Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| first reported case of a candida glabrata perihepatic abscess as a complication of percutaneous endoscopic gastrostomy tube placement. | 2007 | 17426479 | |
| synthesis and antimicrobial activity of 3-(4'-hydroxy-3'-methylphenyl)-5-[(substuted) phenyl]-4,5-dihydro-1h-1-pyrazolyl-4-pyridylmethanone derivatives. | a series of 3-(4'-hydroxy-3'-methylphenyl)-5-[(substituted) phenyl]-4,5-dihydro-1h-1-pyrazolyl-4-pyridylmethanone derivatives were synthesized by the reaction between isoniazid (inh) and various chalcones and were tested for their antimicrobial activity in vitro against staphylococcus aureus 209p, escherichia coli ess 2231, aspergillus fumigatus, candida albicans, candida albicans atcc 10231, candida krusei go3 and candida glabrata ho5. among the synthesized compounds, all the compounds possess ... | 2006 | 17438865 |
| in vitro antifungal activity of extract and plumbagin from the stem bark of diospyros crassiflora hiern (ebenaceae). | in this study the methanol/dichloromethane (1:1) extract and plumbagin isolated from extract of stem barks of diospyros crassiflora were tested for their antifungal activity against 12 strains of yeast pathogens and filamentous fungi: candida albicans, candida glabrata, candida krusei, candida tropicalis, cryptococcus neoformans, aspergillus niger, aspergillus flavus, alternaria sp., cladosporium sp., geotrichum candidum, fusarium sp. and penicillium sp. the growth of all fungi strains tested wa ... | 2007 | 17444575 |
| enhancement of the in vitro activity of amphotericin b against the biofilms of non-albicans candida spp. by rifampicin and doxycycline. | the in vitro activity of amphotericin b (amb) alone and in combination with rifampicin (rif) and doxycycline (dox) was tested against the biofilms of 30 clinical isolates of non-albicans candida (nac) species namely, candida parapsilosis, candida krusei and candida glabrata. the killing activity of amb at 10 x mic was significantly increased in combination with either antibiotic. with rif, the killing activity increased by 20.6, 23.5 and 14 % against the biofilms of c. parapsilosis, c. krusei an ... | 2007 | 17446287 |
| candida glabrata colonizes but does not often disseminate from the mouse caecum. | candida glabrata is the second or third most frequent cause of candidaemia. the gastrointestinal tract is considered to be a major portal of entry for systemic candidiasis, but relatively few studies have investigated the pathogenesis of c. glabrata. experiments were designed to clarify the ability of c. glabrata to disseminate from the mouse intestinal tract. following oral inoculation, c. glabrata readily colonized the caeca [approx. 10(7) cells (g caecum)(-1)] of antibiotic-treated mice, but ... | 2007 | 17446295 |
| differentiation of candida albicans from non-albicans yeast directly from blood cultures by gram stain morphology. | clusters of pseudohyphae are commonly seen on gram stain of blood cultures from patients with candida albicans fungemia. whether this morphologic feature is useful for differentiating c. albicans from other yeasts has not previously been systematically evaluated. yeast morphology on gram stain of blood cultures from consecutive patients with fungemia detected by the bactec automated blood culture system was prospectively assessed and correlated with the final culture-based yeast identification. ... | 2007 | 17447090 |
| diagnostics of fungal infections in the nordic countries: we still need to improve! | a nordic external quality assessment programme in medical mycology was established in 2005. in order to monitor not 'best practice' but the level of routine diagnostics, specimens were designed to resemble clinical samples and laboratories were asked to handle the samples like routine samples. five simulated clinical samples were distributed to 59 participating nordic laboratories of clinical microbiology. the specimens contained the following microorganisms: 1) candida glabrata and c. albicans ... | 2007 | 17454898 |
| a case of malignant otitis externa caused by candida glabrata in a patient receiving haemodialysis. | a 74-y-old male receiving haemodialysis presented with right-sided otalgia, otorrhoea and diffuse swelling on the right external auditory canal. following an initial successful treatment with prolonged intravenous antibiotics, the patient relapsed with a secondary infection in the same site due to candida glabrata. we report an unusual case of malignant otitis externa caused by the fungus c. glabrata. | 2007 | 17454907 |
| a family of glycosylphosphatidylinositol-linked aspartyl proteases is required for virulence of candida glabrata. | candida glabrata is a yeast pathogen of humans. we have established a tissue culture model to analyze the interaction of c. glabrata with macrophages. transcript profiling of yeast ingested by macrophages reveals global changes in metabolism as well as increased expression of a gene family (yps genes) encoding extracellular glycosylphosphatidylinositol-linked aspartyl proteases. eight of these yps genes are found in a cluster that is unique to c. glabrata. genetic analysis shows that the c. glab ... | 2007 | 17456602 |
| biofilm production by candida species and inadequate antifungal therapy as predictors of mortality for patients with candidemia. | nosocomial candida bloodstream infections rank among infections with highest mortality rates. a retrospective cohort analysis was conducted at catholic university hospital to estimate the risk factors for mortality of patients with candidemia. we reviewed records for patients with a candida bloodstream infection over a 5-year period (january 2000 through december 2004). two hundred ninety-four patients (42.1% male; mean age +/- standard deviation, 65 +/- 12 years) were studied. patients most com ... | 2007 | 17460052 |
| prospective observational study of candidemia in são paulo, brazil: incidence rate, epidemiology, and predictors of mortality. | studies conducted in tertiary care hospitals of different european countries and the united states have shown incidence rates of candidemia ranging from 0.17 to 0.76 and 0.28 to 0.96 per 1,000 admissions, respectively. so far, only 1 study has evaluated the incidence rates of candidemia in tertiary care hospitals in latin american countries. | 2007 | 17464917 |
| beta -1,3 glucan as a test for central venous catheter biofilm infection. | biofilms are microbial communities that are associated with solid surfaces such as intravascular catheters. candida species are a major cause of medical device-associated infections. twenty percent to 70% of all candidemias are associated with this biofilm process. diagnosis and effective treatment of candida device-associated infections requires removal of the involved device. the ability to identify a biofilm device infection before catheter removal may obviate removal of a substantial number ... | 2007 | 17471441 |
| oral epithelium-candida glabrata interactions in vitro. | oropharyngeal candidiasis is a common opportunistic infection and candida glabrata is the second or third most frequently isolated species from oropharyngeal candidiasis lesions, after candida albicans. the aim of this study was to study the cytokine-inducing and cell-damaging potential of c. glabrata in oral epithelial cells and compare this to c. albicans. | 2007 | 17488444 |
| candida inferior vena cava filter infection and septic thrombophlebitis. | candida infection following central venous catheterization (cvc) is a well known complication, most common infection being that caused by candida albicans. less common is infection with candida glabrata. candida septic thrombophlebitis of the central veins is an uncommon complication after cvc. we report the first case of inferior vena cava filter infection with c. glabrata following septic thrombophlebitis of the femoral veins and discuss management of this rare complication. | 2007 | 17495055 |
| new triazole and triazolothiadiazine derivatives as possible antimicrobial agents. | triazole and triazoles fused with six-membered ring systems are found to possess diverse applications in the fields of medicine, agriculture and industry. the new 1,2,4-triazole and 1,2,4-triazolo[3,4-b][1,3,4]thiadiazine derivatives were synthesized as novel antimicrobial agents. the reaction of 1h-indol-3-acetic acid with thiocarbohydrazide gave the 4-amino-3-mercapto-5-[(1h-indol-3-yl)methyl]-4h-1,2,4-triazole. the reaction of triazole with arylaldehydes in ethanol gave the 4-arylideneamino-3 ... | 2008 | 17499887 |
| evaluation of albicans id2 and biggy agar for the isolation and direct identification of vaginal yeast isolates. | in this study, 250 vaginal samples from patients with vulvovaginal candidosis were inoculated onto two chromogenic media, albicans id(2) and biggy agar, as well as onto sabouraud chloramphenicol agar, yielding a total of 63 yeast (25.2 %) on all three media. these strains were identified as candida glabrata in 20 (31.8 %) samples, candida albicans in 15 samples (23.8 %), candida tropicalis in 10 samples (15.9 %), candida krusei in five samples (7.9 %), candida kefyr in five samples (7.9 %), cand ... | 2007 | 17510260 |
| species identification and strain differentiation of clinical candida isolates using the diversilab system of automated repetitive sequence-based pcr. | the diversilab system, which uses repetitive sequence-based pcr (rep-pcr) to genotype micro-organisms, was evaluated as a molecular typing tool for members of the genus candida. initially, 41 clinical candida spp. (7 candida krusei, 10 candida parapsilosis, 7 candida albicans, 10 candida tropicalis and 7 candida glabrata), previously identified at the species level by morphological and biochemical analysis, were analysed with the diversilab system. species identification was confirmed by dna seq ... | 2007 | 17510263 |
| development of a highly efficient gene targeting system induced by transient repression of yku80 expression in candida glabrata. | in the pathogenic yeast candida glabrata, gene targeting to generate knockouts and "knockins" is a potentially powerful method for the analysis of gene function. its importance increased after the c. glabrata genome sequence project, but progress in the field is hampered by inefficient mechanisms for gene targeting. with the use of 40-bp homologous flanking dna, no gene targeting was identified. to address this issue, yku80 was disrupted, leading to an increase in targeting efficiency of 5.1% us ... | 2007 | 17513567 |
| measurement of voriconazole activity against candida albicans, c. glabrata, and c. parapsilosis isolates using time-kill methods validated by high-performance liquid chromatography. | we developed a high-performance liquid chromatography (hplc) assay to validate time-kill and postantifungal-effect (pafe) experiments for voriconazole against candida albicans, candida glabrata, and candida parapsilosis isolates. voriconazole exerted prolonged fungistatic activity but no pafe at concentrations achievable in human sera. hplc confirmed that experiments were conducted at the desired steady-state voriconazole concentrations. | 2007 | 17517840 |
| high- versus low-dose fluconazole therapy for empiric treatment of suspected invasive candidiasis among high-risk patients in the intensive care unit: a cost-effectiveness analysis. | high-dose fluconazole is an alternative for patients with candidemia caused by candida glabrata or other candida species with decreased fluconazole susceptibility. however, empiric high-dose fluconazole is not currently recommended and may result in higher drug costs and toxicity. | 2007 | 17519072 |
| recent advances in antifungal chemotherapy. | for over 50 years, amphotericin b deoxycholate (ambd) has been the 'gold standard' in antifungal chemotherapy, despite its frequent toxicities. however, improved treatment options for invasive fungal infections (ifis) have been developed during the last 15 years. newer antifungal agents, including less toxic lipid preparations of ambd, triazoles and the echinocandins, have been added to our armamentarium against ifis. some of these newer drugs can now replace ambd as primary therapy (e.g. caspof ... | 2007 | 17524625 |
| factors influencing caspofungin plasma concentrations in patients of a surgical intensive care unit. | co-morbidity, medical and surgical interventions often cause alterations to drug plasma concentrations and pharmacokinetic parameters in critically ill patients. in the present study, we investigated parameters influencing plasma caspofungin concentrations in patients of a surgical intensive care unit (sicu). | 2007 | 17525052 |
| caspofungin for the treatment of less common forms of invasive candidiasis. | caspofungin has demonstrated efficacy in invasive candidiasis. however, in a comparative study, most patients (>83%) had candidaemia. therefore, we performed a study in patients with non-fungaemic invasive candidiasis. | 2007 | 17526917 |
| assessment of candida glabrata strain relatedness by pulsed-field gel electrophoresis and multilocus sequence typing. | in this study, 80 candida glabrata isolates from intensive care unit and human immunodeficiency virus (hiv)-infected patients were typed by multilocus sequence typing (mlst), pulsed-field gel electrophoresis (pfge), and mating type class determination. among the 25 patients with multiple isolates, 19 patients (76%) contained multiple isolates exhibiting identical or highly related pfge and mlst genotypes, which may indicate the maintenance or microvariation of one c. glabrata strain in each pati ... | 2007 | 17553975 |
| cure of candida glabrata native tricuspid valve endocarditis by continuous infusion of conventional amphotericin b in a patient with nephrotic syndrome. | 2007 | 17555946 | |
| ce separation of proteins and yeasts dynamically modified by peg pyrenebutanoate with fluorescence detection. | the optimized protocols of the bioanalytes separation, proteins and yeasts, dynamically modified by the nonionogenic tenside peg pyrenebutanoate, were applied in cze and cief with the acidic gradient in ph range 2-5.5, both with fluorescence detection. peg pyrenebutanoate was used as a buffer additive for a dynamic modification of proteins and/or yeast samples. the narrow peaks of modified analytes were detected. the values of the pi's of the labeled proteins were calculated using new fluorescen ... | 2007 | 17557360 |
| prevalence of oral candida species in leprosy patients from cambodia and thailand. | leprosy is a chronic bacterial infection which may lead to significant orofacial morbidity. however, reports on the oral mycotic flora of leprosy patients are rare. the aim of the current study was to explore the oral yeast carriage in two groups of leprosy patients. | 2007 | 17559495 |
| trends in candidemia and antifungal susceptibility in a university hospital in northern ireland 2001-2006. | to describe the species distribution and antifungal susceptibility trends for documented episodes of candidemia at the royal hospitals, belfast, 2001-2006. | 2007 | 17560655 |
| epidemiology and antifungal susceptibilities of candida spp. to six antifungal agents: results from a surveillance study on fungaemia in germany from july 2004 to august 2005. | data on fungal infections occurring in germany are rare to date. the aim of the present study was to survey the epidemiological situation in germany, to provide data on the susceptibility of the fungal isolates to antifungals. | 2007 | 17562683 |
| fungemia at a tertiary care hospital: incidence, therapy, and distribution and antifungal susceptibility of causative species. | the aim of this study was to review fungal bloodstream infections at a large tertiary care hospital to evaluate the incidence of fungemia and the distribution of causative species during the period 2001-2005. another aim was to assess the extent of antifungal resistance. a review of all episodes of fungemia at the university hospitals of leuven (belgium) was conducted between january 2001 and december 2005. for the first yeast isolate collected from each non-mould fungemic episode during a 1-yea ... | 2007 | 17569999 |
| adequacy of empirical antifungal therapy and effect on outcome among patients with invasive candida species infections. | although inadequate antimicrobial therapy has been demonstrated in multiple studies to increase the risk for death in bacterial infections, few data investigating the effect of antifungal therapy on outcome of serious fungal disease are available. we sought to assess the adequacy of empirical therapy and its effect on mortality in invasive candida species infections. | 2007 | 17576697 |
| rapid differentiation between fluconazole-sensitive and -resistant species of candida directly from positive blood-culture bottles by real-time pcr. | in view of both the delay in obtaining identification by conventional methods following blood-culture positivity in patients with candidaemia and the close relationship between species and fluconazole (flc) susceptibility, early speciation of positive blood cultures has the potential to influence therapeutic decisions. the aim was to develop a rapid test to differentiate flc-resistant from flc-sensitive candida species. three taqman-based real-time pcr assays were developed to identify up to six ... | 2007 | 17577063 |
| [virulence of the opportunistic pathogen mushroom candida glabrata]. | candida glabrata is an opportunistic fungal pathogen that has become increasingly frequent in bloodstream and mucosal infections in immunocompromised patients. c. glabrata is phylogenetically more closely related to s. cerevisiae than to c. albicans, and some well identified virulence factors in c. alhicans do not seem to be conserved in c. glabrata. however. other important traits are shared by both organisms, and these may play a role in the adaptation and survival in the host as opportunistic ... | 2006 | 17578074 |
| [cellular response to stress]. | environmental changes induce a cellular response characterized by a modification in the genetic expression and physiology of the cell. this modification allows the cell to survive and adapt to the new environment. current studies on cellular stress response are mainly focused on the identification of the genetic expression patterns (transcriptome, proteome). and their relation with the biochemical (metabolome), structural and functional changes displayed by the cells under stress. in the symposi ... | 2006 | 17578088 |
| changes in karyotype and azole susceptibility of sequential bloodstream isolates from patients with candida glabrata candidemia. | we examined the changes in genotypes and azole susceptibilities among sequential bloodstream isolates of candida glabrata during the course of fungemia and the relationship of these changes to antifungal therapy. forty-one isolates were obtained from 15 patients (9 patients who received antifungal therapy and 6 patients who did not) over periods of up to 36 days. the isolates were analyzed using pulsed-field gel electrophoresis (pfge) and multilocus sequence typing (mlst) and tested for antifung ... | 2007 | 17581937 |
| a phylogenetic analysis of the sugar porters in hemiascomycetous yeasts. | a total of 214 members of the sugar porter (sp) family (tc 2.a.1.1) from eight hemiascomycetous yeasts: saccharomyces cerevisiae, candida glabrata, kluyveromyces lactis, ashbya (eremothecium) gossypii, debaryomyces hansenii, yarrowia lipolytica, candida albicans and pichia stipitis, were identified. the yeast sps were classified in 13 different phylogenetic clusters. specific sugar substrates could be allocated to nine phylogenetic clusters, including two novel tc clusters that are specific to f ... | 2007 | 17587872 |
| the medically important yeasts present in clinical specimens. | in an effort to determine the yeast species present in clinical specimens obtained from patients attending a busy saudi hospital, the present study was undertaken. more than 1614 yeasts were isolated in culture from pathologic specimens of over 1303 patients with diverse clinical conditions. organisms identified in 22 species of eight general included: candida albicans, c. parapsilosis, c. tropicalis, c. krusei, c. lipolytica, c. guilliermondii, c. pseudotropicalis, c. pinotolopesii, c. humicola ... | 1992 | 17589130 |
| breakthrough fungal infections after allogeneic hematopoietic stem cell transplantation in patients on prophylactic voriconazole. | seventy-one allograft recipients receiving voriconazole, in whom complete clinical, microbiologic and pharmacokinetic data were available, were studied to determine the efficacy of voriconazole in preventing fungal infections. the length of voriconazole therapy was 6-956 days (median 133). the total number of patient-days on voriconazole was 13 805 ( approximately 38 years). a total of 10 fungal infections were seen in patients on voriconazole (18% actuarial probability at 1 year): candida glabr ... | 2007 | 17589527 |
| comparison of a randomly amplified polymorphic dna (rapd) analysis and atb id 32c system for identification of clinical isolates of different candida species. | the objective of this work was to compare the usefulness of a randomly amplified polymorphic dna (rapd) assay to that of the atb id32c kit (biomérieux, france) for identification of different species of candida isolated from clinical specimens. the rapd-pcr patterns obtained with ope-18 primer for identification of clinical isolates were consistent, and the different independent assays revealed reproduction of the band patterns. rapd with the ope-18 primer is a very specific and sensitive method ... | 2007 | 17604435 |
| rhodotorula glutinis fungemia in a liver-kidney transplant patient. | a 54-year-old man underwent simultaneous liver-kidney transplantation. during his prolonged hospitalization, he developed catheter-related fungemia with rhodotorula glutinis and azole-resistant candida glabrata. management of the rhodotorula fungemia was complicated by his renal insufficiency, hepatic insufficiency, and the concurrent fungemia with multi-azole resistant c. glabrata. he was treated with combination therapy with voriconazole and micafungin with subsequent clearance of the fungemia ... | 2008 | 17605726 |
| [candida glabrata chorioamnionitis following in vitro fertilization]. | we report one case of severe candida glabrata chorioamnionitis and septicemy occurring in a twin pregnancies achieved by in vitro fertilization techniques which resulted in pregnancy loss after preterm rupture of the membrane at 22 weeks of gestation despite a treatment with amphotericin b. | 2007 | 17616266 |
| the high-osmolarity glycerol response pathway in the human fungal pathogen candida glabrata strain atcc 2001 lacks a signaling branch that operates in baker's yeast. | the high-osmolarity glycerol (hog) mitogen-activated protein (map) kinase pathway mediates adaptation to high-osmolarity stress in the yeast saccharomyces cerevisiae. here we investigate the function of hog in the human opportunistic fungal pathogen candida glabrata. c. glabrata sho1delta (cgsho1delta) deletion strains from the sequenced atcc 2001 strain display severe growth defects under hyperosmotic conditions, a phenotype not observed for yeast sho1delta mutants. however, deletion of cgsho1 ... | 2007 | 17616630 |
| comprehensive review of conventional and non-conventional methods of management of recurrent vulvovaginal candidiasis. | recurrent vulvovaginal candidiasis (vvc) is a condition what causes women a great deal of discomfort, inconvenience, and sometimes has psychological sequelae.(1) this condition is notoriously difficult to manage. conventional management is generally favoured by medical practitioners. some practitioners prefer not to offer other options because of significant possible side-effects and the lack of research supporting alternative treatments. there are many studies and much available information sur ... | 2007 | 17627679 |
| one year prospective survey of candida bloodstream infections in scotland. | a 12 month survey of candidaemia in scotland, uk, in which every scottish hospital laboratory submitted all blood isolates of yeasts for identification, strain typing and susceptibility testing, provided 300 isolates from 242 patients, generating incidence data of 4.8 cases per 100,000 population per year and 5.9 cases per 100,000 acute occupied bed days; 27.9 % of cases occurred in intensive care units. more than half the patients with candidaemia had an underlying disease involving the abdomen ... | 2007 | 17644714 |
| in vitro antimicrobial properties of coconut oil on candida species in ibadan, nigeria. | the emergence of antimicrobial resistance, coupled with the availability of fewer antifungal agents with fungicidal actions, prompted this present study to characterize candida species in our environment and determine the effectiveness of virgin coconut oil as an antifungal agent on these species. in 2004, 52 recent isolates of candida species were obtained from clinical specimens sent to the medical microbiology laboratory, university college hospital, ibadan, nigeria. their susceptibilities to ... | 2007 | 17651080 |
| [minimal inhibitory concentrations of candida species to five antifungals by using the reference dilution micromethod and the e-test.]. | it is accepted that the frequency of candidosis has increased during the last decade, specially in hospitalized patients. the more frequent use of azole antifungals and the recognition of isolates of candida sp resistant to these and other drugs such as 5-fluorocytosine constitute a great need for a reproducible and useful c. albicans in vitro susceptibility testing method for monitoring antifungal therapy in clinical mycological laboratories. the e-test is a novel agar diffussion technique for ... | 1997 | 17655386 |
| attachment and entry of candida famata in monocytes and epithelial cells. | candida albicans is considered the main pathogenic yeast responsible for a multitude of infective disorders. however, other yeasts, such as candida famata, are being recognized as potential emerging pathogens that cause several types of infections in humans and animals. consequently, we have investigated the adhesion and internalization of candida famata into monocytes and epithelial cells. the interaction of the yeast with the cells is very rapid and takes place during the first 15 min of injec ... | 2007 | 17661391 |
| [in vitro activity of amphotericin b, fluconazole and itraconazole against candida glabrata strains isolated from clinical samples]. | in recent years, the incidence of candida albicans infections tends to decrease, at least in some centers other candida species have emerged as opportunistic pathogens. among non-albicans candida species, c. glabrata is one of the most frequently isolated species. in this study, the in vitro activities of amphotericin b, itraconazole and fluconazole were tested against 134 clinical c. glabrata strains. the isolation and identification of the isolates were done by standard mycological methods. mi ... | 2007 | 17682710 |
| production of indole pigments by candida glabrata. | when provided as the sole nitrogen source tryptophan induces the production of several indole alkaloids, e.g., pityriacitrin, malasseziaindole, pityriaanhydride and pityriarubin with proven biological activity in the lipophilic yeast malassezia furfur. so far these pigments seem to have been unique and only produced by highly specialized basidiomycetal yeasts of the genus malassezia. having surprisingly observed a brown pigmented candida glabrata isolate as a contaminant on such a pigment induci ... | 2007 | 17710621 |
| community-onset candidemia at a university hospital, 1995-2005. | although not all candidemias are hospital-acquired, data on clinical epidemiology for the community-onset candidemia are limited. this retrospective study was conducted to describe predisposing factors and outcomes of community-onset candidemias. | 2007 | 17712471 |
| erythematous candidosis in patients with complete dentures and hiv+/aids. | this investigation was designed to evaluate the frequency of erythematous candidosis (ec) and candida species, proteinase and phospholipase exoenzyme production, and to compare clinical features in patients with complete dentures and hiv+/acquired immunodeficiency disease syndrome (aids). fifty-one patients were selected from a total of 285 with ec: denture wearers (n = 30) and hiv+/aids (n = 21). the yeast prevalence and the production of exoenzymes, such as proteinase and phospholipase by cand ... | 2007 | 17714362 |
| dna microarray-based detection and identification of fungal pathogens in clinical samples from neutropenic patients. | the increasing incidence of invasive fungal infections (ifi) in immunocompromised patients emphasizes the need to improve diagnostic tools. we established a dna microarray to detect and identify dna from 14 fungal pathogens (aspergillus fumigatus, aspergillus flavus, aspergillus terreus, candida albicans, candida dubliniensis, candida glabrata, candida lusitaniae, candida tropicalis, fusarium oxysporum, fusarium solani, mucor racemosus, rhizopus microsporus, scedosporium prolificans, and trichos ... | 2007 | 17715373 |
| candida interface keratitis after deep anterior lamellar keratoplasty: clinical, microbiologic, histopathologic, and confocal microscopic reports. | to report the clinical, histopathologic, microbiologic, and confocal microscopic features of candida keratitis after deep anterior lamellar keratoplasty (dalk). | 2007 | 17721287 |
| quiz page. acute renal failure caused by renal allograft infection with c glabrata. | 2007 | 17724848 | |
| assimilation of nad(+) precursors in candida glabrata. | the yeast pathogen candida glabrata is a nicotinamide adenine dinucleotide (nad(+)) auxotroph and its growth depends on the environmental supply of vitamin precursors of nad(+). c. glabrata salvage pathways defined in this article allow nad(+) to be synthesized from three compounds - nicotinic acid (na), nicotinamide (nam) and nicotinamide riboside (nr). na is salvaged through a functional preiss-handler pathway. nam is first converted to na by nicotinamidase and then salvaged by the preiss-hand ... | 2007 | 17725566 |
| changing pattern of candidaemia 2001-2006 and use of antifungal therapy at the university hospital of vienna, austria. | a retrospective survey of candidaemia between 2001 and 2006 was performed at the university hospital of vienna, a 2200-bed centre with large organ transplantation and haematology-oncology units. the incidence rate of candida spp. in blood cultures increased from 0.27 cases/1000 admissions in 2001 to 0.77 cases/1000 admissions in 2006 (p <0.005). the incidence of candidaemia caused by candida albicans and by non-albicans candida spp. both increased during this period; although there was a trend t ... | 2007 | 17725647 |
| the pan-ac assay: a single-reaction real-time pcr test for quantitative detection of a broad range of aspergillus and candida species. | in view of the growing incidence and the high mortality of invasive aspergillosis and candidiasis, adequate diagnostic techniques permitting timely onset of treatment are of paramount importance. more than 90 % of all invasive fungal infections in immunocompromised individuals can be attributed to candida and aspergillus species. to date, standardized techniques permitting rapid, sensitive and, no less importantly, economic screening for the clinically most relevant fungi are lacking. in the pre ... | 2007 | 17761478 |
| candida glabrata and candida albicans; dissimilar tissue tropism and infectivity in a gnotobiotic model of mucosal candidiasis. | germ-free transgenic epsilon 26 (tgepsilon26) mice, deficient in both natural killer (nk)- and t-cells, were inoculated (orally) with each of two candida glabrata (bg2 or bg1003) or candida albicans (caf2-1 or sc5314) strains. candida glabrata- or c. albicans-colonized mice exhibited similar numbers of viable candida in the alimentary tract. neither c. glabrata nor c. albicans caused systemic candidiasis of endogenous (alimentary tract) origin. candida albicans invaded oroesophageal (tongue, pal ... | 2007 | 17854475 |
| multiple-locus variable-number tandem-repeat analysis for rapid typing of candida glabrata. | a multiple-locus variable-number tandem-repeat analysis (mlva) using six microsatellite markers was assessed in 127 candida glabrata isolates. thirty-seven different genotypes, stable both in vitro and in vivo, were observed. the highest discriminatory power (d = 0.902) was reached by using only four markers. mlva seems to be relevant for c. glabrata typing. | 2007 | 17855568 |
| susceptibility patterns of candida species recovered from canadian intensive care units. | the objective of this study was to determine the speciation and susceptibility patterns of candida species recovered from canadian intensive care units (icus) during a 1-day point-prevalence study on fungal colonization/infection in canadian icus. | 2007 | 17869976 |
| [in vitro antifungal activity of voriconazole: new data after the first years of clinical experience]. | voriconazole has been developed to meet the increasing need for new and useful antifungal agents for the treatment of invasive mycoses. this review describes the spectrum of voriconazole antifungal activity based on data from in vitro studies published during the last three years. this survey demonstrates that voriconazole has a broad antifungal spectrum against the most common fungal pathogens being its action fungistatic for candida and fungicidal for aspergillus and other filamentous fungi. o ... | 2007 | 17874856 |
| correlation of posaconazole minimum fungicidal concentration and time kill test against nine candida species. | we evaluated the in vitro activity of posaconazole against nine candida species using minimum fungicidal concentration (mfc) measurements and time-kill methods. | 2007 | 17875607 |
| pneumonia caused by candida krusei and candida glabrata in a patient with chronic myeloid leukemia receiving imatinib mesylate treatment. | in this report we describe a patient suffering from chronic myeloid leukemia (cml), who was treated for 4.5 years with imatinib and developed pneumonia caused by two candida species, i.e., c. krusei and c. glabrata. the patient was in complete hematologic remission and molecular analyses did not display the presence of tlr2-r752q, tlr4-d299g and tlr4-t399i polymorphisms that may predispose individuals to fungal infections. this case report indicates that in some patients, as previously observed, ... | 2008 | 17885950 |
| synthesis, antifungal and antimycobacterial activities of new bis-imidazole derivatives, and prediction of their binding to p450(14dm) by molecular docking and mm/pbsa method. | new bis-imidazole derivatives have been synthesized and their antifungal and antimycobacterial activity was determined. almost all compounds exhibited a moderate to good activity against two clinical isolates of candida albicans 3038 and candida glabrata 123. the same compounds showed an interesting killing activity against mycobacterium tuberculosis h(37)rv reference strain. docking procedures combined with molecular dynamics simulations in the mm/pbsa framework of theory were applied to predic ... | 2007 | 17888669 |
| new ethacridine derivatives as the potential antifungal and antibacterial preparations. | until the 20th century fungal infections were rather easy cured, and the need of new antifungal drugs was low. however, low choice of antifungal preparations, their toxicity, limited spectrum of action, and ability to produce resistant strains show the need of new effective medicines for systemic fungal diseases in nowadays. our goal of research was to synthesize new antimicrobial compounds containing three or more pharmacophores in one molecule. the initial 5-substituted-2-methylmercaptothiazol ... | 2007 | 17895642 |
| accumulation of cds nanoparticles by yeasts in a fed-batch bioprocess. | the yeasts schizosaccharomyces pombe and candida glabrata were successfully cultivated in a fed-batch process at cadmium levels up to 100 mg l(-1). s. pombe incorporated 20 mg c dg(-1) dry biomass within 24h. c. glabrata accumulated 8 mg c dg(-1) dry biomass in 24h. the higher cd uptake from s. pombe cells correlate with the elevated glucose concentrations during and at the end of the cultivation. analysis of the cells with energy-filtering transmission electron microscopy-element specific imagi ... | 2007 | 17900736 |
| antimicrobial activity of extracts of the lichen parmelia sulcata and its salazinic acid constituent. | the antimicrobial activity of the acetone, chloroform, diethyl ether, methanol, and petroleum ether extracts of the lichen parmelia sulcata and its salazinic acid constituent have been screened against twenty eight food-borne bacteria and fungi. all of the extracts with the exception of the petroleum ether extract showed antimicrobial activity against aeromonas hydrophila, bacillus cereus, bacillus subtilis, listeria monocytogenes, proteus vulgaris, yersinia enterocolitica, staphylococcus aureus ... | 2007 | 17913083 |
| the candida glabrata putative sterol transporter gene cgaus1 protects cells against azoles in the presence of serum. | the uptake of endogenous sterol from serum may allow candida glabrata to survive azole treatment. this study aims to determine the contribution of a sterol transporter that alters fluconazole sensitivity in the presence of serum. | 2007 | 17913716 |
| [is there a change in ecology of candida species incriminated in fungemia? a 7 years study at foch hospital]. | some candidemia studies have documented changes in epidemiology of candida species and some species were reported as emerging species. we conducted a study over a 6 years period and until 2005 we do not noticed any change in epidemiology of candida even if candida albicans still the most common species followed by candida glabrata. no increase of candidemia was observed from 2000 to 2005 and we observed a decrease during the year 2006, this fact have to be confirm and may be related to other dat ... | 2007 | 17919846 |
| oral candida colonization of human immunodeficiency virus infected subjects in turkey and its relation with viral load and cd4+ t-lymphocyte count. | the association of asymptomatic oral candida colonization with the markers of immunodeficiency and hiv is not clear yet. in addition, the prevalence of different candida species colonizing the oral cavity of hiv-infected patients in turkey remains unknown. to evaluate these subjects, oral rinse samples were taken from 64 hiv-positive individuals who have come to the department of microbiology and clinical microbiology, istanbul medical faculty for viral load and cd4(+) t-lymphocyte count measure ... | 2007 | 17944711 |
| intramural tracking in esophageal pseudodiverticulosis. | 2007 | 17957608 | |
| ascending pneumonia complicating endoscopic therapy of a pancreatic abscess. | 2007 | 17957611 | |
| lactobacillus fermentum ess-1 with unique growth inhibition of vulvo-vaginal candidiasis pathogens. | the aim of this study was to characterize human isolates of lactobacillus species for their capacity to interfere with the growth of different strains of candida species in vitro in the search for a potential probiotic. growth inhibition of candida species was screened using an agar-overlay method. inhibiting strains were selected to assay the effect of a cell-free lactobacillus culture filtrate (lcf) on the growth of isolates of candida albicans and candida glabrata. a total of 126 human lactob ... | 2007 | 17965352 |
| synthesis and spectral studies of organotin(iv) 4-amino-3-alkyl-1,2,4-triazole-5-thionates: in vitro antimicrobial activity. | some di- and triorganotin(iv) triazolates of general formula, r(4-n)snln (where n=2; r=me, n-bu and ph; n=1; r=me, n-pr, n-bu and ph and hl=4-amino-3-methyl-1,2,4-triazole-5-thiol (hl-1); and 4-amino-3-ethyl-1,2,4-triazole-5-thiol (hl-2)) were synthesized by the reaction of r(4-n)sncln with sodium salt of hl-1 and hl-2. the bonding and coordination behavior in these derivatives have been discussed on the basis of ir and 119sn mössbauer spectroscopic studies in the solid state. their coordination ... | 2008 | 17977061 |
| [species composition of yeast-like fungi isolated from hiv-infected patients]. | the strains of yeast-like fungi isolated from hiv-infected people in 1994-2005 were examined. it was found that a share of non-albicans strains increased up to 46.2%, in monoculture they were present in 40% of examined patients, candida glabrata (21.3%) being the dominant species. the definition of proteolytic activity as one of the factors of pathogenicity showed that it was typical of 90% of museum strains and 58% of fresh isolates. | 2007 | 17977446 |
| a rare case of acute renal failure due to massive renal allograft infiltration with candida glabrata. | 2008 | 17977879 | |
| multicenter evaluation of the candida albicans/candida glabrata peptide nucleic acid fluorescent in situ hybridization method for simultaneous dual-color identification of c. albicans and c. glabrata directly from blood culture bottles. | we evaluated the performance of the candida albicans/candida glabrata peptide nucleic acid fluorescent in situ hybridization (pna fish) method, a rapid two-color assay for detection of c. albicans and c. glabrata, in a multicenter study. the assay is designed for use directly from positive blood culture bottles in a fish format. intact, fixed cells are labeled fluorescent green (c. albicans) or fluorescent red (c. glabrata) by rrna hybridization of fluorophore-labeled pna probes. results are ava ... | 2008 | 17977998 |
| yarrowia lipolytica vesicle-mediated protein transport pathways. | protein secretion is a universal cellular process involving vesicles which bud and fuse between organelles to bring proteins to their final destination. vesicle budding is mediated by protein coats; vesicle targeting and fusion depend on rab gtpase, tethering factors and snare complexes. the génolevures ii sequencing project made available entire genome sequences of four hemiascomycetous yeasts, yarrowia lipolytica, debaryomyces hansenii, kluyveromyces lactis and candida glabrata. y. lipolytica ... | 2007 | 17997821 |
| epidemiological investigation and typing of candida glabrata clinical isolates by ftir spectroscopy. | candida glabrata has emerged as one of the leading agents of fungal infections and strain typing is essential for epidemiological investigation that is generally achieved by molecular techniques. in this work, we studied twenty-nine c. glabrata strains isolated from different patients, using a phenotypic approach based on fourier transform infrared (ftir) spectroscopy, which has been in a previous study successfully applied as a rapid typing method for candida albicans. a two-step procedure was ... | 2007 | 18022718 |
| therapy and outcome of candida glabrata versus candida albicans bloodstream infection. | candida glabrata is a common cause of bloodstream infection (bsi) and exhibits reduced susceptibility to antifungal agents. those with c. glabrata bsi may therefore be at increased risk for a delay in receiving appropriate therapy and poor treatment outcome. we compared treatment and outcome of patients with c. glabrata to controls with candida albicans bsi. each patient with c. glabrata bsi from july 1997 through december 2004 was matched with a control patient infected with c. albicans. approp ... | 2008 | 18024053 |
| biological consequences of statins in candida species and possible implications for human health. | the statins, simvastatin and atorvastatin are the most widely prescribed drugs. statins lower cholesterol levels through their action on hmg-coa (3-hydroxy-3-methylglutaryl-coa) reductase, an essential enzyme for the biosynthesis of cholesterol. fungal hmg-coa reductases are also inhibited by statins, resulting in reduced levels of ergosterol (the fungal equivalent of cholesterol) and concomitant growth inhibition. this effect occurs in a range of fungal species and possibly affects fungal colon ... | 2007 | 18031260 |
| characterization of a parainfluenza virus isolated from a bottlenose dolphin (tursiops truncatus). | a novel member of the parainfluenza virus family was identified in a bottlenose dolphin with respiratory disease. the case animal was a 19-year old male atlantic bottlenose dolphin (tursiops truncatus) that presented with signs of respiratory illness, including raspy, foul-odored breaths and cream-colored exudate from the blowhole. focally extensive pyogranulomatous bronchointerstitial pneumonia with moderate numbers of intralesional yeast organisms was identified on histopathological examinatio ... | 2008 | 18031960 |
| [aortoduodenal fistula revealed by acute fever with heavy and swollen red leg]. | aortoduodenal fistulas are rare and severe complications of aortic prostheses. the clinical picture usually includes digestive features and fever, unlike our observation where fistula was revealed by heavy and swollen leg with cutaneous septic abscesses but no digestive signs. | 2007 | 18033065 |
| rapid identification of candida glabrata in candida bloodstream infections. | candida species are the fourth most common cause of bloodstream infection (bsi) in the hospitalized patient. candida glabrata is the most common non-candida albicans candida species in england and wales with an attributed mortality of 48%. c. glabrata is known to demonstrate reduced susceptibility to fluconazole, resulting in treatment failures when employing this agent for empirical treatment of candida bsi. the first part of this study demonstrated a technique utilizing a blood culture system ... | 2007 | 18033833 |
| synthesis of new isoxazoles and dihydroisoxazoles and in vitro evaluation of their antifungal activity. | new 2-(2,4-dihalogenophenyl)-1-(1h-imidazol-1-yl)-3-(isoxazol-5-yl)propan-2-ols and 2-(2,4-dihalogenophenyl)-1-(1h-imidazol-1-yl)-3-(4,5-dihydroisoxazol-5-yl)propan-2-ols were synthesized by 1,3-dipolar cycloaddition between homopropargylic or homoallylic alcohols and in-situ generated nitrile oxide. their antifungal activity was evaluated against candida albicans, c. glabrata, aspergillus fumigatus and an azole-resistant petite mutant of c. glabrata. preliminary sar results are discussed. | 2007 | 18035824 |
| prevalence & susceptibility to fluconazole of candida species causing vulvovaginitis. | vulvovaginal candidiasis is an important cause of morbidity in women of reproductive age. this study was carried out to determine the species prevalence and susceptibility pattern to fluconazole of yeasts isolated from the vagina of symptomatic women. | 2007 | 18037716 |
| caspofungin as primary antifungal prophylaxis in stem cell transplant recipients. | to assess the effectiveness and tolerability of caspofungin as primary prophylaxis against invasive fungal infections in stem cell transplant recipients who are poor candidates for triazole or lipid amphotericin b prophylaxis due to renal or hepatic dysfunction, and to determine whether any patient characteristics are independently associated with an increased risk of breakthrough invasive fungal infection during caspofungin prophylaxis. | 2007 | 18041885 |
| candida glabrata fungaemia in intensive care units. | candidaemia is increasingly important in intensive care units (icus). compared with candida albicans fungaemia, the impact of c. glabrata fungaemia on icu patients is not well-known. the aim of this study was to investigate the clinical features, the antifungal susceptibility and the treatment outcomes of c. glabrata fungaemia in icu patients. the medical records of icu patients with candidaemia between 2000 and 2005 were reviewed retrospectively, and antifungal susceptibility testing was perfor ... | 2008 | 18042196 |
| activities of fluconazole and voriconazole against bloodstream isolates of candida glabrata and candida krusei: a 14-year study in a spanish tertiary medical centre. | the aim of this study was to evaluate the in vitro activities of voriconazole and fluconazole against candida glabrata and candida krusei isolated from blood during a 14-year period (1990-2003) at the tertiary care hospital of cruces (barakaldo, spain). the in vitro activities of fluconazole and voriconazole against 28 isolates of c. glabrata and 15 isolates of c. krusei were determined by the clinical and laboratory standards institute disk diffusion method. of the 28 c. glabrata isolates teste ... | 2008 | 18054468 |
| posaconazole activity against candida glabrata after exposure to caspofungin or amphotericin b. | we evaluated the effects of sequential therapy with caspofungin (cas) or amphotericin b (amb) followed by posaconazole (pos) against candida glabrata. the susceptibilities to pos of yeast cells pre-exposed to cas or amb were identical to those of untreated cells as shown by standard clinical and laboratory standards institute broth dilution, cell viability, and disk diffusion methods. we then investigated the activity of sequential regimens in an experimental model of disseminated candidiasis. c ... | 2008 | 18056279 |
| fluconazole prophylaxis against fungal colonization and invasive fungal infection in very low birth weight infants. | fungal infections are common cause of morbidity and mortality in very low birth weight infants | 2007 | 18057479 |
| antifungal susceptibility of bloodstream yeasts isolated at a public children's hospital in brazil: comparison of the etest and the afst-eucast microdilution method. | this study compared the minimum inhibitory concentration (mic) results from the proposed standard methods of the antifungal susceptibility testing subcommittee of the european committee on antibiotic susceptibility testing (afst-eucast) with the commercial system etest(r) in the evaluation of susceptibility to flucytosine, fluconazole, itraconazole, voriconazole, and amphotericin b of 136 candida spp. isolated from the blood of hospitalized children. the results presented a greater agreement amo ... | 2007 | 18059562 |
| comparative in vitro activities of caspofungin and micafungin, determined using the method of the european committee on antimicrobial susceptibility testing, against yeast isolates obtained in france in 2005-2006. | the in vitro activities of caspofungin and micafungin against 1,038 yeast isolates have been determined. the caspofungin and micafungin mics were lower for candida albicans, candida glabrata, and candida tropicalis than for candida parapsilosis, candida guilliermondii, and candida krusei. a clear correlation was seen between the mics for the two drugs. | 2008 | 18070978 |
| in vivo pharmacodynamic characterization of anidulafungin in a neutropenic murine candidiasis model. | multiple in vivo studies have characterized the pharmacodynamics of drugs from the triazole and polyene antifungal drug classes. fewer studies have investigated these pharmacodynamic relationships for the echinocandin drug class. we used a neutropenic murine model of disseminated candida albicans, candida tropicalis, and candida glabrata infection to characterize the time course of activity of the new echinocandin anidulafungin. the pharmacokinetic-pharmacodynamic (pk-pd) indices (the percentage ... | 2008 | 18070979 |
| potent anti-microbial activity of traditional chinese medicine herbs against candida species. | anti-candidial activities of eight traditional chinese medicinal (tcm) herbs were evaluated against six different candida species. tcm preparations were screened for antifungal activity using a standard agar diffusion assay. following identification of potential candidate herbs, their minimum inhibitory concentration (mic) values were determined using the standardised nccls m-27a broth microdilution assay. among tcm herbs, rhizoma coptidis had potent antifungal activity against candida glabrata, ... | 2008 | 18076592 |
| molecular epidemiology of candida species isolated from clinical specimens of intensive care unit patients. | epidemiological analysis of nosocomial candida infections has gained importance due to an increase in these infections during the recent years. this study investigated the prevalence of clinical infections of candida in anesthesiology intensive care unit patients, and ascertains the level of genetic diversity in the candida species. a total of 70 candida isolates, consisting of 42 candida albicans, 16 candida glabrata and 12 candida tropicalis strains isolated from various clinical sites of infe ... | 2008 | 18076594 |
| candida bracarensis detected among isolates of candida glabrata by peptide nucleic acid fluorescence in situ hybridization: susceptibility data and documentation of presumed infection. | molecular taxonomic studies have revealed new candida species among phenotypically delineated species, the best example being candida dubliniensis. this study was designed to determine the occurrence of two new molecularly defined species, candida bracarensis and candida nivariensis, which are closely related to and identified as candida glabrata by phenotypic assays. a total of 137 recent clinical isolates of c. glabrata identified by phenotypic characteristics was tested with c. bracarensis an ... | 2008 | 18077641 |
| complete mitochondrial genome sequence of the wine yeast candida zemplinina: intraspecies distribution of a novel group-iib1 intron with eubacterial affiliations. | the mtdna of the ascomycetous wine yeast candida zemplinina is a circularly mapping genome of 23,114 bp. it contains 35 genes coding for the seven basic subunits of oxidative phosporylation found in yeasts (the genes encoding for nadh oxidoreductase subunits are absent), the ribosomal protein var1, two rrnas and 25 trna genes. although protein phylogenetic analysis showed a divergent mitochondrial genome, several traits appeared preserved. the conserved gene blocks between the mtdnas of c. zempl ... | 2008 | 18081838 |
| increasing incidence of candida parapsilosis candidemia with caspofungin usage. | to determine the impact on the change in epidemiology of candida species at our institution since the introduction of caspofungin. | 2008 | 18082269 |
| increases in slt2 expression and chitin content are associated with incomplete killing of candida glabrata by caspofungin. | incomplete killing was observed for caspofungin against candida glabrata, which was associated with increased slt2 expression and elevated chitin content. in contrast, fungicidal activity and no chitin increase were observed in an isogenic delta slt2 strain, suggesting a role for slt2 and chitin production in the response of c. glabrata to caspofungin. | 2008 | 18086838 |