Publications
| Title | Abstract | Year Filter | PMID(sorted ascending) Filter |
|---|
| identificaiton of chlamydia penumoniae dna in caroitd plaques. | chlamydia pneumoniae (cp) is a bacterium that in recent years has been investigated as an etiologic agent for atherosclerosis. it is a ubiquitous microorganism that has been isolated in various regions of the vascular system and its prevalence is about 10% in the patient population. this study involved a group of 43 patients (27 men, 16 women, mean age 68 years) who underwent carotid endarterectomy. about 9.3% of the patients yielded plaques that tested positive for the dna genome of chlamydia p ... | 2000 | 11108326 |
| hyperinsulinemia, lipoprotein (a), and chlamydia pneumoniae antibodies--are they risk factors or serologic predictors for progression of coronary artery disease? | the authors studied 134 patients with unstable angina pectoris symptoms and 32 subjects without coronary artery disease (cad) for the presence of classical risk factors such as hypercholesterolemia, smoking, and family history of cad. in addition they analyzed plasma insulin levels, lipoprotein (a) (lp [a]) levels, and antibody titers against chlamydia pneumoniae. all patients had a heart catheterization. patients with diabetes mellitus were excluded from the study. fasting insulin, low-density ... | 2000 | 11108327 |
| chlamydia pneumoniae does not influence atherosclerotic plaque behavior in patients with established carotid artery stenosis. | research for infectious agents in the etiology of atherosclerosis has identified chlamydia pneumoniae as a possible candidate. while there is evidence of an association between presence of this microorganism and atherosclerosis, it is unclear whether infection has a genuinely etiologic role in this disease, whether its presence influences clinical outcomes, and, if so, at which stages of disease this occurs. we have approached this issue in patients with advanced carotid artery atherosclerosis u ... | 2000 | 11108751 |
| a new dig-pcr-eia method for the detection of chlamydia pneumoniae dna in clinical samples. | chlamydia pneumoniae, a common respiratory pathogen, may also play a role in the pathogenesis of other chronic conditions. for accurate detection of infected persons and verification of results obtained by other pcr methods, a dig-pcr-eia method was evaluated. in the dig-pcr-eia, a 437 bp dna sequence was amplified and hybridized with a newly synthesized 229 bp biotin-labeled probe. the end product was detected by an enzyme immunoassay. the sensitivity of dig-pcr-eia was compared with southern b ... | 2000 | 11110051 |
| possible role of chronic infection with chlamydia pneumoniae in japanese patients with acute myocardial infarction. | chlamydia pneumoniae, a common human respiratory pathogen, has been implicated in the pathogenesis of coronary heart diseases (chd) in several seroepidemiological studies. the present case-control study investigated the relation between serologic evidence of c. pneumoniae infection and chd in a japanese population. two groups of cases were enrolled: 26 patients with acute myocardial infarction (ami) and 46 patients with effort angina pectoris (e-ap). their data were compared with 58 age-matched ... | 2000 | 11110424 |
| characterization and functional analysis of porb, a chlamydia porin and neutralizing target. | a predicted protein (ct713) with weak sequence similarity to the major outer membrane protein (20.4% identity) in chlamydia trachomatis was identified by chlamydia genome analysis. we show that this protein is expressed, surface accessible, localized to the chlamydial outer membrane complex and functions as a porin. this protein, porb, was highly conserved among different serovars, with nearly identical sequences between serovars d, b, c and l2. sequence comparison between c. trachomatis and chl ... | 2000 | 11115112 |
| sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease. | endothelin (et)-l is a bronchoconstrictor peptide produced in the airways. it has been implicated in the pathogenesis of asthma and virally mediated airway inflammation and may play a role in exacerbations of chronic obstructive pulmonary disease (copd). | 2001 | 11120901 |
| atherosclerosis in apoe knockout mice infected with multiple pathogens. | cytomegalovirus (cmv) and chlamydia pneumoniae (cp) possibly contribute to atherosclerosis. murine cmv (mcmv) and cp increase lesion size in apoe knockout mice. in this study, apoe knockout mice were infected with mcmv and cp to determine whether infection with multiple pathogens increases lesion size to a greater extent than either pathogen alone and whether infection with mcmv changes serum cytokine levels in a manner that could increase lesion development. one group of mice received mcmv at 2 ... | 2001 | 11120928 |
| effect of azithromycin on murine arteriosclerosis exacerbated by chlamydia pneumoniae. | chlamydia pneumoniae infection can exacerbate atherosclerosis in animals. to test the hypothesis that antibiotic therapy inhibits the atherogenic effects of c. pneumoniae infection, 10-week-old apolipoprotein e (apoe) null mice were infected with c. pneumoniae or placebo, were treated for 2 weeks after infection with azithromycin or placebo, and were killed at 20 weeks of age. infection did not affect the size of the aortic lesion, and antibiotic treatment had no effect. another group of mice, 1 ... | 2001 | 11120929 |
| a preliminary evaluation of a new enzyme immunoassay to detect chlamydia pneumoniae-specific antibodies. | new enzyme immunoassays (eias) for determination of specific igg, iga, and igm antibody titers to chlamydia pneumoniae were evaluated independently in three research laboratories. specificity of the eias was enhanced by removing lps from the chlamydial antigen. the performance of these eias was evaluated in comparison with the microimmunofluorescence (mif) test using specimens from: (i) a group of adult patients with community-acquired pneumonia (cap) previously diagnosed as having an acute chla ... | 2000 | 11121610 |
| acute myocardial infarction and prior antibiotic use. | 2000 | 11122585 | |
| inflammation and immune response in atherosclerosis. | atherosclerosis is an inflammatory disease with a significant autoimmune component. studies using transgenic murine models have clarified that recruitment of mononuclear leukocytes through vascular leukocyte-adhesion molecules and chemokines, differentiation of monocytes to macrophages, and endocytosis through scavenger receptors all are of decisive importance for atherosclerosis in hypercholesterolemic mice. t and b cells modulate disease progression and lesion development is reduced in mice la ... | 1999 | 11122704 |
| chlamydia pneumoniae and atherosclerosis. | chlamydia pneumoniae (c. pneumoniae) is a common respiratory pathogen. many reports have documented the presence of c. pneumoniae in atheromatous coronary arteries, aorta, carotid arteries, and peripheral arteries using a variety of techniques. there is clear experimental evidence that c. pneumoniae can infect macrophages, endothelial cells, smooth muscle cells, and induce the formation of foam cells. evidence from basic research and epidemiologic studies suggest that c. pneumoniae can induce ma ... | 2000 | 11122747 |
| development and assessment of antiatherosclerotic therapies beyond low-density lipoprotein cholesterol and blood pressure. | 2000 | 11122754 | |
| antibiotic therapy for treatment of chlamydia to prevent coronary heart disease events. | evidence is mounting that infectious agents might be involved in atherosclerosis. therefore, antibiotic therapy might be helpful in its prevention. early pilot therapeutic trials have targeted chlamydia pneumoniae because it has the most evidence associating it with atherosclerosis. small, randomized pilot trials that test the effect of macrolide therapy on future clinical events in patients with coronary artery disease have already shown promising but mixed results. large clinical trials are pr ... | 2000 | 11122763 |
| the association of chronic cough with the risk of myocardial infarction: the framingham heart study. | 2000 | 11126316 | |
| [clinical relevance of chlamydia pneumoniae infection--from the respiratory tract to the vascular system]. | 2000 | 11132549 | |
| prospective study of pathogen burden and risk of myocardial infarction or death. | we previously demonstrated that the risk of coronary artery disease (cad) increased in relation to the number of pathogens (the "pathogen burden") in a cross-sectional study. in the present prospective study with a different patient cohort, we evaluated the effect of pathogen burden on the risk of myocardial infarction (mi) or death among cad patients. | 2001 | 11136684 |
| immunity to chlamydia pneumoniae induced by vaccination with dna vectors expressing a cytoplasmic protein (hsp60) or outer membrane proteins (momp and omp2). | immune responses induced by intramuscular dna immunization with chlamydia pneumoniae genes coding for the major outer membrane protein (momp), cysteine-rich outer membrane protein 2 (omp2) or the heat shock protein 60 (hsp60) were studied. balb/c mice were vaccinated intramuscularly three times at 3-week intervals and challenged intranasally 2 weeks after the last injection. immunization with pmomp or phsp60 showed 1.2-1.5 log reduction in the mean lung bacterial counts after the challenge. spec ... | 2000 | 11137265 |
| association between c-reactive protein, anti-chlamydia pneumoniae antibodies, and vascular function in healthy adults. | abnormalities of vascular function occur in patients with risk factors for atherosclerosis before the development of obstructive disease. our pilot data suggest that elevated serum markers of infection and/or inflammation are associated with functional abnormalities of the vasculature in subjects at otherwise low risk for atherosclerosis. | 2001 | 11137849 |
| [chest radiograph of atypical pneumonia: comparison among chlamydia pneumoniae. pneumonia, ornithosis, and mycoplasma pneumoniae pneumonia]. | no report has been found comparing chlamydia pneumoniae (c. pneumoniae) pneumonia radiographically with other atypical pneumonias, chlamydia psittaci (c. psittaci) pneumonia and mycoplasma pneumoniae (m. pneumoniae) pneumonia. we described the chest radiographs of three kinds of pneumonia cases: 46 cases of c. pneumoniae pneumonia, 39 cases of c. psittaci pneumonia, and 131 cases of m. pneumoniae pneumonia. radiographic shadows were categorized into main shadows and sub-shadows. the main shadows ... | 2000 | 11140079 |
| chlamydia pneumoniae proteins induce secretion of the 92-kda gelatinase by human monocyte- derived macrophages. | chlamydia pneumoniae, an intracellular gram-negative respiratory bacterium, and macrophages are present in inflammatory tissue sites such as atherosclerotic lesions, where abnormal degradation of the extracellular matrix takes place. to evaluate the potential of c pneumoniae for participation in matrix destruction, we studied the effect of this bacterium on the production of 3 matrix-degrading metalloproteinases, 92-kda gelatinase, interstitial collagenase-1, and stromelysin-1, and their natural ... | 2001 | 11145952 |
| chlamydia pneumoniae and the lung. | chlamydia pneumoniae is a frequently occurring respiratory pathogen affecting all age groups. it may cause 5-20% of community-acquired pneumonias in adults and children. the organism has also been implicated as an infectious trigger for asthma. furthermore, new studies suggest that it may play a role in the pathogenesis of several chronic diseases including atherosclerosis. however, despite the growing significance of c. pneumoniae as a pathogen, progress is hampered by the lack of standardized ... | 2000 | 11153568 |
| recent developments in pulmonary infections. | 2000 | 11153574 | |
| [resistance and new antibiotic strategies. new antistaphylococcal antibiotics]. | injectable spectrogramin: combination regimens using quinupristin/dafopristin with either gentamicin or vancomycin have powerful bactericidal activities (even against quinupristin-resistant strains) against methicillin-resistant staphylococcus aureus (mrsa) in a model of experimental endocarditis in the rabbit. in clinical trials, quinupristin/dalfopristin is becoming a therapeutic alternative to consider after failure of conventional antistaphylococcal treatments. new generation cephalosporins: ... | 2000 | 11155724 |
| chlamydia pneumoniae infection in circulating human monocytes is refractory to antibiotic treatment. | recovery of the intracellular bacterium chlamydia pneumoniae from atherosclerotic plaques has initiated large studies on antimicrobial therapy in coronary artery disease. the basic concept that antibiotic therapy may eliminate and prevent vascular infection was evaluated in vitro and in vivo by examining the antibiotic susceptibility of c pneumoniae in circulating human monocytes, which are thought to transport chlamydiae from the respiratory tract to the vascular wall. | 2001 | 11157684 |
| in vitro activity of midecamycin diacetate against mycoplasma pneumoniae and chlamydia pneumoniae. | 2001 | 11157917 | |
| multicenter comparison trial of dna extraction methods and pcr assays for detection of chlamydia pneumoniae in endarterectomy specimens. | the reported rate of detection of chlamydia pneumoniae dna within atherosclerotic lesions by pcr varies between 0 and 100%. in this study, identical sets of coded experimental atheroma samples (n = 15) and spiked controls (n = 5) were analyzed by 16 test methods in nine centers by means of pcr. the positive controls were correctly identified to levels of 1, 0.1, and 0.01 inclusion bodies of c. pneumoniae/ml of tissue homogenate by 16 (100%), 11 (69%), and 3 (19%) of the test methods, respectivel ... | 2001 | 11158100 |
| circulating nucleic acids of chlamydia pneumoniae and cytomegalovirus in patients undergoing coronary angiography. | peripheral blood mononuclear cells from 208 consecutive patients undergoing elective coronary angiography or angioplasty were collected before, immediately after, and 4 h after the procedure. nucleic acids of chlamydia pneumoniae and of cytomegalovirus (cmv) were detected by pcr and confirmed by hybridization. circulating c. pneumoniae dna was identified in 24 patients (11.5%) and was associated with current smoking (odds ratio [or] = 4.5, 95% confidence interval [ci] = 1.6 to 12.2, p = 0.004) b ... | 2001 | 11158113 |
| rapid, transient phosphatidylserine externalization induced in host cells by infection with chlamydia spp. | chlamydia organisms are obligate intracellular bacterial pathogens responsible for a range of human diseases. persistent infection or reinfection with chlamydia trachomatis leads to scarring of ocular or genital tissues, and chlamydia pneumoniae infection is associated with the development of atherosclerosis. we demonstrate that c. trachomatis and c. pneumoniae infection in vitro elicits the externalization of the lipid phosphatidylserine on the surface of human epithelial, endothelial, granuloc ... | 2001 | 11160008 |
| the role of inflammation and infection in coronary artery disease. | new insights into atherosclerosis, the most common disease affecting coronary arteries, may change therapeutic strategies from largely symptomatic to causal. atherosclerotic plaques contain a lipid-related, immune-mediated inflammation, with release of secretory products capable of changing plaque morphology. plaques prone to complications contain large numbers of inflammatory cells; stable plaques contain little inflammation. similarly, atherectomy specimens from patients with coronary syndrome ... | 2001 | 11160780 |
| gene conversions in genes encoding outer-membrane proteins in h. pylori and c. pneumoniae. | helicobacter pylori and chlamydia pneumoniae are both pathogenic to humans. their genomes have recently been completed, allowing detailed study of their evolution and organization. here we describe an evolutionary analysis of the h. pylori and c. pneumoniae genes that encode their outer-membrane proteins. by comparing complete genome sequences of two h. pylori strains and two c. pneumoniae strains, we identify multiple independent conversions among these genes. such recombination events might pr ... | 2001 | 11163905 |
| antibodies to chlamydia pneumoniae and clinical course in patients with unstable angina pectoris. | inflammation is one of the most important mechanisms that contribute to coronary artery disease (cad). one of the micro-organisms that is mentioned as a source of the inflammation is chlamydia pneumoniae. in this study, we investigated the relationship between titres of igg and iga antibodies to c. pneumoniae and the clinical course, during hospitalisation and during an 18-month follow-up, in 211 patients admitted to hospital with unstable angina pectoris. slightly more patients who were refract ... | 2000 | 11164440 |
| secretion of predicted inc proteins of chlamydia pneumoniae by a heterologous type iii machinery. | chlamydia spp. are strictly intracellular pathogens that grow inside a vacuole, called an inclusion. they possess genes encoding proteins homologous to components of type iii secretion machineries, which, in other bacterial pathogens, are involved in delivery of bacterial proteins within or through the membrane of eukaryotic host cells. inc proteins are chlamydial proteins that are associated with the inclusion membrane and are characterized by the presence of a large hydrophobic domain in their ... | 2001 | 11169118 |
| chlamydia outer membrane protein discovery using genomics. | outer membrane proteins of microbial pathogens serve essential roles in engaging the host environment and can be important immunotherapeutic targets. because of the difficulty of growing large quantities of chlamydiae suitable for biochemical fractionation, little was known about their outer membrane protein composition prior to the recent sequencing of the c. trachomatis and c. pneumoniae genomes. using bioinformatic approaches to characterize chlamydial open reading frames, novel outer membran ... | 2001 | 11173028 |
| plaque disruption and thrombosis: potential role of inflammation and infection. | acute coronary syndromes (unstable angina, acute myocardial infarction, and ischemic sudden death) result from coronary thrombosis superimposed on an atherosclerotic plaque. thrombosis is generally a consequence of disruption of the atherosclerotic plaque in the form of a fissure/rupture in the fibrous cap overlying a lipid-rich pool or superficial endothelial erosion covering a smooth muscle and proteoglycan-rich matrix with or without a lipid-core. approximately 2/3 of acute coronary syndromes ... | 2000 | 11174871 |
| seroetiology of acute lower respiratory infections among hospitalized children in beijing. | little is known of the etiology of childhood acute lower respiratory infections in china, where the use of antimicrobials is indiscriminate. trials to change such a policy require etiologic data, especially on the bacteria most relevant to these common diseases. | 2001 | 11176567 |
| failure to demonstrate chlamydia pneumoniae in cardiovascular tissue from children with kawasaki disease. | chlamydia pneumoniae has been associated with atherosclerosis and myocardial infarction in adults. coronary artery tissues of five fatal cases of kawasaki disease were examined by pcr; none was positive. | 2001 | 11176572 |
| not so fast: research on infectious links to ms questioned. | 2001 | 11176824 | |
| telithromycin: a new ketolide antimicrobial for treatment of respiratory tract infections. | telithromycin is a new ketolide antimicrobial, specifically developed for the treatment of community-acquired respiratory tract infections. it has a wide spectrum of antibacterial activity against common respiratory pathogens including streptococcus pneumoniae, haemophilus influenzae, moraxella catarrhalis and streptococcus pyogenes. it also has activity against atypical pathogens, such as chlamydia pneumoniae, legionella pneumophila and mycoplasma pneumoniae. telithromycin maintains activity ag ... | 2001 | 11178347 |
| cytomegalovirus, chlamydia pneumoniae, and helicobacter pylori igg antibodies and restenosis after stent implantation: an angiographic and intravascular ultrasound study. | to determine the impact of previous infection with cytomegalovirus, chlamydia pneumoniae, and helicobacter pylori on neointimal proliferation after coronary angioplasty with stent implantation. | 2001 | 11179272 |
| cdna array analysis of altered gene expression in human endothelial cells in response to chlamydia pneumoniae infection. | strong epidemiological and pathological evidence supports a role for chlamydia pneumoniae infection in atherosclerosis and human coronary heart disease. animal models have shown that c. pneumoniae disseminates hematogenously in infected monocytes and macrophages, while in vitro data suggest that infected macrophages can transmit c. pneumoniae infection directly to endothelial cells. endothelial cells may be key in vivo targets for c. pneumoniae infection; given that these cells are important in ... | 2001 | 11179307 |
| acute chest syndrome in sickle cell disease. | 2000 | 11183562 | |
| mycoplasma fermentans, m. hominis, and m. hyorhinis inhibit infectivity and growth of chlamydia trachomatis and c. pneumoniae in hep-2 cells. | 2000 | 11184179 | |
| in vitro activity of gar-936 against chlamydia pneumoniae and chlamydia trachomatis. | we evaluated the in vitro activity of gar-936, a novel glycylcycline antibiotic, against ten isolates of chlamydia pneumoniae and five strains of c. trachomatis. susceptibility testing was done in hep-2 cells. the mic90s and mbc90s of gar-936, doxycycline, ofloxacin and clarithromycin against c. pneumoniae were 0.125, 0.25, 0.25 and 0.06 mg/l, respectively. the mics and mbcs of gar-936, doxycycline, ofloxacin and clarithromycin against c. trachomatis were 0.03-0.125, 0.25, 0.25-0.5 and 0.06 mg/l ... | 2000 | 11185415 |
| [is infection a pathogenetic factor in coronary heart disease?]. | several wellknown risk-factors can contribute to the development of coronary artery disease. a relatively new question is whether infection is also involved in the pathogenesis. acute and/or chronic infections might affect initiation, progression and instability in coronary artery disease, as well as enhance development of restenosis and transplant atherosclerosis. in clinical studies it is possible to measure the amount of antibodies in blood samples, detect infectious agents in atheromatous le ... | 2000 | 11187193 |
| acute respiratory tract infections in indian children with special reference to mycoplasma pneumoniae. | a total of 70 indian children of either sex and under 5 years of age who were admitted to the all india institute of medical sciences, new delhi during a 1-year period (january 1994-december 1994) with complaints suggestive of acute respiratory tract infections (arti), were investigated for bacterial aetiology of infection with special reference to mycoplasma pneumoniae. microbial aetiology could be established in 44/70 (62.8 per cent) of cases of arti. mycoplasma pneumoniae infection was seen i ... | 2000 | 11191152 |
| coronary artery disease: an inflammatory or infectious process. | it is well accepted that coronary artery disease is linked to an inflammatory process. it is unknown which agents may cause or accelerate coronary artery disease. an inflammation of the vessel wall may be caused by a number of mechanisms such as accumulation of glycosylated proteins in diabetic patients, oxidised ldl in patients with hypercholesterolemia or infectious agents. among the possible infectious agents chlamydia pneumoniae is the most likely microorganism involved in atherosclerosis. t ... | 2000 | 11192355 |
| [comparison of the morphology and the reactivity of chlamydia pneumoniae isolated in north-kanto area, ibaraki prefecture, japan]. | to compare the morphology among chlamydia pneumoniae (c. pneumoniae), strain tw183 and strains which were isolated in the area of kasumigaura, ibaraki from 1992 to 1995. c. pneumoniae were infected on hl cell monolayers and cultured in 5% co2 at 35.5 degrees c for about 60 hrs. the cells were harvested and fixed with 2.5% glutaraldehyde, and then the regular procedure for observation of chlamydia in inclusion by transmission electron microscope was performed. immunoblot assay was carried out by ... | 2000 | 11193553 |
| seroprevalence of chlamydia pneumoniae infection in thailand. | chlamydia pneumoniae (c. pneumoniae) is an emerging infectious agent, with a spectrum of clinical manifestations, and it has recently been tentatively linked to atherosclerosis. in order to describe the seroprevalence of c. pneumoniae in thailand, we evaluated 1,798 normal healthy subjects (aged 20-93 years) for anti-c. pneumoniae igg and iga. specific antibodies were measured by the fully automated elisa method using elementary bodies of c. pneumoniae as an antigen. igg antibodies against c. pn ... | 2000 | 11193998 |
| [chlamydia pneumoniae and its relation with human atherosclerosis]. | 2000 | 11195174 | |
| [the role of infection in the development of immune inflammation and pathogenesis of atherosclerosis]. | pathogenesis of atherosclerosis from the point of view of immune inflammation in the vascular wall is discussed in this review. potential role of adenoviruses and chlamydia in the development of immune inflammation and mechanisms and transport of infectious agents into the vascular wall and their influence on the cell kinetics are reviewed. | 2000 | 11198124 |
| chlamydia pneumoniae-specific humoral immune responses and clinical disease parameters in multiple sclerosis. | 2001 | 11198285 | |
| the pathology of chlamydia pneumoniae lesions in humans and animal models. | 2000 | 11201259 | |
| [association of serology with the endovascular presence of chlamydia pneumoniae and cytomegalovirus in coronary artery and vein graft disease]. | 2000 | 11204018 | |
| chlamydia pneumoniae infection significantly exacerbates aortic atherosclerosis in an ldlr-/- mouse model within six months. | we have previously shown that infection with the c. pneumoniae ar39 strain once monthly for 9 consecutive months significantly exacerbated atherosclerosis in mice with ldl receptor deficiency (ldlr-/-) in the presence of a high cholesterol diet. to further optimize the ldlr-/- mouse model for studying the mechanisms of c. pneumoniae atherogenesis, we have tested a different infection protocol with intranasal inoculation twice monthly for 6 consecutive months in the present study. we found that c ... | 2000 | 11204447 |
| detection of seroconversion and persistence of chlamydia trachomatis antibodies in five different serological tests. | microimmunofluorescence (mif), a chlamydia trachomatis species-specific enzyme immunoassay incorporating lipopolysaccharide-extracted chlamydia trachomatis l2 elementary bodies, two different synthetic peptide-based species-specific tests, and a recombinant lipopolysaccharide genus-specific test were performed on multiple follow-up sera (n = 104 total) from 16 women with chlamydia trachomatis-positive cervical swabs. these women included five with igg seroconversions, five with chlamydia trachom ... | 2000 | 11205630 |
| inverse association of chlamydia pneumoniae infection with high blood pressure in japanese adults. | to determine whether chlamydia pneumoniae (c. pneumoniae) infection is associated with hypertension in japanese adults, we measured serum levels of iga (a marker of reinfection) and of igg (a marker of previous infection) antibodies to c. pneumoniae by enzyme-linked immunosorbent assay in 112 adults including normotensive and untreated hypertensive subjects and in 117 hypertensive subjects who had been receiving treatment for more than 3 years. in 112 adults, positivity rate for iga was lower (p ... | 2001 | 11206673 |
| the etiologies, pathophysiology, and alternative/complementary treatment of asthma. | a chronic inflammatory disorder of the respiratory airways, asthma is characterized by bronchial airway inflammation resulting in increased mucus production and airway hyper-responsiveness. the resultant symptomatology includes episodes of wheezing, coughing, and shortness of breath. asthma is a multifactorial disease process with genetic, allergic, environmental, infectious, emotional, and nutritional components. the underlying pathophysiology of asthma is airway inflammation. the underlying pr ... | 2001 | 11207455 |
| characterization and intracellular trafficking pattern of vacuoles containing chlamydia pneumoniae in human epithelial cells. | chlamydiae are obligate intracellular pathogens that reside within a membrane-bound vacuole throughout their developmental cycle. in this study, the intraphagosomal ph of chlamydia pneumoniae (cpn) was qualitatively assessed, and the intracellular fate of the pathogen-containing vacuole and its interaction with endocytic organelles in human epithelial cells were analysed using conventional immunofluorescence and confocal microscopy. the ph-sensitive probes acridine orange (ao), lysotracker (lyt) ... | 1999 | 11207556 |
| a secondary structure motif predictive of protein localization to the chlamydial inclusion membrane. | chlamydiae are obligate intracellular pathogens that spend their entire growth phase sequestered in a membrane-bound vacuole called an inclusion. a set of chlamydial proteins, labelled inc proteins, has been identified in the inclusion membrane (im). the predicted inca, incb and incc amino acid sequences share very limited similarity, but a common hydrophobicity motif is present within each inc protein. in an effort to identify a relatively complete catalogue of chlamydia trachomatis proteins pr ... | 2000 | 11207561 |
| prospective study of the incidence, aetiology and outcome of adult lower respiratory tract illness in the community. | acute lower respiratory tract illness in previously well adults is usually labelled as acute bronchitis and treated with antibiotics without establishing the aetiology. viral infection is thought to be the cause in most cases. we have investigated the incidence, aetiology, and outcome of this condition. | 2001 | 11209098 |
| [chlamydia pneumoniae and vascular pathology]. | an updating of the microbiological and diagnostic characteristics of chlamydia pneumoniae is carried out, and a hypothesis formulated for its probable role in the production of the atheromatous plaque. furthermore, the immunological results obtained from patients with peripheral vascular pathology, pneumonia from c. pneumoniae, or other genital processes from c. trachomatis, and a healthy control group are included. the presence of c. pneumoniae was revealed by pcr techniques in biopsies from pa ... | 2000 | 11209550 |
| infectious agents in coronary lesions obtained by endatherectomy: pattern of distribution, coinfection, and clinical findings. | cytomegalovirus (cmv), chlamydia pneumoniae (c. pneumoniae), and helicobacter pylori (h. pylori) have been implicated in atherosclerosis and restenosis after angioplasty. the patterns of distribution within coronary lesions and possible coinfections of these pathogens in the coronary vasculature had not previously been evaluated. | 2001 | 11211160 |
| acute exacerbations in chronic obstructive pulmonary disease (copd)--microbial patterns and risk factors. | around 25% of patients with stable chronic obstructive pulmonary disease (copd) show some evidence of tracheobronchial colonization. it is, however, probable that the vast majority of patients become colonized at some time during the course of the disease. a variety of factors including current smoking and viral infections predispose to bacterial colonization and subsequently acute exacerbations. in fact, infectious aetiologies account for around 50-75% of acute copd exacerbations. bacterial pat ... | 2000 | 11213381 |
| [importance of mycoplasma pneumoniae and chlamydia pneumoniae in children with community-acquired pneumonia]. | to determine the importance of mycoplasma pneumoniae and chlamydia pneumoniae in community-acquired pneumonia (cap) of children from different latitudes and to compare clinical outcome using azithromycin (azm) versus either amoxicillin-clavulanate (a-c) or erythromycin estolate (ee). | 1998 | 11214557 |
| chlamydia pneumoniae dna in peripheral blood mononuclear cells in peritoneal dialysis patients. | the aim of the present study was to examine the association between infection with chlamydia pneumoniae and symptomatic atherosclerosis in peritoneal dialysis (pd) patients. | 2000 | 11216566 |
| [pneumonia caused by chlamydophila (chlamydia) pneumoniae: clinical data, diagnosis, and therapy]. | 2001 | 11221081 | |
| [chlamydia pneumoniae and helicobacter pylori infections in acute myocardial infarction]. | increasing evidence suggests an acute or chronic linkage between infection and acute coronary syndromes. the aim of this study was to assess the frequency of chlamydia pneumoniae (cp) and helicobacter pylori (hp) antibodies in patients with angiographically defined acute myocardial infarction and in population controls. case patients and controls were drawn from the same geographic area (city of messina and its province). | 2000 | 11221586 |
| the genesis of atherosclerosis and risk factors: a review. | atherosclerosis constitutes the most common medical and surgical problem. this can be manifested clinically as stroke, coronary artery disease, or peripheral vascular disease. in the present review the microscopic appearance of the normal arterial wall, the definition of atherosclerosis and the five theories of atherogenesis are described. these are: the lipid theory, the hemodynamic theory, the fibrin incrustation theory, the nonspecific mesenchymal hypothesis and the response to injury hypothe ... | 2001 | 11228092 |
| chlamydia pneumoniae and screening for tubal factor subfertility. | chlamydia antibody testing (cat) by micro-immunofluorescence (mif) tests has been introduced into the fertility work-up as a screening test for tubal factor subfertility. in this study the role of c. pneumoniae antibodies, as a cause for false positive cat results due to cross-reactivity with c. trachomatis antibodies in the mif test, has been evaluated. in 240 subfertile women serological data were compared to laparoscopy findings. the prevalence of c. pneumoniae antibodies using enzyme-linked ... | 2001 | 11228216 |
| current infection with helicobacter pylori, but not seropositivity to chlamydia pneumoniae or cytomegalovirus, is associated with an atherogenic, modified lipid profile. | infectious agents may be involved in atherothrombogenesis. the potential pathogenic pathway, however, remains unclear. we investigated the association between various infectious agents and lipoproteins known to have an atherogenic effect. we recruited 470 healthy blood donors and 238 patients with angiographically proven coronary heart disease (chd), aged 40 to 68 years. seropositivity to chlamydia pneumoniae (cp), chlamydial lipopolysaccharide, and cytomegalovirus (cmv) was determined; infectio ... | 2001 | 11231924 |
| influence of iron restriction on chlamydia pneumoniae and c. trachomatis. | iron is an essential metabolite for pathogenic bacteria, and the specificity exhibited by bacteria for host-iron chelates may be correlated with host and tissue tropism. the effect of iron restriction on chlamydia pneumoniae and c. trachomatis was studied by use of the iron-chelating compound deferoxamine. growth of c. pneumoniae was inhibited much more than that of c. trachomatis and the effect of iron restriction largely depended on the cell line used for propagation. this might reflect differ ... | 2001 | 11232766 |
| search for chlamydia pneumoniae genes and their expression in atherosclerotic plaques of carotid arteries. | samples of atherosclerotic tissue from 58 patients undergoing carotid surgery were analysed by tissue culture and pcr for chlamydia pneumoniae; pcr was performed to detect omp1, 16s rrna and hsp-70 genes. to understand the active pathogenic role of c. pneumoniae, a reverse transcriptase-pcr (rt-pcr) assay was applied to detect the specific rnas expressed either in the replicative form, or in the cryptic form found in chronic infection. the c. pneumoniae omp1 gene, encoding the major outer-membra ... | 2001 | 11232767 |
| demonstration of chlamydia pneumoniae in the adenoid from children with and without secretory otitis media using immunohistochemistry and pcr. | chlamydia pneumoniae has been found in patients with middle ear inflammation. the adenoid, which has a central role in the development of secretory otitis media (som), may act as a reservoir for bacteria causing ear infection. adenoid tissue was examined for the presence of c. pneumoniae. twenty children undergoing adenoidectomy because of hyperplastic adenoids, 10 with som and 10 without som, were examined with nasopharyngeal swabs for routine bacteriological culture, serology for c. pneumoniae ... | 2001 | 11233849 |
| [chlamydia infections in neurology]. | 2001 | 11233885 | |
| chlamydia pneumoniae in children undergoing adenoidectomy. | chlamydia pneumoniae is a common respiratory pathogen which is often found in paediatric populations. little is known about the true colonization rate and the localization of the bacteria in the respiratory tract. in this study, immunohistochemistry was used to examine adenoids from 69 children undergoing elective adenoidectomy. throat swabs for polymerase chain reaction (pcr) and blood samples for serology were also obtained. chlamydia pneumoniae was demonstrated in the adenoids by immunohistoc ... | 2001 | 11236038 |
| [antibiotic treatment in myocardial infarction?]. | 2001 | 11236528 | |
| persistent airflow limitation in adult-onset nonatopic asthma is associated with serologic evidence of chlamydia pneumoniae infection. | persistent airflow limitation may develop in patients with asthma, particularly in adults with nonatopic (intrinsic) disease. although the underlying mechanisms are still unknown, respiratory infections might be involved. | 2001 | 11240944 |
| [the relation between carotid ultrasound changes and seropositivity to chlamydia pneumoniae in patients with acute stroke]. | several infectious agents have been found to be involved in atherogenesis over the past decade. chlamydia pneumoniae is one of the commonest associated agents. in this study we have analysed the possible relationship between a high level of antibodies to chlamydia, and the presence of carotid ultrasound changes in patients who have had strokes. | 2000 | 11244686 |
| enhanced progression of early carotid atherosclerosis is related to chlamydia pneumoniae (taiwan acute respiratory) seropositivity. | chlamydia pneumoniae (cp) infection has been associated with atherosclerosis and has been proposed as a possible additional cardiovascular risk factor. however, the relationship between cp seropositivity and the progression of early carotid atherosclerosis is not unequivocally clarified. | 2001 | 11245642 |
| chlamydia pneumoniae is associated with graft dysfunction after lung transplantation. | 2001 | 11250270 | |
| cardiac allograft vasculopathy in heart transplant recipients: a bacteriosclerosis by chlamydia pneumoniae? | 2001 | 11250340 | |
| comparison of a new commercial eia kit and the microimmunofluorescence technique for the determination of igg and iga antibodies to chlamydia pneumoniae. | chlamydia pneumoniae infection is often diagnosed by analyzing specific antibodies to c. pneumoniae in sera. the method which has been used as the reference method, or "gold standard", the microimmunofluorescence test (mif), demands a high level of experience for proper interpretation. a number of commercial enzyme immunoassay (eia) tests have been introduced to the market in the past few years. these provide objective reading of titers, but are genus specific and not species specific. the lates ... | 2000 | 11252815 |
| [chlamydia pneumoniae and myocardial infarction (clinf). preliminary randomized controlled study with clarithromycin. clainf protocol]. | 2000 | 11253326 | |
| [ischemic cardiovascular diseases. correlation with helicobacter pylori infection]. | coronary heart disease is the primary cause of mortality in western countries. the well-established ("classical") risk factors cannot fully explain epidemiological variations of this disease. from several years infections have been linked to ischemic vascular events and recent studies pointed to the role of helicobacter pylori (h. pylori), a spiral gram negative bacterium, that chronically infects human stomach and is involved in the pathogenesis of gastritis and peptic ulceration. systematic re ... | 2000 | 11253332 |
| expression of chlamydia pneumoniae polymorphic membrane protein family genes. | the genome of the obligate intracellular bacterium chlamydia pneumoniae cwl029 encodes a family of 21 proteins with predicted outer membrane localization. these polymorphic membrane proteins (pmps) are heterogeneous in both amino acid sequence and predicted size but are unified by the conserved amino acid motifs ggai and fxxn repeated in the n-terminal half of each protein. reverse transcriptase pcr analysis showed that all pmp genes are transcribed. to determine whether all proteins are express ... | 2001 | 11254597 |
| study of community acquired pneumonia aetiology (scapa) in adults admitted to hospital: implications for management guidelines. | since the last british study of the microbial aetiology of community acquired pneumonia (cap) about 20 years ago, new organisms have been identified (for example, chlamydia pneumoniae), new antibiotics introduced, and fresh advances made in microbiological techniques. pathogens implicated in cap in adults admitted to hospital in the uk using modern and traditional microbiological investigations are described. | 2001 | 11254821 |
| [persistence of chlamydia pneumoniae in coronary plaque tissue]. | 2000 | 11256051 | |
| independent and joint effects of antibodies to human heat-shock protein 60 and chlamydia pneumoniae infection in the development of coronary atherosclerosis. | studies have suggested that the prevalence of antibodies against heat-shock proteins (hsps), chlamydia pneumoniae (cpn), and cytomegalovirus (cmv) is associated with coronary artery disease (cad), but the independent or joint effects of human (h) hsp60 antibodies and these pathogens in patients have not been fully elucidated. | 2001 | 11257076 |
| sphingomyelin trafficking in chlamydia pneumoniae-infected cells. | chlamydia pneumoniae is a bacterial obligate intracellular parasite with a developmental cycle common to all members of the genus chlamydia. like other chlamydiae, the developmental cycle of c. pneumoniae occurs entirely within a membrane-bound intracellular vacuole, termed an inclusion, that is non-fusogenic with endosomal or lysosomal compartments. to characterize the vesicular interactions of the c. pneumoniae inclusion, we used a fluorescent analogue of ceramide, (n-[7-(4-nitrobenzo-2-oxa-1, ... | 2001 | 11260137 |
| [preparation of chlamydia pneumoniae in roller bottles with high ifus]. | 2001 | 11260884 | |
| previous exposure to chlamydia pneumoniae, helicobacter pylori and other infections in canadian patients with ischemic heart disease. | previous exposures to chlamydia pneumoniae (cp), helicobacter pylori (hp) or cytomegalovirus (cmv) have been associated with atherosclerotic heart disease. these associations were studied in canadian patients, and the exposure to five infections measured. | 2001 | 11264559 |
| chlamydia pneumoniae in vitro and in vivo: a critical evaluation of in situ detection methods. | there is a considerable discrepancy between data from the detection of chlamydia pneumoniae in atherosclerotic lesions obtained by means of immunocytochemistry and data obtained using the polymerase chain reaction. this study evaluated methods for the in situ detection and assessment of the viability of c pneumoniae bacteria. | 2000 | 11265174 |
| chlamydia pneumoniae antigens, rather than viable bacteria, persist in atherosclerotic lesions. | to evaluate the nature of the presence of chlamydia pneumoniae or of other members of the order chlamydiales in atherosclerotic lesions. | 2000 | 11265175 |
| level of plasma tissue factor pathway inhibitor is inversely correlated with intraarterial diastolic pressure in subjects who underwent coronary angiography. | there are only a few studies of the relationship between hemostatic abnormalities and intraarterial pressure, so the present study investigated the association of various newer lipid and hemostatic variables with intraarterial pressure levels. levels of total cholesterol, high-density lipoprotein cholesterol (hdl-c), low-density lipoprotein cholesterol, triglyceride, lipoprotein-(a), remnant-like particle cholesterol, cholesteryl ester transfer protein, uric acid, blood glucose, fibrinogen, free ... | 2001 | 11266189 |
| association of seropositivity for antibody to chlamydia-specific lipopolysaccharide and coronary artery disease in japanese men. | recent studies suggest an association between chlamydia pneumoniae infection and coronary artery disease (cad). to examine this relationship in japanese men, serum iga and igg antibodies to chlamydia-specific lipopolysaccharide were measured by enzyme-linked immunosorbent assay in 507 patients with cad and 200 age-matched controls. cad patients were divided into (1) 269 patients with myocardial infarction (mi) and (2) 238 patients with chronic coronary heart disease (cchd). compared with the con ... | 2001 | 11266192 |
| chlamydia pneumoniae facilitates monocyte adhesion to endothelial and smooth muscle cells. | chlamydia pneumoniae has been linked to atherosclerotic heart disease. however, there is a limited knowledge by which c. pneumoniae gain access to atheromatous lesions. the adhesion of c. pneumoniae -infected circulatory component(s) to endothelium and smooth muscle cells represents the first step in an inflammatory response. we examined the ability of viable as well as heat inactivated c. pneumoniae to infect human monocytes and subsequently the ability of infected monocytes to adhere to human ... | 2001 | 11273740 |
| distribution of chlamydia pneumoniae in the human arterial system and its relation to the local amount of atherosclerosis within the individual. | chlamydia pneumoniae has been suggested to play a role in the origin of atherosclerosis. we studied the prevalence of c pneumoniae at multiple locations in the arterial system within the same individual. studying the association between atherosclerosis and c pneumoniae within the individual excludes confounding by interindividual variability. | 2001 | 11273986 |
| c-reactive protein and chronic chlamydia pneumoniae infection--long-term predictors for cardiovascular disease and survival in patients on peritoneal dialysis. | accelerated arteriosclerosis with cardiovascular disease is the main cause of death in end-stage renal disease patients. increased, levels of c-reactive protein (crp) and evidence of chronic chlamydia pneumoniae infection have been identified as risk factors for cardiovascular disease in the general population. we tested the hypothesis that elevation of crp, indicating chronic inflammation, and positive serum antibody titres for c. pneumoniae are associated with an increased cardiovascular morta ... | 2001 | 11274279 |