocyte globulin (atg), cyclophosphamide (cy), and cortisone acetate (cs) before and after experimental inoculation with varicella-zoster virus (vzv). they developed exudative pneumonia, and the lesions in visceral organs and tissues contained cytomegalic cells with intranuclear inclusion bodies, in which viral antigens, specific for cmv, but not inocula ... | 1986 | 3026140 |
| alternative 5' exons either provide or deny an initiator methionine codon to the same alpha-tubulin coding region. | the primary structures of two overlapping novel alpha-tubulin cdna clones isolated from a macaca fascicularis testis cdna library and the corresponding human gene are presented. although the general structure of the human gene conforms to that of previously described mammalian alpha-tubulin genes, there is a surprising difference: the atg initiator codon is conspicuously absent. the macaque testis cdna similarly lacks the initiator methionine, but otherwise encodes a variant alpha-tubulin isotyp ... | 1987 | 3029670 |
| receptors and actions of corticotropin-releasing hormone in the primate pituitary gland. | receptors for crh were identified in the pituitary gland of several primate species, and their binding characteristics were compared to the ability of crh to elicit acth and camp responses in vitro. autoradiographic analysis of the binding of [125i]tyr-ovine crh to frozen pituitary sections revealed crh receptors in the intermediate and anterior lobes of human, marmoset, and cynomolgus monkey pituitaries. in the cynomolgus monkey, a high density of crh receptors was present throughout the anteri ... | 1987 | 3031117 |
| the neurovirulence of flaviviruses in crab-eating monkeys (macaca fascicularis). | the neurovirulent properties of attenuated dengue-2 and yellow fever (yf) vaccines, dengue-2 (den-2) and japanese encephalitis (je) viruses were studied in crab-eating monkeys (macaca fascicularis). number of central nervous system sites (as proportion affected) with neurovirulence (nv) lesions were compared. the results indicate that these monkeys reliably developed nv-lesion when inoculated with either je or yf vaccine viruses (87%). nv-lesions occurred in a minority when inoculated with den-2 ... | 1986 | 3033834 |
| effects of suramin on the function and structure of the adrenal cortex in the cynomolgus monkey. | there have been reports of adrenal failure in patients treated with suramin, an agent that has recently been used as therapy for acquired immune deficiency syndrome. we conducted this study to assess the effect of suramin on adrenal function and structure in a primate, the cynomolgus monkey. five male monkeys were treated with suramin (800 mg/m2, im) once a week, for 5 weeks. five other animals (controls) received saline. the treated animals had progressive elevations of plasma acth (p less than ... | 1987 | 3034953 |
| pituitary response to intravenous hypothalamic releasing peptides in cynomolgus monkeys treated with contraceptive steroids. | the secretory response of the pituitary to an iv bolus dose of hypothalamic releasing peptides (hrp) was evaluated in male and cycling (cyc) or contraceptive-treated female cynomolgus monkeys. parenteral delivery of levonorgestrel and 17 beta-estradiol by intravaginal ring (cvr) was compared with oral administration (oc) of norgestrel and ethinyl estradiol in the diet. lh secretion was suppressed in the cvr group compared to that in other groups, and the response in males was greater than that i ... | 1987 | 3034957 |
| adenosine 3',5'-cyclic-monophosphate and outflow facility in monkey eyes with intact and retrodisplaced ciliary muscle. | bolus intracameral infusion of 100 micrograms camp, corresponding to an initial intracameral concentration of 3 mm, significantly increased total outflow facility in cynomolgus monkey eyes with intact or disinserted-retrodisplaced ciliary muscles by 41% and 37% respectively. lower camp doses had little or no effect in both types of eyes, as did dibutyryl camp doses of 1-100 micrograms (20 microm-2mm). in eyes with intact ciliary muscles, intracameral infusion (1 and 10 micrograms) of the camp an ... | 1987 | 3036555 |
| cold-adaptation of human rotavirus. | a human rotavirus strain was cold-adapted for possible future use as a live vaccine. the original strain was isolated in 1980 in primary cynomolgus monkey kidney cells and has a serotype i and subgroup ii antigenicity. the virus was serially passaged in african green monkey kidney cells; it was cultivated at 37 degrees c at the first stage of passages, and the cultivation temperature was then shifted down stepwise by 3 degrees c per each 10 passages. finally the virus was passaged 10 times at 25 ... | 1987 | 3037821 |
| synthesis and characterization of an antihuman t-lymphocyte saporin immunotoxin (okt1-sap) with in vivo stability into nonhuman primates. | the authors conjugated, by a disulphide bond, the antihuman t-lymphocyte (cd5) monoclonal antibody (moab) okt1 to the saporin-6 (sap) ribosome-inactivating protein of the plant saponaria officinalis. the resulting okt1-sap immunotoxin bound to cd5-expressing target cells and under standard culture conditions specifically suppressed mitogen-induced-t-lymphocyte dna and protein synthesis in a dose-related manner. t-lymphocyte killing was achieved by five-minute exposure of the target cells to okt1 ... | 1988 | 3042047 |
| monkey trabecular meshwork cells in culture: growth, morphologic, and biochemical characteristics. | we established tissue cultures of trabecular meshwork cells from cynomolgus monkey eyes. the cultures were initiated within 4 h of enucleation on falcon primaria flasks. using medium containing 10% fetal bovine serum and 5% calf serum, trabecular meshwork cells could be grown for up to eight passages without additional growth factors. the growth pattern and cell morphology were distinct from those seen in fibroblastic or endothelial cultures derived from neighboring tissues. ultrastructurally, o ... | 1988 | 3042523 |
| preclinical toxicology of zidovudine. an overview. | the toxicologic potential of zidovudine (azidothymidine) has been extensively investigated in several species. in rats and mice, the median lethal dose was greater than 750 mg/kg intravenously and greater than 3,000 mg/kg orally. in subacute intravenous toxicity studies, no significant toxicologic alterations were seen in rats or dogs. in cynomolgus monkeys, which as in humans rapidly and extensively glucuronidate zidovudine, a reversible, dose-related, macrocytic anemia was seen in animals give ... | 1988 | 3044084 |
| the extracellular matrix composition of the monkey optic nerve head. | the presence and distribution of laminin, heparan sulfate proteoglycan and collagen types i, iii and iv were immunohistologically determined in cynomolgus monkey optic nerve heads using the avidin-biotin-peroxidase complex technique. collagen types i and iii were detected within the collagenous plates of the scleral lamina cribrosa, in the septa and pia mater of the postlaminar optic nerve and in blood vessel walls in all regions of the optic nerve head. collagen type iv, laminin and heparan sul ... | 1988 | 3047074 |
| use of ultrasound for early pregnancy detection in the rhesus and cynomolgus macaque (macaca mulatta and macaca fascicularis). | diagnostic ultrasound provides an accurate method for the detection of early pregnancy and embryonic loss in macaque species. a developing gestational sac (gs) may be observed on gestational day (gd) 14-15 with positive identification on gd 16-18. visualization of the yolk sac, embryo, and developing heart on gd 21-25 confirms pregnancy. continuous observations during embryogenesis provide useful information when assessing the teratogenic potential of a variety of agents. | 1988 | 3047393 |
| occurrence of 9-deoxy-delta 9,delta 12-13,14-dihydroprostaglandin d2 in human urine. | we have developed a highly sensitive and specific solid-phase enzyme immunoassay for 9-deoxy-delta 9,delta 12-dihydroprostaglandin d2 (delta 12-pgj2) and studied the occurrence of this novel pgd2 metabolite in human urine. the assay detected delta 12-pgj2 over the range of 2-200 pg, and the antiserum showed 2% cross-reaction with pgj2 and less than 0.2% with other pgs. we used this assay and purified the delta 12-pgj2-like immunoreactive substance from human urine. purification consisted of chro ... | 1988 | 3053696 |
| time dependence of chromosomal aberrations induced in human and monkey lymphocytes by acute and fractionated exposure to 60co. | changes in the numbers of peripheral lymphocytes with chromosome aberrations were observed in cynomolgus monkeys after fractionated or acute 60co irradiation at the same total doses. immediately after irradiation, the yield of dicentrics decreased when the dose was fractionated but remained constant for 20 to 80 days, depending on the dose, when irradiation was acute. lymphopenia was greater than expected when the dose was fractionated. the kinetics of the loss of chromosome aberrations and the ... | 1988 | 3055011 |
| endothelial cell ia increases before inflammatory cell infiltration in eae induced in long-tailed macaques. | 1988 | 3061339 | |
| experimental mumps labyrinthitis in monkeys (macaca irus)--immunohistochemical and ultrastructural studies. | three monkeys (macaca irus) were inoculated with mumps virus into unilateral cochleas and their inner ear were examined by immunofluorescent microscopy and transmission electronmicroscopy. the temporal bones were removed after survival period of 14 days when serological tests disclosed elevation of anti-mumps antibody titers. immunofluorescent microscopy revealed that the viral antigen was positive in the stria vascularis. the ultrastructural study revealed that the pathologic changes in the coc ... | 1988 | 3061375 |
| characterization of prenatal growth and development in the crab-eating macaque (macaca fascicularis) by ultrasound. | diagnostic ultrasound is a valuable tool for the examination of various anatomical structures in vivo. improvements in technology have increased its effectiveness and provided a noninvasive method for the in utero observation of a variety of structural and functional events. ultrasound is utilized in our laboratory to monitor a variety of studies during embryonic and fetal development. basic to these evaluations is the ability to assess normal growth and development. the cynomolgus, or crab-eati ... | 2011 | 3063137 |
| occurrence of spontaneous diabetes mellitus in a cynomolgus monkey (macaca fascicularis) and impaired glucose tolerance in its descendants. | spontaneous diabetes mellitus was diagnosed in a cynomolgus monkey. clinical and pathological features, such as abnormal glucose tolerance, loss of insulin response, or degeneration of pancreatic beta-cells, resemble human noninsulin-dependent diabetes mellitus. two descendants of the monkey have developed impaired glucose tolerance and insulin response. genetic factors seem involved in the appearance of carbohydrate intolerance in this family group of monkeys. | 1988 | 3065509 |
| ultrasonic assessment of pregnancy and fetal development in three species of macaque monkeys. | serial ultrasonic assessments of gestational sac (gs) and fetal biparietal diameter (bpd) were performed in the japanese monkey (macaca fuscata fuscata), rhesus monkey (macaca mulatta), and crab-eating monkey (macaca fascicularis). in the japanese monkey, gs increased linearly for 3-8 weeks, whereas bpd increased in a linear-quadratic manner over 8 weeks to term. ultrasonic assessments of spontaneously aborted fetuses with bpd growth retardation and diagnosis of a pelvic chocolate cyst also were ... | 1988 | 3068367 |
| human recombinant derived il-3 and gm-csf in hematopoiesis of normal cynomolgus monkeys. | recent progress in molecular cloning has provided access to several major human colony-stimulating factors - gm-csf, il-3, g-csf and m-csf. now they are available highly purified from different expression systems (e.g. yeast, e. coli, cho cells). these molecules, acting multifunctionally in the hematopoietic system, are responsible for proliferation and differentiation of bone marrow-derived progenitor cells in vitro. first clinical studies performed with colony-stimulating factors have shown th ... | 1988 | 3071338 |
| neuroanatomical localization of cells containing gonadotropin-releasing hormone messenger ribonucleic acid in the primate brain by in situ hybridization histochemistry. | using in situ hybridization histochemistry, we have mapped the anatomic localization of perikarya containing mrna that codes for gnrh and gnrh-associated protein (gap) in the forebrain of four male macaques, macaca fascicularis. dna oligomers, with sequences complementary to either the gnrh or the gap portion of the mrna sequence, were synthesized and hybridized to paraformaldehyde fixed, coronal sections of the basal forebrain and hypothalamus. gnrh mrna was found in the same population of cell ... | 1987 | 3079194 |
| suppression of plasma gonadotropins and testosterone in adult male monkeys (macaca fascicularis) by a potent inhibitory analog of gonadotropin-releasing hormone. | the reduction of circulating levels of gonadotropins and testosterone is of value for the treatment of steroid-dependent neoplasms and the control of fertility. we tested the ability of single and multiple doses of the gnrh antagonist [n-ac-d-nal(2)1, d-pcl-phe2, d-trp3, d-harg(et2)6, d-ala10]gnrh (gnrh-ant) to suppress levels of these hormones in intact and castrate adult male cynomolgus monkeys. in exp i, single injections of the antagonist at doses of 0 (vehicle), 5, 50, 250, and 500 microgra ... | 1986 | 3079603 |
| effects of ovariectomy on vertebral trabecular bone in the cynomolgus monkey (macaca fascicularis). | seventeen ovariectomized and twenty-one intact female cynomolgus macaques were examined for differences in vertebral trabecular bone volume. the ovariectomized group exhibited significantly less trabecular bone than the intact group (p less than .005), 22 months post-ovariectomy. this finding encourages the use of the cynomolgus monkey as a model for the mechanism of bone loss in ovariectomy or postmenopausal osteoporosis. | 1986 | 3079655 |
| ovulation inhibition by administration of weekly gonadotropin-releasing hormone antagonist. | to test the feasibility of administering the gnrh antagonist [(ac-pclphe1,pclphe2,dtrp3,darg6,dala10) gnrh] intermittently to inhibit ovulation, this agent was given to normal ovulatory cynomolgus monkeys once weekly for 4 weeks. ovulation was blocked in all females (eight of eight) throughout the 32 study weeks and resumed within 14.3 +/- 3.8 (+/- sem) days in six of eight primates. interestingly, mean tonic serum estradiol levels were not significantly reduced during treatment. conversely, alt ... | 1986 | 3081571 |
| diagnostic exercise: hepatic granulomas in a cynomolgus monkey. | 1986 | 3083154 | |
| [reproduction in monkeys of non-a, non-b hepatitis transmitted via the fecal and oral routes]. | the paper presents the results of experimental infection of monkeys with virus-containing specimens from a patient with fecal-oral non-a-non-b hepatitis; the study was aimed at the determination of the possibilities of simulating this infection. of the 8 monkeys infected with the material containing virus particles of fecal-oral non-a-non-b hepatitis 5 monkeys developed the infection manifested in virus excretion in fecal specimens, a rise in the level of serum aminotransferases, and typical his ... | 1986 | 3083590 |
| atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. | to test the hypothesis that atherosclerosis impairs endothelium-dependent vascular relaxation, we examined the effect of the endothelium-dependent vasodilators acetylcholine and thrombin and the endothelium-independent vasodilator nitroglycerin on iliac arteries from normal cynomolgus monkeys and cynomolgus monkeys with diet-induced atherosclerosis. rings of iliac artery were suspended in organ chambers at their optimal length for generating tension. after preconstriction with prostaglandin f2 a ... | 1986 | 3087655 |
| regulation of bilirubin glucuronide synthesis in primate (macaca fascicularis) liver. kinetic analysis of microsomal bilirubin uridine diphosphate glucuronyltransferase. | hepatic bilirubin uridine diphosphate glucuronyl-transferase (udp-glucuronyltransferase) catalyzes the formation of bilirubin monoglucuronides (bmg, c-8 and c-12 isomers) and bilirubin diglucuronide (bdg) from bilirubin and the cosubstrate, udp-glucuronic acid. distinctive patterns of bile pigment excretion occur in different species and in pathologic disorders (e.g., gilbert's syndrome). in normal human and monkey (macaca fascicularis) bile, the proportion of bdg exceeds that of bmg and the c-8 ... | 1986 | 3087808 |
| sulphoxidation of s-carboxymethyl-l-cysteine in the rhesus monkey (macaca mulatta), cynomologus monkey (macaca fascicularis), african green monkey (cercopithecus aethiops) and the marmoset (callithrix jacchus). | the metabolic pathways giving rise to the urinary metabolites of s-carboxymethyl-l-cysteine have been identified for the rhesus, cynomologus, african green and marmoset species of monkey. the formation of a sulphoxide metabolite from the sulphide precursor is a reaction important in these species. the metabolic profile displayed by the marmoset was distinct from the three old world species, with the rhesus and cynomologus being similar to man. | 1986 | 3089678 |
| coronary atheroma in the cynomolgus monkey: predictive value of serum and cutaneous lipoprotein measurement. | hyperlipaemia was induced by a high fat diet in 11 cynomolgus monkeys. morphological study of coronary arteries was carried out in 5 coronary samples from these 11 monkeys. the degree of arterial involvement was compared with the serum and cutaneous lipoprotein levels. these experimental data confirm that cutaneous apoprotein b measurement is the best marker for evaluation of coronary atheroma. | 1986 | 3090774 |
| t-cell responses to human aids virus in macaques immunized with recombinant vaccinia viruses. | there is much interest in developing vaccines against acquired immune deficiency syndrome (aids), which is caused by a retrovirus termed human immunodeficiency virus (hiv). isolates of this virus include human t-lymphotropic virus type iii (htlv-iii), lymphadenopathy-associated virus (lav), and aids-associated retrovirus (arv). several approaches towards the development of an aids vaccine result in the production of antibodies in subprimates. these methods involve the use of: antigens isolated f ... | 1986 | 3093891 |
| successful autotransplantation of isolated islets of langerhans in the cynomolgus monkey. | a recently described method for isolation of islets of langerhans from the human pancreas has been adapted to the cynomolgus monkey pancreas. the mean yield of islets obtained from 13 monkey pancreata was 1319 islets per gram of pancreatic tissue (range 533-1800) and the usual purity of the preparation varied from 5 to 15 per cent islet tissue. twelve cynomolgus monkeys underwent total pancreatectomy, preparation of islets from the excised pancreas and autotransplantation to either the spleen or ... | 1986 | 3094618 |
| ovarian responses in macaques to pulsatile infusion of follicle-stimulating hormone (fsh) and luteinizing hormone: increased sensitivity of the maturing follicle to fsh. | this study investigated the relationship between plasma gonadotropin concentrations and the initiation and maintenance of preovulatory follicular growth in macaques. eight adult cynomolgus monkeys were treated with a gnrh antagonist [acd2nal1-4cldphe2, dtrp3, darg6, dala10]gnrh x hoac to block endogenous gonadotropin secretion. in four animals, a pulsatile infusion of human fsh and human lh (hlh) (one 3-min pulse/h) was initiated, and the amount of hfsh delivered per pulse was increased every 3- ... | 1986 | 3095100 |
| blockade of the spontaneous midcycle gonadotropin surge in monkeys by ru 486: a progesterone antagonist or agonist? | preovulatory ovarian secretion of progesterone (p4), several hours before the onset of the typical midcycle gonadotropin surge, occurs in humans and monkeys. we investigated the potentially obligatory role of preovulatory p4 secretion in stimulating the midcycle lh surge by administering a potent p4 antagonist, ru 486(17 beta-hydroxy-11 beta-[4-dimethylaminophenyl-1]17 alpha-[prop-1-ynyl]estra-4,9-dien-3-one), to sexually mature, normally ovulatory cynomolgus monkeys on days 10-12 of the menstru ... | 1986 | 3097053 |
| postnatal changes of igg and igm levels in squirrel monkeys (saimiri sciureus). | serum igg and igm levels were measured in domestically bred squirrel monkeys (saimiri sciureus) ranging in age from 0 days to 42 months, as well as in adult squirrel monkeys from the wild estimated to be 60 months or older. the results indicated that the transplacental transfer of igg occurs in the squirrel monkey but the transferability is lower in the squirrel monkey than in the cynomolgus monkey. immune response in the squirrel monkey occurs just after birth, as shown by igm production. | 1986 | 3100807 |
| identification of inhibin secreted by cynomolgus monkey sertoli cell cultures. | an inhibin was identified in the media of primary sertoli cell-enriched cultures from the cynomolgus monkey, macaca fascicularis, and some of its biochemical properties were studied. conditioned monkey sertoli cell culture medium (m-sccm), when added to pituitary cells from 6-week-old male rats, inhibited the basal secretion of fsh but not that of lh. this specificity was lost after the addition of gnrh; msccm inhibited not only fsh but also lh release, determined by both ria and mouse interstit ... | 1987 | 3102547 |
| contraceptive steroid treatment affects steroid binding proteins and the percentage of free 17 beta-estradiol and testosterone in the cynomolgus monkey (macaca fascicularis). | the levels of steroid binding globulins were characterized in cynomolgus monkeys that were treated with contraceptive steroid preparations delivered either by intravaginal rings (cvr) or orally (oc) in the diet. levonorgestrel (dng) was the bioactive progestin and the estrogen was either 17 beta-estradiol (e2) in the cvr treatment or ethinyl estradiol (ee) in the oc treatment. both contraceptive treatments lowered sex hormone binding globulin (shbg) levels below those observed in males (p less t ... | 1987 | 3104687 |
| homologues of the human c and a apolipoproteins in the macaca fascicularis (cynomolgus) monkey. | we used antisera to human a and c apolipoproteins to identify homologues of these proteins among the high-density lipoprotein apoproteins of macaca fascicularis (cynomolgus) monkeys, and nh2-terminal analysis was used to verify the homology. the nh2-terminal sequence of the m. fascicularis apoa-i is identical with that of another old world species, erythrocebus patas, and differs from human apoa-i at only 4 of the first 24 residues. m. fascicularis apoa-ii contains a serine for cysteine replacem ... | 1987 | 3105581 |
| thyrotropin releasing hormone: effects in monkeys and dogs subjected to experimental circulatory shock. | we tested the hypothesis that thyrotropin releasing hormone (trh) would improve cardiovascular function and survival in circulatory shock by opposing the adverse effects of endogenous opioids and other pathophysiologic mediators. cynomolgus monkeys and mongrel dogs were anesthetized and catheterized to measure mean arterial pressure (map) and left ventricular contractility (lv dp/dtmax). hemorrhagic shock was induced by bleeding into a reservoir to achieve and maintain map at 45 mm hg for one ho ... | 1987 | 3105962 |
| the primary structure of cynomolgus monkey apolipoprotein a-1 deduced from the cdna sequence: comparison to the human sequence. | we have cloned and analyzed a cdna containing the complete coding sequence for cynomolgus monkey apolipoprotein a-1 (apoa-1). this cdna clone was found to share approx. 97% nucleotide sequence identity with the published human apoa-1 and encodes a protein of the same size as the human protein. paired proline residues are present at positions 3 and 4 in the mature protein as has been reported for other primate species and the propeptide sequence is identical to the human propeptide. the amino aci ... | 1986 | 3106152 |
| a molecular phylogeny of the hominoid primates as indicated by two-dimensional protein electrophoresis. | a molecular phylogeny for the hominoid primates was constructed by using genetic distances from a survey of 383 radiolabeled fibroblast polypeptides resolved by two-dimensional electrophoresis (2de). an internally consistent matrix of nei genetic distances was generated on the basis of variants in electrophoretic position. the derived phylogenetic tree indicated a branching sequence, from oldest to most recent, of cercopithecoids (macaca fascicularis), gibbon-siamang, orangutan, gorilla, and hum ... | 1987 | 3106965 |
| contraceptive steroids and coronary artery atherosclerosis in cynomolgus macaques. | the influence of two types of steroidal contraception on the extent of coronary, aortic, carotid, and iliaco-femoral atherosclerosis was assessed in 57 cynomolgus macaques with moderate diet-induced hyperlipoproteinemia. thirteen animals were treated with an intravaginal ring that released 17 beta-estradiol and levonorgestrel. fifteen females were treated with an oral contraceptive (oc) composed of ethinyl estradiol and norgestrel. fifteen females received placebo vaginal rings, and 14 males wer ... | 1987 | 3109954 |
| nucleotide sequence of the delta-beta-globin intergenic segment in the macaque: structure and evolutionary rates in higher primates. | a 5600-base-pair (bp) fragment including the beta-globin gene and about 4000 bp of its 5' flanking sequence was cloned from the dna of macaca cynomolgus (an old world monkey), and the 5' flanking region was sequenced. comparison with human, chimpanzee, mouse, rabbit, and xenopus orthologous sequences reveals a tandemly repeated sequence called rs4 at the same position (about 500 bp 5' from the transcription start of the adult beta-globin gene) in all six species. we suggest that a tandemly repea ... | 1987 | 3110423 |
| nucleotide sequence of the beta-globin genes in gorilla and macaque: the origin of nucleotide polymorphisms in human. | part of the beta-globin genes of macaca cynomolgus and gorilla gorilla has been cloned and sequenced. ten putatively neutral nucleotide polymorphisms have been described at the beta-globin locus in humans. they are associated in seven combinations, which define seven different haplotypes of the beta-globin gene: four major frameworks--1, 2, 3, and 3--and three minor frameworks, which we term ki1, ka1, and or1. the nucleotide sequences of these frameworks are compared with those of homologous seq ... | 1987 | 3110424 |
| enterically transmitted non-a, non-b hepatitis: serial passage of disease in cynomolgus macaques and tamarins and recovery of disease-associated 27- to 34-nm viruslike particles. | an experimental model of enterically transmitted non-a, non-b hepatitis (et-nanbh) was established in tamarins (saguinus mystax mystax) and cynomolgus macaques (macaca fascicularis). first-passage animals were inoculated with two different stool suspensions obtained from human patients with well-defined et-nanbh that originated from burma and pakistan, where epidemics of et-nanbh occur. both inocula contained 27- ato 34-nm-diameter viruslike particles (vlps) that were specifically aggregated by ... | 1987 | 3114746 |
| passive immunization with anti-oestradiol antibodies during the luteal phase of the menstrual cycle potentiates the perimenstrual rise in serum gonadotrophin concentrations and stimulates follicular growth in the cynomolgus monkey (macaca fascicularis). | three unilaterally ovariectomized cynomolgus monkeys, in which menstrual cycles were driven by pulsatile infusion of synthetic gnrh at a fixed frequency of 1 pulse/h, were provided with a continuous infusion of ovine anti-oestradiol gamma-globulin beginning 13 days after ovulation and continuing for 7 days thereafter. plasma concentrations of both fsh and lh rose at the start of the antibody infusion and remained elevated throughout the 7-day treatment regimen when compared with control (non-imm ... | 1987 | 3116229 |
| fixation and occurrence of dark and light cells in taste buds of fungiform papillae. | the fine structure of taste buds of the fungiform papillae of the old world monkey cynomolgus (macaca fascicularis) was found to vary with the primary fixative solution used. standard primary fixative solutions of glutaraldehyde as well as fixatives containing both formaldehyde and glutaraldehyde gave non-reproducible and usually poor results. osmium tetroxide in distilled water gave reproducible fixation of acceptable quality. further, when fixed in osmium tetroxide in distilled water, taste bu ... | 1987 | 3116660 |
| use of indonesian non-human primate erythrocytes for measles hemagglutination inhibition serology. | the use of erythrocytes (rbc) from presbytis cristata, p. melalophus and macaca fascicularis for measles hemagglutination inhibition serologies is presented. these primates can provide a ready supply of rbc for diagnostic reagent use in areas of the world where the african green monkey or rhesus macaque are not available. individuals of each species are useful but must be screened for hemagglutination ability of their erythrocytes. the animal can then be chosen that has erythrocytes which best a ... | 1987 | 3116677 |
| distribution of polychlorinated biphenyl (pcb) and polychlorinated quaterphenyl (pcq) in the cynomolgus monkey (macaca fascicularis). | 1987 | 3117661 | |
| the metabolic efficiency and long-term fate of intraportal islet grafts in the cynomolgus monkey. | 1987 | 3118524 | |
| effect of chronic low dose aspirin on platelet and vascular eicosanoid metabolism in nonhuman primates (macaca fascicularis). | it has been suggested that inhibition of platelet cyclooxygenase by chronic low dose aspirin may spare vascular prostacyclin production. conventional doses of aspirin (greater than 5 mg/kg) have been shown to inhibit the generation of both thromboxane a2 and prostacyclin. low dose aspirin inhibits prostacyclin production by excised human venous tissue, thus questioning the selectivity of such regimens. however, many clinical and surgical conditions requiring platelet inhibition involve the arter ... | 1987 | 3120680 |
| early healing after carotid endarterectomy: effect of high- and low-dose aspirin on thrombosis and early neointimal hyperplasia in a nonhuman primate model. | platelet aggregation and release phenomena are central to most postulated mechanisms of thrombosis and neointimal hyperplasia after carotid endarterectomy. therefore high-dose aspirin (hda) has been advocated to minimize these sources of endarterectomy failure. we have defined low-dose aspirin (lda) that selectively blocks platelet cyclooxygenase but preserves arterial wall cyclooxygenase in the nonhuman primate, macaca fascicularis. we compared this theoretically optimal aspirin dose with hda a ... | 1988 | 3123717 |
| aetiological agent of enterically transmitted non-a, non-b hepatitis. | virus-like particles (vlps) with a mean diameter of 32 nm were recovered from the stools of three acute phase cases of enterically transmitted non-a, non-b hepatitis (et-nanbh) occurring in the soviet union, north africa and north america. vlps from two of these cases were studied in detail and were shown to react specifically with antibody in acute phase sera obtained from other cases of et-nanbh in asia, the soviet union, north africa and north america. partially purified vlps were found to se ... | 1988 | 3127543 |
| apolipoprotein (apo) a-i production and mrna abundance explain plasma apoa-i and high density lipoprotein differences between two nonhuman primate species with high and low susceptibilities to diet-induced hypercholesterolemia. | earlier studies have shown that african green monkeys develop a more modest hypercholesterolemia, higher high density lipoprotein (hdl) concentrations, and less atherosclerosis than cynomolgus monkeys fed diets with the same cholesterol content. in the present study, cynomolgus monkeys were fed less cholesterol than was fed to african green monkeys to induce equivalent hypercholesterolemia in both species. african green monkeys still had 2-fold higher plasma hdl cholesterol concentrations and 2. ... | 1988 | 3128537 |
| pharmacokinetic disposition of the novel atypical anxiolytic cgs 9896 in the cynomolgus monkey. | the intravenous pharmacokinetic disposition of the novel, atypical anxiolytic cgs 9896 was studied in six cynomolgus monkeys. cgs 9896 was infused at dose levels of approximately 60, 120, and 240 micrograms/h/kg for a duration of 12 h, resulting in steady-state plasma concentrations averaging 38.4, 51.8, and 124 ng/ml, respectively. the average total systemic clearance was 35.3 ml/min/kg which was independent of dose and totally attributable to nonrenal pathways. the hepatic clearance was determ ... | 1988 | 3128808 |
| polymorphism of glycophorins in nonhuman primate erythrocytes. | using immunoblotting techniques and polyclonal antisera to human erythrocyte alpha glycophorin, we show that erythrocytes of several species of nonhuman primates, including representatives of anthropoid apes (19 chimpanzees, 3 gorillas, 6 orangutans, and 3 gibbons) and old world monkeys (3 baboons, 5 rhesus monkeys, and 6 cynomolgus macaques), contain human alpha glycophorin-like molecules. each species displays a unique glycophorin profile; in anthropoid apes the profile is more complex than in ... | 1987 | 3128973 |
| nervus terminalis, olfactory nerve, and optic nerve representation of luteinizing hormone-releasing hormone in primates. | the luteinizing hormone-releasing hormone (lhrh) system was examined immunocytochemically in olfactory bulbs of adult monkeys, including two new world species (squirrel monkey, saimiri sciureus and owl monkey, aotus trivirgatus) and one old world species (cynomolgus macaque, macaca fasciculata), and in the brain and nasal region of a fetal rhesus macaque macaca mulatta. lhrh neurons and fibers were found sparsely distributed in the olfactory bulbs in all adult monkeys. there was more lhrh in the ... | 1987 | 3129973 |
| testosterone modulates the differential release of luteinizing hormone and follicle-stimulating hormone that occurs in response to changing gonadotropin-releasing hormone pulse frequency in the male monkey, macaca fascicularis. | selective elevations of plasma follicle-stimulating hormone (fsh) levels are characteristic of some physiological conditions, such as the early stages of human puberty, and in some disorders of testicular function, such as idiopathic oligospermia. we tested the hypotheses that a slow gonadotropin-releasing hormone (gnrh) pulse frequency favors a selective elevation of plasma fsh and that this is influenced by the circulating steroidal milieu. we administered exogenous gnrh at frequencies of once ... | 1988 | 3130109 |
| the presence of carbonic anhydrase in orbital glands. an enzyme-histochemical study in cynomolgus monkeys and rabbits. | the distribution of carbonic anhydrase (ca) was studied in the lacrimal gland of the cynomolgus monkey as well as in the lacrimal, infra-orbital and harderian glands of the rabbit. in the lacrimal gland of the cynomolgus monkey, a number of acini with positive staining were found; however, another group of acini did not stain. in the positively stained acinar cells, large amounts of reaction product were located in the cytoplasm, but only weak staining was observed in the membranes. in the endot ... | 1988 | 3130343 |
| characterization of colonic cellular glycoconjugates in colitis and cancer-prone tamarins versus colitis and cancer-resistant primates. | differences in colonic secretory glycoconjugates (ie, mucin) between normal and ulcerative colitis-prone patients have been noted. similar differences may occur in a corresponding primate model, the cotton-top tamarin (ctt), saguinus oedipus, a new world monkey which suffers from spontaneous chronic colitis and colon cancer. lectin reagents were used to characterize and compare colonic cell surface, cytoplasmic, and secretory glycoconjugates of 9 clinically healthy cotton-top tamarins, 7 colitis ... | 1988 | 3132857 |
| [histochemical studies on the presence of carbonic anhydrase in the lacrimal glands of cynomolgus monkeys and in the orbital glands of rabbits]. | 1988 | 3134280 | |
| follicle-stimulating hormone stimulates spermatogenesis in the adult monkey. | a 2-fold increase in the numbers of germinal cells was observed in the seminiferous epithelium of cynomolgus monkeys treated with 15 iu fsh twice a day during 28 days. no effect was seen after 7 days of treatment. after 16 days only the numbers of apale (ap) spermatogonia had increased to 200% of the control level while the numbers of b spermatogonia, spermatocytes, and spermatids had increased less (160%, 129%, and 100% of the control level, respectively). in the rhesus monkey after the same do ... | 1988 | 3136008 |
| induction of unscheduled dna synthesis in primary cultures of rat, mouse, hamster, monkey, and human hepatocytes. | variation in hepatic metabolism between species may be an important factor in the differences observed in chemical carcinogenesis. we examined 6 chemicals representative of 4 chemical classes in the in vitro hepatocyte dna repair assay using cells isolated from the fischer-344 rat, b6c3f1 mouse, syrian golden hamster, cynomolgus monkey and from human liver. hepatocytes were isolated by in situ or biopsy liver perfusion and incubated with [3h]-thymidine and the test chemical. unscheduled dna synt ... | 1988 | 3137465 |
| experimental hantavirus infection in nonhuman primates. | mild, transient proteinuria and azotemia were produced in three cynomolgus monkeys (macaca fascicularis) and a chimpanzee (pan troglodytes) following intravenous inoculation with prospect hill virus, a hantavirus isolated from meadow voles in the united states. this is the first demonstration of an acute nephropathy in nonhuman primates with the viruses causing hemorrhagic fever with renal syndrome. | 1988 | 3137914 |
| donor deep hypothermia or donor pretreatment with prostaglandin e1 and single pulmonary artery flush for heart-lung graft preservation: an experimental primate study. | using cardiopulmonary bypass to cool the graft and flushing the lungs with cold crystalloid solution are the most popular methods for clinical cardiopulmonary preservation. heart-lung transplantation was carried out in 11 cynomolgus monkeys. donor cardiac preservation was achieved with cold crystalloid cardioplegic solution (10 ml per kilogram of body weight) in all animals. lung preservation was achieved with a rollerhead pump and by cooling (12 degrees c) the donor in one group of 4 animals (d ... | 1988 | 3142374 |
| interaction of uridine 5'-diphosphoglucuronic acid with microsomal udp-glucuronosyltransferase in primate liver: the facilitating role of uridine 5'-diphospho-n-acetylglucosamine. | cytosolic uridine 5'-diphosphoglucuronic acid is the essential cosubstrate for all hepatic microsomal udp-glucuronosyltransferase-mediated reactions. uridine 5'-diphospho-n-acetylglucosamine (udp-glcnac) has been implicated as an activator of udp-glucuronosyltransferases in vivo, acting either as an allosteric effector or by enhancing access of uridine 5'-diphosphoglucuronic acid to the enzyme. to delineate the interaction of uridine 5'-diphosphoglucuronic acid with microsomal udp-glucuronosyltr ... | 1988 | 3142525 |
| regulation of plasma sex-steroid-binding protein in adult cynomolgus monkeys (macaca fascicularis) during different reproductive states. | levels of the sex-steroid binding protein (msbp) have been characterized in cynomolgus monkeys, during different stages of reproduction and under hormonal treatments, by an immunoassay allowing a specific and accurate measurement of the protein itself. using an antiserum specific for native human sbp, we have determined the msbp level by electroimmunodiffusion. this method correlates closely with the binding capacity measured by a steady-state polyacrylamide electrophoresis. the levels are lower ... | 1988 | 3145033 |
| [retinal dopaminergic deficiencies and pattern vision in primates: effect of intravitreal administration of 6-oh-dopamine in macaca fascicularis]. | 1988 | 3146236 | |
| a gonadotropin-releasing hormone agonist and an activator of protein kinase c improve in vitro oocyte maturation in macaca fascicularis. | cynomolgus monkey oocytes were recovered from follicles greater than 1,000 microns in diameter at day 8 in gonadotropin-stimulated cycles and cultured in vitro for 2 days. germinal vesicle breakdown (gvbd) occurred in 30.3% of control oocytes (n = 76) compared with 54.0% and 55.0% of oocytes cultured in presence of a gonadotropin-releasing hormone agonist (gnrha), buserelin (n = 50), or a protein kinase c activator, 1-oleoyl-2-acetyl-racglycerol (oag, n = 40), respective (p less than .01). as si ... | 1988 | 3147939 |
| identification of the primary translation product of the sex steroid-binding protein from monkey liver mrna in a cell-free system. | the synthesis of monkey (macaca fascicularis) sex steroid-binding protein (msbp) in a wheat germ cell-free system in response to liver rna was demonstrated by use of a specific antiserum raised against purified native human sbp. antibodies precipitate a single translation product behaving as a 42 kda protein in sodium dodecyl sulfate polyacrylamide gel electrophoresis (sds-page). western blots of monkey sera subjected to sds-page and immunorevelation show that the native msbp migrates as 2 molec ... | 1988 | 3148331 |
| novel hemoglobin components and their amino acid sequences from the crab-eating macaque (macaca fascicularis). | we found two types of hemoglobin, t and r, from the crab-eating macaque and compared those to a and q previously reported. the 22 animals studied showed six different phenotypes, a, r, qa, qt, qat, and qar. analysis of the complete amino acid sequences for the alpha chains of hemoglobins q, a, t, and r revealed that amino acids at four positions, 8, 55, 71, and 78 from the n-terminal, are variable. in the alpha a chain, thr, val, gly, and gln occupy these positions, and in the alpha q chain the ... | 1988 | 3148734 |
| responses of single neurons in the parietoinsular vestibular cortex of primates. | 1. neurons activated by stimulation of the horizontal and/or vertical vestibular semicircular canals were recorded in the parietoinsular vestibular cortex in four awake java monkeys (macaca fascicularis) and three squirrel monkeys (saimiri sciureus). steady tilt in darkness or during illumination of a vertically striped cylinder or of the normal laboratory surroundings did not lead to a significant change in pivc neuron activity. thus vestibular input to this cortical region seems to be restrict ... | 1988 | 3149165 |
| successful autotransplantation of isolated islets of langerhans in the cynomolgus monkey. | 1987 | 3152650 | |
| the anatomy and histology of the anophthalmic socket--is the myofibroblast present? | for some anophthalmic patients, the contracted socket is a severe problem that precludes the wearing of a prosthesis. a normal and cosmetically acceptable appearance is dependent on the ability of a socket to retain a prosthesis. the disfigurement and distress caused by the contracted socket and its inability to accommodate a prosthesis may have a profound detrimental effect on the patient's career, self-esteem, and psychosocial interactions. the tissue dynamics at work in the anophthalmic socke ... | 1987 | 3154599 |
| the major histocompatibility complex of the cynomolgus monkey. ii. polymorphism at three serologically defined loci and correlation of haplotypes with stimulation in mlc and skin graft survival. | the major histocompatibility complex (mhc) of the cynomolgus monkey has been further characterized by testing in population and family studies 50 new alloantisera along with previously characterized sera. this resulted in the redefinition of three of the original 21 cyla specificities and the identification of 14 additional specificities. genetic evidence for the existence of a third class i locus, designated cyla-c, is presented together with evidence for the linkage of a locus-controlling allo ... | 1985 | 3156824 |
| morphological studies on periodontal disease in the cynomolgus monkey. i. light microscopic observations on gingivitis. | 1985 | 3159872 | |
| morphological studies on periodontal disease in the cynomolgus monkey. ii. light microscopic observations on ligature-induced periodontitis. | 1985 | 3159873 | |
| regional obesity and coronary artery atherosclerosis in females: a non-human primate model. | the relationships between regional obesity, atherosclerosis and atherosclerosis risk factors were studied in female cynomolgus monkeys (macaca fascicularis). in a retrospective necropsy study it was found that females with relatively high central: peripheral fat deposition had three times more extensive coronary artery atherosclerosis. in a second experiment it was found that females with high central fat ratios and females with high levels of whole body obesity were relatively hyperglycemic. in ... | 1988 | 3164976 |
| new attachment through periodontal treatment and orthodontic intrusion. | the present study was performed to investigate the tissue reaction related to orthodontic intrusion of teeth with a reduced periodontium and further to evaluate the influence of oral hygiene on this reaction. in each of five macaca fascicularis monkeys, periodontal tissue breakdown was induced around the premolars and the upper incisors by placing orthodontic elastic ligatures around the teeth. the breakdown procedure was continued until a minimum of four pockets could be measured on probing. fo ... | 1988 | 3165238 |
| periodontal ligament cell kinetics following experimental regenerative procedures. | the present study analyzed the cell kinetics in periodontal ligament (pdl) apical to curetted root surfaces following an experimental regeneration procedure. 3 mm of the buccal and interproximal bone was removed around the premolars and molars in 4 macaca fascicularis monkeys. the exposed root surfaces were planed thoroughly. before replacing the flaps, pieces of millipore filter were attached to the crowns of 1 premolar and 1 molar in each quadrant to cover the exposed roots. the adjacent teeth ... | 1988 | 3165397 |
| multiple dosing of prostaglandin f2 alpha or epinephrine on cynomolgus monkey eyes. iii. histopathology. | prostaglandins (pgs), or their derivatives, are potent ocular hypotensive agents which may prove useful in glaucoma therapy. pgf2 alpha (250 micrograms in 50 microliter saline) or epinephrine 2% solution (50 microliter) was topically applied twice daily for 2 weeks to one eye of six cynomolgus monkeys for each agent. contralateral control eyes received their respective vehicles. by light microscopy, there was no evidence of inflammation, corneal changes, retinal pathology (including cystoid macu ... | 1988 | 3166452 |
| use of the 32p-postlabeling method to detect dna adducts of 2-amino-3-methylimidazolo[4,5-f]quinoline (iq) in monkeys fed iq: identification of the n-(deoxyguanosin-8-yl)-iq adduct. | eight dna adducts of 2-amino-3-methylimidazolo[4,5-f]-quinoline (iq) were found by the standard 32p-postlabeling method in livers from male cynomolgus monkeys fed iq (5 days/week, 3 weeks, 20 mg/kg, nasal-gastric intubation). the iq-dna adduct fingerprints observed in monkeys were identical to those observed in rats that received iq (0.03%) in the diet for 2 weeks. the c8-guanine-iq adduct was identified by comigration with the synthetic 3',5'-bisphosphate derivative of n(-deoxyguanosin-8-yl)-iq ... | 1988 | 3168152 |
| the role of anabolic steroids on baseline and stress heart rate in cynomolgus monkeys. | this investigation examined the role of anabolic steroids on baseline heart rate (hr) and hr responses to the threat of capture in macaca fascicularis. ten cynomolgus monkeys were randomly assigned either to a steroid or to a sham control group. steroid-treated animals were given testosterone injections biweekly for 10 weeks, whereas sham controls received injections of sesame oil on an identical schedule. pretreatment and posttreatment hrs were evaluated to establish both baseline and acute-str ... | 1988 | 3168976 |
| disconnection of the amygdala from visual association cortex impairs visual reward-association learning in monkeys. | cynomolgus monkeys (macaca fascicularis) were trained in a task that assessed their ability to associate visual stimuli with food reward. acquisition of stimulus-reward associations was measured under 2 conditions, a 2-stimuli acquisition condition and a 1-stimulus acquisition condition. on each trial in the 2-stimuli condition, the positive (correct) and negative (incorrect) stimuli were presented side by side and the animal chose one by touching it; if the choice was correct, a food reward was ... | 1988 | 3171671 |
| rearing cynomolgus monkeys (macaca fascicularis) on surrogate mothers with bottle feeding. | fifty-two cynomolgus monkeys were reared in peer groups on surrogate mothers and fed by bottle during the first months of life. a description of the technique of bottle feeding and the structure of surrogate mothers is presented. results are shown in a growth curve. inter-individual differences in body weight were very large. the mean weight was higher in males than in females, but no significant sex differences in growth occurred. the weight of mother-reared infants stayed within the standard d ... | 1988 | 3172702 |
| experimental ocular onchocerciasis in cynomolgus monkeys. iii. roles of igg and ige antibody and autoantibody and cell-mediated immunity in the chorioretinitis elicited by intravitreal onchocerca lienalis microfilariae. | intravitreal injection of small numbers (10-500) of microfilariae (mf) of onchocerca lienalis in eyes of cynomolgus monkeys induces posterior segment lesions which resemble those occurring in human onchocerciasis in some respects. in order to determine the potential roles of antibody and cell-mediated immune responses in the formation of these lesions, anti-onchocerca and anti-retinal igg and ige antibody and peripheral lymphocyte blastogenic responses were followed in eight monkeys, for one wee ... | 1988 | 3175465 |
| localization of vasopressin mrna-containing neurones in the hypothalamus of the monkey. | neuronal perikarya containing vasopressin mrna were detected in cryostat sections of cynomolgus monkey brains by using an in situ hybridization technique. the neurones were observed in hypothalamic regions (supraoptic nucleus, paraventricular nucleus, suprachiasmatic nucleus and accessory supraoptic nucleus). these findings are in agreement with previous reports using immunohistochemical methods. | 1988 | 3179747 |
| a comparison of in vivo and in vitro rates of aging of soman-inhibited erythrocyte acetylcholinesterase in different animal species. | this study was conducted to assess differences in the rate of aging of soman-inhibited erythrocyte (rbc) acetylcholinesterase (ache) from different species and to determine whether the rate of aging in vitro approximates that in vivo following a single exposure to soman. the logarithm of the percentage rbc ache reactivated by 2-pam after soman exposure was plotted as a function of time. linear regression analysis was used to determine the half-time (t1/2) for aging. in the in vivo experiments, t ... | 1988 | 3181042 |
| sem studies of the functional morphology of the ciliary process vasculature in the cynomolgus monkey: reactions after application of epinephrine. | in the ciliary processes of the cynomolgus monkey three vascular territories with discrete arterioles and venules were found by means of scanning electron micrographs of vascular resin casts. the first vascular territory, which is located at the anterior end of the major processes, is drained posteriorly by long isolated venules, which pass the ciliary body without greater connections to the venules of the major ciliary processes, whereas the second and third territories comprise the vasculature ... | 1988 | 3181337 |
| experimental ocular onchocerciasis in cynomolgus monkeys. ii. chorioretinitis elicited by intravitreal onchocerca lienalis microfilariae. | chorioretinitis due to onchocerciasis is a major cause of blindness, and the pathogenesis is poorly understood. we have developed an experimental model for onchocercal chorioretinitis using cynomolgus monkeys (macaca fascicularis). two normal monkeys and two monkeys which had received prior sensitization with subcutaneous injections of live onchocerca lienalis microfilariae were given intravitreal injections of either 0, 10, 50 or 500 live microfilariae. posterior segment changes included disc e ... | 1988 | 3182199 |
| volume flow across the isolated retinal pigment epithelium of cynomolgus monkey eyes. | the retinal pigment epithelium (rpe)-choroid was isolated from cynomolgus monkey eyes with experimental retinal detachments and the volume flow was determined in vitro using ussing-type chambers. with zero pressure difference across the membrane, retina-to-choroid volume flow was 5.0 microliter/hr/cm2 in eyes with subacute retinal detachments (1-2 weeks). in eyes with chronic retinal detachment (8-20 months), the flow was 7.3 microliter/hr/cm2. volume flow was not affected by the elimination of ... | 1988 | 3182200 |